Podcasts about Crackpots

Harnessing the Power of Storytelling in Business with Dr. Danny BrassellOn this episode of The Thoughtful Entrepreneur, host Josh Elledge chats with Dr. Danny Brassell, co-founder of The WellCrafted Workshop. Together, they explore how storytelling can fuel business growth, build authentic personal brands, and drive stronger audience engagement. Dr. Brassell shares his inspiring journey through journalism, education, and professional speaking—and explains why storytelling is at the heart of every successful communication strategy. Tune in to learn his signature "Five C's" framework and how to use it to make your message memorable and impactful.Clarity and Connection: The First Steps to a Strong StoryDr. Brassell explains that every great story starts with clarity. Entrepreneurs often assume their message should appeal to everyone, but in truth, defining a specific audience and the exact problem you solve makes your message far more compelling. He also highlights the importance of connection through vulnerability. Sharing personal challenges—alongside wins—builds trust and relatability. Audiences don't want perfection; they want to feel seen and understood. Your willingness to share failures can be your most powerful storytelling tool.Delivering Content That Engages and Inspires ActionOnce clarity and connection are established, your content needs to deliver real value. Dr. Brassell encourages storytellers to go beyond information-sharing—make your content engaging and educational. Every great story should also include a strong call to action. Be specific and direct. Guide your audience toward the next step—whether that's attending a workshop, booking a call, or downloading a free resource. And don't forget the close—a compelling conclusion that evokes emotion and reinforces your key message.Coaching Communicators and Inspiring Young ReadersBeyond speaking, Dr. Brassell now coaches professionals—from engineers in Silicon Valley to top corporate teams—helping them communicate with more confidence and clarity. His mission: transform presentations into meaningful conversations. He also recently published a new book, Misfits and Crackpots, created to uplift young readers with true stories of individuals who overcame obstacles to achieve extraordinary things. The book aims to offer a counterbalance to darker narratives in youth literature—giving kids role models who inspire and stories that spark hope.About Dr. Danny BrassellA highly sought-after speaker, trainer, and coach known as “Jim Carrey with a Ph.D.,” Dr. Danny Brassell (www.DannyBrassell.com) has spoken to over 3,500 audiences worldwide. He has authored 18 books, including Leadership Begins with Motivation and Misfits and Crackpots. As the co-founder of The WellCrafted Story Workshop™, Danny helps entrepreneurs, individuals, and organizations leverage speaking on stages as a major client lead source that converts.About The WellCrafted WorkshopThe WellCrafted Workshop provides coaching, workshops, and custom training programs to help professionals craft stories that connect, convert, and inspire. Their methodology is built to transform leaders into confident, clear communicators.Links Mentioned in this Episode

This is a catch-up version of James O'Brien's live, daily show on LBC Radio. To join the conversation call: 0345 60 60 973

Episode Summary: In this episode of the Work at Home Rockstar Podcast, Tim chats with the high-energy and inspiring Dr. Danny Brassell, co-founder of The WellCrafted Story Workshop™. Known as “Jim Carrey with a Ph.D.,” Danny shares how his journey through journalism, education, devastating financial loss, and reinvention as a speaker and storytelling coach led him to help entrepreneurs harness the power of story. You'll walk away from this episode with actionable tips to grow your business using compelling narratives, plus strategies to build resilience and amplify your voice. Who is Danny Brassell? Dr. Danny Brassell is a global keynote speaker, storytelling coach, and author of 19 books including Leadership Begins with Motivation and Misfits and Crackpots. With over 3,500 presentations delivered worldwide, he co-founded The WellCrafted Story Workshop™, a platform that empowers leaders to turn their personal experiences into stories that spark engagement and drive results. A former inner-city teacher, Danny blends educational expertise with practical business strategies. Connect with Danny Brassell: Website: https://www.dannybrassell.com Instagram: https://www.instagram.com/realDannyBrassell Facebook: https://www.facebook.com/DannyBrassell LinkedIn: https://www.linkedin.com/in/dannybrassell YouTube: https://www.youtube.com/DannyBrassell Twitter/X: https://twitter.com/DannyBrassell Host Contact Details: Website: https://workathomerockstar.com Facebook: https://www.facebook.com/workathomerockstar Instagram: https://www.instagram.com/workathomerockstar LinkedIn: https://www.linkedin.com/in/timmelanson YouTube: https://www.youtube.com/@WorkAtHomeRockStarPodcast Twitter/X: https://twitter.com/workathomestar Email: tim@workathomerockstar.com In this Episode: 00:01:00 From Journalist to Educator to Entrepreneur 00:02:24 Losing Everything in a Real Estate Scam – and the Pivot that Followed 00:04:47 The Truth About Storytelling and Business Growth 00:10:00 The “Bandaid” Story – a Masterclass in Humor & Presentation 00:23:18 Morning Routines and the Power of Thought Walks 00:33:01 Building a Scalable, Story-Driven Business

David Frum joins Mona to discuss Trump's Canada gripes, how tariffs will/are sabotaging America, NATO, defying court orders, and how best to counter all of it. Go to Hungryroot.com/CHAREN and use code CHAREN to get 40% off your first box and a free item of your choice for life. REFERENCES: Why Cede the Flag to Trump? by David Frum in The Atlantic (2017)

The Scrooge, Grinch, and Antiochus send you Christmas and Hanukkah Cheers. Explore TrueAnon episodes: podcast.trueanon.com Give the gift of TrueAnon: patreon.com/TrueAnonPod/gift Check out the Crackpots tier: patreon.com/TrueAnonPod/membership

Some things are ordered and some are chaotic. This story is neither. Check out: indeed.com/theconstant now to start hiring Visit our Patreon here. You too can get ad-free, early episodes, starting now!​​ BUY OUR MERCH, YOU FILTHY ANIMALS! The Constant is part of the Airwave Media podcast network.​​ ​​Interested in advertising on The Constant? Email sales@advertisecast.com to get on board! Learn more about your ad choices. Visit megaphone.fm/adchoices

Today we have a deep dive into the absolute havoc SCOTUS's immunity ruling will wreak in Trump's document theft case — even though he was out of the White House when he committed his crimes! But first, the election denying weirdos and their election denying lawyers are Froot Looping all over the docket in the Dominion defamation case. And for subscribers: a discussion of the Alex Jones bankruptcy debacle.   Links: 18 USC 333 https://www.law.cornell.edu/uscode/text/18/333 John Case in 2015 https://www.evanscase.com/john-case-senior-partner-at-evans-case-llp-attorney-named-colorado-super-lawyer/ John Case today https://www.johncaselaw.com/ Trump v. US https://www.supremecourt.gov/opinions/23pdf/23-939_e2pg.pdf 18 USC 793 https://www.law.cornell.edu/uscode/text/18/793 Trump SDFL Motion to Dismiss for Selective and Vindictive Prosecution https://storage.courtlistener.com/recap/gov.uscourts.flsd.648653/gov.uscourts.flsd.648653.508.0.pdf Alex Jones bankruptcy docket https://www.courtlistener.com/docket/66583024/alexander-e-jones-and-official-committee-of-unsecured-creditors/?filed_after=&filed_before=&entry_gte=&entry_lte=&order_by=desc Alex Jones Ch. 7 Trustee Emergency Motion https://storage.courtlistener.com/recap/gov.uscourts.txsb.459750/gov.uscourts.txsb.459750.720.0_1.pdf Show Links: https://www.lawandchaospod.com/ BlueSky: @LawAndChaosPod Threads: @LawAndChaosPod Twitter: @LawAndChaosPod Patreon: patreon.com/LawAndChaosPod  

On this week's Ruminant, Jonah drinks coffee and remembers things. Topics include his thoughts on the newest installment of the Mad Max franchise, Donald Trump's karmic retribution, and a Muslim exotic dancer named Lulu. He also touches on the state (or lack thereof) of the alt-right, and responds to the critiques of Wednesday's G-File. Show Notes —Chris Hemsworth's Prosthetic Nose —Trump's Guilty Verdict (and the subsequent reactions) —Auditions for Trump's VP Ticket —“Radical Chic” Politics —Wednesday's G-File —The Rise and Fall of the Alt-Right —Why Islam needs a Pope —Bigotry and Crackpots on the Right —Bigotry and Crackpots on the Right Learn more about your ad choices. Visit megaphone.fm/adchoices

Professor Venki Ramakrishnan, a Nobel laureate for his work on unraveling the structure of function of the ribosome, has written a new book WHY WE DIE which is outstanding. Among many posts and recognitions for his extraordinary work in molecular biology, Venki has been President of the Royal Society, knighted in 2012, and was made a Member of the Order of Merit in 2022. He is a group leader at the MRC Laboratory of Molecular Biology research institute in Cambridge, UK.A brief video snippet of our conversation below. Full videos of all Ground Truths podcasts can be seen on YouTube here. The audios are available on Apple and Spotify.Transcript with links to audio and external linksEric Topol (00:06):Hello, this is Eric Topol with Ground Truths, and I have a really special guest today, Professor Venki Ramakrishnan from Cambridge who heads up the MRC Laboratory of Molecular Biology, and I think as you know a Nobel laureate for his seminal work on ribosomes. So thank you, welcome.Venki Ramakrishnan (00:29):Thank you. I just want to say that I'm not the head of the lab. I'm simply a staff member here.Eric Topol (00:38):Right. No, I don't want to give you more authority than you have, so that was certainly not implied. But today we're here to talk about this amazing book, Why We Die, which is a very provocative title and it mainly gets into the biology of aging, which Venki is especially well suited to be giving us a guided tour and his interpretations and views. And I read this book with fascination, Venki. I have three pages of typed notes from your book.The Compression of MorbidityEric Topol (01:13):And we could talk obviously for hours, but this is fascinating delving into this hot area, as you know, very hot area of aging. So I thought I'd start off more towards the end of the book where you kind of get philosophical into the ethics. And there this famous concept by James Fries of compression of morbidity that's been circulating for well over two decades. That's really the big question about all this aging effort. So maybe you could give us, do you think there is evidence for compression of morbidity so that you can just extend healthy aging and then you just fall off the cliff?Venki Ramakrishnan (02:00):I think that's the goal of most of the sort of what I call the saner end of the aging research community is to improve our health span. That is the number of years we have healthy lives, not so much to extend lifespan, which is how long we live. And the idea is that you take those years that we now spend in poor health or decrepitude and compress them down to just very short time, so you're healthy almost your entire life, and then suddenly go into a rapid decline and die. Now Fries who actually coined that term compression or morbidity compares this to the One-Hoss Shay after poem by Oliver Wendell Holmes from the 19th century, which is about this horse carriage that was designed so perfectly that all its parts wore out equally. And so, a farmer was riding along in this carriage one minute, and the next minute he found himself on the ground surrounded by a heap of dust, which was the entire carriage that had disintegrated.Venki Ramakrishnan (03:09):So the question I would ask is, if you are healthy and everything about you is healthy, why would you suddenly go into decline? And it's a fair question. And every advance we've made that has kept us healthier in one respect or another. For example, tackling diabetes or tackling heart disease has also extended our lifespan. So people are not living a bigger fraction of their lives healthily now, even though we're living longer. So the result is we're spending the same or even more number of years with one or more health problems in our old age. And you can see that in the explosion of nursing homes and care homes in almost all western countries. And as you know, they were big factors in Covid deaths. So I'm not sure it can be accomplished. I think that if we push forward with health, we're also going to extend our lifespan.Venki Ramakrishnan (04:17):Now the argument against that comes from studies of these, so-called super centenarians and semi super centenarians. These are people who live to be over 105 or 110. And Tom Perls who runs the New England study of centenarians has published findings which show that these supercentenarians live extraordinarily healthy lives for most of their life and undergo rapid decline and then die. So that's almost exactly what we would want. So they have somehow accomplished compression of morbidity. Now, I would say there are two problems with that. One is, I don't know about the data sample size. The number of people who live over 110 is very, very small. The other is they may be benefiting from their own unique genetics. So they may have a particular combination of genetics against a broad genetic background that's unique to each person. So I'm not sure it's a generally translatable thing, and it also may have to do with their particular life history and lifestyle. So I don't know how much of what we learned from these centenarians is going to be applicable to the population as a whole. And otherwise, I don't even know how this would be accomplished. Although some people feel there's a natural limit to our biology, which restricts our lifespan to about 115 or 120 years. Nobody has lived more than 122. And so, as we improve our health, we may come up against that natural limit. And so, you might get a compression of morbidity. I'm skeptical. I think it's an unsolved problem.Eric Topol (06:14):I think I'm with you about this, but there's a lot of conflation of the two concepts. One is to suppress age related diseases, and the other is to actually somehow modulate control the biologic aging process. And we lump it all together as you're getting at, which is one of the things I loved about your book is you really give a balanced view. You present the contrarians and the different perspectives, the perspective about people having age limits potentially much greater than 120, even though as you say, we haven't seen anyone live past 122 since 1997, so it's quite a long time. So this, I think, conflation of what we do today as far as things that will reduce heart disease or diabetes, that's age related diseases, that's very different than controlling the biologic aging process. Now getting into that, one of the things that's particularly alluring right now, my friend here in San Diego, Juan Carlos Belmonte, who went over from Salk, which surprised me to the Altos Labs, as you pointed on in the book.Venki Ramakrishnan (07:38):I'm not surprised. I mean, you have a huge salary and all the resources you want to carry out the same kind of research. I wouldn't blame any of these guys.Rejuvenating Animals With Yamanaka FactorsEric Topol (07:50):No, I understand. I understand. It's kind of like the LIV Golf tournament versus the PGA. It's pretty wild. At any rate, he's a good friend of mine, and I visited with him recently, and as you mentioned, he has over a hundred people working on this partial epigenetic reprogramming. And just so reviewing this for the uninitiated is giving the four Yamanaka transcription factors here to the whole animal or the mouse and rejuvenating old mice, essentially at least those with progeria. And then others have, as you point out in the book, done this with just old mice. So one of the things that strikes me about this, and in talking with him recently is it's going to be pretty hard to give these Yamanaka factors to a person, an intravenous infusion. So what are your thoughts about this rejuvenation of a whole person? What do you think?Venki Ramakrishnan (08:52):If I hadn't seen some of these papers would've been even more skeptical. But the data from, well, Belmonte's work was done initially on progeria mice. These are mice that age prematurely. And then people thought, well, they may not represent natural aging, and what you're doing is simply helping with some abnormal form of aging. But he and other groups have now done it with normal mice and observed similar effects. Now, I would say reprogramming is one way. It's a very exciting and powerful way to almost try to reverse aging because you're trying to take cells back developmentally. You're taking possibly fully differentiated cells back to stem cells and then helping regenerate tissue, which one of the problems as we age is we start losing stem cells. So we have stem cell depletion, so we can no longer replace our tissues as we do when we're younger. And I think anyone who knows who's had a scrape or been hurt in a fall or something knows this because if I fall and scrape my elbow and get a big bruise and my grandson falls, we repair our tissues at very, very different rates. It takes me days or weeks to recover, and my grandson's fine in two or three days. You can hardly see he had a scrape at all. So I think that's the thing that these guys want to do.Venki Ramakrishnan (10:48):And the problem is Yamanaka factors are cancer. Two of them are oncogenic factors, right? If you give Yamanaka factors to cells, you can take them all the way back to what are called pluripotent cells, which are the cells that are capable of forming any tissue in the body. So for example, a fertilized egg or an early embryo cells from the early embryo are pluripotent. They could form anything in the body. Now, if you do that to cells with Yamanaka factors, they often form teratomas, which are these unusual forms of cancer tumors. And so, I think there's a real risk. And so, what these guys say is, well, we'll give these factors transiently, so we'll only take the cells back a little ways and not all the way back to pluripotency. And that way if you start with skin cells, you'll get the progenitor stem cells for skin cells. And the problem with that is when you do it with a population, you're getting a distribution. Some of them will go back just a little, some of them may go back much more. And I don't know how to control all this. So I think it's very exciting research. And of course, if I were one of these guys, I would certainly want to carry on doing that research. But I don't think it's anywhere near ready for primetime in terms of giving it to human beings as a sort of anti-aging therapeutic.Aging and Cancer Shared HallmarksEric Topol (12:31):Yeah. Well, I couldn't agree more on that because this is a company that's raised billions of dollars to go into clinical trials. And the question that comes up here, which is a theme in the book and a theme with the aging process to try to artificially, if you will affect it, is this risk of cancer. And as we know, the hallmarks of aging overlap considerably with the hallmarks of cancer. And this is just one example, as you mentioned, where these transcription factors could result in generating cancer. But as you also point out in the book at many places, methylation changes, DNA, repair, and telomeres.Venki Ramakrishnan (13:21):And telomeres.Venki Ramakrishnan (13:24):All of those are related to cancer as well. And this was first pointed out to me by Titia de Lange, who's a world expert on telomeres at Rockefeller, and she was pointing out to me the intimate connection between cancer and aging and many mechanisms that have evolved to prevent cancer early in life tend to cause aging later in life, including a lot of DNA damage response, which sends cells into senescence and therefore causes aging. Buildup of senescence cells is a problem later in life with aging, but it has a role which is to prevent cancer early in life. And so, I think it's going to be the same problem with stem cell therapy. I think very targeted stem cell therapy, which is involved in replacing certain tissues, the kind of regenerative medicine that stem cells have been trying to address for a very long time, and only now we're beginning to see some of the successes of that. So it's been very slow, even when the goal and target is very specific and well-defined, and there you are using that stem cell to treat a pretty bad disease or some really serious problem. I think with aging, the idea that somebody might take this so they can live an extra 10 years, it's a much higher bar in terms of safety and long-term safety and efficacy. So I don't think that this is going to happen anytime soon, but it's not to say it'll never happen. There is some serious biology underlying it.Eric Topol (15:13):Right. Well, you just touched on this, but of course the other, there's several big areas that are being explored, and one of them is trying to deal with these senescent cells and trying to get rid of them from the body because they can secrete evil humors, if you will. And the problem with that, it seems that these senescent cells are sort of protective. They stop dividing, they're not going to become cancerous, although perhaps they could contribute to that in some way. So like you say, with telomeres and so many things that are trying to be manipulated here, there's this downside risk and it seems like this is what we're going to have to confront this. We have seen Venki with the CAR-T, the T-cell engineering, there's this small risk of engendering cancer while you're trying to deal with the immune system.SenolyticsVenki Ramakrishnan (16:07):Yeah, I think with senescent cells, the early in life senescent cells have an important role in biology. They're essentially signaling to the immune system that there's a site that's subject to viral infection or wounds or things like that. So it's a signal to send other kinds of cells there to come and repair the damage. Now, of course, that evolved to help us early in life. And also many senescent cells were a response to DNA damage. And that's again, a way for the body that if your DNA is damaged, you don't want that cell to be able to divide indefinitely because it could become cancerous. And so, you send it into senescence and get it out of harm's way. So early life, we were able to get rid of these senescent cells, we were able to come to the site and then clean up the damage and eventually destroy the senescent cells themselves.Venki Ramakrishnan (17:08):But as we get older, the response mechanisms also deteriorate with age. Our immune system deteriorates with age, all the natural signaling mechanisms deteriorate with age. And so, we get this buildup of senescent cells. And there people have asked, well, these senescent cells don't just sit there, they secrete inflammatory compounds, which originally was a feature, not a bug, but then it becomes a problem later in life. And so, people have found that if you target senescent cells in older animals, those animals improve their symptoms of aging improved dramatically or significantly anyway. And so, this has led to this whole field called senolytics, which is being able to specifically target senescent cells. Now there the problem is how would you design compounds that are highly specific for senescent cells and don't damage your other cells and don't have other long-term side effects? So again, I think it's a promising area, but a lot of work needs to be done to establish long-term safety and efficacy.Eric Topol (18:23):Right. No, in fact, just today in Nature, there's a feature on killing the zombie cells, and it discusses just what you're pointing out, which is it's not so easy to tag these specifically and target them, even though as you know, there's some early trials and things like diabetic macular edema. And we'll see how that plays out. Now, one of the things that comes up is the young blood story. So in the young blood, whether it's this parabiosis or however you want to get at it, and I guess it even applies to the young microbiome of a gut, but there's this consistent report that there's something special going on there. And of course the reciprocal relationship of giving the old blood to the young mice, whatever, but no one can find the factor, whether it's platelet factor 4, GDF11, or what are your thoughts about this young blood story?Venki Ramakrishnan (19:25):I think there's no question that the experiments work because they were reproduced and they were reproduced over quite a long period, and which is that when you connect an old mouse or rat with a young equivalent, then the old mouse or old rat benefits from the young blood from the younger animal. And conversely, the younger animal suffers from the blood from the older animal. And then people were wondering whether this is simply that the young animal has better detoxification and things like that, or whether it's actually the blood. And they gave it just as transfusion without connecting the animals and showed that it really was the blood. And so, this of course then leads to the question, well, what is it about young blood that's beneficial and what is it about old blood that is bad? But the problem is blood has hundreds of factors. And so, they have to look at which factors are significantly different, and they might be in such small quantities that you might not be able to detect those differences very easily.Venki Ramakrishnan (20:40):And then once you've detected differences, then you have to establish their mechanism of action. And first of all, you have to establish that the factor really is beneficial. Then you have to figure out how it works and what its potential side effects could be. And so again, this is a promising area where there's a lot of research, but it has not prevented people from jumping the gun. So in the United States, and I should say a lot of them in your state, California somehow seems to attract all these immortality types. Well, anyway, a lot of companies set up to take blood from young donors, extract the plasma and then give it to rich old recipients for a fee for a healthy fee. And I think the FDA actually shut down one of them on the grounds that they were not following approved procedure. And then they tried to start up under a different name. And then eventually, I don't know what happened, but at one point the CEO said something I thought was very amusing. He said, well, the problem with clinical trials is that they take too long. I'm afraid that's characteristic of some portion of this sort of anti-aging therapeutics community. There's a very mainstream rigorous side to it, but there's also at the other end of the spectrum, kind of the wild west where people just sell whatever they can. And I think this exploits people's fear of getting old and being disabled or things like that and then dying. And I think the fear seems to be stronger in California where people like their lives and don't want to age.Eric Topol (22:49):You may be right about that. I like your term in the book immortality merchants, and of course we'll get into a bit, I hope the chapter on the crackpots and prophets that you called it was great. But that quote, by the way, which was precious from, I think it was Ambrosia, the name of the company and the CEO, but there's another quote in the book I want to ask you about. Most scientists working on aging agree that dietary restriction can extend both healthy life and overall life in mice and also lead to reductions in cancer, diabetes, and overall mortality in humans. Is that true? Most scientists think that you can really change these age-related diseases.Caloric Restriction and Related PathwaysVenki Ramakrishnan (23:38):I think if you had to pick one area in which there's broad agreement, it is caloric restriction. But I wouldn't say the consensus is complete. And the reason I say that is that most of the comparisons are between animals that can eat as much as they want, called ad libitum diet and mice that are calorically restricted or same with other animals even yeast. You either compared with an extremely rich medium or in a calorically restricted medium. And this is not a great comparison. And people, there's one discrepancy, and that was in monkeys where an NIH study didn't find huge differences, whereas a Wisconsin study found rather dramatic differences between the control group and the calorically restricted group. And so, what was the difference? Well, the difference was that the NIH study, the controlled group didn't have a calorically restricted diet, but still had a pretty reasonable diet.Venki Ramakrishnan (24:50):It wasn't given a unhealthy rich diet of all you can eat. And then they tried to somehow reconcile their findings in a later study. But it leads to the question of whether what you can conclude is that a rich all you can eat diet, in other words, gorging on an all you can eat buffet is definitely bad for you. So that's why you could draw that conclusion rather than saying it's actually the caloric restriction. So I think people need to do a little more careful study. There was also a study on mice which took different strains of mice and showed that in some strains, caloric restriction actually shortened lifespan didn't increase lifespan. Now, much of the aging community says, ah, that's just one study. But nobody's actually shown whether there was anything wrong with that study or even tried to reproduce it. So I think that study still stands.Venki Ramakrishnan (25:51):So I think it's not completely clear, but the fact is that there's some calorie dependence that's widely been observed across species. So between the control group and the experimental group, whatever you may, however, you may define it as there's been some effective calories intake. And the other interesting thing is that one of the pathways affected by caloric restriction is the so-called TOR pathway and one of the inhibitors of the TOR pathways is rapamycin. And rapamycin in studies has also shown some of these beneficial effects against the symptoms of aging and in lifespan. Although rapamycin has the same issue as with many other remedies, it's an immunosuppressive drug and that means it makes you more prone to infection and wound healing and many other things. I believe one of them was there's a question of whether it affects your libido, but nevertheless, that has not prevented rapamycin clinics from opening up, did I say in California? So I do think that there's often serious science, which leads to sort of promising avenues. But then there are of course people who jump the gun and want to go ahead anyway because they figure by the time trials are done, they'll be dead and they'd rather try act now.Eric Topol (27:36):Right. And you make a good, I mean the rapamycin and mTOR pathway, you really developed that quite a bit in the book. It's really quite complex. I mean, this is a pleotropic intervention, whether it's a rapalogs or rapamycin, it's just not so simple at all.Venki Ramakrishnan (27:53):Right. It's not at all simple because the TOR pathway has so many consequences. It affects so many different processes in the cell from including my own field of protein synthesis. It's one of the things it does is shut down global protein synthesis, and that's one of the effects of inhibiting TOR. So, and it turns up autophagy, which is this recycling of defective proteins and entirely defective entire organelles. So I think the TOR pathway is like a hub in a very large network. And so, when you start playing with that, you're going to have multiple consequences.Eric Topol (28:37):Yeah, no. And another thing that you develop so well is about this garbage disposal waste disposal system, which is remarkably elaborate in the cell, whether it's the proteasome for the proteins and the autophagosome for the autophagy with the lysosomes and the mitochondria mitophagy. Do you want to comment about that? Because this is something I think a lot of people don't appreciate, that waste management in the cell is just, it's a big deal.Venki Ramakrishnan (29:10):So we always think of producing things in the cell as being important, making proteins and so on. But the fact is destroying proteins is equally important because sometimes you need proteins for a short time, then they've done their job and you need to get rid of them, or proteins become dysfunctional, they stop working, or even worse, they start clumping together and causing diseases for example you could think of Alzheimer's as a disease, which involves protein tangles. Of course, the relationship between the tangles and the disease is still being worked out, but it's a characteristic of Alzheimer's that you have these protein tangles and the cell has evolved very elaborate mechanisms to constantly turn over defective proteins. Well, for example, it senses when proteins are unfolded and essentially the chain has unraveled and is now sticking to all sorts of things and causing problems. So I think in all of these cases, the cells evolved very elaborate mechanisms to recycle defective products, to have proper turnover of proteins. And in fact, recycling of entire organelles like mitochondria, when they become defective, the whole mitochondria can be recycled. So these systems also break down with aging. And so, as we age, we have more of a tendency to accumulate unfolded proteins or to accumulate defective mitochondria. And it's one of the more serious problems with aging.Eric Topol (30:59):Yeah, there's quite a few of them. Unfortunately, quite a few problems. Each of them are being addressed. So there's many different shots on goal here. And as you also aptly point out, they're interconnected. So many of these things are not just standalone strategies. I do want to get your sense about another popular thing, especially here out in California, are the clocks, epigenetic clocks in particular. And these people are paying a few hundred dollars and getting their biologic age, which what is that? And they're also thinking that I can change my future by getting clocks. Some of these companies offer every few months to get a new clock. This is actually remarkable, and I wonder what your thoughts are about it.Venki Ramakrishnan (31:48):Well, again, this is an example of some serious biology and then people jumping the gun to use it. So the serious biology comes from the fact that we age at different rates individuals. So anyone who's been to a high school reunion knows this. You'll have classmates who are unrecognizable because they've aged so much and others who've hardly changed since you knew them in high school. So of course at my age, that's getting rarer and rarer. But anyway, but you know what I mean. So the thing is that, is there a way that we can ask on an individual level how much has that individual aged? And there are markers that people have identified, some of them are markers on our DNA, which you mentioned in California. Horvath is a very famous scientist who has a clock named after him actually, which has to do with methylation of our DNA and the patterns of methylation affect the pattern of gene expression.Venki Ramakrishnan (33:01):And that pattern changes as we age. And they've shown that those patterns are a better predictor of many of the factors of aging. For example, mortality or symptoms of aging. They're a better predictor of that than chronological age. And then of course there are blood markers, for example, levels of various blood enzymes or blood factors, and there are dozens of these factors. So there are many different tests of many different kinds of markers which look at aging. Now the problem is these all work on a population level and they also work on an individual level for time comparison. That is to say, if you want to ask is some intervention working? You could ask, how fast are these markers changing in this person without the intervention and how fast are they changing with the intervention? So for these kind of carefully controlled experiments, they work, but another case is, for example, glycosylation of proteins, especially proteins of your immune system.Venki Ramakrishnan (34:15):It turns out that adding sugar groups to your immune system changes with age and causes an immune system to misfire. And that's a symptom of aging. It's called inflammaging. So people have used different markers. Now the problem is these markers are not always consistent with each other because you may be perfectly fine in many respects, but by some particular marker you may be considered old just because they're comparing you to a population average. But how would you say one person said, look, we all lose height as we age, but that doesn't mean if you take a short person, you can consider them old. So it's a difference between an individual versus a population, and it's a difference between what happens to an individual by following that individual over time versus just taking an individual and comparing it to some population average. So that's one problem.Organ ClocksVenki Ramakrishnan (35:28):The other problem is that our aging is not homogeneous. So there's a recent paper from I believe Tony Wyss-Coray group, which talks about the age of different organs in the same person. And it turns out that our organs, and this is not just one paper, there are other papers as well. Our organs don't necessarily age at the same rate. So giving a single person, giving a person a single number saying, this is your biological age, it's not clear what that means. And I would say, alright, even if you do it, what are you going to do about it? What can you do about it knowing your biological, the so-called number of a biological age. So I'm not a big fan. I'm a big fan of using these markers as a tool in research to understand what interventions work because otherwise it would take too long. You'd have to wait 20 years to see some large scale symptoms. And certainly, if you want to look at mortality, you'd have to wait possibly even longer. But if you were to be able to follow track these interventions and see that these markers slowed down with intervention, then you could say, well, your interventions having an effect on something related to aging. So I would say these are very useful research tools, but they're not meant to be used at $500 a pop in your age.Venki Ramakrishnan (37:02):But of course that hasn't stopped lots of companies from doing it.Eric Topol (37:07):No, it's just amazing actually. And by the way, we interviewed Tony Wyss-Coray about the organ clock, the paper. I thought it really was quite a great contribution, again, on a research level.Venki Ramakrishnan (37:19):He's a very serious scientist. He actually spoke here at the LMB as well. He gave a very nice talk here.Is Aging A Disease?Eric Topol (37:26):He's the real deal. And I think that's going to help us to have that organ specific type of tracking is another edge here to understand the effects. Well, before we wrap up, I want to ask you a question that you asked in the book. Is aging a disease?Venki Ramakrishnan (37:49):That's again, a controversial subject. So the WHO, and I believe the FDA decided that aging was not a disease on the grounds that it's inevitable and ubiquitous. It happens to everybody and it's inevitable. So how could something that happens to everybody and inevitable be considered a disease? A disease is an abnormal situation. This is a normal situation, but the anti-aging researchers and especially the anti-aging therapeutics people don't like that because if it's not a disease, how can they run a clinical trial? So they want aging to be considered a disease. And their argument is that if you look at almost every condition of old age, every disease of old age like cancer, diabetes, heart disease, dementia, the biggest risk factor in all of these diseases is age. That's the strongest risk factor. And so, they say, well, actually, you could think of these diseases as secondary diseases, the primary disease being age, and then that results in these other diseases.Venki Ramakrishnan (39:07):I am a little skeptical of that idea. I tend to agree with the WHO and the FDA, but I can see both sides of the argument. And as you know, I've laid them both out. My view is that it should be possible to do trials that help with aging regardless of whether you consider aging a disease or not. But that will require the community to agree on what set of markers to use to characterize success. And that's people, for example, Tony Wyss-Coray has his proteome, blood proteome markers, Horvath has his DNA methylation clock. There are a whole bunch of these. And then there are people with glycation or glycosylation of various proteins as markers. These people need to all come together. Maybe we need to organize a nice conference for them in some place like Southern California or Hawaii or somewhere, put them together in a locked room for a week so that they can thrash out a common set of markers and at least agree on what experiments they need to do to even come to that agreement and then use that to evaluate anti-aging therapies. I think that would be a way forward.Eric Topol (40:35):Yeah, I think you're bringing up a really valuable point because at the moment, they're kind of competing with one another, whether it's the glycosylated proteins or the transcriptomics or the epigenetics. And we don't know whether these are additive or what they're really measuring.Venki Ramakrishnan (40:53):Some of them may be highly correlated, and that's okay, but I think they need to know that. And they also need to come up with some criteria of how do we define age in an individual. It's not one number, just like we have many things that characterize our health. Cholesterol is one, blood pressures another, various other lipids. They're all blood enzymes, liver enzymes. All these things are factors in defining our so-called biological health. So I don't think there's some single number that's going to say this is your age. Just like there isn't one single thing that says you're healthy, you're not healthy.DNA RepairEric Topol (41:38):Right, that's well put. Last topic on aging is on about DNA repair, which is an area that you know very well. And one of the quotes in your book, I think is important for people to take in. “Nevertheless, they will make an error once every million or so letters in a genome with a few billion letters. That means several thousand mistakes occur each time a cell divides. So the DNA repair enzyme, as you point out the sentinels of our genome, the better we repair, the better we age.” Can we fix the DNA repair problem?Venki Ramakrishnan (42:20):I think maybe, again, I'm not sure what the consequences would be and how much it would take. There's one curious fact, and that is that there was a paradox called Peto's paradox after the scientist who discovered it, which is why don't big animals get cancer much more frequently than say a mouse? In fact, a mouse gets cancer far more readily than an elephant does, and in reality, the elephant should actually get cancer more because it has many orders of magnitude more cells, and all it takes is for one cell to become cancerous for the animal to get cancer and die. So the chances that one cell would become cancer would be larger if there are many, many more cells. And it turns out that elephants have many copies of DNA repair proteins or DNA damage response proteins, not so much DNA repair, but the response to DNA damage and in particular, a protein called p53. And so, this leads to the question that if you had very good DNA repair or very good DNA damage response, would you then live longer or solve this problem? I'm not entirely sure because it may have other consequences because for example, you don't want to send cells into senescence too easily. So I think these things are all carefully balanced, evolutionarily, depending on what's optimized to optimize fitness for each species.Venki Ramakrishnan (44:13):For a mouse, the equation's different than for a large animal because a mouse can get eaten by predators and so on. So there, it doesn't pay for evolution to spend too much select for too much spending of resources in maintenance and repair, for larger animals the equation is different. So I just don't know enough about what the consequences would be.Eric Topol (44:40):No, it's really interesting to speculate because as you point out in the book, the elephant has 20 copies of p53, and we have two as humans. And the question is that protection from cancer is very intriguing, especially with the concerns that we've been talking about.Venki Ramakrishnan (44:57):And it was also true, I believe they did some analysis of genomics of these whales that live very long, and they found sorts of genes that are probably involved in DNA repair or DNA damage response.Eric Topol (45:14):Well, this is a masterful book. Congratulations, Venki. I thoroughly enjoyed it. It's very stimulating. I know a lot of the people that will listen or read the transcript will be grabbed by it.Crackpots and ProphetsVenki Ramakrishnan (45:28):I think what I've tried to do is give the general reader a real understanding of the biology of aging so that even a complete non-scientist can get an understanding of the processes, which in turn empowers them to take action to do the sort of things that will actually really help. And also it'll guard them against excessive hype, of which there's a lot in this business. And so, I think that was the goal, and to try and present a balanced view of the field. I'm merely trying to be a realist. I'm not being a pessimist about it, but I also think this excessively optimistic hype is actually bad for the field and bad for science and bad for the public as well.Eric Topol (46:16):Well, and you actually were very kind in the chapter you have on crackpots and prophets. You could have been even tougher on some of these guys. You were very relatively diplomatic and gentle, I thought, I don't know if you were holding back.Venki Ramakrishnan (46:28):I had two lawyers looked at it, so.Eric Topol (46:33):I believe it. And now one thing, apart from what we've been talking about because of your extraordinary contribution on the structural delineation of the ribosome back in the early 2000s and 2009 Nobel Prize. Now, the world of AI now with AlphaFold 3 and all these other large language models, would that have changed your efforts? Would that have accelerated things or is it not really?Venki Ramakrishnan (47:09):Well, it would've helped, but you would still need the experimental data to solve something like the ribosome, a large complex like the ribosome. And the other thing that would really change well has changed our world is the advent of cryo-electron microscopy of which Scripps is one of the leading places for it. And that has really changed it so that now nobody would bother to crystallize a ribosome and try to get an X-ray structure out of it. You would just throw it into an EM grid, collect your data and be off to the races. So new ribosome structures are being solved all the time at a fraction, a tiny fraction of the time it took to solve the first one.Eric Topol (48:02):Wow, that's fascinating. This has been a real joy for Venki to discuss your book and your work, and thanks so much for what you're doing to enlighten us and keep the balance. And it may not be as popular as the immortality merchants, but it's really important stuff.Venki Ramakrishnan (48:19):Yeah, no, I hope actually, I found that many of the public want to read about the biology of aging. They're curious. Humans have been curious ever since we knew about mortality, about why some species live so short lives and other species live such a long time and why we actually have to age and die. So there's natural curiosity and then it also empowers the public once they understand the basis of aging, to take action, to live healthy lives and do that. It's an empowering book rather than a recipe book.Venki Ramakrishnan (49:01):I think a lot of the public actually does appreciate that. And of course, scientists will like the sort of more balanced and tone.Eric Topol (49:13):Well, you do it so well. All throughout you have metaphors to help people really understand and the concepts, and I really applaud you for doing this. In fact, a couple of people who we both know, Max and John Brockman, apparently were influential for you to get to do it. So I think it's great that you took it on and all the power to you. So thank you, and I hope that we'll get a chance to visit further as we go forward.******************Headshot photo credits by Kate Joyce and Santa Fe InstituteThe Ground Truths newsletters and podcasts are all free, open-access, without ads.Please share this post/podcast with your friends and network if you found it informativeVoluntary paid subscriptions all go to support Scripps Research. Many thanks for that—they greatly helped fund our summer internship programs for 2023 and 2024.Thanks to my producer Jessica Nguyen and Sinjun Balabanoff tor audio and video support at Scripps Research.Note: you can select preferences to receive emails about newsletters, podcasts, or all I don't want to bother you with an email for content that you're not interested in.A Poll on Anti-Aging Get full access to Ground Truths at erictopol.substack.com/subscribe

Today we're publishing a talk Samo Burja gave to The Stoa in 2020 all about how to find and advance uncrystallized fields of knowledge. In this discussion, Samo critiques current academia for its inefficiencies and proposes supporting new intellectual endeavors with proper economic and social incentives. The discussion covers the potential for new academic structures, the role of social scenes in fostering innovation, and the need for a genuine pursuit of knowledge versus mere intelligence signaling. At the end, Samo answers questions from the audience to go deeper into the themes of the talk. -- LINKS: Samo's Bismarck Brief:  https://brief.bismarckanalysis.com/ -- FOLLOW US ON X: @eriktorenberg (Erik) @samoburja (Samo) @turpentinemedia (Turpentine) -- TIMESTAMPS: (00:00) Intro (00:29) Samo's Insightful Talk on Finding the Frontier of Knowledge (01:11) Navigating the Landscape of Knowledge and Institutions (03:20) The Role of Crackpots in Advancing Knowledge (05:11) Practical Steps Towards Identifying and Advancing in Your Field (07:20) Evaluating Institutions and Communities for Knowledge Advancement (11:40) Interactive Q&A: Connecting Knowledge Frontiers with Live Players (15:00) Debating the Viability of Competing with Current Academia (20:30) The Role of Super Connectors in Knowledge Domains (24:42) Live Players' Paths to Acquiring Knowledge (28:39) Exploring the Intersection of Science and Spirituality (29:29) Reviving Scenes and Cultural Renaissance (32:26) The Potential of Intellectual and Cultural Frontiers (34:32) Scenius, Knowledge Synthesis, and the Future of Intellectual Communities (38:46) Navigating the Meta Crisis Through Games and Biology (41:43) Rethinking Knowledge Production and Distribution (52:31) Envisioning a New Model for Intellectual Excellence (54:32) Final Reflections on Intellectual Authority and Responsibility (56:29) Wrap

Hold onto your tinfoil hats, Crackpots! Buckle up for a mind-bending rewind through Season 6 with your conspiracy comrades, Zach and Tim! This season finale extravaganza is like cracking open a vault of weirdness, where the guys spill the beans on: Deep dives that blew our minds: Relive the investigations that had you questioning everything from alien abductions to covert government operations! Curveballs that sent us spinning: Get ready for a hilarious (and maybe slightly terrifying) revisit of the surprises that left you scratching your heads! And brace yourselves for the moment you've all been waiting for... TWO MASSIVE ANNOUNCEMENTS that will blast Season 7 into the stratosphere (or maybe the hollow Earth, who knows?). ‌‌www.patreon.com/crackpotpodcast‌  

This month we're spurning classic Noirvember fare for a month devoted to its stressed spawn: the investigative paranoia thriller! We're starting with the middle chapter of Alan J Pakula's paranoia trilogy: THE PARALLAX VIEW from 1974!Parallax is the least celebrated of Pakula's paranoia trilogy films, but we here on the pod love it: its (unfortunately) timely themes, how it feels about corporations, and its absolutely wild visual presentation. We get into deep discussion on the Parallax test and whether Frady actually fits the profile, Pakula's thoughts on idea of Americana at the time and the lengths he went to to keep politics out of this movie, and we dip our toes into the deep dark waters of 1970's conspiracy theories.Plus, we LITERALLY define the word parallax. Is it our bleakest episode yet? Maybe! But it's all in good fun. We're not crackpots.

Robert F. Kennedy, Jr. has found the sweet spot in the horseshoe— between QAnon-ers waiting for JFK, Jr. and the weirdo, anti-vaxxers in the Dems. Plus, grifting tech bros, the likely malice behind No Labels, and Marco's relief that Trump is (probably) not a spy. Tim Miller joins Charlie Sykes for the weekend pod.  Learn more about your ad choices. Visit podcastchoices.com/adchoices

Robert F. Kennedy, Jr. has found the sweet spot in the horseshoe— between QAnon-ers waiting for JFK, Jr. and the weirdo, anti-vaxxers in the Dems. Plus, grifting tech bros, the likely malice behind No Labels, and Marco's relief that Trump is (probably) not a spy. Tim Miller joins Charlie Sykes for the weekend pod.  Learn more about your ad choices. Visit podcastchoices.com/adchoices

Breaking News!!! Top US Government Officials say Aliens are Real! Well, sort of. Listen along as I summarize this week's exciting Whistleblower Bombshell: the US and other nations around the world have been collecting ALIEN craft for decades in a clandestine Arms Race! No joke. Then, to add some comfort and solace to these incredible news stories I read you a cozy little story by our favorite Master of Horror, The Colour of Space...maybe not all alien visitors are tall, skinny, and look like they've taken way too many drugs as they cruised the Nevada Desert.https://share.newsbreak.com/43... by Brad Ledbetter, June 6, 2023https://TheDeBrief.org/intelli... by Leslie Keen & Ralph Blumenthal, June 5, 2023http://www.theguardian.com/wor... by Adam Gabbatt, June 6, 2023.http://www.newsnationnow.com/s...https://www.newsnationnow.com/...

In this conversation with Ferenc Laczó and Vera Scepanovic, Quinn Slobodian – author of the new book Crack-Up Capitalism: Market Radicals and the Dream of a World Without Democracy – discusses the unusual legal spaces and peculiar jurisdictions that have multiplied in recent decades and the libertarian ideas that propelled their rise; dissects the relationship of such zones to existing states and their sovereignty; shows how legal unevenness of contemporary globalization relates to earlier forms of imperial and colonial rule; and reflects on the more normative  elements of his critique and on the future of the zones in an age of ‘de-globalization.' Quinn Slobodian is a history professor at Wellesley College. Crack-Up Capitalism: Market Radicals and the Dream of a World Without Democracy has been published by Penguin.

Mark Levin. Silicon Valley Bank Filled with Lefty Crackpots, America Should Remain the #1 Superpower. We Didn't Start the Fire, Russia Did, China Did, Iran Did, North Korea Did. Mark Levin Podcast Mark Levin Audio Rewind  Mar 15 2023   On Wednesday's Mark Levin Show, Democrats are always about bailing out other Democrats and elite donors, but not every day Americans like the people in East Palestine, Ohio. The board of Silicon Valley Bank was filled with liberal crackpots pushing liberal causes like climate change and social justice, and in the end that was what ruined the bank. The Biden administration is destroying our economy and driving up inflation, because it is filled with people ideologues like OMB Director Shalanda Young lying about our deficit and national debt. President Biden is such a pathological liar, he is now accusing MAGA Republicans of wanting to defund the police because they didn't want to pass his so-called inflation reduction act, which is just a social justice and climate change bill. Biden says it's because he has no shame and has been lying for decades. Also, Marxists and populists are changing the language so if you believe that America should remain the #1 superpower and defend ourselves and our allies against the communist Chinese, fascistic Russians, or islamonazis in Iran, you're a liberal. Unless you oppose providing aid and support to allies and turn the other cheek while innocent people are being slaughtered at rates we haven't seen since World War 2, you're a warmonger. Later, Mark speaks with journalist James O'Keefe about his new venture in citizen journalism, O'Keefe Media Group.   Mark Levin is highly recommended by ACU. Mark Levin Podcast. Mark Levin Audio Rewind https://www.marklevinshow.com/audio-rewind/ You can download Mark Levin's podcasts in a number of ways: Subscribe to the podcasts through Apple Podcasts Subscribe to the podcasts through Google Podcasts Subscribe to the podcasts through Stitcher Subscribe to the podcasts through Spotify Subscribe to the podcasts through TuneIn Listen through Amazon Podcasts Subscribe to LevinTV YouTube: https://bit.ly/2YU9XXS Click here to check out Mark Levin's Facebook page: https://bit.ly/2XuTpp7 Click here to watch more Mark Levin on BlazeTV: https://bit.ly/3tIHmQM

Patriot and whistleblower Dr. Sam Sigoloff returns to SGT Report to shine the light of TRUTH and FACTS on the YouTube channel of a trial lawyer which CEO Susan Wojcicki probably loves. THIS is the kind of garbage one must spew to not only survive on YouTube, but also to be recommended by its crooked algorithms. WATCH this episode HERE: https://rumble.com/v21zd4e-crackpots-and-propagandists-dr.-sam-sigoloff.html

I Was A Communist For The FBI - A Riot Made To Order From-1952 Announcer-Truman Bradley Stars-Dana Andrews Matt Cvetic uses a sprinkler system to foil the plans of the Party to cause a riot and create sympathy for the Communists. Matt had heard people call members of the communist party in America harmless crackpots. He was one of those communists for nine years and reported their conspiracy against the United States from within. Crackpots? Like spiders spinning their webs. Harmless? Like tigers stalking their prey. 

Brian Regal is associate professor of the history of science at Kean University in New Jersey. He is the author of the recent Searching for Sasquatch: Crackpots, Eggheads, and Cryptozoology (Palgrave, 2011)******************************************************************To listen to all our XZBN shows, with our compliments go to: https://www.spreaker.com/user/xzoneradiotv*** AND NOW ***The ‘X' Zone TV Channel on SimulTV - www.simultv.comThe ‘X' Chronicles Newspaper - www.xchroniclesnewpaper.com

Limerick performer Jean McGlynn will be continuing the Halloween celebrations in Dolan's this year with her one-woman cabaret on November 3rd! 'VaudeVillains' is being described as “a Creepy Cabaret of Crackpots, Crooks and Criminals”... Hosted on Acast. See acast.com/privacy for more information.

Continuing a series on Cryptozoology by looking at a selection of the more notable hoaxes that dogged the community from day one. Ultimately though, many hoaxes turn out to be as hard to prove as hoaxes as they do the real deal… Bibliography coming soon, check out Jeff Meldrum's analysis of the Patterson-Gimlin prints here: https://youtu.be/VLL48HkSgqE, with special reference to ‘Searching for Sasquatch, Crackpots, Eggheads, and Cryptozoology' by Brian Regal and ‘The Locals, A Contemporary Investigation of the Bigfoot/Sasquatch Phenomenon' by Thom Powell. Inspired by fellow podcasters Bigfoot Club, Review It Yourself and The Nerdstalgic Podcast. Check them out. :-)

Continuing a series on Cryptozoology by exploring the second wave of ‘anomalous primate' research, and how it delineated itself and reacted to the expedition's that came before them. Exploring a few of the reactions to the ‘Yeti Hunting' craze and the directions anomalous primate researchers attempted to take the field, with examples from nemeses, Grover Krantz and René Dahinden. Bibliography coming soon, check out Jeff Meldrum's analysis of the Patterson-Gimlin prints here: https://youtu.be/VLL48HkSgqE, with special reference to ‘Searching for Sasquatch, Crackpots, Eggheads, and Cryptozoology' by Brian Regal and ‘The Locals, A Contemporary Investigation of the Bigfoot/Sasquatch Phenomenon' by Thom Powell. I nspired by fellow podcasters Bigfoot Club, Review It Yourself and The Nerdstalgic Podcast. Check them out. :-)

Continuing a series on Cryptozoology by beginning to explore the various contexts in which bipedal hominids are studied, starting with the Western Yeti craze of the 1950s and the tensions and motivations that informed the foundation the Pacific Northwest Sasquatch Expedition. Bibliography coming soon, check out Jeff Meldrum's analysis of the Patterson-Gimlin prints here: https://youtu.be/VLL48HkSgqE, with special reference to ‘Searching for Sasquatch, Crackpots, Eggheads, and Cryptozoology' by Brian Regal and ‘The Locals, A Contemporary Investigation of the Bigfoot/Sasquatch Phenomenon' by Thom Powell. Inspired by fellow podcasters Bigfoot Club, Review It Yourself and The Nerdstalgic Podcast. Check them out. :-)

GET 10% off the core Level Up Books at https://enpublishingrpg.com/discount/TTTRPG Use Code TTTRPG! (sponsored) More about Level Up Advanced 5th Edition: https://www.levelup5e.com/about - Level Up your D&D! ❤️ SUPPORT US and get Exclusive Perks! https://www.patreon.com/tabletoptime

Brian Regal is an associate professor of the history of science at Kean University in New Jersey. He is the author of the recent Searching for Sasquatch: Crackpots, Eggheads, and Cryptozoology (Palgrave, 2011)To listen to all our XZBN shows, with our compliments go to: https://www.spreaker.com/user/xzoneradiotv*** AND NOW ***The ‘X' Zone TV Channel on SimulTV - www.simultv.comThe ‘X' Chronicles Newspaper - www.xchroniclesnewpaper.com

We discuss West Wing Weekly's guest, Eli Attie, who was a Clinton/Gore speechwriter and West Wing writer. Do politicians really want what's best for their constituents? Kenny makes the case for firing Toby for insubordination. Jose couldn't care less about solecisms, but he is comforted in our Big Block of Cheese by sharing family stories. Links Jeremy Renner producing docuseries based off Oddie Blvd in Reno High Flight by John Gillespie Magee, Jr. Brooklyn: A Personal Memoir: With the lost photographs of David Attie The (Real) Story of the White House and the Big Block of Cheese whatsnextweekly.com has live links and an archive of past episodes

No matter how cracked you are God can make you a vessel of Honor --- Send in a voice message: https://anchor.fm/kip-nance/message Support this podcast: https://anchor.fm/kip-nance/support

Tuesday on the Stew Peters Show, Senator-in-exile Lauren Witzke and Edward Szall detail the shocking poisoning of the chief Russian peace envoy Roman Abramovich, and how a high profile death could start World War 3. Edward and Lauren also discuss the new information coming in from our southern border, that Mexican cartels are now hiding their narcotics in Crockpots turned Crackpots to evade drug dogs! Scott Rose exposes the discrimination he faced as an unvaxxed Covid patient, the fear tactics used by doctors, and the chronic kidney failure and continuous lung collapsing he now faces after being doses with remdesivir. And, America First financial expert Carlos Cortez Jr. addresses how to prepare and respond to the Biden regime's $5.8 trillion tax hike, bound to create a hellscape of inflation and economic turmoil. Visit Cortez Wealth Management to request a consultation: https://cortezwm.com/. Also visit America First Retirement Plan, to listen to Cortez's webinar and financial advice: https://americafirstretirementplan.com/. Don't miss a moment of Tuesday's edition of the Stew Peters Show, live on StewPeters.com Get Dr. Zelenko's Anti-Shedding Treatment, NOW AVAILABLE FOR KIDS: http://zStackProtocol.com Go Ad-Free, Get Exclusive Content, Become a Premium user: https://redvoicemedia.com/premium Follow Stew on Gab: https://gab.com/RealStewPeters See all of Stew's content at https://StewPeters.TV Watch full episodes here: https://redvoicemedia.net/stew-full-shows Check out Stew's store: http://StewPeters.shop Support our efforts to keep truth alive: https://www.redvoicemedia.com/support-red-voice-media/

In this episode, Dawn D. shares her experience, strength, and hope.Podcast Recovery is a forerunner in digitally accessible addiction recovery support. We provide ease and convenience to any and all seeking a message of recovery and hope. By broadcasting the stories of recovering addicts, we act as a complement to all other recovery services. We exist to create a global foundation platform, so that any addict may hear a message of strength and hope. We contribute education and awareness by highlighting the diversity in the lives of recovering addicts, to show that one addict helping another truly works.Please review, rate, and subscribe!!! Check out our website and social media accounts below.Join the Homegroup and support us on Patreon!!!https://www.patreon.com/bePatron?u=27296577Throw some money in the digital basketPaypal - https://paypal.me/podcastrecovery?locale.x=en_USCheck out our Social Media Accounts and Website for more content!www.podcastrecovery.comhttps://www.instagram.com/podcastrecovery/https://twitter.com/PodcastRecoveryhttps://www.facebook.com/Podcast-Recovery-208366179951769/https://www.facebook.com/groups/1905708653062608/https://www.youtube.com/channel/UC5YUmGN9HHlIkMyrND5lgpAIntro music by Lee Rosevere - Let's Start at the Beginning Outro music by Lee Rosevere - Going Homehttps://creativecommons.org/licenses/by/4.0/Support the show (https://paypal.me/podcastrecovery?locale.x=en_US)

Brian Regal is an associate professor of the history of science at Kean University in New Jersey. He is the author of the recent Searching for Sasquatch: Crackpots, Eggheads, and Cryptozoology (Palgrave, 2011)To listen to all our XZBN shows, with our compliments go to: https://www.spreaker.com/user/xzoneradiotv*** AND NOW ***The ‘X' Zone TV Channel on SimulTV - www.simultv.comThe ‘X' Chronicles Newspaper - www.xchroniclesnewpaper.com

Our crew today: Dr. Steph, Captain Jeff, and Producer Liz Pyper. Guest host Captain Dana. Join us for the latest in aviation news, your feedback, and this week's Plane Tale "Friedrich Karl von Koenig-Warthausen and the Crazy Baron!" Photo Credit: Nick Anderson [00:03:42] NEWS [00:04:01] Ethiopian Airlines Employees Hid in Roof Space of Passenger Plane in Daring Escape to the United States [00:10:39] West Atlantic AT72 at Guernsey and Jersey on Apr 16th 2021, Cargo Shift in Flight [00:18:33] Virgin Pilot Fired Over Claims He Took '40 winks' During Flight Wins £90,000 Payout [00:28:26] Student Pilot has STUCK FULL THROTTLE [00:48:51] Aerosucre B732 at Puerto Carreno on Feb 3rd 2022, Engine Failure on Takeoff [00:56:15] ‘Candy Bomber' of Berlin Blockade, Gail Halvorsen, Dies at 101 [00:59:02] GETTING TO KNOW US [01:36:43] COFFEE FUND [01:39:48] FEEDBACK [01:40:01] Jonathan - AA 1775 [01:54:52] PLANE TALE - Friedrich Karl von Koenig-Warthausen and the Crazy Baron! [02:17:45] Sean - Friendly Reminder: CBD [02:27:44] Carl - 509 - Lake in Iceland [02:30:06] Tim - F35 - Aircraft Carrier Crash [02:36:24] JJ Pittsburgh - Voiceovers and Quiz Shows [02:40:58] Andrew - Early Arrivals [02:45:18] Laura - Paragliding has Gone to the Dogs VIDEO Don't see the video? Click this to watch it on YouTube! ABOUT RADIO ROGER “Radio Roger” Stern has been a TV and Radio reporter since he was a teenager. He's won an Emmy award for his coverage in the New York City Market. Currently you can hear his reporting in New York on radio station 1010 WINS, the number one all-news station in the nation. Nationally you can hear him anchor newscasts on the Fox News Radio Network and on Fox's Headlines 24-7 service on Sirius XM Radio. In addition Roger is a proud member of and contributor to the APG community. Give us your review in iTunes! I'm "airlinepilotguy" on Facebook, and "airlinepilotguy" on Twitter. feedback@airlinepilotguy.com airlinepilotguy.com "Appify" the Airline Pilot Guy website (http://airlinepilotguy.com) on your phone or tablet! ATC audio from http://LiveATC.net Intro/outro Music, Coffee Fund theme music by Geoff Smith thegeoffsmith.com Dr. Steph's intro music by Nevil Bounds Capt Nick's intro music by Kevin from Norway (aka Kevski) Doh De Oh by Kevin MacLeod is licensed under a Creative Commons Attribution license (https://creativecommons.org/licenses/by/4.0/) Source: http://incompetech.com/music/royalty-free/index.html?isrc=USUAN1100255 Artist: http://incompetech.com/ Copyright © AirlinePilotGuy 2022, All Rights Reserved Airline Pilot Guy Show by Jeff Nielsen is licensed under a Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License

In this episode, Dara D. shares her experience, strength, and hope.Podcast Recovery is a forerunner in digitally accessible addiction recovery support. We provide ease and convenience to any and all seeking a message of recovery and hope. By broadcasting the stories of recovering addicts, we act as a complement to all other recovery services. We exist to create a global foundation platform, so that any addict may hear a message of strength and hope. We contribute education and awareness by highlighting the diversity in the lives of recovering addicts, to show that one addict helping another truly works.Please review, rate, and subscribe!!! Check out our website and social media accounts below.Join the Homegroup and support us on Patreon!!!https://www.patreon.com/bePatron?u=27296577Throw some money in the digital basketPaypal - https://paypal.me/podcastrecovery?locale.x=en_USCheck out our Social Media Accounts and Website for more content!www.podcastrecovery.comhttps://www.instagram.com/podcastrecovery/https://twitter.com/PodcastRecoveryhttps://www.facebook.com/Podcast-Recovery-208366179951769/https://www.facebook.com/groups/1905708653062608/https://www.youtube.com/channel/UC5YUmGN9HHlIkMyrND5lgpAIntro music by Lee Rosevere - Let's Start at the Beginning Outro music by Lee Rosevere - Going Homehttps://creativecommons.org/licenses/by/4.0/Support the show (https://paypal.me/podcastrecovery?locale.x=en_US)

This is an EXTENDED PREVIEW of the full two-hour episode, Calfire Crackpots 19: California Water Policy 2.0 (FEAT: Psychic Dolphin Garage Podcast!), so head on over to YouTube for the rest! ~~~~~~~~~~ The lovely folks over at the Calfire Crackpots podcast had Denis and Charlie over to talk all about California water politics! We were asked to bring our California ire and a big bucket of jokes. Never ones to disappoint, we grabbed our monkey's paw and together we made an episode 2-4x longer than usual and it was a freakin' blast! We cover everything from Silicon Valley grifts to the Governator and his state's ever-expanding, Mad Max water-theft canal system. Calfire Crackpots is a brand-spankin' new podcast (with slides!) about the natural world, water politics, and solutions to climate change. Please check out their YouTube channel and give 'em a like and a subscribe, and watch their other 18+ episodes! (I don't mean NSFW. I mean 18 other episodes, plus our 19th episode. It's a family show. Show it to your grandparents or a baby even without fear. But most importantly, show it to you, the listener who is reading this right now.) Check out the Calfire Crackpots YouTube Channel Force them to tweet and have Bad Brain like us by following them on Twitter! Send them an email at calfirecrackpots@gmail.com --- Send in a voice message: https://anchor.fm/psychicdolphingarage/message

Brian Regal is associate professor of the history of science at Kean University in New Jersey. He is the author of the recent Searching for Sasquatch: Crackpots, Eggheads, and Cryptozoology (Palgrave, 2011)******************************************************************To listen to all our XZBN shows, with our compliments go to: https://www.spreaker.com/user/xzoneradiotv*** AND NOW ***The ‘X' Zone TV Channel on SimulTV - www.simultv.comThe ‘X' Chronicles Newspaper - www.xchroniclesnewpaper.com

Brian Regal is associate professor of the history of science at Kean University in New Jersey. He is the author of the recent Searching for Sasquatch: Crackpots, Eggheads, and Cryptozoology (Palgrave, 2011) ****************************************************************** To listen to all our XZBN shows, with our compliments go to: https://www.spreaker.com/user/xzoneradiotv *** AND NOW *** The ‘X' Zone TV Channel on SimulTV - www.simultv.com The ‘X' Chronicles Newspaper - www.xchroniclesnewpaper.com

Brian Regal is associate professor of the history of science at Kean University in New Jersey. He is the author of the recent Searching for Sasquatch: Crackpots, Eggheads, and Cryptozoology (Palgrave, 2011) ****************************************************************** To listen to all our XZBN shows, with our compliments go to: https://www.spreaker.com/user/xzoneradiotv *** AND NOW *** The ‘X' Zone TV Channel on SimulTV - www.simultv.com The ‘X' Chronicles Newspaper - www.xchroniclesnewpaper.com

Brian Regal is associate professor of the history of science at Kean University in New Jersey. He is the author of the recent Searching for Sasquatch: Crackpots, Eggheads, and Cryptozoology (Palgrave, 2011)******************************************************************To listen to all our XZBN shows, with our compliments go to: https://www.spreaker.com/user/xzoneradiotv*** AND NOW ***The ‘X' Zone TV Channel on SimulTV - www.simultv.comThe ‘X' Chronicles Newspaper - www.xchroniclesnewpaper.com

Brian Regal is associate professor of the history of science at Kean University in New Jersey. He is the author of the recent Searching for Sasquatch: Crackpots, Eggheads, and Cryptozoology (Palgrave, 2011)******************************************************************To listen to all our XZBN shows, with our compliments go to: https://www.spreaker.com/user/xzoneradiotv*** AND NOW ***The ‘X' Zone TV Channel on SimulTV - www.simultv.comThe ‘X' Chronicles Newspaper - www.xchroniclesnewpaper.com

People too lazy or dense to educate themselves on the reality of an extraterrestrial presence on Earth are the true crackpots. --- Support this podcast: https://anchor.fm/james-quirk/support

Today on the Matt Walsh Show, Joe Biden picks a black supremacist to lead the DOJ's civil rights division. Also Five Headlines including Andrew Cuomo's lockdown 180, another democrat impeachment pageant, and Kamala Harris is persecuted because of a magazine cover photo in which she is wearing casual shoes. Learn more about your ad choices. Visit podcastchoices.com/adchoices

Subscribe to the podcast here. Listen on iTunes here. Listen on Spotify here. How much experience do you need in order to drop the impostor syndrome? CEO of Menslink Martin Fisk shares his three decades of leadership and answers the question this way, “do the best you can with what you've got'. I loved this interview! Martin has a unique perspective born of humility and deep conviction in his work. Enjoy the fabulous insights from culture to success to mental health.

Subscribe to the podcast here. Listen on iTunes here. Listen on Spotify here. Have you got people on your team who just don't seem to get along? They're at each other's throats? They rub each other up the wrong way? It's easy to think it's a personality conflict. The problem with THAT is that it makes us feel helpless: “Oh well, that's just the way they are.” The truth is more complex. The good news is that we can get beyond these challenges to build a better team, even with different personalities. 

Leadership can be a volatile experience. There are some seriously difficult situations - and people - to contend with. Cockups are what we fear most: failing and letting people down. Mistakes that are costly. Hurting people inadvertently. Perspective is the gateway to compassion: just because you cock things up, doesn't make you a c*ck - at least not permanently! Crackpots are a bigger concern. The biggest challenges is dealing with PSYCHOPATHS. Not all psychopaths are violent! Many are successful players in the corporate world. We need to know how to spot them, and how to deal with them. Conniptions are a surprise when they happen. When a crackpot pushes our buttons and all of a sudden we lose the plot, and default to behaviour that is out of the norm. Conniptions are rare occurrences, and yet we can learn from them.

How do you convince someone to change their perspective? If you want to move hearts and minds for a cause that is deeply meaningful to you, how do you do that? Sometimes the most passionate advocates end up doing more harm than good. Don't be fooled: passion is the worst form of persuasion. Pressure does nothing for changing opinions. All it does is push people farther in to their own perspective. Curiosity and compassionate inquiry leads to persuasion.

Complexity and the rapid rate of change demands a new kind of leadership - a next level leadership. Next level is about shifting perspective to be an Amplifier - someone focused on impact and not just results. When we expand our perspective we can have greater positive contribution. There are common blocks to this kind of boundless leadership: Limited awareness about the future, trends, and our own internal operating systems - our beliefs. We need to develop this awareness for the core reason that visionaries attract people. Taking culture for granted. Many leaders smugly think their culture is doing great (because they, of course, are leading it). Culture runs companies. It is the operating system for people, and you need to program it well. Procrastination around new technologies. Technology drives change and many leaders hesitate to implement.

I met Colin Ellis a few years ago when he first arrived in Australia from Liverpool. He makes dapper cool again with his sensational dress sense and million dollar smile. He loves the people stuff as much as I do, and in this podcast episode we geek out on all things culture.  Why you should listen: Why culture change IS NOT HARD (like consultants say it is) and takes 9-18 months (not 3-5 years) How to (and how not to) measure culture Where to start in dealing with toxic cultures We explore: The ultimate measure of culture is how happy people are. As the leader, if you are not addressing the behavior, you're part of the problem. ultimately, in toxic cultures, managers have got to look at themselves in the mirror. As a leader, if you're not in service to the people, you're not a leader. You're a manager doing things the way that you want to do them, not the way that the other person wants them to be done. 

Worst Meatball Sandwich Ever, Episode 12 – Casinos, the Jackpot of Crackpots [soundcloud url=”https://api.soundcloud.com/tracks/281283827″ params=”auto_play=false&hide_related=false&show_comments=true&show_user=true&show_reposts=false&visual=true” width=”100%” height=”450″ iframe=”true” /]