Podcasts about catecholamines

My guest is Dr. John Kruse, M.D., Ph.D., a psychiatrist specializing in treating people with attention-deficit/hyperactivity disorder (ADHD). We discuss the many stimulant and nonstimulant ADHD medications available, covering both their potential benefits and risks. We also explore behavioral approaches to managing ADHD, the key role of maintaining a consistent sleep-wake schedule, and the impact of exercise, fish oil supplementation, and video games on ADHD. Additionally, we examine the genetic and environmental factors contributing to the rise in adult and child ADHD diagnoses and offer various options to consider if you or someone you know is struggling with focus. Read the full episode show notes at hubermanlab.com. Thank you to our sponsors AG1: https://drinkag1.com/huberman Eight Sleep: https://eightsleep.com/huberman Joovv: https://joovv.com/huberman LMNT: https://drinklmnt.com/huberman Mateina: https://drinkmateina.com/huberman Timestamps 00:00:00 Dr. John Kruse 00:02:11 Attention-Deficit/Hyperactivity Disorder (ADHD) 00:05:37 Genetics & Environment; COVID Pandemic & ADHD Diagnoses 00:11:43 Sponsors: Eight Sleep & Joovv 00:14:26 ADHD, Interest & Careers 00:20:40 Social Media & Distractibility; ADHD & Lifespan Effect 00:27:39 Hyperfocus, Flow States 00:33:45 Tools: 4 Essential Behaviors for ADHD; Regular Meal Schedule 00:41:06 Sponsor: AG1 00:42:21 Tool: Regular Sleep Timing; Stimulants & Sleep 00:48:06 Insomnia; Tools: Bedtime Structure, Exercise, Phones, Breathing 00:52:30 Nighttime Waking Up; Cyclic Sighing 00:56:35 Exercise; Addiction, Risk, Kids & Stimulants; Catecholamines & Focus 01:04:32 Ritalin, Stimulants, Amphetamines; Amphetamine-Induced Psychosis & Risks 01:16:46 Sponsor: LMNT 01:18:03 Adult ADHD & Medications; Stimulants & Cardiovascular Risk? 01:26:06 Adult ADHD Medication Choices, Psychosis, Cannabis 01:33:49 ADHD Symptoms, Nicotine; Caffeine, Energy Drinks, L-Theanine 01:43:28 Fish Oil, Cardiac Effects & ADHD, Tool: Fish Oil Dose, EPA vs DHA 01:49:38 Sponsor: Mateina 01:51:04 Gut Microbiome 01:52:56 ADHD & Cognitive Behavioral Therapy (CBT), Tool: Task List System 01:57:52 Video Games, Neurofeedback, ADHD Benefit?, Tool: Technology Restriction 02:02:26 Guanfacine, Clonidine, Hypertension, Effects & Timeframe 02:10:13 Modafinil, History & Forms, Dependence 02:19:02 Drug Holidays; Short- vs Long-Acting Drugs, Addiction, Vyvanse 02:28:56 Time Perception, ADHD, Circadian Rhythm Disruption, Phototherapy 02:35:39 Zero-Cost Support, YouTube, Spotify & Apple Follow & Reviews, Sponsors, YouTube Feedback, Protocols Book, Social Media, Neural Network Newsletter Disclaimer & Disclosures

Could the right form of a single vitamin be the difference between thriving and barely surviving? In this Part 2 conversation, human biologist and longevity expert Gary Brecka reveals the #1 overlooked factor that's wrecking your health: methylation—your body's ability to convert nutrients into fuel. If this process fails, your hormones, energy, and even mental health take a nosedive. Gary and Dave dive deep into the real cause of anxiety, ADHD, and mood disorders, the hidden genetic reason why diets fail, and why Big Pharma isn't talking about this critical health breakthrough. Are you unknowingly setting yourself up for disease? What's the simple fix that can reverse anxiety, gut problems, and even prevent genetic disease? And why is your doctor ignoring one of the biggest markers of longevity? What You'll Learn: • The MTHFR gene mutation—and why it's quietly affecting millions • Anxiety, ADHD, and depression—why these disorders start in your cells, not your brain • The gut-brain connection—how your microbiome controls your mood • Why your “healthy diet” might be hurting you (and what to eat instead) • How nutrient deficiencies are passed from mother to child—and how to stop it • The truth about homocysteine—the blood marker that could predict your lifespan • Why most people are living at 50% capacity—and how to get your energy back Resources: • 2025 Biohacking Conference: https://biohackingconference.com/2025 • Gary Brecka's Website: https://bit.ly/4hlfyti • Gary Brecka's YouTube: https://bit.ly/3E3Aaba • Gary Brecka's Instagram: https://bit.ly/3PNsgFe • Dave Asprey's New Book - Heavily Meditated: https://daveasprey.com/heavily-meditated/ • Danger Coffee: https://dangercoffee.com • Dave Asprey's Website: https://daveasprey.com • Dave Asprey's Linktree: https://linktr.ee/daveasprey • Upgrade Collective – Join The Human Upgrade Podcast Live: https://www.ourupgradecollective.com • Own an Upgrade Labs: https://ownanupgradelabs.com • Upgrade Labs: https://upgradelabs.com • 40 Years of Zen – Neurofeedback Training for Advanced Cognitive Enhancement: https://40yearsofzen.com • The Mold Movie!: https://moldymovie.com/ SPONSORS: -BON CHARGE | Go to https://boncharge.com/ and use coupon code DAVE to save 15%. -Qualia | Go to https://www.qualialife.com/dave15 to get an additional 15% off subscriptions. Timestamps: • 00:00 Trailer • 00:31 What Is Methylation? • 01:37 MTHFR, Folate & Your Health • 04:17 How Methylation Affects Disease • 06:41 Nutrient Deficiencies & Health Risks • 07:09 Why Blood Work Matters • 11:44 Homocysteine & Heart Health • 21:37 Catecholamines & Anxiety • 34:28 The Link Between Nutrients & Mood • 34:48 How Catecholamine Ratios Affect Mental Health • 35:39 Personal Health Struggles & Lessons • 36:25 The Role of Methylation in Wellness • 37:57 Methylation & Relationship Dynamics • 39:49 Hidden Dangers of Mold Toxicity • 52:55 Hydrogen Water for Health • 01:01:19 Mitochondria's Role in Longevity • 01:02:23 Final Thoughts See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

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Energetic Health Institute Radio with Dr. Meg Montañez Davenport, BCHN – Depression is a condition deeply rooted in the brain's chemistry, involving key neurotransmitters like serotonin, catecholamines, and endorphins. Understanding how these chemicals influence mood and behavior can help us better grasp the biological underpinnings of depression and open the door to more effective treatments....

Energetic Health Institute Radio with Dr. Meg Montañez Davenport, BCHN – Depression is a condition deeply rooted in the brain's chemistry, involving key neurotransmitters like serotonin, catecholamines, and endorphins. Understanding how these chemicals influence mood and behavior can help us better grasp the biological underpinnings of depression and open the door to more effective treatments....

I talk a lot about the fact that the world has changed. Immune systems, stress responses, metabolic health. We should be questioning our approaches to all of it.  One big change, that we are still gathering data on at Advanced Women's Health, is a liver clearance and bile acid challenge that has become much more prevalent. Although I am still not ready to teach on my protocols to the above-mentioned problems, because I don't teach until we have at least an 70-80% success and reliability rate, I do want to chat about how it's showing up and some factors that may be in play for you to watch for in your practice.Research DiscussedLelou E, Corlu A, Nesseler N, Rauch C, Mallédant Y, Seguin P, Aninat C. The Role of Catecholamines in Pathophysiological Liver Processes. Cells. 2022 Mar 17;11(6):1021. doi: 10.3390/cells11061021. PMID: 35326472; PMCID: PMC8947265.Adam J. Rose, Mauricio Berriel Díaz, Anja Reimann, Johanna Klement, Tessa Walcher, Anja Krones-Herzig, Oliver Strobel, Jens Werner, Achim Peters, Anna Kleyman, Jan P. Tuckermann, Alexandros Vegiopoulos, Stephan Herzig. Molecular Control of Systemic Bile Acid Homeostasis by the Liver Glucocorticoid Receptor. Cell Metabolism, 2011; 14 (1): 123 DOI: 10.1016/j.cmet.2011.04.010Join our Programs! The Holistic Practitioner Growth System April 2024 Click HereTransform Your Practice with the Revolutionary Fasting Mimicking Diet Program Click HereCertified Women's Health Practitioner 2024! Click HereEndometriosis Intensive: Click HereUse code: "endosuperhero" to save $50!The Insulin Intensive: Click Here Stay in touch! NCM Learning Platform | https://learning.naturopathicmentorship.com Advanced Women's Health Website | https://www.advancedwomenshealth.ca/Finally Lose It Book | https://sarahwilsonnd.com/finallyloseitInstagram | https://www.instagram.com/drsarah_nd/ ...

In this episode, we have the honor of speaking with Professor John Myburgh, a former South African physician and researcher who has dedicated his life to improving the field of critical care medicine. Professor Myburgh has made significant contributions to the field of fluid resuscitation, catecholamines, and microbiomes. In this episode, we will be discussing his early years in medicine, some reflections on medicine in South Africa and how his experiences have shaped his research interests. We will also delve into the latest research on fluid resuscitation, catecholamines, and microbiomes. So sit back, relax, and enjoy this fascinating conversation with Professor John Myburgh. Further Reading: SAFE TBI: Cooper DJ, Myburgh J, Heritier S, et al. Albumin resuscitation for traumatic brain injury: is intracranial hypertension the cause of increased mortality?. J Neurotrauma. 2013;30(7):512-518. doi:10.1089/neu.2012.2573 SAFE Study: Finfer S, Norton R, Bellomo R, Boyce N, French J, Myburgh J. The SAFE study: saline vs. albumin for fluid resuscitation in the critically ill [retracted in: Mayr W, Prowse C. Vox Sang. 2004 Aug;87(2):142]. Vox Sang. 2004;87 Suppl 2:123-131. doi:10.1111/j.1741-6892.2004.00468.x CHEST Study: Myburgh JA, Finfer S, Bellomo R, et al. Hydroxyethyl starch or saline for fluid resuscitation in intensive care [published correction appears in N Engl J Med. 2016 Mar 31;374(13):1298]. N Engl J Med. 2012;367(20):1901-1911. doi:10.1056/NEJMoa1209759 PLUS study: Finfer, S., Micallef, S., Hammond, N., Navarra, L., Bellomo, R., Billot, L., ... & Myburgh, J. (2022). Balanced multielectrolyte solution versus saline in critically ill adults. New England Journal of Medicine, 386(9), 815-826. CAT study: Myburgh JA, Higgins A, Jovanovska A, Lipman J, Ramakrishnan N, Santamaria J, CAT Study Investigators. A comparison of epinephrine and norepinephrine in critically ill patients. Intensive care medicine. 2008 Dec;34:2226-34. SOAP II Trial: De Backer D, Biston P, Devriendt J, Madl C, Chochrad D, Aldecoa C, Brasseur A, Defrance P, Gottignies P, Vincent JL. Comparison of dopamine and norepinephrine in the treatment of shock. New England Journal of Medicine. 2010 Mar 4;362(9):779-89. Prof. Myburg on Catecholamines at SMACC/CODA: https://youtu.be/90ru25QuGFI

Noradrenaline (norepinephrine) is a neurotransmitter and hormone that plays a role in the body's "fight or flight" response.  Acetylcholine is a neurotransmitter (“brain” +” across” + “to send”) that helps transmit signals in the brain and body. Its name comes from its chemical structure, an acetate group and a choline molecule.  Dopamine is a neurotransmitter that plays a role in motivation, reward, and movement. Its name comes from its chemical structure, a combination of two molecules called dihydroxyphenylalanine and dopamine. Adrenaline (epinephrine) is a hormone and neurotransmitter that helps the body respond to stress. Its name comes from its source, the adrenal glands.  Serotonin is a neurotransmitter that is involved in mood, appetite, and sleep. Its name comes from its chemical structure, a combination of sero- (meaning "serum") and -tonin (meaning "tonic" or "substance that modifies").  Corticotropin-releasing hormone (CRH) is a hormone that stimulates the release of cortisol, a stress hormone. The name comes from its function of stimulating the release of corticotropin, a hormone that stimulates the adrenal glands. Also, it gets its name from its role in stimulating the release of adrenocorticotropic hormone (ACTH) from the pituitary gland, which in turn stimulates the release of cortisol from the adrenal gland. Vasopressin is a hormone that regulates water balance in the body. Its name comes from its ability to constrict blood vessels (vasoconstriction) and increase blood pressure. Vasopressin, also known as antidiuretic hormone (ADH), is so named because it regulates water balance by causing the kidneys to reabsorb water. Thyrotropin-releasing hormone (TRH) is a hormone that stimulates the release of thyroid-stimulating hormone (TSH), which regulates the thyroid gland. Its name comes from its function of stimulating the release of thyrotropin.  Oxytocin is a hormone that is involved in social bonding, childbirth, and lactation. Its name comes from its ability to stimulate uterine contractions (oxytocic) and milk ejection (lactogenic).  Gonadotropin-releasing hormone (GnRH) is a hormone that stimulates the release of luteinizing hormone (LH) and follicle-stimulating hormone (FSH), which regulate the reproductive system. Its name comes from its function of stimulating the release of gonadotropins.  Growth hormone–releasing hormone (GHRH) is a hormone that stimulates the release of growth hormone (GH), which regulates growth and metabolism. Its name comes from its function of stimulating the release of growth hormone.  Catecholamines are a group of hormones and neurotransmitters that includes adrenaline, noradrenaline, and dopamine. Their name comes from their chemical structure, which includes a catechol group and an amine group.  Histamine is a neurotransmitter and hormone that is involved in inflammation, allergies, and gastric acid secretion. ACTH (adrenocorticotropic hormone) is a hormone that stimulates the release of cortisol from the adrenal glands.  Orexin (hypocretin) is a neurotransmitter that is involved in wakefulness and appetite. Its name comes from its discovery in the hypothalamus and its ability to stimulate food intake (orexigenic).  Glutamic acid (glutamate) is a neurotransmitter that is involved in learning, memory, and neural plasticity. Its name comes from its chemical structure, a combination of glutamine and an acid group.  Galanin is a neuropeptide that is involved in pain perception, mood, and appetite. Its name comes from its discovery in the galanin-containing neurons of the hypothalamus.  Neurotensin comes from the words "neuro," meaning related to nerves, and "tensin," which refers to its ability to cause contraction in smooth muscle. Neurotensin is a neuropeptide that is found in the central nervous system and gastrointestinal tract. --- Support this podcast: https://podcasters.spotify.com/pod/show/liam-connerly/support

Dr. Paul Alexander Liberty Hour – This natural biochemical change is the body's signal to wake up. Catecholamines (dopamine, epinephrine, and norepinephrine) are hormones that are made by the adrenal glands. Myocarditis, which is inflammation of the heart, can lead to irregular heart rhythms that can be lethal without immediate treatment...

Welcome all to IS PHARMACOLOGY DIFFICULT Podcast! I am Dr Radhika Vijay. In this episode, I will be having and audio conference all about descriptions of Endogenous Catecholamines like Nor Adrenaline, Dopamine in different doses, Fenoldopam and Dopexamine. I hope to extend my views about Adrenaline in upcoming episode. I will be covering each of these under head points like receptor action, function, basic route of administration, mechanism, uses and side effects. For all the updates and latest episodes of my podcast, please visit www.ispharmacologydifficult.com where you can also sign up for a free monthly newsletter of mine. It actually contains lot of updates about the medical sciences, drug information and my podcast updates also. You can follow me on different social media handles like twitter, insta, facebook and linkedin. They all are with same name "IS PHARMACOLOGY DIFFICULT". If you are listening for the first time, do follow me here, whatever platform you are consuming this episode, stay tuned, do rate and review on ITunes, Apple podcasts, stay safe, stay happy, stay enlightened, Thank you!! You can access various links via- https://linktr.ee/ispharmacologydifficult Please leave Review on Apple podcasts! Connect on Twitter & Instagram! My books on Amazon & Goodreads!

Welcome all to IS PHARMACOLOGY DIFFICULT Podcast! I am Dr Radhika Vijay.In this episode, I will be having and audio conference all about descriptions of Endogenous Catecholamines like Nor Adrenaline, Dopamine in different doses, Fenoldopam and Dopexamine. I hope to extend my views about Adrenaline in upcoming episode.I will be covering each of these under head points like receptor action, function, basic route of administration, mechanism, uses and side effects.For all the updates and latest episodes of my podcast, please visit www.ispharmacologydifficult.com where you can also sign up for a free monthly newsletter of mine. It actually contains lot of updates about the medical sciences, drug information and my podcast updates also. You can follow me on different social media handles like twitter, insta, facebook and linkedin. They all are with same name "IS PHARMACOLOGY DIFFICULT". If you are listening for the first time, do follow me here, whatever platform you are consuming this episode, stay tuned, do rate and review on ITunes, Apple podcasts, stay safe, stay happy, stay enlightened, Thank you!!You can access various links via- https://linktr.ee/ispharmacologydifficultPlease leave Review on Apple podcasts!Connect on Twitter & Instagram!My books on Amazon & Goodreads!

Welcome all to IS PHARMACOLOGY DIFFICULT Podcast! I am Dr Radhika Vijay. In this episode, I will be giving an introductory overview of Adrenergic Receptors, both Alpha and Beta receptors, their classification, subtypes, action of Catecholamines on these receptors and also I will supplement this great information conversation with a chat about Receptor Regulation, topics like Up and Down receptor regulation, Desensitisation and Supersensitivity of Receptors. With the falling curtain words, I will be wishing all Great festivities and Goodies for this Wizardly, witchy, spooky, fun filled jours of the Halloween Season! Hope everyone has great moments of joy, goodies and celebration!! For all the updates and latest episodes of my podcast, please visit www.ispharmacologydifficult.com where you can also sign up for a free monthly newsletter of mine. It actually contains lot of updates about the medical sciences, drug information and my podcast updates also. You can follow me on different social media handles like twitter, insta, facebook and linkedin. They all are with same name "IS PHARMACOLOGY DIFFICULT". If you are listening for the first time, do follow me here, whatever platform you are consuming this episode, stay tuned, do rate and review on ITunes, Apple podcasts, stay safe, stay happy, stay enlightened, Thank you!! You can access various links via- https://linktr.ee/ispharmacologydifficult

Welcome all to IS PHARMACOLOGY DIFFICULT Podcast! I am Dr Radhika Vijay.In this episode, I will be giving an introductory overview of Adrenergic Receptors,  both Alpha and Beta receptors, their classification, subtypes, action of Catecholamines on these receptors and also I will supplement this great information conversation with a chat about Receptor Regulation, topics like Up and Down receptor regulation, Desensitisation and Supersensitivity of Receptors.With the falling curtain words, I will be wishing all Great festivities and Goodies for this Wizardly, witchy, spooky, fun filled jours of the Halloween Season!Hope everyone has great moments of joy, goodies and celebration!!For all the updates and latest episodes of my podcast, please visit www.ispharmacologydifficult.com where you can also sign up for a free monthly newsletter of mine. It actually contains lot of updates about the medical sciences, drug information and my podcast updates also.You can follow me on different social media handles like twitter, insta, facebook and linkedin. They all are with same name "IS PHARMACOLOGY DIFFICULT". If you are listening for the first time, do follow me here, whatever platform you are consuming this episode, stay tuned, do rate and review on ITunes, Apple podcasts, stay safe, stay happy, stay enlightened, Thank you!!You can access various links via- https://linktr.ee/ispharmacologydifficult

Welcome all to IS PHARMACOLOGY DIFFICULT Podcast! I am Dr Radhika Vijay. Today's episode of the day i.e. "le sujet d'aujourd'hui" is a sequel of last episode and the two highlighted processes that I will cover are the Reuptake and the Metabolism of Catecholamines, all in all the termination of action/effect of catecholamines in nutshell! I will be describing reuptake at neuronal (axonal & vesicle) level and also at extraneuronal sites. Next, I will be covering metabolism of catecholamines aotside neuron as well as in the liver by MAO & COMT enzymes respectively and finally formation of Vanillyl mandelic acid (VMA) which is excreted in urine after glucronide conjugation & sulfation. And with apromise to verbally convey more of such types of tete-a-tetes very soon, it's officially a Wrap of today's conference.... For all the updates and latest episodes of my podcast, please visit www.ispharmacologydifficult.com where you can also sign up for a free monthly newsletter of mine. It actually contains lot of updates about the medical sciences, drug information and my podcast updates also. You can follow me on different social media handles like twitter, insta, facebook and linkedin. They all are with same name "IS PHARMACOLOGY DIFFICULT". If you are listening for the first time, do follow me here, whatever platform you are consuming this episode, stay tuned, do rate and review on ITunes, Apple podcasts, stay safe, stay happy, stay enlightened, Thank you!! You can access various links via- https://linktr.ee/ispharmacologydifficult Please leave Review on Apple podcasts! Connect on Twitter & Instagram! My books on Amazon & Goodreads!

Welcome all to IS PHARMACOLOGY DIFFICULT Podcast! I am Dr Radhika Vijay.Today's episode of the day i.e. "le sujet d'aujourd'hui" is a sequel of last episode and the two highlighted processes that I will cover are the Reuptake and the Metabolism of Catecholamines, all in all the termination of action/effect of catecholamines in nutshell!I will be describing  reuptake at neuronal (axonal & vesicle) level and also at extraneuronal sites.Next, I will be covering metabolism of catecholamines aotside neuron as well as in the liver by MAO & COMT enzymes respectively and finally formation of Vanillyl mandelic acid (VMA) which is excreted in urine after glucronide conjugation & sulfation.And with apromise to verbally convey more of such types of tete-a-tetes very soon, it's officially a Wrap of today's conference....For all the updates and latest episodes of my podcast, please visit www.ispharmacologydifficult.com where you can also sign up for a free monthly newsletter of mine. It actually contains lot of updates about the medical sciences, drug information and my podcast updates also.You can follow me on different social media handles like twitter, insta, facebook and linkedin. They all are with same name "IS PHARMACOLOGY DIFFICULT". If you are listening for the first time, do follow me here, whatever platform you are consuming this episode, stay tuned, do rate and review on ITunes, Apple podcasts, stay safe, stay happy, stay enlightened, Thank you!!You can access various links via- https://linktr.ee/ispharmacologydifficultPlease leave Review on Apple podcasts!Connect on Twitter & Instagram!My books on Amazon & Goodreads!

Huberman Lab Podcast Notes Key Takeaways The immune system has three main systems of protection: physical barriers (e.g., skin, eyes), innate immune system (e.g., white blood cells, killer cells), adaptive immune system (e.g., creation of antibodies)Sickness-related behaviors look a lot like depressive symptoms leading to a theory that depression involves activation of inflammatory cytokinesStimulation of the dopamine pathway can accelerate healing and liberate systems in the body which allow inflammatory pathways to go down and anti-inflammatory pathways to go upWim Hof breathing is a zero-cost tool shown to enhance the immune system by releasing adrenaline and reducing the effects of illness symptomsWim Hof breathing steps:(1) 20-30 deep inhales and exhales through nose; (2) exhale of all air to empty lungs; (3) hold breath for up to 60 seconds; (4) repeat 2-4 roundsMaintaining a healthy microbiome (gut, eyes, mucus) supports good health: nasal breathe as often as possible, don't touch eyes after touching other things, ingest fermented foods to enhance gut microbiotaRead the full notes @ podcastnotes.orgThis episode teaches you a lot about the immune system, immune-brain interactions and offers 12 potential tools for enhancing immune system function. I discuss how our immune system works and science-supported tools we can use to enhance our immune system. I discuss the innate and adaptive immune systems and our various microbiomes-- not just in our gut but also in our nose, eyes and mouth and how to keep them healthy. And I review how specific patterns of breathing and foods maintain a healthy mucosal barrier that is crucial for fighting infections. I discuss how certain neurochemicals called catecholamines enhance our immune system function and how to use specific breathing protocols, types and timing of heat and cold exposure, and, if appropriate, supplementation to activate catecholamines. I also discuss the role and use of serotonin for the sake of accessing the specific types of sleep for recovering from illness, and I discuss how to increase glymphatic "washout" of brain debris during sleep. I also review fever, the vagus nerve and the use of atypical yet highly effective compounds for rhinitis (nasal inflammation). Thank you to our sponsors: ROKA - https://www.roka.com -- code: "huberman" Athletic Greens - https://www.athleticgreens.com/huberman InsideTracker - https://www.insidetracker.com/huberman   Our Patreon page: https://www.patreon.com/andrewhuberman    Supplements from Thorne: http://www.thorne.com/u/huberman    Social: Instagram - https://www.instagram.com/hubermanlab  Twitter - https://twitter.com/hubermanlab  Facebook - https://www.facebook.com/hubermanlab Website - https://hubermanlab.com Newsletter - https://hubermanlab.com/neural-network   Links: How and Why The Immune System Makes Us Sleep - https://www.nature.com/articles/nrn2576    Timestamps: 00:00:00 The Mind & Immune System, New Findings: Acupuncture & Fascia 00:03:00 Sponsors: ROKA, Athletic Greens, InsideTracker 00:07:41 Foundational Tools & Practices for a Healthy Immune System 00:11:20 Immune System Basics: Skin/Mucous, Innate & Adaptive Immune System 00:17:08 Killer Cells, Complement Proteins (“Eat Me!” Signals), Cytokines (“Help Me!” Signals) 00:21:06 The Adaptive Immune System: Antibodies 00:28:00 Tool 1: Nasal Microbiome and “Scrubbing” Bacteria & Viruses; Nasal Breathing 00:30:33 Tools 2 & 3: (Not) Touching Your Eyes; Gut Microbiome & Fermented Foods 00:34:20 Some Interleukins Are Anti-Inflammatory 00:34:56 Sickness Behavior 00:39:08 Some People Seek Care When Sick, Others Want to be Alone 00:42:00 Sickness Behavior & Depression: Cytokines 00:43:40 Reduced Appetites When Sick: Protein, Iron, Libido 00:46:45 Vagus-Nerve Stimulation: Fever, Photophobia, Sleepiness 00:53:03 Humoral (Blood-Borne) Factors, & Choroid Change Your Brain State 00:55:04 Tools 4, 5: Reducing Sickness: Glymphatic Clearance, Pre-Sleep Serotonin, 5HTP 01:07:03 Tool 6: Hot Showers, Saunas, Baths & Cortisol, Heath-Cold Contrast 01:10:53 Feed a Fever & Starve a Cold (?), Adrenaline 01:12:36 Tool 7: Activating Your Immune System w/Cyclic-Hyperventilation, Alkalinity 01:29:10 Brain Chemicals & Cyclic-Hyperventilation; Catecholamines, Dopamine 01:32:10 Mindsets & Immune Function; Yes, You Can Worry Yourself Sick 01:37:00 Tool 8: Healthy Mindsets, Hope, Dopamine; Tool 9: Tyrosine; Tool 10: Cold Exposure 01:42:05 Once You're Already Sick: Accelerating Recovery; Tool 11: Spirulina, Rhinitis 01:46:09 Histamines, Mast Cells 01:49:22 Tool 12: Acupuncture: Mechanism for How It Reduces Inflammation; Fascia, Rolfing  01:53:40 Mechanistic Science & Ancient Practices 01:58:00 Synthesis, Ways to Support Us (Zero-Cost), Sponsors, Supplements, Social Media   Please note that The Huberman Lab Podcast is distinct from Dr. Huberman's teaching and research roles at Stanford University School of Medicine. The information provided in this show is not medical advice, nor should it be taken or applied as a replacement for medical advice. The Huberman Lab Podcast, its employees, guests and affiliates assume no liability for the application of the information discussed.   Title Card Photo Credit: Mike Blabac - https://www.blabacphoto.com

This episode teaches you a lot about the immune system, immune-brain interactions and offers 12 potential tools for enhancing immune system function. I discuss how our immune system works and science-supported tools we can use to enhance our immune system. I discuss the innate and adaptive immune systems and our various microbiomes-- not just in our gut but also in our nose, eyes and mouth and how to keep them healthy. And I review how specific patterns of breathing and foods maintain a healthy mucosal barrier that is crucial for fighting infections. I discuss how certain neurochemicals called catecholamines enhance our immune system function and how to use specific breathing protocols, types and timing of heat and cold exposure, and, if appropriate, supplementation to activate catecholamines. I also discuss the role and use of serotonin for the sake of accessing the specific types of sleep for recovering from illness, and I discuss how to increase glymphatic "washout" of brain debris during sleep. I also review fever, the vagus nerve and the use of atypical yet highly effective compounds for rhinitis (nasal inflammation). Thank you to our sponsors: ROKA - https://www.roka.com -- code: "huberman" Athletic Greens - https://www.athleticgreens.com/huberman InsideTracker - https://www.insidetracker.com/huberman   Our Patreon page: https://www.patreon.com/andrewhuberman    Supplements from Thorne: http://www.thorne.com/u/huberman    Social: Instagram - https://www.instagram.com/hubermanlab  Twitter - https://twitter.com/hubermanlab  Facebook - https://www.facebook.com/hubermanlab Website - https://hubermanlab.com Newsletter - https://hubermanlab.com/neural-network   Links: How and Why The Immune System Makes Us Sleep - https://www.nature.com/articles/nrn2576    Timestamps: 00:00:00 The Mind & Immune System, New Findings: Acupuncture & Fascia 00:03:00 Sponsors: ROKA, Athletic Greens, InsideTracker 00:07:41 Foundational Tools & Practices for a Healthy Immune System 00:11:20 Immune System Basics: Skin/Mucous, Innate & Adaptive Immune System 00:17:08 Killer Cells, Complement Proteins (“Eat Me!” Signals), Cytokines (“Help Me!” Signals) 00:21:06 The Adaptive Immune System: Antibodies 00:28:00 Tool 1: Nasal Microbiome and “Scrubbing” Bacteria & Viruses; Nasal Breathing 00:30:33 Tools 2 & 3: (Not) Touching Your Eyes; Gut Microbiome & Fermented Foods 00:34:20 Some Interleukins Are Anti-Inflammatory 00:34:56 Sickness Behavior 00:39:08 Some People Seek Care When Sick, Others Want to be Alone 00:42:00 Sickness Behavior & Depression: Cytokines 00:43:40 Reduced Appetites When Sick: Protein, Iron, Libido 00:46:45 Vagus-Nerve Stimulation: Fever, Photophobia, Sleepiness 00:53:03 Humoral (Blood-Borne) Factors, & Choroid Change Your Brain State 00:55:04 Tools 4, 5: Reducing Sickness: Glymphatic Clearance, Pre-Sleep Serotonin, 5HTP 01:07:03 Tool 6: Hot Showers, Saunas, Baths & Cortisol, Heath-Cold Contrast 01:10:53 Feed a Fever & Starve a Cold (?), Adrenaline 01:12:36 Tool 7: Activating Your Immune System w/Cyclic-Hyperventilation, Alkalinity 01:29:10 Brain Chemicals & Cyclic-Hyperventilation; Catecholamines, Dopamine 01:32:10 Mindsets & Immune Function; Yes, You Can Worry Yourself Sick 01:37:00 Tool 8: Healthy Mindsets, Hope, Dopamine; Tool 9: Tyrosine; Tool 10: Cold Exposure 01:42:05 Once You're Already Sick: Accelerating Recovery; Tool 11: Spirulina, Rhinitis 01:46:09 Histamines, Mast Cells 01:49:22 Tool 12: Acupuncture: Mechanism for How It Reduces Inflammation; Fascia, Rolfing  01:53:40 Mechanistic Science & Ancient Practices 01:58:00 Synthesis, Ways to Support Us (Zero-Cost), Sponsors, Supplements, Social Media   Please note that The Huberman Lab Podcast is distinct from Dr. Huberman's teaching and research roles at Stanford University School of Medicine. The information provided in this show is not medical advice, nor should it be taken or applied as a replacement for medical advice. The Huberman Lab Podcast, its employees, guests and affiliates assume no liability for the application of the information discussed.   Title Card Photo Credit: Mike Blabac - https://www.blabacphoto.com

Weight training is the most important type of exercise for fat loss, overall health, and mental and physical strength and resilience.  No, that's not a typo. Weight training is more important than cardio, even for getting and staying lean. Unfortunately, through public health propaganda, we've been led to believe that low-fat, minimal meat diets and lots of cardio are the solution. They're not.  A new study adds to the fat-burning benefits of resistance training. How Resistance Training Stimulates Fat Loss Strength training helps you shed fat through multiple mechanisms, some direct and some indirect. Catecholamines and Lipolysis This one is a bit technical, but I wanted to include it for those who get geeked out by physiology like I do. In August of 2021, Vechetti IJ, et al. published Mechanical overload-induced muscle-derived extracellular vesicles promote adipose tissue lipolysis. Their research showed, for the first time, how resistance-trained muscles directly increase fat metabolism. The catecholamines norepinephrine and epinephrine stimulate -adrenergic receptors in fat cells, which enhances insulin sensitivity, muscle mass, and metabolic rate. Ephedrine was one of the most powerful supplements for triggering this process, which is why it was so effective for fat loss. However, the FDA banned its use in supplements in 2004 based on concerns of cardiovascular risk. First using animal and human in vitro studies, and then animal and human in vivo studies, NAME, et al. found that overloaded muscle tissue, like that exposed to a hypertrophy-style strength training session, has a similar effect. When skeletal muscles are overloaded, they release microRNA 1 (miR-1) containing extracellular vesicles (EVs). Epidydimal white adipose tissue (eWAT) then takes up those EVs, which increases B-adrenergic (AdrB3) expression, which increases lipolysis (fat breakdown). Since the increased levels of catecholamines also increase overall energy expenditure, the fatty acids can then be used for energy, reducing fat mass. Increased glycogen storage and reduced blood sugar When you eat carbohydrates, you use them one of four ways: Burn them for your immediate energy needsStore them in your liver and muscle cells as glycogenLet the glucose float around in your blood, which causes significant damage as is seen in those with type II diabetesConvert them to triglycerides and fat It would be impossible for most of us to eat a meal's worth of carbohydrates, and then burn them immediately afterwards. That means the last three scenarios are the most likely. This is where resistance training comes in. The more muscle you have, the more capacity you have for storing carbohydrates. That means when you eat them, you have a place to put them so they won't leave you with elevated blood sugar and you won't convert them to fat and get fatter. Unfortunately, most diabetes doctors significantly under emphasize the importance of resistance training. They leave a patient feeling like strength training is an optional activity, rather than hitting them over the head with its importance. Type II diabetes need not be a lifelong condition. At its core, it's an issue of carbohydrate intolerance. By reducing dietary carbohydrates and increasing carbohydrate storage capacity through resistance training, most people can regain their health and don't need to survive by using pharmaceuticals. Supplements like berberine and other lifestyle hacks can help, too. But if you're serious about controlling your blood sugar, you'll make strength training a nonnegotiable part of your lifestyle. By controlling blood sugar, you maintain lower insulin levels, which allows you to tap into your fat stores for more of your energy needs. Improved strength and stamina which increases physical activity  Weak bodies tend to be more sedentary. Sedentary bodies lead to weak bodies.

Neurotransmitters act as chemical signals from our nerve endings to various target cells found in muscles, glands, and other neurons. Although there are many types of neurotransmitters, today we will focus on the catecholamines - epinephrine, norepinephrine, and dopamine. Anyone who has ongoing stress or is an ‘adrenaline junkie’ can attest to the physical effects of the catecholamines. But did you know that they also play a role in our brain’s reward system to make us happy and feel good? Listen in as we discuss the importance of catecholamines, their downstream metabolites, and why we measure them. Today on The Lab Report: 2:10 What is a neurotransmitter? 3:25 Introduction to catecholamines 6:00 Dopamine and the reward system 8:20 Epinephrine, norepinephrine, and the stress response 11:30 Neurotransmitter breakdown and downstream metabolites 16:50 Question of the Day How does caffeine affect catecholamines?   Additional Resources: NutrEval Metabolomix + Organic Acids Subscribe, Rate, & Review The Lab Report Thanks for tuning in to this week’s episode of The Lab Report, presented by Genova Diagnostics, with your hosts Michael Chapman and Patti Devers. If you enjoyed this episode, please hit the subscribe button and give us a rating or leave a review. Don’t forget to visit our website, like us on Facebook, follow us on Twitter, Instagram, and LinkedIn. Email Patti and Michael with your most interesting and pressing questions on functional medicine: podcast@gdx.net. And, be sure to share your favorite Lab Report episodes with your friends and colleagues on social media to help others learn more about Genova and all things related to functional medicine and specialty lab testing. Disclaimer: The content and information shared in The Lab Report is for educational purposes only and should not be taken as medical advice. The views and opinions expressed in The Lab Report represent the opinions and views of Michael Chapman and Patti Devers and their guests. See omnystudio.com/listener for privacy information.

Show Summary: “Neurotransmitters are basically neuro chemicals in your body that control every aspect of it - your digestion, muscles, mood, and are very related to anxiety, depression, sleep, and peristalsis of your gut. They are involved in every single function of the body.”Dopamine and Serotonin are neurotransmitters and are very powerful. Being deficient in it can make you feel exhausted, unmotivated and can cause anxiety and depression. Medical professionals see it as something critical because it can contribute to hormone dysregulation. Another thing that can trigger depression and anxiety is mold as it is often invisible and misdiagnosed.What's even trickier about this is people often think that they don't have mold in their homes. Surprisingly, it can cause an illness in any organ or our thyroid glands and create symptoms like brain fog. That's why Dr. Ann-Marie Barter believes that every household needs to address this and that more people need to be tested for mold toxicity. In this episode, Dr. Ann-Marie Barter, a Chiropractor and Functional Medicine practitioner in private practice in Denver, Colorado tells us more about hormonal issues, its causes and effects and how we can address it initially. Listen as she breaks down every aspect you need to know about what could be causing your stress, anxiety, depression or some other illnesses. Important LinksGutsy Health WebsiteFearless Health PodcastWebsite for practiceProducts:Dopamine & Serotonin support (Sugar Cravings Support)Serotonin and Gaba support - Relax and calm down (Mood Relief)Magnesium supplements InstagramFacebookExceptional Highlights:Most people are actually deficient with neurotransmitters across the board.Sugar is a legal drug we are all dependent and addicted to, and the food industry is well aware of thisBe careful with mold exposure - Mold is a great imitator. It mimics many diseases and dysfunctions in the bodyShow Highlights: How do you usually address Neurotransmitters when people come to you with health issues?Ann 6:43I think two things are really important to address before you deal with neurotransmitters. The gut - it’s very important. If you have all this gut dysregulation, then guess what? You have to fix that first.What are Catecholamines?Ann 9:09When we're looking at dopamine, basically you’re fight or flight, (which are catecholamines), this helps us run from a bear. But you need to be able to transition between being motivated, focused and feeling worthwhile and hopeful to be unable to run from that bear. Because that pathway for dopamine, is the same as your catecholamines pathways that fight or flight. And you have to be able to transition between the two seamlessly. Support the show (https://www.mygutsyhealth.com/gutsy-family)

Join Yvonne Brandenburg, RVT, VTS SAIM and Jordan Porter RVT, LVT, VTS SAIM as we talk about: When endocrine and neurology combine! There is a catecholamine explosion. Epinephrine, norepinephrine, and dopamine; OH MY! Oh yes, you guessed what we are talking about, the small tumor that is a pheochromocytoma.   Question of the Week Have you ever seen a pheochromocytoma?  Leave a comment at https://imfpp.org/episode59   Resources We Mentioned in the Show  Purdue Newsletter: Canine Pheochromocytoma  https://www.addl.purdue.edu/newsletters/2007/Spring/CP.htm Merck Veterinary Manual: Endocrine System, Neuroendocrine Tumors: https://www.merckvetmanual.com/endocrine-system/neuroendocrine-tumors/pheochromocytomas Marshfield Labs:  https://www.marshfieldlabs.org/sites/ltrm/Human/Pages/22190.aspx#PerformingTab  Linda Merrill, (2012). Small Animal Internal Medicine for Veterinary Technicians and Nurses. Ames: Wiley-Blackwell. Colville, T., Bassert, J. (2016). Clinical Anatomy and Physiology for Veterinary Technicians. St. Louis: Mosby, Inc.   Thanks so much for tuning in. Join us again next week for another episode!  Want to earn some RACE approved CE credits for listening to the podcast? You can earn between 0.5-1.0  hour of RACE approved CE credit for each podcast episode you listen to.    Join the Internal Medicine For Vet Techs Membership to earn and keep track of your continuing education hours as you get your learn on!   Join now! http://internalmedicineforvettechsmembership.com/   Get Access to the Membership Site for your RACE approved CE certificates Sign up at https://internalmedicineforvettechsmembership.com  Get Access to the Technician Treasure Trove  Sign up at https://imfpp.org/treasuretrove    Thanks for listening!  – Yvonne and Jordan 

Physiological facts:  Haemodynamics are complex and represent a teleological neurohormonal response to stress.   Defence of MAP represents the balance between the afferent and efferent circulations and the compliance of the system.  Monitoring is an aid to an overall assessment that must be considered within the clinical context and patient’s trajectory of illness.  Pharmacological facts:  Catecholamines are hormones that are administered to augment inadequate endogenous responses. Synthetic catecholamines have no established role in clinical practice. Neurohormonal supplementation strategies have limited roles and should be confined to indications established from RCTs. Non-catecholamine inodilators have not been demonstrated to improve patient-centred outcomes in critically ill patients.

Link to bioRxiv paper: http://biorxiv.org/cgi/content/short/2020.06.25.171199v1?rss=1 Authors: Pfeffer, T., Ponce-Alvarez, A., Meindertsma, T., Gahnstrom, C., van den Brink, R. L., Nolte, G., Tsetsos, K., Engel, A. K., Deco, G., Donner, T. H. Abstract: The catecholamine and acetylcholine systems control global brain states. Influential theoretical accounts postulate distinct computational roles of these systems. But previous empirical work observed only subtle, quantitative differences between their effects on single-neuron responses in the cortex. Here, we report a double dissociation between catecholamine and acetylcholine effects on large-scale cortical dynamics in humans. A pharmacological boost of catecholamine levels increased the cortex-wide coupling between regional fluctuations of population activity during a visual task. In contrast, a pharmacological acetylcholine boost decreased coupling during rest. Circuit modeling explained these results by distinct changes in local cortical circuit properties (specifically, excitation/inhibition balance) and predicted that catecholamines would promote more exploratory choice behavior. Indeed, we observed increased exploration under catecholamine boost in two behavioral tasks. We conclude that distinct local circuit mechanisms cause dissociated context-dependent catecholamine and acetylcholine effects on large-scale cortical dynamics. Copy rights belong to original authors. Visit the link for more info

Max recommended amount of caffeine per day is 400mg. @Chubbyemu case report video ► https://youtu.be/wj_AOzSSDMM Video version of this episode ► https://youtu.be/rn-WLpa_nyQ Instagram me: https://www.instagram.com/hemereview Facebook me: https://www.facebook.com/hemereview Tweet me: https://www.twitter.com/hemereview Music by @Lifeformed Some caffeine is OK. 1-2 cups of coffee can generally be ok. Unreasonably large amounts of caffeine NOT OK. References: [0] Hensher C, Vogel J. Insulin Euglycemic Therapy in the Treatment of Caffeine. Chest. 2020 May;157(5):e145-e149. https://pubmed.ncbi.nlm.nih.gov/32386647/ [1] Multi-modal contributions to detoxification of acute pharmacotoxicity by a triglyceride micro-emulsion. J Control Release. 2015 Jan 28; 198: 62–70. [2] Rall TW, Sutherland EW. Formation of a Cyclic Adenine Ribonucleotide By Tissue Particles. J Biol Chem 1958, 232:1065-1076. [3] A Case of Exercise-Induced Rhabdomyolysis Associated With A Weight Loss Dietary Supplement. Military Medicine, 172, 6:656, 2007. [4] Yamada Y, et. al. The mode of action of caffeine on catecholamine release from perfused adrenal glands of cat. Br. J. Pharmacol. (1989), 98, 351-356. [5] Effects of Caffeine on Plasma Renin Activity, Catecholamines and Blood Pressure. N Engl J Med 1978; 298:181-186. [6] Caffeine resulting in severe rhabdomyolysis and acute renal failure. American Journal of Emergency Med 32 (2014) 111.e3-111.e4. [7] Eteng, MU, et. al. Recent advanced in caffeine and theobromine toxicities: a review. Plant Foods for Human Nutrition 51: 231-243, 1997. [8] Jabbar SB, et. al. Caffeine: A case report and review of literature. Am J Forensic Med Pathol. Vol 34, N4, Dec 2013. [9] Bioh G. et. al. Survival of caffeine. BMJ Case Rep 2013. bcr-2012-007454. --- Support this podcast: https://anchor.fm/chubbyemu/support

Episode 307 continues off my original "Fat Burner Family Tree" concept and now we take a quick dive into the catecholamine portion of things as its how many of your traditional "fat burners" are going to potentially be aiding you in your fat loss efforts!    View the original Fat Burner Family Tree: https://www.theprepcoachforum.com/post/the-fat-burner-family-tree-part-1-100-references-10370258?pid=1310495721   View the Catecholamine Portion: https://www.theprepcoachforum.com/post/show_single_post?pid=1310589872&postcount=9&forum=658127      •••SUPPORT OUR SPONSORS•••   (COACHING) Alex - www.theprepcoach.com   (FREE OPEN FORUM w/ EXCLUSIVE VIDEOS) http://www.theprepcoachforum.com   (SUPPLEMENTS) www.projectad.me___use discount code “BFR25” to save off your order!   (RESEARCH CHEMS) www.maresearchchems.net___use discount code “alex15” to save off your order!   (SPECIALTY SUPPS) www.masupps.com___use discount code “alex20” to save off your order!   (BULK SUPPLEMENTS) www.truenutrition.com___use discount code “AXK5” to save off your order!       •••FIND THE EPISODES•••   ITUNES:https://itunes.apple.com/us/podcast/beastfitness-radios-podcast/id1065532968   LIBSYN:http://beastfitnessradio.libsyn.com   VIMEO: www.vimeo.com/theprepcoach        •••PREP COACH APPAREL•••   https://teespring.com/stores/the-prep-coach-apparel    

Let’s talk about some genetic SNP’s that are associated and supported in recovering autism. Single nucleotide polymorphisms, often referred to as SNPs (pronounced “snips”) are basic genetic variations in people. Respectively, in a DNA sequence. There are thousands of genes associated with AUTISM and all of them have been randomized out in clinical trials which tells us that autism is largely environmental! However, even though our genes do not define us, they can guide our way toward healing.  Genetic susceptibilities come from trauma, both physical, emotional, and from toxic insult. Less than five percent of humans have genetic defects at birth. Some favorite SNP’s that can be associated and supported in recovering autism: MTHFR  It is estimated that 98% of people with autism have the MTHFR gene snip. MTHFR or methylenetetrahydrofolate reductase gene (methyl-ene-tetra-hydro-folate-reductase), when working properly, produces the MTHFR enzyme, MTHFR (5,10-methylenetetrahydrofolate reductase). However, if the gene is mutated it will not be able to make important compounds such as protein, and it disrupts the methylation cycle, otherwise known as detoxification. MTHFR gene mutation also disrupts the body’s ability to make the master antioxidant, glutathione. When the body cannot detoxify properly the toxins build up in the body and cause a myriad of health problems. MTHFR is also responsible for creating the process of converting the amino acid homocysteine to methionine. Methionine is the amino acid our body uses to make proteins. With the MTHFR mutation metabolic issues are common, and so is the deficiency of folate, vitamin Methyl B12 , (vital for proper function of many things including methylation, digestion and food absorption), and pyridoxine (vitamin B6, for brain function and coping with stress), or mutations of related enzymes. Folate is natural and comes from food sources such as green vegetables, beans and other whole plant foods. It is responsible for synthesizing DNA, making red blood cells, transporting oxygen, and supports the functioning of our nervous and cardiovascular systems. Adequate B vitamins, including folate are also necessary for proper cognitive function. Folic acid is synthetic and commonly in multivitamins and fortified foods. This can cause excess to build in the body. The body has a limited ability to convert folic acid to folate. Too much folic acid can affect gene expression, may reduce immune system function, and exacerbate vitamin B12 deficiency. It is critical to make sure to check your multivitamin, because most will contain folic acid and not folate.   With the MTHFR mutation it is important to reduce inflammatory foods from the diet such as gluten, dairy, processed carbohydrates and sugars. detoxification and the use of toxin binders can be very helpful. Common health issues related to a disruption in the MTHFR gene are: Food allergies Inflammation Alzheimer’s Cardiovascular problems ADD/ADHD thyroid issues Chronic fatigue Eczema Infertility Drug sensitivities Tactile sensitivity A couple of physical signs to look for that refer to MTHFR are: A sacral dimple. This would be on the top and center of the gluteal fold. A blue line in between the eyebrows. Tongue tie   COMT   COMT stands for Catechol-O-methyltransferase and is an enzyme that breaks down hormones secreted by the adrenal glands to help us stay calm and handle stress. They are in a category of chemicals called catecholamines which are also neurotransmitters, or brain messengers, such as dopamine (our feel good chemical), epinephrine (also known as adrenaline), and norepinephrine (a stress hormone and a neurotransmitter). COMT deactivates these neurotransmitters in a process that uses S-adenosyl methionine, or SAMe. SAMe assists with many things including motivation. SAMe is part of the methionine cycle which needs the help of the MTHFR enzyme to complete these chemical processes. Therefore, MTHFR and COMT are both needed. A mutation in either one of these genes causes a disruption in the physical and emotional effects of the individual. Supplements that can be helpful: Magnesium is required for proper COMT function. Vitamin B6 is a cofactor to the COMT enzyme, so it can be helpful in its ability to be properly activated, but it must be added in slowly to avoid reactions.. Studies show “Catecholaminergic systems are involved in the regulation of aggressive behavior”. (Catecholamines and aggression: the role of COMT and MAO polymorphisms.) PON 1 The PON 1 gene relates to how our body’s metabolize organophosphates. It also relates to the susceptibility of vaccine reactions.  Histamine Sensitivity (DAO) Histamines are released by the digestive tract and the brain. When the DAO enzymes are mutated then it is difficult to remove histamine.  Histamine reactions come from the body having an allergic reaction. The body sees a food as an allergy when the immune system gets triggered to release histamine. Common symptoms are hives, extreme mood changes, poor sleep, Common causes are related to leaky gut and the MTHFR gene mutation. This can happen when an ill gut blocks methylation (MTHFR).  For SNP’s and autism health to become balanced it is crucial to heal the gut and regulate a proper diet, and avoid specific foods beginning with a food guide. In Summary The SNP’s or snips, MTHFR , COMT, MAO, and histamines can contribute or be the cause of both physical and behavioral issues such as manic or depressive behaviors, pain disorders, aggression, anxiety, poor sleep, food allergies, inflammation, and much more. By working with a supportive diet and natural supplementation we can improve these symptoms and the health and behavioral symptoms of autism. Diet is exceptionally important and the gut must be healed properly. Click Here for more details.

Insulin and ketone metabolism expert, Ben Bikman, PhD is back on the show for part 2--and it's a epic conversation. (If you missed episode #250, it was a great one, I’ll put a link to it on the show notes page.) ➢ This episode is brought to you by ButcherBox.com   Serving the High Intensity Health community with truly 100% grass-fed, pasture raised beef, chicken and pork. Get $20 off your order and free heritage bred bacon, for life! https://www.butcherbox.com/hih-2 About today’s show: Show Notes: https://highintensityhealth.com/250 Ben and I expand on the first discussion--diving further into why glycogen depletion and glucagon are needed and helpful in helping to kick-start fat loss and ketone production. We also discuss nuances around protein, mTOR and building muscle. Here’ s quick run-down of the time stamps: 05:49 We are applying the low carb ketogenic diet in bizarre ways by dumping oil into their drinks. There is no other nutritional value to the oils. Eggs are loaded with nutrition. Dr. Bikman mixes raw egg into his morning tea. 07:45 Fasted exercise stimulates glucagon. Our red blood cells need glucose. When we need gluconeogenesis, glucagon will be elevated. If you are low carb, exercising in a fasted state, or you are fasted, you need gluconeogenesis. Glucagon will be elevated and insulin, which inhibits gluconeogenesis, will be low. 09:37 People may be confusing gluconeogenesis with an insulinogenic effect. If you are low carb, gluconeogenesis happens only as much as you need it. 10:40 If you have ketogenesis happening, you have gluconeogenesis. Fat is used for fuel, and parallel, we have the need for new essential glucose to be produced. 13:14 Depleting glycogen is a necessary event before ketogenesis kicks in. 14:10 True clinical hypoglycemia is remarkably uncommon. If you are insulin resistant, and your brain has been depending upon high glucose and has had no time to adapt to using ketones for fuel, glucose levels can get low. Your body senses this and panics. There is more than enough glucose. 17:03 There are two phases of hunger. The first phase is hunger from empty guts. It is passing. The second phase of hunger is when your body says that there is a genuine deficiency of energy and you want to eat anything and will do anything to get it. 18:22 As long as you have sufficient salt and water consumption, you are good for exercise. If you have food in your gut, your body is conflicted about sending blood to your muscles or your guts. 19:57 Protein increases insulin and glucagon. Other macros increase one or the other. 21:02 Glucagon is catabolic of fat tissue. There are not many glucagon receptors in muscle. 21:55 If you are low carb or fasted and you need gluconeogenesis, there is no appreciable increase in insulin from the protein, yet a substantial increase in glucagon. 23:00 Glucagon activates lipolysis, increasing free fatty acids. The liver sees more fatty acids, but since insulin is low, the liver will not store the fat. Hormones tell the body what to do with energy. 23:54 Acetyl-CoA is the branch point of all metabolic processes in the liver and most other cells. It can be used for creating new glucose, activating gluconeogenesis, create lipids through lipogenesis and it can to into the citrate cycle and be used for energy, creating ATP, or it can be used for ketogenesis. All of this is dependent upon insulin. Catecholamines and glucagon counter insulin, but insulin reigns supreme. 25:40 Consuming meat or saturated fat does not create lipotoxicity, nor insulin resistance. 27:36 In animal and human studies of saturated fat, fat was administered intravenously. Elsewhere it was tested against muscle tissue in the lab, which does not reflect the complex systems of the body, especially the influence of insulin. Both of these formats helped to form our mechanistic thinking of how saturated fat can cause insulin resistance. 30:17 It is easier to induce insulin mediated lipotoxicity with a vegan diet than a ketogenic diet due to the high carb content. 30:43 Excess palmitate can create an excess of ceramides, as can hyperinsulinemia directly. 32:39 Triglycerides do not effect insulin sensitivity. 33:45 There are more ceramides in sedentary, obese, insulinemic individuals. They also have higher levels of circulating fatty acids. This is because the liver is making more fat or the adipocytes are becoming increasingly insulin resistant. Thus adipocytes are spilling lipid into the blood. The lipids switch from inert triglycerides to ceramides. 34:53 Alpha cells become insulin resistant because of a ceramide accumulation. We have a microenvironment in the pancreas. Butted up against each other, you have an alpha cell that releases glucagon and a beta cell that releases insulin. Insulin from the beta cell tells the alpha cell not to make glucagon. Within this environment is a greater amount of insulin than in our system. This means that the alpha cell is getting hundreds, maybe thousands of times more insulin than other tissues. 35:52 In type 1 diabetes, where you are not making insulin in the microenvironment, too much glucagon is produced, elevating glucose. 36:18 An insulin resistant person, who’s insulin levels have been climbing over the decades, but there is enough to keep glucose in check, remains clinically silent. Viewing diabetes as an insulin disease results in better treatment and earlier detection. 36:43 Eventually, glucose levels rise and you are a type 2 diabetic. This could be when the alpha cells become insulin resistant. Insulin tells the alpha cell to make less glucagon, unless the alpha cell becomes insulin resistant and glucagon climbs. This signals the liver to start pumping out glucose. 37:30 Both insulin and glucagon are high in type 2 diabetics. It should be one or the other. 38:13 Weight gain results from insulin therapy for both type 1 and type 2 diabetics, even if caloric consumption remains the same. 40:15 Exogenous ketones shut down your body’s ability for hepatic ketogenesis. Pulsed exogenous ketones can be helpful with TBI or other neurological issues. 41:55 Glucagon activates processes that are involved in mitochondrial biogenesis. 44:18 Ketones are energy. When you do endurance exercise with high blood glucose, glucose drops. When you do endurance exercise in a fat adapted state, your ketones will drop. 44:47 As you become more fat adapted, your body becomes more efficient and ketone baseline levels drop. 44:57 The definition of ketosis had been arbitrarily set at .5 mml. It is being considered to start at .3 mml due to the body’s efficiency shifts in fat adaptation. Once ketones are detectible from a low carb diet (and not exogenous ketones or MCT), metabolic pathways have been activated and insulin is low. You will be catabolic of your fat tissue. 47:53 You cannot store ketones if insulin is low. If insulin is elevated, even a ketone brought in exogenously, is converted to acetyl CoA and can be stored. 47:57 Hormones drive energy utilization. 51:54 Any cell that you want to maintain and grow requires mTOR. Insulin promotes mTOR activation. 52:55 Leucine is a good mTOR activator in muscle. 53:22 A cancer cell will grow with chronic mTOR activation, but it is not the cause of the cancer. 54:41 Protein consumption does not correlate to cancer incidence. There is evidence that a vegetarian diet, resulting in low levels of LDL. Low LDL is associated with 15 times greater risk of leukemia. 55:41 Animal products are higher in protein and we absorb more. Plants are relatively deficient in protein and we do not absorb it effectively. The longer you live a life with low insulin, the better off you will be. Fasting insulin levels impact Alzheimer’s risk more than age does. 59:17 Carnitine is involved in lipid transport. Longer chain fatty acids need a carnitine shuttle. Low levels of carnitine can be a bottle neck for the mitochondria’s ability to oxidize lipids. 01:00:41 Leucine is the most anabolic amino acid and is a ketogenic amino acid. 01:01:22 Red meat is a great source of carnitine. Carnitine accelerates ketogenesis. We can make our own carnitine. Low carb vegetarians may benefit for supplemental carnitine. Chicken is not a good carnitine source. 01:03:55 Cold induced uncoupling can stimulate mitochondrial uncoupling in muscle. If mitochondria are uncoupled, which means we have mitochondria pulling in glucose and fat and burning it to create heat. Where mitochondria are more tightly coupled, breaking down only enough energy as requested by the cell. 01:05:19 Ketones induce mitochondrial uncoupling in fat tissue, telling it that it is okay to waste energy. In muscle cells, it does not increase mitochondrial uncoupling. It is beneficial for your muscle to only use the energy it needs to use. 01:05:24 Body temperature rises from exercise out of an inherent inefficiency in all chemical reactions. 01:08:56 Cold exposure has an immune benefit and a cognitive benefit, as well as the metabolic benefit. 01:15:39 A main cause of endotoxemia can be LPS (lipopolysaccharide), a membrane component of bacteria. LPS is inhaled or absorbed from the gut. This is accelerated when your body is absorbing lipid. 01:16:47 With lipid absorption, there can be an increase of LPS and endotoxemia. However, dietary lipid consumption also increases LDL. LDL can bind to LPS and result in its removal through the bile duct. Fructose increases LPS, but does not increase LDL. Show Notes: https://highintensityhealth.com/250  

Over the past couple of decades, we have seen a big increase in neurotransmitter dysfunction ranging from anxiety and depression, to Alzheimer's and even Schizophrenia. The 4 main neurotransmitters that we pay attention to are: Serotonin GABA Catecholamines Endorphins There has been a lot of information coming out about the power of the Ketogenic Diet for optimal brain function, but that relates mostly to the brain cells using ketones as the primary fuel source compared to glucose. What we don't hear about often enough is the types of amino acids needed to produce neurotransmitters. The post 53- Amino Acid Therapy For Optimal Brain Function with Laurie Hammer appeared first on Summit For Wellness.

Show Notes for Podcast Five of Sex & Why Host: Jeannette Wolfe Topic: Stress Response This Podcast focuses on the basics of the acute human stress response. Please see Dr Morgenstern's excellent write up: Performance Under Pressure Review: https://first10em.com/2017/03/13/performance-under-pressure/ Components of stress response Trigger Speed of activation Magnitude of response Time to return to baseline Things that affect cortisol response time of day health genetics personality early pre-natal/childhood stressors- epigenetics can change DNA expression current stressors smoking if female- where you are in cycle or use of OCP interaction with testosterone Sensation of psychological stress is not always associated with physiological stress (i.e. cortisol stress response) Conversely in psychological studies in which subjects get exogenous steroids (i.e take a hydrocortisone pill) although there are often associated behavioral changes from the steroids participants rarely feel anxious. Somewhat ironic that women report more psychological stress but that men die on average 7 years earlier Things that reliably trigger physiological stress:  Demands >>> Resources Unpredictability Uncontrollability Novelty Learning on stress is U shaped curve A little stress helps things stick more As stress increases harder to draw  Some suggested sex differences: In general women have higher baseline HR than men (despite this, women are believed to have a higher parasympathetic baseline tone) Triggers: Men may be more vulnerable to stressors that trigger dominancy/hierarchy Women may be more vulnerable to stressors that trigger social isolation Free Cortisol is the active form and men appear to have higher free cortisol levels Women may be more sensitive to acth- similar cortisol level with less trigger. Men more likely to respond to threat of hierarchy, women social exclusion Stress resiliency: Time to respond, magnitude of response time until return to baseline To what, how quickly, how much, how long.  Studies discussed in podcast Alexander, G. M., Wilcox, T., & Woods, R. (2009). Sex differences in infants' visual interest in toys. Archives of Sexual Behavior, 38(3), 427–33. https://doi.org/10.1007/s10508-008-9430-1 Ali, Amir; Subhi, Yousif; Ringsted, Charlotte; Konge, Lars. Gender differences in the acquisition of surgical skills : a systematic review. /I: Surgical endoscopy, Vol. 29, Nr. 11, 11.2015, s. 3065-3073. Deane, R., Chummun, H., & Prashad, D. (2002). Differences in urinary stress hormones in male and female nurses at different ages. Journal of Advanced Nursing, 37 , 304–310. Shane MD, Pettitt BJ, Morgenthal CB, Smith CD (2008) Should surgical novices trade their retractors for joysticks? Videogame experience decreases the time needed to acquire surgical skills. Surg Endosc 22:1294–1297 Theorell Tores, On Basic Physiological Stress Mechanisms in Men and Women: Gender Observations on Catecholamines, Cortisol and Blood Pressure Monitored in Daily Life. Psychosocial Stress and Cardiovascular Disease in Women, DOI 10.1007/978-3-319-09241-6_7  Published 2015 pp 89-105 Turecki, G., & Meaney, M. J. (2016). Effects of the Social Environment and Stress on Glucocorticoid Receptor Gene Methylation: A Systematic Review. Biological Psychiatry, 79(2), 87–96. https://doi.org/10.1016/j.biopsych.2014.11.022  Yael, Sofer, et al. "GENDER D. S. F. C. H. L. I. M. . E. P. (2016). (2015). Original Article GENDER DETERMINES SERUM FREE CORTISOL: HIGHER LEVELS IN MEN EP161370.OR. Endocrine Practice. https://doi.org/10.4158/EP161370.OR  White MT, Welch K (2012) Does gender predict performance of novices undergoing fundamentals of laparoscopic surgery (FLS) training? Am J Surg 203:397–400  

For the 30 years, clinical understanding of haemodynamic resuscitation has been based on physiological paradigms that focus on convective oxygen delivery. Most of these emphasise the role of cardiac output, haemoglobin and recommend interventions using synthetic agents such as dobutamine, synthetic colloids and blood transfusions. Markedly influenced by industry, these interventions and strategies hijacked critical thinking creating a belief in the utiliity of attaining short-term physiological surrogates for resuscitation that have little relevance in improving patient-centred outcomes. This 'physiological fallacy' has been demonstrated in high-quality RCTs of fluids, goal-directed therapy and catecholamines, that paradoxically inform the interpretation of new insights in the physiological basis of health and disease.

SMACC Back 1 on Catecholamines

John Myburgh brings his experience and analysis to bear upon the use of catecholamines in the crashing patient. The second talk in the Resuscitation plenary.

The actions of the reductant ascorbic acid on rat neocortical neurons in vitro was investigated by means of intracellular recordings. At a concentration (500 μM), which reduced the magnitude of dopamine degradation in oxygen-saturated saline solutions by about 50%, ascorbic acid reversibly depressed synaptic potentials and enhanced direct excitability of cortical neurons. The latter effect was not reversible within the observation period. Ascorbic acid did not alter membrane potential and input resistance of the neurons. On the basis of our results we conclude that ascorbic acid is not a useful reductant to avoid oxidation of catecholamines in oxygen-saturated solutions used in electrophysiological experiments in vitro.

Plasma catecholamines and circulation parameters were studied in a patient with a Shy-Drager syndrome. Basal values of free noradrenaline and dopamine were within the normal range, whereas the adrenaline level was decreased. The response of plasma catecholamines to different kinds of physical activity was pathological. The inability to maintain elevated catecholamine levels during prolonged activity corresponded to impaired circulatory regulation and may provide an additional tool for diagnosis and monitoring of the Shy-Drager syndrome.