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2 episodes with missing microbes
Dr. Hoffman continues his conversation with Dr. Martin Blaser, author of "Missing Microbes: How the Overuse of Antibiotics Is Fueling Our Modern Plagues."
Is the human microbiome an endangered species? Dr. Martin Blaser, author of "Missing Microbes: How the Overuse of Antibiotics Is Fueling Our Modern Plagues," has also been featured in a documentary, The Invisible Extinction, that explores the dire consequences of our depleted microbiomes. Antibiotic overuse, C-sections, lack of breast-feeding, ultra-processed food, lack of exposure to nature, and chlorinated water conspire to deplete our bodies of beneficial bacteria; these imbalances in intestinal flora have profound, far-reaching effects, not just on digestive disorders, but on immunity, metabolism, and brain function. Conditions like insulin resistance, obesity, Parkinson's Disease, depression and anxiety, and many more have been linked to microbiome deficits. What lessons do stool samples from indigenous peoples offer us? There may be a transgenerational effect of microbiome depletion. Dr. Blaser has gone so far as to advocate a Microbiome Vault to preserve our bacterial heritage. Are fecal transplants and poop pills the answer? “Vaginal seeding”? What role do high-fiber diets play? Are fermented foods beneficial? What about probiotics? Dr. Blaser describes measures we need to take now to recover our microbial diversity.
Cheryl Sew Hoy (@tiny.health) and I dive RIGHT into why mother's microbiome affects baby's gut health, why not all probiotics are helpful, how to improve baby's gut health (and yours), why any amount of breastmilk benefits baby's microbiome, and how the microbiome changes as our babies grow. And, of course, we address the question of whether or not babies need probiotics. Links to things we talk about in the episode: Tiny Health blog posts mentioned in this interview: birth plan, gentle c-sections, pediatric antibiotics, the power of dirt Missing Microbes book: amzn.to/3CWD6CI My interview with Sally Fallon about living foods and human milk: https://spoti.fi/3reSHuw Order a Tiny Health microbiome test here and use code HAPPYMAMA20 for $20 off: https://bit.ly/3XCMqVU Get 10% off Smidge Infant probiotic with code HAPPYMAMA10 here: https://bit.ly/3XwkN0x **This podcast is for educational purposes only! The opinions of myself or my guests are never meant to replace individual medical advice. Please practice informed consent with your mom intuition and your care team.** -- If you're enjoying this podcast, please subscribe and leave a review in Apple Podcasts to help other people find us! You can also find me on Instagram @happy.mama.healthy.baby for more content. Sign up for my monthly newsletter and get a free freezer meal download: https://happymamahealthybaby.ck.page Learn more about my work and schedule an in-person or virtual lactation consult at happymamahealthybaby.co Our online breastfeeding and postpartum course: https://bit.ly/nourishedbeginningscourse (15% off with code PODCAST15) Postpartum recipes and resources: https://bit.ly/nourishedmotherbundle My allergy e-cookbook: https://bit.ly/nourishedwithnuance --- Support this podcast: https://podcasters.spotify.com/pod/show/milkandmotherhood/support
Did you know that the overuse of antibiotics can disrupt our microbiome, and contribute to diseases such as asthma, obesity, diabetes, cancer, and more? Join Food Sleuth Radio host and Registered Dietitian, Melinda Hemmelgarn, for her interview with Martin Blaser, M.D., Henry Rutgers Chair of the Human Microbiome at Rutgers University, author of Missing Microbes: How the Overuse of Antibiotics Is Fueling Our Modern Plagues, and featured in the documentary film, Invisible Extinction. Blaser discusses the relationship between the human microbiome, health and disease, and the cumulative effects of exposure to antibiotics.Related website: https://www.theinvisibleextinction.com/
Dr. Maria Gloria Dominguez-Bello, Henry Rutgers Professor of Microbiome and Health and director of the Rutgers-based New Jersey Institute for Food, Nutrition and Health, and Dr. Martin Blaser, Professor of Medicine and Pathology and Laboratory Medicine and director of the Center for Advanced Biotechnology and Medicine at Rutgers (NJ) discuss the importance of preserving microbial diversity in the human microbiome. The pair, whose research was recently featured in a documentary The Invisible Extinction, are on a race to prevent the loss of ancestral microbes and save the bacteria that contribute to human health and well-being. Links for the Episode: The Invisible Extinction (documentary) Missing Microbes (book) Missing Microbes: How the Overuse of Antibiotics Is Fueling Our Modern Plagues (article) (YouTube) Missing Microbes with Dr. Martin Blaser
Welcome to episode 56 of the Mind Gut Conversation Podcast, a place to learn about groundbreaking ideas from thought leaders in the area of health, food, the science of mind body interactions and the environment. Today's guest is Dr. Martin Blaser, a pioneer and global thought leader in the area of the gut microbiome, author of over 650 original scientific articles, of the best selling book, Missing Microbes, a book targeted to general audiences, now translated into 20 languages. Together with his wife Gloria Dominguez, he stars in the new, award winning documentary The Silent Extinction. In this episode, I speak with Dr. Blaser about the following: 1. Since the publication of your best selling book Missing Microbes, what has been the most important breakthrough in microbiome science? 2. The extinction of micro- and macro-organisms are being driven by different mechanisms. Why are the two trends happening roughly on the same time course?. 3. Of the many possible disease mechanisms that could be involved in microbiome changes and increased risk of chronic diseases, which ones do you think are the most important ones? 4. What is your view of the mismatch hypothesis between a microbiome rapidly adapting to environmental/dietary changes and slowly evolving changes in the human immune system, leading to a maladaptive response of the immune system leading to systemic inflammation? In other words, are microbes better in adaptation to different lifestyles and environments than our immune system? 5. Looking into the future, do you believe that humans will dramatically change their lifestyles and their interactions with the environment to prevent catastrophic consequences on our health? A scenario you have referred to as “Antibiotic Winter”. 6. Do you see enough changes worldwide in the inappropriate and excessive use of antibiotics, C-section deliveries, diet, encroachment of wild habitats, etc. that suggest we will be able to dodge the bullet? 7. If there is one intervention that you think would have the biggest impact on our current situation, what would that be? Rather watch this episode? Check it out on YouTube: https://youtu.be/eibJT0iI5nw Follow Dr. Mayer here: https://linktr.ee/emayer
Welcome to episode 56 of the Mind Gut Conversation Podcast, a place to learn about groundbreaking ideas from thought leaders in the area of health, food, the science of mind body interactions and the environment. Today's guest is Dr. Martin Blaser, a pioneer and global thought leader in the area of the gut microbiome, author of over 650 original scientific articles, of the best selling book, Missing Microbes, a book targeted to general audiences, now translated into 20 languages. Together with his wife Gloria Dominguez, he stars in the new, award winning documentary The Silent Extinction. In this episode, I speak with Dr. Blaser about the following: 1. Since the publication of your best selling book Missing Microbes, what has been the most important breakthrough in microbiome science? 2. The extinction of micro- and macro-organisms are being driven by different mechanisms. Why are the two trends happening roughly on the same time course?. 3. Of the many possible disease mechanisms that could be involved in microbiome changes and increased risk of chronic diseases, which ones do you think are the most important ones? 4. What is your view of the mismatch hypothesis between a microbiome rapidly adapting to environmental/dietary changes and slowly evolving changes in the human immune system, leading to a maladaptive response of the immune system leading to systemic inflammation? In other words, are microbes better in adaptation to different lifestyles and environments than our immune system? 5. Looking into the future, do you believe that humans will dramatically change their lifestyles and their interactions with the environment to prevent catastrophic consequences on our health? A scenario you have referred to as “Antibiotic Winter”. 6. Do you see enough changes worldwide in the inappropriate and excessive use of antibiotics, C-section deliveries, diet, encroachment of wild habitats, etc. that suggest we will be able to dodge the bullet? 7. If there is one intervention that you think would have the biggest impact on our current situation, what would that be? Rather watch this episode? Check it out on YouTube: https://youtu.be/eibJT0iI5nw Follow Dr. Mayer here: https://linktr.ee/emayer
#256 Emily started her career as an archaeologist specialising in prehistoric human nutrition before training as a Nutritional Therapist to translate her enthusiasm for human nutrition into personalised, cutting-edge nutritional and lifestyle medicine. Emily has five years of clinical experience within the industry from running her own private practice, working within the supplement industry, and lecturing in Nutritional Therapy around the country. In this episode we cover What is meant by the term ‘missing microbes' How can missing microbes be linked to disease What can cause marked disruption of the commensal gut microbiota What happens when commensal species start to seek alternative sources of fuel What bacterial syntrophy is How can we replace/nurture missing microbes And so much more
Humans have gotten healthier and healthier over the years due to modern medicine and the power of antibiotics.. But those same antibiotics, when overused, can lead to a whole new set of ailments, most notably obesity.Martin Blaser holds the Henry Rutgers Chair of the Human Microbiome at Rutgers University, where he also serves as Professor of Medicine and Pathology & Laboratory Medicine, and as Director of the Center for Advanced Biotechnology and Medicine. Previously, he served as Chair of the Department of Medicine at New York University. A physician and microbiologist, Dr. Blaser has been studying the relationships we have with our persistently colonizing bacteria. He also wrote Missing Microbes: How the Overuse of Antibiotics Is Fueling Our Modern Plagues.He and Greg discuss the overuse of antibiotics, how the antibiotic marketplace is broken, the variability among prescribers and the role of antibiotics in livestock.Episode Quotes:The overuse of antibioticsRecently, the CDC estimated that about a third of the antibiotics used in the United States in people are unnecessary. My own estimate is that it's about 60%. That it's more than half of all the antibiotics used are unnecessary. And so now the question is when you use a lot of antibiotics, what happens?The crux of Martin's workI have two crusades. One is to do the work, to understand exactly what antibiotics are doing and how we can counteract the bad part. So we can improve our use of antibiotics. And my other crusade is to tell people about this whole issue, because most people don't understand. They don't understand that just as we're damaging our macro ecology, which we call climate change, we're damaging our micro ecology. The ecology inside us.Misinformation about bacteriaThere are plenty of bad germs. But there's been a tremendous focus on the idea that microbes are bad.”Germ” is a negative term. Kids grow up learning about germs, companies sell products fighting those bad germs. But in fact, we live in a bacterial world.Show Links:Guest Profile:Faculty Profile at Rutgers UniversityAuthor's Profile at One World PublicationMartin Blaser on LinkedInHis Work:Works on Science FridayMartin Blaser on Google ScholarMissing Microbes: How the Overuse of Antibiotics Is Fueling Our Modern Plagues
Today, I am blessed to have here with me Martha Carlin. She is a Citizen Scientist that takes a systems approach to looking at Parkinson's disease and finds the answers to PD and many chronic diseases may be in our poop. Free 7 Day Keto Challenge: http://www.ketokampchallenge.com When doctors said her husband's Parkinson's would eventually kill him, Martha Carlin said, “no it won't.” She stepped out of a successful career as a systems expert and into the new role of Citizen Scientist. After years of re-learning the sciences, pouring over research (and commissioning work at the University of Chicago), Martha is now a leading source of deep data on the human biome to unlock preventions and cures for many of our most complex health conditions. Her company, The BioCollective, links personal health history, metagenomics and microbiome analysis to uncover previously unknown links between chronic disease and diet, stress, and environment. She lives with her (thriving) husband John in Lone Tree, Colorado. In this episode, Martha speaks about her obsession with the gut microbiome and how her research helped her husband's Parkinson's diagnosis. We talk about the differences between a healthy gut and an unhealthy gut. Martha reveals the top three things you need to avoid to improve your gut health. Later, we chat all about the products that Martha has developed as a result of her research. If you're interested in improving your gut health, you can find those formulas here: https://biotiquest.com/ (Use Code: KETOK15). Free 7 Day Keto Challenge: http://www.ketokampchallenge.com 90 Day Detox Program: http://www.ketokampdetox.com Order Keto Flex: http://www.ketoflexbook.com -------------------------------------------------------- / / E P I S O D E S P ON S O R S PureForm Omega Plant Based Oils (Best Alternative to Fish Oil): http://www.purelifescience.com Use ben4 for $4.00 off. Paleo Valley beef sticks, apple cider vinegar complex, organ meat complex & more. Use the coupon code KETOKAMP15 over at https://paleovalley.com/ to receive 15% off your entire order. Text me the words "Podcast" +1 (786) 364-5002 to be added to my contacts list. [00:30] Why Martha Is So Obsessed With The Gut Microbiome and The Research She's Doing In Her Company Martha's 44-year-old otherwise healthy husband was diagnosed with Parkinson's disease. So, Martha started to teach herself about science and the human body. Food and water are the main inputs in the human body. Martha threw out all the food that wasn't organic. After ditching highly refined carbohydrates, Martha's husband started to do much better than most people with Parkinson's. Martha recommends reading Missing Microbes: How the Overuse of Antibiotics Is Fueling Our Modern Plagues: https://www.amazon.com/Missing-Microbes-Overuse-Antibiotics-Fueling/dp/1250069270/benazadi-20 [12:05] Comparing A Healthy Gut To An Unhealthy Gut People who have a relative abundance of streptococcus are in some disease category. Streptococcus loves glucose. Elevated proteobacteria is another sign of an unhealthy gut. There's a study suggesting that people who drink skim milk have a statistically significant increase in Parkinson's risk. [18:30] Glyphosate: The Main Problem That Is Disrupting Your Microbiome The number one thing disrupting the gut microbiome is glyphosate. Most people do not understand how much the use of glyphosate has increased in the last thirty years. Glyphosate changes the biochemistry of the plant. Also, it changes the biochemistry of the soil, which changes the nutritional uptake of a plant. So, you need to eat as organic as possible. Also, make your legislators aware of the glyphosate problems. [23:55] Other Things You Should Avoid To Improve Your Gut Health Avoid high fructose corn syrup. Highly processed sugars will have a significant impact on your microbiome and overall health. The highest consumption of high fructose corn syrup is usually in poor populations. Also, avoid antibiotics to improve your gut health. [28:00] All About The BioCollective and How Martha Wants To Help People Improve Their Health Martha uses the concept of collect, connect, and correct. She collects poop samples, connects the dots, and corrects the problem. Martha has worked with researchers all over the globe using their samples. Now, they formulate different products to help people. Sugar Shift is something that will help you address cravings. BiotiQuest's Sugar Shift helps your gut microbiome transform the unneeded accumulation of sugars (glucose and fructose) into mannitol. Mannitol is a sugar that isn't stored in the body, so it is naturally eliminated. Get Sugar Shift here: https://biotiquest.com/pages/sugar-shift (Use Code: “KETOK15”) [36:05] Help Your Gut By Using Ideal Immunity and Heart Centered Ideal Immunity is similar to Sugar Shift. However, this particular formula will kill foodborne pathogens. Plus, it works to restore mucosal surfaces in the gut to support your immune system. If you're traveling, Ideal Immunity is great for your gut. Get Ideal Immunity here: https://biotiquest.com/pages/ideal-immunity (Use Code: “KETOK15”) Lastly, Heart Centered is focused on cardiovascular health and lowering blood pressure. Get Martha's products here: https://biotiquest.com/ (Use Code: “KETOK15”) AND MUCH MORE! Resources from this episode: Check out Martha's Website: https://www.marthasquest.com/ The BioCollective: https://www.thebiocollective.com/ Get Martha's products here: https://biotiquest.com/ (Use Code: “KETOK15”) Follow Martha Carlin LinkedIn: https://www.linkedin.com/in/marthacarlin/ Twitter: https://twitter.com/tbcmicrobes BioCollective on LinkedIn: https://www.linkedin.com/company/the-biocollective/about/ Check out Martha speak at the White House: https://www.youtube.com/watch?v=ZXq1oOjO_Kg Watch Do Gut Microbes Predict or Cause Diseases like Parkinson's? | Martha Carlin | TEDxBoulder: https://www.youtube.com/watch?v=Ph4L_JHeB3I Join theKeto Kamp Academy: https://ketokampacademy.com/7-day-trial-a Watch Keto Kamp on YouTube: https://www.youtube.com/channel/UCUh_MOM621MvpW_HLtfkLyQ Free 7 Day Keto Challenge: http://www.ketokampchallenge.com Order Keto Flex: http://www.ketoflexbook.com -------------------------------------------------------- / / E P I S O D E S P ON S O R S PureForm Omega Plant Based Oils (Best Alternative to Fish Oil): http://www.purelifescience.com Use ben4 for $4.00 off. Paleo Valley beef sticks, apple cider vinegar complex, organ meat complex & more. Use the coupon code KETOKAMP15 over at https://paleovalley.com/ to receive 15% off your entire order. Text me the words "Podcast" +1 (786) 364-5002 to be added to my contacts list. *Some Links Are Affiliates* // F O L L O W ▸ instagram | @thebenazadi | http://bit.ly/2B1NXKW ▸ facebook | /thebenazadi | http://bit.ly/2BVvvW6 ▸ twitter | @thebenazadi http://bit.ly/2USE0so ▸clubhouse | @thebenazadi Disclaimer: This podcast is for information purposes only. Statements and views expressed on this podcast are not medical advice. This podcast including Ben Azadi disclaim responsibility from any possible adverse effects from the use of information contained herein. Opinions of guests are their own, and this podcast does not accept responsibility of statements made by guests. This podcast does not make any representations or warranties about guests qualifications or credibility. Individuals on this podcast may have a direct or non-direct interest in products or services referred to herein. If you think you have a medical problem, consult a licensed physician.
Have you ever been prescribed antibiotics? Have you ever wondered if it is really necessary? In this episode, we will explain to you, in a very interesting way, many of the concerns that currently exist about the use of antibiotics. To explain this topic, we decided to use the book "Missing Microbes" written by Martin J. Blaser and discuss the top five points discussed in the book and bring Heather's and Romi's expertise to further discuss and expand on each topic.
How Leaky Gut is Making Us Sick and Driving Chronic Inflammation | This episode is brought to you by BiOptimizers and ButcherBox.Over the last seventy-five years, an array of serious, seemingly unrelated chronic illnesses—cardiovascular disease, diabetes, metabolic syndrome, autoimmune disorders, cancer, and brain disorders—have all been steadily rising, some at astonishing rates. While we're living dramatically longer lives, many of us are suffering throughout them, creating a public health crisis of historic scale.A key principle of Functional Medicine is looking at the gut and how it impacts the entire body. All of the diseases mentioned above have a component of gut dysfunction, especially intestinal permeability, which is also known as leaky gut syndrome. When the digestive tract is inflamed and food particles are able to make their way into the bloodstream, the body goes into fight mode. This goes far beyond a stomach ache, as symptoms can occur throughout the whole body. On today's episode of The Dhru Purohit Podcast, Dhru sits down with Dr. Emeran Mayer, the author of The Gut-Immune Connection and The Mind-Gut Connection. He has studied brain-body interactions for the last forty years and is the executive director of the G. Oppenheimer Center for Neurobiology of Stress and Resilience, and the founding director of the UCLA Brain Gut Microbiome Center at the University of California at Los Angeles. His research has been supported by the National Institutes of Health for the past twenty-five years, and he is considered a pioneer and world leader in the area of brain-gut microbiome interactions and its clinical implications. In this episode, we dive into: -Industrial agriculture, antibiotics, and the implications on human health (5:35)-The connection between the overuse of antibiotics and weight gain (12:17)-How our gut bacteria evolved (17:02)-The intelligence of our gut bacteria (27:03)-How modern pesticides wreak havoc on our gut health (33:46)-How fermented foods increase microbiome diversity and lower inflammation (39:26) -The importance of diversity in our diet (51:19)-Why there is a prevalence of food sensitivity in our diet (53:12)-How to figure out what foods are negatively impacting your gut health (1:03:09)-How sleep impacts the gut microbiome (1:13:12)-The gut-immune connection (1:19:15)-Chronic disease epidemic and the susceptibility to infectious diseases like COVID-19 (1:24:40) Also mentioned in this episode:-A Fermented-Food Diet Increases Microbiome Diversity and Lowers Inflammation - https://med.stanford.edu/news/all-news/2021/07/fermented-food-diet-increases-microbiome-diversity-lowers-inflammation-Missing Microbes: How the Overuse of Antibiotics is Fueling Our Modern Plagues by Martin Blaser - https://www.amazon.com/Missing-Microbes-Overuse-Antibiotics-Fueling/dp/0805098100For more on Dr. Mayer you can follow him on Instagram @emeranmayer, on Facebook @emeranamayer, on Twitter @emeranamayer, and through his website https://emeranmayer.com/. Get his book, The Gut-Immune Connection: How Understanding the Connection Between Food and Immunity Can Help Us Regain Our Health at https://emeranmayer.com/the-gut-immune-connection-book/.For more on Dhru Purohit, be sure to follow him on Instagram @dhrupurohit, on Facebook @dhruxpurohit, on Twitter @dhrupurohit, and on YouTube @dhrupurohit. You can also text Dhru at (302) 200-5643 or click here https://my.community.com/dhrupurohit.Sign up for Dhru's Try This Newsletter - https://dhrupurohit.com/newsletter.Interested in joining The Dhru Purohit Podcast Facebook Community? Submit your request to join here: https://www.facebook.com/groups/2819627591487473/.This episode is brought to you by BiOptimizers and ButcherBox.If I had to pick one supplement that has made the biggest difference in my overall health, it would be magnesium. I personally started taking magnesium to help with my sleep, especially when I travel, and it's been super helpful. But I don't take just any old magnesium, I take BiOptimizers Magnesium Breakthrough. It contains 7 different forms of magnesium, which all have different functions in the body. I haven't found anything else like it on the market. Right now, BiOptimizers is offering my community a few special bundles and for a limited time BiOptimizers is also giving away free bottles of their bestselling products P3OM and Masszymes with select purchases, just head over to magbreakthrough.com/dhru with code DHRU10. It's really important to me to source my meat from a place I can trust. ButcherBox only partners with farmers and ranchers who believe in going above and beyond when it comes to caring for animals, the environment, and sustainability—plus they make shopping way easier by delivering it right to my doorstep. ButcherBox has a variety of different boxes, and you can choose your box and frequency. For a limited time, you can sign up today and get 2 lbs of ground beef free in your first box plus $10 off by going to butcherbox.com/dhru. See acast.com/privacy for privacy and opt-out information.
SHR # 2740:: Missing Microbes - Dr. Martin Blaser - Dr. Blaser has identified one of the prime culprits in the modern disease model - disruption of the microbiome. He has laid it squarely at the doorstep of the medical orthodoxy and their penchant to hand out antibiotics at every opportunity.
SHR # 2740:: Missing Microbes - Dr. Martin Blaser - Dr. Blaser has identified one of the prime culprits in the modern disease model - disruption of the microbiome. He has laid it squarely at the doorstep of the medical orthodoxy and their penchant to hand out antibiotics at every opportunity.
It is estimated that we, as modern people, have lost about half of the microbial species occupying our gastrointestinal (GI) tracts compared to indigenous populations who hunt and gather. Exposure to antibiotics, glyphosate residues in food, other herbicides/pesticides, synthetic sweeteners like aspartame, emulsifying agents in ice cream or salad dressings--we swim in a sea of microbiome disrupting factors. Among the consequences? Loss of a number of species crucial to health. We are just beginning to identify these lost microbes, then take steps to replenish them, a strategy that is far more powerful than just taking some commercial probiotic. For more information on Dr. Davis' programs:Books:Wheat Belly: Lose the Wheat, Lose the Weight and Find Your Path Back to Health; revised & expanded editionWheat Belly 10-Day Grain DetoxWheat Belly 30-Minute (Or Less!) CookbookUndoctored: Why Health Care Has Failed You and How You Can Become Smarter Than Your DoctorOnline media:Wheat Belly Blog: www.wheatbellyblog.comWheat Belly Facebook page: https://www.facebook.com/OfficialWheatBelly/Wheat Belly 10-Day Grain Detox private Facebook page: https://www.facebook.com/groups/527516110738721/Undoctored Inner Circle (membership website with direct interaction with Dr. Davis):InnerCircle.Undoctored.comYouTube Channel:https://www.youtube.com/channel/UCZp4ONYOXZkf92UxxNnAiKQ
My guest this week is Dr. Martin Blaser. I know Marty well due to his more recent work on antibiotics and their off-target impacts on the gut microbiome, described in his book "Missing Microbes". We discuss the origins of this work during his time tracking epidemics at the CDC, his love for the rare but fascinating Campylobacter fetus, and his seminal work on identifying a "symbiosis factor" for Helicobacter pylori.
Science Book Movement - Notion360. Revisión Online del Libro: Missing Microbes - Martin J. Blaser. Invitada: Ninon Flores. Únete a nuestra comunidad en Discord a través del siguiente enlace: https://bookmovement.co/discord See acast.com/privacy for privacy and opt-out information.
Tenacity, creativity and adaptability – these are the qualities that a CEO should embody to become a titan in their industry. Bringing in these qualities to the emerging microbiome industry, https://www.linkedin.com/in/marthacarlin/ (Martha Carlin) leads https://www.thebiocollective.com/ (The BioCollective), a unique business that invests in both consumer products and microbiological research. Driven by a passion to give people the tools to take control of their health, the BioCollective team leverages some of the most advanced expertise in microbial ecology to tap the massive potential of microbiota in promoting human health. Because of her inspiring leadership, she has won her rightful place among the 2020 Titan 100. She graces the podcast on this co-hosted episode with Bob Roark and his co-host, https://www.linkedin.com/in/jaime-nespor-zawmon-b861731/ (Jaime Zawmon), President of TITAN CEO. --- Watch the episode here:[embed]https://youtu.be/0bXNCv6gpMM[/embed] Leading With Tenacity, Creativity And Adaptability With Guest, Martha Carlin Of The BioCollective And Co-host, Jaime Zawmon Of TITAN CEOWe have quite the treat. We have a Jaime Zawmon. She is the Founder and President of https://www.titanceo.com/ (Titan CEO). We have Martha Carlin. She is the CEO and Cofounder of https://www.thebiocollective.com/ (The BioCollective). We're having a co-hosted episode. Martha, Jaime, thank you so much for being on the show. Thank you for having me. Martha, thank you and congrats on being selected to the Titan 100, a big honor. I’m very excited about it. Martha, tell us about your business and who you serve. My business is unique. It's in the field of the microbiome. For people who may not know what the microbiome is, it's the trillions of bacteria, fungi and viruses that live in and on our body. Over the last years, it's become increasingly apparent that the bacteria that live in and on our body are a critical component to our health. I recognize this after reading a book called https://www.amazon.com/Missing-Microbes-Overuse-Antibiotics-Fueling/dp/0805098100 (Missing Microbes) back in 2014, founded The BioCollective in 2015 to try to accelerate the path to discovery and helping people get healthier. By doing that, we went into an industry that most people had never heard of. It was rapidly growing and expanding. When I started the company, there were about twenty microbiome companies worldwide, and now there are thousands and thousands, but it's still pretty early days. Our company has evolved in the ways that we are serving two different customer bases. We serve the scientific research community through tools that we developed for our own work to build out a bio-bank of fecal samples and genomic data so that we could start to use artificial intelligence and machine learning to identify patterns in healthy people and diseased people. Through the tools that we developed, we received an NIH grant for $1.2 million to develop one of those quality control and research tools. The division of the BioCollective that has all these research tools is serving the scientific community, the nutrition community, pharmaceutical companies, and big food and big ag to some extent. Along the way, we developed our expertise and brought in a chief scientific officer with over 30 years of microbial ecology and developed a line and a brand of consumer products that replace lost function in the microbiome that we were able to identify through our data analytics. We have a consumer products platform called https://biotiquest.com/ (BiotiQuest) that has six products, three are currently on the market. One is for changing sugar metabolism in the body, it's called Sugar Shift. Another is for the immune system specifically protecting us and helping us ward off viral infection. That's called the Ideal Immunity. Another called Heart Centered, which is focused on cardiovascular health and the production of nitric oxide...
Nadine Artemis is author of Renegade Beauty: Reveal and Revive Your Natural Radiance and Holistic Dental Care: The Complete Guide to Healthy Teeth and Gums.She is the founder of Living Libations, an luxury line of organic wild-crafted non-GMO serums, elixirs, and essential oils for those seeking the purest of the pure botanical natural health/wellness and beauty products on the planet.Her healing creations, along with her concept of Renegade Beauty, encourages effortlessness and inspires people to rethink conventional notions of beauty and wellness.Artemis is a beauty philosopher, aromacologist, and botanical muse. Nadine believes in simplicity and a natural, rhythmic natural approach -she is a disruptor to the mainstream idea of "wellness" “beauty” and “beauty products.”A frequent commentator on health and beauty for media outlets, and her products have received rave reviews in the New York Times, Goop, New York Magazine, Vogue, InStyle, The Hollywood Reporter and many more.Described by Alanis Morissette as “a true-sense visionary”Aveda founder, Horst Rechelbacher, calls Nadine “a pure flower of creativity”In this episode we discuss- Nadine's evolution as a natural beauty researcher and creator of Living Libations. How the product and the brand have survived and thrived for so long.- Why the sun is so important for our skin as well as our well being and how we can practice healthy sun exposure for optimal health. Some of the lesser known problems with conventional sunscreen and what Living Libations products (and plants) support healthy sun exposure or protection.- Why we need to support the microbiome of our yoni/vagina and what steps we can take to do this.- All the aspects of caring for our babies to cultivate a healthy microbiome, from birth to feeding to bathing.- Natural hair care and Nadine's "no poo" method- Why our dental hygiene is not limited to our teeth and mouth and the importance of a nutrient dense diet for long term health and healthy teeth and gums.Connect with Nadinehttps://www.livinglibations.com/Instagram @livinglibationsBooks https://www.amazon.com/Nadine-Artemis/e/B0062ETSECReferencesDr Martin Blazer Missing Microbes - https://books.google.com.au/books/about/Missing_Microbes.html?id=Ehy9DwAAQBAJ&printsec=frontcover&source=kp_read_button&redir_esc=y#v=onepage&q&f=falseDr Weston A Price - https://en.wikipedia.org/wiki/Weston_PriceConnect with your Elevate hosts:Amanda NogaWebsite: - www.yogaalchemy.com.auInstagram: - https://www.instagram.com/yoga_alchemy/Join the Paths to You Membership: - https://www.yogaalchemy.info/pty-pgSarah HopkinsWebsite: - https://health-wellbeing.com.au/Instagram: - https://www.instagram.com/shopkinshealth/Facebook - facebook.com/shopkinshealthwellbeingBookings (Consultation, Mentoring, Podcast): - https://calendly.com/shopkinshealth/
Functional Naturopath Dan Sipple is back on the show with Mason today to discuss the intricaces of gut health. The pair explore the methods you can use to optimise your health and build a rocking microbiome. "You're the custodian of your microbiome. Look after it, learn how to nurture it, learn what affects it.. You want to pass that on to your kiddies. So do right by it and live long and prosper." Dan Sipple (inspired by Dr. Jason Hawrelak) Mason and Dan discuss: The origins of your personal gut bacteria and the critical life stages in which your microbiome is influenced. Gut health and pregnancy preparation. What to look out for when purchasing a probiotic supplement. Preboitics and botanical dietary variation as long term strategies for sustainable microbiome health. The lifestyle factors that damage health. The danger of restrictive diets, particularly those deficient in dietary fibre. The types of prebiotic fibre and what foods contain them (see resource section below for specifics) The benefits of short chain fatty acids (SCFA's) such as butyrate. The pros and cons of fermented foods. Soluble and insoluble fibre. How to create a gut friendly plate. Colonics and enemas. The various microbiomes within the body as a whole e.g. the scalp, the mouth, skin etc. Essential oils and the disastrous antimicrobial action they can have on the microbiome. Who is Dan Sipple? Dan is a also known as The Functional Naturopath who uses cutting-edge evidence-based medicine. Experienced in modalities such as herbal nutritional medicine, with a strong focus on environmental health and longevity, Dan has a wealth of knowledge in root-dysfunction health. Resources: Dan Website Dan Instagram Gut Health Podcast 1 Gut Health Podcast 2 Candida And Medicinal Mushrooms Podcast Vaginal Steaming Podcast Microbia Lab Testing Missing Microbes Book Prebiotic Foods: Inulin/Fructooligosaccharides (FOS) – asparagus, dandelion, onion, garlic, leek , chicory, burdock, artichoke. Galactooligosaccharides (GOS) – legumes, beans, beets, lentils, etc. Pectin - apples, bananas, potatoes, berries. Resistant Starch - green bananas, cooked cooled potatoes, plantains, sorghum, sweet potatoes. Polyphenols - the skins of dark fruits/veg best e.g. pomegranate, blackberries etc. Partially Hydrolyzed Guar Gum (PHGG). Polysaccharides/beta glucans - medicinal mushrooms, oats etc Strain Specific Probiotics - What Strain For What Condition: Leaky Gut/Strengthing The Ingregrity Of Gut Lining Saccharomyces boularrdii Lactobacillus rhamnonsus GG Lactobacillus reuteri DSM 1224 Bifidobacterium longum BB536 Establishing A Healthy Microbiome - Mums and Bubs Lactobacillus rhamnosus GG Bifidobacterium breve M-16v Bifidobacterium longum BB536 Bifidobacterium animalis BB-12 Maintaining General Gut Health - Kids and Adults L.rhamnosus LGG Lactobacillus acidophilus NCFM Bifidobacterium lactis Bi-07 Lactobacillus rhamnosus HN001 Bifidobacterium animalis ssp. lactis HN019 Rebuilding Microbiome Post Antibiotics Bifidobacterium animalis ssp. lactis BB-12 Lactobacillus rhamnosus GG Saccharomyces cerevisiae (boulardii) (SB) Allergies / Autoimmunity Lactobacillus rhamnosus GG Lactobacillus paracasei LP33 Poor Immunity / Recurrent infections Lactobacillus rhamnosus GG Lactobacillus acidophilus NCFM Bifidobacterium lactis Bi-07 Lactobacillus plantarum HEAL9 Lactobacillus paracasei 8700:2 Lactobacillus fermentum CECT5716 Lactobacillus reuteri DSM 17938 IBS Lactobacillus plantarum 299V Candida / Dysbiosis Saccharomyces cerevisiae (boulardii) (SB) Bifidobacterium lactis Bi-07 Metabolic health/Weight Loss Bifidobacterium animalis spp. lactis B420 Bifidobacterium animalis ssp. lactis HN019 Q: How Can I Support The SuperFeast Podcast? A: Tell all your friends and family and share online! We’d also love it if you could subscribe and review this podcast on iTunes. Or check us out on Stitcher :)! Plus we're on Spotify! Check Out The Transcript Here: Mason: (00:01) Hey everybody, welcoming SuperFeast podcast, favourite special friend Dan Sipple. Hey man. Dan Sipple: (00:09) Hi buddy. How you doing? Mason: (00:10) Yeah, really good. Really stoked to be having this conversation with you. It's been a little bit since we've had a podcast. You guys are cooking a baby? You know that happend since... Dan Sipple: (00:20) It's been a while. Mason: (00:21) Since our last chat. Yeah, that makes it a long while. Maybe we didn't realise you're in the early stages of baking. Dan Sipple: (00:27) Yeah baking again. It's good. It's nice and timely but with a good microbiome rehash because it's all so fresh in the mind. Mason: (00:36) Yeah. Sweet. So guys, we get a lot of people asking around gut health and Dan and I did a two part like a mega dive into gut health. We'll put the links to that in the show notes. We also did a real good conversation with Sage around candida and fungal infection, which crossed over a lot with a lot of big gut information and seemed like the missing piece was coming out of the FAQ we get around. Mason: (01:07) Which probiotic should I be taking? Should I be doing sauerkrauts and fermented foods? What's the best diet to support a microbiome, so on and so forth. And Dan and I got jamming about it a little bit when we realised we had a pretty mega podcasts that we could probably hash out. And so that's what we want to talk about. Mason: (01:23) We want to dance around the microbiome, the clinical setting of getting your gut health back into balance. What does that look like? And then what does that look like after the clinical setting, clinical probiotics perhaps. Diets and extreme diets and how they cross over into being for and against a long term strong microbiome, and when it's time to cruise over into more of a lifestyle diet, that's generally going to support many areas of the body, like our cellular metabolism and various organs. Mason: (01:58) But as well as that a microbiome and see some of the pitfalls that can come about when we over identify and go a little bit too long in a diet that's a little bit extreme. So yeah, I'm really looking forward to it because it's brought it up for me as well. Just like, all right, what's my long, because I think I'm doing really well in myself to not be overly identified with a dietary system. It's taken a lot for me over the years and just really just setting in, nestling into the home and the home cooking vibe and just making sure I've got all my little principles and while maintaining my particular healthy foods that I like, romance in the kitchen, creating a diet, which I think is going to be sustainable over decades and decades, but what are those little principles and distinctions to ensure that I'm really rocking my microbiome as I go along. But it doesn't need to be an extremism in doing one thing or another. So, yeah, any thoughts for you going into this podcast in the beginning before we dive into the first topic? Dan Sipple: (03:09) I think it'd just be a good opportunity, like you say, just to really look at it over the course of a lifestyle as we spoke about designing a lifestyle that supports a healthy microbiome from basically mum's gut health from our infancy as kids and then right through the teenage years and early adulthood and into the older years and having a longevity plan because there's definitely challenging time periods I feel like throughout the course of a human's life where for instance, like mode of birth, that's one of the biggest ones, whether the baby is a C-section or a natural birth. Dan Sipple: (03:51) And then as the immune system is developing in childhood, all that exposure to different microbes and lots of chance to pick up different bugs and whatnot. So, the chances of going on things as a child like antibiotics from say two years of age to eight years of age is another critical point. And then I feel like again, in the teenage years when people tend to throw caution to the wind and really tests their microbiome. Test their gut barrier function. The insults that get thrown at it, that's another critical time point that I guess as a clinician you see those patterns emerge quite often in people's stories. It's like you'd be doing a case history with someone. First question I usually lead with and all my patients will know this is birth mode. Dan Sipple: (04:40) How are we birthed? Was it a C-section, was it natural? What was mum's health like? Does mum have gut issues, et cetera. And the reason we ask around that is because every human's microbiome on the planet is their mum's. That's how it gets passed down. And essentially if you're vaginally birth, then you're seeded through that process. That's where your microbiome in your gut is seeded for life. So that's very, very critical. Hence why with birth modes that differ to that. So C-section for example, which is medically necessary in a lot of cases, don't get me wrong, but that can be a very initiating disturbance to long term gut issues or long term risk in terms of inflammatory conditions. Dan Sipple: (05:28) So in a nutshell, vaginal birth, lower risk of inflammatory conditions, gut conditions, skin conditions, et cetera, C-section higher risk. And then that flows over to whether you're bottle fed or breastfed. Same deal. Dan Sipple: (05:45) So yeah, going back to what I was saying, the infancy period, the teenage period. I feel like once you're in adulthood and life slows down a little bit, that's probably less... There's always going to be exceptions to the rule but there's probably less risk factors there. But it's generally speaking, anytime there's those big quantum leaps in development I reckon, you might want to be mindful. Mason: (06:09) They create little forks in the road and you can go down a particular trajectory with your health, and as you said, teenage years, it's when you are there to test yourself. You've got a lot of Jing and Kidney Essence in the system. But sometimes we don't have a conversation in our culture about just how far past the barrier we go a lot of the time. And respecting that you really... It's not a moral conversation. I don't have to feel bad and we can always do what we can to get back into balance. But it's very hard to heal something when we've gone into a real extreme. We've really tested ourselves too far and we've literally gone down a trajectory with our health from say that a critical period when we're teenagers. We've set ourselves down a path because we've tested too far. Mason: (06:54) The barrier in the gut's been, we've smashed through it, right? And therefore we are leaving ourselves susceptible to lowering the good bacteria and basically heading down an inflammatory. Just an Inferno. You just can't stop it. And it takes a lot to cool it at that point. So, all right, sweet. Mason: (07:16) So I like the fact that we've started off with that pregnancy preparation. So, although we start there and of course it's going to be the best to make sure that guts absolutely rocking in that preparation period, that everything that we're going to be talking about in this podcast is getting a little bit contributing to that conversation. What to do if you're preparing to get pregnant. And something we always say is regardless of your situation, you should be preparing to be as fertile as possible because that shows you've got fertile ground and you've got the JIng and the microbiome regardless of whether you're going to get pregnant. Mason: (07:52) So that's relevant for everyone. So that's going to come and then anything you want to say a little bit more about the birth mode and just the intricacies of a vaginal birth and how that can set you up for success bacterially? Dan Sipple: (08:04) Yeah, I think like you touched on preconception is a big one. So making sure mum's microbiome is as optimised as possible is always a great idea. And that concept is becoming really, really prominent and important. But like even 10 years ago, people just weren't necessarily having those conversations. But you talk to naturopaths that have been practising for 20 years and it's like they'll all tell you a lot of couples come in now for preconception. It's awesome. Dan Sipple: (08:36) I've got one couple down in Tilba. They're living off grid and doing so many good things to support the birth of the next baby. I remember a couple of weeks ago, I said, "How long have we got? Basically, when do you want to start trying?" And they were like, "Six months, nine months or something like that." I'm like, "Awesome. That's great. No pressure. We've got six months to do that." That's ample time versus when you see a patient who's had three or four miscarriages for example, and mum's 35 and she's under pressure. Dan Sipple: (09:10) So yeah, the longer the better. And that allows us to really, really look at the things that might be impacting that person's gut health. So for example, diet, environment, stress, medication, et cetera, et cetera. For the people that are interested, I always, as a clinician, love to see actually what bugs are in their gut and run a full microbiome assessment. Mason: (09:37) Who do you do that with these days? Dan Sipple: (09:40) I'm using microba which are an Australian based company up in Queensland and they're using technology called shotgun metagenomics, which is still DNA based assessments rather than culture. Dan Sipple: (09:53) We used to culture the stool years and years ago, but they worked out at some time point that you can only see about 30% of gut microbes using that culture. So the majority of even mainstream gastroenterologists are all in agreeance now that DNA testing is where it's at. That allows you to see, don't get me wrong, there's still bugs that come up that are unidentified, basically. We know they're there and we know what percentage of their in, but we just don't know what roles they play. But the science is catching up with them. So with this particular company, you'll get a section of the results say CAG 1456 or whatever it's like that means nothing. But if you check that in six months time, they'll probably know what that does. And I'll continually update the reports. That's really funky. It's cool. Mason: (10:38) Do you need to go through a clinician to get that test or is that available to the public as well? Dan Sipple: (10:43) Good question. I have a feeling it's available to all because I know that when you do order it and you log in to check your results, there's a general overview section, which is for the user. And then there's the practitioner section, which really dives deep into detail. So, yeah, I'm fairly certain that it's across the board for everyone. Mason: (11:03) Yeah sweet. So then getting to a vaginal birth, I feel like a lot of people are going to be, I've heard this. The mucosal lining through the whole vaginal canal is basically swabbing, seeding, all that bacterial complexity through the mouth, through the nose. Is there anything going on via, if there is a C- section, is there any recreating all of that? Is there- Dan Sipple: (11:35) Yeah. Mason: (11:35) ... enough going in through. There is? Through the vaginal canal? I mean of course it's all there? Dan Sipple: (11:40) Yeah, some still gets through. A small portion gets through. So, there is- Mason: (11:43) But I mean going and taking what's in the vaginal canal if possible. Even if there's a C-section and then running that along the orifices of the baby. Dan Sipple: (11:52) Ah, okay. Yeah, yeah, absolutely. And that's what I always recommend patients to try for. Get a good doula who can advocate. In mainstream hospital settings, it's still looked upon as a bit on the fringe and a bit odd by mainstream practitioners, but absolutely. The name of that actual, escapes me at this time point. But yeah, essentially by swabbing that area and then applying it to bub's skin and orifices and that sort of thing, you do mitigate a lot of that loss. So yeah, absolutely. I'd definitely recommend that. Mason: (12:32) This might be a bit fringe, this is just like an experimental kind of thing. What's the benefit of that when we get a little bit older as well? Dan Sipple: (12:42) Yeah, yeah. We don't know. Mason: (12:46) I guess that's what they say when all those, the sexologist blogs came out about it being really good for guys going down on girls and so on and so forth and really advocating for it it's like a really healthy treat. Dan Sipple: (13:01) Yeah. I have no doubt that it's going to increase diversity of bugs, which is always a good thing. Just want to make sure- Mason: (13:08) There's no dysbiosis in the first place. Dan Sipple: (13:09) Exactly. Mason: (13:11) Yeah, yeah. There's a good podcast there about vaginal steaming in that and we'll put that in the show notes as well. Not making any claims but always a fun little conversation there. So, moving on from birth mode, we get to breastfeeding. I feel like this is one, if you find a crone in the medical system that's saying that there's no difference between bottle feeding and breastfeeding, I feel like even a majority of the institution will disagree, which is a really nice thing to see. Institutionalised dieticians are probably still the fossils that aren't going to... So just in case you come across someone that's like, "Look, there's no difference." Good red flag. Dan Sipple: (13:57) Massive red flag. Mason: (13:58) Yeah, red flag should be like out with you. So I mean naturally, breast milk is just loaded, right? Just loaded with immunological factors and bacteria. Dan Sipple: (14:09) Oh, to the thousandth degree. You cannot match what that contains and the spectrum of what they call HMOs. Human Milk Oligosaccharides, prebiotics essentially. They are trying now of course to start trying to mimic and throw into formulas to add some prebiotic action in there. Which you know- Mason: (14:31) It's not a bad thing. Dan Sipple: (14:32) It's not a bad thing. Of course. That's right. Mason: (14:34) Because there's instances where we know it's not possible. Milk dries up, so on and so forth. You might as well make the best of an unfortunate situation. Dan Sipple: (14:45) Yeah, that's right. Mason: (14:46) Especially if there's no, is it wet nurse, especially if you can't get access to a wet nurse,, which is very difficult in this current setting. Dan Sipple: (14:55) Exactly. Exactly. And then of course there's things a mum can do dietarily to help influence the composition of the breastfeeding mum's that is to improve, flow and the composition of that breast milk such as pre and probiotics, which are beneficial particularly for babies that are young and they might have, say for example a baby that is birthed vaginally and is getting breastfed but for whatever reason picked up an infection and had to have antibiotics in the first week of life. Dan Sipple: (15:25) The good thing is that whilst you might not necessarily be able to get a capsule down that baby's throat, a mum can take a probiotic capsule or prebiotic capsule or powder or whatever and you'll get maternal transfer essentially through that milk. Mason: (15:40) We're going to go through and talk about all the different prebiotics and probiotics. Dietary and supplement based that you can be using if that's the question. Because it is always that question which probiotic do I take and which prebiotic do I take? Mason: (15:55) And I guess there's a sliding scale between all right, is there something clinically that we're actually trying to do to counter a dysbiosis or an infection? Or are we just trying to upkeep for general, the mum might be perfectly fine and just want to make sure that the breast milk is absolutely optimised. So we'll go down that wrung. And along that sliding scale and I guess in that instance it's going to fall more again into the diet, more of a general throw a wide net supplementation if they want to do it for pre and pros. So we'll just say anyone's listening in going, just tell me which one to take it if I'm in that situation. That's coming. So anything else you need to say on that? Dan Sipple: (16:35) I just wanted to add there to your point that yeah, I really want to just get the message across that probiotics are just probiotics and we'll talk about strain specificity and stuff like that. But I think it really pays to see a clinician that knows what they're doing with particular strains. And so for anyone who doesn't know what I'm talking about with the probiotic, you've got a genus a species and then a strain. Dan Sipple: (17:01) So take lactobacillus acidophilus for example. Lactobacillus is the genus, acidophilus is the species, and then what comes after that, which isn't always written on probiotic labels, actually carries all the weight. So that's your first red flag. If you're taking a probiotic or you're thinking about taking probiotics, you're looking at different products and whatnot, and then not mentioning that third component, you're just seeing the first two words essentially, that's a bit of a red flag because two strains within the same species can have completely different actions. Dan Sipple: (17:35) And a good example there is like E. coli. So Escherichia coli, Nissle 1917, the strain, great for colitis and a whole range of conditions. Escherichia coli in another strain can cause watery, bloody diarrhoea and make you really sick. So strain absolutely matters. I think there's a lot of companies out there that will probably skimp on that a little bit. And might be paying for inferior strains and then extrapolating research that's been done on good strains. And when you look at a label, unless the strain is written down there, you don't know what you're getting. Mason: (18:13) How's it going to be written? So is it going to be in a third in bracket, they're going to say what the actual strain is after the bacteria? Dan Sipple: (18:19) Exactly. Exactly. So a common one. Lactobacillus rhamnosus GG. So GG, that's the strain. That's the one with the research. If you pick up a product and it says Lactobacillus rhamnosus and nothing else after that, red flag. Yeah. Mason: (18:34) So in that instance you want to be able to talk to the... I'm sure maybe you can get a good health food store owner that's really onboard and has naturopathic skills or something like that or then if not, you can go to the actual company and start asking them what their actual strains are. Dan Sipple: (18:50) Yes, yes. Mason: (18:51) And is that the difference between you go for one that's actually super specific and you know for you particularly from all the research and just how you feel you want particular strains. Therefore you have a particular company that you don't like to buy your probiotic supplementation from because if you are not really... Look, I don't really mind, I just want lots of different strains in this. A bit more like a wild fermentation going on, where rather than just them buying a specific cheap strain of bacteria and putting that in versus them going, "Look, there's a huge variety of bacteria and strains that are going in." but I guess that's going to be then determined by what starter they are they're using in their fermentation process. Mason: (19:36) Is there validity of going, "Right. I don't want that specificity, but I want something that's a more of a wild ferment, but I want it supplemented I don't want to be having that in fermented foods as much. Can't rely on it." Dan Sipple: (19:50) Yeah, so if I'm honest, it is a little bit of a myth that taking a multi-strain probiotic is going to confer more health benefits. People seem to, I guess have a bit of a, what am I trying to say here? When someone looks at a strain that is just literally a unique strain in a probiotic, I think there's a potential for some people to think that that does very little when that couldn't be further from the truth. Sometimes literally just one strain can have extremely pivotal actions and benefits in the gut. Dan Sipple: (20:26) So more isn't always better. Having said that, you do want to make sure that if you are just doing one single strain that the number of colony forming units does meet the minimum requirement. But yeah, back to your point, I would get nervous of any company that isn't writing any of the strains down. Dan Sipple: (20:45) And then if you get in touch with and they're cagey about that information, that's another sure sign. And that happens all the time. Using a company like Metagenics, I use a few different companies and clinic here, but Metagenics are a good example of a company that do list the strain always and they've only got a handful of strains that they use probably around 10 or 12 at the most. And within that range they've got maybe eight or nine different types of probiotics. And so some contain two or three strains only, one of their multi strains is only five strains. And then they've got some just single rockstar strains with really good research. So yeah, more species, not necessarily better. Mason: (21:27) [crosstalk 00:21:28]. Dan Sipple: (21:29) Yeah, go on, sorry. Mason: (21:31) I was going to say they're all refrigerated, are they? Dan Sipple: (21:35) Yeah, yeah. You can get shelf stable probiotics and again, you just want to make sure that the strains listed in that strain has good evidence, but there's no issue around if a probiotic is shelf stable, that it's any less beneficial. Mason: (21:53) Is Metagenics... They're available to the public. Right, I'm not crazy? Dan Sipple: (21:55) No, it is a practitioner only. Mason: (21:58) It is a practitioner only? Dan Sipple: (21:59) Yeah. Mason: (22:00) All right. It's really alluding me what those... Mason: (22:03) It's really eluding me that practitioner quality that I'm seeing when I go into the health food stores. I'll have to check it out because there's a few that I've had some good results with that have been available to the public. I'll have to check it out. And I'm sure everyone listening, I'm sure has gone about and they have their fav's, but it's a good little basis to make sure that they were actually able to get the species specific when we're looking at the [crosstalk 00:22:25] Dan Sipple: (22:25) Well that's it. And I should say too that there is definitely brands, over the counter brands, non practitioner brands that are very efficacious and that do list their strains down for sure. Yeah. Mason: (22:40) Are you taking one preventatively yourself? Dan Sipple: (22:45) Look, when everything is in good shape, I tend to just focus on prebiotics and dietary diversity. So I think that needs to be the core thing that people focus on always. So generally speaking, the more diversity in your diet of plant species, so aiming for 40 to 60 different plants species a week, exposes your microbiome to various different shapes and sizes of fibre, mucilage, pectin, polyphenols, et cetera, which then grows the diversity of our microbiome. So you want a very rich microbiome in terms of species diversity. That's correlated with better health outcomes versus, like we touched on earlier, starting life with the C-section. Unfortunately, you're going to start life with a very dwindled down, poor diversity of microbes, which can be improved, of course, but yeah. So as I say, the core thing I want people to focus on is getting everything from their diet because probiotics; although, they're great. Dan Sipple: (23:45) I use them every day in clinical practice. They don't permanently colonise. Still, a lot of people I find are under that kind of idea, I think from the blogosphere basically and yeah, it's a bit of a myth that one. Some of the probiotics do hang around longer than others, two to three weeks. And in others only three or four days. They will always confer a positive action when they go through, such as modulating the immune system, compete for space or out-compete pathobionts and other pathogens along the gut wall, down regulate inflammation, et cetera. So they'll always do those sorts of things, but they don't permanently colonise whereas if you use prebiotics that is fertiliser for your own probiotics. The ones you were born with. So the better long-term strategy I find is to grow them. Mason: (24:31) You're talking about a drifter or a bit of a nomad that's still good. It has great intentions. They're coming along. They're contributing a little bit, but they're not the ones that are actually going to consistently be coming back and being the custodian of the land, setting up a little bit of a civilization in [crosstalk 00:24:48] alignment with the rest of the body that's thinking it will be continuing to pour back resources into the environment and just set up shop. Dan Sipple: (24:56) Good analogy. Mason: (24:59) I did. I try. I'm feeling it. I need that. It feels nice for me going into that imagining of that reality helps me get out of my head a little bit with it and get into my Heart and that will leave my lower dantian to feel what's going on. Mason: (25:17) I feel that storytelling is always what's necessary for me to go from a short term outcomes mentality to really making sure that when I'm 80 and 90 years old that I've had a real serious trot building this. People talk about creating a legacy in business and yet that external projection, which is noble and good, but that external projection of wanting to create a legacy out here in the world. Often, you know that it's going to be unsustainable or an element of martyrdom if that takes away from your capacity to create a legacy through your microbiome internally. Dan Sipple: (25:59) Yeah. Mason: (25:59) Yeah. I've got a little skit that I'm brewing called Bacterial Master Chef and I'd always think about you really prepare and I don't know if we've talked about it before, that legacy that microbiome that you've developed such a supple, beautiful environment. Eventually, you're going to be passing that down through your kids and through your offspring as well. Mason: (26:26) Through the sperm health is going to be directly correlated. I assume through what's going on in the microbiome and then you've got a healthy microbiome and that's really creating this solid rooting within your own household. And then just via whether its physical transfer or whether it's just transfer of your habitual internal development of that beautiful complex ecosystem that's an old growth forest. Those habits that are leading to that are going to be passed down through your own personal culture to your kids, through your friends, everyone around you and far out. That's a legacy. And then I feel like you're also preparing yourself for when you go back. Your body goes back to the earth. You're serving up that bacteria in your body in that.. Go to the Master chef kitchen and when it's all done and dusted and your bacteria reflecting with the judges of other bacteria in the world of how [crosstalk 00:27:21] that human body was prepared and it was off its back. You want to really win that contest. Dan Sipple: (27:27) Yeah. Yeah. And my mentor, Dr. Jason Hawrelak down in Tasmania says pretty much just that, we are custodians of our microbiome. You got to really think of that in that context and it's up to us to nurture it and protect it because it does get passed down. And what are we now, four or five generations or more antibiotics. So with each generation that pool of diversity is dwindling, if anyone gets a chance to read Missing Microbes. Really good book. It talks all about that. Mason: (28:00) It's like a sourdough starter. It gets passed down from generation. For me, you just feel what lights up internally. I went to a pizza joint right in Aguascalientes at the base of Machu Picchu and they had a 300 year old starter, sourdough starter for their pizzas or something like that and they had a three day ferment process for their pizzas and there's something kind of like lights up internally and you get out of that upper dantian of the head and I really got me into my Heart and the romance, something sprung up and it brings up more of a song and dance to the food and to life and that's the same internally just as who you are. You can really create some proud family tradition and something that lights you up internally by seeing that you do have something precious like a starter that gets passed down from generation to generation. Mason: (29:12) Missing Microbes. All right, that's a book we've got to get. So, I'm sure everyone knows that you've heard it to death things that are going to alter and damage microbiome, intestinal epithelial barrier and all that. Dan Sipple: (29:26) Yeah and it's a good, nice bridge to talk about how the leaky gut thing interfaces with the microbiome. So essentially, that's just the protective mucosal, thick jelly like layer that just coats the whole digestive tract. The intestinal barrier really just being our protective layer against the outside wall and then between our bloodstream. People have to think about it like that from mouth to backside, it's a hollow tube. It's still technically outside your body. So you want to make sure that the integrity and the quality of that lumen is tip-top. So, essentially the microbes throughout that entire tract do hang out in that mucosal lining and you've got about five different layers from outer to inner that comprise that and so you've got the mucosal layer and then I think by memory the last layer is the immune layer where all the immune phagocytes and interleukins and they do their dance there. Mason: (30:32) Hmm, [crosstalk 00:30:33] but that were like the macrophage, like the gut-associated lymph tissue almost. Dan Sipple: (30:37) GALT and yes, lymph tissue and whatnot. Mason: (30:40) It's why the macrophages as well are sitting there with their receptors waiting for the beta glucans from the mushies. Dan Sipple: (30:47) Exactly. You have the TLRs, the toll-like receptors waiting to get turned on, which we'll go into, but I've lost my train of thought. Mason: (30:54) Well, we were talking about that mucosal lining there being something pressured that's sitting on that skin of the gut, the epithelial barrier and so that's got a lot to do with protecting against leaky gut. Right and therefore, degenerating the physical structure that ensures that we have the potential to grow and maintain a microbiome within that mucosal lining. Dan Sipple: (31:18) That's right. Yeah. So the things that damage it we were going to lead into, so antibiotics being the biggest one. Followed by probably, nonsteroidal anti-inflammatory drugs. Proton pump inhibitors, which is a big one that is coming up hugely in the research at the mument in terms of antacids, basically or reflux and those sorts of conditions. Mason: (31:41) Are they going in because they're destroying directly the bacterial colony and therefore, the bacterial colony is what is maintaining and producing that healthy mucosal lining? Or is it destroying the actual mucus? Therefore, the bacteria don't have somewhere to live. Dan Sipple: (31:56) I think it would be both, but essentially it's down-regulating your acids and therefore, bacteria that you do ingest have an easier go. Basically, they get an easier pass at getting into that layer, so whereas your acids in the stomach, which precede the small and large intestine would normally take care of that. That's a free pass straight through because your acids are suppressed. Mason: (32:18) That's something I'd probably throw out there. This whole alkaline water thing. I know we've discussed it. You're on board with that as well. That's where I'll never get on board and a long-term alkaline water that there's maybe some validity, maybe and this is where all the data and the preaching around alkaline water comes from these short-term healing protocols, which you can see validity in extreme we're going to talk about ketogenic diets, short term ketogenic diet, right, maybe. Short term alkaline water ingesting for a healing protocol, maybe, but then when you get long-term, the antacids, the alkaline water are going to start, I assume. That's the pathway in the stomach that's going to contribute to the stripping of the microbiome. Dan Sipple: (33:00) I mean we could probably do a whole podcast just on that. Mason: (33:05) Oh, we should. All right, we'll I'll put that in there. We'll put that out there. We'll get Sage on as well and we'll talk about alkaline water. That'd be good. Dan Sipple: (33:15) So other than that we've got diet, alcohol, lack of fibre, lack of plants in the diet. Stress is a huge one. So stress and medications and alcohol probably the biggest, but yeah, essentially, I guess that's a good segway into what you and I have talked about briefly in the past on other shows is that diets that do overly emphasise protein and saturated fat and meat and that do become devoid of fibre, soluble fibre, specifically in different plant polyphenols. They happen to increase the growth of bacteria in the gut that degrade mucus, so they degrade that mucosal protective lining. Dan Sipple: (33:58) So let me just repeat that. When you're on those diets for too long. High protein, high fat without sufficient fibre to offset it. Different bugs in the gut use those as fuel. They proliferate, they start out crowding more protective types of species and they feed off mucus. So, they're going to start eating mucus in our gut and burrowing down through that layer and making that more cryptic and making that more accessible to the bloodstream and the immune system start invoking a proinflammatory response. I think people can can tell where I'm getting with that. So if that goes on for too long, then you are looking at a massive pro inflammatory response coming from the gut. Mason: (34:38) Yeah, I mean everyone can see that there's always Yin Yang and a pendulum swinging within the dietary system and so we've seen an excessive amount of industrial food over such a long time and therefore, we saw the cleansing, catabolic vegan diets, raw diets, no fat diets real void of animal proteins come into dominance. And then that went to extreme. Therefore, the universe and life will always balance itself out. The trick is not going back to the pendulum swinging too far and then we see that more of the high protein, the Atkins, ketogenesis, carnivore now, bulletproof diet being that balanced up and start really dominating what's been recommended out there in the blogosphere, so on and so forth. I think that's what you're talking about. Right? Dan Sipple: (35:32) Totally and like you said it, the pendulum can swing too far the other way. And you see that, I always say to patients, the microbes don't lie. When we look at the gut microbiome, we know what you've been eating. We can base what foods you've been eating by the look of where the bugs are at and we know what roles they play and what percentage they're representing in that person's microbiome. And so with that sort of dietary approach and I'm not against meat at all. I'm flexitarian as I like to say, but too much for too long without that fibre can lead to those dysbiotic changes and we're really starting to see saturated fat play a big role in increasing what are called pathobionts and these pathobionts produce something called lipopolysaccharide and I'll break all these terms down, but LPS, lipopolysaccharide, this is something that's on the outer shell of these gram-negative bacteria that when they get fed in sufficient amounts they produce more of and its absolute chaos for our immune system. Dan Sipple: (36:35) For whatever reason, our immune system just hates this lipopolysaccharide and launches really pro-inflammatory interleukins at them into interleukin 17 and interleukin 6 causes that pro-inflammatory response. So, to break that down, high fat, high protein, you're encouraging the growth of certain bugs in the gut that are more likely to produce these endotoxins. Dan Sipple: (36:58) The endotoxins are what damage the gut. So we used to think it was just like with leaky gut what I said before, just the medications and just the diet and just the stress and that sort of stuff, which cause the tight junctions to separate, but there's a whole new body of research which is really, really becoming super accepted right across the board about the actual bugs in the gut being responsible for all that too. Particularly, the ones that produce these endotoxins and these hydrogen sulphide gases and that's been connected to anything from gut issues themselves. Anything from Celiac to Crohn's, Ulcerative Colitis, Irritable Bowel Syndrome, all the way over to anxiety, depression, Parkinson's, Dementia because we think what can potentially happen down in that gut microbiome can also then be affected in the blood brain barrier and affect the blood brain barrier the same way because that in itself is a very similar set up with that epithelial lining which can get damaged. Mason: (37:57) Because the microbiome in itself. Dan Sipple: (37:58) Pretty much. Exactly. Mason: (38:00) Oh man. Alright, so let's just start breaking it down a little bit because I feel like this is where the boring over-identifying with diet and what macronutrients are defining who you are and defining your diet at all. It's something I know we've hit a lot. We definitely hit in the past, the boring nature of identifying on being like low fat and low protein from animal sources and then we've seen that busting of the bubble around the saturated fat is bad coming especially out of the institutionalised dietitians so we've busted that and so then it's like you see fat-fueled, hashtag fat-fueled coming up. Completely living off saturated fat because all of a sudden we've almost been given this free pass to go and eat those things and do those things that we enjoy, but yet then you start identifying with the macronutrient of my diet, saturated fat, fats. Mason: (39:11) That's my fuel and I only talk about this from personal experience because you're internally too boring to develop your own innate identity through who you are and your true nature is you have to go and look at your macronutrients in order to create an identity for yourself that you can therefore go out and create in a career and a brand or just a bit of personality so you have something to talk about and it is boring and I think that's what we're talking about here. Right and it's not going down a short route because you're interested in creating some balancing for yourself through the endocrine system. I know we've talked about ketogenesis for a short amount of time, whether it's through water fasting, which isn't a very easily accessible way to get to ketogenesis. Mason: (39:57) But you know, living off fats and ketones and bulletproofing or maybe you go down that route because you want to get your insulin receptors and your leptin receptors back to a point where they're quite healthy. You've got an intention and you go full bolt into that intention, but then what happens when you don't find a sweet spot and you over-identify. I think that's what we're talking about at all points here. Mason: (40:21) You've gone too far. You haven't realised that what goes up must come down and find a sweet spot that's sustainable for decades and so we're talking about, there's a sliding scale of the damage that you can do to yourself verse.. I know I've gone really down like that fat route for a while. It gets to a point where I can just feel sluggish and you want to talk about what we're actually going to physiologically feel. If we're rocking the fats too hard, we're creating too much bile. Therefore, we're going to be having to lead to those bacteria growing that are going to start eating more of that mucus. What are we feeling? Dan Sipple: (41:02) The things that I think of straight away from a gut perspective, oily stools so if you're wiping lots that's a pretty sure sign that your intake of fats is exceeding your gallbladder's attempt to up regulate bile to the point to where it's affecting your stool. Mason: (41:22) That's such a good little distinction then. Lots of wiping, too oily. Dan Sipple: (41:28) Totally and then the flow on from that, I guess if it is done in excess for too long, you're talking about brain fog, lethargy, just overall increased body inflammation because if we strip it back down it is going to increase our leaky gut. So then all the symptoms that you can expect to find in someone with a leaky gut, you can carry over to that. Brain fog, just general digestive disturbance, lots of gas, lots of odorous gases and always check the stool. Look at what the stool is doing. I think that's the biggest marker of whether a diet is working for you or working against you. Mason: (42:10) Okay. So it's basically about ensuring we're not consuming so much fat that we're creating an excess of bile. Basically creating a different [crosstalk 00:42:19] Dan Sipple: (42:19) The other one is nausea, which I forgot to mention too. Nausea is a classic sign of poor fat breakdown. Mason: (42:26) I can get into immediately, a lot of my fats I enjoy my tonic. Having a bit of grass fed butter is my fat and just due to all the fat solubles that I'm going to be able to get going in through there especially with such a focus on bone health and teeth health and a little bit of EMU oil is also a big favourite of mine, but I can feel if I go for that second tonic and I'm relying on a saturated fat and it's been a hard one for me to chew the fat on actually over the years is I do feel a little bit nauseous afterwards. It's very immediate for me and [crosstalk 00:43:04] I feel like... Dan Sipple: (43:04) It's saturated fats? Or do you find you would get that, say if you slay five avocados in a row as well. Mason: (43:11) Avocados. I used to have that same experience when I was a raw foodie and I was relying on the macadamia butter and the avocados to really sustain me through the day. I'd get to that feeling. I get to that point where I'd eat my salads and it'd be heaps of olive oil and heaps of avocados and say olives, but mainly that avocado factor that would kind of get in there. And I just said, I'd be feeling it. It's an oily, stagnant feeling and it's a good one to kind of get on top of because it's not like that's a bad thing to feel. It's just that it's a good thing to be able to realise so you can, so I can adjust. I mean for me it's been an interesting one because I had so many years of so much roughage and so many plants, but I was having them in more of that raw form that it left a bit of a bad taste in my mouth to an extent. Mason: (44:03) I did enjoy needing to balance out and getting a little bit more of that animal fat and animal protein. And now I really feel that they're settling in to their sweet spot and their little place and I'm acknowledging that I'm going to have to be responsible enough and go be the custodian of my microbiome to find that sweet spot, where I'm actually going to be able to create some mumentum in the development of that ecosystem. Dan Sipple: (44:28) And that's the thing, man, like that's what's so good about testing is because when you do that and you can see where these guys are at and their percentages. There's ideal percentages and don't get me wrong, we don't know what the exact perfect microbiome looks like yet. Mason: (44:41) Well it probably doesn't exist. I mean, that's like [crosstalk 00:44:45] Dan Sipple: (44:45) That's right. It's the horses for courses. That's right, but we do have a pretty good idea based on databases of healthy donors where these healthy species are meant to fall within, and you can design your diet around that. That's what's awesome about doing the gut microbiome testing is that you are going to get particular foods which we know feed up Akkermansia muciniphila and Bifidobacterium and different species in the gut that do produce these amazing substances called butyrate and other short chain fatty acids. Butyrate. We should talk about that too actually. Mason: (45:20) Well, let's get into it. I just want to kind of end on the fact that it's excessiveness and finding sweet spots, so you can kind of set and forget things in your diet and you can get on to enjoying life and celebrating life and developing your virtuous nature without taking your health down a dysbiosis route that will sneak up on you over years. And it's nice to get out of the good and bad kind of aspect of foods and just find there's always, you know, with most indigenous diets of course we've got the extreme instances with like Eskimos that are just basically all blubber and protein. Dan Sipple: (45:51) Right. Mason: (45:52) And that's a particular like fringe instance. And I think we've chatted about it before being like there's a phase of adaptation for that microbiome to find its harmony. But when you look at generally in the middle of the bell curve, which is where most of us can kind of like aim for. If we want them, by all means go and explore the fringes, just don't project it onto others until you have generational data for yourself and currently. But it's mostly like all the successful indigenous cultures, blue zone cultures, there's like that appropriate amount of saturated fat, plant in some places, most of the time it's coming, from animals that appropriate amount of protein, a lot of plant diversity, soluble, insoluble, right? And fibre. Dan Sipple: (46:39) That's exactly where I try and now more so than ever shoot my patients long-term towards that Mediterranean diet in terms of the actual research, comparing different diets. Mediterranean diet always trumps the others still. And I think exactly what you said, just because it is such a flexible approach where you're just getting a bit of everything and you're getting so much diversity and polyphenols and you're still getting your saturated fats and your proteins and whatnot. It's just that you're not relying on the same basic five foods to get them in. Mason: (47:13) Yeah, I mean that's so huge. And I also want to trump people who take that example, whether it's blue zones and say they pretty much eat nothing animal and try and use it to justify their other extreme vegan diet. I'm not getting away with that today sonny, not on my watch. I mean it is finding that sweet spot and also almost creating that legacy with how in harmony your diet can be and I'm respectful of what works and what doesn't work man. So good. It's so rad. Hey everyone, don't be so boring that you need to overly identify with your macro nutrients. If you find yourself at that point, please don't go spurting all that self-righteousness over everyone else. Chickity check yourself before you wreck yourself, because you will brand yourself in a particular way. And then it denies you the fact of getting very real. And it also denies you with being curious because what you do when you identify externally with your diet, extreme diet, even if you're over identifying with like the name of the Mediterranean diet, whatever it is, it means that when you go about and try and get testing done on yourself and you're looking for generational data, it makes you biassed and it makes you go and search for justification. Mason: (48:34) You know, misery loves company and you want to create company and basically create data that justifies your position, which is very boring. It's very boring to be around. I know that I've talked about that for myself. I've found that blandness in myself and then I've had to kind of shut up for a couple of years and really just go about that nature of that route of building something for myself, which I feel is in harmony and let the cup floweth over through curious conversations like this. Not saying I'm doing it right. Just sharing my little path and my opinion. Dan Sipple: (49:10) Hmm. And being open-minded and flexible. Mason: (49:13) Being open-minded and flexible. Hey, so did you want to go and break down any of those terms anymore? Do you feel like you've, you know, the lipopolysaccharide and that, I mean, I feel like we've dived into that, but just even going further down into diet and some of your faves, the places you're kind of like looking at to make sure that you've got like a wide variety of prebiotics getting in there? Dan Sipple: (49:39) Yeah, good point. Yeah. So I guess just to sort of preface by saying that old concept of fibre is fibre is nonsense and it comes in all different shapes and sizes. Mason: (49:52) You mean like have your bowl of all bran in the morning and your sweet? Dan Sipple: (49:55) Yeah, that's exactly what I mean. Yeah. Very dietician, very old hat, 80's, 90's mentality. There's soluble- Mason: (50:03) Dieticians are getting a flogging this podcast. Dan Sipple: (50:07) Well they will, unless they're willing to adapt to the research. You know? Mason: (50:12) I'll say there's a couple of dietitians out there I like and they're adaptive, but gosh, not many. Nope, not many. I've got a chip on my shoulder from when I had to butt heads with the dieticians that were trying to tell when my mum had her aneurysm, like nearly 10 years ago now, nine years ago. Dan Sipple: (50:32) Custard. Wasn't a custard. Mason: (50:33) Yeah, it was custard. They were basically, they were just ripping it to me about trying to go against the grain of their recommendations, giving her the golden circle orange juice. Dan Sipple: (50:43) [crosstalk 00:50:43] brain. Mason: (50:44) Yeah. Literally when it was literally custard, stock standard, golden circle, sugar infused, synthetic vitamin infused juices, which were just going to be putting in pressure through refined sugar on her system. Ra-ra. And I sat there with like the head of dietetics in the Royal North Shore. My mum's dietician and then a student, this like ratty little student right out of the institutionalised dogma, who was just trying to have a go at me because she thought I didn't know a thing or two. And then I just let her have it and ripped her into the biological healing process of the brain inflammatory processes, so on and so forth. Mason: (51:27) And I was like, I'm feel really beautifully smug about, because I was so highly charged and so traumatised and going through so much grief at that time and during those times I think for someone like that to not have tact and be projecting onto the stupid son who's just distraught and not being able to have a conversation because you're so rigid. I'm like that's where my chip on my shoulder of dieticians comes from. And yeah, as you said, I've changed my opinion and adapted so much over the years and when someone else doesn't have the capacity to do that, I'm just like "Sorry. You have ejected yourself from the conversation of relevance. So you go, I don't want to talk to you right now." So yeah, take that dietitians. Dan Sipple: (52:20) Well said. Yeah. So prebiotics and the different shapes and sizes. So look, we've got these long chain sugars and fibres. Inulin is one of them. One of my favourites. We've got fructose oligosaccharides, or FOS, we've got galactooligosaccharides, GOS, and then there's- Mason: (52:42) Galactose. What's the probiotic as well that goes by like, maybe it's just galacticose or so something like in, in that, anyway, sorry, I'm thinking about some of the names of bacteria or over the years you hear and I'm just like, Oh wow [crosstalk 00:52:59] Dan Sipple: (53:01) The names aren't forgiving. They're horrendous. Mason: (53:04) Like galactose is great. I've always, where's the dietary source of... Dan Sipple: (53:13) Galactose? Mason: (53:13) Was it galactose, am I making it? Dan Sipple: (53:15) So we've got galacto-oligo-saccharides and it's abbreviated as GOS for short. Mason: (53:21) GOS. Yeah. Dan Sipple: (53:22) And you're going to find that in legumes and beans and lentils and beets and stuff. So in the Mediterranean diet, they're getting a lot of GOS. Mason: (53:30) Where are you at with beans and the presence of lectins and that? Beans being like a peasant food, something like grain that's not necessarily natural, it's going to go against like an indigenous diet kind of style of things. I feel like there's a nice middle ground there to talk about taking advantage of the access we do have to like agriculture and realisation that some of these like prebiotic rich foods are going to be good. Maybe again it's, maybe is it just like a little bit, you know, where are you at? Dan Sipple: (53:59) I always go back to the blue zones and I just think if you know, you can't just compare the legumes consumed 500-1000 years ago to what's being produced now and say they're the same. So it's going to come back to quality at the end of the day and if they're being soaked and sprouted and cooked properly, because the reality is all that nasty crap like phytates and oxalates and lectins and a lot of that gets removed when you do those things, versus when they're picked, canned and then you heat the can of soup up for 30 seconds or whatever, different story, that's when you're going to end up with more likely chance of bloating and gastrointestinal issues. Mason: (54:38) So you can say that it's like a kitchari is not going to be a kitchari, is a kitchari, is a kitchari, is a kitchari. You look at preparation and again you've got to put time and effort into these things. If you want to go the convenience model it really is when you're going to be eligible to be in that legume, bean and lentil eating kind of category, where you might be actually doing some detrimental stuff to yourself over the time, versus I mean an almost like the preparation that you do, which I know is hard for everyone but the preparation time and the sprouting and the soaking, it kind of almost like limits the amount that you're going to be able to be having naturally and therefore you're going to have more diversity, because it takes so much effort. Right? There's like magic just in, it's the same as like a flavour of the food is, of garlic is going to limit the amount of garlic a lot of the time that you're going to be able to take, or like the flavour of Reishi is going to affect how much you're actually going to be able to dose. And so to the preparation time of foods is going to affect how much you're actually going to be able to reasonably include your diet. Therefore,. it's going to put a natural cap and help you find the sweet spot. Dan Sipple: (55:50) Totally, totally. And look, it's slow going for some people. Quite often when we do a microbiome assessment, take John Smith who's been on a paleo or a carnivore diet or whatever it is, a diet that focuses on the removal of legumes and that sort of thing and has been quite meat heavy for quite some time, 99% of the time the bugs that feed off legumes and resistant starches and whatnot and produce these beneficial compounds for us like butyrate, that heal the gut and lower inflammation, they're starved. Sometimes they're extinct totally. And that's because they've had such an over reliance on other foods and they've been on such a restricted diet that these bugs just dwindle and dwindle because they're waiting to get fed. Mason: (56:37) And what is butyrate do for the barriers again? Dan Sipple: (56:43) Sure. So when you feed your gut these types of fibres, so GOS, FOS, inulin and resistant starch, et cetera, et cetera, you're feeding beneficial microbes in the gut that when they get fed in sufficient amounts, they produce this awesome compound called short chain fatty acids. And there's different types of short chain fatty acids. One of the major ones is butyrate, which is probably the most favoured because it does have such good healing benefits for blood brain barrier function, for lowering lipopolysaccharide, healing a damaged leaky gut wall and just lowering colonic inflammation and systemic inflammation. So you want as much butyrate as you can get. So you want to feed those bugs up, you want to give them the fuel from those foods so they can produce that for you. Dan Sipple: (57:26) And yeah, sometimes it's a real hard slug to get those bugs fed up again, because those foods have been out of that person's diet for a while, reintroducing them does cause issues and it is like going, so for instance, sometimes it's like, all right I want you to go to bulk health foods or whatever it is, grab yourself a bag of black beans, go home, soak them when you're ready on a day where your gut's okay and you know, pick a Saturday or whatever, usually a day you're not at work, get literally like half a palm size and cook them over a long period of time and just start there. And I want you to do that again in three days from then and then again in three days from then and just slowly, slowly build it up. And you know when they're able to handle appreciable amounts of that. Cool. Go on to lentils, do it with lentils now and you just build them up slowly and slow and slow. And sometimes it takes like literally months, but it's good when you can show them their microbiome again in six months and say now look at that guy now. He was almost extinct in the first report, look where he is now and look how much butyrate you're producing now. Mason: (58:31) And so you're saying do that because you're going to have to go through a process of being farty and having a bit of a reaction to it or what? Dan Sipple: (58:37) You're always going to get gas. Yeah. You're always going to get gas with legumes and lentils, it's normal. I always say to folks when you're producing really odorous stinky, ridiculous amounts of gas and you know it's wrong, that is 99% of the time protein putrefaction so that is actually more from high protein and lots of saturated fats. When you're getting lots of gas from plants you'll get gas definitely, but it's usually more volume and less odour. Mason: (59:08) Well you probably also kind of talk to the fact that that gaseousness, because I've kind of opened a little bit more up to legumes and lentils and beans based on this preparation model because I've had a bit of a problem with them and with the anti-nutrients for some time. So I'm kind of trying to find my balanced approach. And again, even with those, with artichokes and you know is a big one, we call them fartichokes. Dan Sipple: (59:35) Fartichokes. Yeah. Mason: (59:35) I think it's probably also just a good gauge for where the sweet spot in your diet is long-term as well. Right? Like if it's making you noticeably, if it affects your day because you're noticeably farty, it's even just like lower the dose and don't necessarily use it as a staple of a meal. Right? Dan Sipple: (59:52) Hundred percent. And that's sometimes where I'll go in with an actual supplement, like a stripped down, like galactooligosaccharides as a fibre powder and they start on literally a pinch in their water a day, because you're doing some feeding, but it's different than say having four tablespoons of black beans or lentils and you just do it super, super slow. Yeah. Mason: (01:00:16) Man. A lot to learnings and just going through my processes on these podcasts. But yeah, I think you're right. I think there is still the presence of these legumes and even grains in traditional diets. They're just prepared and the thing is they we're just limited by what was possible to forage and procure and so you just had a reasonable amount in the diet. It's just the fact that we can get such high amounts and such easy access to these things that we just blow it out of the water and create a sometimes an unnatural reliance and to be honest, sometimes we can, I know this is speculative, but we can build upon what we've learned from our ancestors and those generationally tested diets that are actually generationally tested and just I guess try and slowly potentiate it without the ego to think that we're like necessarily improving, just honing it in based on the availability we have of things. Dan Sipple: (01:01:22) Yeah. I always think about, it's kind of like make your diet about your microbiome. Don't make it about your Instagram profile. Mason: (01:01:31) So tough. I get so many followers no, I mean like I'm vibing man. I just haven't been talking about my diet for so long. I just feel like I haven't it a right to. Appreciate the journey for sure. Dan Sipple: (01:01:42) Do you get that a lot still Mase? Like people will say, what are you eating? What have you found works for you? What are your vibing at the moment? Mason:
Visit netsuite.com/tai to download your FREE guide, “Seven Key Strategies to Grow your Profits”Go to stamps.com, and click on the microphone at the top of the homepage and type in TAI—to get a 4-week trial plus free postage and a digital scale without any long-term commitment.“We’ve grown up in under an antibiotic umbrella where we think antibiotics are going to cover and cure everything.” - Dr. Martin Blaser(click to tweet) Health is more than a diet and exercise regimen. When we take a minute to examine our health from a more global perspective, the other factors of well-being surface. Our lifestyle, our habits, our mindset—these are the things that shape a person’s vitality. And on today’s episode of The Tai Lopez Show, we are joined by Dr. Martin Blaser, the Director of The Human Microbiome Project at NYU’s School of Medicine, to discuss the dangers of antibiotic use. Dr. Blaser has 28 patents, and is the author of Missing Microbes, a book that examines how our species is devolving with the declining supply of microbes in our system.Tune in to this conversation to capture an educated perspective of the whole health ecosystem!Don’t forget! You can also listen to The Tai Lopez Show on Spotify! Click “Follow” and let me know what you think!“Our system is completely backwards. It’s a false economy. People are making a lot of money out of germaphobia.” - Dr. Martin Blaser(click to tweet)Points to Keep In MindHumans are actually a partnership between microbes and us (equal numbers of cells)Without microbes we would not be aliveThere is evidence that our supply of microbes is disappearingEvidence that this is at the root of the rising rates of autism, celiac disease, Alzheimer’s, etc. Most probiotics have not been tested in scientific studies over the long termKids who take on average more antibiotics than others turn out fatterWe only look at the benefits of antibiotics because doctors are too concerned about liabilityBabies pick up their mother’s microbes in the birth canalRising rates of cesarean sections are preventing this from happening70 years ago, agriculture experts figured out that if you feed antibiotics to animals, they gain weight fasterSome cities have an antibiotics in their drinking waterSweden uses 40% of the antibiotics we useEpidemics come from the lack of diversity in our current living situationsKids born by C-section are more prone to disease (celiac disease, juvenile diabetes, etc.)The rate of juvenile diabetes is doubling every 25 yearsA Denmark study showed that antibiotics increase risk of inflammatory bowel disease by 14% in kidsWe’ve engineered a system where the doctor-patient relationship is sterile Antibiotics change the metabolism in adults We need better diagnostics to determine viral vs. bacterial infectionsFood preservatives are antibacterials destroying our microbiomeOur good bacteria fights the bad bacteria; this is the problem with anti-bacterial productsHospitals and doctors like C-sections because they’re scheduled
Dr. Martin Blaser is the Henry Rutgers Chair of the Human Microbiome, professor of medicine and microbiology at the Rutgers Robert Wood Johnson Medical School, and author of Missing Microbes. His lab has been studying pathogenic bacteria since 1981 and the human microbiome since 2002. In the episode Dr. Blaser discusses how the overuse of antibiotics may be fueling the ills that especially bother modern society.
Martin J. Blaser, MD, is director of the Human Microbiome Program at NYU and author of the book, Missing Microbes. He sat down and spoke with us about how the microbiome plays a role in disease pathogenesis, including autoimmunity, and he also answered the question of whether all of our patients should be on probiotics! Intro :11 Background on Dr. Blaser :35 The interview 1:20 What is the microbiome? 1:25 How unique are individual microbiomes? 1:49 How does an individual’s microbiome change over time? 2:13 Microbial diversity in different populations 3:12 What’s your concern with the loss of microbiome diversity? 4:20 A bit on Blaser’s research on obesity and antibiotic use 5:21 Is the timing of antibiotic administration important, in terms of the side effects it can produce? 6:43 Worldwide antibiotic prescribing rates 7:54 The microbiome and autoimmunity 9:02 The microbiome and type 1 diabetes, IBD 10:45 Research with IL-17 12:23 Microbiota transplants 13:09 For how long is the microbiome perturbed after giving antibiotics? 13:57 Diet and microbiome findings 14:54 Probiotics, prebiotics and symbiotics 15:33 In 10 years, how will people be investigating/manipulating the microbiome? 18:18 Have we shown with research that introducing certain types of bacteria can be sustainable in the gut? 19:47 Thank you, Dr. Blaser 20:26 Summary 20:33 We’d love to hear from you! Send your comments/questions to rheuminationspodcast@healio.com. This information is brought to you by Healio and is not sponsored by, nor a part of, the American College of Rheumatology.
This episode digs into what the microbiome really is, what it does for us & how it develops. Obesity, asthma, food allergies and behavioral disorders have all been linked to problems with the gut and our bacteria. You have several POUNDS of bacteria living in your gut. And if they disappeared you would die! Your bacteria are essential to your health. There are nearly 40 TRILLION bacteria in your gut. That's about a billion bugs per millimeter. *Some links may be referral links Things I discuss in this episode that you should check out Missing Microbes by Dr. Martin Blaser Evivo Probiotic (Bifidobacterium infantis) Bio-Kult Infant Probiotic Scientific research Vaginal seeding for c-sections - https://www.nature.com/news/scientists-swab-c-section-babies-with-mothers-microbes-1.19275 FDA Says Don't Use Antibacterial Soap - https://www.fda.gov/ForConsumers/ConsumerUpdates/ucm378393.htm
In this Episode of MostlyScience, Wes is joined by Holly Bunden and Chris James as they tackle some of the science headlines of the week. We learn all about the new world record for stargazing in Australia, new breakthroughs in understanding of what causes childhood cancer (Acute lymphoblastic leukemia), and a healthy discussion about the ramifications of the Nobel committee taking the Trump nomination seriously. Subscribe for Free: http://mostlyscience.com/ Wes Wilson @WesleyWilson Holly: https://www.facebook.com/mostlyscience Chris: @SiegeTO | chrisjames.actor Citizen Science & Stargazing World Record --> http://www.abc.net.au/news/2018-05-23/stargazing-abc-world-record-attempt-by-1000s-across-australia/9787990 Missing Microbes and Cancer --> http://www.bbc.com/news/health-44199844 Donald Trump Nobel Prize Nomination --> https://www.theguardian.com/us-news/2018/may/02/donald-trump-nobel-peace-prize & https://www.telegraph.co.uk/news/2018/05/03/donald-trump-formally-nominated-nobel-peace-prize-tireless-work/ Bandwidth provided by BioLegend
We're not worthy! We're not worthy! In Episode 6, we sit down with Dr Shawn Yakimovich BSc, ND, a super REAL expert, and ask him all (some of) the tough questions, on mental health, normal poop, healthy balance, and rural dating. Schwing! Hop aboard the Merthmobile, in this incredibly informative and extremely silly mashup of your favourite neighbours and favourite fictional public access TV personalities. You'll laugh. You'll cry. You'll hurl. xo Sarah and Melody Go here to check out 'Missing Microbes' by Martin Blaser (highly recommended by Dr Shawn): www.goodreads.com/book/show/17910121-missing-microbes Find Shawn at www.kemptvillenaturopathic.com AND www.facebook.com/kemptvillenaturopathic Find Sarah at www.instagram.com/littlewrightcrew.art Find Melody's art at www.melodystarkweather.ca **Send us your rando QUESTIONS! Write us an email/send a voice note to teachmetiger [at] gmail [dot] com**
Dr. Michael Ash goes into detail explaining the correlation between gut health and chronic illnesses. He provides some very good tips to prevent and reverse illnesses and talks about one very specific fruit we should all be consuming (and is probably sitting on every countertop in America right now). He's scientifically explains everything, but in a way we can all understand. What should we know about the mucosal immune system? The vast majority of people in the world will die of inflammatory chronic illnesses. The primary mechanism for making those conditions develop is an up-regulation of the immune system. And the largest part of our immune system is the referred to mucosal immune system. In simple terms, it's all the tissues in our body that are wet: eyes, mouth, lungs, gastrointestinal tract, liver and kidneys. All these have fluids over the surface performing roles. We share all the cells in them with creatures like bacteria, viruses, worms and sometimes parasites. Some are helpful and some are problematic. The outside world reaches in to us primarily through the mucosal immune system. The better that system is to interpret the outside world, the more reliable we can be in terms of our health. The mucosal system is our body's diplomat, taking charge and care of our body. What can we do to prepare our mucosal immune system to be the best? Look at our digestive tract first. What we are putting in our body is very important in terms of how our body is going to act. First what we eat is important. Consume foods that have messages that our body recognizes. And then, what we drink. If our system does not receive foods that our body recognizes (plant based foods grown in good soil), our body's response is to produce inflammation, acting as a defense mechanism. Simply getting older we produce more inflammation. So we should consume counter regulatory defenses as we age. So what foods should we consume? Plant based foods carry messages that animal based foods do not. So the more plant based foods we consume, the better prepared our bodies will be. Vegetables that are slightly bitter in their content are more densely packed with those keys that our immune system is looking for than those that are sweeter. Crunchy veggies like brussels sprouts, broccoli, cabbage, cauliflower, parsnips, etc. which are stiff. Can be cooked or steamed, 3 to 4 times a week. These are remarkable! They are miraculous to our body to protect us against risk. If we don't consume these foods, we can survive but we cannot survive effectively. Therefore, other risks and challenges to our immune system are much more difficult to turn off and take under control. This then manifests into chronic ill health like heart disease, diabetes, arthritis, dementia, Alzheimer's, eye dysfunction, problems of reproduction and lots of gastrointestinal issues (IBS, bloating, diarrhea, cancer). Fruits that contain those good messages for our bodies, like the veggies mentioned above are apples. Eating apples can be medicinal. Cook them by cleaning them, peel, cut into cubes, drop in a pan and cook with cinnamon and raisins and water, simmer (about 6 apples), soften and loose shape but not completely disappear. Referred to as stewed apples or applesauce. You'll see a gelatinous fluid called pectin. Pectin is a raw material for bacteria inside the gastrointestinal tract. When fed with pectin they manufacture fatty acids. The organisms look for the pectin and produce a substrate, the most powerful anti-inflammatory chemical a human can produce. A study done showed that consuming 3 apples a day was the same as taking 10 mg of prednisone in the treatment of inflammatory gut problems, preventing illnesses that can ultimately create cancer. Recommend 2 to 3 apples a day cooked, if you're ill. For prevention, 1 a day. Raw is not the same as if it's cooked. Make it for dessert and feed everyone!! Get your FREE download here, Review Article: Is This a Perfect Functional Meal for Mucosal Tolerance, provided by Dr. Michael Ash to learn more about apples, the scientific rationale behind it, allergy protection, antibiotic impact, phenolic compounds, apple skins, inflammation control, the brain benefits, his applesauce recipe and more. What other things can we do to prevent inflammation in our body? Avoid additional sugars. Anything that has been refined, for example sugar, corn and other sources, the less you consume of them the lower your risk of developing long term chronic illness. Vegetables and fruits can convey benefits. So can meat, it does have a role in humans, but make it grass fed proteins. The Mediterranean style diet receives high votes because statistically it proves to be successful. Fats comes in many forms. Simplistically, fat has been vilified and is wrong. There are fats that will never find success in human health. But high quality fats will benefit the health of our brain. Our diet should contain a reasonable quantity, which is a conversation for another day altogether. PROBIOTICS Two ways to identify the consumption of probiotics. Ecological consumption is when you just pick up something at the store with a mix of strains. When a type of organism, species and strain are identified to treat a certain type of illness. Many studies have clearly shown that even if you just use a healthy strain of probiotic, you generally enjoy some improvement in overall health, by reducing inflammation. If we're over the age of 40, it is most advantageous to consume probiotics. What are the benefits or probiotics? There are 7 things that probiotics do for our health. Dr. Ash spends some time explaining what these all are, as well as the dosage recommended based on body size and age. [et_bloom_inline optin_id=optin_4] About Dr. Michael Ash: Michael Ash DO, ND, BSc, DipION was in full time clinical practice for 25 years during which time he founded and developed the largest Integrative Medicine practice in the south west of England, incorporating the philosophy of functional medicine from 1991 onward. He is no longer in full time practice having sold his practice in 1997, but devotes time to research, writing and the management of complex immune mediated illnesses through the application of natural and pharmaceutical interventions. He has specialised in the role of the wet tissues (such as the gastrointestinal and respiratory tracts) in human health for over 20 years, through the application of food and lifestyle based interventions aimed at the remediation of dysfunctional bacterial communities and associated tissues essential to a healthy mucosal immune system. The manipulation and alteration of these commensal bacteria and tissues through changes in medicine and lifestyles over the last 100 years has seen a profound move away from acute infectious diseases to more chronic complex illnesses. The changing microbial landscape including decreased diversity and loss of key stone species and their associated impact on the creation of non-resolving inflammation are increasingly causally linked to many of our burgeoning health problems. An author, researcher and presenter with skills in business development as well as clinical care, he has also been an adjunct member of the Institute for Functional Medicine’s faculty for many years, and provides a unique set of insights into the application of often complex and intersecting immune patterns for the resolution and restoration of loss of homeostasis within the framework of analytical and clinical application. Links and Resources Visit www.clinicaleducation.org to find more information about Dr. Ash's studies, and search "apples" to learn more about the benefits of apples. Dr. Ash's recommended books: Missing Microbes: How the Overuse of Antibiotics is Fueling Our Modern Plagues I Contain Multitudes: The Microbes Within Us and a Grander View of Life Dr. Ash's Favorite Music: To push through: Wake Me Up by Avicci To pump her up when feeling down: Two Sides of Lonely by The Lone Bellow To soothe when feeling tense: it changes over time but right now it's Lord Huron
This episode: Unlike most animals, caterpillars don't seem to have a resident gut microbe to help them in various ways! Thanks to Tobin Hammer for his contribution! Download Episode (14 MB, 15.3 minutes) Show notes: Microbe of the episode: Borrelia graingeri News item Journal Paper: Hammer TJ, Janzen DH, Hallwachs W, Jaffe SP, Fierer N. 2017. Caterpillars lack a resident gut microbiome. Proc Natl Acad Sci 114:9641–9646. Other interesting stories: Improving viral delivery of gene therapy across blood-brain barrier Engineered gut bacteria bind bowel cancer and kill it with vegetables Making bacteria into synthetic phage factories (paper) Preventing contamination of industrial algae cultures using predatory bacteria (paper) Finding potential new antibiotics in cockroach microbes (paper) Email questions or comments to bacteriofiles at gmail dot com. Thanks for listening! Subscribe: iTunes, RSS, Google Play. Support the show at Patreon, or check out the show at Twitter or Facebook
In which Jeff and KC welcome activist, advocate, artist, and entrepreneur Silong Chhun to the studio; Silong slowly grows to accept being an artist; he throws a comedy show; he went to Green River Community College, does radio at KGRG; Silong does the raps; drops some wisdom; Jeff has a tough week; KC has a parcel stolen; KC talks about why she wants to be a counselor; KC talks about her plans for the future; Silong arrives in America; Silong talks about why his company has the name Red Scarf Revolution; wants to build a bridge for the kids coming after; kids need to know about their history; he was raised by both parents; the king sided with the Khmer Rouge to fight the Communists; we discuss First They Killed My Father; his dad was a Lon Nul soldier in hiding; Silong's mom and dad found each other in the camp; Khmer Krom faced racism from other Cambodians; Silong didn't join a gang because he couldn't fight (and he would cry); both Silong and KC's dads picked plants in the mountains; "You gotta let me fail!": KC's autobiography; "Tacoma’s a great place to be an artist"; his dad went to Cambodia and made a movie; Silong has a great idea for a restaurant; "it's like opening up a wound thats never gonna heal"; Silong still remembers lining up his first kickflip; he's naive about how stuff's supposed to work so he just does it; Silong's trying to put together a Netflix screening here in Tacoma; Silong's doin fancy things; flying out to do a keynote speech in Chicago at the Cambodian Heritage and Genocide Museum - cambodianmuseum.org; KC wants to be a keynote speaker someday; KC loves the new Writing Process theme song (courtesy of Sean of the Movie Babies podcast); and more! Plugs: November 12th - For the Record at Parlor Live 7:30 Sunday Taylor, Rivers, and McLain November 18th - Dockyard Derby Dames bout, Pierce College Steillacoom, WA Podcasts: Audible - Just Mercy, Brian Stevenson; Missing Microbes Mental Illness Happy Hour Citizen Tacoma Movie Babies Shoutouts: Narin Vann, Jason Anspach (author of the Galaxy's Edge series), Loung Ung, Rithy Panh Check out Silong's website: redscarfrevolution.com Get involved in the show! Find us on Facebook: Everything is Awesome Podcast With Jeff and KC Join our Facebook group, Friends of Everything is Awesome! on Twitter: @EIAPodcast or by email: everythingisawesomepodcast@gmail.com
This week on How on Earth, Beth interviews Dr Martin Blaser of New York University who challenges the assumption that antibiotics are harmless drugs targeting only harmful pathogens. In his recent book, Missing Microbes, Blaser presents the evidence that antibiotics are causing the extinction of important bacteria in our microbiome. These microbes have co-evolved with us, so losing them puts us at risk of many of the rising diseases of our society: asthma, allergies, eczema and obesity. Check out his book: https://books.google.com/books/about/Missing_Microbes.html?id=RJucAwAAQBAJ Host: Beth Bennett Producer: Beth Bennett Engineer: Maeve Conran Executive Producer: Beth Bennett Listen to the show:
Dr. Michael Ash goes into detail explaining the correlation between gut health and chronic illnesses. He provides some very good tips to prevent and reverse illnesses and talks about one very specific fruit we should all be consuming (and is probably sitting on every countertop in America right now). He’s scientifically explains everything, but in a way we can all understand. What should we know about the mucosal immune system? The vast majority of people in the world will die of inflammatory chronic illnesses. The primary mechanism for making those conditions develop is an up-regulation of the immune system. And the largest part of our immune system is the referred to mucosal immune system. In simple terms, it’s all the tissues in our body that are wet: eyes, mouth, lungs, gastrointestinal tract, liver and kidneys. All these have fluids over the surface performing roles. We share all the cells in them with creatures like bacteria, viruses, worms and sometimes parasites. Some are helpful and some are problematic. The outside world reaches in to us primarily through the mucosal immune system. The better that system is to interpret the outside world, the more reliable we can be in terms of our health. The mucosal system is our body’s diplomat, taking charge and care of our body. What can we do to prepare our mucosal immune system to be the best? Look at our digestive tract first. What we are putting in our body is very important in terms of how our body is going to act. First what we eat is important. Consume foods that have messages that our body recognizes. And then, what we drink. If our system does not receive foods that our body recognizes (plant based foods grown in good soil), our body’s response is to produce inflammation, acting as a defense mechanism. Simply getting older we produce more inflammation. So we should consume counter regulatory defenses as we age. So what foods should we consume? Plant based foods carry messages that animal based foods do not. So the more plant based foods we consume, the better prepared our bodies will be. Vegetables that are slightly bitter in their content are more densely packed with those keys that our immune system is looking for than those that are sweeter. Crunchy veggies like brussels sprouts, broccoli, cabbage, cauliflower, parsnips, etc. which are stiff. Can be cooked or steamed, 3 to 4 times a week. These are remarkable! They are miraculous to our body to protect us against risk. If we don’t consume these foods, we can survive but we cannot survive effectively. Therefore, other risks and challenges to our immune system are much more difficult to turn off and take under control. This then manifests into chronic ill health like heart disease, diabetes, arthritis, dementia, Alzheimer’s, eye dysfunction, problems of reproduction and lots of gastrointestinal issues (IBS, bloating, diarrhea, cancer). Fruits that contain those good messages for our bodies, like the veggies mentioned above are apples. Eating apples can be medicinal. Cook them by cleaning them, peel, cut into cubes, drop in a pan and cook with cinnamon and raisins and water, simmer (about 6 apples), soften and loose shape but not completely disappear. Referred to as stewed apples or applesauce. You’ll see a gelatinous fluid called pectin. Pectin is a raw material for bacteria inside the gastrointestinal tract. When fed with pectin they manufacture fatty acids. The organisms look for the pectin and produce a substrate, the most powerful anti-inflammatory chemical a human can produce. A study done showed that consuming 3 apples a day was the same as taking 10 mg of prednisone in the treatment of inflammatory gut problems, preventing illnesses that can ultimately create cancer. Recommend 2 to 3 apples a day cooked, if you’re ill. For prevention, 1 a day. Raw is not the same as if it’s cooked. Make it for dessert and feed everyone!! Get your FREE download here, Review Article: Is This a Perfect Functional Meal for Mucosal Tolerance, provided by Dr. Michael Ash to learn more about apples, the scientific rationale behind it, allergy protection, antibiotic impact, phenolic compounds, apple skins, inflammation control, the brain benefits, his applesauce recipe and more. What other things can we do to prevent inflammation in our body? Avoid additional sugars. Anything that has been refined, for example sugar, corn and other sources, the less you consume of them the lower your risk of developing long term chronic illness. Vegetables and fruits can convey benefits. So can meat, it does have a role in humans, but make it grass fed proteins. The Mediterranean style diet receives high votes because statistically it proves to be successful. Fats comes in many forms. Simplistically, fat has been vilified and is wrong. There are fats that will never find success in human health. But high quality fats will benefit the health of our brain. Our diet should contain a reasonable quantity, which is a conversation for another day altogether. PROBIOTICS Two ways to identify the consumption of probiotics. Ecological consumption is when you just pick up something at the store with a mix of strains. When a type of organism, species and strain are identified to treat a certain type of illness. Many studies have clearly shown that even if you just use a healthy strain of probiotic, you generally enjoy some improvement in overall health, by reducing inflammation. If we’re over the age of 40, it is most advantageous to consume probiotics. What are the benefits or probiotics? There are 7 things that probiotics do for our health. Dr. Ash spends some time explaining what these all are, as well as the dosage recommended based on body size and age. 15 Day Fat Loss Kick Start Ebook Download your FREE copy here!! DOWNLOAD! Check your email. You will receive access for instant downloading. We respect your privacy- We will not rent, spam or sell your email. About Dr. Michael Ash: Michael Ash DO, ND, BSc, DipION was in full time clinical practice for 25 years during which time he founded and developed the largest Integrative Medicine practice in the south west of England, incorporating the philosophy of functional medicine from 1991 onward. He is no longer in full time practice having sold his practice in 1997, but devotes time to research, writing and the management of complex immune mediated illnesses through the application of natural and pharmaceutical interventions. He has specialised in the role of the wet tissues (such as the gastrointestinal and respiratory tracts) in human health for over 20 years, through the application of food and lifestyle based interventions aimed at the remediation of dysfunctional bacterial communities and associated tissues essential to a healthy mucosal immune system. The manipulation and alteration of these commensal bacteria and tissues through changes in medicine and lifestyles over the last 100 years has seen a profound move away from acute infectious diseases to more chronic complex illnesses. The changing microbial landscape including decreased diversity and loss of key stone species and their associated impact on the creation of non-resolving inflammation are increasingly causally linked to many of our burgeoning health problems. An author, researcher and presenter with skills in business development as well as clinical care, he has also been an adjunct member of the Institute for Functional Medicine’s faculty for many years, and provides a unique set of insights into the application of often complex and intersecting immune patterns for the resolution and restoration of loss of homeostasis within the framework of analytical and clinical application. Links and Resources Visit www.clinicaleducation.org to find more information about Dr. Ash’s studies, and search “apples” to learn more about the benefits of apples. Dr. Ash’s recommended books: Missing Microbes: How the Overuse of Antibiotics is Fueling Our Modern Plagues I Contain Multitudes: The Microbes Within Us and a Grander View of Life Dr. Ash’s Favorite Music: To push through: Wake Me Up by Avicci To pump her up when feeling down: Two Sides of Lonely by The Lone Bellow To soothe when feeling tense: it changes over time but right now it’s Lord Huron If you missed it, listen in on our last podcast episode: Real Stuff: Nutrient Therapies Treating Chronic Disease, #48
Topic Introduction There is a fascinating new study in Pediatrics April 2015 that raises new questions about a medical tool that has been around for almost 100 year, antibiotics. First discovered in the 1930s, antibiotics have undoubtedly saved millions of lives and have been a great tool for medical science. Until recently, doctors and scientists thought of antibiotics as targeted weapons that are able to selectively destroy germs that our bodies were fighting, invasive germs, and leave the host, your child, with a balance of healthy bacteria, so called normal flora. Recently these assumptions have started to be questioned because of an observation that farmers have known about for 60 years which is... that giving small amounts of antibiotics to growing farm animals makes them get fatter and bigger than those animals that don't get them. I think until recently that farmers assumed that these antibiotics just made the animals less sick and therefore able to grow bigger but now scientists are changing their mind about that. The new thinking, backed up by this recent data in the Journal Pediatrics, indicates that very young children who get broad spectrum antibiotics very early in life, have a greater risk of being obese by age two than children around them raised in similar circumstances. Just an association, but interesting. How Do Antibiotics Affect Children's Health? If we assume this is true why should this be? What is it about antibiotics early in life that make animals and children bigger? The current belief by many is that these antibiotics change the kind of "normal flora" the child or animal carries in their gut and changes the way the child digests food. For hard-core docsmo.com listeners, you might remember that we talked about in the book review I did of Dr. Martin Blaser's book, The Missing Microbes. It seems like the recent data is validating that thinking. Not only did the data find that antibiotics had a growth promoting effect in children, but the more potent the antibiotics and the more exposure, the bigger the growth promotion effect. I think this is powerful evidence that this is not just an association effect but also a real effect of the antibiotics. Finding the Balance So what useful information can parents get from all this. Here is what I think; If you have a child less than two years of age who is sick and needs antibiotics, have a conversation with your child's pediatrician about the potency and length of treatment that should be used. Antibiotics are here to stay when it comes to children but in the past 10 years, pediatricians are trying to pull back on their use, trying to hit the bare minimum without jeopardizing a child's health. I know those parents that oppose vaccines don't want to hear it, but vaccines are our best way of reducing exposure to antibiotics by preventing the infection from ever happening. You know that Doc Smo pearl; Prevention trumps treatment, every time! Certainly true here. As always, thanks for joining me today. I would love to hear from you and I would appreciate you taking a minute to subscribe to docsmo.com at my website or on iTunes. This is Dr. Paul Smolen, hoping I can keep you in the loop, with the latest medical scoop. Until next time. Smo Notes: 1.Antibiotic Exposure in Infancy and Risk of Being Overweight in the First 24 Months of life Pediatrics Volume 135, number 4, April 2015 The Missing Microbes by Martin Blazer, Henry Holt and Company, New York, 2014 3.Missing Microbes, by Martin Blaser MD (Book Review Pedcast) - See more at: https://www.docsmo.com/missing-microbes-by-martin-blaser-md-book-review-pedcast/#sthash.jsjUF0wY.dpuf
Why are obesity, juvenile diabetes and asthma increasing? Is it something in the environment or in our modern lifestyle? Dr. Martin Blaser thinks that it may be due to changes in our microbiome – the ecosystem of tiny microscopic creatures that live in and on us. Learn about his hypothesis that some of the greatest medical advances in the 20th century – antibiotics, C-sections and antiseptics- may be having unintended consequences. Dr. Martin Blaser has studied the role of bacteria in human disease for over 30 years. He is the director of the Human Microbiome Program at NYU. He founded the Bellevue Literary Review and has been written about in newspapers including The New Yorker, Nature, Science, The New York Times, The Washington Post, and The Wall Street Journal. His more than 100 media appearances include The Today Show, The Daily Show, Fresh Air (NPR) GMA, the BBC, The O'Reilly Factor, and CNN. He lives in New York City.
Why are obesity, juvenile diabetes and asthma increasing? Is it something in the environment or in our modern lifestyle? Dr. Martin Blaser thinks that it may be due to changes in our microbiome – the ecosystem of tiny microscopic creatures that live in and on us. Learn about his hypothesis that some of the greatest medical advances in the 20th century – antibiotics, C-sections and antiseptics- may be having unintended consequences. Dr. Martin Blaser has studied the role of bacteria in human disease for over 30 years. He is the director of the Human Microbiome Program at NYU. He founded the Bellevue Literary Review and has been written about in newspapers including The New Yorker, Nature, Science, The New York Times, The Washington Post, and The Wall Street Journal. His more than 100 media appearances include The Today Show, The Daily Show, Fresh Air (NPR) GMA, the BBC, The O'Reilly Factor, and CNN. He lives in New York City.
Why are obesity, juvenile diabetes and asthma increasing? Is it something in the environment or in our modern lifestyle? Dr. Martin Blaser thinks that it may be due to changes in our microbiome – the ecosystem of tiny microscopic creatures that live in and on us. Learn about his hypothesis that some of the greatest medical advances in the 20th century – antibiotics, C-sections and antiseptics- may be having unintended consequences. Dr. Martin Blaser has studied the role of bacteria in human disease for over 30 years. He is the director of the Human Microbiome Program at NYU. He founded the Bellevue Literary Review and has been written about in newspapers including The New Yorker, Nature, Science, The New York Times, The Washington Post, and The Wall Street Journal. His more than 100 media appearances include The Today Show, The Daily Show, Fresh Air (NPR) GMA, the BBC, The O'Reilly Factor, and CNN. He lives in New York City.
It's hard to imagine the twists and turns of evolution that gave rise to Homo Sapiens. After all, it required geologic time, and the existence of many long-gone species that were once close relatives. That may be one reason why – according to a recent poll – one-third of all Americans reject the theory of evolution. They prefer to believe that humans and other living organisms have existed in their current form since the beginning of time. But if you've ever been sick, you've been the victim of evolution on a very observable time scale. Nasty viruses and bacteria take full advantage of evolutionary forces to adapt to new hosts. And they can do it quickly. Discover how comparing the deadly 1918 flu virus with variants today may help us prevent the next pandemic. Also, while antibiotic resistance is threatening to become a major health crisis, better understanding of how bacteria evolve their defenses against our drugs may help us out. And the geneticist who sequenced the Neanderthal genome says yes, our hirsute neighbors co-mingled with humans. It's Skeptic Check … but don't take our word for it! Guests: • Svante Pääbo – Evolutionary geneticist, Max Planck Institute for Evolutionary Anthropology, author of Neanderthal Man: In Search of Lost Genomes • Ann Reid – – Molecular biologist, executive director of the National Center for Science Education, Oakland, California • Martin Blaser – Microbiologist, New York University School of Medicine, member of the National Academy of Sciences, author of Missing Microbes: How the Overuse of Antibiotics Is Fueling Our Modern Plagues • Gautam Dantas – Pathologist, immunologist, Center for Genome Sciences and Systems Biology, Washington University, Saint Louis First released March 31, 2014. Learn more about your ad choices. Visit megaphone.fm/adchoices
ENCORE It’s hard to imagine the twists and turns of evolution that gave rise to Homo Sapiens. After all, it required geologic time, and the existence of many long-gone species that were once close relatives. That may be one reason why – according to a recent poll – one-third of all Americans reject the theory of evolution. They prefer to believe that humans and other living organisms have existed in their current form since the beginning of time. But if you’ve ever been sick, you’ve been the victim of evolution on a very observable time scale. Nasty viruses and bacteria take full advantage of evolutionary forces to adapt to new hosts. And they can do it quickly. Discover how comparing the deadly 1918 flu virus with variants today may help us prevent the next pandemic. Also, while antibiotic resistance is threatening to become a major health crisis, better understanding of how bacteria evolve their defenses against our drugs may help us out. And the geneticist who sequenced the Neanderthal genome says yes, our hirsute neighbors co-mingled with humans. It’s Skeptic Check … but don’t take our word for it! Guests: • Svante Pääbo – Evolutionary geneticist, Max Planck Institute for Evolutionary Anthropology, author of Neanderthal Man: In Search of Lost Genomes • Ann Reid – – Molecular biologist, executive director of the National Center for Science Education, Oakland, California • Martin Blaser – Microbiologist, New York University School of Medicine, member of the National Academy of Sciences, author of Missing Microbes: How the Overuse of Antibiotics Is Fueling Our Modern Plagues • Gautam Dantas – Pathologist, immunologist, Center for Genome Sciences and Systems Biology, Washington University, Saint Louis First released March 31, 2014.
Dr. Martin Blaser — author of Missing Microbes — reveals how the overuse of antibiotics is fueling our modern plagues. Here’s what we talked about: 1:53 – How a small village in Venezuela proved that we really are “missing microbes” and what that actually means for you. 4:12 – What your mama (and your mama’s mama) has to do with your microbiome. 6:25 – What bacteria has to do with a virus (hint…nothing!) and why antibiotics won’t get rid of your viral infection. 8:50 – The illness spectrum, the gray area of treatment, and the “defensive medicine” being played by doctors. 12:35 – The collateral damage being done by broad spectrum antibiotics – and what the government and Big Pharma can do to stop it. 18:44 – Are antibiotics “spilling out of the farm”? How they get into our food supply and how much we are really consuming. 21:20 – The C-section connection: moms, microbes and why your baby could be getting antibiotics without you even knowing it. 29:07 – Are we supposed to have H. Pylori? The many sides of the H.Pylori story. 36:36 – Gastritis and inflammation could actually be a “normal” response and why we need to be weighing costs, not just benefits. 40:28 – Celiac and antibiotics: what the loss of our bacteria means for our immune system. 44:20 – Solutions for taking back our bacteria for a early life benefit without the late in life cost. Want the written version? Join The Transcribe Tribe for FREE transcripts at www.undergroundwellness.com! Hosted by Sean Croxton of Underground Wellness.
Equilibrium is a probiotic supplement that restores the dietary microbes lost as a by-product of widespread food sterilization. The product is a direct offshoot of research done at the NIH’s Human Microbiome Project, a $115 million dollar census of humanity’s gut flora. The data tells a clear story: as a society our digestive flora is dying off, and this lack of diversity has causal links to western stomach issues. Using a data-driven approach, General Biotics identified the groups of bacteria that are commonly missing from western microbiomes. GB then worked backwards from these data to locate missing dietary microbes that provide the needed function. In this episode, David Salamon, CEO of General Biotics and I mention: The American Gut Project Commensal bacteria protect against food allergen sensitization
Robb Wolf - The Paleo Solution Podcast - Paleo diet, nutrition, fitness, and health
Featuring guest: Dr. Martin J. Blaser, author of the book Missing Microbes.
For three billion years bacteria were the sole living inhabitants on Earth. Today humans host around 100 trillion bacterial cells, outnumbering human cells 10 to one. The three pounds of bacteria that we contain forms what is called the microbiome, … Continue reading →
Innovations in modern society have created several benefits to human health, but they may have also created changes to human development. On this episode, Dr. Martin Blaser discussed changes to the human microbiome.
On this week's show: What supplement is being linked to a longer life? Forfeiting the right to sue food companies? Were our ancestors lazy? How does modern medicine affect the microbiome? Plus a movie trailer, thoughts on the Blood Moon, a Moment of Paleo & The Hadza & Dr. Boyd Eaton After the Bell. Links for this episode:Blood Moon - Wikipedia, the free encyclopedia'Blood Moon' Attracts Stargazers, Conspiracy Theories (VIDEO)The earliest astronomers? | AlunSaltFed Up movie trailer - YouTubeFed UpWhen ‘Liking’ a Brand Online Voids the Right to Sue - NYTimes.comGeneral Mills Lawsuits Facebook Likes - Business Insider? Forced Arbitration: Good for Companies, Bad for You - YouTube? General Mills changes policy - YouTubeInterview: Martin Blaser, Author Of 'Missing Microbes' : NPRNot Everyone Needs Probiotics, Suggests Study of Hunter-Gatherer Guts | Science/AAAS | NewsGut microbiome of the Hadza hunter-gatherers : Nature Communications : Nature Publishing GroupSupplement linked to longer life in mice › News in Science (ABC Science)D-Glucosamine supplementation extends life span of nematodes and of ageing mice : Nature Communications : Nature Publishing GroupStudy links arthritis supplement glucosamine to longer life in mice | CTV NewsCNN Video - Breaking News Videos from CNN.comCNN Video - Breaking News Videos from CNN.comS. Boyd Eaton, M.D. - Long-Term Paleo: What Happens if You Follow the Ancestral Health Protocol for Thirty Years? on Vimeo
When we talk about drugs, or see the myriad array of pharmaceutical ads, we usually hear about a whole range of unique side effects. These are not just side effects, they are real effects with real medical consequences.This is true not just for the complex, highly marketed drugs, but even from our most basic antibiotics. While we’ve come think of this class of drugs as almost free from consequence, the truth is they may have bigger and more far reaching consequences than the drugs that may cause individual problems. For these drugs, the side effects may be to our whole species and to the ancient human microbiome that makes up a large part of who we are as individuals and as a species. We may be seeing these consequences every day, in the increase in childhood asthma, autism, obesity, and certain types of cancers. This discovery has been the life's work of Dr. Martin Blaser. He examines this in Missing Microbes: How the Overuse of Antibiotics Is Fueling Our Modern PlaguesMy conversation with Dr. Martin Blaser:
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