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In this episode of Going Anti-Viral, Dr Raymond Schinazi joins host Dr Michael Saag for an in-depth conversation about the development of a cure for hepatitis C. Dr Schinazi, the Frances Winship Walters Professor of Pediatrics and Director of the Laboratory of Biochemical Pharmacology at Emory University, shares insights from his distinguished career in antiviral research and development. He begins by outlining his background and long-standing interest in antiviral therapies, including groundbreaking work in HIV treatment. The conversation then shifts to his pivotal role in the development of sofosbuvir, a breakthrough direct-acting antiviral drug in the cure for hepatitis C, and the importance of NS5A inhibitors in antiviral drug regimens. Dr Schinazi also offers a rare behind-the-scenes look at the business and regulatory journey of bringing a transformative therapy to market, reflecting on the personal impact of this milestone. The episode concludes with a discussion of his current research into potential treatments for hepatitis B. 0:00 – Introduction1:24 – Overview of Dr Schinazi's background and his interest in antiviral therapy2:56 – Discussion of Dr Schinazi's work in the development of antiviral agents for HIV4:45 – Background on the development of sofosbuvir for the cure of hepatitis C10:01 – The role of NS5A inhibitors in treatment12:42 – History of bringing hepatitis C treatment to market14:25 – Discussion of the effectiveness of NS5A inhibitors 16:49 – The risk of reinfection and review of the basic science behind pharmaceuticals for hepatitis C18:22 – How the discovery of a hepatitis C cure impacted Dr Schinazi personally25:16 – Overview of Dr Schinazi's current research in Hepatitis B__________________________________________________Produced by IAS-USA, Going anti–Viral is a podcast for clinicians involved in research and care in HIV, its complications, and other viral infections. This podcast is intended as a technical source of information for specialists in this field, but anyone listening will enjoy learning more about the state of modern medicine around viral infections. Going anti-Viral's host is Dr Michael Saag, a physician, prominent HIV researcher at the University of Alabama at Birmingham, and volunteer IAS–USA board member. In most episodes, Dr Saag interviews an expert in infectious diseases or emerging pandemics about their area of specialty and current developments in the field. Other episodes are drawn from the IAS–USA vast catalogue of panel discussions, Dialogues, and other audio from various meetings and conferences. Email podcast@iasusa.org to send feedback, show suggestions, or questions to be answered on a later episode.Follow Going anti-Viral on: Apple Podcasts YouTubeXFacebookInstagram...
Je vous présente Félix Lacerte Gauthier, journaliste indépendant. Formellement chez Québecor, Le Devoir, et Métro Média. Nous discutons de la job de journaliste ici au Québec. Notamment on se penche sur la loi controversée du C18 qui a pour but de taxer Google et Meta a payé une redevance au gouvernement pour balancer les fonds des médias. En parallèle on aborde les 2500 emplois dans les médias qui ont été perdus. Comme média indépendant, pour nous c'est une discussion importante d'avoir la perspective d'un journaliste qui œuvre dans ce domaine et quel impact cela provoque sur l'industrie. Bonne écoute. 00:05:20 - Journaliste pour Denis Coderre et Valerie Plante 00:08:54 - La vie de journaliste 00:11:15 - Comment es-tu rentré dans le journalisme 00:13:33 - Le plus gros conflit au QC 2023 00:14:45 - La différence entre un journaliste et un chroniqueur 00:16: 16 - La diversité à montreal / j'ai été le premier a interviewé Tai 00:19:32 - Fournir de l'information au publique objectivement 00:23:00 - L'opinion sur les créateurs qui partagent des nouvelles 00:24:34 - La loi C-18 00:29:00 - Le but de cette loi - L'équilibre des revenus médiatiques 00:34:20 - 2500 postes de coupé au Canada dans les médias 00:36:35 - L'accord de Google de 100 millions 00:40:50 - Bâtir une communauté 00:44:30 - il faut sensibilisé le publique 00:47:11 - Est-ce qu'il y a de nouvelles opportunités pour les journalismes 00:49:20 - L'avenir est avec les indépendants 00:56:50 - Marketing pour les médias 01:02:30 - Le recensement de Yellow Seats
一、思想問題：當世人在哀嘆生命的短暫有限，念天地之悠悠，獨愴然而涕下時；我們短暫的生命有什麼盼望呢？ 二、鑰節： 102:27 惟有你永不改變；你的年數沒有窮盡。102:28 你僕人的子孫要長存；他們的後裔要堅立在你面前。 這世界一切都會改變，天地要如外衣漸漸舊了，而惟有神是永遠不變，祂是我們的標竿與盼望，認識主、敬畏事奉主的人必然長存，生命、家庭要永遠被主堅立；這是無懼的人生，這是得勝的人生。 三、經文結構： A1-11 哀嘆人的年日短少。 →B12-17 神的永恆，與憐憫。 →→C18-22 後代要永遠讚美神。 A23-24 哀嘆人的日子短少。 →B24-27 神的永恆，24世世無窮 。 →→C28 後代讚美。 四、結構亮光： 本篇詩篇提到詩人正面對極大的苦難，可能是身體疾病，也可能是國破家亡的苦境，不斷地強調人生命的短暫與痛苦；但是當轉眼看見神，就看見那超越短暫苦難的永恆主在掌管一切，因此發出大讚美。 本篇結構採ABCABC平行結構，A是哀嘆人年日短少，B是看見神的永恆，C是後代要讚美神。 A的部分： vv.1-11與vv.23-24出現了七次「日子」：v.2急難之日、呼求之日、v.3消滅之日、v.8辱罵之日、v.11將亡之日、v.23短少之日、v.24中年去世之日，表達了人生命年歲的短少，而在這短少的日子中，又充滿了許多的急難、羞辱、死亡等威脅。 在這樣的苦情中，詩人向神禱告呼求，v2求主不要掩面、不要塞住耳朵。 其中用了許多生動筆法來形容人的苦情：v.3骨頭如火把燒著，v.4心好像草一般的枯乾，v.11日子好像草一般要消失，v.6又好像不潔淨的鵜鶘、鶚鳥等被人排斥，v.7好像最孤單的麻雀，被人撇棄，v.9我吃爐灰、喝眼淚；再再表達自己無法訴說的苦情。 B的部分： 而v.12,24b是轉捩點，從自己的短暫轉眼看見神的永恆。v.12「惟你─耶和華」、v.24「你的年數」，都提到了「萬代（1755）」，v.12神的名存到萬代，v.18後代人要記下並且讚美，因v.24神的年數世世無窮。人看自己是短暫痛苦的，但是看見神的永恆，生命開始有了新的座標、新的眼光、新的價值與智慧。 v.12神是永恆的，存到萬代，並且在永恆的權柄中，要重新憐憫、祝福錫安（v.13,16），v.14可憐聖殿的石頭。很可能此時已經國破家亡了，而詩人正為著國家哀慟時，卻轉眼看見神要重新地憐恤、可憐，並重新地建造，使神的榮耀回到錫安，這是詩人真正的盼望。 而vv.24b-27是更廣闊的眼光，不只是解決一個國家的問題，更是解決所有人類、受造物的問題：為什麼我們今天會在這麼多的眼淚、嘆息中？出路在哪裡？ v.24神的年數世世無窮，v.25從創造的起點，神立的大地根基，神所創造的天，v.26而直接跳到世界的終了，有一天天地要滅沒，外衣漸漸舊了（這與熱力學第二定律相同，也與宇宙膨脹論相同），但是神沒有改變，並且神要重新再做一次創造的工作。 v.27這世界萬物都會改變，但是神永遠不改變，這一段偉大的時間論、永恆論，被新約希伯來書1:10-12引用，以此證明聖子的神性，成為希伯來書13:8的背景：來13:8 耶穌基督昨日、今日，一直到永遠，是一樣的。 C的部分： 認識神永恆的人，看人生有什麼不同的眼光呢？vv.18-22,28回答了這個問題。提到了後代、將來受造的民、子孫（v.28）、後裔，不只是我這一代有指望，而是世世代代、子子孫孫都有一個極大的盼望：v.18我們可以讚美神，v.21傳揚神、讚美神的話，v.22萬國要聚集事奉神，v.28長存堅立在神的面前。 自古至今，人在尋找永恆、尋找長生不老之術，從秦始皇派徐福去尋找蓬萊仙人；到春秋魯國大夫孫叔豹提到三不朽，追求精神上的永恆；到尼采、佛教涅槃的永恆觀等，沒有一種藥物與思想可以給人充滿動力的永恆觀，惟有認識永恆的主，我們的生命才能得著極大的喜樂與盼望，我們當好好把握現在，並過著盼望永恆的每一天。 五、反省問題： 我是否體會人生苦短？我的盼望在哪裡？神的永恆與我的盼望有什麼關係？ 認識永恆的人，與眼中只有今天的人，在面對人生、後代有什麼不同的看法？什麼是永恆的盼望？ －－－－－－－－－－－－－－－－ 講員： 貴格會合一堂 徐坤靖牧師 聖經之鑰-各卷書播放清單： https://thfc.pse.is/3epsdf 【聖經之鑰 相關資源】YouTube： https://thfc.pse.is/3cfams電子書： https://thfc.pse.is/3ccluu Powered by Firstory Hosting
Dans cet épisode intégral du 3 novembre en entrevue : Mélanie Hubert, présidente de la Fédération autonome de l'enseignement (FAE). Entrevue avec Annabelle Blais, journaliste au Bureau d'enquête du Journal de Montréal. Une production QUB Radio Novembre 2023Pour de l'information concernant l'utilisation de vos données personnelles - https://omnystudio.com/policies/listener/fr
Dominique Olivier se la joue gouverneure générale avec l'argent des Montréalais. La fin définitive du Publisac. On décortique la géopolitique du Moyen-Orient. Dans cet épisode intégral du 3 novembre en entrevue : Benoît Chartier, président du conseil d'administration d'Hebdos Québec. Pierre Pahlavi, membre de l'Observatoire sur le Moyen-Orient et l'Afrique du Nord de la Chaire Raoul-Dandurand et professeur titulaire au Collège des Forces canadiennes de Toronto. Une production QUB Radio Novembre 2023Pour de l'information concernant l'utilisation de vos données personnelles - https://omnystudio.com/policies/listener/fr
Dans cet épisode intégral du 3 novembre en entrevue : Denis Turcotte, vice-président de l'Association des directeurs de police du Québec et directeur du Service de police de la ville de Québec (SPVQ). Jean-François Dumas, président d'Influence communications. Aref Salem, Chef de l'Opposition officielle à l'Hôtel de ville de Montréal et conseiller de la Ville dans l'arrondissement St-Laurent pour Ensemble Montréal. Une production QUB Radio Novembre 2023Pour de l'information concernant l'utilisation de vos données personnelles - https://omnystudio.com/policies/listener/fr
547 employés du Groupe TVA perdent leur emploi : est-ce que les fonctionnaires sont conscients de la chance qu'ils ont d'avoir une sécurité d'emploi? À l'Office de Consultation publique, on ne mange pas de la marde ! Il est maintenant possible de se faire prescrire du temps en nature et Mich Dans cet épisode intégral du 3 novembre en entrevue : Isabelle Bradette, professeure à la Faculté de médecine et des sciences de la santé de l'Université de Sherbrooke et ambassadrice de Prescri-Nature (le premier programme québécois de prescriptions d'exposition à la nature basée). Yvan Cliche, spécialiste sur les questions d'énergie et membre du CÉRIUM. Alain Saulnier, professeur retraité en communications à l'Université de Montréal et ex-directeur général de l'information de Radio Canada. Une production QUB Radio Novembre 2023Pour de l'information concernant l'utilisation de vos données personnelles - https://omnystudio.com/policies/listener/fr
My guest this week is Kris Sims, Alberta Director for the Canadian Taxpayers Federation and a strong voice for common sense, an end to government waste and a return to smaller, more affordable, more accountable government. This week, we discuss the recent Supreme Court pipeline decision that overturned Bill C-69, the Liberals' attempted hijacking of provincial jurisdiction over natural resource development and transport. Kris also shares her deep concerns about the alarming new attempts by the government and the CRTC to restrict free speech on the internet. Visit the Canadian Taxpayers Federation at: https://www.taxpayer.com
Dr. Jay Bhattacharya and Rav Arora join John Carpay on stage for a fireside chat during the George Jonas Freedom Award dinner in Calgary on September 28. They discuss the free speech lawsuit that involves Dr. Bhattacharya, Missouri v. Biden. They also talk about the failure of the Canadian government bills C18 and C10, and the fall of the mainstream media with the corresponding rise of new media.The Illusion of ConsensusJustice Centre, Jun 23, 2021: Lockdowns and the Science of Covid, Dr. Jay BhattacharyaGreat Barrington DeclarationEvent Tickets: Ben Shapiro Calgary, AB - Grey Eagle Resort & CasinoJustin Hart in the Wall Street Journal, Dec 9, 2022: The Twitter Blacklisting of Jay BhattacharyaThe New York Post, Dec 12, 2022: Elon Musk invites blacklisted Stanford professor to Twitter headquartersThe Hill, Sep 13, 2023: Missouri v. Biden and the crossroads of politics, censorship and free speechWAFB Dec 5, 2022: Louisiana, Missouri Release Full Fauci Deposition TranscriptJustice Centre, Aug 31, 2021: Student reinstated after University of Winnipeg had kicked her out for attending peaceful outdoor protestTablet, Jan 10, 2023: How Stanford Failed the Academic Freedom TestAmerican Pediatric Society, Sep 9, 2020: Open Letter from Stanford University Regarding Dr. Scott AtlasCalgary Herald, Sep 24, 2021: Alberta Children's Hospital doctors face criticism for letters opposing vaccine mandateJustice Centre, Sep 27, 2021: Justice Centre will defend physicians threatened by Alberta College of Physicians and SurgeonsNational Post, Sep 21, 2023: Canada launches UN declaration pledging measures on online disinformationTheme Music "Carpay Diem" by Dave StevensSupport the show
As traditional news organizations have faced a steady decline, the online local news network Village Media has been thriving in small and medium-sized communities. But as the government and tech giants have gotten into a standoff over Bill C-18, the Online News Act, Village Media has been forced to pause their growth. Their CEO Jeff Elgie talks to Paul about how C-18 has hurt his business, and what's at stake. You can get a premium version of this show with extra content by subscribing to Paul's newsletter: paulwells.substack.com
Dans les soirées d'Azoulay, Raphael Azoulay s'est entretenue avec Simon-Pierre Savard-Tremblay, député de Saint-Hyacinthe Bagot, qui nous explique le projet de loi c-18 et de l'impact des géants du Web sur les médias locaux.See omnystudio.com/listener for privacy information.
We continue the interview with Matt Croyle and James Langford, two Strength and Conditioning coaches with British Triathlon. They answer listener questions, including how to find the time to do some S and C and how to fit it in to your week. You'll hear:In part 2 of the interview, I start by asking Matt what exercises people can do to help them get stronger for the bike…00:00 Exercises that people can do to help them with their biking.02:00 What about exercises that people can do to help with the running? Lower body exercises will be useful to help your body tolerate high forces. Focus on the foot and ankle too.08:00 What about core work? Matt talks about the trunk, any of the muscles that are helping to support the spine. So anything that helps to keep you standing up straight. ‘You should be looking to overload the trunk' Matt mentions how working on your back can help reduce back pain on the bike.13:00 Do yoga and pilates help?14:00 Nia: How do you ensure some strength and conditioning when time is tight?16:00 John's Question: Any tips for motivation when it comes to S and C18:00 David asks about ‘leg day' and how you factor it in and what it might look like. James says that building up gradually and then being consistent is really important when it comes to S and C.22:00 Do triathletes need to be flexible?25:00 Glutes – How can you get your glutes firing?27:00 Matt and James explain there are different ways to go about Strength and Conditioning. Doing something is better than nothing.Find out more about this week's guest:Matt Croyle InstagramJames Langford InstagramLike what you heard?Let me know! Connect with Inside Tri Show across Social Media, just search Inside Tri Show or click on the icons belowGET YOUR HANDS ON AN EXCLUSIVE EPISODE!Sign up to be a vino buddy or a training buddy on Patreon and get your hands on two patrons-only episodes a year. Or just support the show by buying Helen a coffee every month by becoming a coffee buddy Patreon of the Inside Tri Show.Listener DiscountsFor 15% Discount on FORM Swim goggles: https://www.formswim.com/pages/insidetrishowOTE Sports, 20% off with the code INSIDE-TRI-20This podcast uses the following third-party services for analysis: Podcorn - https://podcorn.com/privacy
1. Intro 2. Antiquity 3. Crusaders 4. Middle Ages 5. C18 6. C19 7. C20 8. postscript Jamie goes solo to keep you up to speed with tech, tactics and time honoured aspects in war, conflict and adversity. These 'Bloody Bites' are short podcast episodes which will hopefully answer a few questions thrown up in our general podcast discussions. A kind of BVH glossary.Let us know if you would like to hear Jamie's take on a particular topic. talk@bloodyviolenthistory.comSo It GoesTom Assheton & James Jackson See also:YouTube: BloodyViolentHistoryhttps://www.instagram.com/bloodyviolenthistory/https://www.jamesjacksonbooks.comhttps://www.tomtom.co.uk If you enjoy the podcast, would you please leave a short review on Apple Podcasts/iTunes, Spotify or Google Podcast App? It takes less than 60 seconds, and it really helps to spread the wordSee https://simplecast.com/privacy/ for privacy information
Live with Darren and Graham going over some current events and topics that are not really getting discussed. Why aren't people discussing the major lawsuit against the Government of Canada from some Native Indian Tribes. We chat about natural resources in Canada, the land issue with the indigenous tribes, the land timeline and the possibility of revoking the Indian Act. What is Meta going to do about C18? Is Mainstream Canadian news completely tone deaf? Is Meta bluffing? Does the mainstream media just want more money from big tech because their platforms and model in utterly failing with all the lies and government money? Canada's war on Natural health just after the start up of The Wellness Company's Canadian division. And in the meantime Health Canada calls for the end of capitalism and colonialism, and says racism causes global warming. There is a Venn diagram where we overlap with the woke crowd with colonialism. A small overlap. See links to stuff we chatted about: https://twccanada.health/ https://brightlightnews.com/is-natural-healthcare-finished-in-canada/ Buckely says in the next few years natupathic industry is done. https://farmersforum.com/health-canada-calls-for-end-of-capitalism-says-racism-causes-global-warming-2/ https://www.rebelnews.com/advocates_warn_that_health_canada_s_sweeping_natural_product_regulations_will_decimate_the_industry https://nhppa.org/wp-content/uploads/2023/06/Discussion-Paper-On-2023-Health-Canada-Initiatives-C-47-Cost-Recovery-and-Burdens-New-Powers.pdf https://www.itworldcanada.com/article/meta-confirms-it-will-end-news-availability-for-canadians-as-bill-c-18-passes/541609 https://www.justice.gc.ca/eng/csj-sjc/pl/charter-charte/c18_1.html https://atlantic.ctvnews.ca/bill-c-18-could-dramatically-alter-news-media-consumption-on-social-platforms-1.6454426 https://openmedia.org/press/item/deeply-flawed-online-news-bill-c-18-passes-without-key-fixes https://thenarwhal.ca/ontario-treaty-9-lawsuit/ https://www.aptnnews.ca/nation-to-nation/we-never-surrendered-our-rights-treaty-9-nations-launching-95b-claim-lawsuit-against-canada-ontario/ Subscribe to our PLUS feed for more of these but more controversial - chats and second half of interviews for audio and podcast please clink the link http://www.grimericaoutlawed.ca/support. For Video's of more of these but more controversial and the second half of video interviews (when applicable and audio) go to our Substack and Subscribe. https://grimericaoutlawed.substack.com/ or to our Locals https://grimericaoutlawed.locals.com/ Help support the show, because we can't do it without ya. If you value this content with 0 ads, 0 sponsorships, 0 breaks, 0 portals and links to corporate websites, please assist. Many hours of unlimited content for free. Thanks for listening!! Support the show directly: https://grimerica.ca/support-2/ Our Audiobook Site: www.adultbrain.ca Our Audiobook Youtube Channel: https://www.youtube.com/@adultbrainaudiobookpublishing/videos Grimerica Media Youtube Channel: https://www.youtube.com/@grimerica/featured Darren's book www.acanadianshame.ca Check out our next trip/conference/meetup - Contact at the Cabin www.contactatthecabin.com Other affiliated shows: www.grimerica.ca The OG Grimerica Show www.Rokfin.com/Grimerica Our channel on free speech Rokfin Join the chat / hangout with a bunch of fellow Grimericans Https://t.me.grimerica https://www.guilded.gg/chat/b7af7266-771d-427f-978c-872a7962a6c2?messageId=c1e1c7cd-c6e9-4eaf-abc9-e6ec0be89ff3 Get your Magic Mushrooms delivered from: Champignon Magique Mushroom Spores, Spore Syringes, Best Spore Syringes,Grow Mushrooms Spores Lab Get Psychedelics online Leave a review on iTunes and/or Stitcher: https://itunes.apple.com/ca/podcast/grimerica-outlawed http://www.stitcher.com/podcast/grimerica-outlawed Sign up for our newsletter http://www.grimerica.ca/news SPAM Graham = and send him your synchronicities, feedback, strange experiences and psychedelic trip reports!! graham@grimerica.com InstaGRAM https://www.instagram.com/the_grimerica_show_podcast/ Purchase swag, with partial proceeds donated to the show www.grimerica.ca/swag Send us a postcard or letter http://www.grimerica.ca/contact/ ART - Napolean Duheme's site http://www.lostbreadcomic.com/ MUSIC Tru Northperception, Felix's Site sirfelix.bandcamp.com
Au programme :La fin des SkyblogsMidJourney 5.2 et un Patrick IA plus vrai que natureLe Canada passe la loi C18 et Meta répliqueMeta sur le fediverse et les effets sur MastodonL'influence des modes TikTokLe moment TwitterQuelques infos légalesLe reste de l'actualitéLiens :
Greetings! This week's program honors the life and music of Finnish composer Kaija Saariaho who passed away on June 2. In addition, a bunch of new items and some older random things to sweeten the pot. Enjoy! Joel e-mail: pushingtheenvelopewhus@gmail.com Twitter: https://twitter.com/envpusher1 6-10-23 PTE Playlist Hypogean - Robert Scott Thompson - Placid - Aucourant Records (2023) https://robert-scott-thompson.bandcamp.com/album/placid RIP Kaija Saariaho Changing Light for soprano & violin - soprano: Luyba Petrova / violin: Edna Mitchell / composer: Kaija Saariaho - The Compassion Project - Innova (2018) https://www.innova.mu/albums/edna-michell/compassion-project NoaNoa for flute & electronics - flute: Camilla Hoitenga / composer: Kaija Saariaho - Electro Acoustic Muisc III - Neuma Records (1994) https://neumarecords.bandcamp.com/album/electro-acoustic-music-iii Pale Blue - Glen Whitehead - Pale Blue - Neuma Records (2023) https://glenwhitehead.bandcamp.com/album/pale-blue In A Silent Way / Shhh/Peaceful / It's About That Time - Miles Davis - Panthalassa: The Music fo Miles Davis 1969-1974 > reconstruction & mix translation by Bill Laswell - Columbia (1998) https://www.milesdavis.com/albums/panthalassa-the-music-of-miles-davis-1969-1974/ Is It That Dark? (excerpt) - cornet/electronics: Graham Haynes / sound design: Hardedge - Is It That Dark? - Hardedge (2008) https://www.hardedge.net/ startled deer resume their dreams in the clouds - David Beardsley - klang and the silver cord - digital release (2023) https://davidbeardsley.bandcamp.com/album/klang-and-the-silver-cord Ragas in minor scale (Phase duo version) - Phase Duo / composers: Philip Glass & Ravi Shankar - Minimal Electric Music - digital release (2019) https://stefanogreco.bandcamp.com/album/minimal-electric-music C18 - pä (Paulo da Fonseca) - Hone nami (bone wave) - digital release (2023) https://lesondouble.bandcamp.com/album/hone-nami The Emerald Path to Redemption - Joseph Benzola - The Emerald Path to Redemption - digital release (2023) https://josephbenzola.bandcamp.com/album/the-emerald-path-to-redemption Killer B - Skyjelly - Spirit Guide مرشد حقيقة - digital pre-release (2023) https://skyjelly.bandcamp.com/album/spirit-guide Song and Whispers - viola: Kimia Hesabi / composer: Gity Razaz - Nemāno Gaona (“colors of home”) - New Focus Recordings (2023) https://newfocusrecordings.bandcamp.com/album/nem-no-gaona Some Kind of Symmetry - Seawind of Battery (Mike Horn) / Ryley Walker / Jarrod Annis - Some Kind of Symmetry: Live at Room 31, New York City – 1/26/23 - digital release (2023) https://seawindofbattery.bandcamp.com/track/some-kind-of-symmetry-with-ryley-walker-jarrod-annis-live-at-room-31-new-york-city-1-26-23
1. La victime du jour : sélectionnée pour le titre, une jeune femme utilisant les pronoms vir/vamp parce que s'identifie comme vampire se fait déclasser par la voiture de Valérie Plante qui se mange un ticket de stationnement parce quelle est stationné tout croche en avant de l'hôtel de ville de Montréal ! Yves Poirier est au front. 2. Un parc de Montréal demande aux gens de ne pas nourrir les oiseaux pour ne pas provoquer d'écrasements d'avions... 3. Sondage : La Miata chauffe le Chrysler Sebring avec un deuxième sondage de suite mettant le PQ 2e. Les libéraux sont à 4% chez les francos. 4. Meta et Google entravent l'accès au contenu de certains médias canadiens en représailles à C18. PKP et quelques plantes vertes fédérales sont outrés ! On essaie de comprendre leur revendication et une conclusion s'impose : le gouvernement va cracher le cash ! Dans la PARTIE BONUS PATREON, on parle de Joe Cormier qui aurait choqué une école avec une joke de «morning wood» ainsi que de la Ville de Lyon, en France, qui subventionne une performance botanique jubilatoire écosexuelle où des gens se foutent à poil avec des strap on devant des enfants qui regardent un homme nu qui suce des roches... On parle ensuite d'un québécois qui est parti se faire opérer au dos à Cuba pour 18k$ ! Frank pète un plomb sur le dômien en question. --- Send in a voice message: https://podcasters.spotify.com/pod/show/ian-snchal/message
Review các phim ra rạp từ ngày mùng 1 âm lịch Tết Quý Mão 2023 NHÀ BÀ NỮ C16 Đạo diễn: Trấn Thành Diễn viên: Trấn Thành, Lê Giang, NSND Ngọc Giàu, Uyển Ân, Khả Như, NSND Việt Anh, NSUT Công Ninh, Ngân Quỳnh, Song Luân, Lê Dương Bảo Lâm, Lý Hạo Mạnh Quỳnh, Phương Lan, Hoàng Mèo,... Thể loại: Gia đình Phim xoay quanh gia đình của bà Nữ (nghệ sĩ Lê Giang đảm nhận) - người làm nghề bán bánh canh. Truyện phim khắc họa mối quan hệ phức tạp, đa chiều xảy ra với các thành viên trong gia đình. Câu tagline (thông điệp) chính "Mỗi gia đình đều có những bí mật" chứa nhiều ẩn ý về nội dung bộ phim muốn gửi gắm. CHỊ CHỊ EM EM 2 C18 Đạo diễn: Vũ Ngọc Đãng Diễn viên: Minh Hằng, Ngọc Trinh, Lê Giang,... Thể loại: Hài, Tâm Lý Dựa trên giai thoại mỹ nhân Ba Trà & Tư Nhị, Chị Chị Em Em 2 xoay quanh giai đoạn 2 đệ nhất mỹ nhân Ba Trà và Tư Nhị gặp gỡ nhau, từ đó tái hiện cuộc sống hoa lệ nhiều góc khuất tại Sài thành cách đây một thế kỷ... PHI VỤ TOÀN SAO C16 Đạo diễn: Guy Ritchie Diễn viên: Jason Statham, Aubrey Plaza, Hugh Grant,... Siêu điệp viên Orson Fortune cùng đồng đội lên kế hoạch điên rồ hòng tóm gọn tay trùm buôn vũ khí khét tiếng. MÈO BÉO SIÊU ĐẲNG Đạo diễn: Toby Genkel, Florian Westermann Diễn viên: Hugh Laurie, Emilia Clarke, David Thewlis, Himesh Patel, Gemma Arterton, Hugh Bonneville, David Tennant, Rob Brydon, Julie Atherton, Joe Sugg. Thể loại: Hoạt Hình Maurice - một chú mèo ngốc nghếch biết nói với biệt tài lừa đảo kiếm tiền siêu đỉnh. Darktan - chỉ huy của đàn chuột tinh quái đang có âm mưu với người bạn Maurice của mình về một hòn đảo thiên đường, nơi mà loài chuột và con người sống hòa bình với nhau. Liệu trò lừa đảo này của đôi bạn có bị phát hiện? Maurice và Darktan sẽ gặp những bất ngờ gì trên chuyến phiêu lưu đến hòn đảo thiên đường? XÁC ƯỚP: CUỘC PHIÊU LƯU ĐẾN LONDON Đạo diễn: Juan Jesús García Galocha Diễn viên: Joe Thomas, Eleanor Tomlinson, Celia Imrie, Hugh Bonneville, Sean Bean, Dan Starkey, Santiago Winder. Thể loại: Hoạt Hình Sâu dưới lòng đất, một vương quốc xác ướp với lịch sử cả ngàn năm đang rất thịnh vượng. Theo thông lệ, công chúa Nefer phải kết hôn với Thut dù cả hai đều không bằng lòng với chuyện này. Nhưng vì không thể thoát khỏi yêu cầu của thần, Thut bắt buộc phải kết hôn với Nefer trong vòng 7 ngày, cùng với chiếc nhẫn các Pharaoh đã ban cho anh. Bước ngoặt xảy ra khi chiếc nhẫn bị đánh cắp, vậy nên cả Thut, Nefer cùng cậu em trai Sekhem và chú cá sấu đáng yêu Croc cùng nhau chu du đến London nhằm tìm lại chiếc nhẫn quý giá, và rồi nhận ra những thay đổi trong trái tim mình. PORORO: CUỘC PHIÊU LƯU ĐẾN DINH THỰ RỒNG Đạo diễn: Yoon Je-wan, Seunghoon Kang. Diễn viên: Kim Hyun-ji, Imiza, Jung Mi-sook, Kim Seo-young, Hong So-young... Thể loại: Hoạt Hình Chim cánh cụt đáng yêu Pororo sẽ trở lại vào dịp Tết này với một chuyến phiêu lưu mới. Lần này là cuộc phiêu lưu đến Dinh Thự Rồng. Tên phù thủy xấu xa Gad đang tìm cách đánh cắp 'Trái tim Rồng', một viên ngọc được phong ấn bằng sức mạnh to lớn của vua rồng nhỏ Arthur. Trong khi đó, Crong, người đã vô tình hấp thụ sức mạnh của 'Trái tim rồng', biến thành một Crong khổng lồ và khiến Pororo và những người bạn của cậu gặp nguy hiểm. Arthur, Pororo và những người bạn phải đến Dinh Thự Rồng tham gia vào trận chiến để lấy lại sức mạnh từ tay phù thủy độc ác. Liệu Pororo có thể bảo vệ Dinh Thự Rồng và cứu lấy những người bạn của mình? --- Support this podcast: https://podcasters.spotify.com/pod/show/kim-thanh-duong/support
CanadaPoli - Canadian Politics from a Canadian Point of View
Trump has a big announcement Donald Trump and What i meant. They used his presidency to advance their cause and burn down the country that he loves. I hope there is a plan. But fundamentally we have to do this ourselves. Canada is not broken says Trudeau House adjourned for the year C18 and c11 pass the house and senate ... Read More The post 1170 Canada is Broken appeared first on CanadaPoli.
Listen in podcast appCheck out learning corner for Joel's favorite company deep dive of the week.* Market update/forecast* Canada is done raising rates* Dave Portnoy's new watch brand* How Call of Duty parent company makes money* Sovereignty Act thoughts* LinkedIn Jobs report* Meghan and Harry Netflix Show* Recommendations and PredictionsListen on Apple, Spotify, or Google Podcasts.If you aren't in the Reformed Millennials Facebook Group join us for daily updates, discussions, and deep dives into the investable trends Millennials should be paying attention to.
Mark Ceilley of St. Paul has picture books on the mind, as a debut author himself. On a recent trip through Minneapolis-St. Paul International Airport, Ceilley discovered Picture Book Parade. The series features one picture book by a Minnesota author every two months through next August. Individual pages are blown up on panels so that visitors may feel they are stepping into the story. The book for this month and next is “In Search of the Gingerbread Man” by Timi Bliss, followed in 2023 by Peter Pearson's “How to Eat an Airplane,” Molly Beth Griffen's “Ten Beautiful Things,” Cheryl Minnema's book “Johnny's Pheasant” and Bao Phi's “A Different Pond.” The exhibit is located between gates C18 and C19 at Terminal 1. Wendy Knox of Frank Theatre stopped at Prove Collective in Duluth to see Carolyn Sue Olson's work. Olson created a series of brightly colored oil pastel portraits of essential workers, beginning with the stay-at-home order in March 2020 and continuing through July 2021. The portraits have been on display in various locations around the state, but this is the first time all 100 have been exhibited together. Olson has put the complete series in a book, which is available through her website. The show runs until Nov. 18. Knox found encountering the entire collection a powerful experience. “You forget certain things that have happened” over the course of the pandemic, Knox said, “it is a little stroll down a not-pleasant memory lane, but it is really informative to see” what we've been through. Breanne Tepler, lead singer/songwriter of Breanne Marie and the Front Porch Sinners, loves the art and music scene in Duluth. This Thursday evening, she's heading to Wussow's Concert Cafe, which she calls “the heart and soul of the Duluth music scene,” for a concert and artist's opening reception. The artist is Annmarie Geniusz, a “wickedly talented” Duluth-based artist who creates joyful, whimsical creative works, from illustrations and murals to stained glass creations. Geniusz will be the November featured artist at Wussow's, and the artist's reception will feature local ska band, Woodblind, from 6 p.m. to 8 p.m. Tepler also says to check out the mural Geniusz painted next door Wussow's, at Zenith Bookstore.
Review các phim ra rạp từ ngày 16/09/2022 QUÁI VẬT SÔNG MEKONG C16 Đạo diễn: Lee Thongkham Diễn viên: Sushar Manaying, Teerapat Satjakul, Vithaya Pansringarm, Wanmai Chatborirak, Lamyai Haithongkham, Thanachart Tulyachart, Eed Ponglang Thể loại: Kinh Dị Một con quái vật bí ẩn bỗng xuất hiện từ sông Mekong và tấn công vùng Bueng Kan, nó phá hủy mọi thứ và khiến người dân bị mất kết nối hoàn toàn với thế giới bên ngoài. Sự kiện chấn động toàn Thái Lan này đã khiến các cơ quan chức năng cùng những nhà khoa học vô tình đến Bueng Kan để tiến hành nghiên cứu phải huy động tất cả các lực lượng để bắt con quái vật điên rồ này trước khi quá muộn. NÔ LỆ CỦA QUỶ 2 C18 Đạo diễn: Joko Anwar Diễn viên: Tara Basro, Endy Arfian, Bront Palarae, Nasar Annuz, v.v Thể loại: Kinh Dị Những sự kiện kinh hoàng xảy ra trong một chung cư cũ dần hé mở bí ẩn tâm linh từ quá khứ khi một gia đình thực hiện giao ước với quỷ. LỖI LOGIC C18 Đạo diễn: Kim Soo Jung Diễn viên: Park Seo Ham, Park Jae Chan Thể loại: Tình cảm Là phiên bản điện ảnh của Web-drama bùng nổ nhất Hàn Quốc đầu năm 2022. Choo Sang Woo - một cậu nhóc khô khan, máy móc, sống trong những khuôn khổ đầy tính logic. Jang Jae Young - chàng trai tài hoa, lãng tử, luôn bỏ qua mọi quy tắc để sống hết mình với đam mê, niềm vui tuổi trẻ. Hai con người, hai kim chỉ nam trái ngược nhau về lẽ sống nhưng lại cùng nhau chạm đến “định mệnh”. Cuộc sống tưởng chừng như gặp đầy “lỗi” bỗng chốc như trải đầy hoa. BỘ TỨ DỊ GIỚI: THẾ GIỚI SONG SONG C13 Đạo diễn: Minoru Ashina Diễn viên: Aoi Yoki, Jun Fukushima, Kaito Ishikawa, Rie Takahashi, Saori Hayami, Satoshi Hino, Sora Amamiya Một ngày nọ, một nút bấm ma thuật đột nhiên xuất hiện. Sự kiện này là căn nguyên tạo nên sự giao thoa giữa nhóm các nhân vật chính của Bộ Tứ Dị Giới đến từ sáu loạt light novel nổi tiếng gồm KonoSuba, Overlord, Re:Zero − Starting Life in Another World, và Saga of Tanya the Evil khi tất cả đồng thời cùng ấn nút và di chuyển tới thế giới song song – một Isekai hoàn toàn mới với câu chuyện mới được mở ra trong bối cảnh cuộc sống tại trường trung học. Không lâu sau, nhóm kết nạp thêm các thành viên chính từ The Rising of the Shield Hero và Cautious Hero: The Hero Is Overpowered but Overly Cautious. Isekai mới này được cai trị bởi một con golem mất kiểm soát. Họ chạm trán với một nữ yêu tinh có tính cách tương tự Megumin, một người đàn ông cầm gậy có vẻ như quen biết với Subaru và một người phụ nữ mặc trang phục giống Tanya. Tất cả sẽ phải cố gắng để trở lại thế giới của mình. --- Support this podcast: https://anchor.fm/kim-thanh-duong/support
Review các phim ra rạp từ ngày 08/07/2022 THOR: TÌNH YÊU VÀ SẤM SÉT C13 Đạo diễn: Taika Waititi Diễn viên: Chris Hemsworth, Tessa Thompson, Natalie Portman, Chris Pratt Thể loại: Hành Động, Phiêu Lưu, Thần thoại Vốn từng là một chiến binh hùng mạnh của Asgard, trải qua vô số trận chiến lớn nhỏ nhưng sau sự kiện trong Avengers: Endgame (2019) cùng vô số mất mát, Thần Sấm không còn muốn theo đuổi con đường siêu anh hùng. Từ đây, anh lên đường tìm ra ý nghĩa của cuộc sống và nhìn nhận lại bản thân mình. XÁC SỐNG 32s C18 Đạo diễn: Gustavo Hernández Diễn viên: Paula Silva, Daniel Hendler, Pilar Garcia, Franco Rilla Thể loại: Kinh Dị Dịch bệnh xác sống bùng phát, dẫn đến hàng loạt vụ thảm sát rùng rợn trên các con phố của Montevideo (Uruquay). Kẻ nhiễm bệnh trở nên khát máu và liên tục sát hại những ai chưa mắc bệnh một cách tàn bạo. Không hay biết gì về điều này, Iris và con gái dành cả ngày tại câu lạc bộ thể thao nơi cô làm nhân viên bảo vệ. Khi đêm đến, đàn thây ma bắt đầu tấn công nơi này khiến Iris phải cố gắng chiến đấu để sống sót. Hy vọng duy nhất của họ là đám xác sống sẽ đứng yên trong 32 giây sau khi hạ sát một con mồi. --- Support this podcast: https://anchor.fm/kim-thanh-duong/support
We're back with Part 2 of our interview with Norman Radow, CEO of the RADCO Companies. It's was a conversation too good, we couldn't fit it into just one episode! In Part 2, we talk about the present and future of Norman's company plus the valuable lessons he's learned along his way to the top. EPISODE NOTES:01:13 - Present and future 13:56 - A, B, C18:54 - The indicators 22:16 - Characteristics of a good hotel investment 24:46 - New ideas on hotels 27:07 - An exit strategy 29:29 - Don't fall in love with the real estate 30:47 - A couple regrets 33:40 - What's next?35:31 - The Hot Seat presented by KK Reset
Cory explains the WEF plans, why we should pay attention to them, and what they will do. John Molberg of the new Buffalo Party of Alberta joins the show Professor Michael Geist discusses federal Bills C-11 and C18 and the risks they present to free speech and press.
Review các phim ra mắt tại các rạp từ ngày 22/04/2022 NGHỀ SIÊU DỄ C16 Đạo diễn: Võ Thanh Hòa Diễn viên: Hứa Vĩ Văn, Thu Trang, Kiều Minh Tuấn, Tiến Luật, Huỳnh Phương, Quang Tuấn, Vũ Ngọc Anh, Thanh Mỹ Thể loại: Hài, Hành Động Ông Thái là một cảnh sát về hưu nhưng không chịu an phận thủ thường, hàng ngày vẫn đi tìm bắt tội phạm vặt trong xóm cho đỡ nhớ nghề. Một ngày kia, Hoàng - tên trùm ma túy mới ra tù bỗng dưng chuyển đến xóm ông và mở một văn phòng bất động sản. Nghi ngờ đây là nơi làm ăn phi pháp, ông Thái quyết định âm thầm điều tra. Ông mua lại tiệm cơm tấm đối diện trụ sở của Hoàng để làm nơi theo dõi, đồng thời thu nạp Thu - Phú - Vinh - Mèo, đám thanh niên “bất hảo” trong xóm về quán hỗ trợ buôn bán để rảnh tay "phá án". Trớ trêu thay, tiệm cơm bất ngờ nổi tiếng và ăn nên làm ra, khiến cho "chuyên án đặc biệt" của ông đứng trước nguy cơ đổ bể. NGÀY 24...C18 Đạo diễn: Patrick Ridremont Diễn viên: Eugénie Derouand, Honorine Magnier, Clément Olivieri Thể loại: Hồi hộp, Kinh Dị Sau tai nạn xe hơi, cô vũ công ba lê Eva (Eugénie Derouand) đành giã từ sân khấu trong đau đớn và phải gắn bó với chiếc xe lăn trong suốt quãng đời còn lại. Một đêm nọ, cô bạn Sophie (Honorine Magnier) tới thăm và tặng cho Eva một món quà nhân dịp sinh nhật vào ngày Giáng Sinh sắp đến. Mỗi ngày cho tới ngày 24/12, Eva sẽ ăn một viên kẹo trong hộp và những điều kì diệu lần lượt xảy ra. Nhưng đó là phép màu trong truyện thần tiên hay là cái bẫy kinh hoàng do quỷ dữ mang lại? CHẠY TRỐN ĐỐI ĐẦU C18 Đạo diễn: Kyle Rankin Diễn viên: Isabel May, Cindy Vela, Eli Brown, Olly Sholotan,… Thể loại: Hành Động, Hồi hộp Bộ phim kể về một trường trung học bị bao vây bởi một bộ tứ học sinh xả súng. GÁNH NẶNG NGÀN CÂN CỦA TÀI NĂNG KIỆT XUẤT C16 Đạo diễn: Tom Gormican Diễn viên: Nicolas Cage, Pedro Pascal, Neil Patrick Harris... Thể loại: Hài, Hành Động Nick Cage (do chính Nicolas Cage thủ vai) là diễn viên từng đoạt giải Oscar đang gặp khó khăn về tài chính. Để nhận được khoản thù lao kếch xù 1 triệu USD lẫn giải cứu vợ con mình, anh phải đến dự tiệc sinh nhật của fan cuồng kiêm trùm tội phạm biến thái Javi. SEVENTEEN POWER OF LOVE: THE MOVIE Đạo diễn: OH Yoon-Dong Diễn viên: SEVENTEEN Thể loại: Phim tài liệu Nhóm nhạc toàn cầu SEVENTEEN đang viết lại lịch sử Kpop trong dự án điện ảnh đầu tiên! Sau hàng loạt những giải thưởng như đạt album bạch kim tại Hàn Quốc, nằm trong bảng xếp hạng Billboard 200 của Mỹ trong 2 tuần liên tiếp cùng nhiều thành tích nổi bật khác trong bảng xếp hạng Oricon ở Nhật Bản, SEVENTEEN đã chứng minh sự thành công và sức ảnh hưởng của nhóm khi đang dần thống trị các bảng xếp hạng âm nhạc trên toàn cầu. Đừng bỏ lỡ SEVENTEEN POWER OF LOVE : THE MOVIE với những màn trình diễn mạnh mẽ cùng lời chia sẻ từ quá khứ đến hiện tại, cũng như những dự định trong tương lai mà 13 chàng trai muốn gửi gắm tới CARAT sẽ lần đầu được tiết lộ trong các cuộc phỏng vấn chuyên sâu! BIỆT ĐỘI PHI HÀNH CÚN Đạo diễn: Inna Evlannikova Thể loại: Hoạt Hình Một xoáy nước kì lạ và nguy hiểm bất ngờ xuất hiện tại vùng biển Đại Tây Dương, thu hút sự chú ý của biệt đội phi hành cún. Được cử đến khu vực này để điều tra, hai phi hành cún quả cảm – Bạch Kim và Ánh Dương - đã khám phá ra một âm mưu to lớn đe doạ đến Trái Đất. Cùng với sự giúp đỡ của những người bạn tốt bụng, bộ đôi quyết định tìm cách ngăn chặn mưu đồ này, giải cứu Trái Đất và bảo vệ hoà bình vũ trụ. --- Support this podcast: https://anchor.fm/kim-thanh-duong/support
Cuộc trò chuyện về hậu trường thực hiện phim Đêm tối rực rỡ cùng đạo diễn Aaron Toronto, diễn viên Nhã Uyên, diễn viên Diễm Phương và Kim B. Phim bắt đầu trình chiếu tại các rạp từ ngày 08/04/2022 ĐÊM TỐI RỰC RỠ C18 Đạo diễn: Aaron Toronto Diễn viên: Kiến An, Phương Dung, Nhã Uyên, Xuân Trang, Diễm Phương, Kim B Thể loại: Hồi hộp, Tâm Lý Khi người ông qua đời, cả gia đình của Xuân Thanh (Nhã Uyên) tề tựu để đưa tiễn. Đám tang diễn ra hoành tráng, xôm tụ và đầy màu sắc. Bỗng dưng một đám người kéo đến đòi nợ trong sự ngỡ ngàng của tất cả. Những bí mật bị phanh phui, bi kịch chồng bi kịch, như một hệ luỵ tổn thương của nạn bạo hành gia đình đầy ám ảnh. --- Support this podcast: https://anchor.fm/kim-thanh-duong/support
Review các phim ra rạp từ ngày 08/04/2022 QUA BỂN LÀM CHI C16 Đạo diễn: Nguyễn Trung Cang Diễn viên: Thuận Nguyễn, Quang Minh, Duy Khánh, Phương Titi, Peter Phạm… Thể loại: Hài, Tình cảm Phim theo chân Tuấn (Thuận Nguyễn) – chàng sinh viên khoa tài chính điển trai đến Mỹ và sinh sống cùng chú Út (Quang Minh) của mình. Tại đây, anh đã gặp trợ lý của chú mình là Leo (Duy Khánh) - một anh chàng “say" anh như điếu đổ và có cuộc đụng độ đầy bất ngờ với Julie (Phương TiTi) ngay tại…phòng tắm! Một ngày, anh và Julie bất ngờ nhận được một đề nghị đầy cám dỗ từ Leo...và mọi việc bắt đầu rối tung lên theo một cách không ai lường trước được. ĐÊM TỐI RỰC RỠ C18 Đạo diễn: Aaron Toronto Diễn viên: Kiến An, Phương Dung, Nhã Uyên, Xuân Trang, Diễm Phương, Kim B Thể loại: Hồi hộp, Tâm Lý Khi người ông qua đời, cả gia đình của Xuân Thanh (Nhã Uyên) tề tựu để đưa tiễn. Đám tang diễn ra hoành tráng, xôm tụ và đầy màu sắc. Bỗng dưng một đám người kéo đến đòi nợ trong sự ngỡ ngàng của tất cả. Những bí mật bị phanh phui, bi kịch chồng bi kịch, như một hệ luỵ tổn thương của nạn bạo hành gia đình đầy ám ảnh. SINH VẬT HUYỀN BÍ: NHỮNG BÍ MẬT CỦA DUMBLEDORE C13 Đạo diễn: David Yates Diễn viên: Eddie Redmayne, Mads Mikkelsen, Ezra Miller, Katherine Waterston, Jude Law,… Thể loại: Phiêu Lưu, Thần thoại Câu chuyện của phần phim thứ ba này xoay quanh việc Giáo sư Albus Dumbledore (Jude Law) phát hiện ra việc Phù thủy Bóng tối quyền năng Gellert Grindelwald (Mads Mikkelsen) đang âm mưu chiếm lấy quyền kiểm soát Thế giới Phù thủy. Không thể một mình ngăn chặn đoàn quân hùng mạnh của của Grindelwald, Dumbledore đặt niềm tin vào Nhà nghiên cứu sinh vật huyền bí Newt Scamander (Eddie Redmayne) cùng đồng đội thực hiện nhiệm vụ đầy hiểm nguy này. Trong tình thế ngàn cân treo sợi tóc như vậy, liệu thầy Dumbledore có thể đứng ngoài được bao lâu? ÁC MỘNG C18 Đạo diễn: Adam Stilwell Diễn viên: Andrea Londo, Shawn Ashmore, Jane Badler,… Thể loại: Kinh Dị Sau khi cố gắng tự lấy mạng sống của mình, một phụ nữ trẻ phải vật lộn với một người chồng “kỳ lạ”. --- Support this podcast: https://anchor.fm/kim-thanh-duong/support
From paper bullets to Tibetan rituals, early printing presses to present day recycling: Laurence Scott explores the cultural and social history of paper, from the Chinese Han Dynasty in 105 AD to the 20th-century workplace. His guests are: Adam Smyth, a Professor of English Literature and the History of the Book at the University of Oxford. His books include Material Texts in Early Modern England; Book Destruction from the Medieval to the Contemporary (co-edited with Dennis Duncan) and Book Parts: A collection of essays on the history of parts of a book; Therese Weber, an artist who has made paintings out of pulp, paper tearing and dipping and is the author of The Language of Paper: A History of 2000 Years; Nicholas Basbanes, a writer and journalist, whose books include On Paper: The Everything of its Two Thousand Year History and Emily Cockayne, an Associate Professor in Early Modern History at the University of East Anglia and author of Rummage: A History of the Things We Have Reused, Recycled and Refused to Let Go. Laurence Scott is the author of books about digital life including The Four-Dimensional Human and Picnic Comma Lightning. How did such a mundane substance revolutionise modern warfare, enable Imperialism and transform art? Can there ever be a blank page? Is recycling the answer to waste? The conversation ranges across the relationship between paper and religious history in the printing of the Quran and Tibetan rituals for the dead; to C17 Swedish paper bullets; Dickens' Bleak House - in which a pile of paper leads to a fatal fire; the Bristol company who specialised in papier-mâché – a material used for elaborate decorations in C18 homes – and then used by artists like Jean Dubuffet in the 1940s and 50s and a scrap of paper, which survived 9/11 and told a widow, about her husband's final moments. Producer: Jayne Egerton
Dr. Phil Cardoso and Dr. Adam Lock of Michigan State University discuss Dr. Lock's recent study on the effect of supplementing two major fatty acids, palmitic and oleic acid, in different ratios on milk production in high-, medium- and low-producing cows.PaperCast is now available as an audio podcast!Find us on: Apple Podcasts: https://podcasts.apple.com/us/podcast/dairy-focus-papercast/id1530748959Spotify: https://open.spotify.com/show/223Pv4qwRcMFyyy3CXdL3rPodcast Addict: https://podcastaddict.com/podcast/3098543Podchaser: https://www.podchaser.com/podcasts/dairy-focus-papercast-1420022RSS: https://feeds.buzzsprout.com/1327510.rssLinks to papers mentioned in this episode ----------------------------------------------------Western et al. 2020, Milk production responses to altering the dietary ratio of palmitic and oleic acids varies with production level in dairy cows. DOI: https://doi.org/10.3168/jds.2020-18936 https://pubmed.ncbi.nlm.nih.gov/33069410/de Souza et al. 2019, Altering the ratio of dietary C16:0 and cis-9 C18:1 interacts with production level in dairy cows: Effects on production responses and energy partitioning. DOI: 10.3168/jds.2019-16374https://pubmed.ncbi.nlm.nih.gov/31495626/Lock et al. 2006, Concepts of fat and fatty acid digestion in ruminants. https://www.researchgate.net/publication/266499830_Concepts_of_fat_and_fatty_acid_digestion_in_ruminantsBurch et al 2020, Milk production responses of dairy cows to fatty acid supplements with different ratios of palmitic and oleic acid in low- and high-fat basal diets. Abstract #175 in https://www.adsa.org/Portals/0/SiteContent/Docs/Meetings/2020ADSA/ADSA2020_Abstracts.pdf?v20200708.
Pro Ketogenic Bodybuilder Robert Sikes: Getting Lean & Training Using Keto / Ketogenic diet. 02:40 - Lost a lot of muscle used the bro-science method and didn't see good results 03:25 - Eating disorders 04:20 - Relationship with food improved and got pro bodybuilding card using keto 06:35 - How Robert structures his day (overview) 08:00 - Cutting and muscle growth phase 09:50 - Stearic acid and fat loss benefits. Fewer insulin receptors on fat cells 12:05 - Competition prep strategy 14:30 - First meal and training time 16:05 - Second mealtime and sleep quality tips 17:20 - Food macros and more on contest prep 19:30 - Carb refeeds vs fat refeeds for contest prep 22:05 - Length on time for fat to replenish glycogen 24:45 - Adaptation period for becoming keto / fat adapted 30:10 - Your energy and brain functions better and is fueled largely by body fat. 31:40 - Not being fat-adapted paves the way for you to have more energy crashes, cravings, and mood swings 33:35 - More flavour in higher fat foods 34:00 - How to weight train using keto 36:30 - Cardio on keto 39:30 - How to manipulate dietary fats to burn more body fat with the C18:0 fat stearic acid: ------
The Whole View, Episode 461: Oats-M-G, Are These Actually Healthy? Welcome back to episode 461! (0:28) Stacy has mentioned in the past how great she feels when she includes some oats in her diet. She clarified that it's not something she loads up on daily. Finding high-quality, gluten-free, and non-glyphosate was a game-changer for her as well. For years, Stacy and Sarah have talked about how grains were problematic for digestion, proper absorption of nutrients, and gut health. However, it's important to revisit how we look at food with a scientific approach as often as possible. Both Stacy and Sarah's health journeys took a path through the Paleo Diet to a point where they are now very open to experimenting with foods they were not maligned to for a long time. For Sarah, that means revisiting the science of these foods to get away from the idea of grouping foods together and instead look at the pros and cons of individual foods and how they can fit into an overall healthy diet to empower others to experiment. Sarah is a self-described Thrive Market junkie, and many of the (non-sponsored) products she and Stacy will be discussing can be found on their site. They also have a great feature called subscribe and save, where you can save money on products you buy regularly! Listener Question Sarah and Stacy have received many questions on this topic. This question in particular resonated the most: First off, I ADORE you both. I feel like you are my best friends and just don't know it yet :) I want to eat raw heads of lettuce (I've done this for years!) and get angry about poorly conducted research with Sarah, and go lift heavy weights while discussing clean beauty with Stacy. I can't get enough of you guys! So, my question is related to oats. Because my diet has been restrictive for so long while I've tried to heal my digestive system after being diagnosed with celiac three years ago, I have now developed anaphylactic responses to a lot of paleo foods. I was really happy this month when I was successfully able to reintroduce rice and oats, finding them to actually feel calming on my stomach. Because my list of paleo foods that I am reacting to keeps growing longer the more I rely on them, I am finding myself turning to these other foods like legumes, rice, and oats, on a daily basis in order to simply get enough food in. While I seem to tolerate it, it makes me nervous that I may be doing long term damage. I know you have discussed briefly how rice and some beans are actually not bad for the gut, but that was still always with the caveat of them being eaten "occasionally." And I don't think I've heard you discuss oats much at all. Could you perhaps address the effect of GF oats on the microbiome, as well as the overarching effects of a diet that includes a lot of these "non paleo" foods, but in the context of an otherwise veggie and fruit rich diet with only healthy fats, high quality meat and organ meats, and no refined sugars? Thank you! I love you both and am so thankful for all you do! - Anna Dogma of Paleo and Other Rigid Diets Stacy shares how much this question resonates with her. She first started on this health journey from guilt and feeding into the dogma of paleo that glorifies some foods and demonizes others. (8:00) In fact, what qualifies as a "paleo" food will vary from person to person. It's okay to lean into foods that make you feel good even if they don't fit a diet "framework" of what good and bad for you. For example, it was easy for Sarah to lump oats in with wheat and other grains and not critically evaluate it independently. Paleo has a very rigid set of rules, and it's important to Sarah to give listeners the tools and confidence needed to find what works best for them as individuals. Even if you stray from the framework of a particular diet but still identify with the term Paleo, there's nothing wrong with that. What works today might not work two years from now. It's okay to change to something better suited for what we need in a moment. Stacy stresses that they are not here to tell you what good, bad, and qualifies under a certain label. Health Benefits of Oats Oats have been very well studied for at least 30 years and have some well-established health benefits. (16:27) Whole grain oat products have shone to positively impact coronary heart disease, diabetes, satiety/weight management, low glycemic index, and blood pressure. These characteristics are mainly attributed to the high content of oat-specific beta-glucans, which are soluble food fibers. However, some people don't do well with oats. This is likely due to gluten cross-contamination. Gluten is a prolactin that is inflammatory that increases intestinal permeability, and is linked to adiposity signals. But avenin, prolamin type lectin, may not be as bad. Oats are often grouped in with wheat and barley as problematic, but not because oats themselves are a problem. Avenins are present at a lower concentration (10%–15% of total protein content) in oat as compared to gluten in wheat (80%–85%). The avenins in the genus Avena are free of the known CD immunogenic epitopes from wheat, barley, and rye. T cells that recognize avenin-specific epitopes have been found very rarely in CD patients. In fact, avenins are highly digestible and don't come out half-digested like gluten often does. Unlike gliadin peptides, oat peptides are also sensitive to digestion by pepsin, trypsin, and chymotrypsin in the gastrointestinal tract. They are unlikely to have any clinical relevance. Some cultivars of oats are gluten cross-reactors, meaning that if your body forms antibodies against gluten. But this appears to be a fairly low-frequency cross-reactivity and even not a problem for most people with celiac. High Likelihood of Cross Contamination However, oats are often processed on the same wheat, making the potential contamination pretty high. For example, the U.S. specification for No. 1 oats allows the presence of up to 2% foreign material, which could be all wheat and barley! So yes, the biggest con of oats is that it's frequently contaminated with gluten. As we discussed on a recent show, upwards of 55% of people, have at least one gluten sensitivity gene. Stacy references Oat O's and Thrive Market (not sponsored on this show!) for reduced risk of cross-contamination and what she personally leans on. For more information, Sarah recommends: frontiersin.org/articles/10.3389/fped.2019.00384/full tandfonline.com/doi/full/10.3402/fnr.v60.30324 journals.plos.org/plosmedicine/article?id=10.1371/journal.pmed.0010001 Oats Nutrient-Density Although oats fare better than other grains, they are nutritionally underwhelming per calorie. (26:50) A 100-gram (2/3 cup) serving of oats has a moderate glycemic load (37) but serves a fairly high (389) in calories. That serving of oats does provide an impressive 246% DV for manganese and 40-50% DV for vitamin B1, magnesium, and phosphorous. It also provides 20-30% DV of iron, copper, zinc. Not too shabby... but not crazy impressive either. Sarah has been calculating Nutrivore Scores, and oats are the third-highest grain after corn and buckwheat. She adds that this is neither a pro nor a con for oats but shouldn't really be considered a "foundational" part of your diet, but rather fit in for added benefits. Revisit 29:30 to figure out what Stacy is talking about with more context. Oats and the Microbiome That same 100-gram serving contains a whopping 10.6 grams of fiber, including being particularly rich in a very special soluble fiber: mixed linkage beta-glucan. (34:31) This is a highly fermentable fiber that feeds anaerobic microbes in the gut and significantly increases the production of the short-chain fatty acids butyric and propionic acids. Oats contain 3-7% beta-glucan! Studies show over and over again that beta-glucans from oats significantly increase the growth of very important probiotic strains of Bifidobacterium as well as the Lactobacillus-Enterococcus group. And oat beta-glucans seem to be better than beta-glucans from other grains. One study showed that an oat-based diet resulted in higher Bifidobacteria levels than either a barley-based or wheat-based diet supplemented with equivalent amounts of beta-glucan. In addition, these high levels of beta-glucan appear to be the "magic ingredient" behind oat's most famous properties, including their cholesterol-lowering effects. This occurs because beta-glucan increases the viscosity of the chyme in the upper GI tract, leading to increased binding and secretion of bile acids. In turn, plasma cholesterol becomes a substrate for newly formed bile, causing blood levels to decrease. Beta-glucans contribute to the maintenance of normal blood cholesterol levels. Consumption of beta-glucans from oats and barley as part of a meal (4 g/30 g carbohydrates) contributes to reducing the blood glucose rise after that meal (EU 432/2012). Oat grain fiber contributes to an increase in fecal bulk (EU 432/2012). Reducing saturated fat consumption contributes to the maintenance of normal blood cholesterol levels (EU 432/2012). Oat beta-glucan (3 g/day) has been shown to actively lower/reduce blood cholesterol. High cholesterol is a risk factor in the development of coronary heart disease (EU 1160/2011). In addition, oat fibers increase the fecal bulk, which contributes to a normal stool and positively impacts the functioning of the microbiome. Oats in particular also have high bioactive potential and relatively high lipid content relative to other grains. Their unique composition contributes some special benefits to gut health compared to other whole grains. Surprise! Oats Are Super Digestible Protein content in the oat groat is relatively high (15%–20% by weight), as is the digestibility of oat protein (90%), and the majority (85%–90%) of oat protein consists of globulins. (43:15) This is in contrast to wheat, in which the vast majority consists of gluten. Starch (about 60% of the total dry weight) is a major component of the oat grain. The amylopectin: amylose ratio is about 3, and the digestibility of oat starch is about 100%. Oat starch digests slowly, partly due to high amounts of fiber and the high oil content in whole grain oat, which retards stomach emptying and improves digestion. This results in a gradual supply of glucose to the intestine, which maintains a long feeling of satiety. As a result, whole grain oat foods have a low glycemic index (GI), which is advantageous in cases of diabetes and obesity. Compared to other cereals, oat grains have a relatively high oil content of on average 7% oil, but some varieties can have up to 18%: The three most abundant fatty acids are palmitic (C16:0; 20%), oleic (C18:1; 35%), and linoleic (C18:2; 35%) acids, which account for about 90%–95% of the total fatty acids. The largest part is thus unsaturated, but there is more omega-6 than omega-3. Alpha-linolenic acid (18:3, omega-3) is notably present in the oat germ. The high lipid content can also hurt the sensory quality of oat products because of lipid oxidation, which produces fatty acid hydroperoxides and volatile aldehydes, causing rancidity. Therefore, before further processing, oats are kilned—a high-temperature treatment to inactivate especially lipases. So, Which Oats Are Best? Sprouted is best! Sprouting happens the seed is trying to turn itself into a plant. However, they are tough to sprout at home unless you buy unkilned oat groats. (48:35) The nutritional and bioactive properties and key enzymatic activities were studied in sprouted oat powder and compared with those of oat grain powder (control). Sprouted oat powder was an excellent source of protein (10.7%), β-glucan (2.1%), thiamine (687.1 μg/100 g), riboflavin (218.4 μg/100 g), and minerals (P, K, Mg, and Ca). This presented better amino acid and fatty acid compositions and levels of γ-aminobutyric acid (54.9 mg/100 g), free phenolics (507.4 mg GA/100 g), and antioxidant capacity (1744.3 mg TE/100 g) than control. Enhanced protease and α-amylase and reduced lipase activities were observed in sprouted oat powder. Promising features to improve its nutritional, sensorial, and health-promoting properties! Since 2009 (EC 41/2009) and 2013 (FDA), oat products may be sold as gluten-free in several countries provided a gluten contamination level below 20 ppm. Note: 20ppm may still be too high for celiac or gluten allergy! Types of Oats Interestingly, when it comes to oats, the size of the flakes appears to make a difference in how the gut microbiota are affected. One study found that thick oat flakes, but not thin oat flakes, increased Bifidobacterium levels during fermentation while also producing 2.5 times more butyrate than the thin oat flakes. The authors of this study suggested the resistant starch content of the thick oat flakes may explain these differences. Steel-cut oats have a little more resistant starch, slightly higher beta-glucans, and higher total fiber than old-fashioned rolled oats. Remember, old-fashioned rolled oats are better than quick oats. One small study showed slightly higher butyrate production with steel-cut oats than old-fashioned, but it wasn't statistically significant. Sarah recommends One Degree brands for the best-sprouted oats (not sponsored! Just a Sarah-approved favorite). Personally, Stacy and Sarah have both Old Fashion and Steel Cut oats currently in their pantries. Sarah recommends using an instant pot as well! Sarah's ideal recipe is 2 cups steel cut oats, 5-6 Cups of water (depending on how thick you like your porridge), and 1/2 a teaspoon of salt (scale up or down as desires). In Instapot, cook for 4 minutes on high pressure and then let the pressure naturally decline. Add flavoring as needed, such as maple syrup to slightly sweeten. Stacy also recommends trying this pumpkin oatmeal recipe, which has always been a crowd-pleaser. How to Experiment Sarah recommends starting by utilizing a food journal to see if you're reaching your nutrient targets for the day. If you are, first cut out the food from your diet for at least two weeks, even including trace amounts. This ensures you're testing your actual reaction and not the reaction you're currently having while already consuming the food. This helps you isolate and identify. Next, pick a day to challenge when you're feeling good, slept well, not stressed, and not eating anything else out of the ordinary. If you're worried about an allergy response, make sure you go slow since they can get really big very fast. If you check for sensitivity, like mood, stomach, or skin issues, it's okay to go more all-in. If you're not sure if something was a reaction (mild reactions can be tough), give yourself a few days to reset, and then try again to see if you have the same experience. If you're thinking about experimenting with oats, Sarah recommends buying sprouted oats (which reduces anti-nutrient content) that are certified gluten-free. Be sure to follow a methodical reintroduction protocol! Also, oats are way less likely to be tolerated by people with celiac disease (and potentially other autoimmune diseases) or anyone who has tested positive for wheat/gluten or oats on a food allergy/intolerance screen in the past. Final Thoughts Sarah views oats as a "sometimes food" due to the importance of quality. (1:01:30) Stacy's philosophy is all about variety and introducing foods to develop a palate. And the more science we look at, the more we can emphasize foods we know are beneficial to our gut and health overall. It's important not to emphasize "yes" and "no" in terms of food, but instead look at each food as an individual in terms of a healthy diet overall. Identifying your triggers is very important, and knowing that not every food will work for every person. Be sure to head over to Patreon for bonus content on how Stacy and Sarah really feel about this topic and more! Your subscription supports this show and gets your questions first in line. Thank you for your great question, Anna, and thank you, listeners, for joining us! We will see you next week.
As interest in oligonucleotide therapeutics increases, there is an ever-growing need for analytical techniques that can properly analyse and quantitate these complex biomolecules. Mass spectrometry (MS) is required to analyse impurities, degradants, and other biological/chemical modifications and is the method of choice for the analysis of synthetic oligonucleotides. Sixfold Bioscience, in collaboration with the National Measurement Laboratory (NML) have been using the Agilent AdvancedBio 6545XT LC/Q-TOF to develop a method to analyse complex oligonucleotides of various lengths with volatile ion pair reagents. This method is used for quality control of oligonucleotides that are subsequently assembled into Mergos™ for use in in vivo applications. In addition to the analytical capabilities currently being utilised by Sixfold, the Agilent 1290 Infinity II Preparative system is also being used for oligonucleotide purification. Both reverse-phase (C18) and anion-exchange (IEX) chromatography is regularly carried out to assist in Sixfold's purification workflow. As a result of this work, and as an extension to the work currently being carried out by the Tate group at Imperial College, a Metabolomics group is in the process of being formed at the Molecular Sciences Research Hub. This group will aim to solve challenges related to the analysis of biomolecules and will take advantage of the combined know-how and expertise of scientists at Imperial College, Sixfold Bioscience and Agilent. Dr James Rushworth, Research Associate at Sixfold Bioscience. For Research Use Only. Not for use in diagnostic procedures. DE44320.2788078704
Patreon Patreon Contest - What is your favorite indie game? Friend of the Show, Lee Saenz has made a video game called “Triple Jump” https://rebrand.ly/triple-jump-game It’s only $3.37 We’re gonna give away 10 copies, 5 to the first 5 people to respond, and then 5 at the end of the month to the answers we like best We’re streaming with patrons most Thursdays now, so watch out for the message on slack to sign up to be eligible for that week. Ryan - @greenegeek Zack - @z4ck38 Together - @commandersocial You can find us on Twitter https://store.mothershipatx.com SOCIALSHIP - free shipping on orders of $50 or more SOCIAL10 - 10% off in stock MTG singles https://discord.gg/MMXQJqf Thursday nights come play at mothership! Our LGS has setup an online store! @TripleJumpGame1 - 0:57 @TheTokenOtaku - 4:02 @MothershipGames - 7:20, 10:37, 21:01 @realCardsphere - 10:28 @atfloury - 13:44 @BrainstormBrew - 14:36 @MTGStocks - 15:54, 36:01, 53:31, 1:01:36 @commandcast - 17:02, 1:01:17 @JoshLeeKwai - 17:19, 1:01:17 @MTGGoldfish - 19:40 @MTGMoo - 31:29 @Card_Kingdom - 1:01:36 Ep 93 Community Spotlight: We tend to think of 5 years as recent, but we know a lot of our listeners (and Patrons) might be newer to Magic, so we thought it might be fun to go back and look at the past 5 years of Commander Precons. Value (We’re gonna discuss a lot of this below, but let's try and mention the others on this list as well) Disclaimer: The MtG market is in a bit of chaos, things seem way more expensive than they ever have been. (Overmaster is $40!). We certainly aren’t finance experts but both of us follow the Secondary Market pretty regularly. Cool Cards (We talked about this in our previous episode, but it’s still one of the most important pieces to the pre-cons long term) Fun to Play Balanced to play against each other Good enough to hang with your meta’s constructed decks There are lots of ways to evaluate Precons. C21 - Focused on Each College Identity Whole deck, singles price in () Lorehold Legacies - $38.48 (Singles - 102.80) Prismari Performance - $39.25 (Singles - 71.66) Quantum Quandrix - $38.06 (Singles - 86.83) Silverquill Statement - $37.83 (Singles - 83.31) Witherbloom Witchcraft - $37.71 (Singles - 68.48) Bundle of all 5 - $189.04 (Mothership has this for $179.99) I’m gonna do the values of singles in the deck based on mtggoldfish, I did look on ebay, and most of the decks were costing about the same as the cost of the singles, with maybe a slight discount. https://www.mtggoldfish.com/articles/commander-2017-decklists Feline Ferocity - $269.93 Vampiric Bloodlust - $257.06 Draconic Domination - $255.23 Arcane Wizardry - $149.86 C17 - Tribal Theme https://www.mtggoldfish.com/articles/commander-2018-decklists Exquisite Invention - $110.94 Subjective Reality - $90.64 Nature's Vengeance - $120.56 Adaptive Enchantment - $91.01 C18 - Planeswalker Commanders https://www.mtggoldfish.com/articles/weekly-update-aug-11-commander-2019-decklists Faceless Menace - $66.20 Mystic Intellect - $91.57 Primal Genesis - $67.86 Merciless Rage - $46.07 C19 - Each deck focused on a mechanic (Morph, Flashback, Populate, Madness) https://www.mtggoldfish.com/articles/full-commander-2020-decklists Enhanced Evolution - $66.25 Symbiotic Swarm - $45.86 Timeless Wisdom - $87.87 Arcane Maelstrom - $83.67 Ruthless Regiment - $63.41 C20 - Mechanics (Mutate, Cycling, Copy Spells, Token Creatures Buying individual Decks Top 5 Most Expensive Cards from Precons C17 - C21 C17 - - $217.01 Edgar Markov 60.08 All time low $2.39 Spent an entire year < $5 All-time low $12.29 Spent 3 months < $20 Teferi's Protection 44.13 All-time low $2.99 Spent a year < $10 Kindred Discovery 40.7 All-time low $3.23 Spent a year < $6 The Ur-Dragon 39.65 All-time low $1.49 Spent a year < $7 Kindred Dominance 32.45 Nesting Dragon 17.42 Retrofitter Foundry 16.41 Treasure Nabber 14.28 Xantcha, Sleeper Agent 13.87 Sower of Discord 11.9 C18 - $73.88 Dockside Extortionist 48.22 All-time low - $13.28 Quickly went to $20, and after 8 months just kept going up Ohran Frostfang 17.92 K'rrik, Son of Yawgmoth 5.1 Sevinne's Reclamation 4.36 Apex Altisaur 3.18 C19 - $78.78 Fierce Guardianship 34.43 All-time low - $29.97 All-time high - $80.24, relatively flat aside from that early spike, that lasted roughly a month All-time low - $14.78 Stayed under $20 for 7 months, and then spiked Deflecting Swat 30.1 Deadly Rollick 15.58 Flawless Maneuver 8.3 Ethereal Forager 4.07 C20 - $92.48 Archaeomancer's Map 19.63 Veyran, Voice of Duality 16.96 Adrix and Nev, Twincasters 13.8 Monologue Tax 13.25 Esix, Fractal Bloom 8.61 C21 - $59.00 For all of the individual cards it might be fun to look at the price graphs on https://www.mtgstocks.com/ (I looked at all the graphs for cards currently valued at $30 or more) Summary - What has been your favorite set of Precon Decks? How do you think this year's offering stacks up to previous years? Did you like this kind of episode? Were we too heavy on the finance stuff? Main Topic - Precon Showdown Keep it Social! Komiku - Battle of Pogs https://creativecommons.org/publicdomain/zero/1.0/ Zack Gets it Together Theme Consider becoming a Patron: https://www.patreon.com/commandersocial You can check us out at commandersocial.com YouTube - https://www.youtube.com/CommanderSocial You can email us directly at cast@commandersocial.com Instagram: https://www.instagram.com/commandersocial On twitter @commandersocial twitch.tv/greenegeek Ryan individually @greenegeek Zack individually @z4ck38 Contact Info © Copyright 2021 Leaky Dinghy, LLC
第11章 神過去未來現在的工作，提醒守主誡命 1-9 訴說神過去的工作，提醒這世代 →A1-5 神的恩典拯救 →B6 神的公義審判 →C 7-9 提醒要守神誡命 10-21 神將要做的工作 →A10-15 憐憫拯救，豐盛恩典應許之地 →B16-17 神對不守誡命的審判 →C18-21 提醒要守神誡命，每一處都要有神的話 22-32 神現在要做的工作 →A22-27 遵守神命令的福氣 →B28 不聽神命令而遭禍 →C29-32 提醒要守神誡命，將祝福與咒詛放在兩個山中：基利心山，以巴路山 結構大綱：這章提醒以色列人神過去1-9；未來10-21；現在22-32；而經文的結構都是A神的恩典福氣；B神公義的審判，C提醒要守神的誡命！很濃縮的回顧了過去神帶領出埃及，未來即將要帶領百姓進入應許地；現在要趕逐出迦南人；而也不斷強調神的公義刑罰審判，在神的恩典與真理，憐憫與公義中，我們應當對神的回應就是謹守神的誡命，把神的話放在心內，手上，額上，口中，門上，基利心山，為要使我們謹守！ 鑰節：11:1 你要愛耶和華你的神，常守他的吩咐、律例、典章、誡命。 11:1,13,22 連續三遍強調愛與順服，而次序是先愛再順服！愛才能帶來順服！神用祂自己的生命與愛向我們傾倒，使我們要得著全新的生命！而我們蒙恩的人，應當在愛神中大力回應祂的話！ －－－－－－－－－－－－－－－－ 講員： 貴格會合一堂 徐坤靖牧師 聖經之鑰-各卷書播放清單： https://thfc.pse.is/3epsdf 【聖經之鑰 相關資源】 YouTube： https://thfc.pse.is/3cfams 電子書： https://thfc.pse.is/3ccluu Powered by Firstory Hosting
第 23 章 化咒詛為祝福 22:39-23:12 第一次預言－基烈胡瑣 →A41-3 築壇獻祭 →B4-6 神與巴蘭的對話 →C7-10 巴蘭的預言：化咒詛為祝福，神不咒詛，人數極多 →D11-12 巴勒氣憤 13-26 第二次預言－鎖腓田 →A13-15 築壇獻祭 →B16-17 神與巴蘭的對話 →C18-24 巴蘭的預言：神定意賜福，沒有法術可傷害雅各，如獅勇猛 →D25-26 巴勒氣憤 27-24:13 第三次預言－比珥山頂 →A27-30 築壇獻祭 →B1-2 神與巴蘭的對話：聖靈感動 →C3-9 巴蘭的預言：以色列的榮美，復興，得勝 →D10-13 巴勒氣憤 24:14-25 第四次預言－ →14-19 以色列未來的復興得勝：得勝之星 →20-22 亞瑪力，基尼人必沉淪 →23-25 亞述希伯的被擄受苦 結構亮光：巴勒帶著巴蘭三次在不同地點要咒詛以色列，但是神都化咒詛為祝福，為得勝的宣告！三次的結構都相同：築壇獻祭，神對巴蘭說話，巴蘭的預言，巴勒氣憤！比較四次預言，第一段7-10神不咒詛，人數極多；第二段18-24神定意賜福，沒有法術可傷害雅各，如獅勇猛；第三段24:3-9以色列的榮美，復興，得勝；第四段14-19以色列未來的復興得勝！神的祝福再再增加，從人數到軍事，保護到榮美，將來極大的復興，仇敵要攻擊的越大，神的祝福也越大！ 鑰節：23:23 斷沒有法術可以害雅各，也沒有占卜可以害以色列。現在必有人論及雅各，就是論及以色列說，神為他行了何等的大事！ 巴勒要用巴蘭的法術來咒詛以色列，但是神用祂權能的命令來保護以色列，沒有任何的占卜可以傷害，並且相對的，神更為我們行大事，有加倍的福氣要賜給我們！ 感謝主！在神的保護中，沒有任何的邪靈惡者可以攻擊我們！ －－－－－－－－－－－－－－－－ 講員： 貴格會合一堂 徐坤靖牧師 聖經之鑰-各卷書播放清單： https://thfc.pse.is/3epsdf 【聖經之鑰 相關資源】 YouTube： https://thfc.pse.is/3cfams 電子書： https://thfc.pse.is/3ccluu Powered by Firstory Hosting
第8章 第二三四災：蛙虱蠅 1-15 第二災－青蛙－杖伸江河青蛙上 A1-4 神的吩咐 B5-6 摩西亞倫順服遵行 C7-15 法老的回應 7 法術者也能行 8 法老答應可離開 9-14 摩西禱告隔天青蛙死亡 15 法老反悔拒絕！ 16-19 第三災－虱子－塵土變虱子 A16 神的吩咐－杖擊塵土變虱子 B17 摩西順服 C18-19 法術者無能，認明這是神的工作，法老拒絕 20-32 第四災－蒼蠅 A20-24 神吩咐－成群蒼蠅臨到，但神的子民被分別出來！ C25-32 法老與摩西對話： a25法老：在這地祭祀神 b26-27摩西：9 埃及人厭惡，要道曠野，照神吩咐而行 a28法老：可以去，不要走太遠，為我祈禱 b29-31摩西：明日蒼蠅離開 a32 法老：硬心反悔 結構亮光：請比較行法術者的態度有何改變？法老態度有何改變？ 前兩災，法術者也能行，到了第三災，18行法術者不能行而認出是神的工作！地上一切欺騙的力量在真神面前站立不住！ 法老第二災答應後，15當災難減輕時，又反悔；第四災後再次答應，32災難過去後又反悔！ 人拒絕神、抵擋神將成為一種習慣，不自覺、無法控制的反對神！ 鑰節：23 我要將我的百姓和你的百姓分別出來，明天必有這神蹟。』 神在這些的神蹟與災難中，要做一個「分別」的動作，要把神的選民與世界區別開來！這個分開也有救贖之意！ 在蒼蠅之災中被分別出來，在世界的潮流價值中分別出來！在末日的審判中分別出來！ 8:22 當那日，我必分別我百姓所住的歌珊地，使那裏沒有成群的蒼蠅，好叫你知道我是天下的耶和華。 8:23 我要將我的百姓和你的百姓分別出來，明天必有這神蹟。』」 8:28 法老說：「我容你們去，在曠野祭祀耶和華你們的神，只是不要走得很遠。求你們為我祈禱。」 8:29 摩西說：「我要出去求耶和華，使成群的蒼蠅明天離開法老，和法老的臣僕並法老的百姓，法老卻不可再行詭詐，不容百姓去祭祀耶和華。」 －－－－－－－－－－－－－－－－ 講員： 貴格會合一堂 徐坤靖牧師 聖經之鑰-各卷書播放清單： https://thfc.pse.is/3epsdf 【聖經之鑰 相關資源】 YouTube： https://thfc.pse.is/3cfams 電子書： https://thfc.pse.is/3ccluu Powered by Firstory Hosting
第1章 在埃及受苦中昌盛 1:1-7 以色列在埃及昌盛 1-5 雅各下埃及70人 6-7 約瑟死後，後代極其強盛 8-14 在埃及受苦 8-10 新王興起，懼怕以色列人而逼迫 11-14 強逼做苦工， 12越發增多 15-22 收生婆敬畏主，為以色列人存留 A15-16 法老吩咐殺以色列男孩 B 17 收生婆敬畏神，存留男孩 C18-20 收生婆回答法老，以色列人極其強盛 B 21 收生婆敬畏神，建立家室 A22 法老吩咐殺以色列男孩 結構亮光：1-7 以色列昌盛，8-14 在埃及受苦，15-22 以色列在生產危機中昌盛，最大的危機中卻得著昌盛！ 鑰節：17 但是收生婆敬畏 神，不照埃及王的吩咐行，竟存留男孩的性命。 對神的敬畏遠超過對王的懼怕！微小的收生婆名字卻被記錄在聖經中，並且加入神救贖的計劃！神為她們建立家室！ 以色列在埃及面對極大的危機：政治勢力式微8，政治逼迫10，經濟重擔11-14，對男丁的暗殺令15-16，22！但是神給他們極大的恩典：7,12,20人口極其昌盛！越逼迫，越榮耀！這樣的苦難有個更重要的意義在後面：讓以色列人學習呼求神，並且在苦難中可以出埃及，進入應許地，若沒有這樣的苦難，很可能這群以色列人並不願意離開當時文化大國埃及！每個苦難背後有更超越上帝的智慧與祝福！ 在最大的逼迫中，神興起微小卻重要的幫助者：收生婆！因著對神的敬畏，不怕王怒，保存性命，神為她們建立家室！甚至她們的名字被記錄在聖經中，何等的榮耀！ 1:15 有希伯來的兩個收生婆，一名施弗拉，一名普阿；埃及王對她們說： 1:16 「你們為希伯來婦人收生，看她們臨盆的時候，若是男孩，就把他殺了；若是女孩，就留她存活。」 1:18 埃及王召了收生婆來，說：「你們為甚麼作這事，存留男孩的性命呢？」 1:19 收生婆對法老說：「因為希伯來婦人與埃及婦人不同，希伯來婦人本是健壯的（原文是活潑的），收生婆還沒有到，她們已經生產了。」 1:20 神厚待收生婆。以色列人多起來，極其強盛。 1:21 收生婆因為敬畏神，神便叫她們成立家室。 1:22 法老吩咐他的眾民說：「以色列人所生的男孩，你們都要丟在河裏，一切的女孩，你們要存留她的性命。」 －－－－－－－－－－－－－－－－ 講員： 貴格會合一堂 徐坤靖牧師 聖經之鑰-各卷書播放清單： https://thfc.pse.is/3epsdf 【聖經之鑰 相關資源】 YouTube： https://thfc.pse.is/3cfams 電子書： https://thfc.pse.is/3ccluu Powered by Firstory Hosting
On this episode, Maddie Bogart, OA director at CP, comes on the show to tell us about her time at camp. A true camp veteran, she's seen a thing or two and has formed countless memories for herself and her campers. Topics: -basketball phenom -pamper pole -C18 fakeout -OA cult -rope burn -white illusion -Maddie and her girls
First Nations composers share stories and visions. And make new music for an C18 square piano, voice, violin, and didgeridoo.
First Nations composers share stories and visions. And make new music for an C18 square piano, voice, violin, and didgeridoo.
Link to bioRxiv paper: http://biorxiv.org/cgi/content/short/2020.10.12.336412v1?rss=1 Authors: Zhen, Y., Ewert, K. K., Fisher, W. S., Steffes, V. M., Li, Y., Safinya, C. R. Abstract: Lipid-based carriers of the hydrophobic drug paclitaxel (PTX) are used in clinical trials as next-generation agents for cancer chemotherapy. Improving the loading capacity of these carriers requires enhanced PTX solubilization. We compared the solubility of PTX in cationic liposomes (CLs) with lipid tails containing one (oleoyl; C18:1 {Delta}9 DOTAP/DOPC) or two (linoleoyl; C18:2 {Delta}9 DLinTAP/DLinPC) cis double bonds with newly synthesized cationic DLinTAP (2,3-dilinoleoyloxy-propyl-trimethyl-ammonium methylsufate). We used differential-interference-contrast microscopy to directly observe PTX crystal formation and generate kinetic phase diagrams representing the time-dependence of PTX solubility as a function of PTX content in the membrane. Replacing tails bearing one cis double bond (DO lipids) with those bearing two (DLin lipids) significantly increased PTX membrane solubility in CLs. Remarkably, 8 mol% PTX in DLinTAP/DLinPC CLs remained soluble for approximately as long as 3 mol% PTX (the membrane solubility limit which has been the focus of most previous fundamental studies and clinical trials) in DOTAP/DOPC CLs. The large increase in solubility is likely caused by enhanced molecular affinity between lipid tails and PTX upon replacement of oleoyl by linoleoyl tails, rather than by the transition in membrane structure from lipid bilayers to inverse cylindrical micelles observed in small-angle X-ray scattering. Importantly, the efficacy of PTX-loaded CLs against human prostate cancer (PC3) cells from measurements of the IC50 of PTX cytotoxicity was unaffected by changing the lipid tails, and toxicity of the CL carrier alone was negligible. Moreover, efficacy was approximately doubled against human melanoma (M21) cells for PTX-loaded DLinTAP/DLinPC over DOTAP/DOPC CLs. The findings demonstrate the potential of chemical modifications of the lipid tails to increase the PTX membrane loading well over the typically used 3 mol% while maintaining (and in some cases even increasing) the efficacy of CLs. The increased PTX solubility will aid the development of liposomal PTX carriers that require significantly less lipid to deliver a given amount of PTX, reducing side effects and costs. Copy rights belong to original authors. Visit the link for more info
Tucker Goodrich is a Wall Street tech guru and citizen scientist who healed his own illnesses mainly by cutting out vegetable oils and gluten from his diet. He's been on the podcast twice before. We talk about: Imperial College model (no tree grows to heaven) Diamond Princess John Ionnaidis paper Tucker's post for Italy data ARDS soybean oil paper SARS cell change post infection - increases metabolism of w6 fats Serum w6 means more ARDS Malcolm Kendrick Some references: "COVID-19: Is Italy — and Mass Quarantine — "Flattening the Curve" or Riding the Trend?" http://yelling-stop.blogspot.com/2020/04/covid-19-is-italy-and-mass-quarantine.html 1. Plurad D, Green D, Inaba K, Belzberg H, Demetriades D, Rhee P. A 6-year review of total parenteral nutrition use and association with late-onset acute respiratory distress syndrome among ventilated trauma victims. Injury. 2009;40(5):511-515. doi:10.1016/j.injury.2008.07.025 "The incidence of late ARDS among those exposed to TPN was 28.7% (116/404) compared with 3.9% (76/1942) among those not so exposed. Adjustments for potential confounding associated risk factors were made." "For instance, metabolism of omega-3 fatty acids leads to less inflammation than metabolism of omega-6 fatty acids and may reduce the harmful side effects of TPN" 2. Quinlan GJ, Lamb NJ, Evans TW, Gutteridge JMC. Plasma fatty acid changes and increased lipid peroxidation in patients with adult respiratory distress syndrome. Read Online: Critical Care Medicine | Society of Critical Care Medicine. 1996;24(2):241–246. https://journals.lww.com/ccmjournal/Abstract/1996/02000/Plasma_fatty_acid_changes_and_increased_lipid.10.aspx. Accessed April 5, 2020. "As plasma linoleic acid concentrations decreased, there was usually an increase in plasma 4-hydroxy-2-nonenal values, one of its specific peroxidation products, suggestive of severe oxidative stress leading to molecular damage to lipids." 3. Bursten SL, Federighi DA, Parsons PE, et al. An increase in serum C18 unsaturated free fatty acids as a predictor of the development of acute respiratory distress syndrome. Read Online: Critical Care Medicine | Society of Critical Care Medicine. 1996;24(7):1129–1136. doi:10.1097/00003246-199607000-00011 "Increases in unsaturated serum acyl chain ratios differentiate between healthy and seriously ill patients, and identify those patients likely to develop ARDS. Thus, the serum acyl ratio may not only prospectively identify and facilitate the assessment of new treatments in patients at highest risk for developing ARDS, but may also lead to new insights about the pathogenesis of ARDS." Tucker can be found at: Twitter - https://twitter.com/tuckergoodrich Blog - http://yelling-stop.blogspot.com/ Ally can be found at: Twitter - https://twitter.com/paleocanteen Twitter - https://twitter.com/paleoally Instagram - https://www.instagram.com/paleocanteen YouTube - https://www.youtube.com/c/AllyHouston
Ellis is on "sabbatical," so Brynn and Cris go slightly wild with the first in a series of C18/early C19 novels, Sense and Sensibility by the inimitable Jane Austen. We drink our first Totally Made Up Cocktail, discuss class inequality, and wonder if all the men in this novel are trash. Spoiler alert: probably. This episode is brought to you by too many feelings, #firstworldproblems, and ignoring your kid sister. --- Support this podcast: https://anchor.fm/ph-drunk/support
I drink oodles of extra virgin olive oil. Every day. My kids and wife do too. It's a crucial staple in our diet...yet there's plenty of confusion around olive oil... Can you cook with olive oil? How should you store olive oil? What should you look for in a good olive oil? How do you differentiate between all the different certificates and grades of olive oil? And much more! So in today's podcast, I interview T. J. Robinson, aka "The Olive Oil Hunter ®" who is one of the world's most respected authorities on all matters olive oil. Known for his “platinum palate,” he is one of the few Americans invited to serve as a judge in prestigious Italian olive oil tasting competitions. These days he is dedicated to importing rare fresh-pressed olive oil via , the most flavorful and healthiest extra virgin olive oil on the planet, until now virtually impossible to obtain year-round in the U.S. All his oils are independently lab tested and certified for 100% purity. During our discussion, you'll discover: -What makes olive oil so efficacious to our health...5:13 Olive oil leads to a distinct drop in blood pressure w/ no change in cholesterol; increased triglyceride, decreased HDL count (atherogenic index) Bigger predictor of C/V disease is the HDL to triglyceride ratio (more so than total LDL cholesterol) Research on mental health and depression Stabilization of blood glucose w/ small amounts of olive oil throughout the day Rheumatoid arthritis Mediterranean diet associated w/ improvements in longevity (not the modern bastardized version) Fasting Sprouting, fermenting, etc. The primary fatty acid in olive oil is oleic acid (C18:1) It's a double bond (less oxidation); safe for cooking at high temperatures Two fatty acids for the brain: Oleic acid, and fish oil (sardines, mackerel, salmon, herring) Other bioactive compounds: Bi0phenyls (found in the olive fruit that scavenges free radical species) (author of Eat to Beat Disease) Oleocanthol has the same anti-inflammatory pathways as ibuprofen (sans the gastric side effects) Phytosterols Squalines (extra virgin olive oil has high amounts) to protect the skin Alphatocopherols (Vitamin E) Hydroxy turpenic acids (lowers inflammation, risk of cancer, decreases blood pressure) -How T.J. Robinson became acquainted w/ the olive oil mafia...20:18 Grew up in Asheville, NC Scored a gig w/ the Food Network; was sent on assignment to Sicily, Italy, where he became acquainted w/ olive oil Harvest of the olive fruit is celebrated widely in Italy and Greece New Yorker article: by Tom Mueller, author of the aforementioned New Yorker article Rampant fraud: It is easy to package cheaper, lesser quality oils as olive oil and sell at olive oil prices Olive oil sold in bulk is far more susceptible to adulteration than an artisan oil Polyphenols and antioxidants deplete by up to 50% during the first 6 months after distribution -What you need to know about the dates on the package, and how to store your olive oil...33:52 Three killers of olive oil: light, time, temperature Look for the "harvest date" rather than the expiration date Look for dark plastic or glass bottles Don't store olive oil above the stove or in the fridge Store in a pantry at room temperature, away from light Polyphenols and antioxidants prevent the olive oil from oxidizing Restaurant olive oils are often adulterated w/ GMO's, soy, etc. Spirulina and glycine protect the gut from oxidized oils Ben discusses this in his book, Olive oil has similar fat makeup as human breast milk Olive oil is used as a delivery mechanism for food to babies -How olive oil is actually produced...44:07 Olives are picked from the tree, contain 10% oil when they're green Deleafed and washed at the mill Crusher (like a food processor) turns it into a paste Goes into the millaxer (paste begins to break into parts: solid, water, oil) Oil is spun via centrifuge, then goes into the tasting cup The solids are dried out and reused as organic fertilizer for the crops -The process by which T.J. inspects and selects the olives he uses for his customers...51:08 (website is written in Italian) (2019 edition) Samples are collected, big tasting party Identify the farms to visit (5-6) Trees that are stressed (less water) produce a higher quality oil, higher polyphenols Developing relationships: A farm that's not the right fit at a particular season may be in the future Two criteria for extra virgin olive oil: Meet a chemistry panel for quality parameters Panel of tasters looking for taste defects Most oil in the U.S. doesn't go through this tasting panel Oils labeled as extra virgin may not pass the criteria by the time it's purchased -How you can assess (and enjoy) olive oil on your own...1:00:51 "Single variety" refers to one olive fruit used Watch out for oils that are labeled as "blends" Color of the oil isn't necessarily an indicator of its quality Smell the oil Swirl the cup (to release the aromas) The taste test: Fruitiness (flavorfulness) Bitterness (high in polyphenols) Spiciness People are using olive oil as a tool for weight loss It's great as a skin, hair and face moisturizer Can be used as protectant from the sun and skin healer Used to clean tile Drizzle fresh pressed olive oil over vanilla ice cream for dessert -How to cook w/ extra virgin olive oil...1:23:27 If you cook w/ a subpar product, you get a subpar result Article: Purchase small amounts Don't use olive oil that is older than one year from the harvest date -And much more... Resources from this episode: - - , Ben's newest book - Article: - Article: - Article: - - New Yorker article: - by Tom Mueller, author of the aforementioned New Yorker article - (website is written in Italian) - (2019 edition) - (author of Eat to Beat Disease) Episode sponsors: -: Bounce back faster than ever with Kion’s recovery supplement trifecta by supporting muscle protein synthesis, recovery and the body’s healthy response to exercise-related inflammation. BGF listeners, receive a 20% discount from anything at Kion when you use discount code: BGF20. -: A new take on an ancient secret: Pain-soothing herbs, incredible antioxidants, and phytonutrients all in one delicious, soothing “Golden Milk” nighttime tea! Receive a 20% discount on your entire order when you use discount code: BENG20. -: Are you ready for upgraded digestion? Take your body to the ultimate edge of human potential and become biologically optimized with Gluten Guardian. Save an additional 10% off your entire order when you use discount code: GREENFIELD -: You can be sure that I researched all the saunas before I bought mine and Clearlight was the one that stood out from all the rest because of their EMF and ELF Shielding and their Lifetime Warranty. Use discount code: BENGREENFIELD to get $500 off your sauna and a free bonus gift! Do you have questions, thoughts or feedback for TJ or me? Leave your comments below and one of us will reply!
Karis Stephen, C18, is a Fulbright Award Recipient working as an English Teaching Assistant in Malaysia. In addition to pursuing her dream of becoming a legal advocate for underrepresented children, she always finds ways to create music. Her song "All Mine"-- a collaboration between Sense and her former moniker, Eleven-- has over 5 million streams on Spotify to date. Tune in to hear about Karis's impactful adventures abroad and its influence on her future.
New Generation Thinker Sarah Goldsmith's Essay introduces an audience at York Festival of Ideas to Beau Brummel and others who have understood the mixed messages of suits through time. England football coach Gareth Southgate's pitch-side waistcoats and 007's exquisite collection of Tom Ford suits all make one thing clear: sweatpants are out and the formal man's suit, along with its tailor, has triumphantly returned. From the colourful flamboyances of the eighteenth century to the dandy dictates of Beau Brummell and into the inky black 'Great Renunciation' of the nineteenth century, join Sarah Goldsmith for a whirlwind tour of the origins of the most ubiquitous, enduring item of male sartorial fashion and the 'second skin' of the male body, the three-piece suit. Sarah Goldsmith is a historian of masculinity, the body and travel. She is a Leverhulme Research Fellow at the University of Leicester, an AHRC/BBC 2018 New Generation Thinker and a life-long rugby fan. Her first book, Masculinity and Danger on the Eighteenth-Century Grand Tour, is being published in 2019. Sarah Goldsmith on the C18 craze for weightlifting https://www.bbc.co.uk/programmes/m00040wg Sarah Goldsmith discusses the body past and present on Free Thinking https://www.bbc.co.uk/programmes/b0b7my7k Producer: Jacqueline Smith
New Generation Thinker Sarah Goldsmith's Essay introduces an audience at York Festival of Ideasto Beau Brummel and others who have understood the mixed messages of suits through time. England football coach Gareth Southgate's pitch-side waistcoats and 007's exquisite collection of Tom Ford suits all make one thing clear: sweatpants are out and the formal man's suit, along with its tailor, has triumphantly returned. From the colourful flamboyances of the eighteenth century to the dandy dictates of Beau Brummell and into the inky black 'Great Renunciation' of the nineteenth century, join Sarah Goldsmith for a whirlwind tour of the origins of the most ubiquitous, enduring item of male sartorial fashion and the 'second skin' of the male body, the three-piece suit. Sarah Goldsmith is a historian of masculinity, the body and travel. She is a Leverhulme Research Fellow at the University of Leicester, an AHRC/BBC 2018 New Generation Thinker and a life-long rugby fan. Her first book, Masculinity and Danger on the Eighteenth-Century Grand Tour, is being published in 2019. Sarah Goldsmith on the C18 craze for weightlifting https://www.bbc.co.uk/programmes/m00040wg Sarah Golsmith discusses the body past and present on Free Thinking https://www.bbc.co.uk/programmes/b0b7my7k Producer: Jacqueline Smith
New Generation Thinker Alun Withey on what made 18th-century men shave off centuries of manly growth. Recorded before an audience at the York Festival of Ideas. You can hear audience questions from the event as an episode of the BBC Arts&Ideas podcast. To be clean-shaven was the mark of a C18 gentleman, beard-wearing marked out the rough rustic. For the first time, men were beginning to shave themselves instead of visiting the barber, and a whole new market emerged to cater for rising demand in all sorts of shaving products - soaps, pastes and powders. But the way these were promoted suggests there was confusion over exactly what the ideal man should be. On the one hand, razor makers appealed to masculine characteristics like hardness, control and temper in their advertisements whilst perfumers and other manufacturers of shaving soaps, stressed softness, ease and luxury. So enter the world of Georgian personal grooming to discover the 18th century's inner man. Alun Withey lectures in the Centre for Medical History at the University of Exeter and is a Wellcome Research Fellow and a BBC/AHRC New Generation Thinker. He has edited an essay collection on the history of facial hair (Palgrave), curated a photographic exhibition of Victorian beards in the Florence Nightingale Museum in London and has written for BBC History Magazine and History Today. He blogs at dralun.wordpress.com Alun Withey on C16 medical history https://www.bbc.co.uk/programmes/p022kyp1 Alun Withey visits Bamburgh Castle https://www.bbc.co.uk/programmes/p036l4q0 Alun Withey's article about the C19th attitude towards beards https://www.bbc.co.uk/programmes/articles/31SKHd61RYxJBryrQ4NfmWJ/nine-reasons-victorians-thought-men-were-better-with-beards Producer: Jacqueline Smith.
New Generation Thinker Alun Withey on what made 18th-century men shave off centuries of manly growth. Recorded before an audience at the York Festival of Ideas. You can hear audience questions from the event as an episode of the BBC Arts&Ideas podcast. To be clean-shaven was the mark of a C18 gentleman, beard-wearing marked out the rough rustic. For the first time, men were beginning to shave themselves instead of visiting the barber, and a whole new market emerged to cater for rising demand in all sorts of shaving products - soaps, pastes and powders. But the way these were promoted suggests there was confusion over exactly what the ideal man should be. On the one hand, razor makers appealed to masculine characteristics like hardness, control and temper in their advertisements whilst perfumers and other manufacturers of shaving soaps, stressed softness, ease and luxury. So enter the world of Georgian personal grooming to discover the 18th century's inner man. Alun Withey lectures in the Centre for Medical History at the University of Exeter and is a Wellcome Research Fellow and a BBC/AHRC New Generation Thinker. He has edited an essay collection on the history of facial hair (Palgrave), curated a photographic exhibition of Victorian beards in the Florence Nightingale Museum in London and has written for BBC History Magazine and History Today. He blogs at dralun.wordpress.com Alun Withey on C16 medical history https://www.bbc.co.uk/programmes/p022kyp1 Alun Withey visits Bamburgh Castle https://www.bbc.co.uk/programmes/p036l4q0 Alun Withey's article about the C19th attitude towards beards https://www.bbc.co.uk/programmes/articles/31SKHd61RYxJBryrQ4NfmWJ/nine-reasons-victorians-thought-men-were-better-with-beards Producer: Jacqueline Smith.
Twenty years on, HOPE not hate Chief Executive Nick Lowles reflects on the co-ordinated nail bombings by neo-Nazi David Copeland, the similarities between people caught up in extremism then and today, and the police failure to take far-right terrorism seriously.
In deel 1 van hun terugblik op het Magicjaar bespreken Jeroen, Dave en Arjan de belangrijkste sets die in 2018 uitkwamen. In chronologische volgorde waren dat: Rivals of Ixalan (RIX), Masters 25 (A25), Dominaria (DOM), Battlebond (BBD), Core Set 2019 (M19), Commander 2018 (C18), Guilds of Ravnica (GRN) en Ultimate Masters (UMA). Wat waren noemenswaardige kaarten en welke rapportcijfers verdienen de sets?Beluister ook deel 2 van Studio Magics Flashback 2018 (aflevering 22) voor bespiegelingen over banlist announcements, andere noemenswaardige Magicgebeurtenissen, top 3-lijstjes, een vooruitblik op 2019 en goede voornemens!TijdschemaRivals of Ixalan 0:00:57Masters 25 0:12:17Dominaria 0:18:57Battlebond 0:33:54Core Set 2019 0:40:51Commander 2018 0:59:51Guilds of Ravnica 1:08:20Ultimate Masters 1:25:01SocialLike Studio Magic op Facebook: @studiomagicnlVolg Studio Magic op Twitter: @studiomagicnlCreditsPresentatie: Jeroen Koster, Arjan Ang en Dave WeijgertseMontage: Jeroen KosterMuziek: Surf Shimmy - Kevin MacLeod (incompetech.com). Licensed under Creative Commons: By Attribution 3.0 License.
This week we take a classic commander and give them a bit of a different spin. It's Karador Ghost Chieftain and Abzan Lands. This is our take on what could have/should have been the lands-matters precon from C18. Hey we even make up our own Planeswalker commander!Check out the decklist here: https://tappedout.net/mtg-decks/karador-lands-matter/?cb=1542653890Go to www.patreon.com/commandersbrew if you'd like to donate to the podcast and get all the cool perks!Head on over to www.wizardtower.com for all your Magic needs! Great prices on singles and free shipping on cards within Canada if you spend $15 or more! Plus if you use our coupon code, cityofbrews, you'll get 5% off any order over $15!Visit www.commandersbrew.com for direct downloads and a streaming version of the podcast.Like our kind of humour? Check out our Brews News comedy playlist on YouTube for real inside jokes for Magic players! https://www.youtube.com/playlist?list=PLLjcRrl68PLwQSmjTIRztlZNvIQWZSxlXFollow us on twitter at @commandersbrew and individually we are @seantabares and @andyhullbone."There It Is"Kevin MacLeod (incompetech.com)Licensed under Creative Commons: By Attribution 3.0http://creativecommons.org/licenses/by/3.0
Hello and welcome to another episode of Commander Cookout Podcast! This week on CCOPodcast, the boys go way back in time to the inaugural commander pre-cons and take a look at Riku of Two Reflections. Peep the list here: http://tappedout.net/mtg-decks/reflections-of-riku/?cb=1536093716 If you'd like to tell us how we did with the tune up, you can do so by emailing cpmmandercookout@gmail.com or getting after us on Twitter @CCOPodcast or @CCOBrando If you'd like to support the show, beyond just listening, you can do so here: https://www.Patreon.com/CCOPodcast/ Remember that we're only one patron away from reaching our next stretch goal of additional content on YouTube.com and CommanderCookout.com, tell a friend about the show or give us a share on whatever social media format you like the best. Speaking of social media, get onto https://www.facebook.com/CCOPodcast/ or CommanderCookout.com for all the latest details on how to get entered into or C18 giveaway. Share, like, subscribe, retweet (etc.) us on social media and you could win a Commander 2018 sealed pre-con of your choice! Now, Hit our Theme Song!
We round out our C18 re-brew series with Tawnos! Andy puts together a fun Superfriends list where we turn planeswalkers into artifacts and double up their abilities! Plus plenty of other, regular artifact shenanigans!Check out the decklist here: http://tappedout.net/mtg-decks/tawnos-superfriends/?cb=1535480720Go to www.patreon.com/commandersbrew if you'd like to donate to the podcast and get all the cool perks!Head on over to www.wizardtower.com for all your Magic needs! Great prices on singles and free shipping on cards within Canada if you spend $15 or more! Plus if you use our coupon code, summerofbrews, you'll get 5% off any order over $15!Visit www.commandersbrew.com for direct downloads and a streaming version of the podcast.Like our kind of humour? Check out our Brews News comedy playlist on YouTube for real inside jokes for Magic players! https://www.youtube.com/playlist?list=PLLjcRrl68PLwQSmjTIRztlZNvIQWZSxlXFollow us on twitter at @commandersbrew and individually we are @seantabares and @andyhullbone."There It Is"Kevin MacLeod (incompetech.com)Licensed under Creative Commons: By Attribution 3.0http://creativecommons.org/licenses/by/3.0
Lack of reprints. Unfocused deck design. Low power level. These are some of the criticisms that have been aimed at Commander 2018. On this episode of the podcast, Josh and DJ take an in-depth look at this year’s precon decks and break down whether they think C18 is a success or failure. Learn more about your ad choices. Visit megaphone.fm/adchoices
Our third take on the C18 decks has Sean brewing a deck around the new planeswalker commander Estrid, the Masked! Check out the neat moves and weird new enchantment cards we discovered!Check out the decklist here: http://tappedout.net/mtg-decks/estrid-the-stompy/?cb=1534777333Go to www.patreon.com/commandersbrew if you'd like to donate to the podcast and get all the cool perks!Head on over to www.wizardtower.com for all your Magic needs! Great prices on singles and free shipping on cards within Canada if you spend $15 or more! Plus if you use our coupon code, summerofbrews, you'll get 5% off any order over $15!Visit www.commandersbrew.com for direct downloads and a streaming version of the podcast.Check out the decks we've brewed on tappedout.net:http://tappedout.net/users/commandersbrewFollow us on twitter at @commandersbrew and individually we are @seantabares and @andyhullbone."There It Is"Kevin MacLeod (incompetech.com)Licensed under Creative Commons: By Attribution 3.0http://creativecommons.org/licenses/by/3.0
On this episode of Solely Singleton Brad and Eric update The Board Game Cube! The guys start with the update for M19 and C18. Then they poorly segue into a talk about GP Detroit. Finishing the episode with a high level discussion on archetype size. 0:00 Intro 1:39 The Board Game Cube: Update 29:32 GP Detroit 33:54 Archetype size 46:57 Outro The Misers Cube: http://www.cubetutor.com/themiserscube The Board Game Cube: http://www.cubetutor.com/theboardgamecube Brad’s Unpowered Cube: http://www.cubetutor.com/drruler Eric’s Travel Cube: http://www.cubetutor.com/travelcube Contact Information: You can interact with Solely Singleton by joining the hosts on reddit, discord, and twitter to give input to improve the show. Feel free to email questions and comments to the show’s email address. Your Hosts: Brad (DrRuler) & Eric (OnekuoSora) Brad’s Twitter: https://twitter.com/DrRuler Eric’s Twitter: https://twitter.com/OnekuoSora Show Email: SolelySingleton@gmail.com MTG Cube Subreddit: https://www.reddit.com/r/mtgcube/ MTG Cube Discord: https://discordapp.com/invite/tFBZ2Z3 Licensed Music Used: "There It Is" by Kevin MacLeod From the Free Music Archive CC BY "How Exciting" by Revolution Void From the Free Music Archive CC BY "Thursday & Snow (Reprise)" by Blank & Kytt From the Free Music Archive CC BY "Ugly" by Vienna Ditto From the Free Music Archive CC BY "RSPN" by Blank Kytt From the Free Music Archive CC BY “Groovy Baby” by Jason Shaw From the Free Music Archive CC BY
Hello and welcome to another episode of Commander Cookout Podcast! This week on CCOPodcast, the boys discuss Prossh, Skyraider of Kher how he should have been out of the box back in C13. Peep the list here: http://tappedout.net/mtg-decks/cco-goes-prossh-on-your-buttocks-1/?cb=1534899087 If you'd like to tell us how we did, you can shoot an email to commandercookout@gmail.com or get after us on Twitter @CCOPodcast or @CCOBrando. Search us up on Facebook where you can get all the details on the latest giveaway. A C18 deck of your choice! We'll save you the trouble, here's the link: https://www.facebook.com/CCOPodcast/ You can also get all the details for the latest giveaway and all of our backlog on CommanderCookout.com. Head there now! If you'd like to support the show beyond just listening, you can do so here: https://www.Patreon.com/CCOPodcast/ Do not forget, all patrons get additional entries into each giveaway and as of today's episode, patrons will now receive free shipping on all altered art auctions on our Facebook page! Now, Hit our Theme Song!
We're back for another weekly installment of Brawl content just for you! Today, inspired by the idea of using C18 decks as starting points for new commander decks, we talk about upgrading a PW Deck from M19 into a fully-functioning Brawl deck! We're talking about the mono-green deck, which is helmed by Vivien of the Arkbow, and you can see our decklist here (or: http://tappedout.net/mtg-decks/brawlin-with-pw-vivs/?cb=1534290251). Then, we visit the Ravnica Corner for one last time this fall season to talk about everyone's favorite guild, the Izzet. They're wacky, they spellsling, they draw cards, what could be better? Credits to awkwardbun on Twitch for the fantastic artwork, Ant Neely for his song "Might As Well Whistle", which we obtained from the Free Music Archive (http://freemusicarchive.org/music/Ant_Neely/), and of course Wizards of the Coast and Magic the Gathering for giving us something to talk about! You can also contact us on Twitter: @alloutbrawlmtg See acast.com/privacy for privacy and opt-out information.
This week we look at all the new cards from C18 as well as the notable reprints. We go through each deck and let you know our thoughts on the new and returning mechanics, how these decks play out of the box, and what seems worth it to buy in precon form or as singles. It's a long one so buckle in!Go to www.patreon.com/commandersbrew if you'd like to donate to the podcast and get all the cool perks!Head on over to www.wizardtower.com for all your Magic needs! Great prices on singles and free shipping on cards within Canada if you spend $15 or more! Plus if you use our coupon code, summerofbrews, you'll get 5% off any order over $15!Visit www.commandersbrew.com for direct downloads and a streaming version of the podcast.Check out the decks we've brewed on tappedout.net:http://tappedout.net/users/commandersbrewFollow us on twitter at @commandersbrew and individually we are @seantabares and @andyhullbone."There It Is"Kevin MacLeod (incompetech.com)Licensed under Creative Commons: By Attribution 3.0http://creativecommons.org/licenses/by/3.0
Hello and welcome to another episode of Commander Cookout Podcast! This week on CCOPodcast, the boys take a step back and reflect on the new Commander 2018 product and analyze Brando’s deck building procedure/strategy. No lists to peep this week unless you google the Commander 2018 decklists. The Arc of Who Wore it Better was announced and with a new Arc comes a new giveaway! For all the deets on how to get entered to win a C18 deck of your choice, head over to www.CommanderCookout.com or our Facebook, here: https://www.facebook.com/CCOPodcast/ If you’d like to support the show beyond just listening, make sure to head over and become a patron of the show here: https://www.patreon.com/CCOPodcast Of course, Patrons always get their additional entries into our giveaways! After all of that, make sure to find us and like/subscribe/comment on iTunes, Google Play, YouTube.com, Podomatic.com, EDHREC.com, FlipsideGaming.com and wherever else you can pick up our RSS feed. Now, Hit our Theme Song!
We're continuing our coverage of the Commander 2018 product with a look at the BEST NEW CARDS from the set. Before we examined each deck and how to quickly tune it up and get it onto the battlefield as quickly as possible. Today we're taking an overall look at the C18 cards in the context of the greater world of Commander. What's the best new legendary? The best new card for inside the 99 of your current decks? Listen and find out! Learn more about your ad choices. Visit megaphone.fm/adchoices
This week Ian & John finish talking C18 previews and jump in with some hype for PT25! Commander 2018 Card Image Gallery PT 25 Preview As always, you can reach Ian on Twitter @dixonij and on Twitch at twitch.tv/dix. You can find John on Twitter @jwiley129 and on Twitch at the same handle. You can reach the podcast directly over at @eyesonthemise and by email at eyesonthemise@gmail.com. Music by: Can't Stop Won't Stop - Scrape The Sky (feat. Fresh Big Mouf) Download the song: http://lstnto.me/ijp5t6mw6 Check out Can't Stop Won't Stop: http://lstnto.me/ag6ryvspm License music for your own videos: https://usemysongs.com/cswsmusic
This week Sean and Andy start with our C18 brews! Sean takes a look at an Esper Sphinx who loves knowing what's on the top of your library. Will the actual precon deck help out or do we just scrap the whole thing and put good cards in? We'll find out! Check out the decklist here: http://tappedout.net/mtg-decks/yennett-stacking-the-odds/?cb=1532968775Go to www.patreon.com/commandersbrew if you'd like to donate to the podcast and get all the cool perks!Head on over to www.wizardtower.com for all your Magic needs! Great prices on singles and free shipping on cards within Canada if you spend $15 or more! Plus if you use our coupon code, summerofbrews, you'll get 5% off any order over $15!Visit www.commandersbrew.com for direct downloads and a streaming version of the podcast.Check out the decks we've brewed on tappedout.net:http://tappedout.net/users/commandersbrewFollow us on twitter at @commandersbrew and individually we are @seantabares and @andyhullbone."There It Is"Kevin MacLeod (incompetech.com)Licensed under Creative Commons: By Attribution 3.0http://creativecommons.org/licenses/by/3.0
This week Ian is back and moved in, so he and John discuss Ian’s time at SCG Philly and a little bit about C18 previews! Commander 2018 Card Image Gallery As always, you can reach Ian on Twitter @dixonij and on Twitch at twitch.tv/dix. You can find John on Twitter @jwiley129 and on Twitch at the same handle. You can reach the podcast directly over at @eyesonthemise and by email at eyesonthemise@gmail.com. Music by: Can't Stop Won't Stop - Scrape The Sky (feat. Fresh Big Mouf) Download the song: http://lstnto.me/ijp5t6mw6 Check out Can't Stop Won't Stop: http://lstnto.me/ag6ryvspm License music for your own videos: https://usemysongs.com/cswsmusic
It's that time of year, Commander Xmas! Which means we're unwrapping our exclusive COMMANDER 2018 PREVIEW CARD! Meet the newest JUND legendary creature: Gyrus, Waker of Corpses. Come find out what this big bad hydra can do. Note: This is a short episode just for our C18 preview card but don't worry! We have a ton of awesome BONUS CONTENT coming out very soon. This is the best time of year for Commander players and we're going to be taking an in-depth look at all the new stuff from every angle. We only have to wait until more of the set is revealed. Learn more about your ad choices. Visit megaphone.fm/adchoices
Last week, Wizards told us about the themes and color identities of the Commander 2018 precons. In this episode, Nick and Zak share their predictions for Commander 2018, critique the choice of color identities, and analyze what C18's themes need to be viable in CommanderSupport the show (https://www.patreon.com/commandertheory)
Medizinische Fakultät - Digitale Hochschulschriften der LMU - Teil 18/19
As life expectancy has risen steadily over the last years and diseasefree aging is more and more challenging, understanding the complexity of age and aging is of great importance. Metabolomics is one of the novel approaches in systems biology with high potential to deliver answers to these questions. However, only a few metabolic studies based on large samples are available so far. In this thesis, I present results from two population-based studies, the German KORA Follow-Up 4 (KORA F4) study as a discovery cohort with a sample of 1,038 female and 1,124 male healthy participants (32–81 years) and 724 healthy females from UK Adult Twin Registry (TwinsUK) as replication. Targeted metabolomics of fasting serum samples with flow injection analysis coupled with tandem mass spectrometry (FIA-MS/MS) positively quantified 131 metabolites after stringent quality control. Among these, 71 and 34 metabolites were significantly associated with age in females and males, respectively, after adjustment for body mass index (BMI), which is highly correlated (r=0.9) with age. These results indicate that metabolic profiles are age dependent and sex specific. Then, a set of the 12 most age-discriminative, independent metabolites was identified in women with an approach based on random forest and stepwise variable selection. This set showed highly significant differences between subjects aged 32–51 years and 52–77 (p-values range 1.3E-09 – 1.9E-46, significance threshold p=0.004). Ten out of these 12 metabolites replicated in unrelated females from the TwinsUK study, including five metabolites the concentrations of which increased with age (C12:1, C18:1, sphingomyelin (SM) C16:1, SM C18:1 and phosphatidylcholine (PC) aa C28:1), while histidine decreased gradually. Three glycerophospholipids (PC ae C42:4, PC ae C42:5, PC ae C44:4) showed declines around the age of 51 years. Meta-analysis of both studies gave virtually the same results as KORA alone. These observations might reflect many different processes of aging such as incomplete mitochondrial fatty acid oxidation, counteracting oxidative stress, and changes in vascular functions. The identification of these ten age-related metabolites should help better understand aging pathways and networks and with —more discoveries in the future— eventually help enhance healthy aging and longevity.
Episode 4: Nutrition – Does heat-processing adversely affect nutrition? Continuing to examine the big concepts in pet nutrition Effects of heat-processing in commercial foods- Manufacturing affects nutrient quality and bioavailability Extruded 320ºF Canned 500ºF Heating effects: Alterations in protein structure Maillard reactions Bonding of sugar (glucose, fructose, lactose, maltose) with free amino group (such as lysine) Digestive enzymes do not cleave the peptide bond adjacent to the amino acid with attached sugar molecule May increase microbial degradation of taurine in colon Affected proteins are of no nutritional value Allergenic? Other “unusual crosslinking” of amino acids and peptides which result in compounds “not found in nature” “These compounds are not well-used by animals” “Processing EFA in pet foods may affect their biological activity” {Small Animal Clinical Nutrition 4th Ed pp.55, 61} Heating effects: Alteration of fatty acids Trans configuration Metabolized for energy and incorporated into lipid storage Cannot function as EFA's because they are not further metabolized to eicasanoids C18:1 trans isomers inhibit hepatic carnitine and lead to increased liver triacyglycerol by lowering hepatic oxidation of fatty acids {Giudetti AM, Beynen AC, et. al. Hepatic fatty acid metabolism in rats fed diets with different contents of C18:0, C18:1 cis, and C18:1 trans isomers. Br J Nutr. 2003 Nov;90(5):887-93} More pieces to the puzzle of heat processing effects: Carprofen half-life in cats Recent study showed variation 17 hours to 44 hours Difference in liver enzyme activities attributed to diet Fresh, whole foods enhanced liver detoxification Commercial diets detrimental effect Propranolol half-life in cats Study done ~20 years ago showed variation from 1-2 hours to >12 hours Diet effects as seen with carprofen Major pet food manufacturer had no interest in investigating why the variation in metabolism {Dr. William Muir, lecture delivered at Veterinary Chiropractic Convention April 2003, and personal conversation.} Study of food allergy in dogs After successful elimination diet, introduced commercial canned or kibble ‘equivalent' diet 25% recurrence of clinical signs (pruritus) “With every treatment diet tried, some percentage of dogs redeveloped pruritus.” Explanations/Speculations 3-D protein structure altered with heating? Decreased digestibility? Loss of important co-factors? {Rosser, EJ. Diagnosis of food allergy in dogs. JAVMA, Vol. 203, No. 2, July 15,1993 pp.259-262 Pottenger's Cats Nutritional study completed 1932-1942 Multigenerational study Nine hundred cats Four basic feeding groups Optimum diet groups 2/3 raw meat, 1/3 raw milk, Cod Liver Oil 2/3 raw milk, 1/3 raw meat, Cod Liver Oil Deficient diet groups 2/3 cooked meat 2/3 cooked milk (pasteurized, sweetened condensed, evaporated, metabolized vitamin D) Effects observed with deficient diet Dental disease Reproductive abnormalities Allergies Immune disorders Skeletal disease and osteoarthritis Cardiac abnormalities Renal disease Respiratory abnormalities Gastrointestinal abnormalities Hepatic abnormalities Behavioral abnormalities Endocrine abnormalities Ocular abnormalities {http://www.amazon.com/Pottengers-Cats-A-Study-Nutrition/dp/0916764060 } {http://ppnf.org/ } Multigenerational effects – demonstrated “epigenetics” prior to understanding of gene structure or tools to examine Studies in epigenetics reveals that food affects more than just calories and deficiencies…it alters the essence of genetic expression…in the individual…and for subsequent generations Understanding nutrition is critical to longevity and health { NOVA | scienceNOW | Epigenetics | PBS }
Patients with phenylketonuria (PKU) have to follow a lifelong phenylalanine restricted diet. This type of diet markedly reduces the intake of saturated and unsaturated fatty acids especially long chain polyunsaturated fatty acids (LC-PUFA). Long-chain saturated fatty acids are substrates of mitochondrial fatty acid oxidation for acetyl-CoA production. LC-PUFA are discussed to affect inflammatory and haemostaseological processes in health and disease. The influence of the long term PKU diet on fatty acid metabolism with a special focus on platelet eicosanoid metabolism has been investigated in the study presented here. 12 children with PKU under good metabolic control and 8 healthy controls were included. Activated fatty acids (acylcarnitines C6-C18) in dried blood and the cholesterol metabolism in serum were analyzed by liquid chromatographic tandem mass spectrometry (LC-MS/MS). Fatty acid composition of plasma glycerophospholipids was determined by gas chromatography. LC-PUFA metabolites were analyzed in supernatants by LC-MS/MS before and after platelet activation and aggregation using a standardized protocol. Patients with PKU had significantly lower free carnitine and lower activated fatty acids in dried blood compared to controls. Phytosterols as marker of cholesterol (re-) absorption were not influenced by the dietary fatty acid restriction. Fatty acid composition in glycerophospholipids was comparable to that of healthy controls. However, patients with PKU showed significantly increased concentrations of y-linolenic acid (C18:3n-6) a precursor of arachidonic acid. In the PKU patients significantly higher platelet counts were observed. After activation with collagen platelet aggregation and thromboxane B(2) and thromboxane B(3) release did not differ from that of healthy controls. Long-term dietary fatty acid restriction influenced the intermediates of mitochondrial beta-oxidation. No functional influence on unsaturated fatty acid metabolism and platelet aggregation in patients with PKU was detected.
Tierärztliche Fakultät - Digitale Hochschulschriften der LMU - Teil 05/07
Ziel der vorliegenden Studie war die quantitative und qualitative Bestimmung der Gesamtfettsäuren in bovinen Serumproben sowie die Darstellung der Konzentrationsverläufe der einzelnen Fettsäuren während des peripartalen Zeitraums. Des Weiteren sollte festgestellt werden, ob zwischen Kühen, die postpartal an einer Gebärmutterentzündung erkranken, und gesunden Tieren Unterschiede in den Konzentrationen einzelner Fettsäuren bzw. Fettsäuregruppen vorliegen. Die in dieser Studie verwendeten Serumproben stammen von 50 Kühen eines Milcherzeugerbetriebes in Brandenburg. Von den ausgewählten Tieren zeigten 25 Tiere während des Untersuchungszeitraums Symptome einer klinischen Gebärmutterentzündung (puerperale Metritis, klinische Metritis, klinische Endometritis oder Pyometra) und wurden demnach als uteruskrank eingestuft. Die anderen 25 Tiere wiesen keine gesundheitlichen Störungen auf und wurden als uterusgesund eingestuft. Von jedem Tier wurden während des Zeitraums 17 Tage vor bis 28 Tage nach der Kalbung sechs bzw. sieben Serumproben gewonnen. Für die quantitative und qualitative Analyse der Gesamtfettsäuren in den Serumproben wurden die Fettsäuren zu Fettsäuremethylestern (FAME) derivatisiert. Die Probenanalyse wurde mit einem Gaschromatographie/Massenspektrometrie-System (GC/MS-System) durchgeführt. Außerdem wurden die Konzentrationen der freien Fettsäuren (NEFA) in den Serumproben mittels Enzym-Test bestimmt. Sowohl vor wie auch nach der Kalbung konnten bei verschiedenen Fettsäuren Konzentrationsunterschiede zwischen uterusgesunden und uteruskranken Tieren festgestellt werden. Die Konzentrationen der gesättigten Fettsäuren Octadecansäure (C18:0) und Tetradecansäure (C14:0) zeigten in beiden Tiergruppen nach der Kalbung einen leichten Anstieg, wobei die Werte der gesunden Kühe ab dem elften Tag p.p. signifikant höher lagen als bei erkrankten Kühen (P
Fakultät für Biologie - Digitale Hochschulschriften der LMU - Teil 04/06
The aim of this doctoral thesis was to investigate the factors relevant in plant interaction of two plant growth promoting rhizobacteria (PGPR). For this, the strain Acidovorax sp. N35 isolated from surface sterilized wheat roots and the two strains F4 and F7 of Rhizobium radiobacter, a bacterium associated with the plant growth promoting fungus Piriformospora indica, were chosen. First of all, the isolate N35 was characterized using phylogenetic and taxonomic methods. The 16S rRNA gene sequence analysis showed that strain N35 has the closest sequence similarities (98.2, 98.5 and 99.0 %) to the environmental Acidovorax species A. delafieldii, A. facilis and A. defluvii. The DNA-DNA hybridization values clearly separated the isolate from these three species. Additionally, phenotypic properties, such as substrate metabolization profiles as determined by a Biolog GN2 assay and cell wall fatty acid profiles concerning the fatty acids C16:0, C16:1ω7cis/trans, C17:0cyclo and C18:0cyclo and C19:0cyclo, facilitated the differentiation of the newly isolated strain N35 from its closest relatives. Thus, the strain N35 was classified as representative of a new species within the genus Acidovorax, and the name Acidovorax radicis sp. nov. is suggested. “Cand. A. radicis” N35 undergoes an irreversible phenotypic variation, resulting in different colony shapes on agar plate. In soil system, both phenotypes showed a plant growth promoting effect both on barley roots and shoots. The wild type N35 (rough colony type) had a better plant growth promoting effect on barley in comparison with phenotype variant N35v (smooth colony type). Wild type and phenotype variant cells of “cand. A. radicis” N35 were labeled with GFP and/or YFP and their separate and co-colonization behavior was investigated in a monoxenic system and a soil system using a CLSM for detection. Both types of N35 could endophytically colonize barley roots after 12 weeks inoculation in the soil system. Competitive root colonization behavior was observed after co-inoculation with differentially labeled wild type N35 and phenotype variant N35v bacteria, where the wild type showed dominant colonization of barley roots compared to the phenotype variant. Moreover, the variant N35v lost its motility due to missing flagella and swarming ability. The differences of both types at genetic level were investigated using whole genome sequence data obtained from 454 pyrosequencing (Roche) using the GS FLX Titanium chemistry. As only difference in the genome sequence, a 16 nucleotides deletion was identified in the mutL gene, which encodes for the mismatch repair protein MutL. In phenotype N35v, the frame shift caused by this deletion leads to the formation of a stop codon in the coding gene, resulting in a truncated MutL protein with a missing functional MutL C-terminal domain. This mutation occurred in exactly the same way in all investigated phenotype variants. These results suggest that MutL might be directly or indirectly responsible for the phenotypic variation in “cand. A. radicis” N35. Quorum sensing signaling molecules produced by “cand. A. radicis” N35 were identified using biosensors as well as Fourier transform ion cyclotron resonance - mass spectrometry (FT-ICR-MS) and ultra performance liquid chromatography (UPLC). Both types of “cand. A. radicis” N35 possess the same AraI/AraR quorum sensing system, which belongs to the LuxI/LuxR type. The two N35 phenotypes produced nearly the same amount of 3-OH-C10-HSL in the exponential growth phase. A co-inoculation experiment of AHL producing wild type N35 and a constructed AHL negative mutant N35 ΔaraI showed that wild type N35 had a dominant colonization behavior compared to the AHL negative mutant on barley roots in a monoxenic system. These data indicate that quorum sensing is involved in regulation of root colonization by “cand. A. radicis” N35. The second examined PGPR, R. radiobacter, which occurs naturally as endofungal bacterium in the plant growth promoting fungus P. indica, was demonstrated to colonize the surface of barley roots with fluorescence in situ hybridization (FISH) in a monoxenic system. The interaction of P. indica harboring R. radiobacter with other rhizobacteria was investigated using plate confrontation assays. Antibiotics and lipopeptides produced and excreted by the plant growth enhancing rhizobacterium Bacillus amyloliquefaciens FZB42 and the biocontrol rhizobacterium Pseudomonas fluorescens SS101 were shown to be responsible for the observed inhibition of P. indica by these bacteria. R. radiobacter F4 and F7 were able to synthesize a variety of oxo- and hydroxyl-C8- to C12-HSL compounds. In addition, both strains also produced coumaroyl-HSL when coumaric acid was supplied in the medium. The lactonase expressing transformants F4 NM13 and F7 NM13, which are the AHL negative phenotypes, abolished the lipase and siderophore activity. Considering this, quorum sensing influences the production of metabolites including lipase and siderophores in R. radiobacter F4 and F7. Further work should be directed to the question whether quorum sensing also plays a role in the interaction of the bacterium with fungus and/or plant.
Expression of aquaportin-1 in renal cell carcinoma, Hemoglobin depletion from erythrocyte cytosol for 2D gel proteomics, Serum peptide profiling using novel magnetic C18 beads offline coupled to MALDI-TOF MS, "goProteomics" website.
Expression of aquaportin-1 in renal cell carcinoma, Hemoglobin depletion from erythrocyte cytosol for 2D gel proteomics, Serum peptide profiling using novel magnetic C18 beads offline coupled to MALDI-TOF MS, "goProteomics" website.
Background/Aim: Previous studies in vitro and in animals in vivo found that alpha-linolenic acid (C18:3 omega 3) may enhance oxidative damage of essential amino acids. We investigated whether the addition of the long-chain polyunsaturated fatty acids (LCPUFA) arachidonate (C20:4 omega-6; AA) and docosahexaenoate (C22:6-omega 3; DHA) in the form of egg phospholipids to infant formula affects plasma amino acid concentrations and indices of protein metabolism in term infants. Methods: In a double-blind, randomized clinical trial, healthy infants were fed from day 5 of life formula with or without preformed LCPUFA (n = 10 and 12, respectively). At the age of 5 days and 1, 2, 3 and 4 months, blood samples were obtained and analyzed for plasma amino acids by high-performance liquid chromatography and for plasma phospholipid fatty acid composition by gas chromatography. Results: At the age of 3 months, plasma threonine concentrations were significantly lower in infants receiving dietary LCPUFA than in controls (124 +/- 16 vs. 216 +/- 28 mu mol/l, p < 0.05). Values of other plasma essential amino acids, total protein, albumin, creatinine and urea nitrogen did not differ between the two feeding groups throughout the study. At the age of 5 days, plasma phospholipid AA and DHA concentrations were inversely correlated with histidine concentrations (AA: r = -0.60, p = 0.01; DHA: r = -0.53, p < 0.05). At the age of 3 months, DHA concentrations were inversely related to plasma histidine, methionine and threonine concentrations (r = -0.66, -0.62, and -0.64, respectively, p < 0.05). Conclusions: The dietary LCPUFA supplementation of infant formula used in this study has no adverse effects on infant plasma amino acid concentrations and indicators of protein metabolism. Nonetheless, the apparent interaction of LCPUFA with some amino acids in formula-fed infants warrants further investigation.
Patients with glucocorticoid-remediable aldosteronism (GRA) possess a chimeric gene resulting from fusion of the genes encoding steroid aldosterone synthase and 11 beta-hydroxylase. In the adrenal zona fasciculata, this may lead to ectopic expression under ACTH control of aldosterone synthase activity and increased formation of cortisol C18 oxidation products. We assessed mineralocorticoid and glucocorticoid pathways in three patients with GRA. Baseline plasma progesterone, 17 alpha-hydroxyprogesterone, corticosterone, and cortisol were normal in all patients, whereas 11-deoxycorticosterone, aldosterone, and 11-deoxycortisol were above normal. The ratios of both corticosterone/11-deoxycorticosterone and cortisol/11-deoxycortisol were abnormally low, and decreased further 60 min after administration of ACTH-(1-24) (250 micrograms) as an i.v. bolus. A low corticosterone/11-deoxycorticosterone ratio is consistent with an increased aldosterone synthase activity forming aldosterone by corticosterone. Similarly, a decreased cortisol/11-deoxycortisol ratio could reflect enhanced cortisol C18 oxidation. Our findings are in agreement with a hyperfunction of the 11 beta-hydroxylase/aldosterone synthase complex in the adrenal zona fasciculata of GRA induced by the new chimeric gene.
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