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Fall is in the air! The crunch of crisp autumn leaves, the promise of pumpkin spice migraines, and the sound of your racist Uncle Dick popping open a Natty Light. IT'S TIIIIIIIIIIIMEEE *Mariah Carey voice* for the Feminist Buzzkills annual How-The-HELL-Am-I-Gonna-Deal-With-My-Family-During-The-Holidays SPECIAL EPISODE! GUEST ROLL CALL!Joining us to arm y'all with survival tips this year is THE John Fugelsang, AKA our favorite Biblical scholar! The comedian, author, political commentator, and self-proclaimed female supremacist yaps with us about what's in the Bible and what isn't, reminds us that Jesus is a feminist, AND breaks down some of the gnarly abortion news from this week. Expect to ring in the holiday season with some Fugelsang Facts™ by the time you're done blasting this episode in your earholes, because feminist-splaining abortion and LGBTQ+ rights ALWAYS deserves a seat at the dinner table. Times are heavy, but knowledge is power, y'all. We gotchu. OPERATION SAVE ABORTION: Check out our NEW Operation Save Abortion workshop, recorded a live from Netroots Nation 2025 that'll train you in coming for anti-abobo lawmakers, spotting and fighting against fake clinics, AND gears you up on how to help someone in a banned state access abortion. You can still join the 10,000+ womb warriors fighting the patriarchy by listening to past Operation Save Abortion trainings by clicking HERE for episodes, your toolkit, marching orders, and more. HOSTS:Lizz Winstead IG: @LizzWinstead Bluesky: @LizzWinstead.bsky.socialMoji Alawode-El IG: @Mojilocks Bluesky: @Mojilocks.bsky.social SPECIAL GUEST:John Fugelsang IG/TikTok: @JohnFugelsang Bluesky: @JohnFugelsang.bsky.social GUEST LINKS:READ: John's Book "Separation of Church and Hate”John's WebsiteSUBSCRIBE: John's SubstackLISTEN: The John Fugelsang PodcastWATCH: John's LIVE Book Tour SpecialLISTEN: John Fugelsang on SiriusXM NEWS DUMP:South Carolina's Abortion Bill Is So Extreme Even Anti-Abortion Groups Have DoubtsRestrictive Anti-Abortion Bill Splits SC Senate Republicans, Fails to AdvanceBill Filed to Allow Abortion After Rape, Incest—And Require VasectomiesProminent Anti-Abortion Group Announces $80 Million Midterm Investment EPISODE LINKS:ADOPT-A-CLINIC: Affiliated Medical Services (Wisconsin)ADOPT-A-CLINIC: North East Ohio Women's Center (Ohio)Operation Save AbortionExpose Fake ClinicsBUY AAF MERCH!EMAIL your abobo questions to The Feminist BuzzkillsAAF's Abortion-Themed Rage PlaylistFOLLOW US:Listen to us ~ FBK PodcastInstagram ~ @AbortionFrontBluesky ~ @AbortionFrontTikTok ~ @AbortionFrontFacebook ~ @AbortionFrontYouTube ~ @AbortionAccessFrontTALK TO THE CHARLEY BOT FOR ABOBO OPTIONS & RESOURCES HERE!PATREON HERE! Support our work, get exclusive merch and more! DONATE TO AAF HERE!ACTIVIST CALENDAR HERE!VOLUNTEER WITH US HERE!ADOPT-A-CLINIC HERE!GET ABOBO PILLS FROM PLAN C PILLS HERE!When BS is poppin', we pop off! Hosted by Simplecast, an AdsWizz company. See pcm.adswizz.com for information about our collection and use of personal data for advertising.
Michael Louis Hassiepen is a director, actor, and the host of the Pollute Your Soul podcast. Hosted on Acast. See acast.com/privacy for more information.
Deux féminicides en quinze jours : Les auditeurs de Top FM réclament des sanctions plus sévères, de la castration à la peine capitale by TOPFM MAURITIUS
durée : 00:24:39 - Bienvenue chez vous, l'invité - Jean-Charles Vanier aborde ici les idées reçues et les bonnes pratiques pour la santé de vos compagnons. Vous aimez ce podcast ? Pour écouter tous les autres épisodes sans limite, rendez-vous sur Radio France.
We feel violated after our chat with Chainsaw Castration at UK Slam Fest.The band talk about the festival, their set, the local scene, their beef with Visions of Disfigurement, plans for the future and a lot more in this must listen interview!=====================Follow The Razor's Edge online:Web: https://therazorsedge.rocksFacebook: https://www.facebook.com/therazorsedgerocksTwitter: https://twitter.com/_therazorsedge_Instagram: https://www.instagram.com/therazorsedgerocks
Es ist ein unglaubliches Filmprojekt. Die Regisseurin Louise Weard hat letztes Jahr mit "Castration Movie Anthology I: Traps" ein Fünf-Stunden-Mumblecore-Epos über das langsame Abdriften eines Incels und das alltägliche Leben einer Trans-Sexworkerin herausgebracht, die übrigens von Louise Weard selbst gespielt wird. Vor zwei Wochen ist der zweite fünfstündige Teil erschienen: "Castration Movie Anthology II: The Best of Both Worlds". In dem versucht die Transfrau Circle aus einem Untergrund-Kult auszubrechen, der einen KI-Avatar anbetet und sich nur von Bockwurst ernährt. Auf einer Hausparty, die in einem auditiv fast unverständlichen 30-minütigen Gaspar Noé-esquen Split-Screen mündet, trifft sie auf eine neue Verbündete, die vielleicht aber gar nicht ihr Bestes will. Steht die Detransition an? Und kann der Kult besiegt werden? Christian spricht in dieser Folge mit Hylia über dieses wahnwitzige Filmprojekt, das wohl noch viele Stunden weitergeführt werden wird. Die Filme können für ein paar kanadische Dollar auf https://louiseweard.gumroad.com/l/castration-movie gekauft und runtergeladen werden.
Alicia K. Morgans, MD, MPH - Clinical Conversations in Castration-Resistant Prostate Cancer: Best Practices in Discussing Testing and Treatment With Patients
Alicia K. Morgans, MD, MPH - Clinical Conversations in Castration-Resistant Prostate Cancer: Best Practices in Discussing Testing and Treatment With Patients
Alicia K. Morgans, MD, MPH - Clinical Conversations in Castration-Resistant Prostate Cancer: Best Practices in Discussing Testing and Treatment With Patients
Alicia K. Morgans, MD, MPH - Clinical Conversations in Castration-Resistant Prostate Cancer: Best Practices in Discussing Testing and Treatment With Patients
Thoman Jefferson pitched a very odd bill that proposed chopping off peens and noses.See omnystudio.com/listener for privacy information.
Welcome to the "Week in Review," where we delve into the true stories behind this week's headlines. Your host, Tony Brueski, joins hands with a rotating roster of guests, sharing their insights and analysis on a collection of intriguing, perplexing, and often chilling stories that made the news. This is not your average news recap. With the sharp investigative lens of Tony and his guests, the show uncovers layers beneath the headlines, offering a comprehensive perspective that traditional news can often miss. From high-profile criminal trials to in-depth examinations of ongoing investigations, this podcast takes listeners on a fascinating journey through the world of true crime and current events. Each episode navigates through multiple stories, illuminating their details with factual reporting, expert commentary, and engaging conversation. Tony and his guests discuss each case's nuances, complexities, and human elements, delivering a multi-dimensional understanding to their audience. Whether you are a dedicated follower of true crime, or an everyday listener interested in the stories shaping our world, the "Week in Review" brings you the perfect balance of intrigue, information, and intelligent conversation. Expect thoughtful analysis, informed opinions, and thought-provoking discussions beyond the 24-hour news cycle. Want to comment and watch this podcast as a video? Check out our YouTube Channel. https://www.youtube.com/@hiddenkillerspod Instagram https://www.instagram.com/hiddenkillerspod/ Facebook https://www.facebook.com/hiddenkillerspod/ Tik-Tok https://www.tiktok.com/@hiddenkillerspod X Twitter https://x.com/tonybpod Listen Ad-Free On Apple Podcasts Here: https://podcasts.apple.com/us/podcast/true-crime-today-premium-plus-ad-free-advance-episode/id1705422872
Hidden Killers With Tony Brueski | True Crime News & Commentary
Welcome to the "Week in Review," where we delve into the true stories behind this week's headlines. Your host, Tony Brueski, joins hands with a rotating roster of guests, sharing their insights and analysis on a collection of intriguing, perplexing, and often chilling stories that made the news. This is not your average news recap. With the sharp investigative lens of Tony and his guests, the show uncovers layers beneath the headlines, offering a comprehensive perspective that traditional news can often miss. From high-profile criminal trials to in-depth examinations of ongoing investigations, this podcast takes listeners on a fascinating journey through the world of true crime and current events. Each episode navigates through multiple stories, illuminating their details with factual reporting, expert commentary, and engaging conversation. Tony and his guests discuss each case's nuances, complexities, and human elements, delivering a multi-dimensional understanding to their audience. Whether you are a dedicated follower of true crime, or an everyday listener interested in the stories shaping our world, the "Week in Review" brings you the perfect balance of intrigue, information, and intelligent conversation. Expect thoughtful analysis, informed opinions, and thought-provoking discussions beyond the 24-hour news cycle. Want to comment and watch this podcast as a video? Check out our YouTube Channel. https://www.youtube.com/@hiddenkillerspod Instagram https://www.instagram.com/hiddenkillerspod/ Facebook https://www.facebook.com/hiddenkillerspod/ Tik-Tok https://www.tiktok.com/@hiddenkillerspod X Twitter https://x.com/tonybpod Listen Ad-Free On Apple Podcasts Here: https://podcasts.apple.com/us/podcast/true-crime-today-premium-plus-ad-free-advance-episode/id1705422872
Welcome to the "Week in Review," where we delve into the true stories behind this week's headlines. Your host, Tony Brueski, joins hands with a rotating roster of guests, sharing their insights and analysis on a collection of intriguing, perplexing, and often chilling stories that made the news. This is not your average news recap. With the sharp investigative lens of Tony and his guests, the show uncovers layers beneath the headlines, offering a comprehensive perspective that traditional news can often miss. From high-profile criminal trials to in-depth examinations of ongoing investigations, this podcast takes listeners on a fascinating journey through the world of true crime and current events. Each episode navigates through multiple stories, illuminating their details with factual reporting, expert commentary, and engaging conversation. Tony and his guests discuss each case's nuances, complexities, and human elements, delivering a multi-dimensional understanding to their audience. Whether you are a dedicated follower of true crime, or an everyday listener interested in the stories shaping our world, the "Week in Review" brings you the perfect balance of intrigue, information, and intelligent conversation. Expect thoughtful analysis, informed opinions, and thought-provoking discussions beyond the 24-hour news cycle. Want to comment and watch this podcast as a video? Check out our YouTube Channel. https://www.youtube.com/@hiddenkillerspod Instagram https://www.instagram.com/hiddenkillerspod/ Facebook https://www.facebook.com/hiddenkillerspod/ Tik-Tok https://www.tiktok.com/@hiddenkillerspod X Twitter https://x.com/tonybpod Listen Ad-Free On Apple Podcasts Here: https://podcasts.apple.com/us/podcast/true-crime-today-premium-plus-ad-free-advance-episode/id1705422872
Welcome to the "Week in Review," where we delve into the true stories behind this week's headlines. Your host, Tony Brueski, joins hands with a rotating roster of guests, sharing their insights and analysis on a collection of intriguing, perplexing, and often chilling stories that made the news. This is not your average news recap. With the sharp investigative lens of Tony and his guests, the show uncovers layers beneath the headlines, offering a comprehensive perspective that traditional news can often miss. From high-profile criminal trials to in-depth examinations of ongoing investigations, this podcast takes listeners on a fascinating journey through the world of true crime and current events. Each episode navigates through multiple stories, illuminating their details with factual reporting, expert commentary, and engaging conversation. Tony and his guests discuss each case's nuances, complexities, and human elements, delivering a multi-dimensional understanding to their audience. Whether you are a dedicated follower of true crime, or an everyday listener interested in the stories shaping our world, the "Week in Review" brings you the perfect balance of intrigue, information, and intelligent conversation. Expect thoughtful analysis, informed opinions, and thought-provoking discussions beyond the 24-hour news cycle. Want to comment and watch this podcast as a video? Check out our YouTube Channel. https://www.youtube.com/@hiddenkillerspod Instagram https://www.instagram.com/hiddenkillerspod/ Facebook https://www.facebook.com/hiddenkillerspod/ Tik-Tok https://www.tiktok.com/@hiddenkillerspod X Twitter https://x.com/tonybpod Listen Ad-Free On Apple Podcasts Here: https://podcasts.apple.com/us/podcast/true-crime-today-premium-plus-ad-free-advance-episode/id1705422872
Jake Haro Case: Castration, Competency Tests & Child Safety: Should Society Go Further? What does it mean to have the capacity to parent? In this gripping segment, Tony Brueski and psychotherapist Shavaun Scott wrestle with the uncomfortable truth: not everyone can or should be raising children. The Haro case sparks a brutally honest conversation about America's obsession with “positive thinking” — the idea that anyone can change if they just try. But when it comes to protecting kids, blind faith is a death sentence. Jake Haro attended parenting classes, checked the required boxes, and was rated “low risk.” Weeks later, his baby was dead. Tony and Shavaun explore the difference between positive thinking and magical thinking, questioning why courts continue to assume abusers can be rehabilitated with a weekend class or compliance checklist. The discussion veers into dystopian territory — competency tests for reproduction, mandatory castration for repeat abusers — but the underlying point is serious: we are giving violent, unfit parents chance after chance, while children pay the price. This segment is provocative, raw, and absolutely necessary. It challenges viewers to confront uncomfortable questions about parental rights, societal responsibility, and whether protecting children should come before protecting the freedom of abusers. Hashtags: #ChildAbuse #HiddenKillers #EmmanuelHaro #Parenting #SystemFailure #TrueCrime #TonyBrueski #ShavaunScott #MagicalThinking #ChildSafety Want to comment and watch this podcast as a video? Check out our YouTube Channel. https://www.youtube.com/@hiddenkillerspod Instagram https://www.instagram.com/hiddenkillerspod/ Facebook https://www.facebook.com/hiddenkillerspod/ Tik-Tok https://www.tiktok.com/@hiddenkillerspod X Twitter https://x.com/tonybpod Listen Ad-Free On Apple Podcasts Here: https://podcasts.apple.com/us/podcast/true-crime-today-premium-plus-ad-free-advance-episode/id1705422872
Hidden Killers With Tony Brueski | True Crime News & Commentary
Jake Haro Case: Castration, Competency Tests & Child Safety: Should Society Go Further? What does it mean to have the capacity to parent? In this gripping segment, Tony Brueski and psychotherapist Shavaun Scott wrestle with the uncomfortable truth: not everyone can or should be raising children. The Haro case sparks a brutally honest conversation about America's obsession with “positive thinking” — the idea that anyone can change if they just try. But when it comes to protecting kids, blind faith is a death sentence. Jake Haro attended parenting classes, checked the required boxes, and was rated “low risk.” Weeks later, his baby was dead. Tony and Shavaun explore the difference between positive thinking and magical thinking, questioning why courts continue to assume abusers can be rehabilitated with a weekend class or compliance checklist. The discussion veers into dystopian territory — competency tests for reproduction, mandatory castration for repeat abusers — but the underlying point is serious: we are giving violent, unfit parents chance after chance, while children pay the price. This segment is provocative, raw, and absolutely necessary. It challenges viewers to confront uncomfortable questions about parental rights, societal responsibility, and whether protecting children should come before protecting the freedom of abusers. Hashtags: #ChildAbuse #HiddenKillers #EmmanuelHaro #Parenting #SystemFailure #TrueCrime #TonyBrueski #ShavaunScott #MagicalThinking #ChildSafety Want to comment and watch this podcast as a video? Check out our YouTube Channel. https://www.youtube.com/@hiddenkillerspod Instagram https://www.instagram.com/hiddenkillerspod/ Facebook https://www.facebook.com/hiddenkillerspod/ Tik-Tok https://www.tiktok.com/@hiddenkillerspod X Twitter https://x.com/tonybpod Listen Ad-Free On Apple Podcasts Here: https://podcasts.apple.com/us/podcast/true-crime-today-premium-plus-ad-free-advance-episode/id1705422872
Jake Haro Case: Castration, Competency Tests & Child Safety: Should Society Go Further? What does it mean to have the capacity to parent? In this gripping segment, Tony Brueski and psychotherapist Shavaun Scott wrestle with the uncomfortable truth: not everyone can or should be raising children. The Haro case sparks a brutally honest conversation about America's obsession with “positive thinking” — the idea that anyone can change if they just try. But when it comes to protecting kids, blind faith is a death sentence. Jake Haro attended parenting classes, checked the required boxes, and was rated “low risk.” Weeks later, his baby was dead. Tony and Shavaun explore the difference between positive thinking and magical thinking, questioning why courts continue to assume abusers can be rehabilitated with a weekend class or compliance checklist. The discussion veers into dystopian territory — competency tests for reproduction, mandatory castration for repeat abusers — but the underlying point is serious: we are giving violent, unfit parents chance after chance, while children pay the price. This segment is provocative, raw, and absolutely necessary. It challenges viewers to confront uncomfortable questions about parental rights, societal responsibility, and whether protecting children should come before protecting the freedom of abusers. Hashtags: #ChildAbuse #HiddenKillers #EmmanuelHaro #Parenting #SystemFailure #TrueCrime #TonyBrueski #ShavaunScott #MagicalThinking #ChildSafety Want to comment and watch this podcast as a video? Check out our YouTube Channel. https://www.youtube.com/@hiddenkillerspod Instagram https://www.instagram.com/hiddenkillerspod/ Facebook https://www.facebook.com/hiddenkillerspod/ Tik-Tok https://www.tiktok.com/@hiddenkillerspod X Twitter https://x.com/tonybpod Listen Ad-Free On Apple Podcasts Here: https://podcasts.apple.com/us/podcast/true-crime-today-premium-plus-ad-free-advance-episode/id1705422872
Jake Haro Case: Castration, Competency Tests & Child Safety: Should Society Go Further? What does it mean to have the capacity to parent? In this gripping segment, Tony Brueski and psychotherapist Shavaun Scott wrestle with the uncomfortable truth: not everyone can or should be raising children. The Haro case sparks a brutally honest conversation about America's obsession with “positive thinking” — the idea that anyone can change if they just try. But when it comes to protecting kids, blind faith is a death sentence. Jake Haro attended parenting classes, checked the required boxes, and was rated “low risk.” Weeks later, his baby was dead. Tony and Shavaun explore the difference between positive thinking and magical thinking, questioning why courts continue to assume abusers can be rehabilitated with a weekend class or compliance checklist. The discussion veers into dystopian territory — competency tests for reproduction, mandatory castration for repeat abusers — but the underlying point is serious: we are giving violent, unfit parents chance after chance, while children pay the price. This segment is provocative, raw, and absolutely necessary. It challenges viewers to confront uncomfortable questions about parental rights, societal responsibility, and whether protecting children should come before protecting the freedom of abusers. Hashtags: #ChildAbuse #HiddenKillers #EmmanuelHaro #Parenting #SystemFailure #TrueCrime #TonyBrueski #ShavaunScott #MagicalThinking #ChildSafety Want to comment and watch this podcast as a video? Check out our YouTube Channel. https://www.youtube.com/@hiddenkillerspod Instagram https://www.instagram.com/hiddenkillerspod/ Facebook https://www.facebook.com/hiddenkillerspod/ Tik-Tok https://www.tiktok.com/@hiddenkillerspod X Twitter https://x.com/tonybpod Listen Ad-Free On Apple Podcasts Here: https://podcasts.apple.com/us/podcast/true-crime-today-premium-plus-ad-free-advance-episode/id1705422872
Welcome to BCI Cattle Chat! In this week's episode of Cattle Chat, we start by answering a listener question pertaining to newborn calves with flies. Next, the crew go over BCI's other podcast Bovine Science. Finally Brad brings a research paper which analyzes the benefits of castration at an early age. Thanks for listening and… Continue reading Newborn Fly Control, Bovine Science, Castration Research
In this episode, Rebecca McOnie, DVM, ACVS, joined us to discuss equine castrations, including her preferred surgical techniques, anesthesia recommendations, safety considerations, and more.This episode of Disease Du Jour is brought to you by Equithrive.GUESTS AND LINKS - EPISODE 165Host: Carly Sisson (Digital Content Manager) of EquiManagement | Email Carly (CSisson@equinenetwork.com)Guest: Dr. Jane ManfrediPodcast Website: Disease Du JourThis episode of Disease Du Jour podcast is brought to you by Equithrive.Connect with the Host: Carly Sisson (Digital Content Manager) of EquiManagement | Email Carly (CSisson@equinenetwork.com)
In this episode, Rebecca McOnie, DVM, ACVS, joined us to discuss equine castrations, including her preferred surgical techniques, anesthesia recommendations, safety considerations, and more.This episode of Disease Du Jour is brought to you by Equithrive.GUESTS AND LINKS - EPISODE 165Host: Carly Sisson (Digital Content Manager) of EquiManagement | Email Carly (CSisson@equinenetwork.com)Guest: Dr. Jane ManfrediPodcast Website: Disease Du JourThis episode of Disease Du Jour podcast is brought to you by Equithrive.Connect with the Host: Carly Sisson (Digital Content Manager) of EquiManagement | Email Carly (CSisson@equinenetwork.com)
Congrats to Taylor Swift! Get to know us if you are new around here, hot girl humor, and please support the show by buying Lindsay a Bernese Mountain Dog puppy.Bits & Clips00:00 Our origin story07:26 Personal development is dead09:03 Gluten detective12:37 Sweaters over our shoulders15:55 Sydney Sweeney & hot girl humor18:05 Confidence boost20:14 Trying to get Chelsea a date24:26 Shrek Dating25:46 Castration is on the come back28:14 Fentanyl fold30:22 Stick to coke33:10 It must be hard to be North West35:45 Lindsay's loose taint updateSend us a textTwo Awesome PeopleNew Episodes Every Monday and Thursday!Listen on: Apple Podcasts SpotifySupport the showShare this episode with your besties! Connect with Honestly Smartlesshonestlysmartless.comIG: @honestlysmartlessTikTok: @honestlysmartlessChelsea's IG: @chelsea_turanoLindsay's IG: @dr.lindsayregehrYouTube: Honestly Smartless Send us a text Support the show and will give you a shout out
Facing a rising PSA can be unsettling. But is early castration really the answer? In this episode, Dr. Stephen Petteruti walks through the harsh truth about androgen deprivation therapy (ADT), commonly known as medical castration. While often prescribed when PSA levels rise, he cautions that this drastic intervention is not without cost: loss of libido, cognitive decline, bone fractures, cardiovascular risks, and more. Instead of rushing into ADT at the first sign of trouble, Dr. Stephen urges a symptom-driven approach. He blends evidence, philosophy, and real-world experience to help men make smarter, more humane decisions at the edge of life and medicine.Ready to take control of your health decisions? Rethink what real prostate cancer care can look like. Tune in now: When Is Castration Worth Doing?Enjoy the podcast? Subscribe and leave a 5-star review on your favorite platforms.Dr. Stephen Petteruti is a leading Functional Medicine Physician dedicated to enhancing vitality by addressing health at a cellular level. Combining the best of conventional medicine with advancements in cellular biology, he offers a patient-centered approach through his practice, Intellectual Medicine 120. A seasoned speaker and educator, he has lectured at prestigious conferences like A4M and ACAM, sharing his expertise on anti-aging. His innovative methods include concierge medicine and non-invasive anti-aging treatments, empowering patients to live longer, healthier lives.Website: www.intellectualmedicine.com Website: https://www.theprostateprotocol.com/ YouTube: https://www.youtube.com/@intellectualmedicine LinkedIn: https://www.linkedin.com/in/drstephenpetteruti/ Instagram: instagram.com/intellectualmedine Consultation: https://www.theprostateprotocol.com/book-a-consultation Store: https://www.theprostateprotocol.com/store Community: https://www.theprostateprotocol.com/products/communities/v2/fightcancerlikeaman/home Disclaimer: The content presented in this video reflects the opinions and clinical experience of Dr. Stephen Petteruti and is intended for informational and educational purposes only. It is not medical advice and should not be used as a substitute for professional diagnosis, treatment, or guidance from your personal healthcare provider. Always consult your physician or qualified healthcare professional before making any changes to your health regimen or treatment plan.Produced by https://www.BroadcastYourAuthority.com
Please SUBSCRIBE to Psychopedia to stay on top of all new content, bonus episodes, and Investigator Slater's podcast series, Girl On Gore! Join our Patreon family for ad free episodes, exclusive content, early access to Girl On Gore, BTS, private group chats, merch discounts, and to guest co-host with Investigator Slater! www.Patreon.com/PsychopediaPod What compels a man to slice off his own penis, leg, nipple, and ear…and then turn that compulsion into a business of butchering others who claimed to want the same fate? For Marius Gustavson, a Norwegian man in London, it began with self-castration. From there, his obsession metastasized into a full-blown operation whereby he performed extreme body modifications on dozens of vulnerable men. Marius filmed the mutilations and streamed them on a pay-per-view website, where he also sold severed genitalia to paying customers. His hunting ground was the “nullo” community, composed of individuals seeking genital removal as a radical form of body modification. Many struggled with Body Integrity Identity Disorder (BIID) and turned to Gustavson for help. Instead, they got mutilation, exploitation, and a predator who feasted on their vulnerability — sometimes literally - as Gustavson went on to cannibalize some of the very testicles he cut off. This case is almost too gruesome to believe. But, it isn't just about mutilation: it's about control, sadism, consent twisted into theater, and the terrifying lengths people will go to reshape themselves when the wrong hands hold the scalpel. Revisit Episode 128: R*pe Fantasy Control Killer: Spotify Apple Podcasts Patreon: www.patreon.com/psychopediapod Instagram + TikTok: @investigatorslater @psychopediapod To learn more about listener data and our privacy practices visit: https://www.audacyinc.com/privacy-policy Learn more about your ad choices. Visit https://podcastchoices.com/adchoices
You might not be aware, but the superhero and castration fantasies are really a thing. In this episode we'll be delving into the "fear boner" arousal effect. Why things that scare you also turn you on. I hope you enjoy this fictional tale of a superhero who's in danger of losing more than just his secret identity. If you enjoy the darker side of BDSM fetishes, and would like to read the story, you can find it on my blog at https://ebonygoddessmindfuck.com/superhero-castration-fantasy/ebony-hypnodomme-bdsm-superhero-castration-fantasy/ And please remember to subscribe to the podcast, and my blog feed so you never miss an episode. You're also welcome to follow me on Twitter (X) at @NicoleReneeKali and on bluesky at @nicolereneekali.bsky.social
What do mass deportation, smashed testicles, and elite boarding schools have in common? In this episode, we take a hard look at the shockingly effective—and horrifyingly brutal—bureaucratic machine that powered the Neo-Assyrian Empire.With the rise of Tiglath-Pileser III in the 8th century BCE, Assyria transformed into one of the most ruthlessly efficient states the ancient world had ever seen. At the center of it all? Castrated boys turned bureaucrats—eunuchs molded through violence, trained in literacy, logistics, and loyalty, and unleashed across the empire as obedient tools of imperial administration.We dig deep into the Musharkisu, Assyrian deportation policy, and the Sha Reshutu, the near-invisible palace institution that raised and trained eunuchs. Along the way, we confront the politics of mass resettlement, the logic of destroying elite bloodlines, and the strange fate of disabled foreign boys who became indispensable civil servants.This isn't a story of ancient gender theory or Orientalist decadence. It's the story of state-sponsored brutality, administrative genius, and how the Assyrian Empire created a class of men without legacies—only loyalties.
Dr. Ivan de Kouchkovsky explains how radioligand therapy delivers targeted radiation to prostate cancer cells using a radioactive isotope attached to a molecule that binds to PSMA, a protein commonly expressed in these tumors. He reviews key clinical trials showing how the therapy improves survival and quality of life for men with metastatic castration-resistant prostate cancer, both after and before chemotherapy. The FDA now approves this approach for patients who have progressed on hormone therapy, even if they haven't yet received chemotherapy. De Kouchkovsky also highlights efforts to enhance effectiveness by combining therapies, increasing radiation dose, and targeting resistant or PSMA-negative cells. Diagnostic imaging plays a critical role in selecting patients most likely to benefit from treatment. Series: "Prostate Cancer Patient Conference" [Health and Medicine] [Show ID: 40810]
Dr. Ivan de Kouchkovsky explains how radioligand therapy delivers targeted radiation to prostate cancer cells using a radioactive isotope attached to a molecule that binds to PSMA, a protein commonly expressed in these tumors. He reviews key clinical trials showing how the therapy improves survival and quality of life for men with metastatic castration-resistant prostate cancer, both after and before chemotherapy. The FDA now approves this approach for patients who have progressed on hormone therapy, even if they haven't yet received chemotherapy. De Kouchkovsky also highlights efforts to enhance effectiveness by combining therapies, increasing radiation dose, and targeting resistant or PSMA-negative cells. Diagnostic imaging plays a critical role in selecting patients most likely to benefit from treatment. Series: "Prostate Cancer Patient Conference" [Health and Medicine] [Show ID: 40810]
Dr. Ivan de Kouchkovsky explains how radioligand therapy delivers targeted radiation to prostate cancer cells using a radioactive isotope attached to a molecule that binds to PSMA, a protein commonly expressed in these tumors. He reviews key clinical trials showing how the therapy improves survival and quality of life for men with metastatic castration-resistant prostate cancer, both after and before chemotherapy. The FDA now approves this approach for patients who have progressed on hormone therapy, even if they haven't yet received chemotherapy. De Kouchkovsky also highlights efforts to enhance effectiveness by combining therapies, increasing radiation dose, and targeting resistant or PSMA-negative cells. Diagnostic imaging plays a critical role in selecting patients most likely to benefit from treatment. Series: "Prostate Cancer Patient Conference" [Health and Medicine] [Show ID: 40810]
Dr. Ivan de Kouchkovsky explains how radioligand therapy delivers targeted radiation to prostate cancer cells using a radioactive isotope attached to a molecule that binds to PSMA, a protein commonly expressed in these tumors. He reviews key clinical trials showing how the therapy improves survival and quality of life for men with metastatic castration-resistant prostate cancer, both after and before chemotherapy. The FDA now approves this approach for patients who have progressed on hormone therapy, even if they haven't yet received chemotherapy. De Kouchkovsky also highlights efforts to enhance effectiveness by combining therapies, increasing radiation dose, and targeting resistant or PSMA-negative cells. Diagnostic imaging plays a critical role in selecting patients most likely to benefit from treatment. Series: "Prostate Cancer Patient Conference" [Health and Medicine] [Show ID: 40810]
This week on Ask, Tell, Confess, the gals are back with another unfiltered rollercoaster—serving up chaos, cringe, and cackles. From a man who skipped the “wash first” step with a dildo (seriously?!), to a woman's painful run-in with Crown Royal, no topic is off limits. Bunnie spills the messy details of farm life—including a rogue pond and the day she had to castrate her bull, Crunch. They wrap it all up with real talk on women's safety and a nostalgic look back at when the world felt just a little less batshit.Watch Full Episodes & More:www.dumbblondeunrated.comSee Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.
In today's episode, supported by Bayer, we had the pleasure of speaking with Alicia Morgans, MD, MPH, and Neal Shore, MD, FACS, about the FDA approval of darolutamide (Nubeqa) plus androgen deprivation therapy for patients with metastatic castration-sensitive prostate cancer (mCSPC). Morgans is the medical director of the survivorship program at Dana-Farber Cancer Institute; as well as an associate professor of medicine at Harvard Medical School, both in Boston, Massachusetts. Shore is the medical director of the Carolina Urologic Research Center. In our exclusive interview, Drs Morgans and Shore discussed the significance of this approval; key efficacy, safety, and quality of life data from the pivotal phase 3 ARANOTE trial (NCT04736199); and how this regulatory decision both opens doors for the treatment of more patients and raises questions about the optimal role of darolutamide in the management of mCSPC.
Hi friends, happy Wednesday! So you guys know I love dictators. And you ended up *LOVING* the Caesar episode… So it made me wonder what other, *older* dictators were out there who I assumed were boring but actually had these scandalous lives. And that's when I found out about a certain emperor we're gonna talk about today. Not only did he mass murder an entire group of people, but he *personally* killed just about everyone who got close to him. And you might think okay, typical bloodthirsty tyrant. Been there, done that. But … no. No one has ever matched this guy's freak. Some of the dictators we've talked about are actually failed artists. And then they take revenge on the world by taking it over. But this guy… it's almost like he didn't care about being in power at all. All he wanted to do was sing. And dance. And have insane orgies with eunuchs. But instead… he was forced by his mother to rule Rome. Today I am coming to you with the insane TRUE story of one of the world's first tyrants. This is the Dark History of NERO. I appreciate you for coming by, and tune in next week for more Dark History. I sometimes talk about my Good Reads in the show. So here's the link if you want to check it out. IDK. lol: https://www.goodreads.com/user/show/139701263-bailey ________ FOLLOW ME AROUND Tik Tok: https://bit.ly/3e3jL9v Instagram: http://bit.ly/2nbO4PR Facebook: http://bit.ly/2mdZtK6 Twitter: http://bit.ly/2yT4BLV Pinterest: http://bit.ly/2mVpXnY Youtube: http://bit.ly/1HGw3Og Snapchat: https://bit.ly/3cC0V9d Discord: https://discord.gg/BaileySarian* RECOMMEND A STORY HERE: cases4bailey@gmail.com Business Related Emails: bailey@underscoretalent.com Business Related Mail: Bailey Sarian 4400 W. Riverside Dr., Ste 110-300 Burbank, CA 91505 ________ This podcast is Executive Produced by: Bailey Sarian & Kevin Grosch and Joey Scavuzzo from Made In Network Head Writer: Allyson Philobos Writer: Katie Burris Additional Writing: Jessica Charles Research provided by: Dr. Thomas Messersmith Special thank you to our Historical Consultant: Dr. Dustin Cranford Director: Brian Jaggers Additional Editing: Julien Perez and Maria Norris Post Supervisor: Kelly Hardin Production Management: Ross Woodruff Hair: Angel Gonzalez Makeup: Bailey Sarian ________ No matter what your summer brings: Tear. Pour. Live More. Go to https://www.liquidiv.com and get 20% off your first order with code DARKHISTORY at checkout. Personal styling for everyone—get started today at https://www.stitchfix.com/darkhistory. Start listening and discover what's beyond the edge of your seat. New members can try Audible now free for 30 days and dive into a world of new thrills. Visit https://www.audible.com/DARKHISTORY or text DARKHISTORY to 500-500. Start your initial free online visit today at https://www.forhers.com/DARKHISTORY. That's https://www.forhers.com/DARKHISTORY for your personalized hair loss treatment options. Individual Results may vary. Compounded products are not FDA-approved or verified for safety, effectiveness, or quality. Prescription required. Price varies based on product and subscription plan. See website for full details, restrictions, and important safety information.
The Blasters & Blades PodcastToday we had on the indomitable Tom the Kentucky Squirrel on the show to talk with us about the new WarGate Books publisher's subscription service. We talked about all of the nerdy things that we love, then we talked about this subscription model. I had fun and I think you will too! Seriously, go check out this episode. Lend us your eyes and ears, you won't be sorry!! Join us for a fun show! We're just a couple of nerdy Army veterans geeking out on things that go "abracadabra," "pew," "zoom," "boop-beep" and rhyme with Science Fiction & Fantasy. Co-Hosts: JR Handley (Author) (Grunt)Nick Garber (Comic Book Artist) (Super Grunt)Madam Stabby Stab (Uber Fan) (Horror Nerd)We work for free, so if you wanna throw a few pennies our way there is a linked Buy Me A Coffee site where you can do so. Just mention the podcast in the comments when you donate, and I'll keep the sacred bean water boiling!Support the Show: https://www.buymeacoffee.com/AuthorJRHandley Our LinkTree: https://linktr.ee/blastersandbladespodcast Today's SponsorThe Reservist by JR Handley: https://www.amazon.com/Reservist-Galaxys-Stand-Alone-Centurion-ebook/dp/B082FST4B2/ Coffee Brand Coffee Affiliate Support the Show: https://coffeebrandcoffee.com/?ref=y4GWASiVorJZDb Discount Code: PodcastGrunts Coupon Code Gets you 10% offFollow Kentucky Squirrel on social mediaKentucky's Website: https://kentuckysquirrel.substack.com/ Kentucky's Twitter: https://x.com/kysquirrel_90 Follow WarGate Books on social mediaWGB's Website: https://www.wargatebooks.com/ WGB's Store: https://wargate.store/ WGB's Twitter: https://x.com/wargatebooks WGB's Facebook: https://www.facebook.com/wargatebooks/ WGB's Instagram: https://www.instagram.com/wargatebooks/ WGB's YouTube: https://www.youtube.com/@GalaxysEdge WGB's Podcast: https://www.wargatebooks.com/podcast WGB's GoodReads: https://www.goodreads.com/shelf/show/wargate Starbuck, Lost in Castration: https://qcurtius.com/2017/02/09/dirk-benedicts-lost-in-castration/ #scifishenanigans #scifishenaniganspodcast #bbp #blastersandblades #blastersandbladespodcast #podcast #scifipodcast #fantasypodcast #scifi #fantasy #books #rpg #comics #fandom #literature #comedy #veteran #army #armyranger #ranger #scififan #redshirts #scifiworld #sciencefiction #scifidaily #scificoncept #podcastersofinstagram #scificons #podcastlife #podcastsofinstagram #scifibooks #awardwinningscifi #newepisode #podcastersofinstagram #podcastaddict #podcast #scifigeek #scifibook #sfv #scifivisionaries #firesidechat #chat #panel #fireside #religionquestion #coffee #tea #coffeeortea #CoffeeBrandCoffee #JRHandley #NickGarber #MadamStabby #JasonAnspach #WarGateBooks #GalaxysEdgeBooks #WarGate #GalaxysEdge #KentuckySquirrel #starwars #jedi #georgelucas #lucasfilms #startrek #trekkie #firefly #serenity #browncoat #wheeloftime #wot #robertjordan #brandonsanderson #gameofthrones #got #grrm #georgerrmartin #ChroniclesofNarnia #CSLewis #steak #StarTrekTheOriginalSeries #DirkBenedict #CHiPs #JRRTolkien #Tolkien #LordOfTheRings #LotR #Velociraptor #UtahRaptor #Deinonychus #WilfordBrimley #SweetIceTea #JurassicPark #MichaelChriton #BSG #BattlestarGalactica #Marine #SpecialForces #Legionnaire #MadamGuiotine #WildMan #TyrusRechs #ContractsAndTerminations #BlainePardoe #LandAndSea #Mecha #BattleTech #PeterNealen #ColonelSaulTigh #ColonelTigh #SaulTigh #KateeSackhoff #HuntersMoonTrilogy #WaltRobillard #ChristianRummel #Narrator #TheLostFleetSeries #JackCampbell #JohnHemry #ShannaraChronicles #GenisisOfShannara #TerryBrooks #Shannara
The Blasters & Blades PodcastToday we had on the indomitable Tom the Kentucky Squirrel on the show to talk with us about the new WarGate Books publisher's subscription service. We talked about all of the nerdy things that we love, then we talked about this subscription model. I had fun and I think you will too! Seriously, go check out this episode. Lend us your eyes and ears, you won't be sorry!! Join us for a fun show! We're just a couple of nerdy Army veterans geeking out on things that go "abracadabra," "pew," "zoom," "boop-beep" and rhyme with Science Fiction & Fantasy. Co-Hosts: JR Handley (Author) (Grunt)Nick Garber (Comic Book Artist) (Super Grunt)Madam Stabby Stab (Uber Fan) (Horror Nerd)We work for free, so if you wanna throw a few pennies our way there is a linked Buy Me A Coffee site where you can do so. Just mention the podcast in the comments when you donate, and I'll keep the sacred bean water boiling!Support the Show: https://www.buymeacoffee.com/AuthorJRHandley Our LinkTree: https://linktr.ee/blastersandbladespodcast Today's SponsorThe Reservist by JR Handley: https://www.amazon.com/Reservist-Galaxys-Stand-Alone-Centurion-ebook/dp/B082FST4B2/ Coffee Brand Coffee Affiliate Support the Show: https://coffeebrandcoffee.com/?ref=y4GWASiVorJZDb Discount Code: PodcastGrunts Coupon Code Gets you 10% offFollow Kentucky Squirrel on social mediaKentucky's Website: https://kentuckysquirrel.substack.com/ Kentucky's Twitter: https://x.com/kysquirrel_90 Follow WarGate Books on social mediaWGB's Website: https://www.wargatebooks.com/ WGB's Store: https://wargate.store/ WGB's Twitter: https://x.com/wargatebooks WGB's Facebook: https://www.facebook.com/wargatebooks/ WGB's Instagram: https://www.instagram.com/wargatebooks/ WGB's YouTube: https://www.youtube.com/@GalaxysEdge WGB's Podcast: https://www.wargatebooks.com/podcast WGB's GoodReads: https://www.goodreads.com/shelf/show/wargate Starbuck, Lost in Castration: https://qcurtius.com/2017/02/09/dirk-benedicts-lost-in-castration/ #scifishenanigans #scifishenaniganspodcast #bbp #blastersandblades #blastersandbladespodcast #podcast #scifipodcast #fantasypodcast #scifi #fantasy #books #rpg #comics #fandom #literature #comedy #veteran #army #armyranger #ranger #scififan #redshirts #scifiworld #sciencefiction #scifidaily #scificoncept #podcastersofinstagram #scificons #podcastlife #podcastsofinstagram #scifibooks #awardwinningscifi #newepisode #podcastersofinstagram #podcastaddict #podcast #scifigeek #scifibook #sfv #scifivisionaries #firesidechat #chat #panel #fireside #religionquestion #coffee #tea #coffeeortea #CoffeeBrandCoffee #JRHandley #NickGarber #MadamStabby #JasonAnspach #WarGateBooks #GalaxysEdgeBooks #WarGate #GalaxysEdge #KentuckySquirrel #starwars #jedi #georgelucas #lucasfilms #startrek #trekkie #firefly #serenity #browncoat #wheeloftime #wot #robertjordan #brandonsanderson #gameofthrones #got #grrm #georgerrmartin #ChroniclesofNarnia #CSLewis #steak #StarTrekTheOriginalSeries #DirkBenedict #CHiPs #JRRTolkien #Tolkien #LordOfTheRings #LotR #Velociraptor #UtahRaptor #Deinonychus #WilfordBrimley #SweetIceTea #JurassicPark #MichaelChriton #BSG #BattlestarGalactica #Marine #SpecialForces #Legionnaire #MadamGuiotine #WildMan #TyrusRechs #ContractsAndTerminations #BlainePardoe #LandAndSea #Mecha #BattleTech #PeterNealen #ColonelSaulTigh #ColonelTigh #SaulTigh #KateeSackhoff #HuntersMoonTrilogy #WaltRobillard #ChristianRummel #Narrator #TheLostFleetSeries #JackCampbell #JohnHemry #ShannaraChronicles #GenisisOfShannara #TerryBrooks #Shannara
Today Stephanie talks about Iowa Senator Joni Ernst apologizing for saying "We're all gonna die" when asked about Medicare during a town hall meeting. She also pokes fun at HHS Secretary Robert F. Kennedy Jr.'s report which is suspected to be AI generated and sites studies that do not exist. Guest - Jody Hamilton.See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.
This week, we're heading to the Lone Star State for a story that puts the “fun” in “funeral” and the “what the actual hell” in “criminal justice.” A Texas embalmer allegedly took anatomical revenge on a dead sex offender—and let's just say, the body wasn't the only thing getting stiff that day. It's a tale of postmortem payback, questionable ethics, and the kind of crime scene that makes even seasoned detectives say, “You know what? I'm good.” Grab your gloves—we're going elbow-deep into this one.
The government says it will accept the majority of the recommendations in the report it commissioned into jail sentences. The independent review, led by ex-Conservative justice secretary David Gauke, looked at how to reduce the prison population by 2028. One of its key proposals would see well-behaved inmates only serve a third of their sentences. It would include sex offenders who had agreed to chemical castration. On the Sky News Daily, Niall Paterson speaks to political correspondent Liz Bates about what is in the plans and what the political ramifications may be for Labour. Plus, Professor Belinda Winder, who has been evaluating the government's chemical castration pilot, explains what the process involves and how effective it is. Producer: Natalie KtenaEditor: Wendy Parker
The best way to avoid going bald is… castration. Source: https://en.wikipedia.org/wiki/Castration
05-09-25 - BR - FRI - Castration Is Best Way To Avoid Going Bald - SciNews On Kissing w/Celiac DiseaseSee Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.
05-09-25 - BR - FRI - Castration Is Best Way To Avoid Going Bald - SciNews On Kissing w/Celiac DiseaseSee Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.
Dr. Rohan Garje shares the updated recommendations for the ASCO guideline on systemic therapy for patients with metastatic castration-resistant prostate cancer. He discusses the systemic therapy options for patients based on prior therapy received in the castration-sensitive and non-metastatic castration-resistant settings. He emphasizes personalizing treatment choices for each individual, considering patient-specific symptoms and signs, treatment-related toxicities, potential drug interactions, cost, and access. He also reviews recommendations on response assessment. The conversation wraps up with a discussion of potential future updates to this guideline, as the guideline transitions into a “living guideline” on mCRPC. Read the full guideline update, “Systemic Therapy in Patients with Metastatic Castration-Resistant Prostate Cancer: ASCO Guideline Update”. Transcript This guideline, clinical tools, and resources are available at www.asco.org/genitourinary-cancer-guidelines. Read the full text of the guideline and review authors' disclosures of potential conflicts of interest in the Journal of Clinical Oncology. Brittany Harvey: Hello and welcome to the ASCO Guidelines Podcast, one of ASCO's podcasts delivering timely information to keep you up to date on the latest changes, challenges and advances in oncology. You can find all the shows, including this one at asco.org/podcasts. My name is Brittany Harvey and today I'm interviewing Dr. Rohan Garje from Miami Cancer Institute Baptist Health South Florida, lead author on, “Systemic Therapy in Patients with Metastatic Castration-Resistant Prostate Cancer: ASCO Guideline Update.” Thank you for being here today, Dr. Garje. Dr. Rohan Garje: Absolutely. Thank you so much for having me, Brittany. Brittany Harvey: And then before we discuss this guideline, I'd like to note that ASCO takes great care in the development of its guidelines and ensuring that the ASCO Conflict of Interest Policy is followed for each guideline. The disclosures of potential conflicts of interest for the guideline panel, including Dr. Garje, who has joined us here today, are available online with the publication of the guideline in the Journal of Clinical Oncology, which is linked in the show notes. So then, to start on the content of this guideline, first, could you provide us an overview of the purpose of this guideline update? Dr. Rohan Garje: Sure. So ASCO has guidelines for prostate cancer and the specific guideline which we have updated for metastatic castrate-resistant prostate cancer was originally published in 2014. It's almost a decade. It's been a long time due for an update. Over the last decade, we have seen a lot of advances in the treatment of prostate cancer, specifically with regards to genomic testing, newer imaging modalities, and also the treatment landscape. Now we have newer options based on genomic targets such as PARP inhibitors, we have radiopharmaceuticals, a newer variant of chemotherapy, and also some specific indications for immunotherapy which were not addressed previously. Because all these advances have been new, it was really important for us to make an update. In 2022, we did make a rapid update with lutetium-177, but these additional changes which we have seen made it an appropriate time frame for us to proceed with a newer guideline. Brittany Harvey: Absolutely. It's great to hear about all these advances in the field to provide new options. So I'd like to next review the key recommendations from this guideline. So let's start with the overarching principles of practice that the panel outlined. What are these key principles? Dr. Rohan Garje: As a group, all the panel members came up with some ground rules: What are necessary for all our patients who are being treated for metastatic CRPC? First, the founding aspect was a definition for what is metastatic CRPC. So we defined metastatic CRPC as castrate level of testosterone with evidence of either new or progressive metastatic disease on radiological assessments or patients who have two consecutive rising PSAs in the setting of existing metastatic disease. We also emphasized on the need for germline and somatic testing for patients with metastatic prostate cancer at an earliest available opportunity because it is critical to select appropriate treatment and also right treatment for patients at the right time. And we actually have a concurrent guideline which addresses what genes to be tested and the timing. The other principles are patients should continue to receive androgen deprivation therapy or undergo surgical castration to maintain castrate level of testosterone. Now the key aspect with these guidelines is personalizing treatment choices. As you can see the evolution of treatment options for prostate cancer, the drugs that were initially developed and approved for prostate cancer were primarily in castrate-resistant settings, but now most of these drugs are being utilized in castrate-sensitive. So, when these patients develop castration resistance, the challenges are there are no appropriate particular drug-specific guidelines they meet. So, it's very important for the clinicians to be aware of what treatments have been received so far prior to castration resistance so that they can tailor the treatment to patient specific situations. In addition, prior to choosing a therapy, it is important for the physicians to consider patient specific symptoms or signs, treatment-related toxicities, potential drug interactions, cost, and also access to the drugs. There may be multiple treatment options available for the patients, but for a patient specific scenario, there may be a drug that may be more promising than the others. So, it is important to tailor the drug choices based on patients' unique circumstances. The panel also recommends to early integrate palliative and supportive care teams for symptom management and also discuss goals of care with the patient as each patient may have unique needs and it's important for physicians to address those concerns upfront in the care. The panel also suggests patients to receive RANK ligand inhibitors such as denosumab or bisphosphonates such as zoledronic acid to maintain the bone strength to prevent skeletal-related events. Finally, I would like to also emphasize this point about the lack of randomized clinical trial data for optimal sequencing of therapies for patients with metastatic CRPC. As I previously alluded, we have taken into account all ongoing clinical trials, prior published data, and came up with a format of preferred drugs based on prior treatments and, I think, by following these several clinical principles which I just mentioned, we can optimally choose and utilize best treatments for patients with metastatic CRPC. Brittany Harvey: Absolutely. These principles that you just outlined are important for optimal patient care, and then I want to touch on one of those things. You talked importantly about the treatments received so far. So in the next set of recommendations, the role of systemic therapy was stratified by the prior therapy received in the castration-sensitive and non-metastatic castration-resistant setting. So starting with what does the panel recommend for patients who are previously treated with androgen deprivation therapy alone in these previous settings and whose disease has now progressed to metastatic castration-resistant prostate cancer? Dr. Rohan Garje: There are multiple treatment options based on prior treatment received. So for patients who received only ADT for their castration-sensitive disease, the panel strongly urges to get HRR testing to check for homologous recombinant repair related changes, specifically for BRCA1 and BRCA2 mutations, because we have three studies which have really shown significant clinical benefit for patients who have BRCA1 and BRCA2 mutations with drugs such as the combination of talazoparib and enzalutamide or olaparib with abiraterone or niraparib with abiraterone. Unless we test for those mutations, we'll not be able to give these agents upfront for the patients. In the HRR testing, if patients have HRR alterations but they are in genes which are non-BRCA, the guideline panel recommends to utilize talazoparib and enzalutamide based combination therapies. Now, if they don't have HRR alterations then there are multiple treatment choices available. It could either include androgen receptor pathway inhibitors such as abiraterone with prednisone. We could also consider docetaxel chemotherapy. The alternate choices for androgen receptor pathways include enzalutamide or the newer agents such as apalutamide and docetaxel. So, as you can see there are multiple options available, but the panel definitely emphasizes to test for HRR testing because this gives patients access to more precision therapies at this point. There may be various scenarios where a unique drug may be available for a specific patient situation. For example, patients who have very limited disease burden and may have one or two metastatic lesions, after a multidisciplinary discussion, targeted local therapies such as radiation or potentially surgery could also be offered. In select patients who have very indolent disease where they are castrate-resistant based on slow rising PSA, low-volume disease or asymptomatic disease can consider sipuleucel-T. And in patients who have bone-only metastatic disease, we could also consider radium-223, which is primarily now utilized for patients who have symptomatic bone disease. Brittany Harvey: Great. I appreciate you reviewing all those options and talking about how important it is to tailor treatment to the individual patient. So then the next category of patients, what is recommended for those who have been previously treated with ADT and an androgen receptor pathway inhibitor and whose disease has now progressed to metastatic castration-resistant prostate cancer? Dr. Rohan Garje: So for patients who received ADT along with an androgen receptor pathway inhibitor, which we consider would be a most common cohort because most patients now in castration-sensitive setting are receiving androgen receptor pathway inhibitor. It was different in the past where five or six years back ADT alone was the most common treatment, but fortunately, with enough awareness and education, treatment choices have improved. Patients are now receiving ADT and ARPI as the most common choice of drug. Once again, at this point the panel emphasizes to consider HRR testing in there is enough data for us to suggest that patients who have alterations in the HRR pathway definitely will benefit with the PARP inhibitor. You know the multiple options, but specifically we speak about olaparib. And then if they are HRR-negative, we prefer patients receive agents such as docetaxel or if they are intolerant to docetaxel, consider cabazitaxel chemotherapy, options such as radium-223, and if they have a specific scenario such as MSI-high or mismatch repair deficiency, pembrolizumab could also be considered. The panel also discussed about the role of a second ARPI agent. For example, if patients progressed on one androgen receptor pathway inhibitor, the second androgen receptor pathway inhibitor may not be effective and the panel suggests to utilize alternate options before considering androgen receptor pathway inhibitor. There may be specific scenarios where a second ARPI may be meaningful, specifically, if alternate choices are not feasible for the concern of side effects or toxicities or lack of access, then a potential ARPI could be considered after progression on ARPI, but the panel definitely encourages to utilize alternate options first. Brittany Harvey: Great. Thank you for outlining those options as well for those patients. So then the next category, what is recommended for patients who have been previously treated with ADT and docetaxel? Dr. Rohan Garje: For patients who received ADT and docetaxel and were never treated with androgen receptor pathway inhibitors, the panel again emphasizes on HRR testing. If they have BRCA1 and 2 mutations, the combination therapies of talazoparib with enzalutamide, olaparib with abiraterone, or niraparib with abiraterone are all good choices. If they don't have BRCA mutations but they have other HRR mutations, the panel suggests to potentially utilize talazoparib with enzalutamide. And if they do not have any HRR alterations, the options could include androgen receptor pathway inhibitors such as abiraterone or enzalutamide. I want to emphasize that these are preferred options, but not the only options. As you can see, there are multiple options available for a particular clinical situation - so the ability of the physicians to access particular combinations, the familiarity of those drugs or the patient's unique situation where they have other medications which can potentially interact with a choice of agents. So I think based on access, based on cost and patients' concurrent illness with potential drug interactions can make one particular combination of therapy better over the other options. Brittany Harvey: Absolutely. That's key to keep in mind that access, contraindications, and cost all play a role here. So then the next set of recommendations. What are the key recommendations for patients who have previously been treated with ADT, an androgen receptor pathway inhibitor, and docetaxel who now have mCRPC? Dr. Rohan Garje: Yes. In this group, the options remain, again, broad. We utilize PSMA imaging here specifically and if they are positive on PSMA imaging, lutetium-177 is a good option. If they do not have PSMA-positive disease on PSMA imaging but if they have HRR alterations, olaparib could be utilized. And if they are negative on PSA imaging, they don't have HRR alterations, then alternate options could include cabazitaxel, radium-223. And if they have MSI-high or deficiency in mismatch repair, pembrolizumab could be utilized in this setting. Brittany Harvey: Thank you for outlining those options as well. So then next the panel addressed treatment options for de novo or treatment emergent small cell neuroendocrine carcinoma of the prostate. What are those key recommendations? Dr. Rohan Garje: Yes. This is a very high unmet need group because there are limited clinical trials, especially prospective clinical trials addressing treatment options for this group. Most of our current guidelines are always an extrapolation from lung small cell cancer based guidelines, but the panel recommends to utilize cisplatin or carboplatin along with etoposide as a preferred choice for this group. Also, an alternate option of carboplatin along with cabazitaxel could be considered for this cohort. The panel also encourages participation in clinical trials. There are numerous trials ongoing now in smaller phase studies and I think it's important for patients to consider these trials as well, because this will give them access to newer agents with potential biological targets. In addition to these agents in specific scenarios or potentially case by case basis, because we don't have prospective data, so we have made it as a select case by case basis to consider adding immunotherapy along with platinum-based chemotherapy followed by maintenance immunotherapy, which is currently a standard of care in small cell lung cancer. But the data is so limited in prostate cancer, so the panel suggested that it has to be a case by case basis only. The alternate options also include lurbinectedin, topotecan, tarlatamab upon progression on platinum-based chemotherapy. Brittany Harvey: Yes. It's important to have these recommendations in these unique situations where there is really a lack of data. So then the final set of recommendations I'd like to cover, what does the panel recommend for how clinicians should assess for response while patients are on systemic therapy and what scans are recommended for this response assessment? Dr. Rohan Garje: Yes. Again, this is another strong emphasis of the panel for global assessment of the patients. Traditionally, patients and physicians per se are heavily reliant on PSA as an accurate marker for response. This is in fact true in earlier phases of prostate cancer either in castrate-sensitive setting or localized prostate cancer setting. But as patients evolve into castrate-resistant, we don't want to heavily rely on PSA alone as a marker of response. The panel suggests to incorporate clinical response, radiological response, and also include PSA as a component, but not just rely primarily on PSA. So the panel also suggests that patients should get a bone scan and a CT scan every three to six months while on treatment to assess for appropriate response or for progression. And now one key important aspect, we are all aware about the evolving role of PSMA-based imaging with several of these new agents that are currently available. We do acknowledge these scans definitely have an important role in the care for patients with metastatic prostate cancer. Currently, the utility is primarily to select patients for lutetium-based therapy and also in situations where the traditional scans such as technitium 99 bone scan or CT scan are equivocal, then a PSMA-based imaging can be helpful. Now we are also aware that there are newer studies coming up, prospective data coming up for the role of PSMA-based imaging for response assessment. We are hoping to update the guidelines if we get access to newer data, but currently we have not recommended the utility of PSMA-based imaging for response assessments. Brittany Harvey: Understood. And I appreciate you describing where there is data here and where there's a lack of data to currently recommend. And we'll look forward to future updates of this guideline. Coming back to – at the start you mentioned how much has changed since the last guideline update. So Dr. Garje, in your view, what is the importance of this update and how will it impact both clinicians and patients with metastatic castration-resistant prostate cancer? Dr. Rohan Garje: The updated guidelines are designed to have a significant impact on clinical practice and also patient outcomes by providing clinicians with a comprehensive evidence-based framework for managing patients with metastatic CRPC. And also, by using these guidelines can make informed decisions, can select therapies tailored to patients' unique genomic status, clinical situation, where they are in the course of the cancer based on what they received previously. Also utilizing these guidelines, we can potentially improve patient outcomes, improve survival, and importantly have efficient use of healthcare resources. Brittany Harvey: Absolutely. We're always looking for ways to improve patient outcomes and survival. I want to wrap us up by talking a little bit about the outstanding questions in this field. So earlier you had mentioned about prospective data to come about PSMA PET scans, but what other outstanding questions are there for patients with metastatic castration-resistant prostate cancer? And what evidence is the panel looking forward to for future updates? Dr. Rohan Garje: We do have now rapidly evolving data specifically about the utility of the radiopharmaceutical lutetium-177 prior to chemotherapy. We are hoping that with newer data we can make some changes to the guideline based on that. We are also looking at newer drugs that are coming up in the pipeline, for example, androgen receptor degraders. We are looking at data that might potentially help based on bispecific T-cell engagers and newer radiopharmaceuticals. So I think in the next few years, we will definitely update all the guidelines again. But this time we are trying to do it more proactively. We are following a newer model. We are calling it as ‘living guidelines' where we are actually utilizing week by week updates where we look at the literature and see if there is any potential practice impacting change or publication that comes up. And we are trying to incorporate those changes as soon as they are available. That way patients and practicing physicians can get the latest information available through the guidelines as well. Brittany Harvey: That's great to hear. Yes, we'll await this data that you mentioned to continuously update this guideline and continue to improve patient outcomes for the future. So Dr. Garje, I want to thank you so much for your time to update this guideline. It was certainly a large amount of recommendations, and thank you for your time today, too. Dr. Rohan Garje: Thank you so much for having me here. And it's always nice talking to you. Brittany Harvey: And finally, thank you to our listeners for tuning in to the ASCO Guidelines podcast. To read the full guideline, go to www.asco.org/genitourinary-cancer-guidelines. You can also find many of our guidelines and interactive resources in the free ASCO Guidelines app, which is available in the Apple App Store or the Google Play Store. If you have enjoyed what you've heard today, please rate and review the podcast and be sure to subscribe so you never miss an episode. The purpose of this podcast is to educate and to inform. This is not a substitute for professional medical care and is not intended for use in the diagnosis or treatment of individual conditions. Guests on this podcast express their own opinions, experience and conclusions. Guest statements on the podcast do not express the opinions of ASCO. The mention of any product, service, organization, activity, or therapy should not be construed as an ASCO endorsement.
In 18th-century Russia, the Skoptsy Cult took religious extremism to a whole new level, believing that castration was the key to salvation. It's a wild, dark chapter in history that shows just how far people can go for their beliefs. To watch the podcast on YouTube: https://bit.ly/TheoriesOfTheThirdKindYT - Get instant access to 200+ bonus Audio episodes - Sign up here: https://theoriesofthethirdkind.supercast.com To learn more about listener data and our privacy practices visit: https://www.audacyinc.com/privacy-policy Learn more about your ad choices. Visit https://podcastchoices.com/adchoices
Welcome to BCI Cattle Chat! On this episode the experts answer your listener questions. They start by discussing what age you should castrate calves and what vaccinations could be given. Next, Dr. Brian Lubbers and Dr. Phillip Lancaster discuss feeding heifers and some of the challenges that come along with that. Finally, they discuss average… Continue reading Listener Questions: Castration, Feeding Heifers, Average Daily Gain
John Zmirak-“If you don't Rejoice at the Defeat of the Party of Child Castration, Open Borders, Fentanyl, Treason, Censorship and forced Vaccination, You gotta Check your Loyalty” The Eric Metaxas Show John Zmirak Mar 06 2025 Other Episodes Big Bad John is back with Eric to discuss Donald Trump's Address to Congress, Ukraine and Zelensky Charity Mentioned- Food For the Poor https://foodforthepoor.org/ Help us serve the poorest of the poor Food For The Poor began in 1982 in Jamaica. Today, our interdenominational Christian ministry serves the poor in primarily 17 countries throughout the Caribbean and Latin America. Thanks to our faithful donors, we are able to provide food, housing, healthcare, education, fresh water, emergency relief, micro-enterprise solutions and much more. We are proud to have fed millions of people and provided more than 15.7 billion dollars in aid. Our faith inspires us to be an organization built on compassion, and motivated by love. Our mission is to bring relief to the poorest of the poor in the countries where we serve. We strive to reflect God's unconditional love. It's a sacrificial love that embraces all people regardless of race or religion. We believe that we can show His love by serving the “least of these” on this earth as Christ challenged us to do in Matthew 25. We pray that by God's grace, and with your support, we can continue to bring relief to the suffering and hope to the hopeless. Report on Food For the Poor by Charity Navigator https://www.charitynavigator.org/ein/592174510 ----------------------------------------------------------------------------------------------- John Zmirak makes his weekly appearance and covers current events and shares recent articles available at- https://stream.org/author/johnzmirak/ Watch Eric Metaxas on Rumble- https://rumble.com/c/TheEricMetaxasRadioShow The Eric Metaxas Show- https://metaxastalk.com/podcasts/ Eric Metaxas Show on Apple Podcasts- https://podcasts.apple.com/us/podcast/the-eric-metaxas-show/id991156680 Check out- Socrates in the City Find All of John Zmirak Articles at- https://stream.org/author/johnzmirak/ John Zmirak is a senior editor at The Stream and author or co-author of ten books, including The Politically Incorrect Guide to Immigration and The Politically Incorrect Guide to Catholicism. He is co-author with Jason Jones of “God, Guns, & the Government.” John Zmirak's new book: No Second Amendment, No First by John Zmirak Available March 19, 2024 Today's Left endlessly preaches the evils of “gun violence." It is a message increasingly echoed from the nation's pulpits, presented as common-sense decency and virtue. Calls for “radical non-violence” are routinely endowed with the imprimatur of religious doctrine. But what if such teachings were misguided, even damaging? What if the potential of a citizenry to exercise force against violent criminals and tyrannical governments is not just compatible with church teaching, but flows from the very heart of Biblical faith and reason? What if the freedoms we treasure are intimately tied to the power to resist violent coercion? This is the long-overdue case John Zmirak makes with stunning clarity and conviction in No Second Amendment, No First. A Yale-educated journalist and former college professor, Zmirak shows how the right of self-defense against authoritarian government was affirmed in both the Old and New Testaments, is implied in Natural Law, and has been part of Church tradition over the centuries. 4 days ago The Brew: Gavin Newsom Throws Bearded ‘Female' Athletes Under the Campaign Bus 4 days ago President Trump Tells Congress: ‘I Don't Make the Natural Law. I Just Enforce It.' 6 days ago The Brew: Will We Choose the Logos or the Antichrist? 1 week ago The Brew: Did Zelensky's Crass Blustering Save America from Future Stupid Wars? Let's Buy That Man a New Piano! 2 weeks ago The Brew: Screwtape Cordially Invites Us to Join Him in the Inferno by the Left Entrance … or the Right 2 weeks ago The Brew: CNN Blandly Reports That Anti-Trump Deep State Spooks May Hand U.S. Secrets to Foreign Powers 2 weeks ago The Brew: RFK, Jr., Says COVID Panic Was an Orchestrated Plan to Establish Totalitarianism 3 weeks ago The Brew: War Party Groupthink Over Ukraine Is Crumbling. Could Peace Break Out Soon? 3 weeks ago The Brew: Did the COVID Panic Wake Up the West and Shatter Leftist Groupthink? 3 weeks ago The Brew: CBS News Tags Along as German Secret Police Terrorize Citizens for Social Media Posts 3 weeks ago Why Do Progressive Christians Like Pope Francis Want to Burn the West Down? HELP ACU SPREAD THE WORD! Please go to Apple Podcasts and give ACU a 5 star rating. Apple canceled us and now we are clawing our way back to the top. Don't let the Leftist win. Do it now! Thanks. Also Rate us on any platform you follow us on. It helps a lot. Forward this show to friends. Ways to subscribe to the American Conservative University Podcast Click here to subscribe via Apple Podcasts Click here to subscribe via RSS You can also subscribe via Stitcher FM Player Podcast Addict Tune-in Podcasts Pandora Look us up on Amazon Prime …And Many Other Podcast Aggregators and sites ACU on Twitter- https://twitter.com/AmerConU . Warning- Explicit and Violent video content. Please help ACU by submitting your Show ideas. Email us at americanconservativeuniversity@americanconservativeuniversity.com Endorsed Charities -------------------------------------------------------- Pre-Born! Saving babies and Souls. https://preborn.org/ OUR MISSION To glorify Jesus Christ by leading and equipping pregnancy clinics to save more babies and souls. WHAT WE DO Pre-Born! partners with life-affirming pregnancy clinics all across the nation. We are designed to strategically impact the abortion industry through the following initiatives:… -------------------------------------------------------- Help CSI Stamp Out Slavery In Sudan Join us in our effort to free over 350 slaves. Listeners to the Eric Metaxas Show will remember our annual effort to free Christians who have been enslaved for simply acknowledging Jesus Christ as their Savior. As we celebrate the birth of Christ this Christmas, join us in giving new life to brothers and sisters in Sudan who have enslaved as a result of their faith. https://csi-usa.org/metaxas https://csi-usa.org/slavery/ Typical Aid for the Enslaved A ration of sorghum, a local nutrient-rich staple food A dairy goat A “Sack of Hope,” a survival kit containing essential items such as tarp for shelter, a cooking pan, a water canister, a mosquito net, a blanket, a handheld sickle, and fishing hooks. Release celebrations include prayer and gathering for a meal, and medical care for those in need. The CSI team provides comfort, encouragement, and a shoulder to lean on while they tell their stories and begin their new lives. Thank you for your compassion Giving the Gift of Freedom and Hope to the Enslaved South Sudanese -------------------------------------------------------- Food For the Poor https://foodforthepoor.org/ Help us serve the poorest of the poor Food For The Poor began in 1982 in Jamaica. Today, our interdenominational Christian ministry serves the poor in primarily 17 countries throughout the Caribbean and Latin America. Thanks to our faithful donors, we are able to provide food, housing, healthcare, education, fresh water, emergency relief, micro-enterprise solutions and much more. We are proud to have fed millions of people and provided more than 15.7 billion dollars in aid. Our faith inspires us to be an organization built on compassion, and motivated by love. Our mission is to bring relief to the poorest of the poor in the countries where we serve. We strive to reflect God's unconditional love. It's a sacrificial love that embraces all people regardless of race or religion. We believe that we can show His love by serving the “least of these” on this earth as Christ challenged us to do in Matthew 25. We pray that by God's grace, and with your support, we can continue to bring relief to the suffering and hope to the hopeless. Report on Food For the Poor by Charity Navigator https://www.charitynavigator.org/ein/592174510 -------------------------------------------------------- Disclaimer from ACU. We try to bring to our students and alumni the World's best Conservative thinkers. All views expressed belong solely to the author and not necessarily to ACU. In all issues and relations, we hope to follow the admonitions of Jesus Christ. While striving to expose, warn and contend with evil, we extend the love of God to all of his children. -----------------------------------------------------------------------------------------
Heaven's Gate wasn't just another doomsday cult—it was a chilling fusion of sci-fi, Christian prophecy, and absolute control that led 39 people to their final, otherworldly exit.IN THIS EPISODE: Following an anonymous tip, police enter a mansion in Rancho Santa Fe, an exclusive suburb of San Diego, California, and discover 39 victims of a mass suicide. The deceased–21 women and 18 men of varying ages–were all found lying peaceably in matching dark clothes and Nike sneakers and had no noticeable signs of blood or trauma. It was later revealed that the men and women were members of the “Heaven's Gate” religious cult, whose leaders preached that suicide would allow them to leave their bodily “containers” and enter an alien spacecraft hidden behind the Hale-Bopp comet. *** PLUS, the creepy true-crime story of two men who were caught trying to steal the body of the 16th President of the United States, Abraham Lincoln. But that is by no means the end of this story full of twists, turns, myths, and conspiracies.CHAPTERS & TIME STAMPS (All Times Approximate)…00:00:00.000 = Heaven's Gate, Part 1 00:01:10.830 = Show Open00:02:53.580 = Heaven's Gate, Part 200:10:00.270 = Heaven's Gate, Part 300:24:29.552 = Heaven's Gate, Part 400:45:19.851 = Stealing Lincoln's Bones00:58:30.720 = Show Close, Verse, and Final ThoughtSOURCES AND RESOURCES FROM THE EPISODE…Episode Page at WeirdDarkness.com (includes list of sources): https://weirddarkness.com/HeavensGate“Heavens Gate” by Rolling Stone: http://bit.ly/WeirdDarkness2D7tbeZ, Ranker: http://bit.ly/weirddarkness2UIsK4O, and History.com: http://bit.ly/WeirdDarkness2G3uqfN“Stealing Lincoln's Bones” by Troy Taylor: https://www.americanhauntingsink.com/stealing-lincolns-bones=====Darkness Syndicate members get the ad-free version. https://weirddarkness.com/syndicateInfo on the next LIVE SCREAM event. https://weirddarkness.com/LiveScreamInfo on the next WEIRDO WATCH PARTY event. https://weirddarkness.com/TV=====(Over time links seen above may become invalid, disappear, or have different content. I always make sure to give authors credit for the material I use whenever possible. If I somehow overlooked doing so for a story, or if a credit is incorrect, please let me know and I will rectify it in these show notes immediately. Some links included above may benefit me financially through qualifying purchases.)= = = = ="I have come into the world as a light, so that no one who believes in me should stay in darkness." — John 12:46= = = = =WeirdDarkness® is a registered trademark. Copyright ©2025, Weird Darkness.=====Originally aired: November 28, 2021
Happy Valentine's Day! Let's talk about love. Kind of. But not really. Not all actually. Let's instead, talk about how and why we humans have castrated each other and ourselves throughout human history. This one's not for the squeamish. But, I also can't remember laughing this often in any other recent episode! For Merch and everything else Bad Magic related, head to: https://www.badmagicproductions.com
This week, we're in Utah discussing a horrific attack on a wagon train. Then, we'll talk about a serial killer who has traveled across the country, killing and sexually mutilating young men. Buckle up and join us on this dark and twisted ride through the Beehive State. You may now join us on Patreon or buy us a Cocktail. Be sure to subscribe on Apple and leave a review, or, email us at unitedstatesofmurder@gmail.com Follow us on Facebook, Instagram, and Twitter! Sources: Meadows Massacre, PBS: American Experience, Smithsonian Magazine, American Massacre: The Tragedy at Mountain Meadows, Deseret News, Marty James Shook - Utah DPS, Medium, Unresolved, The I-80 Hitchhiker Murders: Who Killed Wayne Rifendifer & Marty Shook? Music by Pixabay
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