Podcasts about Tiron

As always around the end of the year I gotta pull up and talk about music. For this episode I cover thirteen under rated albums that were released in 2024. Make sure you go check out my blog version of this topic on Medium so you can listen to the songs I recommend from each album. All relevant links will be in this description. Hope you enjoy! Albums listed 1. I.F. (Chuuwee & Imaginary Other) - NxBodies 2. Tiron & Ayomari - The Adventures Of Tiron & Ayomari 3. Amaka. - how's your head? 4. Ty Farris - Enigma With An Attitude 5. K.A.A.N. & DJ Hoppa - In Due Time 6. Immortal Girlfriend - Soujourner 7. Onra - Nosthalgia 8. GAWD - Cathedral City Supreme 9. Ilajide & Def Dee - Tape Delay 10. Cunninlynguists - The Heartstring Theory (Part one) 11. Anna Field - Medicine 12. Joel Q - Project Summer 13. Smooth Haynes - Vainglorius Follow me on Medium - https://medium.com/@cerealsensei410 Follow me on Twitch - https://www.twitch.tv/cerealsensei Follow me on Twitter - https://x.com/CerealSensei Follow me on Bluesky - https://bsky.app/profile/cerealsensei.bsky.social

0:00:00 Introducere și prezentarea expertului în baterii auto00:05:25 Percepții greșite despre mașinile electrice: Mituri demontate00:15:40 Anatomia bateriilor: Inima mașinilor electrice explicată00:31:25 Hibrid vs. Plug-in Hybrid vs. Full Electric: Avantaje și dezavantaje00:48:10 Probleme comune la mașinile electrice și costurile de reparație01:02:35 Analiza fiabilității mărcilor: Cine produce cele mai bune mașini electrice?01:20:15 Baterii uzate: Opțiuni de reciclare și reutilizare01:39:40 Viitorul industriei auto: Electric sau combustibili sintetici?01:55:20 Diagnosticarea bateriilor: Proces, echipamente și costuri02:01:55 Sustenabilitatea mașinilor electrice: De la producție la reciclare02:07:30 Sfaturi pentru cumpărători: Cum alegem mașina electrică potrivită02:12:45 Concluzii și perspective asupra viitorului mobilității electrice IGDLCC înseamnă Informații Gratis despre Lucruri care Costă! Totul ne costă dar mai ales timpul așa că am făcut această serie pentru a mă informa și educa alături de invitați din domeniile mele de interes. Te invit alături de mine în această călătorie. Mi-am propus să mă facă mai informat și mai adaptat la schimbările care vin. Sper să o facă și pentru tine.

Cosmic Cuts lives in the primordial soup of hip hop, boom bap, electronica, soul and Rnb. Vibe with us for our 8th annual 420 celebration curated by @djunjust ! Unjust recommends you turn the volume up, dim the lights, and savor the present. This episode is meant to be a blunt for the soul (no green required but it is known elevate the experience). Recorded live in Nairobi for Low End Theory Kenya! Should out to @basthma-1 and The Mist! artist - track VRSYJNES - Feel My Fye ft. Amber London & Dough Amber London - Remember Amber London - Nebula Smino - Mr. Pinterest RIZE - Niko Eazeh (ft Steph) Styles Davis - betigotsumweed SiR - Rapper Weed ft Boogie tg.blk - gin and wine Ari Lennox - Backwood mac miller - Diablo tg blk - NYDFRYSTL mxxwll - SMOKE W U lojii - $till Potatohead People - Last Nite ft Redman Blu & Shafiq Husayn - Roll Up (ft Jimetta Rose, Donel Smokes, and Tiron) dr.Oop and The Red, Gold & Green Machine - The Look Of Love segal syrup slowdown Holly Cook - beat goes on dub Lee Scratch Perry x Yaadcore x Green Lion Crew - Green Brain (Subatomic Sound System Vocal Remix) Little Simz - Two Worlds Apart (S!RENE Edit) femi kuti - Bad Man Lighter (Remix) ft Black Thought Wakadinali - Mariwana Just Imagine Africa - BANGI Simen Sez - 420 >> whatevever it takes YDK WHY (buju, wayne wonder + austin millz) I got 5 on it g-funk edition

Realizatori: Ionuț Dulămiță, Mihai Lukàcs, Paul Breazu ==================================== Ce poate să fie după apogeu? Cum se dezvoltă orașul? În ce s-au transformat sălile de repetiții? Cu ce a rămas Timișoara? Ce s-a pierdut în timp? Cum era Timișoara în muzică în anii ‘80? Cât timp a avut Timișoara dominație otomană? De ce era, pentru turci și austrieci, o catastrofă să fii trimis la Timișoara? Ce înseamnă să fii la periferie? Cât timp a fost Timișoara capitala Imperiului? De ce apare în Timișoara desantul rockist de la sfârșitul anilor ‘60? Care era avantajul pe care îl avea Timișoara? Cum intra muzica din Occident în România? Există un sound timișorean al rockului? Cine a dat identitatea rockului românesc? Ce film i-a tușat iremediabil pe Nicu Covaci și Ilie Stepan în anii ‘60? Ce trupă maghiară îl face pe Ilie Stepan să înțeleagă că Republica Populară Ungară construia un alt fel de socialism? Sunt subculturile subversive de rock specifice în Est? De ce îi apreciau hipioții și pe Lenin, și pe Lennon? Ce putea fi folosit de la punkiști și rockeri pentru resuscitarea socialismului? Răspunsurile le aflați numai din Arhiva de Sunet: Timișoara, episodul 1. ==================================== Vorbesc, în ordinea apariției: Ionuț Dulămiță (Arhiva de Sunet), Horațiu Hot (ex-lider OSUT), Octavian Horvath (muzician, Implant Pentru Refuz), Pacha Man (muzician), Adriana Babeți (scriitoare), Ștefan Tiron (curator), Paul Breazu (Arhiva de Sunet), Doru Rocker Ionescu (jurnalist), Ilie Stepan (muzician, Pro Musica), Mimo Obradov (jurnalist), Emanuel Copilaș (sociolog) ==================================== Muzică: Pacha Man, „Același sânge” (muzică: Junior Reid, Pacha Man, text: MoWeed, Pacha Man, Nova Music Entertainment/Rebel Music, 2003) Genius, „În orașul trist” (muzică: Genius, text: Genius, East & Art, 1998) Pavilionul 32, „Timișoara”, (muzică: Pavilionul 32, text: Kleshta, Gluga Neagră, 2005) Metamorf, „Autostop”/ https://www.youtube.com/watch?v=rHrb9BTogKA Cliff Richards and The Shadows, „The Young Ones” (muzică și text: Sid Tepper și Roy C. Bennet, Columbia, 1961) Karussell-Band Freiburg https://www.youtube.com/watch?v=VUwZaDHkB20 Omega, „H. Az Elektromos Fűrész” (muzică: Molnár György, Qualiton, 1970) Phoenix, „Pseudo-Morgana” (muzică: Nicolae Covaci:, Electrecord, 1972) Phoenix, „Canarul” (muzică: Florin Bordeianu și Nicolae Covaci, Text: Victor Șuvăgău, Electrecord, 1968) ==================================== Echipa Arhiva de Sunet: Paul Breazu, Ionuț Dulămiță, Mihai Lukàcs Editor audio: Cătălin Matei Comunicare: Textual Media Jingle: Coughy, „Precambrian” ==================================== Parteneri media: Radio România Cultural, Radio România Timișoara, RFI, IQAds, Scena 9, Vice, Cultartes, Decât o Revistă, Un site de muzică, Cooperativa Urbană ==================================== Mulțumiri speciale: Universitatea de Vest din Timișoara, Librăria La Două Bufnițe, Londohome ==================================== Arhiva de Sunet: Timișoara este un proiect al Centrului Dialectic și este realizat cu sprijinul Primăriei Municipiului Timișoara și al Consiliului Local Timișoara. Proiectul cultural nu reprezintă în mod necesar poziția Primăriei Municipiului Timișoara și a Consiliului Local Timișoara. Conținutul proiectului cultural și modul în care rezultatele acestuia pot fi folosite reprezintă responsabilitatea exclusivă a autorilor și beneficiarului finanțării. Primăria Municipiului Timișoara și Consiliul Local Timișoara nu sunt responsabile pentru conținutul materialului și modul în care acesta ar putea fi folosit.

In this episode, we talk to the cast of Star Trek: Deep Space 9: James Darren "Vic Fontaine", Jeffrey Combs "Weyoun, Tiron, Brunt", Casey Biggs "Damar", Chase Masterson "Leeta", Max Grodenchik "Rom", and Cirroc Lofton "Jake Sisko" about their favorite roles, moments, and costumes. Not to mention, audience questions! 13:52 – Is there anything from Trek that still influences you to this day? 19:11 – What has been your favorite role to date? 23:35 – What was the most challenging technobabble line that you had to learn? 26:48 – What series have you currently been binge watching? 29:37 – What skill or technique have you recently mastered in your career? 32:59 – If you were to return to Star Trek but in a new role, what would you want? 36:27 – What is a dream role in general for each of you? 39:29 – Who was your favorite guest star on DS9? This discussion was moderated by Patty Jenkins and originally aired live on galaxycon.com on August 7th. Head over to check out more FREE livestream Q&As!

On episode #45 of Ambrosia For Heads' What's The Headline, we lay out the evidence for why Kendrick Lamar is releasing new music this week, debate Nas and JAY-Z's verses on "Sorry Not Sorry" and more: 0:00 Intro 1:00 TDE's Top Dawg Posted “The Wait Is OVAH!!!!!!” on social media 2:00 Which artist—Kendrick Lamar, Isaiah Rashad, SZA or someone else—is releasing new music 3:20 The AFH team is divided, so they make a wager on whether or not new Kendrick Lamar music is coming on May 7 7:40 An argument for why it will be Isaiah Rashad or SZA music 14:20 A history of TDE's surprise album release strategy 31:49 The mountain of evidence that suggests new Kendrick Lamar music is coming on May 7 42:52 Kendrick Lamar's new music may have been recorded in the Death Row Records studio where Tupac recorded 45:50 A review of DJ Khaled's “Sorry Not Sorry” featuring Nas and JAY-Z 47:40 Nas and JAY-Z do not rap their best verses when they are on the same song together 49:00 The substance of Nas and JAY-Z's verses on “Sorry Not Sorry” is more important than the quality of the verses 55:50 Nas and JAY-Z are still competing with each other on many levels 1:01:14 DJ Quik says he wants his credit for his work on Nelly's “Hot In Herre,” Kendrick's “King Kunta,” Tupac's All Eyez On Me & more 1:09:24 Every song Kendrick Lamar's DAMN has been certified at least gold 1:11:08 Talib Kweli & Hi-Tek are making a new, third Reflection Eternal album 1:16:28 New music of the week: J. Period, Tiron & Ayomari and more --- Support this podcast: https://anchor.fm/whats-the-headline/support

We interview Tiron Manning, Founder of Newcastle Buyers Agent. We chat to him about what he has noticed from a gentrification point of view, he points out what you need to spend to secure an investment in the Newcastle area, he gives us some great advice for investors looking for their next property and we talk about the role of a Buyers Agent in general.

Originally released: February 2018. Special gives you all the latest music in just 5 minutes! Special on Twitter: Twitter.com/SpecialSays Tracklist: 1. Ill Camille- Fight On (Heirloom out now) 2. TiRon & Ayomari- Politics As Usual (The Wonderful Ego Trip out now) 3. Latasha Alcindor- Glo Up (Teen Nite At Empire out now) 4. Sango & Xavier Omar- Sweet Holy Honey (In The Comfort Of out 3/16) 5. Gifted Gab & Blimes Brixton- Come Correct 6. Ravyn Lenae- Sticky (Crush out 2/9)

On the heels of Creation Entertainment announcing the Official Star Trek Convention being moved to December 9-13, 2020 to Caesar's Form in Las Vegas, NV, we got a chance to speak withCasey Biggs (Damar, Dr. Wykoff) and Jeffery Combs (Weyoun, Brunt, Officer Mulkahey, Tiron) are the hilarious duo from Star Trek: Deep Space Nice that are ready to answer your questions as they take part in Creation Entertainment’s Virtual Van Experience on Saturday, May 16, 2020 at 10:15 a.m. PT. where fans can join in via a “Pay What You Can” by signing up by lick here at StageIt. The highest supporter will receive a 1-0n-1 Zoom Meet-and-Greet with Biggs and Combs and Creation Entertainment Swag Bag valued at $100! We caught up with the duo to discuss this weekends events and how after 25 years since Star Trek: Deep Space Nine has gone off the air they retained their closer friendship, how what was science fiction on the series has now become science fact and playing a part in such legacy franchise.. Note: Tipping must be completed BEFORE the end of the panel. Tips made after the panel is over cannot be counted towards “Top Tipper” prize. Winner will be contacted immediately following the panel. Please make sure your information (phone & email address) is included in your StageIt profile. Along with this Pay What You Can event, there will be an auction with the opening bid at $50, where the 10 highest bidders will have a more intimate Zoom meeting with Biggs and Combs on Sunday, June 7, 2020 at 10 a.m. PT. Click here to start your bids!

Originally released: March 2018. Special highlights all brand new music for you! Special on Twitter: Twitter.com/SpecialSays Tracklist: 1. Flatbush Zombies ft. Dia- U&I 2. TiRon & Ayomari ft. TheeKidSpex! & Nonchalant Savant- Palo Santo 3. Zyah Belle- Alright Bet 4. Drew Banga ft. 1-O.A.K., YMTK, Wade.08 & Amen- Multi Color 5. Curren$y- Pegasus Remix 6. J. Sirus ft. Kohzi- Lonesome 7. April + Vista- How To Get By 8. DJ Flow & Mani Draper ft. IAMSU- New God

In episode 450, Miles and special guest host Laci Mosley are joined by comedian Pallavi Gunalan to discuss Shaq's weird pizza ideas, Beyonce taking the Smithsonian by storm, Mitch McConnell versus AOC, the Joaquin Castro Trump donor list, how to get seagulls to leave you alone, the avocado-squash scam, and more! FOOTNOTES: 1. Papa John’s newest Shaq-backed innovation is pizza… folded in half 2. Beyoncé's next appearance? The Smithsonian’s National Portrait Gallery 3. McConnell Campaign Responds to Viral Photo of Alexandria Ocasio-Cortez Cutout Being Groped 4. Holy shit. On Fox & Friends, Donald Trump Jr compares the list Joaquin Castro released of public info about who has donated to Trump with a mass shooter's kill list. 5. Scientists may have discovered how to get asshole seagulls to leave your food alone 6. Rising avocado prices force devious restaurants to thin guacamole with squash 7. TiRon & Ayomari - 2 Petty Learn more about your ad-choices at https://news.iheart.com/podcast-advertisers

"I don't have a bio man" Follow TURNA: Soundcloud: https://soundcloud.com/turna_music Facebook: https://www.facebook.com/leftandrightmcr Instagram: https://www.instagram.com/turnamusic Tracklist: Marvin’s Speak Easy - Tall Black Guy luvvvtapsss - Wavy Bagels blow the whistle - j.robb Happy - Ashanti (TURNA Flip) If I Ruled the World (flip) - Pasquinel Toast (remix) - Full Crate x Koffee All That’s Good (Instrumental) - TURNA Estrelar - Marcos Valle Can’t Give Up On You - Children of Zeus (GREGarious Remix) Burna Boy ‘Pop Ye Collar’ (Vandalized Edit) - Jarreau Vandal You Don’t Have to Call - Usher (Malandro Edit) High Hopes - SOS Band Control - JR JARRIS ft. Dayla Roses - Outkast (Panda Remix) Beauty and Essex - Free Nationals (Daju Flip) Let It Go Ft. TiRon & Ayomari - JR JARRIS Wow - Post Malone (TURNA Flip) Do You? - Hae. She Feat Barney Artist - El. Train IN UR ARMS w stripess - IAMBZAR

Welcome to episode 210 of The Future Beats Show Thank you for listening, enjoy Stay connected ➤ Facebook.com/DjComplexion | Twitter.com/Complexion | instagram.com/Complexion Onra - TFBS Intro 2 Twenty Weeks - Pussy Iambzar - Mac Miller - Ladders (Iambzar Remix) Stripess - Feelslikesummer W/ Sheki. West1Ne - Splinter Jr Jarris - Let It Go Ft. Tiron & Ayomari Hans - Aug 5 2018 - Taste Expand Or Expire. - Daju - Me Nd U Aaron Brockovich - Yours West1Ne - Marvins Room Budgiefirebeats - Anything Terrxnce Jordxn - Garden Kisses Samsin - Sancutary Chromecrowns - "After The Love, Is Gone !" Twenty Weeks - I Guess So Krs. // Joanna Esta. - Kay Franklin - Getaheadhouse Edit Chromecrowns - "L O W , L I F E" *V I P* Louis Futon Beats - Everybody Loves The Sunshine Lvusm - 2 On Wavy Bagels - U Go Ttt A Kn O Www Snctm. - Saoirse. W/ Heine Aabφ Gustav Gustav - Lushh Sango - Bollywood Drake Vhoor - Last For Her Toolbox - There's Room For All Of Us Here (Feat. Miki Rose) Joe Nora - Cat Goes Moo W' Sxmniak Sptmbr Yngstr. - Dazed. Ijok. - Soulshaper Montea - Butta Pink Sweat$ - Honesty (Tastebreakers Flip) Pirlew - What Could've Been Sans+ - Money To Blow Mitch Geist - Amoco Freestyle Decap - Who's There?! Sptmbr Yngstr. - I've Loved, I've Lost. Yugi Boi - Coolin W/ Edp & Oxthemoron Oj. - Neon Bounce Cozy Kev - Summer W/ Roto Zodivk - Cpr (+) Coastal - Juiced Kmb - Blossom Sango - Bollywood Drake

Welcome to episode 208 of The Future Beats Show Thank you for listening, enjoy Stay connected ➤ Facebook.com/DjComplexion | Twitter.com/Complexion | instagram.com/Complexion Onra - TFBS Intro 2 Andrasandra - Monopoly Esta. - Kay Franklin - Getaheadhouse Edit Terrxnce Jordxn - Garden Kisses Austinmarc - Run Right Thru West1Ne - Nympho Jr Jarris - Let It Go Ft. Tiron & Ayomari Hans - Aug 5 2018 - Taste Esta. - Vtg Moonmelt - All I See Is You (Ft. Brianna Rose) Up. - Aaron Brockovich - Luvallnight Vhoor - Last For Her Kayloo's Attic - J - Rican - Complete (Kayloo Remix) Devin Morrison - With You Feat Joyce Wrice Montea - Stu Had A Patio Fax Mercury - Na Boca Do Grande Kaelin Ellis - Twentyone Axian - Mischief Potsu - Tell Me Stripess - Here W/ Divya Kokio - Daydream. Tomcbumpz - Time Lapse (W/ Sayso !) Laxcity // B-Sides - Hey Kaytra Tomcbumpz - Butterflies In My Stomach Alsojay.. - Alone_ 7/6/18 Daehan (대한) - Sicko Mode Twuan - Chase Squid Ethics - X Jhfly $Outh$Ide - $Outh$Ide - Ufo Twuan - Turn Off The Light Seneca B - Flowers Shy Cope - Blurry Malik Bawa. - Consideration Chillhop Music - Shy Cope - Drive Home Tomcbumpz - Shot In The Dark Neon Lights (Yxe) - Blessed (Live) J.Robb - Twenty4 Ok2222 - Im Feeling Sad So I Made A Sad Song Sugiwa - Ctrl. T Y M K - C A L L Parkinson White - The Meadows Heine Aabφ - 8/08 Twenty Weeks - Pussy Stripess - Feelslikesummer W/ Sheki. Xo Sad - Ocean Eyes

Ya no sabe si Solari causa risa o admiracion con su actitud. Tiron de orejas en Cruz Azul y cada vez queda menos tiempo para el Real Madrid-Barcelona.

TIRon & Ayomari join us for another episode of "Fun With Dumb" - A new weekly podcast showcasing musicians, comics, artists, actors, k pop stars, chefs, and people from all walks of life! Learn more about your ad choices. Visit megaphone.fm/adchoices

TiRon & Ayomari are both singers, songwriters, and emcees, representing Los Angeles, CA. They have received tremendous recognition by media outlets from Complex to RapGenius, and XXL, to LA Weekly, and The Source. We will be talking about their eclectic and melodically rich album titled, “WET: The Wonderful Ego Trip”.

Back for Episode 94 of Elite Muzik Radio, DJ Eternity puts together a 46 minute mix of Dance-floor edits and smooth R&B cuts.Episode 94 setlist.Picnic - Sunshine - [Roy Ayers Flip]SMOOTH OPERATOR 3000 — Movidabrent faiyaz dancey stuffNya Lee - Hot Lee (wntr club edit)Jaël - SangrooveEKANY — That's Not Memr. alexis — make my day shawtycay caleb. — don't want you on my mind. (jorja smith edit)TiRon & Ayomari — Superhug feat. James FauntleroyZyah Belle — Show You (Moonchild “Cure” Flip) feat. P. Blackk Golden (BlaaqGoldRemix)Claire Reneé — Why You Watchin Me (Produced by K, Le Maestro)T. Hemingway — Hudson.AbJo San Clemente (K - Wash Remix)I Am /dexterbrandon/ - Dior 999LoVibe. — settoff .LAKIM — whendoe - shoppaK, Le Maestro — HATIN ON ME?!Subscribe to Elite Muzik RadioThis podcast is powered by Pinecast. Try Pinecast for free, forever, no credit card required. If you decide to upgrade, use coupon code r-1aea92 for 40% off for 4 months, and support Elite Muzik Radio.

TiRon & Ayomari discuss their earliest days making music, being around for LA's musical renaissance, personal and creative growth over time, Musiq Soulchild, Stevie Wonder, and their new album “WET: The Wonderful Ego Trip”

Episode 12 topics: Finding quality alt. R&B amidst the oversaturation of the genre, Morgan Geist’s imprint on dance music, and the relevancy of the boom bap beat in 2017. Music by NSTASIA, TiRon & Ayomari, Metro Area, and Mick Jenkins.Download Your browser does not support the audio element.

In a music industry driven by fitting the mould, TiRon & Ayomari defy easy categorization. Not exactly hip-hop. Not quite R&B. Ditto for indie and pop music. In the midst of this landscape of carefully-curated brands and genres, of target audiences and defined demographics, the Los Angeles-based duo’s music raises a question: can one be … Continue reading TiRon & Ayomari: “Life is too short to worry about getting it wrong” →

In a music industry driven by fitting the mould, TiRon & Ayomari defy easy categorization. Not exactly hip-hop. Not quite R&B. Ditto for indie and pop music. In the midst of this landscape of carefully-curated brands and genres, of target audiences and defined demographics, the Los Angeles-based duo’s music raises a question: can one be … Continue reading TiRon & Ayomari: “Life is too short to worry about getting it wrong” →

“Sometimes you need to lose who you think you are so you can rediscover who you are.” Welcome to Kankakee, IL, at one time ranked the worst city in the U.S. Growing up moving around a lot, with little dreams of a big city, TiRon found himself getting lost in creativity as a way to escape the world around him. He was always drawn to music - not to any genre, but to how it made him feel. His natural curiosity for people and experiencing new things was his way out of his small town, and his mind… Welcome to South Side Chicago, where gangs and violent crimes were at an all time high. But as kids, we don’t always have a concept of danger. For Omari, this was simply his neighborhood, like any where else. Inspired by his loving mother, she introduced him to music at an early age, from Tina Marie to Masta P. But where Omari really got lost was in his drawings and passion for art. Both kids were receptive to the world around them, yet so different how they ingested it. It wasn’t until TiRon moved to LA where his thought was challenged, and he got his own identity. He always wrote and recorded songs, but it was the stage that allowed him to “lose his mind”. For Omari, his drawings would soon turn into writings, and those writings would turn into lyrics. Music was infectious, and it was a matter of time that this new path would lead the way. From online chatrooms and message boards, to bringing a community together to push the culture forward, there’s a very real force you feel when these two brilliant minds come together. You can call it vulnerability, creativity, or authenticity. Or you can just call it freedom. But this is a story about something that gives us purpose, and fulfillment. This is TiRon & Ayomari. #MamaWeMadeItConnect!IG: @tironandayomari@goronnie@ayoayomari@mamawemadeit@anoushmoin@getrauschymamawemadeit.com See acast.com/privacy for privacy and opt-out information.

Health Story Collaborative Podcast Episode 5: Tiron’s Story (Originally aired on the WBUR Commonhealth Blog). In this segment, we hear from Tiron, whose wife, Marie, was featured in our last episode. Marie was diagnosed with Stage IV colorectal cancer in 2007 at the age of 45, and lived bravely with the disease for nine years. In December of 2016, the cancer took her life. In this episode, Tiron offers his perspective on the challenges of marriage and parenting amidst chronic, and ultimately fatal, illness. He demonstrates tremendous flexibility in adjusting to his “new normal,” the new responsibilities and new expectations for the future brought about by his wife’s diagnosis. This podcast is a product of Health Story Collaborative, a nonprofit organization dedicated to harnessing the healing power of stories. To learn more about Marie’s story, and to find resources on colorectal cancer, please visit http://healthstorycollaborative.businesscatalyst.com/audio_stories/marie-living-with-cancer. Music by Jack Broza Lawrence, www.jackbroza.com.

Welcome to another edition of PoPolitickin. In this episode, we politick with Oakland/Portland artist TOPE. Producer / Rapper TOPE is considered one of the top up and coming artists in the Northwest region and has been recently featured on XXL, The Source, 2DopeBoyz, Okayplayer, Jay-Z's Life + Times, Hip Hop Wired, Hip Hop DX, and more for his album latest BROKE BOY SYNDROME. Since his debut album in 2010, TOPE has produced and/or collaborated with artists including Slum Village, Blu, Planet Asia, TiRon, Myka 9, Abstract Rude, Scarub of Living Legends, LMNO, and many many more. With a commanding stage presence and engertic live show, TOPE has shared stages with hip hop legends including Nas, Mobb Deep, Talib Kweli, Run The Jewels, Deltron 3030, Big KRIT, Dom Kennedy, Black Milk, Mac Miller, Ty Dolla $ign, Digable Planets, Hieroglyphics, Aesop Rock, The Coup, People Under The Stairs, Macklemore and countless others. In early 2014 TOPE also gained attention from Soul icon Erykah Badu herself for his TAKE YOUR TIME video. Follow TOPE on social media at @itsTOPE Follow Po on social media at @PoPolitickin

MC Melodee, Liana Bank$, Phil Adé, BOAZ, Willie The Kid, Skyzoo, Sean Price, Julian Malone, Tiron & Ayomari, and much more.Full track list available on our website www.indiecreativenetwork.com

Special Sundays April 21: Tiron & Miguel- "Go" Clear Soul Forces ft. Idris Elba- "Gotham City" Ghostface- "Chez De La Ghost" Dom Kennedy- "Choose Up" Ru- "Master Plan Remix" Jay Electronica ft. Jay Z & The Dream- "Shiny Suit Theory" Sene- "Cult Classic" DLRN ft. Prometheus Brown & Illecism- "Reset" Ann Pebbles- "I Can't Stand The Rain" Missy Elliot- "Supa Dupa Fly" Audible Doctor ft. Von Pea- "F.U.B.U." Vanessa Marquez- "In The Midnight Hour" Pharrell x Daft Punk- "Get Lucky" The Weekenders (Chuuwee, Bam Circa 86, Real J Wallace, PCH & Abjo)- "The Afternoon" "We Don't"- Zion I ft. Eligh & The Grouch Jhene Aiko- "3:16am" J. Dilla ft. Common & D'Angelo- "So Far To Go" Fashawn- "Boy Meets World" Keno- "Without You" Ghost Town DJ's- "My Boo" Rapsody ft. BJ The Chicago Kid- "Good Good Love" Bambu- "Coffee In My Left" Actual Proof- "We Gon Continya" Clipse ft. Ab-Liva- "Blaze Of Glory" Tyler ft. Frank Ocean- "Bimmer" J. Cole- "Hold It Down" Jarell Perry- "If It Ain't Too Late" Biggie ft. Carlitta Durand- "One More Chance (Woody Remix) Jasmine Nichol- "The Infusion Of Lover's Hearts" Jansport J- "Go!" Feedback? @SpecialSays or SpecialSundaysRadio@gmail

April 3: J. Good & J. Lately ft. Co$$ (Prod by Jansport J)- "Runnin' On Empty" LA- "LaLaLand" Audimatic- "The Wolves" Trek Life ft. Hawdwerk & Bishop Lamont- "Rap Time" Melanie Fiona- "Bad" Yasiin Bey & Mannie Fresh- "Black Jesus" Tiron & Ayomari- "PRTY N BLSHT" Amp Live- "D.H.E.A." www.SpecialSays.com Feedback? @SpecialSays or SpecialSundaysRadio@gmail.com

Special Sundays March 30 on Juice Radio: Fly Union ft. BJ The Chicago Kid & Pac Div- "Do It For You" Big KRIT ft. Grillade- "Neva Go Back" DLRN ft. Hopie- "Grapevine" Koncept ft. Tanya Morgan- "Space Mountain" Kanye West ft. Mos Def, Lupe Fiasco, & Big Sean- "Don't Look Down" Signif- "Rocket Fuel (PCP)" Keno ft. Chuuwee- "The Cold" Murs & Fashawn- "Slash Gordon" Ab-Soul ft. Danny Brown & Jhene Aiko- "Terrorist Threats" Tiron & Ayomari- "No Filter" Bam Circa 86- "*Peace" Denetia & Sene- "Lucy, Loosie" Rapsody- "Celebrate" J. Lately ft. Zumbi & Deuce Eclipse- "Energy" Erykah Badu- "On & On" Levi Watson- "Zero One" A Tribe Called Quest ft. Busta Rhymes- "Oh My God" Nametag & Nameless- "Buggin" The Holy Order- "The Holy Order" Ruby Ibarra- "LIT" Clear Soul Forces & Kooley High- "Freq Freq" Thurz ft. Black Thought- "Riot" Phonte ft. Pharoahe Monch- "We Go Off" C- Plus- "Ice Cream" Quelle- "The Retrograde" Red Pill & Hir-o- "The Kick" MF DOOM- "Doomsday" 2 Player Co-Op (Trackademicks & 1OAK)- "How Soon Is Now" Blu ft. Miguel- "First Things First" Groove Theory- "Tell Me" www.SpecialSays.com www.GoJuiceRadio.com Feedback? @SpecialSays or SpecialSundaysRadio@gmail.com

Bedos is on the horizon and Spring will soon follow. NouGold is here to pimp-slap some of that underground hip hop goodness back in your faces, for the second time in 2013. This month we have a WORLD EXCLUSIVE track from TASK1ne, Mad Flows & Dibia$e, plus a truckload of incredible hip hop vibes. http://nougold.co.uk http://facebook.com/nougold http://twitter.com/nougold NouGold on iTunes: https://itunes.apple.com/gb/podcast/nougold/id462734566 Track listing: 01. Big KRIT & 9th Wonder - Reign On (https://www.facebook.com/BigKritMusic) 02. Cheech ft. Dubbul O, Goshin & Legion - Witness (https://www.facebook.com/mothershipconnectionuk) 03. 1995 - J'aime Ca (https://www.facebook.com/undoubleneufcinq) 04. Tiron & Ayomari - No Filter (https://www.facebook.com/pages/TiRon-Ayomari/161971980537691) 05. B. Durazzo - Catacombs (https://www.facebook.com/durazzobeats) 06. TASK1ne, Mad Flows & Dibia$e - In Flight (https://www.facebook.com/TASK1ne) (https://www.facebook.com/mad.flows1) (https://www.facebook.com/pages/MR-DIBIASE/316523046376) 07. Action Bronson - Morey Boogie Boards (https://www.facebook.com/ActionBronsonMusic) 08. MarQ Spekt & Kno - AquaMarine (https://www.facebook.com/pages/Official-MarQ-Spekt/193937180697298) 09. D'Lyfa Riley - Orionbula 10. Versis & Bagir-Ba - Barista (https://www.facebook.com/pages/Versis/162122680523728) 11. City Lights (Uptown Swuite & DJ Flow) - Fly Away 12. Tall Black Guy - Love to the World (https://www.facebook.com/TallBlackGuyProductions) 13. Truthos Mufasa - Groggy Groggier (https://www.facebook.com/TruthosMufasa) 14. Chuuwee - Navigation (Prod. Pete Pine) (https://www.facebook.com/pages/Chuuwee/129216973803112) 15. ANTHM - Low Class (https://www.facebook.com/iamanthem) 16. J LoveLH & K.Murdock - Saturday Night (https://soundcloud.com/jlovelh) 17. Homeless - Settle Down (Remix) (https://www.facebook.com/homelessraps) 19. Slakah The Beatchild - Bare Naked (Freddie Joachim Remix) (https://www.facebook.com/SlakahtheBeatchild) 20. Overdoz X Worlds Fair X Flatbush Zombies - Mood Swings (https://www.facebook.com/OverDozDuh)

Hey there family! As you can see we are now doing new episodes of Soul Siesta Bi-monthly.  Honestly I have been just too busy with so many other projects.  Hope you good people are getting into the swing of spring.  This mix features quite a few new artist that you need to research and buy, buy , BUY their albums, EPs, Mixtapes or a ticket to a show in your town.  Please understand that the purpose of Soul Siesta is to share with you the wonderful work of these singers, song-writers and producers. THANK YOU FOR ALL YOUR SUPPORT.  PLEASE SUPPORT THE ARTISTS FEATURED IN THE MIX... without your support this good music dies a slow death.  Blessings and Guidance. Now for the playlist Artist Song Title Marsha Ambrosius Get You Right (Remix) Eric Roberson She went away (Ezel's Remix) Michael Jackson Rock with You (Ezel's Remix) Zo! Free Your Mind (Feat. Lady Alma) All Cows Eat Grass I'm In Love Marsha Ambrosius Get You Right (Remix) Teyana Taylor Valentine 1-O.A.K. Me & You N'dambi The World Is A Beat [Six7Heat Remix] Karizma Good Morning feat. Monique Bingham (Yoruba Soul Mix) Vikter Duplaix Morning Fun (Feat. Common) Phill Wade Favorite Thangs Dwele Dim The Lights (Featuring Raheem DeVaughn) Dru Carter Runaway Love TiRon & Ayomari You Got It - Ft Iman Omari Median; Phonte; YahZarah; Bahamadia Special  Enves Light Sky Daley Alone Together (Feat. Marsha Ambrosius) Delilah Love Drug ISHE get right!! or get left!! Diggs Duke The Epic Lie Iman Omari Midnight Jaiden "The Cure" Work Of Art Odd Future White (feat. Frank Ocean) Lalah Hathaway My Everything (Applejac's Sounds Of Mecca remix)

One half of the Groovement team, DJ A-UP is also resident at hip hop night In The Loop in Manchester. Listen to DJ A-UP and Bedos monthly on the Nougold podcast, the best of the Nougolden Age of hip hop: http://nougold.co.uk The long awaited second part of DJ A-UP’s mixtape series for Groovement, signalling the arrival of Spring and sunshine… collating the best of independent hip hop (and a few classic sounds) in the way only Nougold can. The first part was one of Groovement’s most popular podcasts, so please share the love on the sequel! 01. Intro / Damu The Fudgemunk – Bright Side Remix 02. Soulful ft. Muggsy Malone & D.O.E. C.I.G.A.P.O.M. – Mumbo Sauce & Drumbreaks 03. 7even Sun & Cans ft. Multi The Chozen – Summer 04. Idasa Tariq – Spend Some Time With You 05. Chuuwee – Here Yee Here Yee 06. OneLove Beats – Lovely Sounds 07. Hollywood FLOSS – Stalker (Prod. Brandun Deshay) 08. M.anifest – Suffer 09. Mr Miranda & Random – Wednesday 10. Mr Dibia$e – Viewfinder 11. Kurtis Stanley – On My Mind 12. Twentynine ft. Lenny White – Morning Sunrise 13. Jun Classic – The Morning 14. Anotha Level - What’s That Cha Say? 15. Blu ft. Planet Asia & Killa Ben – d o o w h o p 16. The Brothers Johnson – Tomorrow 17. Grand Puba – Amazing 18. Kazahaya – The Light (Instrumental) 19. Build An Ark – Bottom To The Top 20. Sean Toure ft. Dionne Wilkins – Life Is Good 21. Late Night Fruit - Marang 22. TiRon & Ayomari ft. Yummy Bingham – All My Love 23. Savant (Stanstro) – Make Your Move (Krash Slaughta Braveheart Remix) 24. Sincere Vega – Big Mac 25. DJ Czarny & Tas – Jazzmatas 26. Blu ft. Jimetta Rose – Spring Winter Summer Fall 27. Clear Soul Forces – Get No Better 28. Versis – Travellin’ 29. L Digz ft. Elizabeth Depasois – Peace of Mind (Prod. Riddle) 30. J Rawls – Face it (Instrumental) 31. Kazahaya – Pianist Love Song 32. The Slakadeliqs ft. Justin Nozuka – Love Controls The Sun

Archive: http://groovement.co.uk DJ A-UP’s first words were “Boom, bap”, and he’s here to restore your faith in hip-hop. Now resident at Groovement-associated live hip hop night IN THE LOOP after serving his years in the now sadly-departed Manchester hip hop institution C’MON FEET, he only plays that good shit. Check DJ A-UP’s mixtape series on Mixcloud here: DJ A-UP 1. Billy Paul – Don’t Think Twice It’s Allright (1968) 2. Fashawn – Samsonite Man (2009) 3. Star Slinger – Mornin’ (2010) 4. Von Pea – Good Life (2010) 5. Shad – Rose Garden (2010) 6. Illecism – Plus Sign Vibe (2010) 7. J Dante X Man Mantis – Hi Love (2009) 8. Revolutionary Rhythm – Los Angeles Times (2010) 9. Bibio – Lovers’ Carvings (2009) 10. Blue Scholars – Big Bank Hank (2011) 11. The Gerald Wilson Orchestra – California Soul (1968) 12. A.D.O.R. – Let It All Hang Out (Pete Rock Remix) (1992) 13. Krispy 3 – On Tempo (’94 Lick) (1994) 14. Groove Theory – Baby Luv (1995) 15. Neneh Cherry feat. The Notoroious B.I.G. – Buddy X (Falcon & Fabian Remix) (1993) 16. Blu – MyBoyBlu (2008) 17. Exile feat. J. Mitchell – Your Summer Song (2009) 18. Break Next Beat – Autum Skies (2010) 19. MeLo-X feat. Jesse Boykins – She is Forever (2011) 20. Plato – Make ‘em Clap (2011) 21. Pulled Over By The Cops feat. Nate Santos – Authority (2011) 22. Jay Lee – I’m Dreaming (2010) 23. DJ King Most – Daylight (2008) 24. Legion & Lemon feat. Eric Clapton – Inside of Me (2010) 25. Danny Drive Thru – Go Slow (2007) 26. The Stuyvesants – Greene Ave. Anthem (2010) 27. TiRon – For Your Smile (2010) 28. Phil Ade – Break Me Off (2011) 29. J.J. Brown – World’s A Stage (2009) 30. BrandUn DeShay – Wish Me Luck feat. Dom Kennedy & TiRon (2010) 31. Omas – Ninethousand90 (2010) 32. A Tribe Called Quest – We Can Get Down (1993) 33. Damu The Fudgemunk – Brooklyn Flower (2010)

Jalapeno Brothers present Good Liquor Cheap Beer Season 2 Episode 3. Subscribe to our Youtube channel! youtube.com/GoodLiquorCheapBeer Good Liquor Cheap Beer is an UNCENSORED online radio-style show hosted by the "Jalapeno Brothers" ( Jo Well & Cee Nario). Season 2 Episode 3 features music by Johnson and Jonson, TiRon feat Blu and Asher Roth, P. Diddy & Bad Boy Records, Jo Well feat. Cee Nario & Markfader, The Rej3ctz, Busta Rhymes, Snoop Dog, Lil Wayne, Timbaland, T-Pain, and Drake. Submit your track, for a chance to be featured on our show, by sending it to GoodLiquorCheapBeer@gmail.com. (Make sure to include "GLCB Submission" in the subject line!) This week the Jalapeno Brothers return for the 3rd episode of season 2 of Good Liquor Cheap Beer... the crew sits down to talk about the NBA All Star Weekend (3 point contest, dunk contest, all star game), The Rock returning, Pro Wrestling, the Carmelo Anthony trade to the Knicks, possible Kings move to Anaheim, and of course good music playing in the background! So kick back, pop a bottle or crack open a can, and ENJOY. Track list for Season 2 Episode 3: Johnson and Jonson - Up All Night TiRon feat Blu and Asher Roth - The Richers P. Diddy & Bad Boy Records - Special Delivery (Remix) Jo Well - Black Mercedes feat. Cee Nario and Markfader The Rej3ctz - Cat Daddy Busta Rhymes - Break Ya Neck Snoop Dogg - I Dont Need feat Devin The Dude & Kobe (Prod by DJ Khalil) Lil Wayne - Watch My Shoes Timbaland - Bounce T-Pain - Hustle Hard Drake - Where To Now Thank you all for the continued support to all of us with our music, whether it be Jalapeno Bros, Jo Well, Jo Well & DJ DviousMindZ, Markfader, Cee Nario, or the Antidotes as a whole..we are currently in the middle of a lot of good projects which we will be releasing very soon so STAY TUNED! ...SUBSCRIBE and please tell a friend if you enjoy! #AntidotesMusic http://jalapenobros.tumblr.com/ youtube.com/GoodLiquorCheapBeer "What we usually do is drAnk!"

"Good Liquor Cheap Beer" Episode 6. Good Liquor Cheap Beer is an UNCENSORED online radio-style show hosted by Jo Well & Cee Nario of The Antidotes. Episode 6 features music by Wiz Khalifa, Kid Cudi, Snoop Dogg, TiRon, Tunji, Ayomari, DJ Dahi, Kidz in the Hall, Kero One, The Antidotes, Talib Kweli, Emanon, and The Roots! This week, DJiamJAM (L.i.R.E./Antidotes) stops by to talk sports, drinks, and entertainment with us as we enjoy some Good Liquor Cheap Beer. On episode 6, we cover MLB postseason action, World Series predictions, Wrangler pulling Brett Favre commercials and the "sexting" allegations, helmet-to-helmet hits and suspensions in the NFL, Jay-Z comparing Willow Smith to Stevie Wonder & Michael Jackson, and Kanye West's new album cover being "banned" on twitter. As always, good music--new and old--playing in the background, so pop open a bottle, sit back and ENJOY. Thank you all for the continued support to all of us (The Antidotes) with our music, whether it be Jo Well, Jo Well & DJ DviousMindZ, Markfader, Cee Nario, or the Antidotes as a whole..we are currently in the middle of a lot of good projects which we will be releasing very soon so STAY TUNED! ...SUBSCRIBE and please tell a friend if you enjoy! #AntidotesMusic ORIGINALLY Published on YouTube at: http://youtube.com/GoodLiquorCheapBeer Tracklist: Wiz Khalifa - Black and Yellow Kero One - Keep it Alive Kidz in the Hall - Drivin Down the Block The Antidotes - Win Win Situation Emanon - Blind Love The Roots - Respond React Talib Kweli - Never Been in Love TiRon feat. Tunji and Ayomari - Quitter (Prod. by DJ Dahi) Kid Cudi - I Do My Thing feat Snoop Dogg

The Six Day War of 1967 was fought between Israel and an Arab Coalition (including Jordan, Syria, Egypt, and Iraq).  Israel used the Egyptian blockade of the Straits of Tiron, the massing of Egyptian tanks against the Israeli border, the Syrian shelling of Galilee fishermen, and the Syrian plan to divert drinking water from Israel as reasons for launching their attack. Operation Focus was the Israeli air campaign, which easily wiped out the air forces of the entire Arab Coalition.  Following Operation Focus was a charge eastward into Jordan's West Bank.  The Israelis quickly captured the eastern part of the holy city of Jerusalem.  At the same time, the IDF charged southwards towards Egypt's Sinai peninsula and Gaza Strip.  The IDF, led by future prime minister Ariel Sharon, quickly dispatched the Egyptian army and conquered the entire Sinai region.  On the Syrian Front, the Israelis charged up the Syrian Golan Heights on Day 5 of the Six Day War and took them.  All four of these regions are still in dispute.  Israel returned Gaza and Sinai, but not the Golan Heights or the West Bank. For more information, read: Military History Magazine (June 2002): Conquering the Golan Heights Dictionary of Battles by David Chandler Military History Podcast is sponsored by Armchair General Magazine

Mild hyperhomocysteinemia is an independent risk factor for the development of coronary artery disease, cerebrovascular disease and peripheral arterial disease. The mechanisms by which hyperhomocysteinemia promotes vascular disease are not completely understood yet. An increasing body of evidence has implicated oxidative stress as being contributory to homocysteine’s deleterious effects on the vasculature. Elevated levels of homocysteine lead to increased generation of superoxide anion in endothelial cells by a biochemical mechanism involving nitric oxide synthase, and, to a lesser extent, by an increase in the chemical oxidation rate of homocysteine and other aminothiols in the circulation. Furthermore, homocysteine has been shown to inhibit the activity of important cellular antioxidant enzymes, like the cellular isoform of glutathione peroxidase or superoxide dismutase, which may contribute to homocysteine’s induced oxidant stress. The resulting increase in reactive oxygen species leads to decreased bioavailability of the endothelium-derived signaling molecule nitric oxide via oxidative inactivation and thereby induces endothelial dysfunction. This seems to play a central role in the molecular mechanisms underlying the effects of homocysteine on vascular function. Hyperhomocysteinemia not only leads to endothelial dysfunction but also promotes the development and propagation of atherosclerotic lesion in atherosclerosis-prone animal models. As the recruitment of circulating monocytes to the vessel wall plays a crucial role in the process of atherosclerosis, the purpose of this study was to examine the influence of homocysteine on the interaction of endothelial cells with monocytes. Exposure of endothelial monolayers to D,L- and L-homocysteine resulted in a time- and dose-dependent increase in adherent THP-1 cells by upregulating ICAM-1 expression on endothelial cells. L-cysteine and D-homocysteine had no effects. This indicates that the stimulatory effect is specific for the naturally occurring L-stereoisomer and rather a biochemical than a chemical effect. The increased endothelial expression of ICAM-1 seems to be mediated by increased activation of the nuclear transcription factor NF-kB, as shown by increased nuclear translocation of NF-kB in homocysteine-incubated endothelial cells. In accordance, inhibition of NF-kB translocation by a synthetic inhibitor Bay 11-7082 significantly diminished homocysteine-induced ICAM-1 expression and adhesion of monocytes to endothelial cells. In addition, incubation of monocytes with D,L- homocysteine and L-homocysteine resulted in significant increase in the number of adhering monocytes to unstimulated endothelial monolayer by upregulating the expression of beta-2 integrins. Furthermore, homocysteine-incubation of endothelial cells and monocytes resulted in a dose-dependent and significant increase in the intracellular generation of reactive oxygen species. In support of the role of increased oxidant stress for the above mentioned effects, treatment of endothelial cells with the superoxide scavengers MnTBAP or Tiron together with homocysteine abolished homocysteine-induced monocyte adhesion, ICAM-1 expression and the nuclear translocation of NF-kB. Incubation of THP-1 monocytes with Tiron abolished homocysteine-induced beta-2 integrin expression on these cells and adhesion to unstimulated endothelial cells. These findings suggest that superoxide anion radicals mediate homocysteine’s effects on endothelium-monocyte interactions. In addition to previous studies that indicated that a significant source of reactive oxygen species in homocysteine-treated endothelial cells might be endothelial nitric oxide synthase, experiments using inhibitors of nitric oxide synthase in THP-1 cells indicated that nitric oxide synthase-dependent generation of superoxide anion also occurs in homocysteine-incubated THP-1 cells. This mechanism may contribute to homocysteine-induced oxidant stress. The information generated from these studies may be helpful in designing intervention strategies aimed at inhibiting the generation of reactive oxygen species in the vasculature that is associated with signaling events of monocyte recruitment and infiltration involved in atherosclerosis.

Die Anpassung der Gewebsdurchblutung an die unterschiedlichen Bedarfssituationen, setzt ein koordiniertes Verhalten der Gefäße im mikrovaskulären Gefäßnetz voraus. Diese Koordination der vasomotorischen Reaktionen im mikrovaskulären Gefäßsystem, ist möglicherweise auf die interzelluläre Kommunikation der Endothelzellen angewiesen. Die Endothelzellen und glattten Muskelzellen der Blutgefäße sind über Gap Junctions gekoppelt, auch eine myoendotheliale Kopplung wird diskutiert. Dadurch können Signale in Form von Ionen (und damit Änderungen des Membranpotentials) oder kleinen Moleküle über solche interzellulären Kanäle entlang der Endothelzellschicht weitergegeben werden. Völlig unbekannt ist aber, ob die Permeabilität dieser endothelialen Gap Junctions reguliert wird. Deshalb wurde in dieser Arbeit untersucht, ob vom Endothel gebildete lokal wirksame Gewebshormone (Autakoide, wie NO und Prostacyclin) die Durchlässigkeit der Gap Junctions beeinflussen. Hierzu wurde in konfluenten Kulturen von humanen umbilikalvenösen Endothelzellen (n=190) die Ausbreitung der Farbstoffe Carboxyfluoresein und Calcein nach Injektion in eine einzelne Endothelzelle in die benachbarten Endothelzellen untersucht. Es konnte gezeigt werden, daß der injizierte Farbstoff tatsächlich nur über interzelluläre Kanäle von einer Zelle zur nächsten gelangt. Diese Kanäle werden von Connexinen gebildet, denn ein Peptid, das das Aneinanderdocken der Connexine verhindert, reduzierte die Ausbreitung des fluoreszierenden Farbstoffs. Daher kann mit dieser Methode tatsächlich die Kopplung der Zellen über Gap Junctions untersucht werden. Die erhobenen Daten zeigen, daß die Anzahl der fluoreszierenden Zellen nach Hemmung der NO-Synthase mit Nw-nitro-L-Arginin (L-NA, 30µmol/L) um bis zu 29% zunahm, während die anschließende erneute Freisetzung von NO durch zwei differente NO-Donoren (SNAP bzw. SNP, 1 µmol/L) die Zahl der fluoreszierenden Zellen wieder auf den Ausgangswert reduzierte oder sogar unterhalb den, der unbehandelten Kontrollzellen senkte. Diese durch NO hervorgerufene Wirkung blieb in Anwesenheit des Hemmstoffes der löslichen Guanylatcyclase ODQ (10 µmol/L) oder der Radikalfänger Tiron und Superoxiddismutase unverändert. Dies weist daraufhin, daß es sich bei dieser durch NO hervorgerufenen Hemmung um einen direkten Effekt von NO handelt, der weder über die Bildung von cGMP noch über eine gesteigerte Peroxynitritproduktion vermittelt wird. Auch eine Hyperpolarisation der Endothelzellen durch den Aktivator von KATP-Kanälen HOE234 (1 µmol/L) hatte keinen Einfluß auf die Kopplung der Zellen. Im Gegensatz dazu hatte NO in Anwesenheit der Hemmstoffe der Tyrosinphosphatase Orthovanadat (100 µmol/L) und Phenylarsinoxid (1 µmol/L) keinen Einfluß mehr auf die endotheliale Kommunikation via Gap Junctions. Dagegen führte die Behandlung der Zellen mit dem Tyrosinkinase Inhibitor Genistein (100 µmol/L) zu einer deutlichen Reduktion der endothelialen Kopplung (-14%), die mit der Wirkung von NO vergleichbar war. Daraus läßt sich schließen, daß die durch NO hervorgerufene Wirkung auf die interzelulläre Kommunikation über eine Verminderung der Tyrosinphosphorylierung vermittelt zu werden scheint. Außerdem zeigen diese Daten, daß Prostacyclin die endotheliale Kopplung signifikant steigert, und das diese Wirkung über das gebildete cAMP vermittelt wird. Denn nicht nur das Prostacyclin Analogon Iloprost (1 µmol/L), sondern auch der Aktivator der Adenylatcyclase Forskolin (30 µmol/L), verbesserte die Ausbreitung des Farbstoffes signifikant . Schließlich zeigen die Ergebnisse auch, daß die beiden vom Endothel gebildeten Substanzen sich gegenseitig in ihrer Wirkung auf die endothelialen Gap Junctions beeinflussen können. Die erhobenen Daten zeigen erstmals eine Rolle von NO und Prostacyclin in der Regulation der Permeabilität endothelialer Gap Junctions. Diese Regulationsmöglichkeit und die Auswirkungen einer vermehrten oder verminderten Kopplung der Endothelzellen wirft zahlreiche neue Fragestellungen auf z. B. hinsichtlich der Pathophysiologie der coronaren Herzkrankheit oder auch des arteriellen Hypertonus und bietet damit auch die Möglichkeit zur Entwicklung neuer Therapiemöglichkeiten.

Hyperhomocysteinemia is an independent risk factor for the development of atherosclerosis. An increasing body of evidence has implicated oxidative stress as being contributory to homocysteines deleterious effects on the vasculature. Elevated levels of homocysteine may lead to increased generation of superoxide by a biochemical mechanism involving nitric oxide synthase, and, to a lesser extent, by an increase in the chemical oxidation of homocysteine and other aminothiols in the circulation. The resultant increase in superoxide levels is further amplified by homocysteinedependent alterations in the function of cellular antioxidant enzymes such as cellular glutathione peroxidase or extracellular superoxide dismutase. One direct clinical consequence of elevated vascular superoxide levels is the inactivation of the vasorelaxant messenger nitric oxide, leading to endothelial dysfunction. Scavenging of superoxide anion by either superoxide dismutase or 4,5-dihydroxybenzene 1,3-disulfonate (Tiron) reverses endothelial dysfunction in hyperhomocysteinemic animal models and in isolated aortic rings incubated with homocysteine. Similarly, homocysteineinduced endothelial dysfunction is also reversed by increasing the concentration of the endogenous antioxidant glutathione or overexpressing cellular glutathione peroxidase in animal models of mild hyperhomocysteinemia. Taken together, these findings strongly suggest that the adverse vascular effects of homocysteine are at least partly mediated by oxidative inactivation of nitric oxide.