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13 episodes with PTX
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2 episodes with PTX
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2 episodes with PTX
2 episodes with PTX
2 episodes with PTX
2 episodes with PTX
Középszerűvé válhat az Apple? ITBusiness 2025-03-14 05:15:15 Infotech Apple WWDC Az Apple múlt pénteken jelentette be, hogy az Apple Intelligence "személyre szabott Siri" funkciói – amelyek eredetileg még a júniusi WWDC előtt érkeztek volna – csak a következő évben jelennek meg. Meglepő volt, mégis teljesen kiszámítható lehetett volna, ha figyelmesebbek vagyunk. Emelkedik és reng a föld a Nápolyi-öböl partvidékén Telex 2025-03-14 10:34:37 Tudomány Olaszország Vulkán Több százezren élnek itt egy hatalmas, ősi vulkán kráterének peremén, ami 500 éve nem tört ki, de most egyre aktívabb. Jól vizsgáztak a Marsnál a BME kutatói által kalibrált kamerák Helló Sajtó! 2025-03-14 08:05:00 Tudomány Világűr Kamera Mars BME Az Európai Űrügynökség (ESA) Hera űrszondája március 12-én mintegy 5000 kilométerre megközelítette a Marsot és hintamanővert hajtott végre. A fő cél az űrszonda felgyorsítása volt, de az ESA csapata kihasználta a bolygó közelségét az optikai kamerák tesztelésére és pár fotó készítésére is. Lenyomta az iPhone-t, felért a csúcsra: ez most a világ legjobb okostelefonja Startlap Vásárlás 2025-03-14 11:49:47 Mobiltech Spanyolország Telefon Kiállítás Apple Okostelefon Barcelona iPhone Hamarosan véget ér a barcelonai Mobile World Congress kiállítás: az esemény során az év legnagyobb technológiai újításait díjazták. Rejtélyes rádiójelek érkeznek a világűr egy eddig ismeretlen részéről ICT Global 2025-03-14 05:03:04 Infotech Világűr Egy évtizede, két óránként rejtélyes rádiójelek érkeznek egy ismeretlen forrásból a Nagy Göncölszekér irányából. A kutatók ennyi év után, most nagy áttörésről számolhatnak be. Összefogott a Schneider Electric és az Atmen a legjobb zöld minősítési folyamatok érdekében Digital Hungary 2025-03-14 13:41:00 Infotech Üzemanyag Tankolás Schneider Electric Minden eddiginél gyorsabban és egyszerűbben szerezhetik meg a zöld tanúsítványokat a hidrogén- és e-üzemanyagok gyártói a Schneider Electric és az Atmen együttműködésének köszönhetően. A két vállalat egy szabványosított megoldást dolgoz ki a PtX iparágak fenntarthatósági megfelelésének támogatása érdekében. Darabjaira hullott a magyar társadalom Qubit 2025-03-14 08:52:13 Tudomány Társadalomkutatás Szociológia Kovách Imre szociológus és kutatótársai csütörtökön bemutatott, nagyszabású munkájából olyan ország képe bontakozik ki, ahol egyes csoportok elégedetten, polgárosodva élik az életüket, míg más nagy méretű csoportok leszakadtak és elmagányosodtak. A politika ezeket az egyenlőtlenségeket kihasználja és konzerválja, hiszen a polarizáció fenntartása és Első látásra beleszerettünk az Asus új gépébe – aztán megismertük Index 2025-03-14 15:24:00 Gaming Infotech Tajvan Asus Az élet értelmét is könnyebb megmagyarázni, mint azt, miért létezik a tajvaniak új masinája. Teszten a ROG Flow Z13. Már nem extra az új autóknál a mobilkapcsolat HWSW 2025-03-14 09:42:35 Infotech A tavaly eladott új autók háromnegyedében volt mobilkommunikációs modul - a technológia főleg az elektromos autóknál népszerű. Száguld a robotika, AI-modellekkel száll be a Google IT café 2025-03-14 10:04:00 Infotech Google Robot Kilőtt a robotikai szektor, a Google pedig két új AI-modellel szolgálná ki az ágazatot. A világháló atyja tudni akarja, "kinek dolgozik a mesterséges intelligencia" Blikk 2025-03-14 05:51:00 Infotech Mesterséges intelligencia Tim Berners-Lee, a World Wide Web, azaz az internet megálmodója szerint a vállalatok évtizedekkel ezelőtt együttműködtek a nyílt internet létrehozásában. Ez a generatív mesterséges intelligencia esetében viszont nem történik meg. Akkor pedig kinek a hasznára és érdekében dolgozik az AI? Ezt a kérdést sürgősen tisztázni kell! A NASA Spherex űrtávcsöve elindítja tudományos küldetését 10perc.hu 2025-03-14 11:45:00 Infotech Világűr NASA A NASA SPHEREx űrtávcsöve megkezdi tudományos munkáját, hogy feltárja az univerzum keletkezését és az ősrobbanás utáni eseményeket. Növelni kell az ellenállóképességet a kiberbűnözés ellen Növekedés 2025-03-14 14:17:00 Gazdaság Interjú Kiberbiztonság Hacker Kibertámadás Wittinghof Tamás A sikeres kibertámadást elszenvedő kis- és közepes vállalkozások hatvan százaléka a támadást követő hat hónapon belül befejezi a tevékenységét. A Mastercard néhány héten belül egy hiánypótló elemzést publikál a kiberbiztonság lokális helyzetéről. Interjú Wittinghoff Dániellel, a Mastercard kiberbiztonsági termékekért felelős üzletfejlesztési igazga A további adásainkat keresd a podcast.hirstart.hu oldalunkon.
Középszerűvé válhat az Apple? ITBusiness 2025-03-14 05:15:15 Infotech Apple WWDC Az Apple múlt pénteken jelentette be, hogy az Apple Intelligence "személyre szabott Siri" funkciói – amelyek eredetileg még a júniusi WWDC előtt érkeztek volna – csak a következő évben jelennek meg. Meglepő volt, mégis teljesen kiszámítható lehetett volna, ha figyelmesebbek vagyunk. Emelkedik és reng a föld a Nápolyi-öböl partvidékén Telex 2025-03-14 10:34:37 Tudomány Olaszország Vulkán Több százezren élnek itt egy hatalmas, ősi vulkán kráterének peremén, ami 500 éve nem tört ki, de most egyre aktívabb. Jól vizsgáztak a Marsnál a BME kutatói által kalibrált kamerák Helló Sajtó! 2025-03-14 08:05:00 Tudomány Világűr Kamera Mars BME Az Európai Űrügynökség (ESA) Hera űrszondája március 12-én mintegy 5000 kilométerre megközelítette a Marsot és hintamanővert hajtott végre. A fő cél az űrszonda felgyorsítása volt, de az ESA csapata kihasználta a bolygó közelségét az optikai kamerák tesztelésére és pár fotó készítésére is. Lenyomta az iPhone-t, felért a csúcsra: ez most a világ legjobb okostelefonja Startlap Vásárlás 2025-03-14 11:49:47 Mobiltech Spanyolország Telefon Kiállítás Apple Okostelefon Barcelona iPhone Hamarosan véget ér a barcelonai Mobile World Congress kiállítás: az esemény során az év legnagyobb technológiai újításait díjazták. Rejtélyes rádiójelek érkeznek a világűr egy eddig ismeretlen részéről ICT Global 2025-03-14 05:03:04 Infotech Világűr Egy évtizede, két óránként rejtélyes rádiójelek érkeznek egy ismeretlen forrásból a Nagy Göncölszekér irányából. A kutatók ennyi év után, most nagy áttörésről számolhatnak be. Összefogott a Schneider Electric és az Atmen a legjobb zöld minősítési folyamatok érdekében Digital Hungary 2025-03-14 13:41:00 Infotech Üzemanyag Tankolás Schneider Electric Minden eddiginél gyorsabban és egyszerűbben szerezhetik meg a zöld tanúsítványokat a hidrogén- és e-üzemanyagok gyártói a Schneider Electric és az Atmen együttműködésének köszönhetően. A két vállalat egy szabványosított megoldást dolgoz ki a PtX iparágak fenntarthatósági megfelelésének támogatása érdekében. Darabjaira hullott a magyar társadalom Qubit 2025-03-14 08:52:13 Tudomány Társadalomkutatás Szociológia Kovách Imre szociológus és kutatótársai csütörtökön bemutatott, nagyszabású munkájából olyan ország képe bontakozik ki, ahol egyes csoportok elégedetten, polgárosodva élik az életüket, míg más nagy méretű csoportok leszakadtak és elmagányosodtak. A politika ezeket az egyenlőtlenségeket kihasználja és konzerválja, hiszen a polarizáció fenntartása és Első látásra beleszerettünk az Asus új gépébe – aztán megismertük Index 2025-03-14 15:24:00 Gaming Infotech Tajvan Asus Az élet értelmét is könnyebb megmagyarázni, mint azt, miért létezik a tajvaniak új masinája. Teszten a ROG Flow Z13. Már nem extra az új autóknál a mobilkapcsolat HWSW 2025-03-14 09:42:35 Infotech A tavaly eladott új autók háromnegyedében volt mobilkommunikációs modul - a technológia főleg az elektromos autóknál népszerű. Száguld a robotika, AI-modellekkel száll be a Google IT café 2025-03-14 10:04:00 Infotech Google Robot Kilőtt a robotikai szektor, a Google pedig két új AI-modellel szolgálná ki az ágazatot. A világháló atyja tudni akarja, "kinek dolgozik a mesterséges intelligencia" Blikk 2025-03-14 05:51:00 Infotech Mesterséges intelligencia Tim Berners-Lee, a World Wide Web, azaz az internet megálmodója szerint a vállalatok évtizedekkel ezelőtt együttműködtek a nyílt internet létrehozásában. Ez a generatív mesterséges intelligencia esetében viszont nem történik meg. Akkor pedig kinek a hasznára és érdekében dolgozik az AI? Ezt a kérdést sürgősen tisztázni kell! A NASA Spherex űrtávcsöve elindítja tudományos küldetését 10perc.hu 2025-03-14 11:45:00 Infotech Világűr NASA A NASA SPHEREx űrtávcsöve megkezdi tudományos munkáját, hogy feltárja az univerzum keletkezését és az ősrobbanás utáni eseményeket. Növelni kell az ellenállóképességet a kiberbűnözés ellen Növekedés 2025-03-14 14:17:00 Gazdaság Interjú Kiberbiztonság Hacker Kibertámadás Wittinghof Tamás A sikeres kibertámadást elszenvedő kis- és közepes vállalkozások hatvan százaléka a támadást követő hat hónapon belül befejezi a tevékenységét. A Mastercard néhány héten belül egy hiánypótló elemzést publikál a kiberbiztonság lokális helyzetéről. Interjú Wittinghoff Dániellel, a Mastercard kiberbiztonsági termékekért felelős üzletfejlesztési igazga A további adásainkat keresd a podcast.hirstart.hu oldalunkon.
What started out as a quiet day turned mostly lower by Wednesday's close as we saw pressure in wheat, soybeans and corn along with the hog market. Was it a money flow issue or something else at play on the day? Mike Zuzolo with Global Commodity Analytics joins us for analysis of the grain, livestock and macro markets on today's show. Find more online at https://www.globalcommresearch.com. Also in Segment Four, we listen to a conversation from the National Farm Machinery Show with Bryce Baker, head of marketing for Precision Planting and PTx.
The global oncology drug market, valued at USD 231.56 billion in 2024, is expected to grow to USD 532.91 billion by 2031, driven by demand for targeted therapies, biomarker-based treatments, and immunotherapies. Several ASX-listed companies are contributing to this innovation: Arovella Therapeutics Ltd: Developing its invariant Natural Killer T (iNKT) cell therapy platform to treat blood cancers and solid tumours. Lead product ALA-101 uses CAR19-iNKT cells to target the CD19 antigen. The company recently raised $20 million to fund a phase 1 trial for CD19-positive blood cancers. Race Oncology Ltd: Focused on its lead asset, bisantrene, a small-molecule chemotherapeutic with reduced cardiotoxicity. A reformulated version, RC220, is being developed to meet unmet oncology needs. Imugene Ltd: Advancing immuno-oncology therapies, including azer-cel, an off-the-shelf CAR T therapy targeting CD19 for blood cancers, B-cell vaccine candidates, and CF33 oncolytic virotherapy, which combines engineered viruses with immunotherapies for solid tumours. Prescient Therapeutics Ltd: Developing personalised cancer treatments with technologies from institutions like Yale and Oxford. Lead drug PTX-100 has FDA Orphan Drug Designation for T-cell lymphomas. Its OmniCAR and CellPryme platforms enhance CAR-T therapies for improved efficacy and adaptability. These companies exemplify the growth and innovation occurring within the oncology sector. #ProactiveInvestors #ASX #OncologyMarket #ASXCompanies #ArovellaTherapeutics #RaceOncology #Imugene #PrescientTherapeutics #CancerResearch #ImmunoOncology #CellTherapy #TargetedTherapies #CAR_T #PersonalisedMedicine #CancerCare #BiotechNews #OncologyInnovation #GlobalHealthcare #ClinicalTrials #FDAApproval #SolidTumours #BloodCancers
Proactive's Tylah Tully breaks down ‘Just the Facts' of the latest news from Prescient Therapeutics Ltd (ASX:PTX, OTC:PSTTF). The company has received US FDA clearance to proceed with Phase 2 clinical trials for its Ras pathway inhibitor, PTX-100. This study will focus on relapsed and refractory cutaneous T-cell lymphomas (r/r CTCL). The decision follows the completion of a Phase 1b trial involving 19 T-cell lymphoma patients, which demonstrated an excellent safety profile and a 42% overall response rate. Among evaluable r/r CTCL patients, five of seven experienced clinical benefits. The global Phase 2 trial will enrol 115 patients across 15 sites in Australia, the US and Europe. It will consist of two parts: dose optimisation and efficacy assessments. Primary endpoints include objective response rate, with secondary metrics focusing on progression-free survival, overall survival, safety, and quality of life. The company describes FDA clearance as a transformative milestone, reflecting years of preclinical and clinical development. Prescient aims to collaborate with global CTCL experts to deliver a safe and effective therapy for this area of unmet need. The announcement drove a 55% surge in the company's shares. #ProactiveInvestors #PrescientTherapeutics #ASX #OTC #PTX100 #FDAApproval #ClinicalTrials #OncologyResearch #TCellLymphoma #CTCL #CancerTreatment #OrphanDrug #Phase2Trial #GlobalTrial #DrugDevelopment #MedicalInnovation #PatientCare #RasPathway #CutaneousLymphoma #BiotechNews #ClinicalResearch #ASXStocks #PharmaInnovation
AMD has 24 Core Ryzen INCOMING…and Nvidia, RADEON, and Intel GPUs are about to launch! [SPON: Use "brokensilicon“ at CDKeyOffer's Black Friday Sale to get Win 11 Pro for $23: https://www.cdkeyoffer.com/cko/Moore11 ] [SPON: Use “brokensilicon” to get $30 OFF the Minisforum V3 3-in-1 Tablet: https://shrsl.com/4rt3x ] 0:00 Mastering the Swivel! (Intro Banter) 2:20 PlayStation 6 Naming 6:47 XBOX getting Buggier (?), 9800X3D Supply (Corrections) 14:51 Next-Gen GPU Release Dates CONFIRMED! 25:32 Will RDNA 4 be the “next Polaris”? USB-C Support? 30:55 Intel ARC B570 10GB Leaks 37:49 Nvidia ends Lovelace Production 40:08 Strix Halo Low Power Specs Leaked 48:46 Zen 6 Medusa Point (And Ridge?) Specs Leaked! 54:44 How should AMD segment the Zen 6 lineup? 1:10:39 Qualcomm loses interest in Intel amongst Funding Cuts 1:17:36 Is an Intel-AMD merger possible? 1:24:18 TSMC 2nm Okayed for USA, PS2 160M, PSP2 Confirmed, 4090 Ti Surfaces (Wrap-up) 1:30:45 Nvidia Orin, RTX to PTX, AMD Smartphones, 200K Subs (Final RM) https://www.amazon.co.uk/Best-Sellers-CPUs/zgbs/computers/430515031 https://youtu.be/zipQWc2AzsU https://www.techpowerup.com/329193/intel-arc-b580-gpu-leaked-ahead-of-imminent-launch https://www.tomshardware.com/pc-components/gpus/nvidia-blackwell-rtx-50-series-gpus-everything-we-know https://www.pcgamesn.com/nvidia/geforce-rtx-5090-launch-leak-inno3d https://videocardz.com/newz/gunnir-arc-battlemage-gpus-to-be-revealed-on-december-4th https://videocardz.com/newz/intel-arc-b570-specs-leaked-18-xe2-cores-10gb-memory-and-pcie-4-0x8 https://amzn.to/4g7aIPy https://amzn.to/49wfXqh https://www.newegg.com/p/27N-0002-001G2 https://www.tomshardware.com/pc-components/gpus/nvidia-warns-of-gaming-gpu-shortage-this-quarter-recovery-in-early-2025-chipmaker-rakes-in-record-profits-as-net-income-soars-by-109-percent-yoy https://nvidianews.nvidia.com/news/nvidia-announces-financial-results-for-third-quarter-fiscal-2025 https://youtu.be/h5dDn8nzvAw https://youtu.be/h5dDn8nzvAw https://www.guru3d.com/story/amd-zen-6-medusa-ridge-processor-leak-reveals-12core-ccd-architecture/ https://www.fudzilla.com/news/graphics/60169-zen-6-medusa-ridge-processor-leaked https://www.tomshardware.com/tech-industry/qualcomm-reportedly-loses-interest-in-intel-takeover https://www.trendforce.com/news/2024/11/26/news-qualcomms-interest-in-acquiring-intel-reportedly-fades-due-to-the-deals-complexity/ https://www.tomshardware.com/tech-industry/us-plans-to-shrink-intels-usd8-5b-chips-funding-to-below-usd8b-restructuring-takes-into-account-chipmakers-usd3-5b-contract-to-make-chips-for-the-military https://www.reuters.com/technology/intels-786-billion-subsidy-deal-restricts-sale-its-manufacturing-unit-2024-11-28/ https://wccftech.com/tsmc-can-shift-advanced-2nm-manufacturing-to-us-after-2025-insinuates-taiwanese-minister/ https://www.techradar.com/pro/Only-about-720000-Qualcomm-Snapdragon--laptops-sold-since-launch https://x.com/lithos_graphein/status/1858485988080640051 https://videocardz.com/newz/samsung-to-present-gddr7-memory-with-42-5-gb-s-speed-at-isscc-2025 https://www.tomshardware.com/pc-components/cpus/amd-crafts-custom-epyc-cpu-for-microsoft-azure-with-hbm3-memory-cpu-with-88-zen-4-cores-and-450gb-of-hbm3-may-be-repurposed-mi300c-four-chips-hit-7-tb-s https://www.techspot.com/news/105744-sony-confirms-playstation-2-sales-top-160m-cementing.html https://www.techpowerup.com/329307/sony-handheld-gaming-console-reportedly-coming-for-steam-deck-nintendo-switch-market-share https://videocardz.com/newz/prototype-geforce-rtx-4090-ti-gpu-has-been-found-in-computer-junk-bin-massive-quad-slot-design-and-rotated-pcie
In today's show Dustin speaks with Dr. Greg Tylka at the SCN lab tour at Iowa State, Mark wraps up his conversation with Seth Crawford of PTx, and Andy speaks with Ron Calhoun of Nutrien Ag Solutions.
In today's show, Mark visits with Seth Crawford of PTx to discuss precision technology, Andy talks crop protection with Ron Geis of Corteva, and Riley finishes his conversation on farm succession planning with Matt Roberts of Syverson Strege.
Finding skilled labor is one of the big challenges facing America's farmers and ranchers. In this edition of Innovations in Agriculture, Meghan Grebner talks with Colton Rathman with PTx about OutRun - a self-contained retrofit kit that enables autonomous grain cart operation with John Deere 8R tractors that are equipped with IVT.See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.
Brownfield's Meghan Grebner interviews Seth Crawford, senior vice president and general manager for PTx. See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.
Primera hora de Visión Global que empezamos con el análisis de mercados en el que nos acompaña José Luis Herrera, analista independiente. Con él hablamos de la jornada en los mercados. En un día en el que Wall Street permanece cerrado por la celebración del día de la Independencia. Hablamos también del impacto de la situación política en el Reino Unido y Francia sobre la renta variable europea. Después, en nuestra sección dedicada a la 'gestión del patrimonio' hablamos con Pilar Bravo, directora de desarrollo de negocio en Finaccess sobre el fondo NSF Climate Change. Después, en nuestra sección 'universo renovable' hablamos de la llegada a España de StrategHy, una firma de consultoría estratégica especializada en hidrógeno verde y PtX. Terminamos con nuestra sección 'sector agro' en la que hablamos del cava.
Prescient Therapeutics Ltd (ASX:PTX, OTC:PSTTF) CEO and managing director Steven Yatomi-Clarke sits down with Jonathan Jackson in the Proactive studio ahead of a presentation of the results of its PTX-100 Phase 1b study at the 15th Annual T-Cell Lymphoma Forum (TCLF) in California from June 6 to 8. The Phase 1b study targeted patients with relapsed and refractory T-cell lymphomas (r/r TCLs) and successfully met its primary objectives of demonstrating safety and determining pharmacokinetics and pharmacodynamics. Additionally, the study showed a promising preliminary efficacy with a 45% overall response rate, where five out of 11 evaluable patients responded positively to the treatment. T-cell lymphomas are a rare type of non-Hodgkin lymphoma, classified as an orphan disease with about 30,000 cases. PTX-100 has received Orphan Drug Designation from the US FDA, highlighting the need for more effective treatments for TCLs, particularly for relapsed and refractory cases. The T-Cell Lymphoma Forum is a specialised conference focused on advancements in TCL treatment, bringing together clinicians, scientists and industry professionals. Yatomi-Clarke, emphasised the importance of this platform for sharing critical research and the significance of PTX-100 in addressing an unmet medical need. The company plans to advance to a Phase 2 trial in r/r TCL, expected to commence in Q3 2024. #ProactiveInvestors #PrescientTherapeutics #ASX #OTC #PTX100 #TCLF #TCellLymphoma #OncologyResearch #ClinicalTrial #Phase1bStudy #OrphanDrug #USFDA #Pharmacokinetics #Pharmacodynamics #CancerTreatment #MedicalResearch #Hematology #RareDisease #DrugDevelopment #HealthcareInnovation #StevenYatomiClarke #MilesPrince #invest #investing #investment #investor #stockmarket #stocks #stock #stockmarketnews
Tech issues won't stop this shortened show by 40 minutes or so. Sorry about that! Hello folks, welcome to the independent spotlight. On this program, we're going to feature women or groups with women in it like PTX as its shortened to. I hope that you'll join me, as I did buy some new stuff too, about $45 or $50 in material. Set 2 of this program is set 4 podcast wise with three because of a technical issue. O all days, right? Set 1: Pentatonix (PTX) is a male and female group who does Acappella. We start with three by them before we play our newest pieces of material. Pentatonix Attention 02:50 Pentatonix New Rules x Are You That Somebody? 02:48 Pentatonix Despacito x Shape Of You 03:15 Set 2: This set is replaced with set 4 in the podcast due to a technical issue I found after the fact. Sorry about that! Sherry Finzer North Star 04:14 Sherry Finzer Brilliance 04:08 Sherry Finzer Soliloquy 03:50 Sherry Finzer Over Clouds and Mountain Tops 04:02 Sherry Finzer Safe Haven 02:41 Set 3: Suzanne Teng Topanga Dreams 06:24 Suzanne Teng Lhasa Love 04:06 Suzanne Teng Lotus 02:35 Set 4: Sherry Finzer Secret of the Andes 04:22 Sherry Finzer A Walk Through Quiet 03:55 Sherry Finzer Healing Hands 04:08 Set 5: Francesca Gramegna True 02:55 Francesca Gramegna The Look Of Love 02:46 Francesca Gramegna Quanno Chiove 02:45 Francesca Gramegna L'Appuntamento 03:43 Francesca Gramegna Mas Que Nada 02:48 Set 6: Merry Ellen Kirk The Falling Sparrow 03:51 Adina Spire Te Deum 08:39 Michelle Qureshi Days So Long 02:53 Michelle Qureshi Open Window 02:48 Michelle Qureshi Slipped Away 03:06 Skaly Back to London 04:20 Skaly Snow for the First Time 03:02 Set 7: Borders Edge Music The Electric Monk (Bernhard Beibl, Kuutana) 09:46 Borders Edge Music Sorcerer's Apprentice (Daniel S Wolf, Kuutana) 07:17 Borders Edge Music Glimmer of Hope (Midnight Airship) 08:44 Borders Edge Music The Island (Sequential Dreams) 11:33 Borders Edge Music A Beautiful Day on New Earth (Kuutana) 04:32 Borders Edge Music Na Pali Sunset (Kuutana) 07:46 Francesca Gramegna SESTETTO - Medley Samba 02:45 Francesca Gramegna SESTETTO - Rock in Jazz 08:26 Francesca Gramegna QUINTETTO - Disco Revival 05:53 Set 8: Dana Cunningham Leap of Faith 06:12 Dana Cunningham Flowers in the Dark 05:11 Dana Cunningham Angels at Shady Grove 02:50 This will complete the program, sorry for the trouble and we'll do better next time!
Personal Troopers! We've already done the Huckebein, but that friend isn't the OG. The Gespenst here, piloted by our friend Gilliam Jaeger, is how it started. And how it's going? Well, that's next episode. You can find a video version of this podcast for free on Scanline Media's Patreon! If you want to find us on Twitter, Dylan is @lowpolyrobot and Six is @sixdettmar. Our opening theme is the Hangar Theme from Gundam Breaker 3, and our ending theme for this episode is Hero Chronicle (Ext.) from SRW OGs. Our podcast art is a fantastic piece of work from Twitter artist @fenfelt. Want to see a list of every unit we've covered from every episode, including variants and tangents? It's right here. Units discussed: PTX-01/PTX-001 Gespenst PTX-001RV Gespenst Type-RV PTX-002 Gespenst Mk-II PTX-007-02A Gespenst Mk-II Type-SA PTX-007-02AC Gespenst Mk-II Type-SA/Kai RPT-007 Mass-Production Gespenst Mk-II RPT-007TT Mass-Production Gespenst Mk-II Type-TT RPT-007K Mass-Production Gespenst Mk-II Kai RPT-007K Mass-Production Gespenst Mk-II Kai Type C RPT-007K Mass-Production Gespenst Mk-II Kai Type G PTX-002C Gespenst Haken RPT-007ET “Gesterben” Mass Produced Gespenst MK-II "Sterben" RPT-007ET-01C Gesterben Kai
Dans ce numéro hors-série, Jean-Luc Vandebroek, directeur financier de Hyloris vient faire le point sur l'actualité de la société biopharmaceutique belge, créée en 2012, qui optimise les traitements existants pour répondre à des besoins médicaux non adressés.Il évoque notamment le fait que la FDA vient d'accorder la qualification de médicament orphelin au PTX-252 pour le traitement de la Leucémie Myéloïde Aiguë (LMA), l'approbation de Maxigesic IV aux Etats-Unis.Il détaille également la stratégie d'élargissement du portefeuille et de partenariats d'Hyloris.
This audio is brought to you by Endress and Hauser, a leading supplier of products, solutions and services for industrial process measurement and automation. South African developers of mature green hydrogen or derivatives projects are potentially eligible for non-refundable grant funding being extended under Germany's €270-million Power-to-X (PtX) Development Fund, set up to close "bankability gaps" standing in the way of implementing industrial-scale projects in seven eligible developing countries. Funding for the platform, which was established in 2023, is being made available from the German Ministry for Economic Cooperation and Development and the fund's first call for expressions of interest (EoI) is open for projects in Brazil, Egypt, Georgia, India, Kenya, Morocco and South Africa. German development bank KfW has appointed KGAL Investment Management to manage the fund and the EoI has a project-submission deadline of 12:00 on March 1. KfW's Stefan Hediger tells Engineering News that the PtX Development Fund is part of a portfolio of instruments available for projects in developing countries and beneficiaries are not precluded from accessing other concessional and grant funding schemes being made available by Germany, including those funding commitments made in support of South Africa's Just Energy Transition Partnership Investment Plan (JET-IP). KfW has already concluded a €23-million grant funding agreement with the Industrial Development Corporation to support early-stage "catalytic" green hydrogen projects, and some South African project developers are also aiming to access concessional loans under the JET-IP, as well as the subsidised long-term purchase agreements being extended under the H2Global framework. The PtX Development Fund's niche, however, is to support advanced projects that require grant funding to close any residual gaps preventing the project from advancing to financial close. PtX Development Fund head Thomas Engelmann, who is also head of energy transition at KGAL, tells Engineering News that up to €30-million could be dispersed to individual projects should these meet the scheme's technical, environmental and social eligibility criteria. The fund is particularly keen to support industrial-scale projects with a total investment cost of over €100-million, and which are geared towards supplying sectors where the usage of hydrogen is hard to avoid. These could include products developed to use green hydrogen - produced using renewable electricity in an electrolyser to split water into hydrogen and oxygen - as a feedstock in the manufacture of green ammonia, green methanol, green synthetic fuels, and green hydrogen-based chemicals. The platform, Engelmann says, can be used to finance any part of the project's PtX value chain, from renewable energy generation and electrolysis, through to hydrogen compression, storage and transportation, as well as the distribution infrastructure. He expects the full €270-million to be dispersed over two to three bidding rounds to between eight and ten projects and reports that significant interest has already been shown by project developers in the various eligible countries since the launch of the EoI in December. Once a project is submitted, the PtX Development Fund will evaluate the project against the scheme's eligibility and exclusion criteria before selecting preferred projects to support. The planned investment horizon for the PtX Development Fund is between 2024 and 2027. Hediger is confident that there are projects in South Africa at a suitable level of maturity to qualify for the grant and reports that every effort is being made to market the opportunity to potential participants, with a webinar scheduled for February 13. KfW's Kelly Slaffa highlights that Germany's promotion of Green Hydrogen not only focusses on the development of the nascent industry in South Africa but importantly the promotion of skills transfer, development and job creation.
This audio is brought to you by Endress and Hauser, a leading supplier of products, solutions and services for industrial process measurement and automation. South African developers of mature green hydrogen or derivatives projects are potentially eligible for non-refundable grant funding being extended under Germany's €270-million Power-to-X (PtX) Development Fund, set up to close "bankability gaps" standing in the way of implementing industrial-scale projects in seven eligible developing countries. Funding for the platform, which was established in 2023, is being made available from the German Ministry for Economic Cooperation and Development and the fund's first call for expressions of interest (EoI) is open for projects in Brazil, Egypt, Georgia, India, Kenya, Morocco and South Africa. German development bank KfW has appointed KGAL Investment Management to manage the fund and the EoI has a project-submission deadline of 12:00 on March 1. KfW's Stefan Hediger tells Engineering News that the PtX Development Fund is part of a portfolio of instruments available for projects in developing countries and beneficiaries are not precluded from accessing other concessional and grant funding schemes being made available by Germany, including those funding commitments made in support of South Africa's Just Energy Transition Partnership Investment Plan (JET-IP). KfW has already concluded a €23-million grant funding agreement with the Industrial Development Corporation to support early-stage "catalytic" green hydrogen projects, and some South African project developers are also aiming to access concessional loans under the JET-IP, as well as the subsidised long-term purchase agreements being extended under the H2Global framework. The PtX Development Fund's niche, however, is to support advanced projects that require grant funding to close any residual gaps preventing the project from advancing to financial close. PtX Development Fund head Thomas Engelmann, who is also head of energy transition at KGAL, tells Engineering News that up to €30-million could be dispersed to individual projects should these meet the scheme's technical, environmental and social eligibility criteria. The fund is particularly keen to support industrial-scale projects with a total investment cost of over €100-million, and which are geared towards supplying sectors where the usage of hydrogen is hard to avoid. These could include products developed to use green hydrogen - produced using renewable electricity in an electrolyser to split water into hydrogen and oxygen - as a feedstock in the manufacture of green ammonia, green methanol, green synthetic fuels, and green hydrogen-based chemicals. The platform, Engelmann says, can be used to finance any part of the project's PtX value chain, from renewable energy generation and electrolysis, through to hydrogen compression, storage and transportation, as well as the distribution infrastructure. He expects the full €270-million to be dispersed over two to three bidding rounds to between eight and ten projects and reports that significant interest has already been shown by project developers in the various eligible countries since the launch of the EoI in December. Once a project is submitted, the PtX Development Fund will evaluate the project against the scheme's eligibility and exclusion criteria before selecting preferred projects to support. The planned investment horizon for the PtX Development Fund is between 2024 and 2027. Hediger is confident that there are projects in South Africa at a suitable level of maturity to qualify for the grant and reports that every effort is being made to market the opportunity to potential participants, with a webinar scheduled for February 13. KfW's Kelly Slaffa highlights that Germany's promotion of Green Hydrogen not only focusses on the development of the nascent industry in South Africa but importantly the promotion of skills transfer, development and job creation.
Überblick: Hausmitteilung: Anmerkung zur letzten Folge bezüglich der Gebäudeeffizienzrichtlinie, Blick auf die Preise: Strom und Gas stabil, CO2 gestiegen, Veröffentlichung des erneuerbaren Energieanteils an der Gesamtenergieproduktion im Jahr 2023 von BDEW erfolgt, Endbericht der Plattform Klimaneutrales Stromsystem (PKNS) nach beendeter Plenumssitzung erwartet, Einigung über Strommarktreform auf europäischer Ebene erfolgt, Erhöhung des nationalen CO2-Preises vom Bundestag beschlossen, Beteiligung Deutschlands mit 350 Mio. Euro an der Auktion der EHB beschlossen, Pilotprojekt in Großbritannien zum Heizen mit Wasserstoff gestoppt, Anlagenkosten in China veröffentlicht, Personalie der Woche: Andreas Zeiselmair, Lesetipps: Deutsches Klima-Konsortium (2023): Was wir heute übers Klima wissen - Basisfakten zum Klimawandel, die in der Wissenschaft unumstritten sind GIZ (2023): Explaining the new EU Carbon Border Adjustment Mechanism (CBAM) - Implications for PtX imports to the EU Internal Revenue Service (IRS), Treasury (2023): Section 45V Credit for Production of Clean Hydrogen; Section 48(a)(15) Election To Treat Clean Hydrogen Production Facilities as Energy Property Literatur: bdew (2023): Erneuerbare Energien deckten 2023 erstmals mehr als die Hälfte des Stromverbrauchs Bundesministerium der Finanzen (2023): Klima- und Transformationsfonds: Gezielt und technologieoffen in die Transformation unseres Landes investieren Bundesministerium für Wirtschaft und Klimaschutz (2023): EU-Kommission und Bundeswirtschaft- und Klimaschutzministerium kündigen heute Meilenstein bei der Förderung nachhaltiger und sauberer Energielösungen für den Wasserstoffhochlauf an Department for Energy Security & Net Zero (2023): Hydrogen Strategy Delivery Update Die Bundesregierung (2023): CO2-Preis steigt auf 45 Euro pro Tonne Frankfurter Allgemeine (2023): Die Regierung will den CO2-Preis deutlich anheben Hydrogeninsight (2023): Auction results reveal that Chinese hydrogen electrolysers are two to five times cheaper to buy than Western machines Kontakt: Twitter (redispatch_pod), LinkedIn (Redispatch)
Vært: Henrik Heide Medvirkende: Laurids Hovgaard, Frederik Marcher Hansen og Bjørn Godske Klip: Søren Rask Petersen I denne uges Transformator skal det først handle om Sig Sauer P320, som er navnet på politiets nye tjenestepistol. Den har fået heftig kritik i USA, for den er uden fysisk sikring, der forhindrer den i at affyre i utide. I USA har medier kortlagt 100 tilfælde, hvor folk hævder, at deres P320-pistoler blev affyret, selvom de ikke havde trykket på aftrækkeren. Det snurrer ikke ligefrem for de danske havvindprojekter i år. Havmølleparkerne Vesterhav Syd og Nord er med deres samlede effekt på 344 MW de eneste, der bliver koblet på elnettet i år. I april underskrev Danmark og ni andre EU-lande ellers en aftale om ca. 120 GW havvind i Nordsøen i 2030. Flere store vindmølleprojekter er blevet droppet i den seneste tid, f.eks. Aflandshage Havvindmøllepark på 300 MW i Øresund og et havvindprojekt på 100 MW ud for Bornholm, og det betyder, at der mangler grøn strøm til storskalaproduktionen af bæredygtige e-brændstoffer. Det rammer bl.a. Ørsted, som overvejer at droppe power-to-x-projektet Green Fuels for Denmark ved Avedøreværket syd for København. Det skyldes både stigende omkostninger og manglen på ny, grøn strøm i Østdanmark. Udmeldingen fik 1. november Ørsteds aktie til at falde med 20 procent. Også den danske brintbranche er afhængig af grøn strøm, men her planlægger man i et noget længere perspektiv. Fokus er på at komme først som leverandør til de store forbrugscentre især i Tyskland. Det skal ske via et helt nyt net af brintkabler mellem de europæiske lande. Links Politiet køber kontroversiel pistol uden sikring - slagstiften er altid spændt Grøn omstilling bremser op: ‘Kriselignende tilstand i vindsektoren lige nu' Ørsteds krise stikker dybt: Nu er et af Danmarks største PtX-projekter 'udfordret' Industrieventyret, der kan blive en gamechanger: Spillet om brint er i gang
Insider Financial recaps today's stock market action and previews our trading plan for tomorrow. To get our FREE reports and eBook, go to: https://signup.insiderfinancial.com/ To get FREE stocks and trade from 4 am to 8 pm on WeBull, visit: https://a.webull.com/i/ insiderfinancial. This video covers SPY, QQQ, DIA, IWM, TLT, GLD, USO, BTC, PRZO, HUBC, MTEK, VCNX, ASAN, LAAC, LAC, PLTR, GD, LMT, PTX, NOC, NEE. AI and Defense Stocks Are In Play Right Now! Disclosure: Insider Financial has not been compensated for this video. Insider Financial is not an investment advisor; this video does not provide investment advice. Always do your research, make your own investment decisions, or consult with your nearest financial advisor. This video is not a solicitation or recommendation to buy, sell, or hold securities. This video is our opinion, is meant for informational and educational purposes only, and does not provide investment advice. Past performance is not indicative of future performance. For more information, please read our full disclaimer: https://insiderfinancial.com/disclaimer/ S&p 500, Dow, Nasdaq, SPY ETF, QQQ ETF, DIA ETF, TLT ETF, GLD ETF, USO ETF, Gold, Oil, Bonds, Stocks, pot stocks, weed stocks, cannabis stocks, takeover stocks, quantum computing stocks, Spac stocks, AI stocks, Bitcoin stocks, crypto stocks, short squeeze, short squeeze stocks, low float, low float stocks, lithium stocks, ev stocks, small caps, trading, otc stocks, otc stocks list, penny stocks, penny stocks list, NASDAQ penny stocks, NYSE stocks, NYSE penny stocks, biotech stocks, PRZO stock, HUBC stock, MTEK stock, VCNX stock, ASAN stock, Asana stock, LAAC stock, LAC stock, PLTR stock, Palantir stock, GD stock, defense stocks, military stocks, LMT stock, Lockheed Martin stock, General Dynamics stock, RTX stock, Raytheon stock, NOC stock, NEE stock #smallcapstocks #pennystocks #aistocks
Chegou mais um Check-up Semanal, com as novidades da medicina e da saúde que você precisa saber para começar a semana atualizado. Confira os temas do check-up de hoje: quanto tempo leva para engravidar após cirurgia de endometriose; PTX: drenagem tubular vs aspiração a vácuo; antibioticoterapia de período curto para crianças com ITU; sódio urinário e acetazolamida na congestão da IC e diretriz no abortamento recorrente. Ouça agora! Confira esse e outros posts no Portal PEBMED e siga nossas redes sociais! Facebook Instagram Linkedin Twitter
We are now launching our dedicated new YouTube and Twitter! Any help in amplifying our podcast would be greatly appreciated, and of course, tell your friends! Notable followon discussions collected on Twitter, Reddit, Reddit, Reddit, HN, and HN. Please don't obsess too much over the GPT4 discussion as it is mostly rumor; we spent much more time on tinybox/tinygrad on which George is the foremost authority!We are excited to share the world's first interview with George Hotz on the tiny corp!If you don't know George, he was the first person to unlock the iPhone, jailbreak the PS3, went on to start Comma.ai, and briefly “interned” at the Elon Musk-run Twitter. Tinycorp is the company behind the deep learning framework tinygrad, as well as the recently announced tinybox, a new $15,000 “luxury AI computer” aimed at local model training and inference, aka your “personal compute cluster”:* 738 FP16 TFLOPS* 144 GB GPU RAM* 5.76 TB/s RAM bandwidth* 30 GB/s model load bandwidth (big llama loads in around 4 seconds)* AMD EPYC CPU* 1600W (one 120V outlet)* Runs 65B FP16 LLaMA out of the box (using tinygrad, subject to software development risks)(In the episode, we also talked about the future of the tinybox as the intelligence center of every home that will help run models, at-home robots, and more. Make sure to check the timestamps
New technology is regularly being developed and enhanced to improve power delivery and incorporate more renewable energy into systems. ABB Energy Industries is among the companies investing large sums of money in research and development (R&D) programs to make future power systems better. Among its current projects are subsea power distribution and conversion concepts, which could benefit the offshore wind industry, and a Power-to-Ammonia pilot project. “We have a lot of experience—over 20 years—with this subsea equipment,” Asmund Maland, head of subsea and offshore power at ABB Energy Industries, said as a guest on The POWER Podcast. “Our intention is to put on the seabed what we call the ‘services substation and collector systems,'” he explained. Maland said the subsea equipment could replace or act as an alternative to a floating substation, which he expects will be more needed as the offshore wind industry moves to deeper waters. ABB has already tested these systems for the oil and gas (O&G) industry with great early success. Nearly a decade ago, the company initiated a $100 million Joint Industrial Project with Equinor (formerly Statoil), Total, and Chevron with support from the Research Council of Norway. As part of that project, ABB completed the development of an electrification system for transmission, distribution, and conversion of power, to subsea pumps and gas compressors, at a peak capacity of 100 MW, to water depths up to 3,000 meters, with transmission distances up to 600 kilometers, and with little or no maintenance for up to a lifetime of 30 years. “If you replace a floating substation with something on the subsea, you will reduce to one-fifth of the steel. So, by that, there is also then potential capex [capital expenditure] savings of maybe over 30%, and also, the opex [operating expense] savings of the year will also be quite good,” said Maland. ABB expects to be ready to take orders for subsea offshore systems by the end of 2024. On the podcast, Tom Zøllner, head of ABB Energy Industries for Denmark, talked about another innovative project ABB is involved in, which the company calls “the world's first dynamic green Power-to-Ammonia plant.” ABB is working alongside Danish companies Skovgaard Energy, Vestas, and Haldor Topsoe to demonstrate Power-to-X (PtX) technology in Lemvig, northwest Denmark. The project is also being supported by the Danish government's Energy Technology Development and Demonstration Programme, which provided about $12 million in assistance. “The reason behind the project is that in Denmark we have for some time been one of the lead countries when it comes to green energy, and it has been more and more clear that we need to figure out how to store all this additional energy that we may not be able to use all the time. Unfortunately, batteries are not strong enough, and therefore, we need to look into alternatives, and Power-to-X has become one of the solutions that we have been looking into for some time,” Zøllner said. The demonstration facility—scheduled to start operating in 2024—will be powered by renewables from 12 MW of existing wind turbines and 50 MW of new solar panels. ABB is responsible for electrical integration and advanced process control of the full Power-to-Ammonia plant operating in highly dynamic mode. The 10-MW plant is expected to operate at full capacity when excess wind and solar power are available, but will gear production down when neither renewable energy source is present, making it adaptable to fluctuations in energy supply and different from other types of PtX plants, which are directly connected to the grid. The pilot plant will produce about 5,000 tons of ammonia per year. While the project is small in the grand scheme of things, Zøllner said it will showcase the technology and should be scalable in the future.
Prescient Therapeutics (ASX: PTX) managing director and chief executive officer Steven Yatomi-Clarke joins Small Caps to discuss the company's development activities and plans for its novel targeted anti-cancer therapies. The company recently locked-in US Food and Drug Administration orphan drug status for lead candidate PTX-100 in treating T-cell lymphomas where clinical trials are showing promising results. Prescient has also topped up its cash reserves with $11.3 million raised to fund further development across its portfolio. Articles:https://smallcaps.com.au/prescient-therapeutics-ptx-100-promising-results-clinical-t-cell-lymphoma-trial/https://smallcaps.com.au/prescient-therapeutics-fda-orphan-drug-status-ptx-100-treat-t-cell-lymphomas/ For more information on Prescient Therapeutics: https://smallcaps.com.au/stocks/PTX/See omnystudio.com/listener for privacy information.
Møde nr. 28 i salen 1) Spørgsmål om fremme af forespørgsel nr. F 3: Forespørgsel til indenrigs- og sundhedsministeren om børn og unges brug af opioider. Af Mette Thiesen (DF) m.fl. (Anmeldelse 21.02.2023. Omtrykt). 2) 3. behandling af lovforslag nr. L 12: Forslag til lov om Fonden for Plantebaserede Fødevarer. Af ministeren for fødevarer, landbrug og fiskeri (Jacob Jensen). (Fremsættelse 18.01.2023. 1. behandling 31.01.2023. Betænkning 08.02.2023. 2. behandling 21.02.2023. Lovforslaget optrykt efter 2. behandling). 3) 2. behandling af lovforslag nr. L 13: Forslag til lov om konsekvenser ved afskaffelsen af store bededag som helligdag. Af beskæftigelsesministeren (Ane Halsboe-Jørgensen). (Fremsættelse 24.01.2023. 1. behandling 02.02.2023. Betænkning 21.02.2023). 4) 1. behandling af lovforslag nr. L 38: Forslag til lov om ændring af lov om Det Centrale Personregister. (Kommunernes kontrol med bopælsregistreringen i CPR). Af indenrigs- og sundhedsministeren (Sophie Løhde). (Fremsættelse 08.02.2023). 5) 1. behandling af lovforslag nr. L 39: Forslag til lov om ændring af lov om Det Centrale Personregister, lov om folketingsvalg i Grønland og lov om valg til Folketinget. (Bopælsregistrering i Danmark og Grønland af personer, der af Grønlands Selvstyre eller den danske stat er beordret til tjeneste uden for riget, optagelse på folketingsvalglisterne i Danmark og Grønland m.v.). Af indenrigs- og sundhedsministeren (Sophie Løhde). (Fremsættelse 08.02.2023). 6) 1. behandling af lovforslag nr. L 37: Forslag til lov om ændring af lov om elforsyning og lov om afgift af elektricitet. (Implementering af forskellige aftaler om grøn omstilling, herunder dele af PtX-aftalen af 15. marts 2021). Af klima-, energi- og forsyningsministeren (Lars Aagaard). (Fremsættelse 08.02.2023). 7) 1. behandling af beslutningsforslag nr. B 7: Forslag til folketingsbeslutning om en ambitiøs strategi for energieffektiviseringer og energibesparelser frem mod 2030. Af Søren Egge Rasmussen (EL) m.fl. (Fremsættelse 13.12.2022). 8) 1. behandling af lovforslag nr. L 31: Forslag til lov om ændring af lov om ligebehandling af mænd og kvinder med hensyn til beskæftigelse m.v., lov om arbejdsmiljø og lov om erhvervsuddannelser. (Udmøntning af »Trepartsaftale om initiativer til at modgå seksuel chikane på arbejdspladser« og forlængelse af hjemmel til smileyordningen). Af beskæftigelsesministeren (Ane Halsboe-Jørgensen). (Fremsættelse 01.02.2023). 9) 1. behandling af beslutningsforslag nr. B 11: Forslag til folketingsbeslutning om 26 ugers udvidet barsel til tvillinge- og flerlingefamilier (borgerforslag). Af Leif Lahn Jensen (S), Lars Christian Lilleholt (V), Henrik Frandsen (M), Karina Lorentzen Dehnhardt (SF), Peter Skaarup (DD), Ole Birk Olesen (LA), Mai Mercado (KF), Peder Hvelplund (EL), Martin Lidegaard (RV), Helene Liliendahl Brydensholt (ALT), Peter Seier Christensen (NB), Peter Kofod (DF) og Aaja Chemnitz (IA) . (Fremsættelse 05.01.2023). 10) 1. behandling af lovforslag nr. L 35: Forslag til lov om ændring af lov om udlejning af fast ejendom til ferie- og fritidsformål m.v. og campering m.v. (Forsøgsordning for udvidet vintercampering). Af ministeren for landdistrikter (Louise Schack Elholm). (Fremsættelse 08.02.2023). 11) 1. behandling af lovforslag nr. L 36: Forslag til lov om ændring af lov om planlægning, lov om Planklagenævnet og lov om Miljø- og Fødevareklagenævnet. (Fremme af vedvarende energi i den fysiske planlægning og effektivisering af sagsbehandling i Planklagenævnet og Miljø- og Fødevareklagenævnet). Af ministeren for landdistrikter (Louise Schack Elholm). (Fremsættelse 08.02.2023).
Møde nr. 28 i salen 1) Spørgsmål om fremme af forespørgsel nr. F 3: Forespørgsel til indenrigs- og sundhedsministeren om børn og unges brug af opioider. Af Mette Thiesen (DF) m.fl. (Anmeldelse 21.02.2023. Omtrykt). 2) 3. behandling af lovforslag nr. L 12: Forslag til lov om Fonden for Plantebaserede Fødevarer. Af ministeren for fødevarer, landbrug og fiskeri (Jacob Jensen). (Fremsættelse 18.01.2023. 1. behandling 31.01.2023. Betænkning 08.02.2023. 2. behandling 21.02.2023. Lovforslaget optrykt efter 2. behandling). 3) 2. behandling af lovforslag nr. L 13: Forslag til lov om konsekvenser ved afskaffelsen af store bededag som helligdag. Af beskæftigelsesministeren (Ane Halsboe-Jørgensen). (Fremsættelse 24.01.2023. 1. behandling 02.02.2023. Betænkning 21.02.2023). 4) 1. behandling af lovforslag nr. L 38: Forslag til lov om ændring af lov om Det Centrale Personregister. (Kommunernes kontrol med bopælsregistreringen i CPR). Af indenrigs- og sundhedsministeren (Sophie Løhde). (Fremsættelse 08.02.2023). 5) 1. behandling af lovforslag nr. L 39: Forslag til lov om ændring af lov om Det Centrale Personregister, lov om folketingsvalg i Grønland og lov om valg til Folketinget. (Bopælsregistrering i Danmark og Grønland af personer, der af Grønlands Selvstyre eller den danske stat er beordret til tjeneste uden for riget, optagelse på folketingsvalglisterne i Danmark og Grønland m.v.). Af indenrigs- og sundhedsministeren (Sophie Løhde). (Fremsættelse 08.02.2023). 6) 1. behandling af lovforslag nr. L 37: Forslag til lov om ændring af lov om elforsyning og lov om afgift af elektricitet. (Implementering af forskellige aftaler om grøn omstilling, herunder dele af PtX-aftalen af 15. marts 2021). Af klima-, energi- og forsyningsministeren (Lars Aagaard). (Fremsættelse 08.02.2023). 7) 1. behandling af beslutningsforslag nr. B 7: Forslag til folketingsbeslutning om en ambitiøs strategi for energieffektiviseringer og energibesparelser frem mod 2030. Af Søren Egge Rasmussen (EL) m.fl. (Fremsættelse 13.12.2022). 8) 1. behandling af lovforslag nr. L 31: Forslag til lov om ændring af lov om ligebehandling af mænd og kvinder med hensyn til beskæftigelse m.v., lov om arbejdsmiljø og lov om erhvervsuddannelser. (Udmøntning af »Trepartsaftale om initiativer til at modgå seksuel chikane på arbejdspladser« og forlængelse af hjemmel til smileyordningen). Af beskæftigelsesministeren (Ane Halsboe-Jørgensen). (Fremsættelse 01.02.2023). 9) 1. behandling af beslutningsforslag nr. B 11: Forslag til folketingsbeslutning om 26 ugers udvidet barsel til tvillinge- og flerlingefamilier (borgerforslag). Af Leif Lahn Jensen (S), Lars Christian Lilleholt (V), Henrik Frandsen (M), Karina Lorentzen Dehnhardt (SF), Peter Skaarup (DD), Ole Birk Olesen (LA), Mai Mercado (KF), Peder Hvelplund (EL), Martin Lidegaard (RV), Helene Liliendahl Brydensholt (ALT), Peter Seier Christensen (NB), Peter Kofod (DF) og Aaja Chemnitz (IA) . (Fremsættelse 05.01.2023). 10) 1. behandling af lovforslag nr. L 35: Forslag til lov om ændring af lov om udlejning af fast ejendom til ferie- og fritidsformål m.v. og campering m.v. (Forsøgsordning for udvidet vintercampering). Af ministeren for landdistrikter (Louise Schack Elholm). (Fremsættelse 08.02.2023). 11) 1. behandling af lovforslag nr. L 36: Forslag til lov om ændring af lov om planlægning, lov om Planklagenævnet og lov om Miljø- og Fødevareklagenævnet. (Fremme af vedvarende energi i den fysiske planlægning og effektivisering af sagsbehandling i Planklagenævnet og Miljø- og Fødevareklagenævnet). Af ministeren for landdistrikter (Louise Schack Elholm). (Fremsættelse 08.02.2023).
Link to bioRxiv paper: http://biorxiv.org/cgi/content/short/2023.02.12.528175v1?rss=1 Authors: Kume, M., Ahmad, A., DeFea, K. A., Vagner, J., Dussor, G., Boitano, S., Price, T. J. Abstract: Background and Purpose: Chemotherapy-Induced Peripheral Neuropathy (CIPN) is a common, dose-limiting side effect of cancer therapy. Protease-activated receptor 2 (PAR2) is implicated in a variety of pathologies, including CIPN. In this study, we demonstrate the role of PAR2 expressed in sensory neurons in a paclitaxel (PTX)-induced model of CIPN in mice. Experimental Approach: CIPN was induced in both PAR2 knockout/WT mice and mice with PAR2 ablated in sensory neurons via the intraperitoneal injection of paclitaxel. In vivo behavioral studies were done in mice using von Frey filaments and the Mouse Grimace Scale. We then examined immunohistochemical staining of dorsal root ganglion (DRG) and hind paw skin samples from CIPN mice to measure satellite cell gliosis and intra-epidermal nerve fiber (IENF) density. Pharmacological reversal of CIPN pain was tested with the PAR2 antagonist C781 Key Results: Mechanical allodynia caused by paclitaxel treatment was alleviated in PAR2 knockout mice of both sexes. In the PAR2 sensory neuronal conditional knockout (cKO) mice, both mechanical allodynia and facial grimacing were attenuated in mice of both sexes. In the dorsal root ganglion of the paclitaxel-treated PAR2 cKO mice, satellite glial cell activation was reduced compared to control mice. IENF density analysis of the skin showed that the paclitaxel-treated control mice have a reduction in nerve fiber density while the PAR2 cKO mice had a comparable skin innervation as the vehicle-treated animals. Similar results were seen with satellite cell gliosis in the DRG where gliosis induced by PTX was absent in PAR cKO mice. Finally, C781 was able to transiently reverse established PTX-evoked mechanical allodynia. Conclusions and Implications: Our work demonstrates that PAR2 expressed in sensory neurons plays a key role in paclitaxel-induced mechanical allodynia, spontaneous pain and signs of neuropathy, suggesting PAR2 as a possible therapeutic target in multiple aspects of paclitaxel CIPN. Copy rights belong to original authors. Visit the link for more info Podcast created by Paper Player, LLC
We continue our conversation about hydrogen with Michillay Brown, corporate relations principal at Anglo American, Nuria Hartmann, manager, strategy and business consulting at HINICIO, and Ivana Jemelkova, senior managing director at FTI Consulting, and our podcast hosts Sarah Devine and Rebecca Abou-Chedid. What is Power-to-X (PtX) and what are the main challenges for PtX project development? What is the current state of hydrogen market development in South Africa and Latin America? Are there collaboration opportunities between the two regions and importing countries?We explore this and more in part two of this two-part episode on hydrogen. We discuss current opportunities for hydrogen development in emerging markets, including sources of investment, and the future outlook for the global hydrogen economy.
What's that on the horizon? It's not an Armored Trooper! It's not a Gundam! It's a PERSONAL TROOPER! ...and kinda just a Gundam. Our first ever Super Robot Wars original design we've covered is the Huckebein, aka a Katoki Gundam with the serial numbers filed off. Not only that, it has a Gundam-like family tree of lots of robots, so we have plenty to talk about! against my better judgment, here is a link to "chicken cyclone" If you want to find us on Twitter, Dylan is @lowpolyrobot and Six is @sixdettmar. Our opening theme is the Hangar Theme from Gundam Breaker 3, and our ending theme for this episode is Divine Beast by M.A.R.Y. 4 TUNES from Super Robot Wars 30. Our podcast art is a fantastic piece of work from Twitter artist @fenfelt. Want to see a list of every unit we've covered from every episode, including variants and tangents? It's right here. Units discussed: PTX-08 Huckebein RTX-009 Huckebein PTX-005 Wildschwein RPT-005 Mass-Production Wildschwein RTX-008LC/RTX-009EX Huckebein EX RTX-010 Huckebein Mk-II RTX-010-02T Huckebein Mk-II Trombe RTX-013/RPT-010 Mass-Production Huckebein Mk-II Bergelmir Sniper PT RPT-10M3C-03 Pfeil III RTX-011 Huckebein Mk-III RTX-011RT Huckebein Mk-III Trombe RTX-011-AMB Huckebein Boxer AM Boxer RTX-011-AMG Huckebein Gunner AM Gunner PTX-G Guarbein Mk-III PTX-GT Guarbein Mk-III Trombe PTX-GAMG Guarbein Gunner RTX-009EX/PTX-EX Exbein PTX-EXAMB Exbein Boxer PTX-EXAMG Exbein Gunner PTX-EXH Ash PTX-DEX Exexbein PT-XXX Huckebein 30 PT-XXXth Huckebein 30th Galilnagant
Link to bioRxiv paper: http://biorxiv.org/cgi/content/short/2022.10.19.512871v1?rss=1 Authors: Huh, Y., Luo, X., Liu, D., Jiang, C., Ji, R.-R. Abstract: Chemotherapy-induced peripheral neuropathy (CIPN) is the de facto clinical side effect that limits the administration of anti-cancer treatments. Recently, we reported that intrathecally injected bone marrow stromal cells (BMSCs) reduced nerve trauma-induced neuropathic pain in male mice via TGF-{beta}1 signaling. In this study, we examined sex-dependent pain relief mediated by intrathecally delivered BMSCs and TGF-{beta}1 in paclitaxel (PTX)-induced CIPN. BMSCs were prepared from primary cultures of male or female mice separately. A single intrathecal injection of BMSCs, prepared from male donors, completely prevented the development of PTX-evoked mechanical allodynia in male mice. However, female mice showed no analgesic response to either male or female BMSCs. Additionally, male mice did not demonstrate an analgesic response to BMSCs from female donors. Intrathecal injection of TGF-{beta}1 neutralizing antibody reversed the analgesic action of BMSCs. Interestingly, spinal administration of TGF-{beta}1 reduced mechanical allodynia in male mice but not in female mice. Ex vivo patch-clamp recordings in spinal cord slices revealed that TGF-{beta}1 inhibited PTX-induced synaptic plasticity, i.e. increase in spontaneous excitatory synaptic currents (sEPsCs), in spinal cord neurons from male mice only. Intrathecal TGF-{beta}1 increased the paw withdrawal threshold in von Frey testing in naive mice of males but not females, and the antinociceptive effect of TGF-{beta}1 in males was blocked by orchiectomy-induced androgen deficiency. Together, these findings reveal sex dimorphism in BMSC control of mechanical pain through spinal TGF-{beta}1 signaling. Copy rights belong to original authors. Visit the link for more info Podcast created by Paper Player, LLC
02:17 Labiotech.eu news04:59 TikoMed09:20 Pleco Therapeutics25:45 Cullinan Oncology/World Cancer Research Day44:15 JLLThis week's podcast has three guests. In honor of World Cancer Research Day on September 24, we have an overview of cancer research with Nadim Ahmed, CEO of Cullinan Oncology; a chat with Ivo Timmermans, CEO of Pleco Therapeutics; and talk with Anders Kristensson, CEO of TikoMed.We also have our weekly chat with global commercial real estate services company JLL, with Travis McCready. This week's podcast is sponsored by Single Use Support, the end-to-end process solution provider for fluid management.World Cancer Research Day: Support research to prevent cancer and catch it earlyFor seven consecutive years, the international research community is marking World Cancer Research Day (WCRD) on September 24, a global movement that seeks to raise awareness of the importance of cancer research to increase survival, facilitate access to scientific advances worldwide and reduce the global burden of cancer. This year, experts in the field of oncology and cancer researchers will focus on cancer health disparities, particularly in the areas of prevention and early detection research and care. The motto this year is Support research to prevent cancer and catch it early.Cullinan OncologyTo talk about the current state of cancer research, we spoke with Nadim Ahmed, CEO of Cullinan Oncology.Cullinan Oncology is a biopharmaceutical company dedicated to creating new standards of care for patients with cancer. It finds the most promising clinic-ready cancer therapies through its own discovery efforts and engagement with academic and industry partners. Pleco Therapeutics raises €17.3M to develop AML productPleco Therapeutics BV, a specialty biopharma company in the Netherlands developing novel treatments designed to detoxify the cancer micro-environment has raised total funds of $17.2 million in series A financing. The funds will be used to complete development of, and to commercialize, the company's novel lead Plecoid product, PTX-061, to improve the effectiveness of chemotherapy in patients with acute myeloid leukaemia (AML).Pleco's technology provides a platform for the development of a pipeline of therapies. In addition to PTX-061 for AML, the current pipeline includes additional candidates in preclinical testing for the treatment of other rare diseases such as SCLC.Research shows TikoMed's ILB can treat neurodegenerative diseases including ALSPeer-review research published in Frontiers in Pharmacology supports the broad spectrum mechanism of action of Swedish biopharma company TikoMed's ILB neuroprotective drug platform. In multiple preclinical and clinical studies across a variety of neuroinflammation-driven diseases, the low molecular weight dextran sulfate compound both mobilized and modulated naturally occurring tissue repair mechanisms and restored cellular homeostasis and function by releasing heparin-binding growth factors. SponsorInterested in sponsoring one or more episodes of the podcast? Learn more here!Leave a review on Apple podcastsReviews are hugely important because they help new people discover this podcast. If you enjoyed listening to this episode, we would love to hear your feedback!Connect with uslabiotech.euSubscribe to our newsletter
Prescient Therapeutics (ASX: PTX) managing director and chief executive officer Steven Yatomi-Clarke joins Small Caps to discuss the company's plans for its innovative cancer therapies PTX-100 and PTX-200. Prescient launched an $8 million capital raising last month to fund the progression of the two therapies towards first in-human clinical studies. The company is also advancing its next generation OmniCAR CAR-T platform for fighting cancer, which it says can do what conventional CAR-T cannot. Articles:https://smallcaps.com.au/prescient-therapeutics-enters-strategic-collaboration-renowned-cancer-centre-us/https://smallcaps.com.au/prescient-therapeutics-progress-innovative-pipeline-cancer-treatments-capital-raise/https://smallcaps.com.au/prescient-therapeutics-signs-deal-q-gen-omnicar-clinical-trials/ For more information on Prescient Therapeutics : https://smallcaps.com.au/stocks/PTX/ See omnystudio.com/listener for privacy information.
ASX 200 falls 45 points to 6606 (-0.7%) after a solid rally off lows. Resources took the big hit. Banks had a decent rally off early lows. Resources saw commodities flop and took the sector with it. BHP down 3.5%, FMG off 6.2% and RIO down 2.9%. Gold miners also fell, NCM down 2.8%, NST off 2.5%. Base metal stocks hit, IGO down 7.1%, POS off 2.4% and S32 falling 3.7%. Lithium stocks down but escaping somewhat, AKE down 1.4%, PLS off 2.9% and LYC off 0.7% in the REE space. Oil and gas stocks were flat as oil briefly fell below US$95 for Brent. Coal stocks eased back slightly, WHC down 2.3%, NHC off 1.7% and SMR dropping 1.6%. In the banks, the Big Bank Basket fell to $163.26 (-0.01%). CBA up 0.1% with ANZ under pressure over its MYOB business buy, down 1.3%. MQG fell 1.8% in sympathy with US banks. Insurers eased, QBE down 0.6%. Healthcare better led by CSL up 1.0%, RMD up 1.9%, COH up 1.7%. Industrials flat, WOW and COL higher but REA fell 1.2%, SEK down 2.7% and CAR off 4.3%.WES 0.9% better. Tech dominated by a good update from WTC up 3.4%, the All-Tech Index fell 0.8%. In corporate news, JIN fell 15.00% on a disappointing update. PDL saw FUM drop again and the stock fell 7.8%. PTX up 15.62% on news on orphan drug designation for PTX 100. Asian markets mixed, 10-year yields steady at 3.40%. Why not sign up for a free trial? Get access to expert insights and research and become a better investor.
Meet Zach! We met Zach in April and we're blown away by his creativity and positivity. He has a true passion for film, photography and history. We're excited to have him on the DeadCat team and we can't wait to see where the future takes him. Hear the full story on this week's episode of PTX a Podcast!
Meet Savannah. It was hard to fit so much story in one podcast! Savannah has an incredible story and we're willing to bet some of it will take you by surprise. Tune in on this weeks PTX a Podcast and help us wish Savannah Hubbard a happy birthday in the comments!!!
Welcome back! This week, we're doing things a little different. Our host, Broadway, is in the hot seat with good friend JoKyle Varner asking all the questions. With over 100 episodes on PTX, we thought it was time you hear from the man himself. Get to know our host and more about his family as well as DeadCat on this episode of PTX a Podcast! * This episode is sponsored by Cycle Works Paris- Bicycle Repair, Sales and Service. Thank you for making this episode possible!
Meet Austin. This week we're honored to introduce the owner and founder of Taste Catering of Paris. His story is really unique with a few twists and experiences along the way. What is PTX a Podcast? - A podcast all about Paris, Texas and the amazing stories that live here. - Some of our guests are born and raised here while others have graciously adopted it as home! - Know someone that should be on here? Send a nomination to info@deadcatmedia.com
Meet the Johnsons. We're honored to welcome Brittany and Wendell Johnson on PTX a Podcast. These two always bring the laughs and good vibes. They are true entrepreneurs and give their whole hearts to all they do. Here's a bit of their story with our host, Broadway!
Vært: Henrik Heide Medvirkende: Bjørn Godske, Andreas Lindqvist og Jens Ramskov I denne uges Transformator havde vi nær sagt ‘Hvad sagde vi?' For selvom det ikke er så klædeligt at være bagklog, er det svært at lade være, når det pludselig er en stor historie i medierne, at der ikke bliver produceret tilstrækkeligt med grøn strøm til at imødekomme det store behov, vi står overfor morgendagens elektrificerede samfund. For det har vi her i Teknologiens Mediehus gjort opmærksom på det sidste år. Bjørn Godske ridser problemerne op. To-fire kystubåde bør stå helt i toppen af Søværnets ønskeliste for militært isenkram, lyder det fra både borgerlige partier og forsvarskilder. Den danske ubådskapacitet blev udfaset i 2004, men Søværnet vil allerede kunne dykke igen om få år, hvis politikerne skriver kontrakt med den eneste oplagte leverandør. Den gamle definition af sekundet ved hjælp af cæsium-133 er ved at være forældet. Optiske atomure baseret på strontiumatomer, der har en karakteristisk frekvens omkring 429 THz, er nu blevet så pålidelige og almindelige, at man i standardiseringsorganisationer overvejer, om tiden er moden til at skifte definition. Links PtX-skåltalerne glemmer to problemer Politikere vil have ubåde tilbage: Militæranalytiker anbefaler tysk model Sekundet er snart modent til at få en ny definition Forskere måler tidsforskelle mellem toppen og bunden af en lille atomsky CPH:DOX: Into the ice CPH:DOX: Fire of love
Sağlıklı ve iyi yıllar dilerim! Bu yazımızda Travma ve Akut Bakım Cerrahisi Dergisi (Journal of Trauma and Acute Care Surgery)'nin Ocak 2022'de dumanı üzerinde yayınladığı makaleyi özetleyeceğiz. Orjinal haline buradan ulaşabilirsiniz. Bu çalışma mevcut algoritma ve tavsiyeler, mevcut yayınlanmış prospektif kohort, gözlemsel ve retrospektif çalışmalara ve Batı Travma Derneği (Western Trauma Association - WTA) üyelerinin uzman görüşüne dayanan ve önerilen; travmatik pnömotoraks (PTX) tedavisi için bir algoritmadır. Bu açıklamalı algoritma, kurumlardaki protokollerin geliştirilmesi için bir temel olarak veya klinisyenler için hızlı bir yatak başı referansı olarak hizmet etmek için hazırlanmıştır.1 Giriş Göğüs travmalarında en sık karşılaşılan yaralanmalar; pnömotoraks (PTX) , kot kırıkları, pulmoner kontüzyo ve hematorakstır. 2,3 Tarihsel olarak bakıldığında travmatik PTX tedavisinde göğüs tüpü uygulaması olmazsa olmaz bir yöntem idi. Zaman içinde görüntüleme yöntemlerinin gelişmesi ve bilgisayarlı tomografinin (BT) her yerde yaygın olarak kullanılmasının ardından PTX tespitindeki hassasiyet ile bu durum değişti ve cerrahlar arasında her PTX için tüp dekompresyonunun gerekli olup olmadığının sorgulamasına neden oldu. Zamanla hem PTX tanısında hem de tedavisi için kullanılan göğüs tüpünün boyutlarında önemli ölçüde azalma oldu. Bu algoritmanın hazırlanmasındaki amaç; göğüs tüpü gerektiren veya göğüs tüpünün ilave morbiditesinden kaçınarak güvenli bir şekilde gözlemlenebilen hastaları daha doğru bir şekilde seçmektir. Göğüs tüpleri %20'ye varan bir morbidite insidansı ile ilişkilendirilebilir ve bu nedenle kar-zarar değerlendirmesi yaparak, fayda görme olasılığı en yüksek olan hastalarda seçici olarak kullanılmalıdır. 4,5 Travmatik bir PTX'in yönetimi için Batı Travma Derneği (Western Trauma Association - WTA) algoritması.1 Radyolojik tanım olarak PTX parietal ve visseral plevra arasında röntgen veya BT taramasında izlenen bir açıklık (hava) olarak tanımlanır. Açık bir PTX, röntgende görülebilir, oysa gizli bir PTX röntgende görülmez, ancak BT taramasında veya göğüs ultrasonunda tanımlanır. 6 Ultrasonda öncelikle M modu paternleri ile plevral kayma kaybı primer olarak ; kuyruklu yıldız bulgusu, akciğer noktası vb ek bulgular ise sekonder olarak tanıyı destekler. Bu kılavuzda tanı yöntemleri arasında bir ayrım yapılmamıştır. M modunda bir pnömotoraksın ultrason görüntüsü.( Orjinal makale görüntüsü) 1990'lara uzanan randomize çalışmalarda gizli PTX'ların tüp dekompresyonuna gerek kalmadan izlenebileceği gösterilmiştir.7 Barrios ve ark. tarafından yapılan retrospektif bir çalışmada, 59 gizli PTX için tüp torakostomisiz tedavi denenmiş ve %86 başarı izlenmiştir. Pozitif basınçlı ventilasyona maruz kalanların başarı oranı ise %80 olup; tüp torakostomi yapılmadan başarılı bir şekilde tedavi edilen hastaların hiçbiri (n = 16) ölmemiştir.8 A. Pnömotoraksın Tanımlanması ve Fizyolojisi PTX röntgen, BT ya da USG ile tanımlandığında öncelikle hastanın kardiyopulmoner hemodinamisi değerlendirilir. Hasta instabil kabul edilirse acilen drenaj gereklidir. Çoğu zaman, instabilitenin PTX'in doğrudan sonucu olup olmadığı belirsizdir ve bu durumlarda PTX'i dren ile tedavi etmek daha güvenlidir. Bununla birlikte, küçük, yani röntgende 1 cm'den az veya BT taramasında 10 mm'den küçük olanlarda, PTX'in hastanın fizyolojisi üzerindeki etkisi muhtemelen ihmal edilebilir düzeydedir. B. Acil Drenaj Bulguları Randomize kontrollü çalışmalar ve 2019 tarihli meta-analiz sonuçlarına dayanarak profilaktik antibiyotik önerilmektedir. 9 Antibiyotik türü ve süresi hakkında çalışmalar arasında bir birlik olmasa da; ortak görüş ampiyem ve pnömoninin önlenmesi için mümkünse tüp takılmadan önce, değilse mümkün olan en kısa sürede antibiyotik verilmesidir. Antibiyotiğin işlemden sonra verilmesinin etkisi tartışmalıdır, ancak dozun işlemden önce veya mümkün olan en kısa sürede verilmesini önerilir....
Take Home Points: Lung ultrasound is simple, quick and accurate for real time, bedside assessment of your patient with acute undifferentiated dyspnea PTX: least dependent area, shallow depth, lung sliding, lung point CHF: scan across the 4 zones of the chest, look for B lines Bringing this to the bedside can give you diagnostic closure ... Read more The post REBEL Core Cast 72.0 – Lung US appeared first on REBEL EM - Emergency Medicine Blog.
Dr. Thomas Weiss is Vice President Hydrogen, PtX & Storage for TÜV SÜD's Industry Service divsion. He manages TUV SUD hydrogen projects all over the world - and shares his view on hydrogen certification, guarantees of origin for generated hydrogen gas and his opinion on collaboration and partnering models in the hydrogen industry.
Jun Bei Liu from Tribeca Investment Partners and Adam Dawes from Shaw and Partners go in-depth and stock specific. Stocks covered: MCR, BLX, YOJ, PTM, BBN, KZR, PTX, MHH, FCL, AFI. For our stocks for a 'crash' series Jun Bei Liu and Adam Dawes picked Aussie Broadband (ABB) and Endeavour (EDV) respectively. See acast.com/privacy for privacy and opt-out information.
This week's EYE ON NPI is from our best buds at Bud Industries - the Bud AIO Series Enclosure with Cover Window (https://www.digikey.com/en/product-highlight/b/bud-industries/aio-series-enclosure) is a very nice case that is a step above most durable wall-mounted enclosures. In particular, what is really nice about this design is there are two 'doors' - one is the main enclosure latching door that lets you stuff a whole bunch of electronics inside. There's also a secondary clear panel door on the front, which is also latching (although not with metal hasps). Both are gasketed for weatherproof-ness. Obviously, the front door is designed for showing TFTs, LEDs, gauges or other indicators with a protected cover. However, we like the extra step of being able to open the cover to push buttons, tweak knobs or maybe interact with a touch screen without opening up the whole box which could expose the electronic design to dust or dampness. Bud's great with their documentation (https://www.budind.com/wp-content/uploads/2020/12/hbaio11111.pdf) - and the two AIO series enclosures come with datasheets that have nice diagrams of all internal and external dimensions in inches and millimeters. There's lots of mounting holes/bosses on the inside for attaching a PCB or substrate - the holes are threaded and the enclosure comes with plenty of mounting screws. The enclosure is made of ABS plastic, which makes it very easy to drill and cut. (https://www.google.com/search?channel=nus5&client=firefox-b-1-d&q=abs+plastic+machining) There's a removable plate that sits between the inner and outer section, which means it's easy to remove for machining. If you need a lot of custom panels, it may also be possible to just cut out plastic/metal/wood on a router with the drill holes and slots you need. There's also internal panels you can purchase that fit inside the case with lots of holes for quick mounting (https://www.digikey.com/en/products/detail/bud-industries/PTX-10140/13907429) Another nice detail we noticed in our exploration is the gasket material is extruded and molded to the enclosure, rather than a simple o-ring or rubber bead. That's what gives it the nice IP66 rating (https://en.wikipedia.org/wiki/IP_Code) for dust-proof and waterjet-proofness. That said, because it's non-stabilized ABS, it isn't well suited for any long-term outdoor mounting as it can degrade under sunlight. It could be used outdoors as long as it isn't exposed to sunlight too much, but it's really designed for durable indoor use. IP66-rated enclosures are dust-tight and provide a strong level of indoor-outdoor protection. Boxes that qualify for this rating will prevent ingress of water directed at high pressure. Typically IP66 waterproof enclosures are used in washdown and outdoor applications, such as factories, rooftops, solar installations, and agricultural settings. They give maximum protection against pressure-washing and weather short of water immersion. https://www.budind.com/nema-ip-rated-boxes-ip-66 There's two versions of this enclosure with different depths: the Bud AIO-11111 (https://www.digikey.com/en/products/detail/bud-industries/AIO-11111/13907415) and the Bud AIO-11112 (https://www.digikey.com/en/products/detail/bud-industries/AIO-11112/13907416), the '11111 is 9.5" deep, the '11112 is 7.7" deep. Both are in stock right now for immediate shipment from Digi-Key! (https://www.digikey.com/short/4zznn9h3) Order today and you can have a cozy enclosure for your product or project by tomorrow morning. See on Digi-Key at https://www.digikey.com/short/4zznn9h3
It's the JournalFeed Podcast for the week of July 19-23, 2021. We cover treatment of blunt cerebrovascular injury, CNS and PNS side effects of metronidazole, chest POCUS or CXR for PTX, performance of the Canadian syncope rule in a different demographic, and more HEART score woes.
In today's episode, we speak with Grace Lambert, the bestselling author of How Did I Not Know About This? Becoming Pain Free Through Posture Therapy. Posture therapy helps people of all ages and abilities get themselves out of chronic pain, restore physical function and/or improve their balance or athletic performance. Grace didn't think enough people knew about the benefits of posture therapy, so she wrote her book t spread the word. Through stories of her own and those of her other Posture Alliance colleagues, she spreads the message of hope for reducing or eliminating pain. If you, or someone you know, experience chronic pain, you will want to listen to this interview. Grace shares practical advice on what you can do starting TODAY to move away from pain and back into doing all the things you love to do! Sit back and listen in as Grace Lambert shares her story! -------------- Grace Lambert is a PTX-licensed therapist and a posture alignment specialist, certified through the Egoscue Institute. She offers private sessions, classes and workshops through her business, Posture First Exercise Therapy. To connect with Grace, you can go to her website at https://www.posture-first.com or email her at grace@posture-first.com If you're interested in finding a posture therapist in your area, go to https://www.posturealignmenttherapists.com. You can also check out Pete Egoscue's work at https://www.egoscue.com.
Sommerferien står for døren – og dermed også enden på et politisk år, der meget naturligt primært har været fokuseret på corona. Men der er også sket en del indenfor energi og klima. Blandt andet har der været talt rigtig meget om sektorintegration i form af overskudsvarme og PtX, og støttemidler til konvertering fra individuel sort opvarmning til grøn varme. Gæster i studiet er vært på TV2 News, Troels Mylenberg og politisk chef i Dansk Fjernvarme, Rune Moesgaard.
Power-to-X eller PtX er et af de varme emner lige nu i energisektoren. Med PtX kan man via elektrolyse udnytte overskydende vindkraft og omdanne el til brint, der kan omsættes til andre formål – for eksempel flydende brændstof. Men den proces skaber også en god mængde overskudsvarme, hvorfor det er oplagt at udnytte varmen til fjernvarme. På den baggrund har Dansk Fjernvarme og fjernvarmens tænketank, Grøn Energi, i samarbejde med COWI og TVIS udarbejdet en rapport, der ser på potentialet for PtX og fjernvarme. Gæster i studiet er direktør i Dansk Fjernvarme, Kim Mortensen og direktør i TVIS, Jørgen Nielsen.
Petra Lorenz und Friedemann Kalmbach erörtern in Folge 8 mit Micha Schlittenhardt die Situation bei der Espira Kindertagesstätte in Knielingen, Karlsruhe. Wir stellen kurz die festgestellten Probleme bei der Studie zur Innenstadt während der Corona-Pandemia und wie eine autofreie Innenstadt möglich sein kann - und ob Park & Ride die Antwort sein kann ("Nein" sagt Petra Lorenz). Einen kurzen Blick auf die Luca App von Smudo und die Debatte um landwirtschaftliche Flächen des Biohof, der dem Sportvereinsflächen in Rüppur weichen müsste.
Vært: Henrik Heide Medvirkende: Bjørn Godske, Martin Bernth og Thomas Djursing I denne uges Transformator sætter vi fokus på de nye energiteknologier, der under fællesbetegnelsen power-to-x handler om at konvertere vindmøllestrøm til en energiform, der er let at lagre, f.eks. brint, e-methanol eller ammoniak. Der kastes for tiden milliarder i PtX-projekter rundt om i landet i et kapløb om at sætte sig på strategisk vigtige lokationer, f.eks. hvor der er adgang til vindmøllestrøm, og hvor overskudsvarmen kan udnyttes. Og så skal vi til Mars, hvor Nasa i sidste uge succesfuldt landede roveren Perseverance, hvis hovedmission er at tage prøver i et floddelta to kilometer væk, hvor der muligvis er levn fra fortidigt liv. Efter landingen tager roveren sig et hvil, lader batterierne op og opdaterer sin software. Og på en lydoptagelse kan du høre, hvordan marsvinden blæser. Vi slutter af fra Lynetteholmen – den planlagte kunstige ø, der skal rumme boliger til 35.000 nye københavnere og fungere som klimasikring af hovedstaden. Ingeniøren har tidligere stillet spørgsmålstegn ved VVM-proceduren, der ret usædvanligt er delt op i flere enkeltdele, selv om øen, den tilhørende metrolinje og havnetunnel til biler er et samlet projekt. Og nu protesterer svenskerne over de miljømæssige konsekvenser af at hælde mere end 2,3 millioner læs jord i Øresund. Links Nogle artikler kræver abonnement og er muligvis endnu ikke online Her er Danmarks PtX-planer Eksperter og branchefolk: Danmark har brug for en PtX-strategi Efter vild Mars-landing: Klar til labyrintræs og helikoptertest Leder: Svensk storm over Københavns prestige-ø
On this episode, Catie, Karen and Hassan get to chat with the sweetest, most supportive, most loyal Valentine: KATE! Get to know Kate with as you listen to her song of the week, hear her answers to her Valentine questions and all of her sweet stories. We also take a chance on answering lots of PTX trivia! Song of the Week Catie: Harmony to my Heartbeat- Sally Seltmann- https://www.youtube.com/watch?v=ctwRi-8A9jEKaren: Colors by Black Pumas https://t.co/TlTUVt3qsc?amp=1 Hassan: Cover of Closer (by the Chainsmokers) by Narin: https://t.co/s7XVOVK2iq?amp=1Kate: Save Us by Lennon Stella- https://t.co/MM9mRpiYJh?amp=1
#motorola #waveptx #radioteléfonoEl popular walkie-talkie está más vigente que nunca. Motorola Solutions innova al integrar la inmediatez del PTT (push-to-talk) con el alcance de las redes celulares. Lo mejor de 2 mundos en 1 solo servicio.
Link to bioRxiv paper: http://biorxiv.org/cgi/content/short/2020.10.12.336412v1?rss=1 Authors: Zhen, Y., Ewert, K. K., Fisher, W. S., Steffes, V. M., Li, Y., Safinya, C. R. Abstract: Lipid-based carriers of the hydrophobic drug paclitaxel (PTX) are used in clinical trials as next-generation agents for cancer chemotherapy. Improving the loading capacity of these carriers requires enhanced PTX solubilization. We compared the solubility of PTX in cationic liposomes (CLs) with lipid tails containing one (oleoyl; C18:1 {Delta}9 DOTAP/DOPC) or two (linoleoyl; C18:2 {Delta}9 DLinTAP/DLinPC) cis double bonds with newly synthesized cationic DLinTAP (2,3-dilinoleoyloxy-propyl-trimethyl-ammonium methylsufate). We used differential-interference-contrast microscopy to directly observe PTX crystal formation and generate kinetic phase diagrams representing the time-dependence of PTX solubility as a function of PTX content in the membrane. Replacing tails bearing one cis double bond (DO lipids) with those bearing two (DLin lipids) significantly increased PTX membrane solubility in CLs. Remarkably, 8 mol% PTX in DLinTAP/DLinPC CLs remained soluble for approximately as long as 3 mol% PTX (the membrane solubility limit which has been the focus of most previous fundamental studies and clinical trials) in DOTAP/DOPC CLs. The large increase in solubility is likely caused by enhanced molecular affinity between lipid tails and PTX upon replacement of oleoyl by linoleoyl tails, rather than by the transition in membrane structure from lipid bilayers to inverse cylindrical micelles observed in small-angle X-ray scattering. Importantly, the efficacy of PTX-loaded CLs against human prostate cancer (PC3) cells from measurements of the IC50 of PTX cytotoxicity was unaffected by changing the lipid tails, and toxicity of the CL carrier alone was negligible. Moreover, efficacy was approximately doubled against human melanoma (M21) cells for PTX-loaded DLinTAP/DLinPC over DOTAP/DOPC CLs. The findings demonstrate the potential of chemical modifications of the lipid tails to increase the PTX membrane loading well over the typically used 3 mol% while maintaining (and in some cases even increasing) the efficacy of CLs. The increased PTX solubility will aid the development of liposomal PTX carriers that require significantly less lipid to deliver a given amount of PTX, reducing side effects and costs. Copy rights belong to original authors. Visit the link for more info
Pentatonix - Bohemian Rhapsody (MUSIC REVIEW) Ty and Katie share their thoughts on the #PTX cover, Bohemian Rhapsody! --- This episode is sponsored by · Anchor: The easiest way to make a podcast. https://anchor.fm/app
On this episode of That's PTX To Me, our podcast co-hosts (Hassan, Catie, and Karen) discuss the Mad World video, design our own PTX merch, compete in a Christmas-themed Guess The Reversed PTX Song game, and more! Email us via thatsptxtome@gmail.com or tweet us @ThatsPTXToMe with your questions and comments! Enjoy!Songs of the Week:Karen: Paramore - Hallelujah: https://www.youtube.com/watch?v=_TYlOXVdVcQ Hassan: Metamorphosis - Always Been But Never Dreamed: https://www.youtube.com/watch?v=QeZne1wVyl0 Catie: Tori Kelly - Value: https://www.youtube.com/watch?v=OulDebHlSEI
On this episode of That's PTX To Me, our podcast co-hosts (Hassan, Catie, and Karen) are joined by a new Valentine, Hassan's wife Maheen! We discuss the Happy New music video and new Christmas music, compete on our favorite PTX original, and maybe even share some exclusive baby news. Email us via thatsptxtome@gmail.com or tweet us @ThatsPTXToMe with your questions and comments! Enjoy!Songs of the Week:Maheen: Ryann Darling - From Ashes: https://youtu.be/DpImmRhbhUsCatie: George Salazar - Michael in the Bathroom: https://www.youtube.com/watch?v=WaMRF8ucGJo Karen: Talos - To Each His Own: https://www.youtube.com/watch?v=NgTwJQ2CUqI Hassan: Bear McCreary - Agents of S.H.I.E.L.D. Overture: https://www.youtube.com/watch?v=mmTlWtHYX-M
On this episode of That's PTX To Me, our podcast co-hosts (Hassan, Catie, and Karen) discuss Mitch's new Patreon, review the latest music videos from PTX and Kevin, get hyped about the Happy Now trailer, and more! Email us via thatsptxtome@gmail.com or tweet us @ThatsPTXToMe with your questions and comments! Enjoy!Songs of the Week:Catie: Taylor Swift - invisible string: https://www.youtube.com/watch?v=OuFnpmGwg5k Karen: ATEEZ - INCEPTION: https://www.youtube.com/watch?v=2NArH91kHoQ Hassan: Mashin Sentai Kiramager - Kiraful Miracle Kiramager: https://youtu.be/iGmZod9X3LU
On this episode of That's PTX To Me, our podcast co-hosts (Hassan, Catie, and Karen) celebrate our ONE YEAR ANNIVERSARY!!! Plus, we reminisce about PentaCon, discuss the latest PTX music videos, and more! Email us via thatsptxtome@gmail.com or tweet us @ThatsPTXToMe with your questions and comments! Enjoy! Songs of the Week:Karen: BTS - Stay Gold: https://www.youtube.com/watch?v=9IHwqdz8Xhw&feature=youtu.beHassan: BLACKPINK - How You Like That: https://www.youtube.com/watch?v=ioNng23DkIM Catie: Anthony Ramos - Dear Diary: https://www.youtube.com/watch?v=rxIyYi4TX9s
On this special LIVE episode of That's PTX To Me, our podcast co-hosts (Hassan, Catie, and Karen) are joined by a group of Pentaholics to react to the brand new "At Home" EP from Pentatonix. We listen to the entire EP and give our thoughts, as well as discuss the upcoming schedule of content on PTX's website. Email us via thatsptxtome@gmail.com or tweet us @ThatsPTXToMe with your questions and comments! Enjoy!Pentatonix "At Home" EP Link:BUY/STREAM: https://smarturl.it/PTXATHOME
On this special LIVE episode of That's PTX To Me, our podcast co-hosts (Hassan, Catie, and Karen) are joined by many Pentaholics in the community! Listen to our Zoom call as we wish Kirstin Happy Birthday, talk about Scott and Rozzi's new podcast, speculate about PTX filming new videos, and even compete in a word association challenge! Email us via thatsptxtome@gmail.com or tweet us @ThatsPTXToMe with your questions and comments! Enjoy!
On this episode of That's PTX To Me, our podcast co-hosts (Hassan, Catie, and Karen) discuss all of the recent "quarantine" content from PTX, Kevin's new EP, the Messer debut, and more. Plus, we compete in another round of our challenging game where we rank PTX music videos based on view count! Email us via thatsptxtome@gmail.com or tweet us @ThatsPTXToMe with your questions and comments! Enjoy!Songs of the Week:Hassan: John Williams - Battle of the Heroes: https://www.youtube.com/watch?v=FHuD5y-PZM0 Catie: Kirstin - Good Morning Quarantine: https://www.youtube.com/watch?v=3O7B0OFpdSw Karen: Scott Hoying - Lament of the Inanimate Objects: https://twitter.com/scotthoying/status/1255945204034461697?s=20
On this special LIVE episode of That's PTX To Me, our podcast co-hosts (Hassan, Catie, and Karen) are joined by many Pentaholics in the community! Listen to our Zoom call as we discuss our fantasy tour set list, when we expect new content from PTX, and just hang out and enjoy each other's company during this trying time. Email us via thatsptxtome@gmail.com or tweet us @ThatsPTXToMe with your questions and comments! Enjoy!
On this episode of That's PTX To Me, our podcast co-hosts (Hassan, Catie, and Karen) celebrate the amazing Pentaholic community while we are all in lockdown. We answer your listener questions for our Bean Bag Chat segment and compete in a challenging game of ranking PTX music videos based on view count! Email us via thatsptxtome@gmail.com or tweet us @ThatsPTXToMe with your questions and comments! Enjoy!Songs of the Week:Catie: Demi Lovato - I Love Me: https://www.youtube.com/watch?v=vImvzQCb0o8Hassan: Animal Crossing: New Horizons - Main Theme: https://www.youtube.com/watch?v=MeJoAV0D8vY Karen: The Mandalorian - Main Theme: https://www.youtube.com/watch?v=SiGd8k55mWk
On this episode of That's PTX To Me, our podcast co-hosts (Hassan, Catie, and Karen) discuss the beautiful wedding of Kevin and Leigh Olusola, theorize about Pentatonix's October schedule and their upcoming Best of Christmas album, and perform dramatic readings of some PTX originals. Email us via thatsptxtome@gmail.com or tweet us @ThatsPTXToMe with your questions and comments! Enjoy!Songs of the Week:Karen: ONEUS - LIT: https://www.youtube.com/watch?v=ggPF6Wb8A50 Hassan: j-hope & Becky G - Chicken Noodle Soup: https://www.youtube.com/watch?v=i23NEQEFpgQ Catie: Dear Evan Hansen - You Will Be Found: https://www.youtube.com/watch?v=OMZZTrjWxt0 Relevant Links:People's article about Kevin & Leigh's wedding: https://people.com/music/pentatonix-kevin-olusola-marries-leigh-weissman-wedding-photos/Pentatonix's October schedule: https://twitter.com/PTXofficial/status/1179158984550256640?s=20
On the fifth episode of That's PTX To Me, our podcast co-hosts (Hassan, Catie, and Karen) discuss the new Tik Tok obsession, speculate about the big tease that PTX has released, and test our musical knowledge with a fun new game. Email us via thatsptxtome@gmail.com or tweet us @ThatsPTXToMe with your questions and comments! Enjoy!Songs of the Week:Catie: Mean Girls on Broadway - “I’d Rather Be Me”: https://youtu.be/B-dywz4L6Y8Karen: Hamilton - “Wait for It”: https://www.youtube.com/watch?v=ulsLI029rH0Hassan: ODESZA - “Loyal”: https://www.youtube.com/watch?v=Sz_YPczxzZcRelevant Links:Pentatonix teasing: https://twitter.com/PTXofficial/status/1170094322940706816?s=20
On the third episode of That's PTX To Me, our podcast co-hosts (Hassan, Catie, and Karen) are joined by our first "Pentaholic Valentine" Liz! We get to know her and learn about her love of tracking stats for PTX. Plus, we discuss the new tour outfits and attempt to play more games with varying degrees of success. Email us via thatsptxtome@gmail.com or tweet us @ThatsPTXToMe with your questions and comments! Enjoy!Songs of the Week:Karen: ATEEZ - Utopia https://www.youtube.com/watch?v=wnnjxIs8aCA Liz: Sasha Sloan - Thoughts: https://www.youtube.com/watch?v=T37QFDQak9MHassan: RIOT - Overkill: https://www.youtube.com/watch?v=qPlUNAI7qV4Catie: Tori Kelly - Unbreakable Smile: https://m.youtube.com/watch?v=CVOvhKCYKAc
Its is absolutely necessary to switch to the linear transducer when looking for lung sliding (i.e., PTX)? While the linear will definitely give you the best image, watch this video to see my thoughts on using the curvilinear and even the phased array in the eval of lung sliding! While continuing to my work with revamping the Ultrasound Leadership Academy's curriculum, I had this thought. Maybe we don't need to switch every time? Check it out! Want more ultrasound goodness? Check out my other podcasts, ultrasoundpodcast.com and ultrasoundgel.org. If you'd like to come scan with us in my beautiful Bend, Oregon at Bendfest19.com!
I absolutely love PTX and i hope you guys like my little talk about them
This month we have Liver Disease with Katherine Henderson | Sexual Assault | RCEM Flourishing Medical Careers with Matthew Cooke, Taj Hassan and Pro Mukherjee | Death in Children | Moral Injury | New in EM Conservative Rx of PTX in trauma | New in EM ICH in minor head injury in anticoagulation | Ambulatory PE, and an overall wellness episode
On this episode of Next on the Tee we look back at the Masters and get reactions from "The Voice of Golf" Peter Kessler plus former PGA Tour Pro, now Broadcaster for Sirius/XM's PGA Tour channel, Paul Stankowski. I'm also joined by Ben Hogan Golf CEO Scott White and we talked about their return to the golf equipment business business plus details about their PTx and Fort Worth irons as well as their new Forged Edge irons and Equalizer wedges.
On this edition of Next on the Tee my guests are: Ben Hogan Golf Company CEO Scott White and Dr. Bob Jones IV, Grandson of Bobby Jones. Scott White - Scott took us through how the brand has emerged from bankruptcy and their new factory to the consumer business model which has cut cost out of their business and results in huge savings for consumers. We talked about the construction and technology in their PTx and Fort Worth irons, their TK wedges as well as ther hybrids. He also gave us peak into what they are developing for 2018. Dr. Bob Jones IV - Doc talked about his recent trip to St. Andrews including a walking tour of the Old Course. He talked about the legend that his Grandfather once tore up his scorecard after visiting the Hill Bunker on the 11th hole. We talked about how incredibly deep the Hell Bunker is on 17, as well as what it feels like as you walk a course that every legend of the has played. Doc is a Sports Psychologist so we discussed tips for dealing with pressure during a tournament and how we can help our junior golfers deal with playing in front of a crowd for the first time.
What could be better than hanging out behind the scenes at Endless Noise studios and getting insider info from the audio engineer and producers who have worked with Superfruit and Pentatonix for the last 5 years? All of that plus a 5 bottle “blind” Bourbon tasting! (And that’s exactly what we do with Mary Catherine Finney and Grant Cornish who have known the PTX crew longer than almost anybody in showbiz. Join us!) Guests: Grant Cornish & Mary Catherine Finney For pictures and more from this episode, visit forksontheleft.com Follow us on Twitter (@forks_ontheleft), Instagram (forks_ontheleft) and Facebook. Please rate us and leave us a review on iTunes!
This episode covers Chapter 77 of Rosen’s Emergency Medicine. The Pleural Space is not to be trifled with! List 5 RFs for 1° spontaneous PTX. What is the most common pathophysiologic cause of PTX? List 8 causes of 2° spontaneous PTX List 5 clinical findings suggestive of tension PTX Describe how to estimate the size of a PTX Describe the management of 1° and 2° spontaneous PTX Describe the procedure needle aspiration of a PTX. List 3 benefits of this over TT Describe the procedure of TT. List 6 complications of TT placement and contraindications. List 10 causes of pleural effusion. What is the most common transudative and exudative? What is starling’s law and how does it apply to the development of pleural effusions List 5 CXR findings of pleural effusion Describe Light’s Criteria for pleural effusion and list 5 other tests to perform on pleural fluid. What does a low pH indicate? Describe the procedure of thoracentesis. List 2 contraindications and 9 complications Wise Cracks What is Catamenial pneumothorax? How is it tx? How do you properly Secure a chest tube? Describe the seldinger technique for chest tube insertion What are the false positives for PTX on lung U/S?
This episode covers Chapter 77 of Rosen’s Emergency Medicine. The Pleural Space is not to be trifled with! List 5 RFs for 1° spontaneous PTX. What is the most common pathophysiologic cause of PTX? List 8 causes of 2° spontaneous PTX List 5 clinical findings suggestive of tension PTX Describe how to estimate the size of a PTX Describe the management of 1° and 2° spontaneous PTX Describe the procedure needle aspiration of a PTX. List 3 benefits of this over TT Describe the procedure of TT. List 6 complications of TT placement and contraindications. List 10 causes of pleural effusion. What is the most common transudative and exudative? What is starling’s law and how does it apply to the development of pleural effusions List 5 CXR findings of pleural effusion Describe Light’s Criteria for pleural effusion and list 5 other tests to perform on pleural fluid. What does a low pH indicate? Describe the procedure of thoracentesis. List 2 contraindications and 9 complications Wise Cracks What is Catamenial pneumothorax? How is it tx? How do you properly Secure a chest tube? Describe the seldinger technique for chest tube insertion What are the false positives for PTX on lung U/S?
Background: Ischemia/reperfusion (I/R) injury plays a pivotal role in the development of graft pancreatitis, with ischemia time representing one of its crucial factors. However, it is unclear, whether exocrine and endocrine tissue experience similar inflammatory responses during pancreas transplantation (PTx). This study evaluated inflammatory susceptibilities of islets of Langerhans (ILH) and exocrine tissue after different preservation periods during early reperfusion. Methods: PTx was performed in rats following 2 h (2h-I) or 18 h (18h-I) preservation. Leukocyte-endothelial cell interactions (LEI) were analyzed in venules of acinar tissue and ILH in vivo over 2 h reperfusion. Nontransplanted animals served as controls. Tissue samples were analyzed by histomorphometry. Results: In exocrine venules leukocyte rolling predominated in the 2h-I group. In the 18h-I group, additionally, high numbers of adherent leukocytes were found. Histology revealed significant edema formation and leukocyte extravasation in the 18h-I group. Notably, LEI in postcapillary venules of ILH were significantly lower. Leukocyte rolling was only moderately enhanced and few leukocytes were found adherent. Histology revealed minor leukocyte extravasation. Conclusion: Ischemia time contributes decisively to the extent of the I/R-injury in PTx. However, ILH have a significantly lower susceptibility towards I/R, even when inflammatory reactions in adjacent exocrine tissue are evident. Copyright (C) 2010 S. Karger AG, Basel
Tierärztliche Fakultät - Digitale Hochschulschriften der LMU - Teil 03/07
In der vorliegenden Arbeit wurden funktionelle Besonderheiten des klonierten equinen Histamin H1 Rezeptors (eH1) aufgeklärt. Insbesondere wurde die agonistvermittelte Regulation von Oberflächenrezeptoren sowie die intrazelluläre Signaltransduktion im Vergleich zum humanen Histamin H1 Rezeptor (hH1) dargestellt. Die Studie erfolgte an stabil die nativen eH1 bzw. hH1 oder die entsprechenden EGFP-Fusionsproteine exprimierenden HEK 293-Zellen. Die verwendeten Zellklone (HEK-hH1 und HEK-eH1) wiesen eine vergleichbare Rezeptorendichte auf. Im Vergleich zum hH1 induziert Histamin am eH1 nur eine geringe Internalisierung des Rezeptors, ein Effekt der sowohl mittels Radioligandenbindung an intakten Zellen als auch im konfokalen Mikroskop (LSM) nachgewiesen wurde. Die Internalisierung des eH1 erfolgt clathrinabhängig unter Beteiligung der GRK 2 und β-Arrestin 1. Dagegen scheint die Internalisierung des hH1 clathrinunabhängig mittels Lipidvesikel abzulaufen. Die klinische Wirksamkeit von Antihistaminika korreliert stark mit ihrer negativ intrinsischen Aktivität. Dabei zeigt der eH1 im Vergleich zum hH1 eine deutlich geringere spontane oder konstitutive Aktivität. Diese spiegelt sich in einer niedrigeren basalen GTPy35S Bindung (Rezeptor/G-Protein Kopplung) wieder, die in Anwesenheit von Diphenhydramin zunimmt. Das Antihistaminikum weist demnach am eH1 eine partielle agonistische Aktivität auf. Aufgrund seiner niedrigen konstitutiven Aktivität wird über den equinen Histamin H1 Rezeptor in HEK 293-Zellen keine basale ERK 1/2 Aktivierung induziert, so dass in diesem System keine dem Diphenhydramin am hH1 entsprechende inverse Aktivität bestimmt werden kann. Im Gegensatz zu hH1 führt die Aktivierung des eH1 mit Histamin zu einer sehr starken Stimulation der intrazellulären cAMP-Akkumulation. Diese ist im Vergleich zum hH1 nicht PTX- und PLC-abhängig, während beide Rezeptoren über PKA- und PKC-abhängige Mechanismen an die Adenylatcyclase (AC) gekoppelt sind. Zusammenfassend weisen die Ergebnisse auf vielfältige funktionelle und regulatorische Besonderheiten des equinen Histamin H1 Rezeptors hin, die bei der klinischen Anwendung und Entwicklung neuer Antihistaminika beim Pferd berücksichtigt werden müssen.
Tierärztliche Fakultät - Digitale Hochschulschriften der LMU - Teil 02/07
Regulation of adenylate cyclases and extracellular signal-regulated protein kinases by delta-opioid receptors in HEK293 cells Stimulation of G protein coupled opioid receptors result in both inhibition of adenylate cyclases and stimulation of extracellular signal-regulated protein kinases ERK1/2. As regulation of cellular effectors may be accomplished by various G proteins as well as by the different G protein subunits (G alpha, G betagamma), delta-opioid receptors were thus examined for activating different G proteins underlying different regulation of these cellular effectors. In transfected HEK293 cells, activation of delta-opioid receptors by peptidergic opioids (DADLE, DPDPE) and alkaloids (etorphine, morphine) brought about concentration-dependent inhibition of adenylate cyclases and stimulation of the ERKs, respectively. Since the high-affinity opioids DADLE, DPDPE and etorphine accomplished regulation of respective effector molecules already at nanomolar ligand concentrations, a 1000-fold higher dose of low-affinity agonist morphine was required for both inhibition of adenylate cyclases and ERK activation. However, for all tested opioids, a higher EC50 could have been determined for inhibition of adenylate cyclases than for stimulation of the ERKs. Thus, adenylate cyclases expressed in HEK cells seems to be more sensitive to delta-opioid receptor activation than the ERKs. As previously shown, exposure of HEK-DOR cells to pertussis toxin (PTX) resulted in incomplete inhibition of adenylate cyclases by DADLE and DPDPE, whereas etorphine and morphine totally lost their ability to inhibit the cyclases under these conditions. In contrast, activation of ERKs by all tested opioids was abolished by PTX treatment. However, PTX also blocked ERK activation by Gq-coupled receptors and receptor tyrosine kinases, both regulating ERKs independent from PTX-sensitive Gi proteins. Thus, PTX is suggested to inhibit ERK activation also independent from affecting G protein activation. Since inhibition of G alpha q subunits by the G alpha q-binding protein EBP50 did not affect effector regulation, inhibition of G alpha q and G alpha 12 mediated signaling by neomycin and 1-butanol brought about partial blockade of ERK activation by all tested opioids. Exposure of HEK-DOR cells with neomycin and 1-butanol together even totally blocked ERK activation by respective opioids. In contrast, inhibition of G alpha 11 signaling partially blocked inhibition of adenylate cyclases by DADLE and DPDPE, whereas regulation of the cyclases by the alkaloids was not affected under this condition. Since inhibition of G betagamma signaling by phosducin did not affect regulation of adenylate cyclases and ERKs by opioids, delta-opoioid receptors are supposed to regulate these cellular effectors by G alpha subunits. Although the tested cellular effectors are regulated differently, inhibition of adenylate cyclases seems to support activation of ERKs, since simultaneous stimulation of the cyclases by forskolin impairs ERK activation by DPDPE and etorphin. In contrast, activation of ERKs did not affect regulation of the cyclases by delta-opioid receptors. Together the findings let suppose that different G alpha subunits might be involved in regulation of adenylate cyclases and ERKs by delta-opioid receptors. Since stimulation of delta-receptors might be supposed to bring about inhibition of adenylate cyclases by G alpha i and G alpha 11 subunits, alkaloids seems to regulate cyclases by G alpha i subunits. In contrast, both peptide and alkaloid opioids seem to stimulate ERKs by G alpha 11- and G alpha 12-mediated signaling.
Tierärztliche Fakultät - Digitale Hochschulschriften der LMU - Teil 01/07
In der vorliegenden Studie ist anhand von weiblichen Fischer-344-Ratten tierexperimentell erforscht worden, welche Applikationsform von Calcitriol (1,25(OH)2D3), die per subkutaner Injektion, die per Schlundsonde oder die oral über das Futter, den stärksten knochenanabolen Effekt erzielt und die stärkste Suppression der PTH-Sekretion zur Folge hat. In einem weiteren Tierexperiment wurde der Frage nachgegangen, in welchem Umfang die PTH-Suppression eine Rolle bei der antiresorptiven Wirkung von Calcitriol spielt, und ob diese antiresorptive Wirkung von Calcitriol als direkter oder indirekter Effekt am Knochen zu verstehen ist. Im ersten Versuch sind 72 weibliche, sechs Monate alte Fischer-344-Ratten in acht Gruppen eingeteilt und mit Vehikel, 0.05 oder 0.10 µg/kg KG Calcitriol entweder oral über das Futter, oral über Schlundsonde oder über subkutane Injektion zwei Wochen lang behandelt worden. Für den zweiten Versuch wurden sechs Monate alte weibliche Fischer-344-Ratten scheinoperiert (n = 24) oder parathyreoidektomiert (n = 48). Der Erfolg der Parathyreoidektomie ist über die Messung des ionisierten Kalziums im Blut einen Tag post operationem überprüft worden. Einem Teil der parathyreoidektomierten Tiere (n = 24) wurde über osmotische Minipumpen Ratten-PTH (1-34) mit konstanter Rate infundiert, um bei diesen PTX-Tieren eine Normalisierung der Blutkalziumspiegel und PTH-Blutspiegel zu generieren. Alle drei Tiergruppen (SHAM, PTX und PTX+PTH) bekamen oral über das Futter zwei Wochen lang täglich Vehikel, 0.05 oder 0.10 µg/kg KG Calcitriol. Am 5. und 1. Tag vor den Versuchenden erhielten alle Tiere eine Flourochrom-Doppelmarkierung mit Calcein. Die statische und dynamische histomorphometrische Auswertung der Semidünnschnitte, die von unentkalkt in Methylmetacrylat eingebetteten Knochen gewonnen wurden, erfolgte über halb- und vollautomatische Analyseverfahren. Mit der peripheren quantitativen Computertomographie (pQCT) sind weitere Knochenparameter, darunter die Knochenmineraldichte an Tibia und Lendenwirbelkörper bestimmt worden. Aus dem Serum und dem Urin der Ratten sind knochenrelevante Parameter mit in die Beurteilung der Experimente einbezogen worden. Die Applikation von Calcitriol über die drei verschiedenen Wege zeigte unterschiedliche Wirkungen auf den Knochenstoffwechsel, so war die Bone Formation Rate (BFR) in der oral über das Futter behandelten Gruppe am stärksten ausgeprägt. Die Calcitriol-Fütterung bewirkte am Lendenwirbelkörper, nicht aber an der proximalen Tibiametaphyse, eine deutlich gesteigerte Zunahme der gesamten Knochenfläche, der Bone Area. Die gesamte Knochenmineraldichte erfuhr, verglichen mit den Kontrolltieren, in allen behandelten Gruppen eine Zunahme. Eine verminderte Knochenresorption bewirkte allerdings nur die orale Gabe von Calcitriol über das Futter. Die scheinoperierten Ratten im zweiten Tierexperiment haben bezüglich der ausgewerteten Knochenparameter gute Übereinstimmung mit der Fütterungsgruppe aus dem ersten Experiment gezeigt. Der Vergleich der parathyreoidektomierten Tiere ohne PTH-Substitution zu denen mit PTH-Substitution ergab, dass der antiresorptive Effekt von Calcitriol, gemessen Anhand der Deoxypyridinolin-Ausscheidung über die Nieren, unter der Aufrechterhaltung eines konstanten Blut-PTH-Spiegels deutlich erkennbar war. Diese Feststellung weist auf einen direkten antiresorptiven Effekt von Calcitriol am Knochen hin. Die Ergebnisse der vorliegenden Studie lassen erkennen, dass die Applikationsart einen wichtigen Einfluss auf die durch Calcitriol induzierten Effekte am Knochen bei der Ratte besitzt. Der antiresorptive Effekt von Calcitriol ist nicht allein über die Suppression der PTH-Sekretion vermittelt, sondern auch über einen direkten antiresorptiven Effekt von Calcitriol am Knochen.
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