Podcasts about Causative

みなさんこんにちは、かなこです！今日のシャドーイングは「使役受動態（しえきじゅどうたい）」です。今回のPodcastは、オードリーさんの提供でお送りします。 Hi everyone, it's Kanako. Today's shadowing is “Causative-passive Sentences”. “Causative-passive Sentence” is used when you want to say that you were forced or harassed to do, something that you didn't want to. For instance, if you were forced to sing at a drinking party by your boss you can say something like this.「飲み会で上司に歌わされました。」   Before we get started, I want to thank Audrey for supporting my show. ありがとうございます!   それでは はじめていきましょう！ Let's get started！ ***************************************************** ▼Subscribe to my YouTube channel ⁠⁠⁠⁠https://bit.ly/KANAKOYOUTUBE⁠⁠⁠⁠ ▼Buy me a coffee  ⁠⁠⁠⁠⁠https://bit.ly/KANAKO-Coffee⁠⁠⁠⁠ ▼Get your Genki 2 textbook ⁠⁠⁠⁠⁠https://amzn.to/3VIRHKP⁠ ***************************************************** When I was a kid, I was forced to study every day by my parents. 子供の時、両親に毎日勉強させられました。 When I was a kid, I was forced to learn to play the piano by my parents. 子供の時、両親にピアノを習わされました。 I was forced to work overtime by my boss. 上司に残業させられました。 I was forced to drink alcohol by my boss. 上司にお酒を飲まされました。 I was forced to come to the office on Sunday by my boss. 上司に日曜日に会社に来させられました。 I was forced to carry my girlfriend's bag. 彼女に荷物を持たされました。 I was forced to go shopping with my girlfriend. 彼女に買い物に付き合わされました。 I was forced to wait at the station by my boyfriend. 彼氏に駅で待たされました。 I was forced to make breakfast by my boyfriend. 彼氏に朝ご飯を作らされました。 I was forced to listen to my friend complaining. 友達に愚痴を聞かされました。 I was forced by my friend to help her with her homework. 友達に宿題を手伝わされました。 I was forced to dance at the party by my friend. 友達にパーティーで踊らされました。 ***************************************************** では もう 一度、最初から 全部 いってみましょう。 Let's try shadowing the whole thing again from the beginning.

Sparks fly in Megan Staffel's novel, The Causative Factor (Regal House 2024), when Rachel is randomly paired with Rubiat, a fellow student, for an assignment in their college art class. After a heavenly night together, they go hiking, and he dives off a cliff, disappearing without a trace. Although Rachel graduates with an art degree, moves to New York, and supports her painting as an ESL teacher, she's scarred for years by the mystery of Rubiat's disappearance. This is a sweet coming-of-age, but also a suspense-filled novel told in shifting viewpoints, about art, growing up, making choices, and finding love. Megan Staffel splits her time between a farm in western New York State and an apartment in Brooklyn. She is an avid walker, bird watcher, and gardener. Her new novel, The Causative Factor, was inspired by a hike she took with her husband in a state park in October, 2020 and grew into a story about an artist trying to understand the mysterious disappearance of her lover. Staffel's interest in the arts and in the process of art-making has been a life-long passion. Her first novel, She Wanted Something Else, was a story about an artist as well. Staffel's other book publications include a third novel and three collections of short stories. She taught for many years in the MFA program at Warren Wilson College and writes a monthly Substack newsletter, "Page and Story." Learn more about your ad choices. Visit megaphone.fm/adchoices Support our show by becoming a premium member! https://newbooksnetwork.supportingcast.fm/new-books-network

Sparks fly in Megan Staffel's novel, The Causative Factor (Regal House 2024), when Rachel is randomly paired with Rubiat, a fellow student, for an assignment in their college art class. After a heavenly night together, they go hiking, and he dives off a cliff, disappearing without a trace. Although Rachel graduates with an art degree, moves to New York, and supports her painting as an ESL teacher, she's scarred for years by the mystery of Rubiat's disappearance. This is a sweet coming-of-age, but also a suspense-filled novel told in shifting viewpoints, about art, growing up, making choices, and finding love. Megan Staffel splits her time between a farm in western New York State and an apartment in Brooklyn. She is an avid walker, bird watcher, and gardener. Her new novel, The Causative Factor, was inspired by a hike she took with her husband in a state park in October, 2020 and grew into a story about an artist trying to understand the mysterious disappearance of her lover. Staffel's interest in the arts and in the process of art-making has been a life-long passion. Her first novel, She Wanted Something Else, was a story about an artist as well. Staffel's other book publications include a third novel and three collections of short stories. She taught for many years in the MFA program at Warren Wilson College and writes a monthly Substack newsletter, "Page and Story." Learn more about your ad choices. Visit megaphone.fm/adchoices Support our show by becoming a premium member! https://newbooksnetwork.supportingcast.fm/literature

In this talk, Rev Lee discusses that Causative Power is the idea that our thoughts, beliefs, and consciousness act as the cause, and the conditions in our lives are the effect. If you found this content valuable, please support our mission by donating: https://app.easytithe.com/app/giving/agapespiritualcenter

みなさんこんにちは、かなこです！今日のシャドーイングは「使役形（しえきけい）」です。 Hi everyone, it's Kanako. Today's shadowing is “Causative Sentences” You can describe who makes someone do something, and who lets someone do something. Causative sentences can be used in relationships such as parents and kids, teachers and students, and bosses and staff. For example, if I made my juniors pick up the balls, it would be like this「後輩にボール拾いをさせました。」   それでは はじめていきましょう！ Let's get started！ ***************************************************** ▼Subscribe to my YouTube channel ⁠⁠⁠⁠https://bit.ly/KANAKOYOUTUBE⁠⁠⁠⁠ ▼Buy me a coffee  ⁠⁠⁠⁠⁠https://bit.ly/KANAKO-Coffee⁠⁠⁠⁠ ▼Get your Genki 2 textbook ⁠⁠⁠⁠⁠https://amzn.to/3VIRHKP⁠ ***************************************************** I made my kids study. 子供に勉強させました。 I made my kids eat vegetables. 子供に野菜を食べさせました。 I made my kids do their homework. 子供に宿題をさせました。 I made my kids clean the toilet. 子供にトイレ掃除をさせました。 I made my staff prepare the documents. 部下に書類を作らせました。 I made my staff work overtime. 部下に残業させました。 I made my staff to go buy lunch. 部下にお弁当を買いに行かせました。 I made my staff prepare the conference room. 部下に会議室の準備をさせました。 I made my staff make tea. 部下にお茶をいれさせました。 I made my junior carry the luggage. 後輩に荷物を運ばせました。 I made my junior pick me up at the station. 後輩に駅まで迎えに来させました。 I made my junior help me with my homework. 後輩に宿題を手伝わせました。   ***************************************************** では もういちど、さいしょから ぜんぶ いってみましょう。 Let's try shadowing the whole thing again from the beginning.

reference: Sri Aurobindo and the Mother, The Hidden Forces of Life, Ch. 5 Occult Forces, pp 102-103 This episode is also available as a blog post at https://sriaurobindostudies.wordpress.com/2024/05/30/matter-subtle-matter-the-causative-level-and-the-ability-of-mind-power-or-vital-power-to-create-modify-influence-and-dissolve-material-forms/ Video presentations, interviews and podcast episodes are all available on the YouTube Channel https://www.youtube.com/@santoshkrinsky871 More information about Sri Aurobindo can be found at www.aurobindo.net  The US editions and links to e-book editions of Sri Aurobindo's writings can be found at Lotus Press www.lotuspress.com 

reference: Sri Aurobindo and the Mother, The Hidden Forces of Life, Ch. 4 Cosmic and Universal Forces, pg. 82 This episode is also available as a blog post at https://sriaurobindostudies.wordpress.com/2024/05/09/the-material-universe-the-causative-plane-and-the-forces-of-manifestation/

Do you know when and how to use causative verbs like make, have and get?

UKMFA are very pleased to support The Clinic of Natural Medicine. In this broadcast we chat with Janet Wrathall ND about her journey into natural medicine and the plans for the clinic.Janet is a registered Naturopath, Herbalist, Causative homeopath, Holistic Iridologist, Nutrition & Dietary Advisor, Homotoxicologist and Certified NES BioEnergetic consultant.We look at the drawings for this wonderful new clinic and discuss the services provided. As demand for alternative approaches in patient centred, ethical medicine grows, such clinics will be key to maintaining a healthy life.Visit Janet's website at: www.clinicofnaturalmedicine.ukEmail her at: info@clinicofnaturalmedicine.ukCALL TO ACTION: Please follow us and subscribe on our YouTube and Rumble channels and please share our content on social media and with friends and family, to help us get the message out and increase our reach.All our podcasts can also be found on the major audio platforms e.g. Apple and SpotifyPlease visit the UK Medical Freedom Alliance at www.ukmedfreedom.org to access all our material and resources. We are grateful for all donations (one off or regular donations through Buy Me a Coffee or Stripe on our website) to help us to continue and grow our work; lobbying decision makers; educating and empowering the public; running campaigns and producing our podcasts.

Have you ever seen the movie, Good Morning Vietnam with Robin Williams? In that movie, an army base had William's character work as a radio dj, and his personality had everyone on the base laughing. Except of course his supervisors, who wanted to have him transferred. Have someone do something, have someone doing something, and have someone done. By the end of this podcast, you'll have learned six different ways to use have in the causative. Join my Podcast Learner's Study Group here: https://learn.myhappyenglish.com/transcriptVisit my website: https://www.myhappyenglish.com/

Watch the video version of this audio ⁠here⁠. Visit ⁠FreeHebrew.online⁠

reference: Sri Aurobindo and the Mother, Our Many Selves: Practical Yogic Psychology, Chapter 2, Planes and Parts of the Being, pp. 65-67 This episode is also available as a blog post at https://sriaurobindostudies.wordpress.com/2023/09/02/the-subtle-planes-are-causative-to-the-external-physical-reality/

Twentieth Sunday in Ordinary TimeFr. Mike Schmitz, in his podcast, "Catechism in a Year," speaks about a therapeutic deistic god in which much of our culture has come to believe the kind of role God plays in our lives. A therapeutic experience makes us feel good like watching our favorite talk show while deism is understood to mean a supreme being who exists but is distant.The reason why a therapeutic deistic god is so appealing is because this kind of philosophy gives human beings the false notion that we can do whatever we want when we want to do it while still feeling the love of god. Gratefully, this is not the God of the Bible nor is it the God of our lived experience. When we look at our Gospel for today, we read about a beautiful miracle story in which a persistent women approaches Jesus while asking Him to heal her daughter who is possessed by a demon. Jesus clearly becomes a causative agent in the healing of this young girl. We see time and time again throughout human history, an all-powerful, all-knowing, all-loving God who freely enters into humanity and into our daily lives. Having encountered the Lord, where would be a good place to invite Him into your life? Scripture Readings for August 20, 2023Isaiah 56:1, 6-7Psalm 67:2-3, 5, 6, 8Romans 11:13-15, 29-32Matthew 15:21-28   

“Realizing that you are more causative in life than effective life, that'll be the biggest change in your life.” —Jeremy SlateBeing a bystander in life might be easy, but it never leads to true fulfillment. It's true that it takes courage to become the causative force in our own story. But, to truly achieve success and happiness, we must take an active role in shaping our own reality. This week's episode is focused on how we can do just that while also opening more opportunities for ourselves. Listen in as Ann and Jeremy Slate, the Host of Create Your Own Life Podcast share how we can turn adversity into our strength and how our inner dialogue affects our present. They also discuss the difference between following our passion vs finding it, the value of apprenticeship, how helping others can be therapeutic yet why we must be careful when offering one, why choose who we associate with, and how we can operate from a place of abundance. Connect with Ann on Social Media:  Website: https://seednutrition.com/Annt/home Facebook: https://www.facebook.com/profile.php?id=100008572834952 Instagram: https://www.instagram.com/annthemasterhealer/ Episode Highlights: 02:30 Finding Your Passion vs Following Your Passion06:52 A Big Gap In The Education System12:49 Why People Don't See Change19:03 Be Careful When Giving Help 23:51 How to Channel Adversity as a Strength29:21 It's a Mental Matter 32:07 Know Who You Associate With36:16 Lack vs Abundance 41:29 You Are More Causive Than Effective

Go here to check out the Shorts collection at lululemon. Check out the Shorts collection and try new things this spring! The Hotty Hot shorts, the Wunder Train shorts, and the Pace Breaker shorts stretch and move with your body so that you feel confident and connected! Go here to check out the Shorts collection at lululemon! Learn more about your ad choices. Visit podcastchoices.com/adchoices

2.21 Pneumonia: Lobar, Broncho, and Interstitial Pulmonary system review for the USMLE Step 1 Exam Pneumonia is an infection of the lung parenchyma that deals with gas exchange Three classic patterns of pneumonia: lobar, bronchopneumonia, and interstitial pneumonia Lobar pneumonia involves a single lobe of the lung and has four stages: congestion, red hepatization, gray hepatization, and resolution Most commonly associated with strep pneumoniae, also caused by Legionella and Klebsiella Bronchopneumonia is an infection of the bronchi that leads to diffuse infection of adjacent alveoli Causative organisms include strep pneumoniae, klebsiella, H influenza, and staph aureus Interstitial pneumonia is an ongoing infection in the interstitial areas of alveolar walls Causative organisms tend to be different compared to other types of pneumonia and include Mycoplasma pneumoniae, Legionella, chlamydophilia bugs, Coxiella burnetti, and some viruses (influenza and RSV) On chest X-ray, lobar pneumonia shows haziness in a single lobe with sharp demarcation, while bronchopneumonia and interstitial pneumonia show more diffuse haziness throughout the lungs Interstitial pneumonia tends to be more indolent, and patients may have not so good looking lungs on chest X-ray but are up and walking around (walking pneumonia).

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Link to bioRxiv paper: http://biorxiv.org/cgi/content/short/2022.12.20.520730v1?rss=1 Authors: Austin, T. T., Thomas, C., Clifton, L., Blockley, A., Warren, B. Abstract: Aging is due to a complex decline of multiple biological processes. Some of the causes include oxidative damage, mitochondrial and proteostatic dysfunction and DNA damage. This results in deterioration as biological systems age. This age-related decline is well quantified, and experienced, for human hearing and is presumed to be due to a decrease in the ears metabolism; specifically a decrease in ability to maintain an electrochemical gradient, the endocochlear potential. However, direct measurements of metabolism across a lifespan in an auditory system are lacking. Even if metabolism does decrease with age is it a cause of age-related auditory decline or simply correlative? All auditory systems across the animal kingdom share functional principles including ion pumping cells, auditory receptors, spiking auditory nerves and multiple supporting cells. Therefore, we used an insect, the desert locust, Schistocerca gregaria, as a physiologically versatile model to understand how cellular metabolism correlates with age and impacts on age-related auditory decline. We found that although metabolism correlates with age-related auditory decline it is not causative. Copy rights belong to original authors. Visit the link for more info Podcast created by Paper Player, LLC

Link to bioRxiv paper: http://biorxiv.org/cgi/content/short/2022.12.08.519616v1?rss=1 Authors: Zhang, Y., Gregorich, Z. R., Wang, Y., Braz, C. U., Zhang, J., Liu, Y., Liu, P., Aori, N., Hacker, T. A., Granzier, H., Guo, W. Abstract: Human patients carrying genetic mutations in RNA binding motif 20 (RBM20) develop a clinically aggressive dilated cardiomyopathy (DCM). RBM20 is a splicing factor with two canonical domains, an RNA recognition motif (RRM) and an arginine-serine rich (RS) domain. RRM loss-of-function disrupts the splicing of RBM20 target transcripts and leads to systolic dysfunction without overt DCM, while mutations in the RS domain precipitate DCM. We show that mice lacking the RS domain (Rbm20deltaRS) manifest DCM with mis-splicing of RBM20 target transcripts. We found that RBM20 is mis-localized in Rbm20{Delta}RS mice but not in mice lacking the RRM, which are also deficient in RBM20 splicing. We determine that the RS domain, not other domains including the RRM, is critical for RBM20 nuclear import and define the core nuclear localization signal (NLS) within this domain. Mutation analysis of phosphorylation sites within the RS domain indicate that phosphorylation is dispensable for RBM20 nuclear import. Collectively, our findings establish disruption of the NLS in RBM20 as a causative mechanism in DCM through nucleocytoplasmic transport. Copy rights belong to original authors. Visit the link for more info Podcast created by Paper Player, LLC

Cancer is not a single disease, but many different diseases that share some common features, most notably uncontrolled cell growth; this is characterised by the loss of normal cellular mechanisms responsible for the control of proliferation, cell differentiation, programmed cell death (apoptosis), cellular organisation, and adhesion. Causative factors can include genetics (e.g. BRCA, FPC), lifestyle (e.g. obesity, alcohol, drugs), environmental (e.g. toxic exposures, air quality), physical (e.g. radiation, heat, trauma/inflammation), immune (e.g. HIV immunosuppression), endocrine (e.g. estrogen and endometrial cancer), and viruses (e.g. HPV). Exercise reduces the risk of a variety of cancers, and may also improve survival rates of certain cancers. In this episode, we discuss the details of how exercise prevents cancer, and also how it can improve quality of life and prognosis for those with existing cancer. Join the Email List https://forms.aweber.com/form/77/857616677.htm Interested in coaching with Triage? Email info@TriageMethod.com and the Triage Team will get back to you! Or you can read more and fill in a contact form at https://triagemethod.com/online-coaching/ Interested in getting certified as a Nutrition Coach? Check out our course here: https://triagemethod.com/nutrition-certificate/ Have you followed us on social media? Youtube: https://www.youtube.com/channel/UCzYO5nzz50kOAxo6BOvJ_sQ Instagram: https://www.instagram.com/triagemethod/ Facebook: https://www.facebook.com/triagemethod/

Guest: Lirandzu Themba, Police Ministry Spokesperson.See omnystudio.com/listener for privacy information.

Causative is an adjective that means acting as a cause. The Latin word cau SARE ay) cow SARE ay) means ‘to cause.' This gave us the English word cause. Our word of the day adds the suffix A-T-I-V-E to indicate a characteristic of the word. I didn't feel the aspirin I took was causative of my stomach ache. My taking it and the stomach ache took place on the same day, but one did not cause the other.

Judy Becker Worsley and David Berkshire return for another episode and a deeper dive into the Worsley Five Element lineage. Judy continues to share with us the impact on her life of the philosophies of the Five Elements system and how it has always served as a compass for her. The teachings of JR Worsley, that she and David continue to passionately share, help to liberate practitioners from the brainwashing of society, including the fallacy that by labelling people, we better understand them. Foundational to JR's teaching are the practices of humility, curiosity, and presence. These not only are hallmarks of impactful practitioners of medicine but also of practitioners of life as they help the individual transform into state of freedom and peace. We also explore more technical details of Five Element medicine, especially through an examination of the differences between constitutional factors and causative factors. And we conclude with the power of Five Elements in helping us to better understand the natural order of all. Judy Becker Worsley has been a devoted student of Professor JR Worsley since 1973, and was designated by JR to succeed him as Master of the lineage upon his death. Prior to his death, they founded the Worsley Institute, which is dedicated to the preservation and promotion of the Worsley Five Element Acupuncture tradition that is rooted in natural law. Joining Judy in this episode is David Berkshire, President of the Worsley Institute, located in Portland, Oregon, where David also has a busy clinical practice. Please enjoy this episode of Pacific Rim College Radio with Judy Becker Worsley and David Berkshire. Episode Links: Worsley Institute Learning Links: School of Acupuncture and Chinese Medicine at PRC Online Acupuncture and Chinese Medicine courses at PRCOnline Student Clinic at PRC

Welcome to another episode of Coffee Break German! In Lesson 19 Mark and Andrea discuss adverbs which connect clauses: daher, deswegen, deshalb, darum, also, folglich, demzufolge and somit. We then listen to three separate voicemails in which we hear causative adverbs in context. Listen out for these useful words and phrases: etwas hinterlassen, die Rückrufnummer, unterwegs sein.If you'd like to take advantage of bonus materials, lesson notes and a translation challenge, you can access the full Coffee Break German Season 3 course on the Coffee Break Academy. See acast.com/privacy for privacy and opt-out information.

The concept of motivating people is a misnomer really.  It is a short form of saying, as the leader, we build the right relationship, the right culture and create the right environment where our people can motivate themselves to be successful.  Yelling at someone to “be motivated, be motivated, be motivated” sounds and is ridiculous.  We know that but do we have a good alternative?  The degree to which we know our people is the key.  Well we think we know them, but often it is only at a very superficial level.  Bosses are busy very people, time is short and there is a lot to do.  Getting to know our people in depth is a big task, one which takes considerable time and requires a sustained effort.  This is why most leaders don't bother.   When we take over the boss role we probably went around to everyone in the team and interviewed them about what they do, how they do it, how they like it and any issues they have which, we as the new face, may be able to solve for them.  This is probably the only time we interview them.  We catch up at performance review time, going over the Key Performance Indicators, but we don't really dig into the entrails about how they are going and what they think about the firm.  Then we move on to our next role and we repeat the same process.  The end result is we work with people, but we never really know them to any great or meaningful extent.  It doesn't have to be like this and we can get to know people in a way which will allow us to appeal to their nobler and highest motivations.   We use a methodology called not the “interview” but the “innerview”.  This is not a single encounter in the first thirty days of taking on the leader role for the team.  It is a piecemeal, gradual accumulation of understanding of our people.  It may be over coffee, a lunch, a casual conversation.  The word casual here is key.  Yes, there is intention.  We want to get to know our people so that we can provide what it is they want from the firm and the work, positioning ourselves as the leader who can deliver those things.  At the same time it cannot be an interrogation. It cannot be manipulative.  This is a fine line however. We need to get to know how they tick, in order to help them, without it becoming a cunning plan to use them for our own glorious, ever upward, brass ring grabbling, dastardly plot to climb to the top of the corporate ladder.   There are levels of depth in getting to know someone.  Factual questions are the simplest.  Where did you grow up, go to school, go to university, what did you study, what sports did you play, what are your hobbies, where have you travelled, who is in your family unit, where do you live, where else have you worked, etc.  Obviously we are not going to ask these like a barrage of rapid fire quiz show questions.  These types of context, background questions will get answered over time, through the natural flow of causal conversation.  We shouldn't be forcing it, like we are holding a clipboard survey with boxes to be checked, as we unearth each answer.  In these answers there are connectors with our own story.  We may have lived in the same city or studied a similar subject or even have gone to the same university.   Causative questions are the next layer down.  These are the deeper “why” and “what” questions, as we uncover the motivations and aspirations of the individual.  Why do they like this hobby? Why did they choose this city to live in or this university or this field of study or work?  Why did they move from one company to another.  The latter questions we may have asked during the hiring process, but that was a while ago and we may not recall the detail or they may have been somewhat guarded in their answers at that point in joining the firm or maybe they were already in the team and we are the new arrival.   The deepest level of questioning is around the value-based questions. Knowing the values of the person helps us a lot as the leader, because we can see if there is alignment or not with our own values and with the values of the firm.  These are rather sensitive, personal questions, so there has to be a certain level of trust already established through the earlier questions before we can get to this stage.  Busting right in with such a deep values based question might alarm the team member and they may feel some manipulation is going on.   After listening to them tell us about their career so far, we might ask, “looking back on your career so far is there anything you would do differently?”, “Many people have benefitted from mentors in their work, has that been the case for you”, “ What has been something in your work you look back on with great pride”, “ Life doesn't go in a straight line so do you have any advice for people who may be going through a tough patch at the moment”.   This whole process has to have the correct kokorogamae, or true intention, about why we are doing it.  If we are working out how best we can use people, then we will only damage the relationships, because people are not stupid.  If on the other hand, we are seeking to establish common ground, common needs and common values to deepen our understanding and therefore work out how we can help them to move upward in their career path, then we are on the right track.  Time, place and occasion are three considerations for holding these types of conversations.  We shouldn't feel we are on a schedule and be in a rush to get to know our people better through these innerview questions.  Authentic, casual, non-probing conversation is the key to learning how best to create the ideal work environment which will help our people to succeed.

Here's the last TOEFL iTP Listening Part A module! It's been 4 months of uploading sneak peeks and now it's time to finish ONLY PART A! Dialogs will resume next week (post-test and available for course buyers only) followed my the TOEFL iTP Listening Parts B and C. It's been a hell of a long journey and it's time to sum this up!TOEFL iBT Writing Course: https://arsenioseslpodcast.podia.com/toefl-ibt-pre-writing-coursePodia TOEFL iTP Course (Reading): https://arsenioseslpodcast.podia.com/toefl-itp-reading/buyPodia TOEFL iTP Course (Structure): https://arsenioseslpodcast.podia.com/toefl-itp-structure/buyPodia TOEFL iTP Course (Written Expression): https://arsenioseslpodcast.podia.com/toefl-itp-written-expressionPodia TOEFL iTP Course (Listening): https://arsenioseslpodcast.podia.com/toefl-itp-listeningInstagram ESL Podcast: https://www.instagram.com/arsenioseslpodcast/Podcast on Spotify: https://open.spotify.com/show/7hdzplWx6xB8mhwDJYiP6fFacebook: https://www.facebook.com/Arseniobuck/?ref=bookmarksYoutube: https://www.youtube.com/channel/UCIzp4EdbJVMhhSnq_0u4ntABuzz sprout: https://www.buzzsprout.com/165390

Please join authors Babken Asatryan and Anwar Chahal, and Associate Editor Ntobeko Ntusi as they discuss the Primer article "Inflammation and Immune Response in Arrhythmogenic Cardiomyopathy: State-of-the-Art Review." Dr. Carolyn Lam: Welcome to Circulation on the Run, your weekly podcast summary and backstage pass to the journal and its editors. We're your co-hosts, I'm Dr. Carolyn Lam, associate editor from the National Heart Center and Duke National University of Singapore. Dr. Greg Hundley: And I'm Dr. Greg Hundley, associate editor, director of the Pauley Heart Center at VCU Health at Richmond, Virginia. Well, Carolyn this week, our feature discussion, we're not going to go with one of our original articles, but we are going to feature a primer and a primer is a state of the art review article. The topic is going to be on arrhythmogenic cardiomyopathy and we'll be looking at the role of inflammation and the immune response in arrhythmogenic cardiomyopathy. But before we get to that feature, how about we grab a cup of coffee and talk about some of the other articles in the issue? Would you like to go first? Dr. Carolyn Lam: I would, because guess what? I'm going to be talking about prescription opioids. We know these are a major contributor to the ongoing epidemic of persistent opioid use. What do you think is the incidence after cardiac implantable electronic device procedures? Greg, let's start with a Greg Hundley quiz. I'll give you multiple choice, how about that? Do you think it is 1%, 10%, 25%. 50%? Dr. Greg Hundley: All right, Carolyn, I'm going to guess here. I'm going to go 10%. Dr. Carolyn Lam: Smart. Well, guess what? Today's paper actually gives us insight into that question, it's from Dr. Frankel from the hospital of the university of Pennsylvania and his colleagues, and these authors performed a retrospective cohort study using data from a national Administrative Claims Database from 2004 to 2018 of patients undergoing cardiac implantable electronic device procedures. Adult patients were included if they were opioid naive during the 180 day period before the procedure and did not undergo another procedure with anesthesia in the following 180 days. Dr. Carolyn Lam: Persistent opioid use, which is what we're interested in, was defined by filling an additional opioid prescription more than 30 days following the procedure. So, here's your answer. Of the more than 143,000 patients meeting these inclusion criteria, 11%, so you were right Greg, 11% filled an opioid prescription within 14 days of surgery. Among these patients, persistent opioid use occurred in 12.4% of patients, 30 to 180 days after surgery. The likelihood for developing persistent opioid use was increased for patients who had a history of drug abuse, pre-operative muscle relaxant or benzodiazepine use or opioid use in the prior five years. Also, patients who have prescribed more than 135 milligrams of oral morphine equivalence had a significantly increased risk of persistent opioid use. Dr. Carolyn Lam: Now, this is important because all physicians who perform cardiac implantable electronic device procedures and care for these patients should be aware of the risk of persistent opioid use. This is discussing in editorial by Dr. Kandil from UT Southwestern. Dr. Greg Hundley: Very interesting Carolyn, so connecting sometimes the prescription use of opioids after cardiac implantable electronic devices. Great presentation. Well, my first paper comes to us from the world of preclinical science and it's from our prior editor in chief Dr. Joseph Loscalzo from Brigham and Women's Hospital and the Harvard Medical School. So Carolyn, interferon gamma, producing CD4 positive and CD8 positive T-lymphocytes, have been identified as the predominant pathological cell subsets in human atherosclerotic plaques. Dr. Greg Hundley: While the immunological consequences of these cells have been extensively evaluated, their interferon gamma mediated metabolic effects on endothelial cells remains unknown. So Carolyn, the purpose of this study was to determine the metabolic consequences of the T-lymphocyte cytokine interferon gamma on human coronary artery endothelial cells. Dr. Carolyn Lam: Interesting. So what did Dr. Loscalzo and colleagues find? Dr. Greg Hundley: Right, Carolyn. So, the authors found that interferon gamma impairs endothelial glucose metabolism via altered tryptophan metabolism while depleting NAD plus, which results in a metabolic shift toward increased fatty acid oxidation, and therefore, Carolyn, this work suggests a novel mechanistic basis for pathologic T-lymphocyte endothelial interactions in atherosclerosis, mediated by interferon gamma, linking endothelial glucose, tryptophan, and fatty acid metabolism with NADH and ATP generation and their adverse endothelial functional consequences. Dr. Carolyn Lam: Oh, very nice, Greg. Thank you. The next paper describes a comprehensive characterization of cardiomyopathy caused by filament C truncating variance. Dr. Greg Hundley: Whoa. Okay, Carolyn. Now what is filamin-C? Dr. Carolyn Lam: I thought you may ask and I wasn't going to quiz you, see Greg? The filamin-C gene can cause a striated muscle protein that crosslinks actin and anchors cell membrane proteins to the cytoskeleton, sarcolemmal and sarcomere Z-disc. So, the co-corresponding authors of today's paper Drs. Mestroni and Taylor from University of Colorado, Denver Anschutz Medical Campus, analyzed longitudinal clinical data from an international multicenter cohort of 85 carriers of this filamin-C truncating variants. And this is what they found. Dr. Carolyn Lam: First, the cardiomyopathy associated with filimin-C truncating variants appeared to be a disease with heterogeneous phenotypic presentation, ranging from typical dilated cardiomyopathy to arrhythmogenic, right ventricular cardiomyopathy, and with frequently overlapping forms. Dr. Carolyn Lam: Number two, left ventricular ejection fraction was associated with the risk of death, either all cause or non-arrhythmic, heart transplantation, or LVAD, but not with the risk of sudden cardiac death or major ventricular arrhythmias, highlighting the need for alternative strategies of stratification of the arrhythmic risk in these patients with the filimin-C truncating variant cardiomyopathy. Dr. Carolyn Lam: And number three, this cardiomyopathy was associated with a high risk of ventricular arrhythmias with frequencies of life-threatening ventricular arrhythmias, not significantly different from things like Lamin and desmoplakin cardiomyopathy. Dr. Greg Hundley: Well, Carolyn, just fantastic. My next paper comes to us from Professor Lena Claesson-Welsh from Uppsala University and Carolyn, palmdelphin belongs to the family of paralemmin proteins implicated in cytoskeletal regulation and single nuclide polymorphisms in the palmdelphin locus that result in reduced expression are strong risk factors for development of calcific aortic valve stenosis, and predict the severity of the disease. Dr. Carolyn Lam: Wow, interesting. Palmdelphin, great. So tell us, what did they find and what are the clinical implications please? Dr. Greg Hundley: Right, Carolyn, great question. So first, calcific aortic valves stenosis patients with the single nucleotide polymorphism RS754 3130 express reduce palmdelphin levels in valve endothelial cells, which shows hallmarks of palmdelphin deficiency, such as loss of cytoplasmic RanGAP1, altered nuclear morphology and nuclear rest of P53 of P21. Carolyn, second, gene-regulatory changes affecting actin reorganization, are detected in seemingly healthy regions of calcifying bowels, in agreement with disturbed actin-dependent processes, being an early event, instigating the calcific process. And so Carolyn, the take home message is that palmdelphin is prominently expressed in endothelial cells and the presence of the palmdelphin single nucleotide polymorphism correlated both with a Barrett endothelium and calcific aortic valve stenosis suggesting that endothelial cell dysfunction is essential in development of calcific aortic valve disease. Dr. Carolyn Lam: Oh, wow, wow. Thank you for translating that into the clinical implication. Thanks Greg. Let's maybe discuss what else is in today's issue. There's a prospective piece by Dr. Kirchof entitled “In Patients With Recently Diagnosed Atrial Fibrillation, Think Anticoagulation And Rhythm Control.” There's an exchange of letters between Drs. Liao and Hakala regarding the article Cardiovascular Risk Factor Trajectory Since Childhood And Cognitive Performance In Midlife, The Cardiovascular Risk In Young Finns, study. Dr. Greg Hundley: And Carolyn, I've got a research letter from Professor Ramin entitled “Association Between Sarcomeric Variants In Hypertrophic Cardiomyopathy In Myocardial Oxygenation, Insights From A Novel Oxygen-Sensitive CMR Approach.” Well, how about now we get onto that primer feature discussion relating to arrhythmogenic cardiomyopathy? Dr. Carolyn Lam: Yay. All right, let's go, Greg. Dr. Greg Hundley: Well, listeners, we are now onto our feature discussion and this week we've got a different aspect to the feature discussions. We're going to work through a review article and what we call as a primer. It's one of our state-of-the-art family of publications, where we take a topic and perform a review on a new evolutionary concept that might be occurring in a particular field. This week, we are going to discuss arrhythmogenic cardiomyopathy and we have with us two of the authors of this primer, Dr. Babken Asatryan from Bern, Switzerland and also Dr. Anwar Chahal from Lancaster, Pennsylvania. And of course, as always, we invite one of our associate editors and we have with us this week Ntobeko Ntusi from South Africa. Welcome gentlemen and Babken, let's start with you. Can you give us just a little bit of review regarding arrhythmogenic cardiomyopathy? We hear that term as opposed to arrhythmogenic right ventricular cardiomyopathy, and then maybe also, what are the underlying fundamental histopathologic and pathophysiologic findings associated with this disease? Dr. Babken Asatryan: Thank you, Greg. It's really an absolute pressure being here and thank you for your invitation again. So arrhythmogenic cardiomyopathic is genetically-determined heart disease and the common cause of sudden cardiac death in individuals younger than 40 years of age, it's characterized pathologically by fibrosis and/or fibro fatty infiltration of the myocardium. This infiltration provides a substrate for electrical and stability and leads to ventricular arrhythmias ranging from isolated premature ventricular contractions to sustain ventricular tachycardia and ventricular fibrillation. Live ventricular arrhythmias are cardio manifestations of the orthogenic cardiomyopathy, and they typically occur at early stages of the disease, preceding pathological and functional abnormalities. We call that a concealed stage of the disease. Dr. Babken Asatryan: The typical form for arrhythmogenic cardiomyopathy, which has been previously termed as arrhythmogenic right ventricular cardiomyopathy, primarily affects the right ventricle and has been recognized for decades. Following implementation of postmortem autopsy, increased use of contrast, enhanced cardiac MRI, and improved understanding of the genotype phenotype correlations, more recently cases with more pronounced left ventricular involvement have been discovered as well as cases with biventricular involvement of the disease. Dr. Babken Asatryan: Nowadays, we believe that around 60% of cases have also left ventricular involvement, even if they're diagnosed based on the 2010 task force criteria for arrhythmogenic cardiomyopathy. Causative variants in desmosomal genes are identified in about 60% of patients with typical arrhythmogenic right ventricular cardiomyopathy. Dr. Babken Asatryan: Recently, there have been studies reporting non-desmosomal gene variants in patients with arrhythmogenic right ventricular cardiomyopathy, as well as in those left ventricular and biventricular forms of the disease. But the left ventricular form is quite new to us, so we are learning a lot every day about this disease. Dr. Babken Asatryan: The pathogenesis of this condition appears to be quite complex. We know that these pathogenic variant in desmosomal genes can initiate several pathways and these could be gene dependent. What we do know, that these eventually lead to fibrosis and fibro fatty infiltration of the myocardium, which is the hallmark feature of arrhythmogenic cardiomyopathy. Dr. Greg Hundley: And patients present generally when, in terms of lifespan? Dr. Babken Asatryan: So, patients present in between 30 to 40 years of age, there's a typical presentation for arrhythmogenic cardiomyopathies but young presentations are also common nowadays, particularly. So, programs in families, they usually present 30 to 40 years of age. But in families, we do discover patients who have typical arrhythmogenic right ventricular cardiomyopathy or left and right ventricular involvement were younger at age, but they still need the criteria. Dr. Greg Hundley: And then when we diagnose this condition, do we also need to think about, at least clinically, looking for other affected individuals within a family? Dr. Babken Asatryan: Absolutely. So most of the arrhythmogenic biventricular cardiomyopathy, arrhythmogenic left ventricular cardiomyopathy cases are autosomal dominant diseases. So, this means if an individual carries a pathogenic variant in one of the genes responsible for the condition, the likelihood that the first degree family members will carry the same variant is about 50%. The disease however, presents with reduced penetrance and variable expressivity. Some of the family members may have just arrhythmias and others may develop arrhythmias and structural heart disease. And some of the individuals who carry pathogen occurrence in desmosomal are the genes responsible for the condition may not show phenotype at all. So, that makes the decision-making in families quite challenging. Dr. Greg Hundley: Very nice. Well, thank you so much Babken and now, we're going to turn to one of your co-authors, Anwar and Anwar, in this primer, you start to present a new sort of theme, that inflammation actually may play a role in this disease, at least in terms of adverse events. Can you describe a little bit what your team was thinking here and what took you in this direction and what are some of the research that you've revered here that supports this new line of thinking?   Dr. Anwar Chahal: Thanks, Greg and Ntobeko, for first, the kind invitation to come on this podcast. I must add that I normally listen to the podcast and very much enjoy it, so it's a great honor and privilege for us. Dr. Anwar Chahal: Let me contextualize it, I think it's important to think about what are problems are when we evaluate cases, whether that's the program or the family members, and try to determine what's actually going on. There's been a number of changes over the last 15 years that really evolve around a better understanding and the availability of multimodality imaging, which has altered the way we evaluate these cases. If you look at the 2010 taskforce criteria, for example, they talk about volumetric changes and injection fractions by echo or MRI, and even ventriculogram synapse on fluoroscopy, which I don't think many people do anymore, but they don't mention gadolinium enhancement, and there is an updated version that will come out and talk about that, and the advantages of MRI and even contrast-enhanced CT, and now 18F-FDG, CT PET imaging. Dr. Anwar Chahal: So, the patient journey and the problem that we face is that actually some people present with very unusual features, chest pain, troponin rise, undergo coronary angiography, normal coronary arteries, or unobstructed coronary arteries. We put them through MRI scanners and we see a little bit of gadolinium enhancement. We follow them over the next five years or so, and it develops into taskforce criteria, positive ARVC. So, that's the sort of clinical angle where we've started to see this. Dr. Anwar Chahal: As we put people through scanners, we see the hearts lights up on PET scanners, pretty reproducibly and reliably, that tells us that there's some inflammation there. We look back into the literature and actually very, very early work that was done, autopsy-based, some of it endomyocardial biopsy-based describing lymphocytic infiltrates. Usually that's dry, as you say, or sterile, but there have been reports of even viral pathogens. Dr. Anwar Chahal: That's where it stirred this debate up for us about whether there's this signal that we're seeing there, what is it? What's actually going on? It raises a question, we recognize the other mechanisms, the fiber fatty replacement, the apoptotic pathways, that contribute to that. But there's such variable expressivity with this disease. It's a difficult disease to pin down and it raises a question. What are these other effect modifiers? Is there something else that we do not recognize? And that's really what's driven this. Dr. Anwar Chahal: Our group of co-authors are leaders in the field. Some of them are colleagues in veterinary medicine, Dr. Anna Geltser, and we work together on boxer dog patients. So, she is a practicing vet and a scientist, and has lots of boxer dogs with arrhythmogenic cardiomyopathy. We've been looking at how we could utilize that as a model to test some of the findings that we have in humans and pioneering work really by Bob Hamilton in Toronto, in this paper where they described anti-DSG2 antibodies, which were found not only in humans, whatever the underlying genotype, but also in boxer dogs with arrhythmogenic cardiomyopathy. And that's been followed up with work from Europe, describing anti-heart antibodies, anti-intercalated disk antibodies. Dr. Anwar Chahal: It doesn't really matter what the genotype is, but we're seeing these antibodies there and we're seeing these positive scans indicating inflammation. So the big question is, is this inflammation of primary insult or is it secondary? Is it that the heart in somebody with a genetic cardiomyopathy is predisposed, maybe the remodeling is affected. Bob Hamilton thinks this is probably the best explanation to explain why, whatever the genotype, that these antibodies were positive, that actually that myocardium becomes exposed. The epitope of DSG is now exposed to the immune system, which mounts an antibody response, and hence you see the rise in these antibodies, but it's possible it could it be primary as well. With COVID, and this is a bit of a stretch, so just bear with me there, with COVID we've been recognizing that there's myocardial injury. Dr. Anwar Chahal: There's not as much myocarditis as we expected, but there's been, with virus SARS-CoV-2, we know regular human coronavirus is a recognized cause of viral myocarditis. So, the question really arose are we going to see a lot more of this myocarditis? In our lab discussion, it was, "Well, do you think we're going to see something similar in that we've seen with arrhythmogenic cardiomyopathy, these genetically predisposed individuals are more likely to get invaded? Now, we haven't really seen that with COVID and I won't delve too much into it, but going back to the classical viral infections that we see with myocarditis, here's a really, really interesting biological link. Most of them invade through the desmosome, so with SARS-CoV-2, we see the ACE2 receptors as the way the virus really invades. But with these regular coxsackie virus, for example, parvovirus, a lot of them invade through the desmosome, and that's where we thought, here's a link. Dr. Greg Hundley: Very nice. Ntobeko, you see a lot of papers come across your desk. What attracted you to this group of investigators and this particular review article? Dr. Ntobeko Ntusi: Thank you very much, Greg. I want to start by congratulating Babken, and Anwar for a really fantastic submission, which as an associate editor, was an absolute pleasure to handle. There really are six things that stood out for me about this article. The first one really relates to the question that you ask Babken, which relates to the nomenclature and people have traditionally thought of this is a disease of the right ventricle. I think it's now timely to consider a clear change in nomenclature, that recognizes not only right ventricular involvement, but also left ventricular involvement. And the common finding of biventricular disease in patients with ACM. Dr. Ntobeko Ntusi: The second really important contribution for me from this primer was that we've always thought of arrhythmogenic cardiomyopathies as a genetic disorder with abnormalities in the genes, encoding components of the desmosome. Many groups recently, including our own group that described novel mutations for arrhythmogenic cardiomyopathy in adhering to poultry and other genes outside of the desmosome are showing that the genetic underpinnings are much wider. But the key contribution here is really the consideration of the centrality of inflammation to the pathogenesis of this disease. Anwar has spoken to some length about that, so I won't rehash those comments, but for me, what is key for future work in this area is really to clarify whether the inflammation, as in with many other forms of cardiovascular disease, is merely an epiphenomenon, or whether it plays a critical role in the causal pathway for the phenotypes that we see. Dr. Ntobeko Ntusi: The next important feature for me was the review of the literature and evidence in the association with myocarditis. So, we've seen lots of case reports and small case series showing young people presenting with myocarditis and meeting either the Dallas criteria histologically, or the Lake Louise criteria on imaging, and then subsequent genetic testing confirming the diagnosis of an arrhythmogenic cardiomyopathy. I thought for the first time with quite a compelling review of the link between these two. Dr. Ntobeko Ntusi: The fourth important contribution relates really to the contribution of imaging modalities, both in diagnostics, but critically in risk stratification for this clinical entity. And for me, the importance of cardiovascular magnetic resonance, either with planimetric mapping or late gadolinium enhancement to really add to our ability to predict future events. Dr. Ntobeko Ntusi: Then there's been quite a number of publications in the last five years that have clarified our understanding of the at risk patient with arrhythmogenic cardiomyopathy who's likely to suffer a sudden cardiac death event. This tends to be somebody who was young, who was male, who has a history of documented non-sustained ventricular tachycardia or a history of syncope and on ECG, quite extensive T wave inversion. So again, this is nicely reviewed, and we think about those as candidates who'll benefit from implantation of an ICD. Dr. Ntobeko Ntusi: Then I thought for me, the last really nice contribution from this piece was the review of advancing our understanding of the hot phase. So in all forms of heart muscle disease, we speak of the presentation of patients with the chest pain syndrome, with a troponin leak, but unobstructed coronaries. On further investigation, we don't really find any other evidence of an inflammatory event. We call this a hot phase. And in some case reports in small case series, endomyocardial biopsy has revealed the association of these, whether in TCM, HCM, or arrhythmogenic cardiomyopathy with lymphocytic infiltration. I thought this was all very nicely reviewed. Dr. Ntobeko Ntusi: So, the question that really left me with having read this review, was whether in the future, we may actually need to consider targeting inflammatory pathways as a therapeutic target in this heart muscle disorder. Thanks Greg. Dr. Greg Hundley: Yes. Thanks so much in Ntobeko. You've really led us to the next question that I'm going to ask both Babken and Anwar, you've discussed where do you feel this field is moving and what is the next study or series of studies we need to perform. Babken, first you, and then Anwar. Babken, what do you think is the next study to be performed in this space? Dr. Babken Asatryan: I so much agree with Ntobeko, that perhaps understanding better what can be targeted in these patients, in order to prevent development of phenotype or least to prevent cardiac events, is perhaps the most important next step. In our first figure, we have summarized this potential mechanisms, involving inflammation leading to with arrhythmogenic cardiomyopathy in these patients. We have also highlighted the potential mechanisms that perhaps in the future can be targeted. This could include both targeting the inflammatory cytokines, as well as the primary agents that cause the myocardial inflammation in patients, depending on the results that we will receive over the next years and perhaps animal models should be the next step to better understand how similar arrhythmogenic cardiomyopathy phenotype, where inflammatory contributors to the phenotype are important. And then we can understand whether this can be the same in humans as well. Dr. Greg Hundley: Very nice. And Anwar, do you have anything to add? Dr. Anwar Chahal: Yes. So, agree with that. I guess I would add what are we doing to try to help decipher this? So some of the work that we're doing, I mentioned earlier with the boxer dog patients, who have arrhythmogenic cardiomyopathy. So some of the aspects that we're actually looking at is taking swab cells to see if we can phenotype as a alternative tender myocardial biopsy. And one of the co-authors, Angeliki Asimaki, really pioneered that as a alternative tool because the desmosis are ubiquitous and this may help us phenotype patients better. But also, we want to look at using that as a tool in the pheno copies of arrhythmogenic cardiomyopathy. So we would advocate, re-phenotyping people as well as possible and trying to use some of these techniques. Dr. Anwar Chahal: The next thing we're really looking at is antibody based tools, either working with collaborators, who've already described these antibodies such as anti-DSG2, anti-heart antibody, and anti-skeletal disc to see if we can develop those and perhaps identify others in both human and ox models. And that will then hopefully open the way for us to develop therapeutics that may be able to target those and address that, and maybe use these antibodies as markers to see disease progression, or halting of disease. Dr. Greg Hundley: Very nice. Well listeners, we want to thank Dr. Babken Asatran from Bern, Switzerland, Anwar Chalal from Lancaster, Pennsylvania, and our own associate editor, Ntobeko Ntusi from South Africa, really helping us see this new scientific consideration regarding the potential role of inflammation in causal pathways of adverse manifestations of arrhythmogenic cardiomyopathy. Well, on behalf of Carolyn and myself, we want to wish you a great week and we will catch you next week on the run. This program is copyright of the American Heart Association, 2021. The opinions expressed by speakers in this podcast are their own and not necessarily those of the editors or of the American Heart Association. For more visit ahajournals.org.

In the previous Study Saturday, we looked at the passive form. This week, we'll look at its counterpart: the causative form. Figure out its meaning — causation or permission — how to conjugate it and use it in daily and work conversations in this episode of Nihongo Master's language series!Start Learning with Nihongo Master!  Website Facebook Instagram Twitter YouTube Music: https://www.purple-planet.com​​About Nihongo Master PodcastA podcast for Japanese culture enthusiasts and language learners. Brought to you by NihongoMaster.com, an e-learning site focused on helping learners at every level master the Japanese language.

In this lesson, I will introduce you the verb form called "causative form". ちち　は　わたし　に　トマト　を　たべさせました。 My father made me eat tomato. はは　は　わたし　に　くすり　　を　のませました。 My mother made me take a medicine. せんせい　は　がくせい　に　きょうかしょ　を　よませました。 The teacher made the students read a text book. おかあさん　は　こども　に　マンガ　を　よませました。 The mother let the child read a comic book. References: Verb Conjugation https://anchor.fm/yuya-sato/episodes/Verb-Conjugation-emv716 Te-forms https://anchor.fm/yuya-sato/episodes/Te-forms-enfaqj Progressive Form https://anchor.fm/yuya-sato/episodes/Progressive-Form-enjvbc Volitional Form https://anchor.fm/yuya-sato/episodes/Volitional-Form-epmave ば-form https://anchor.fm/yuya-sato/episodes/-form-er8f82 Passive Sentence #1 https://anchor.fm/yuya-sato/episodes/Passive-Sentence-1-e10ffo6 Passive Sentence #2 https://anchor.fm/yuya-sato/episodes/Passive-Sentence-2-e10hcve Passive Sentence #3 https://anchor.fm/yuya-sato/episodes/Passive-Sentence-3-e10nv8i

22 --- This episode is sponsored by · Anchor: The easiest way to make a podcast. https://anchor.fm/app Support this podcast: https://anchor.fm/maryamkhkh_/support

The Beyond Clean GoldMind is a free innovative digital dictionary resource for Sterile Processing terms, featuring diverse voices from around the globe who provide definitions to the most common terms in our industry. Releasing 365 days a year, GoldMind is your daily dose of Sterile Processing education and insight to invest in yourself, your future, and the safety of your patient. It is a perfect addition to new technician on-boarding, certification studies, and educational programming in your facility. For more creative Sterile Processing education & resources, visit us at http://www.beyondclean.net #GoldMind #BeyondClean #DigitalDictionary #WordOfTheDay #Education #SterileProcessing #Voices #Network #Listen #Learn #ChangeTheWorld

ALISTER MAGRATH BACKPEDALS; NOW SAYS JUSTIFICATION IS CAUSATIVE, NOT DECLARATIVE AS PROTESTANTS BELIEVE Music by: Life of Riley by Kevin MacLeod Link: https://incompetech.filmmusic.io/song/3976-life-of-rileyLicense: http://creativecommons.org/licenses/by/4.0 --- This episode is sponsored by · Anchor: The easiest way to make a podcast. https://anchor.fm/app

This is episode is very special for me, as Mitch Horowitz is one of my favorite authors on the subject of mind metaphysics, new thought, and the occult. His book The Miracle Club is a must read for anyone interested in the causative power of thought and intention, in which he takes a rational and discerning look at the powers of the mind and how it affects our reality. We talked about this very subject, and also explored Mitch's relationship with Satanism and what that means to him. One of the true luminaries of the Occult world, and a scholar of profound depth, this episode is not to be missed.See more about Mitch here: https://www.mitchhorowitz.com/

This lesson talks about the last batch of verbal focus, namely: Benefactive (which uses the I- or IPAG- prefixes), Instrumental (which uses the IPANG-, IPAM- or IPAN- prefixes), and Causative/ Rational (which uses the IKA- prefix).A heartfelt appreciation to my $5 Patrons mentioned as of this recording:Craig Putz, Isak Buan, Gladys Trinidad, Ken Yeager, Paolo de Armas, Christian Dimalanta, J Springy, Elaine, Bryan, Melinda O’Connor, Caroline Jane Walsh, Alex, Chris, Alexander Ong, Niña Lerch, Kirstie, Steph, Ollie Crouch, Natasha Esguerra, Jon Bailey, Roger Schachtel, Theresa Salud, and Shane.Support my podcast for as little as $1 a month: https://www.patreon.com/gofilipinopodBuy my merch: https://www.teepublic.com/user/gofilipinopodFollow this podcast on Twitter, Facebook, and Instagram: @gofilipinopod. For inquiries, send me an email: gofilipinopod@gmail.comSpecial thanks to "Rainbows" by Kevin MacLeod.

A while ago we looked at the causative form of the verb make. Today, I’d like to dig a little deeper into the different ways we can use this very versatile verb, MAKE. Here are the example sentences. To get the details of this English lesson, you need to listen to the podcast or check the transcript for the details. ... Read More

Join us for episode 6 of The Creative Soul Podcast where our hosts @Jesskaapproved and @Leonsays create Causative, Cultural conversations about Culture. --- Support this podcast: https://podcasters.spotify.com/pod/show/creativesoulpodcast/support

Causative Verbs | Inglês Avançado Use o código teacherca para fazer uma aula de inglês grátis no Cambly.* Link: bit.ly/cambly_subcribe Faça uma aula com a nossa professora nativa de inglês Kae: https://www.cambly.com/en/student/tutors/Kae.T TESTE DE NIVELAMENTO: brasil.cambly.com/nivelamento-de-ingles-online/ Ou Baixe o nosso app: Apple Store: bit.ly/cambly-applestore Google Play: bit.ly/cambly-googleplay Acesse também o nosso podcast no YOUTUBE: https://youtu.be/IKS3i92g-p8 Ep.131 - Causative Verbs | Inglês Avançado Aula com um tutor nativo em inglês, dedicada a quem deseja aprender avançado! Saiba com um professor nativo sobre o uso dos Causative Verbs! English Conversation Classes! Assista essa aula de inglês grátis com professor nativo! * o código teacherca é válido apenas para novos alunos.

Creative SouL Podcast Episode 3 With hosts Leon Williamson and Jessyka Castillo, they discuss Causative, Cultural conversations from Tory Lanez to Breonna Taylor. #CreativeSoulPodcast --- Support this podcast: https://podcasters.spotify.com/pod/show/creativesoulpodcast/support

What does the word “freedom” mean to T.K. Coleman, director of entrepreneurial education at the Foundation for Economic Foundation (FEE) and the co-founder and education director at Praxis? “Recognizing that I have the permission and the power to be the predominant creative force in my own life,” he said. “It's understanding that power does not begin with a discussion of external realities. It begins with an affirmation of internal reality, that I am not powerful because I happen to have the president that I want. I am not powerful because it happens to be the case that my circumstances agree with me.  “I am powerful because I choose to be a causative force in my own experience. I am powerful because I choose to be an individual who has an impact on his world without asking anyone or anything for permission. I am powerful because it is a state of mind.” Listen to the full episode to learn more.

Link to bioRxiv paper: http://biorxiv.org/cgi/content/short/2020.08.05.238162v1?rss=1 Authors: Shi, Q., Jiang, X., Zhang, Y., Gao, J., Zhang, H., Ali, A., Zhao, D., Bao, J., Iqbal, F., Jiang, L. Abstract: Exploring the genetic basis of human infertility is currently under intensive investigation. However, only a handful of genes are validated in animal models as disease-causing genes in infertile men. Thus, to better understand the genetic basis of spermatogenesis in human and to bridge the knowledge gap between human and other animal species, we have constructed FertilityOnline database, which is a resource that integrates the functional genes reported in literature related to spermatogenesis into an existing spermatogenic database, SpermatogenesisOnline 1.0. Additional features like functional annotation and statistical analysis of genetic variants of human genes, are also incorporated into FertilityOnline. By searching this database, users can focus on the top candidate genes associated with infertility and can perform enrichment analysis to instantly refine the number of candidates in a user-friendly web interface. Clinical validation of this database is established by the identification of novel causative mutations in SYCE1 and STAG3 in azoospermia men. In conclusion, FertilityOnline is not only an integrated resource for analysis of spermatogenic genes, but also a useful tool that facilitates to study underlying genetic basis of male infertility. Availability: FertilityOnline can be freely accessed at http://mcg.ustc.edu.cn/bsc/spermgenes2.0/index.html. Copy rights belong to original authors. Visit the link for more info

Link to bioRxiv paper: http://biorxiv.org/cgi/content/short/2020.08.03.232926v1?rss=1 Authors: Bengani, H., Grozeva, D., Moyon, L., Bhatia, S., Louros, S. R., Hope, J., Jackson, A., Prendergast, J., Owen, L. J., Naville, M., Rainger, J., Grimes, G., Halachev, M., Murphy, L. C., Boskovic, O. S., Heyningen, V. v., Kind, P., Abbott, C. M., Osterweil, E., Raymond, L., Roest Crollius, H., FitzPatrick, D. Abstract: Undiagnosed neurodevelopmental disease is significantly associated with rare variants in cis-regulatory elements (CRE) but demonstrating causality is challenging as target gene consequences may differ from a causative variant affecting the coding region. Here, we address this challenge by applying a procedure to discriminate likely diagnostic regulatory variants from those of neutral/low-penetrant effect. We identified six rare CRE variants using targeted and whole genome sequencing in 48 unrelated males with apparent X-linked intellectual disability (XLID) but without detectable coding region variants. These variants segregated appropriately in families and altered conserved bases in predicted CRE targeting known XLID genes. Three were unique and three were rare but too common to be plausibly causative for XLID. We compared the cis-regulatory activity of wild-type and mutant alleles in zebrafish embryos using dual-color fluorescent reporters. Two variants showed striking changes: one plausibly causative (FMR1CRE) and the other likely neutral/low-penetrant (TENM1CRE).These variants were knocked-in to mice and both altered embryonic neural expression of their target gene. Only Fmr1CRE mice showed disease-relevant behavioral defects. FMR1CRE is plausibly disease-associated resulting in complex misregulation of Fmr1/FMRP rather than loss-of-function. This is consistent both with absence of Fragile X syndrome in the probands and the observed electrophysiological anomalies in the FMR1CRE mouse brain. Although disruption of in vivo patterns of endogenous gene expression in disease-relevant tissues by CRE variants cannot be used as strong evidence for Mendelian disease association, in conjunction with extreme rarity in human populations and with relevant knock-in mouse phenotypes, such variants can become likely pathogenic. Copy rights belong to original authors. Visit the link for more info

Link to bioRxiv paper: http://biorxiv.org/cgi/content/short/2020.07.08.181958v1?rss=1 Authors: Nicole Mariani, Alessandra Borsini, Charlotte A.M. Cecil, Janine F. Felix, Sylvain Sebert, Annamaria Cattaneo, Esther Walton, Yuri Milaneschi, Guy Cochrane, Clara Amid, Jeena Rajan, Juliette Giacobbe, Yolanda Sanz, Ana Agustí, Tania Sorg, Yann Herault, Jouko Miettunen, Priyanka Parmar, Nadia Cattane, Vincent Jaddoe, Jyrki Lötjönen, Carme Buisan, Miguel A. González Ballester, Gemma Piella, Josep L. Gelpi, Femke Lamers, Brenda WJH Penninx, Henning Tiemeier, Malte von Tottleben, Rainer Thiel, Katharina F. Heil, Marjo-Riitta Järvelin, Carmine Pariante, Isabelle M. Mansuy, Karim Lekadir Abstract: Introduction Depression, cardiovascular diseases and diabetes are among the major non-communicable diseases, leading to significant disability and mortality worldwide. These diseases may share environmental and genetic determinants associated with multimorbid patterns. Stressful early-life events are among the primary factors associated with the development of mental and physical diseases. However, possible causative mechanisms linking early life stress (ELS) with psycho-cardio-metabolic (PCM) multi-morbidity are not well understood. This prevents a full understanding of causal pathways towards shared risk of these diseases and the development of coordinated preventive and therapeutic interventions.Methods and analysis This paper describes the study protocol for EarlyCause, a large-scale and inter-disciplinary research project funded by the European Union's Horizon 2020 research and innovation programme. The project takes advantage of human longitudinal birth cohort data, animal studies and cellular models to test the hypothesis of shared mechanisms and molecular pathways by which ELS shape an individual's physical and mental health in adulthood. The study will research in detail how ELS converts into biological signals embedded simultaneously or sequentially in the brain, the cardiovascular and metabolic systems. The research will mainly focus on four biological processes including possible alterations of the epigenome, neuroendocrine system, inflammatome, and the gut microbiome. Life course models will integrate the role of modifying factors as sex, socioeconomics, and lifestyle with the goal to better identify groups at risk as well as inform promising strategies to reverse the possible mechanisms and/or reduce the impact of ELS on multi-morbidity development in high-risk individuals. These strategies will help better manage the impact of multi-morbidity on human health and the associated risk.Ethics and dissemination The study has been approved by the Ethics Board of the European Commission. The results will be published in peer-reviewed academic journals, and disseminated to and communicated with clinicians, patient organisations and media.Competing Interest StatementThe authors have declared no competing interest.View Full Text Copy rights belong to original authors. Visit the link for more info

Today it gives me great pleasure to interview Hay House published author Elizabeth Brown. Her story is remarkable and I know you will be fascinated. Elizabeth pioneered a unique, tailor-made, healing protocol called Causative Diagnosis. By accessing the information field of your body by use of DOWSING, she can determine

Maya Tiwari cautions listeners to tune-out of this particular podcast if experiencing depression, heartache, trauma, or feeling vulnerable. She traces the causes for transmutation of the human genome to the noxious and indiscriminate use of bio-chemical, bio-engineering, bio-herbicides military warfare of the last century. She collates the usage of these gases/chemicals to the timing of the diseases  (eg. Corona Virus, Spanish Flu, SARS, AIDS, Influenza) which are known for jumping the species barrier, spilling over to new host adaptations.Support the show (http://paypal.me/wiseearth)

Our ability to communicate is the bedrock of building and sustaining relationships. Yet many of us, and/or our loved ones experience difficulties speaking, expressing ourselves or understanding others, which may increase as we age. Causative factors may include muscle weakness, brain injuries, degenerative diseases, cancer, etc. Speech and language pathologists provide speech therapy which helps people experiencing difficulty regain and maximize speech and communication ability or develop strategies to compensate for persisting difficulties. They also help families, loved ones and friends learn how they can help to understand what is being said or help someone express themselves to their best ability. It's all about expressing our wants, needs, ideas and feelings. This is a fundamental human need. Don't let speech and/or communication deficits stop you, someone you care for, or someone you love.

Triangles is a simple meditation/visualization practice that can be fit into the busiest of schedules. Three people form a group and agree to link each day in thought. They visualize a triangle of light and goodwill being formed between each of the group members. The network as a whole, provides a real planetary service, anchoring the light, love, and goodwill of divinity into human consciousness. www.triangles.org Each Monday at 3:00 pm (New York), 8:00 pm (London), and 9:00 pm (Geneva) Triangles offers a webinar in cooperation with the global Triangles Meditation Group. The webinar aims to provide a platform for Triangles members and those who are new to Triangles to come together with others from around the world to give subjective support to the strengthening and expansion of the Triangles network. The webinar includes a short introductory talk about Triangles, a Triangles meditative visualization and a group sharing of ideas and impressions. To register for the webinar: https://www.lucistrust.org/triangles/webinar For transcripts of webinars follow the Triangles blog: https://www.lucistrust.org/blog_triangles

  Session 18 As always, I'm joined by Dr. Karen Shackelford from Board Vitals. If you haven't yet, check out Board Vitals and use the promo code BOARDROUNDS to save 15%. They have a huge database and question bank to help you get the practice you need to get the score that you need. [01:35] Question of the Week An older patient comes in with a painful rash. We have a 64-year-old female who presents complaining of a severe painful rash that is localized to the left side of her upper back and neck. She knows that the area of the rash feels hot and burning and extremely painful. She is otherwise healthy with no significant past medical history. On exam, her vital signs were within normal limits. And her exam is significant, primarily, because she has a large, red vesicular rash running along her left shoulder in confluent patches. She remarks that the lesions were smaller a few days ago and they quickly start to bubble over into larger 02:39. The physician performed a Tzanck smear to confirm her suspicions. She found the test to be positive for multinucleated giant cells. The patient will have which of the following characteristics? (A) Gram-positive, catalase-positive, beta-hemolytic and arranged in clusters (B) Branching pseudohyphae with budding yeast cells (C) Enveloped-virus with double-stranded DNA (D) Enveloped-virus with positive-strand RNA virus [04:30] Thought Process The correct answer is C. Varicella zoster virus would probably come to mind as well as shingles as the Tzanck smear showed multinucleated giant cells – herpes simplex virus 1 and 2 (HSV 1 and 2) as well as pemphigus vulgaris. Other findings you would probably see on the Tzanck smear would include acantholytic cell and keratinocyte ballooning. This test is not typically performed usually as a clinical diagnosis. But it can be performed in the office. The patient can be immunocompromised with atypical looking lesion or atypical presentation. So we'd think of herpes and varicella zoster. For the other answer choices, Choice A is Staphylococcus aureus, which isn't a choice for a skin infection. Choice B is a fungus. A fungal disease like Candida can cause a really nasty rash. But it won't be the vesicular nor the dermatomal, which this question suggests. Varicella zoster virus is latent in the sensory ganglion so it tends to erupt on one or two contiguous dermatomes, although it can erupt outside of the dermatome. But it's not going to be a big eruption and just one or two vesicles scattered somewhere else from reactivation of the viral particles. Option D is Rubella. It causes a rash and it's usually tested for IgM antibodies. If a test is needed, it's not the Tzanck smear. [07:45] Possible Question Points About the Herpes Virus About 30% of Americans will have it at some point in their lives coming from reactivation of the virus. It causes two clinically distinct diseases including chicken pox. Chicken pox would be characterized by vesicular lesions but they're on different stages of development. They're concentrated on the face and the trunk. It's an airborne virus that invades the lymphoid tissue in the nose or nasopharynx. The virus overcomes local host defenses. The epidermal cells usually react by making alpha-interferons. That's the incubation period. When the virus can overcome the local host defenses, then you've got a viremia. Then the virus downregulates your immune response through a variety of mechanisms, such as the inhibition of the expression of interferon response genes. When the virus remains latent for years in most cases, you're more at risk of reactivation as you get older because you have a diminished T-cell response. This is the same reason that people with immuno-compromise are more likely to erupt with shingles. It's a unilateral vesicular eruption, usually in the dermatome. The reactivated varicella can travel either way. It can travel peripherally through the sensory ganglion and go down the sensory nerve. This results in a skin infection or the characteristic rash. It can also reactivate and move centrally from the ganglion. This is seen in those who are severely immuno-compromised. But this results in some of the complications associated with herpes zoster like meningitis-encephalitis. Some of the syndromes include the Ramsay Hunt syndrome but it's a random thing. It occurs whenever the virus replicates in the geniculate ganglion. It travels down the 8th nerve and you have vesicles on the auricle or in the ear canal – ipsilateral facial paralysis. Herpes 11:12 is a pretty significant complication. You have to recognize it really early on because it can cause blindness. You can get herpes keratitis and acute retinal nephrosis. The treatment is going to be an antiviral ganciclovir or acyclovir. Postherpetic neuralgia is another big complication with severe significant pain (3 out of 10 and higher for about 90 days or more). Some people can have sensory changes. It can be intensely pruritic. If you get vesicular lesions on the nose then the nerve distribution is pretty worrisome so you have to be aware of that. [12:50] Board Vitals Check out Board Vitals and use the promo code BOARDROUNDS to save 15% off your QBank purchase. Whether you're studying for the COMPLEX or USMLE, Board Vitals has the QBank you need to help prepare you the best possible way. Links: Board Vitals (use the promo code BOARDROUNDS to save 15%)

Bisi Soji-oyawoye (CEO) and Dr. Folake Ouokum are two outstanding leaders from the John Maxwell Team. Don't miss listening to this episode packed with wisdom from each woman's transformation story! Learn how to BE Causative by becoming a change agent in your own life and in others lives. What is T's Takeaway? “If you cant change it, keep walking.”

You can get our textbooks and workbooks that you can use along with these audio lessons at our website http://TalkToMeInKorean.com. You can also download the accompanying PDF lesson notes for free.

Elizabeth Brown is a master dowser and author of DOWSING: The Ultimate Guide For The 21st Century. Her storied career includes the co-founding and running of a geopathic stress consultancy, she has studied with two former presidents of the British Society of dowsers, and has trained in remote viewing and more. Plus, she comes from a family lineage of water dowsers. In this episode, Elizabeth helps us understand the history and science behind dowsing including the sometimes surprising involvement of the Catholic Church. We discuss whether pendulums are as effective as rods, and the importance of finding your niche as a dowser. (We can't all be experts at everything, right?) She also explains what a session with her entails and helps me get a sense of what's affecting my nasal congestion.

Rima Slim, professeure agrégée à l’Institut de recherche de ce centre en parle au nom de ses collègues qui ont contribué à la recherche intitulée : Causative genes and mechanism of androgenetic hydratidiform moles, elle présente les résultats et leurs implications futures

Rec: November 4, 2018Pub: November 11, 2018 Call in at 865-268-4005 to leave your question or https://kudrinskrypt.com/contactOn this episode: My recent dungeon vacation and a listener question from Jr. Producer, Buffalodom84 about hygiene, then you and I are going to have a chat about self-care with a bonus topic of attitude and a quote that could change your life.The Woodshed, Orlando, FL, U.S.A., and Master Cecil.http://thewoodshedorlando.com/Rules to Love by:1: Safe, sane, consensual, and informed2: KNKI: Knowledge, No Intolerance, Kindness, Integrity3: “Submission is not about authority and it’s not about obedience; it is all about relationships of love and respect.” -Wm. Paul YoungHygiene:Jr. Producer Buffalodom84 wrote: “I just listened to your newest episode and had an idea for a new episode. Could you do an episode on hygiene?”What is hygiene?:Conditions and Practices that are to promote health including cleanliness, skin care, and the prevention of infections.Cleanliness Personal cleanlinessCleanliness of environmentCleanliness of FoodCleanliness of Food PreparationNicotine slows healing because it causes blood vessels to constrict, which decreases the amount of blood, oxygen, and nutrients to get to tissues which increases the chance of the breakdown of skin.Blood Clots-Signs and symptoms:RednessSwellingHeatPain sensation in the area of the clot.Usually happens in one extremityDo not do exercises- Go directly to Emergency Room!STI’s and Infections U.T.I.'s:Urinary Tract Infections: Pathogens in the urethra, vagina, or perineal area enter the urinary tract.Bacteria move up the ureters to the kidneys.Causative organisms: Escherichia coli, Staphylococcus, Saprophyticus, Proteus, Klebsiella, Seratia, and PseudomonasSymptomsPainful urinationUrine has a foul odorCloudy urineFrequent urinationDon’t feel goodFlank PainFeverTreatment:1: Urinary specimen2: Antibiotic3: Finish antibioticHow poor hygiene can affect a person's life:1: Some people may find out that they are missing out on friends, job opportunities and partners because of something that no one had ever pointed out to them – their lack of better personal hygiene.2: Maybe in the past as a child, their personal habits were pointed out, but in a negative way. No one really took an interest in that person to tell them that they must groom themselves properly or at least try to.3: Some bad habits of people who have no concept of personal hygiene are apparent body odor, greasy skin, oily hair, bad breath, and clothing that is dirty or old. The sad part is most of these things can be remedied much quicker than a bad cold and yet, individuals walk around like this day after day and endure the misery bad hygiene often brings. The misery includes people who do not want to be near these people for the above reasons and the lost personal opportunities.Some ways people can start to improve is to take a realistic look at themselves in a full-length mirror. Even if it hurts to think about it, they should consider the advice of others, especially the people who are around every day.4: Individuals who are suffering from this should try to pinpoint what exactly can be improved, and ask themselves, “What would I really like to improve about myself that is available to me right now?”Show Support:1a: Executive Producers Jeremiah, Sihlus, Jess, and ArcaneDgr & violetaurelia. 1b: Sr. Producers Matt and xEmeraldxWolfx. 1c: Producers Kainsin, Heather, ThatPlace: Oklahoma City, JayKay and RoxieBear. 1d: Jr. Producers K-2SO, BuffaloDom84, Painwaits, and Master Ferguson & LxSoumis. If you would like to become one of our show producers go to our website, https://kuldrinskrypt.com/support to get that information.2: BDSM contracts for the donation of their beautiful 25 page soft and hardbound BDSM contracts. http://bdsmcontracts.org coupon code: kuldrin20 for a 20% discount on all purchases.3: http://whippingstripes.com my personal maker of leather and paracord impact toys. Self-care:“Self-care 101” By Maria Baratta Ph.D., L.C.S.W.https://www.psychologytoday.com/us/blog/skinny-revisited/201805/self-care-101What is self-care? Self-care, in essence, is the mindful taking time to pay attention to you, not in a narcissistic way, but in a way that ensures that you are being cared for by you. Ten ways to exercise self-care and take better care of you:1: Self-care means knowing who you are and your limits. Self-care means recognizing when you are doing more than you are used to handling and trying to figure out what can be done to slow down.2: Self-care means getting the sleep you need and knowing how to rest. Are you getting enough sleep for you? Do you know how much sleep you require every day and are you sleeping at least that much? Making a serious effort to make that happen as well as knowing how to rest your body and your mind are essential. 3: Self-care means making sure that you're well fed. Do you eat well—does what you eat provide the energy you need to function? Do you take time to eat meals at work and do you take time to have snacks when your body requires intermittent food during the workday? Self-care means integrating favorite healthy foods into your everyday eating routines and planning ahead to make sure you have adequate nutritious foods throughout your day.4: Self-care means finding a way to decompress throughout your day, not just when you leave work. What is it you do to rest your mind during and after a workday? What helps you tune out the noise? Most people tell me they don’t have the luxury of taking breaks during their workday but trying to integrate mini-breaks throughout the day helps refresh your mind and body. For example, try stretching or taking a brief walk even if it's only a few feet away, getting yourself a drink of water, talking to a friend, getting in touch with a loved one even if it's just a text, or purposely looking at photos that have special meaning. The brain needs those pauses. 5: Self-care means giving some thought to changing a difficult work situation. We know best what we need and what we can deal with. Is there anything that can be done to make your work somewhat less stressful? Think about whether changes can be made to your work environment. Are you okay with where you sit and do your work? Are you working unsustainable hours and is there some end in sight? It might be a matter of approaching a supervisor with things that you think may make your work more pleasant such as changing where you sit or changing whether you take an earlier lunch or later start time. Sometimes supervisors are not even aware of the reality of what the worker experiences in a workday. A frank conversation delineating the things that are most stressful might precipitate the process of improving your working conditions. People see the world through their own lenses and supervisors have their own problems and a sometimes a simple conversation can provide the insight they needed to rethink how things are done.6: Self-care means taking time to get to know you better. Self-care means learning to recognize your own temperament and trying to prepare for your personal limits. For example, do you have the trait of "high sensitivity? (Aron 1996) and if so, learning to recognize when you are experiencing sensory overload. "Highly Sensitives," "hsp's, " are particularly bothered and affected by over-stimulation and things like being hungry or tired or wearing uncomfortable shoes precipitate marked discomfort. Identifying your temperament and your triggers and planning accordingly might help lessen inevitable stress. That might be as simple as grabbing some almonds before a meeting that usually cuts into your lunch hour so you're not ridiculously hungry or rethinking fabulous but uncomfortable shoes. 7: Self-care means identifying what you enjoy doing and what's fun for you and make a serious effort to integrate it into your day or, at the very least, your week. Make it a habit to plan something to look forward to every day and that doesn't have to be complicated. It can be as simple as planning to read a good book at night or planning to have dinner with someone whose company you enjoy. 8: Self-care means knowing how to debrief from a day's work. That might mean walking home from work to clear your head, driving in silence or listening to music to help transition from work to home. 9: Self-care means feeding your spiritual self. That might take the form of meditating, praying, communing with nature by a walk in a park.10: And finally, self-care means taking time to love yourself and appreciating that there's only one you and you're the expert on that.What is self-care regarding BDSM?1: Knowing what you need for your own aftercare.2: Knowing how to recognize drop.3: Communicating needs.4: Admitting your personal limits.5: Recognizing when you can and can’t negotiate.“ATTITUDE” by Charles Swindoll"The longer I live, the more I realize the impact of attitude on life. Attitude, to me, is more important than facts. It is more important than the past, than education, than money, than circumstances, than failures, than successes, than what other people think, say or do. It is more important than appearance, giftedness or skill. It will make or break a company... a church... a home. The remarkable thing is we have a choice every day regarding the attitude we embrace for that day. We cannot change our past... we cannot change the fact that people will act in a certain way. We cannot change the inevitable. The only thing we can do is play the one string we have, and that is our attitude... I am convinced that life is 10% what happens to me and 90% how I react to it. And so it is with you... we are in charge of our Attitudes”Sir@kuldrinskrypt.comhttps://kuldrinskrypt.com

Rec: November 4, 2018Pub: November 11, 2018 Call in at 865-268-4005 to leave your question or https://kudrinskrypt.com/contactOn this episode: My recent dungeon vacation and a listener question from Jr. Producer, Buffalodom84 about hygiene, then you and I are going to have a chat about self-care with a bonus topic of attitude and a quote that could change your life.The Woodshed, Orlando, FL, U.S.A., and Master Cecil.http://thewoodshedorlando.com/Rules to Love by:1: Safe, sane, consensual, and informed2: KNKI: Knowledge, No Intolerance, Kindness, Integrity3: “Submission is not about authority and it’s not about obedience; it is all about relationships of love and respect.” -Wm. Paul YoungHygiene:Jr. Producer Buffalodom84 wrote: “I just listened to your newest episode and had an idea for a new episode. Could you do an episode on hygiene?”What is hygiene?:Conditions and Practices that are to promote health including cleanliness, skin care, and the prevention of infections.Cleanliness Personal cleanlinessCleanliness of environmentCleanliness of FoodCleanliness of Food PreparationNicotine slows healing because it causes blood vessels to constrict, which decreases the amount of blood, oxygen, and nutrients to get to tissues which increases the chance of the breakdown of skin.Blood Clots-Signs and symptoms:RednessSwellingHeatPain sensation in the area of the clot.Usually happens in one extremityDo not do exercises- Go directly to Emergency Room!STI’s and Infections U.T.I.'s:Urinary Tract Infections: Pathogens in the urethra, vagina, or perineal area enter the urinary tract.Bacteria move up the ureters to the kidneys.Causative organisms: Escherichia coli, Staphylococcus, Saprophyticus, Proteus, Klebsiella, Seratia, and PseudomonasSymptomsPainful urinationUrine has a foul odorCloudy urineFrequent urinationDon’t feel goodFlank PainFeverTreatment:1: Urinary specimen2: Antibiotic3: Finish antibioticHow poor hygiene can affect a person's life:1: Some people may find out that they are missing out on friends, job opportunities and partners because of something that no one had ever pointed out to them – their lack of better personal hygiene.2: Maybe in the past as a child, their personal habits were pointed out, but in a negative way. No one really took an interest in that person to tell them that they must groom themselves properly or at least try to.3: Some bad habits of people who have no concept of personal hygiene are apparent body odor, greasy skin, oily hair, bad breath, and clothing that is dirty or old. The sad part is most of these things can be remedied much quicker than a bad cold and yet, individuals walk around like this day after day and endure the misery bad hygiene often brings. The misery includes people who do not want to be near these people for the above reasons and the lost personal opportunities.Some ways people can start to improve is to take a realistic look at themselves in a full-length mirror. Even if it hurts to think about it, they should consider the advice of others, especially the people who are around every day.4: Individuals who are suffering from this should try to pinpoint what exactly can be improved, and ask themselves, “What would I really like to improve about myself that is available to me right now?”Show Support:1a: Executive Producers Jeremiah, Sihlus, Jess, and ArcaneDgr & violetaurelia. 1b: Sr. Producers Matt and xEmeraldxWolfx. 1c: Producers Kainsin, Heather, ThatPlace: Oklahoma City, JayKay and RoxieBear. 1d: Jr. Producers K-2SO, BuffaloDom84, Painwaits, and Master Ferguson & LxSoumis. If you would like to become one of our show producers go to our website, https://kuldrinskrypt.com/support to get that information.2: BDSM contracts for the donation of their beautiful 25 page soft and hardbound BDSM contracts. http://bdsmcontracts.org coupon code: kuldrin20 for a 20% discount on all purchases.3: http://whippingstripes.com my personal maker of leather and paracord impact toys. Self-care:“Self-care 101” By Maria Baratta Ph.D., L.C.S.W.https://www.psychologytoday.com/us/blog/skinny-revisited/201805/self-care-101What is self-care? Self-care, in essence, is the mindful taking time to pay attention to you, not in a narcissistic way, but in a way that ensures that you are being cared for by you. Ten ways to exercise self-care and take better care of you:1: Self-care means knowing who you are and your limits. Self-care means recognizing when you are doing more than you are used to handling and trying to figure out what can be done to slow down.2: Self-care means getting the sleep you need and knowing how to rest. Are you getting enough sleep for you? Do you know how much sleep you require every day and are you sleeping at least that much? Making a serious effort to make that happen as well as knowing how to rest your body and your mind are essential. 3: Self-care means making sure that you're well fed. Do you eat well—does what you eat provide the energy you need to function? Do you take time to eat meals at work and do you take time to have snacks when your body requires intermittent food during the workday? Self-care means integrating favorite healthy foods into your everyday eating routines and planning ahead to make sure you have adequate nutritious foods throughout your day.4: Self-care means finding a way to decompress throughout your day, not just when you leave work. What is it you do to rest your mind during and after a workday? What helps you tune out the noise? Most people tell me they don’t have the luxury of taking breaks during their workday but trying to integrate mini-breaks throughout the day helps refresh your mind and body. For example, try stretching or taking a brief walk even if it's only a few feet away, getting yourself a drink of water, talking to a friend, getting in touch with a loved one even if it's just a text, or purposely looking at photos that have special meaning. The brain needs those pauses. 5: Self-care means giving some thought to changing a difficult work situation. We know best what we need and what we can deal with. Is there anything that can be done to make your work somewhat less stressful? Think about whether changes can be made to your work environment. Are you okay with where you sit and do your work? Are you working unsustainable hours and is there some end in sight? It might be a matter of approaching a supervisor with things that you think may make your work more pleasant such as changing where you sit or changing whether you take an earlier lunch or later start time. Sometimes supervisors are not even aware of the reality of what the worker experiences in a workday. A frank conversation delineating the things that are most stressful might precipitate the process of improving your working conditions. People see the world through their own lenses and supervisors have their own problems and a sometimes a simple conversation can provide the insight they needed to rethink how things are done.6: Self-care means taking time to get to know you better. Self-care means learning to recognize your own temperament and trying to prepare for your personal limits. For example, do you have the trait of "high sensitivity? (Aron 1996) and if so, learning to recognize when you are experiencing sensory overload. "Highly Sensitives," "hsp's, " are particularly bothered and affected by over-stimulation and things like being hungry or tired or wearing uncomfortable shoes precipitate marked discomfort. Identifying your temperament and your triggers and planning accordingly might help lessen inevitable stress. That might be as simple as grabbing some almonds before a meeting that usually cuts into your lunch hour so you're not ridiculously hungry or rethinking fabulous but uncomfortable shoes. 7: Self-care means identifying what you enjoy doing and what's fun for you and make a serious effort to integrate it into your day or, at the very least, your week. Make it a habit to plan something to look forward to every day and that doesn't have to be complicated. It can be as simple as planning to read a good book at night or planning to have dinner with someone whose company you enjoy. 8: Self-care means knowing how to debrief from a day's work. That might mean walking home from work to clear your head, driving in silence or listening to music to help transition from work to home. 9: Self-care means feeding your spiritual self. That might take the form of meditating, praying, communing with nature by a walk in a park.10: And finally, self-care means taking time to love yourself and appreciating that there's only one you and you're the expert on that.What is self-care regarding BDSM?1: Knowing what you need for your own aftercare.2: Knowing how to recognize drop.3: Communicating needs.4: Admitting your personal limits.5: Recognizing when you can and can’t negotiate.“ATTITUDE” by Charles Swindoll"The longer I live, the more I realize the impact of attitude on life. Attitude, to me, is more important than facts. It is more important than the past, than education, than money, than circumstances, than failures, than successes, than what other people think, say or do. It is more important than appearance, giftedness or skill. It will make or break a company... a church... a home. The remarkable thing is we have a choice every day regarding the attitude we embrace for that day. We cannot change our past... we cannot change the fact that people will act in a certain way. We cannot change the inevitable. The only thing we can do is play the one string we have, and that is our attitude... I am convinced that life is 10% what happens to me and 90% how I react to it. And so it is with you... we are in charge of our Attitudes”Sir@kuldrinskrypt.comhttps://kuldrinskrypt.com

Let's get it started! #movetothecenter #causative

Rev. Dr. Maxine Kaye, talk from November 19, 2017: - The Attitude of Gratitude is a powerful enhancer of good in every area, increasing our consciousness of the constant flow of Prosperity. - It is the Law of Radiation that signals to the Universe our willingness to let in a greater share of the Divine Bounty, rather any sense of attracting or drawing things to us. - It is our consciousness that goes before us, and a grateful heart establishes our lives in this steady Stream of Plenty.

Join Kara Mullane as she reads two selected AJIC Abstracts from Journal Oct 2017, Vol 45, No 10. Topics: Healthcare worker perspectives of their motivation to reduce health care-associate infections and Bacterial biofilm-based catheter-associated urinary tract infections: Causative pathogens and antibiotic resistance. As a follow up to the biofilm topic, if you are a biofilm expert and can speak to specifics on how to stunt biofilm formation on medical devices such as urinary catheters we want to interview you!  Please email: kara@infectionpreventionspotlight.com Subscribe and never miss and episode!

Please join Karen Thomas for this very informative interview with Dr. Michael Lipelt, DDS, ND, as they dive into many of the reasons why so many children with Autism commonly have tooth decay and dental issues. Learn what some of those causative factors are and what safe, natural solutions exist to care for them properly.

Make is an interesting verb. We have a lot of collocations and idioms that use make, like make money, make time, make a face and so on. There are also a lot of grammatical uses of make and that’s the focus of today’s learn English podcast. In this English lesson, we’re going to look at three different ways we use ... Read More

Make is an interesting verb. We have a lot of collocations and idioms that use make, like make money, make time, make a face and so on. There are also a lot of grammatical uses of make and that’s the focus of today’s learn English podcast. In this English lesson, we’re going to look at three different ways we use ... Read More

In this episode: Causative verbs Make, Let, Get, Help and Have Causative verbs Make, Let, Get, Help and Have Más podcasts para mejorar tu ingles en: http://www.inglespodcast.com/  More podcasts to improve your English at: http://www.inglespodcast.com/  Causative verbs cause something else to happen MAKE: to force someone to do something. - forzar Make + someone + verb Did someone make you wear that shirt? All British schools make their pupils wear a uniform. My dad made me apologize to the neighbour. The policeman made me pay a fine. Craig says he didn’t want to eat the chocolate; a little voice in his head made him eat it. My mum always made me eat up all my greens (greens = vegetables) LET: to allow someone to do something. - dar permiso let + someone + verb Reza let me play his violin. Craig let Reza use his new microphone. Craig wouldn’t let anyone share his bar of dark chocolate. My boss won't let me have a day off. My parents never let me stay out late when I was a kid. Craig won’t let you say anything bad about Mickey Mouse! GET: to convince someone to do something - convencer get + someone + to + verb I got my students to do the homework by giving them chocolate. What's a good way to get students to read more? The government are spending more money on TV ads to get people to vote. People have tried to get Craig to give up chocolate....in vain. Craig has tried to get Reza to shut up at times...in vain. The naughty children got another child to steal biscuits for them. HELP: to help someone do something - ayudar help + someone + verb / help + someone + to + verb Reza helps me (to) produce this podcast. What helps you (to) unwind? (to unwind - relajarse) Does chocolate help you (to) forget your problems? Will you help us (to) spread the word by recommending us to your friends? Do you think this podcast helps our listeners (to) improve their English? Reza and Craig will help you (to) improve your English and take it to the next level! HAVE: to give someone the responsibility to do something - dar alguien la responsibilidad have + someone + verb (see AIRC112 for the causative use of have) I'll have my lawyer send you the contract. I had my secretary book the hotel. Please have the waiter bring the wine list. We had the porter carry our bags up to the room. We’re having our son organise our anniversary celebration for us. Could you have the doorman hail a taxi for me, please? ...and now it's your turn to practise your English. Do you have a question for us or an idea for a future episode? Send us a voice message and tell us what you think. www.speakpipe.com/inglespodcast Send us an email with a comment or question to craig@inglespodcast.com or belfastreza@gmail.com. If you would like more detailed shownotes, go to https://www.patreon.com/inglespodcast Our lovely sponsors are: Lara Arlem Zara Heath Picazo Mamen Juan Leyva Galera sara Jarabo Corey Fineran from Ivy Envy Podcast Rafael Daniel Contreras Aladro Manuel Tarazona Jorge Raul On next week's episode: Dependent prepositions – verbs followed by a preposition The music in this podcast is by Pitx. The track is called 'See You Later'   Más podcasts para mejorar tu ingles en: http://www.inglespodcast.com/  More podcasts to improve your English at: http://www.inglespodcast.com/             

In this episode we're going to help you with the causative passive. Más podcasts para mejorar tu ingles en: http://www.inglespodcast.com/  More podcasts to improve your English at: http://www.inglespodcast.com/  Listener Feedback: email from Jaime from Alicante - Hi Reza and Craig. Thank you for the podcast. I listen every week. Please speak about the causative in English. I don’t understand when (I) have to use ‘get’ and when ‘have’? We spoke about the passive in general in episode 17  When did you get your hair cut? Reza didn’t cut his hair. Someone cut it for him. Causative - have/get + object + past participle He had/got his hair (object) cut (past participle) Change to the causative: She didn’t pierce her nose herself, she had her nose pierced. He didn’t paint his flat (himself)…he had his flat painted. We won’t cook our meals...We'll have our meals cooked They didn’t repair their washing machine….They had their washing machine repaired I didn’t alter my suit...…. (to take up the trousers/sleeves) - I had my suit altered. She didn’t clean her flat….She had her flat cleaned. He doesn’t service his car…He has his car serviced. I didn’t fix my computer….I had my computer fixed. You aren’t taking your own blood pressure...You're having your blood pressure taken. He didn’t frame that picture himself….he got that picture framed. He didn’t fill his tooth himself….He got his tooth filled. She wasn’t cleaning that rug…..She was having that rug cleaned. We ourselves hadn’t checked the gas installation…We'd had the gas installation checked. I haven’t revoked my own driving licence…I've had my driving licence revoked. I wouldn’t examine my injury...I'd have my injury examined. When was the last time you had your photo taken? Can you have your blood pressure taken in a pharmacy in your country? Would you ever consider having a tattoo done? What are the advantages of having your head completely shaved? Should we have our bags searched on all public transport for security reasons? How often do you get your hair cut? Did you have your tonsils (=amígdalas) taken out (when you were a child)? Have you ever thought about getting your ear pierced? Have you ever had your wallet/purse stolen? Have you ever had your inside leg measured? Have you ever had your palm read/fortune told? Will Reza ever finally get his flat done up (to do up - reformar)? Italki gives 100 italki credits (ITC) to each paying student For more information: inglespodcast.com/italki/   ...and now it's your turn to practise your English. Do you have a question for us or an idea for a future episode? Send us a voice message and tell us what you think. www.speakpipe.com/inglespodcast Send us an email with a comment or question to craig@inglespodcast.com or belfastreza@gmail.com. If you would like more detailed shownotes, go to https://www.patreon.com/inglespodcast Our 11 lovely sponsors are: Lara Arlem Zara Heath Picazo Mamen Juan Leyva Galera Sara Jarabo Corey Fineran from Ivy Envy Podcast Jorge Jiménez Raul Lopez Rafael Daniel Contreras Aladro Manuel Tarazona On next week's episode: Causative verbs Make, Let, Get, Help and Have The music in this podcast is by Pitx. The track is called 'See You Later'   Más podcasts para mejorar tu ingles en: http://www.inglespodcast.com/  More podcasts to improve your English at: http://www.inglespodcast.com/          

Top of Show Greeting: Zametulian Announcements Radio West interview and Video West feature of Trent Pehrson The Art of Language Invention (George’s review, William’s review) Links and Resources Lamoureaux, S. V. D. (2004). Applicative Constructions in Maasai. Linguistics, (August). Austin, P. K. (2005). Causative and applicative constructions in Australian Aboriginal Languages. The Dative and Related... Read more »

For today’s English lesson, lets have a look at using the causative form of let and have. Here are the example sentences. To get the details of this English lesson, you need to listen to the podcast or check the transcript for the details: Bob usually lets his children watch TV after they finish their homework. Tony let Jane buy ... Read More

For today’s English lesson, lets have a look at using the causative form of let and have. Here are the example sentences. To get the details of this English lesson, you need to listen to the podcast or check the transcript for the details: Bob usually lets his children watch TV after they finish their homework. Tony let Jane buy ... Read More

  Vincent and Michael speak with Katy Bosio about her research on pathogenesis, immunity, and vaccines against Franciscella tularensis, the causative agent of tularemia.

Sometimes, you’ll do anything for that special someone. Join us today for a lesson on love and the causative suffix. (intermediate)

Topics covered: Causative avec faire Present participle Au fur et à mesure Bonjour chers amis du français ! Êtes-vous prêts pour notre dernier épisode ? Nous aurons le plaisir d'être en compagnie de Valérie et Michelle aujourd’hui. So, I can assure you that we will be entertained to the very end. I hope you have taken the time you look over the lessons and to do the exercises. Don’t forget to take advantage of all the tools available on our website, including the flashcard and the pronunciation guide. That’s it for me ! I leave you with Valérie et Michelle ! Les voilà ensemble pour la dernière fois !

Dr. Nirmala Gonsalves discusses her manuscript "Elimination Diet Effectively Treats Eosinophilic Esophagitis in Adults; Food Reintroduction Identifies Causative Factors." To view the print version of this abstract go to bit.ly/KMgg19

Colloquium given April 27, 2012

Welcome to our "causative" lesson. In English, when you say that you "make something bigger" or "to make someone sit down", you need the verb "make" but in Korean, you can attach a single suffix to the verb and the verb can take on the causative meaning. For example, 녹다 means "to melt", and when you want to say "to make something melt", you can say 녹이다 instead of 녹다. Listen to this lesson to learn more about these suffixes, 이/히/리/기/우/구/추.

Level 7 Lesson 11 / Making Things Happen (Causative) (PDF)

5 September 2011 Conventional Western medicine tends to focus on symptoms and ignore the underlying causes of ill health. In this talk to the BSD's 2010 Conference, Elizabeth, author of 'Dowsing: The Ultimate Guide to the 21st Century', argues that dowsing is the ideal tool to investigate the other causative factors involved (47 mins, 33MB). visit Elizabeth's website: gentlepowers.com

Welcome to another exciting episode of "Wynn with Dogs!". This week’s guest is Jonathan Klein, LA based dog behaviorist. Jonathan has trained over 6000 dogs using the causative method of training. This method addressed the cause of behavior issues rather than the behavior itself, thus leading to lasting behavior changes. All of you listeners know that Raquel advocates consistent, patient, loving training rather than explosive, harsh, punishment driven training. Join us this week and get some insight from a dog trainer who is right up this alley. Explore, with Jonathan and Raquel, why harsh, dominance modes of training can actually exacerbate bad behavior. Learn ways to build your dog's confidence! Tune in this week and get more wonderful tools that will help you win with dogs! More details on this episode MP3 Podcast - The Causative Method of Training with Raquel Wynn

SUMMARY The scope of the present work was to provide an scientific overview of the actually state of canine genetics of hereditary diseases. Causative mutations, inheritance modes, breed disposition and incidence of the single genetic defects in the affected dog populations have been outlined. Additionally a special focus aims on the gathering of actually available genetic tests for respective hereditary diseases within different dog breeds. The present state of science covers 76 genetically characterized hereditary diseases of the dog (status: January, 2009). Their inheritance mode, genetic basis, pathophysiology, breed dispositions and genetic control are shown here in detail. Up to date, 61 DNA tests are available for canine hereditary diseases. A compendium of the actually available genetic tests for the affected breeds with different suppliers is included in the appendix of this work. In the sector of genome analysis and screening tests for dogs, high research activity can be observed. This contributes to the specific suitability of the species dog as an animal model for the investigation of human hereditary diseases. The partial considerable inbreeding of some dog breeds leads to the appearance of numerous monogenetic hereditary diseases which are mostly of recessive nature. In addition, research results of the last few years demonstrate that these diseases are phenotypical or even genotypical homologues to human hereditary diseases. The number of the dog´s identified genetic mutations, which are connected to hereditary diseases, has increased in the past years and will increase continuously in the next years. An application of the enlarged genetic research results is as well of interest to the human medicine, as to the stockbreeding. The application of molecular-genetic screening methods offers dog breeders the possibility to determine the genetic status of their breeding dogs, to select healthy animals and to minimize future hereditary defects. The incidence of hereditary diseases can be reduced using genetic screening tests on the breeding dogs before breeding, introducing DNA of breeding dogs from other populations and avoiding the inbreeding within different pedigrees of dogs. Since a couple of years numerous screening and breeding programmes and the generation of genotype data banks are an obligation within many associations of dog breeders. This might accelerate an offbreeding of hereditary defects. The rising quantity of genetic screening tests and further investigation of undecoded mutations, will allow researches to amplify the understanding in the wide field of the polygene diseases. Relieving the succeeding generations of pedigree dogs from monogene and polygene hereditary sufferings is the future aim.

The ZAP Express cDNA library was constructed using mRNA extracted from the triactinomyxon spores. First-strand cDNA was synthesized using Moloney Murine leukaemia virus reverse transcriptase. Following second-strand cDNA synthesis, the double-stranded cDNA was digested with Xho I restriction enzyme, cDNA fragments less than 400bp were removed and the remaining cDNA was ligated with the lambda ZAP Express vector. The recombinants were packaged in vitro using Gigapack III gold packaging extract. The primary cDNA library titre contained 0.5 X 106 clones, with 97% recombinant and only 3% non-recombinant clones. The cDNA library was then screened using the anti-triactinomyxon antibodies. Positive clones were selected and re-screened twice more to give a final selection of 526 clones. One clone (46-5) was selected randomly and subjected to in vivo excision of the pBK-CMV phagemid from the ZAP express vector. The sequence of the entire clone was obtained using rapid amplification of the cDNA ends. A search of the clone sequence against GenBank revealed that it related to ribosomal protein L23 and it had a high percentage similarity to this protein from different species. A conserved domain for ribosomal protein L23 was also identified in the clone sequence