Podcasts about paucity

Funding for the NIH and US biomedical research is imperiled at a momentous time of progress. Exemplifying this is the work of Dr. Anna Greka, a leading physician-scientist at the Broad Institute who is devoted to unlocking the mysteries of rare diseases— that cumulatively affect 30 million Americans— and finding cures, science supported by the NIH.A clip from our conversationThe audio is available on iTunes and Spotify. The full video is linked here, at the top, and also can be found on YouTube.Transcript with audio and external linksEric Topol (00:06):Well, hello. This is Eric Topol from Ground Truths, and I am really delighted to welcome today, Anna Greka. Anna is the president of the American Society for Clinical Investigation (ASCI) this year, a very prestigious organization, but she's also at Mass General Brigham, a nephrologist, a cell biologist, a physician-scientist, a Core Institute Member of the Broad Institute of MIT and Harvard, and serves as a member of the institute's Executive Leadership Team. So we got a lot to talk about of all these different things you do. You must be pretty darn unique, Anna, because I don't know any cell biologists, nephrologists, physician-scientist like you.Anna Greka (00:48):Oh, thank you. It's a great honor to be here and glad to chat with you, Eric.Eric Topol (00:54):Yeah. Well, I had the real pleasure to hear you speak at a November conference, the AI for Science Forum, which we'll link to your panel. Where I was in a different panel, but you spoke about your extraordinary work and it became clear that we need to get you on Ground Truths, so you can tell your story to everybody. So I thought rather than kind of going back from the past where you were in Greece and somehow migrated to Boston and all that. We're going to get to that, but you gave an amazing TED Talk and it really encapsulated one of the many phenomenal stories of your work as a molecular sleuth. So maybe if you could give us a synopsis, and of course we'll link to that so people could watch the whole talk. But I think that Mucin-1 or MUC1, as you call it, discovery is really important to kind of ground our discussion.A Mysterious Kidney Disease Unraveled Anna Greka (01:59):Oh, absolutely. Yeah, it's an interesting story. In some ways, in my TED Talk, I highlight one of the important families of this story, a family from Utah, but there's also other important families that are also part of the story. And this is also what I spoke about in London when we were together, and this is really sort of a medical mystery that initially started on the Mediterranean island of Cyprus, where it was found that there were many families in which in every generation, several members suffered and ultimately died from what at the time was a mysterious kidney disease. This was more than 30 years ago, and it was clear that there was something genetic going on, but it was impossible to identify the gene. And then even with the advent of Next-Gen sequencing, this is what's so interesting about this story, it was still hard to find the gene, which is a little surprising.Anna Greka (02:51):After we were able to sequence families and identify monogenic mutations pretty readily, this was still very resistant. And then it actually took the firepower of the Broad Institute, and it's actually from a scientific perspective, an interesting story because they had to dust off the old-fashioned Sanger sequencing in order to get this done. But they were ultimately able to identify this mutation in a VNTR region of the MUC1 gene. The Mucin-1 gene, which I call a dark corner of the human genome, it was really, it's highly repetitive, very GC-rich. So it becomes very difficult to sequence through there with Next-Gen sequencing. And so, ultimately the mutation of course was found and it's a single cytosine insertion in a stretch of cytosines that sort of causes this frameshift mutation and an early stop codon that essentially results in a neoprotein like a toxic, what I call a mangled protein that sort of accumulates inside the kidney cells.Anna Greka (03:55):And that's where my sort of adventure began. It was Eric Lander's group, who is the founding director of the Broad who discovered the mutation. And then through a conversation we had here in Boston, we sort of discovered that there was an opportunity to collaborate and so that's how I came to the Broad, and that's the beginnings of this story. I think what's fascinating about this story though, that starts in a remote Mediterranean island and then turns out to be a disease that you can find in every continent all over the world. There are probably millions of patients with kidney disease in whom we haven't recognized the existence of this mutation. What's really interesting about it though is that what we discovered is that the mangled protein that's a result of this misspelling of this mutation is ultimately captured by a family of cargo receptors, they're called the TMED cargo receptors and they end up sort of grabbing these misfolded proteins and holding onto them so tight that it's impossible for the cell to get rid of them.Anna Greka (04:55):And they become this growing heap of molecular trash, if you will, that becomes really hard to manage, and the cells ultimately die. So in the process of doing this molecular sleuthing, as I call it, we actually also identified a small molecule that actually disrupts these cargo receptors. And as I described in my TED Talk, it's a little bit like having these cargo trucks that ultimately need to go into the lysosome, the cells recycling facility. And this is exactly what this small molecule can do. And so, it was just like a remarkable story of discovery. And then I think the most exciting of all is that these cargo receptors turn out to be not only relevant to this one mangled misshapen protein, but they actually handle a completely different misshapen protein caused by a different genetic mutation in the eye, causing retinitis pigmentosa, a form of blindness, familial blindness. We're now studying familial Alzheimer's disease that's also involving these cargo receptors, and there are other mangled misshapen proteins in the liver, in the lung that we're now studying. So this becomes what I call a node, like a nodal mechanism that can be targeted for the benefit of many more patients than we had previously thought possible, which has been I think, the most satisfying part about this story of molecular sleuthing.Eric Topol (06:20):Yeah, and it's pretty extraordinary. We'll put the figure from your classic Cell paper in 2019, where you have a small molecule that targets the cargo receptor called TMED9.Anna Greka (06:34):Correct.Expanding the MissionEric Topol (06:34):And what's amazing about this, of course, is the potential to reverse this toxic protein disease. And as you say, it may have applicability well beyond this MUC1 kidney story, but rather eye disease with retinitis pigmentosa and the familial Alzheimer's and who knows what else. And what's also fascinating about this is how, as you said, there were these limited number of families with the kidney disease and then you found another one, uromodulin. So there's now, as you say, thousands of families, and that gets me to part of your sleuth work is not just hardcore science. You started an entity called the Ladders to Cures (L2C) Scientific Accelerator.Eric Topol (07:27):Maybe you can tell us about that because this is really pulling together all the forces, which includes the patient advocacy groups, and how are we going to move forward like this?Anna Greka (07:39):Absolutely. I think the goal of the Ladders to Cures Accelerator, which is a new initiative that we started at the Broad, but it really encompasses many colleagues across Boston. And now increasingly it's becoming sort of a national, we even have some international collaborations, and it's only two years that it's been in existence, so we're certainly in a growth mode. But the inspiration was really some of this molecular sleuthing work where I basically thought, well, for starters, it cannot be that there's only one molecular node, these TMED cargo receptors that we discovered there's got to be more, right? And so, there's a need to systematically go and find more nodes because obviously as anyone who works in rare genetic diseases will tell you, the problem for all of us is that we do what I call hand to hand combat. We start with the disease with one mutation, and we try to uncover the mechanism and then try to develop therapies, and that's wonderful.Anna Greka (08:33):But of course, it's slow, right? And if we consider the fact that there are 30 million patients in the United States in every state, everywhere in the country who suffer from a rare genetic disease, most of them, more than half of them are children, then we can appreciate the magnitude of the problem. Out of more than 8,000 genes that are involved in rare genetic diseases, we barely have something that looks like a therapy for maybe 500 of them. So there's a huge mismatch in the unmet need and magnitude of the problem. So the Ladders to Cures Accelerator is here to address this and to do this with the most modern tools available. And to your point, Eric, to bring patients along, not just as the recipients of whatever we discover, but also as partners in the research enterprise because it's really important to bring their perspectives and of course their partnerships in things like developing appropriate biomarkers, for example, for what we do down the road.Anna Greka (09:35):But from a fundamental scientific perspective, this is basically a project that aims to identify every opportunity for nodes, underlying all rare genetic diseases as quickly as possible. And this was one of the reasons I was there at the AI for Science Forum, because of course when one undertakes a project in which you're basically, this is what we're trying to do in the Ladders to Cures Accelerator, introduce dozens of thousands of missense and nonsense human mutations that cause genetic diseases, simultaneously introduce them into multiple human cells and then use modern scalable technology tools. Things like CRISPR screens, massively parallel CRISPR screens to try to interrogate all of these diseases in parallel, identify the nodes, and then develop of course therapeutic programs based on the discovery of these nodes. This is a massive data generation project that is much needed and in addition to the fact that it will help hopefully accelerate our approach to all rare diseases, genetic diseases. It is also a highly controlled cell perturbation dataset that will require the most modern tools in AI, not only to extract the data and understand the data of this dataset, but also because this, again, an extremely controlled, well controlled cell perturbation dataset can be used to train models, train AI models, so that in the future, and I hope this doesn't sound too futuristic, but I think that we're all aiming for that cell biologists for sure dream of this moment, I think when we can actually have in silico the opportunity to make predictions about what cell behaviors are going to look like based on a new perturbation that was not in the training set. So an experiment that hasn't yet been done on a cell, a perturbation that has not been made on a human cell, what if like a new drug, for example, or a new kind of perturbation, a new chemical perturbation, how would it affect the behavior of the cell? Can we make a predictive model for that? This doesn't exist today, but I think this is something, the cell prediction model is a big question for biology for the future. And so, I'm very energized by the opportunity to both address this problem of rare monogenic diseases that remains an unmet need and help as many patients as possible while at the same time advancing biology as much as we possibly can. So it's kind of like a win-win lifting all boats type of enterprise, hopefully.Eric Topol (12:11):Yeah. Well, there's many things to get to unpack what you've just been reviewing. So one thing for sure is that of these 8,000 monogenic diseases, they have relevance to the polygenic common diseases, of course. And then also the fact that the patient family advocates, they are great at scouring the world internet, finding more people, bringing together communities for each of these, as you point out aptly, these rare diseases cumulatively are high, very high proportion, 10% of Americans or more. So they're not so rare when you think about the overall.Anna Greka (12:52):Collectively.Help From the Virtual Cell?Eric Topol (12:53):Yeah. Now, and of course is this toxic proteinopathies, there's at least 50 of these and the point that people have been thinking until now that, oh, we found a mangled protein, but what you've zeroed in on is that, hey, you know what, it's not just a mangled protein, it's how it gets stuck in the cell and that it can't get to the lysosome to get rid of it, there's no waste system. And so, this is such fundamental work. Now that gets me to the virtual cell story, kind of what you're getting into. I just had a conversation with Charlotte Bunne and Steve Quake who published a paper in December on the virtual cell, and of course that's many years off, but of course it's a big, bold, ambitious project to be able to say, as you just summarized, if you had cells in silico and you could do perturbations in silico, and of course they were validated by actual experiments or bidirectionally the experiments, the real ones helped to validate the virtual cell, but then you could get a true acceleration of your understanding of cell biology, your field of course.Anna Greka (14:09):Exactly.Eric Topol (14:12):So what you described, is it the same as a virtual cell? Is it kind of a precursor to it? How do you conceive this because this is such a complex, I mean it's a fundamental unit of life, but it's also so much more complex than a protein or an RNA because not only all the things inside the cell, inside all these organelles and nucleus, but then there's all the outside interactions. So this is a bold challenge, right?Anna Greka (14:41):Oh my god, it's absolutely from a biologist perspective, it's the challenge of a generation for sure. We think taking humans to Mars, I mean that's an aspirational sort of big ambitious goal. I think this is the, if you will, the Mars shot for biology, being able to, whether the terminology, whether you call it a virtual cell. I like the idea of saying that to state it as a problem, the way that people who think about it from a mathematics perspective for example, would think about it. I think stating it as the cell prediction problem appeals to me because it actually forces us biologists to think about setting up the way that we would do these cell perturbation data sets, the way we would generate them to set them up to serve predictions. So for example, the way that I would think about this would be can I in the future have so much information about how cell perturbations work that I can train a model so that it can predict when I show it a picture of another cell under different conditions that it hasn't seen before, that it can still tell me, ah, this is a neuron in which you perturbed the mitochondria, for example, and now this is sort of the outcome that you would expect to see.Anna Greka (16:08):And so, to be able to have this ability to have a model that can have the ability to predict in silico what cells would look like after perturbation, I think that's sort of the way that I think about this problem. It is very far away from anything that exists today. But I think that the beginning starts, and this is one of the unique things about my institute, if I can say, we have a place where cell biologists, geneticists, mathematicians, machine learning experts, we all come together in the same place to really think and grapple with these problems. And of course we're very outward facing, interacting with scientists all across the world as well. But there's this sort of idea of bringing people into one institute where we can just think creatively about these big aspirational problems that we want to solve. I think this is one of the unique things about the ecosystem at the Broad Institute, which I'm proud to be a part of, and it is this kind of out of the box thinking that will hopefully get us to generate the kinds of data sets that will serve the needs of building these kinds of models with predictive capabilities down the road.Anna Greka (17:19):But as you astutely said, AlphaFold of course was based on the protein database existing, right? And that was a wealth of available information in which one could train models that would ultimately be predictive, as we have seen this miracle that Demi Hassabis and John Jumper have given to humanity, if you will.Anna Greka (17:42):But as Demis and John would also say, I believe is as I have discussed with them, in fact, the cell prediction problem is really a bigger problem because we do not have a protein data bank to go to right now, but we need to create it to generate these data. And so, my Ladders to Cures Accelerator is here to basically provide some part of the answer to that problem, create this kind of well-controlled database that we need for cell perturbations, while at the same time maximizing our learnings about these fully penetrant coding mutations and what their downstream sequelae would be in many different human cells. And so, in this way, I think we can both advance our knowledge about these monogenic diseases, build models, hopefully with predictive capabilities. And to your point, a lot of what we will learn about this biology, if we think that it involves 8,000 or more out of the 20,000 genes in our genome, it will of course serve our understanding of polygenic diseases ultimately as well as we go deeper into this biology and we look at the combinatorial aspects of what different mutations do to human cells. And so, it's a huge aspirational problem for a whole generation, but it's a good one to work on, I would say.Learning the Language of Life with A.I. Eric Topol (19:01):Oh, absolutely. Now I think you already mentioned something that's quite, well, two things from what you just touched on. One of course, how vital it is to have this inner or transdisciplinary capability because you do need expertise across these vital areas. But the convergence, I mean, I love your term nodal biology and the fact that there's all these diseases like you were talking about, they do converge and nodal is a good term to highlight that, but it's not. Of course, as you mentioned, we have genome editing which allows to look at lots of different genome perturbations, like the single letter change that you found in MUC1 pathogenic critical mutation. There's also the AI world which is blossoming like I've never seen. In fact, I had in Science this week about learning the language of life with AI and how there's been like 15 new foundation models, DNA, proteins, RNA, ligands, all their interactions and the beginning of the cell story too with the human cell.Eric Topol (20:14):So this is exploding. As you said, the expertise in computer science and then this whole idea that you could take these powerful tools and do as you said, which is the need to accelerate, we just can't sit around here when there's so much discovery work to be done with the scalability, even though it might take years to get to this artificial intelligence virtual cell, which I have to agree, everyone in biology would say that's the holy grail. And as you remember at our conference in London, Demi Hassabis said that's what we'd like to do now. So it has the attention of leaders in AI around the world, obviously in the science and the biomedical community like you and many others. So it is an extraordinary time where we just can't sit still with these tools that we have, right?Anna Greka (21:15):Absolutely. And I think this is going to be, you mentioned the ASCI presidency in the beginning of our call. This is going to be the president gets to give an address at the annual meeting in Chicago. This is going to be one of the points I make, no matter what field in biomedicine we're in, we live in, I believe, a golden era and we have so many tools available to us that we can really accelerate our ability to help more patients. And of course, this is our mandate, the most important stakeholders for everything that we do as physician-scientists are our patients ultimately. So I feel very hopeful for the future and our ability to use these tools and to really make good on the promise of research is a public good. And I really hope that we can advance our knowledge for the benefit of all. And this is really an exciting time, I think, to be in this field and hopefully for the younger colleagues a time to really get excited about getting in there and getting involved and asking the big questions.Career ReflectionsEric Topol (22:21):Well, you are the prototype for this and an inspiration to everyone really, I'm sure to your lab group, which you highlighted in the TED Talk and many other things that you do. Now I want to spend a little bit of time about your career. I think it's fascinating that you grew up in Greece and your father's a nephrologist and your mother's a pathologist. So you had two physicians to model, but I guess you decided to go after nephrology, which is an area in medicine that I kind of liken it to Rodney Dangerfield, he doesn't get any respect. You don't see many people that go into nephrology. But before we get to your decision to do that somehow or other you came from Greece to Harvard for your undergrad. How did you make that connect to start your college education? And then subsequently you of course you stayed in Boston, you've never left Boston, I think.Anna Greka (23:24):I never left. Yeah, this is coming into 31 years now in Boston.Anna Greka (23:29):Yeah, I started as a Harvard undergraduate and I'm now a full professor. It's kind of a long, but wonderful road. Well, actually I would credit my parents. You mentioned that my father, they're both physician-scientists. My father is now both retired, but my father is a nephrologist, and my mother is a pathologist, actually, they were both academics. And so, when we were very young, we lived in England when my parents were doing postdoctoral work. That was actually a wonderful gift that they gave me because I became bilingual. It was a very young age, and so that allowed me to have this advantage of being fluent in English. And then when we moved back to Greece where I grew up, I went to an American school. And from that time, this is actually an interesting story in itself. I'm very proud of this school.Anna Greka (24:22):It's called Anatolia, and it was founded by American missionaries from Williams College a long time ago, 150 and more years ago. But it is in Thessaloniki, Greece, which is my hometown, and it's a wonderful institution, which gave me a lot of gifts as well, preparing me for coming to college in the United States. And of course, I was a good student in high school, but what really was catalytic was that I was lucky enough to get a scholarship to go to Harvard. And that was really, you could say the catalyst that propelled me from a teenager who was dreaming about a career as a physician-scientist because I certainly was for as far back as I remember in fact. But then to make that a reality, I found myself on the Harvard campus initially for college, and then I was in the combined Harvard-MIT program for my MD PhD. And then I trained in Boston at Mass General in Brigham, and then sort of started my academic career. And that sort of brings us to today, but it is an unlikely story and one that I feel still very lucky and blessed to have had these opportunities. So for sure, it's been wonderful.Eric Topol (25:35):We're the ones lucky that you came here and set up shop and you did your productivity and discovery work and sleuthing has been incredible. But I do think it's interesting too, because when you did your PhD, it was in neuroscience.Anna Greka (25:52):Ah, yes. That's another.Eric Topol (25:54):And then you switch gears. So tell us about that?Anna Greka (25:57):This is interesting, and actually I encourage more colleagues to think about it this way. So I have always been driven by the science, and I think that it seems a little backward to some people, but I did my PhD in neuroscience because I was interested in understanding something about these ion channels that were newly discovered at the time, and they were most highly expressed in the brain. So here I was doing work in the brain in the neuroscience program at Harvard, but then once I completed my PhD and I was in the middle of my residency training actually at Mass General, I distinctly remember that there was a paper that came out that implicated the same family of ion channels that I had spent my time understanding in the brain. It turned out to be a channelopathy that causes kidney disease.Anna Greka (26:43):So that was the light bulb, and it made me realize that maybe what I really wanted to do is just follow this thread. And my scientific curiosity basically led me into studying the kidney and then it seemed practical therefore to get done with my clinical training as efficiently as possible. So I finished residency, I did nephrology training, and then there I was in the lab trying to understand the biology around this channelopathy. And that sort of led us into the early projects in my young lab. And in fact, it's interesting we didn't talk about that work, but that work in itself actually has made it all the way to phase II trials in patients. This was a paper we published in Science in 2017 and follow onto that work, there was an opportunity to build this into a real drug targeting one of these ion channels that has made it into phase II trials. And we'll see what happens next. But it's this idea of following your scientific curiosity, which I also talked about in my TED Talk, because you don't know to what wonderful places it will lead you. And quite interestingly now my lab is back into studying familial Alzheimer's and retinitis pigmentosa in the eye in brain. So I tell people, do not limit yourself to whatever someone says your field is or should be. Just follow your scientific curiosity and usually that takes you to a lot more interesting places. And so, that's certainly been a theme from my career, I would say.Eric Topol (28:14):No, I think that's perfect. Curiosity driven science is not the term. You often hear hypothesis driven or now with AI you hear more AI exploratory science. But no, that's great. Now I want to get a little back to the AI story because it's so fascinating. You use lots of different types of AI such as cellular imaging would be fusion models and drug discovery. I mean, you've had drug discovery for different pathways. You mentioned of course the ion channel and then also as we touched on with your Cell paper, the whole idea of targeting the cargo receptor with a small molecule and then things in between. You discussed this of course at the London panel, but maybe you just give us the skinny on the different ways that you incorporate AI in the state-of-the-art science that you're doing?Anna Greka (29:17):Sure, yeah, thank you. I think there are many ways in which even for quite a long time before AI became such a well-known kind of household term, if you will, the concept of machine learning in terms of image processing is something that has been around for some time. And so, this is actually a form of AI that we use in order to process millions of images. My lab has by produced probably more than 20 million images over the last few years, maybe five to six years. And so, if you can imagine it's impossible for any human to process this many images and make sense of them. So of course, we've been using machine learning that is becoming increasingly more and more sophisticated and advanced in terms of being able to do analysis of images, which is a lot of what we cell biologists do, of course.Anna Greka (30:06):And so, there's multiple different kinds of perturbations that we do to cells, whether we're using CRISPR or base editing to make, for example, genome wide or genome scale perturbations or small molecules as we have done as well in the past. These are all ways in which we are then using machine learning to read out the effects in images of cells that we're looking at. So that's one way in which machine learning is used in our daily work, of course, because we study misshape and mangled proteins and how they are recognized by these cargo receptors. We also use AlphaFold pretty much every day in my lab. And this has been catalytic for us as a tool because we really are able to accelerate our discoveries in ways that were even just three or four years ago, completely impossible. So it's been incredible to see how the young people in my lab are just so excited to use these tools and they're becoming extremely savvy in using these tools.Anna Greka (31:06):Of course, this is a new generation of scientists, and so we use AlphaFold all the time. And this also has a lot of implications of course for some of the interventions that we might think about. So where in this cargo receptor complex that we study for example, might we be able to fit a drug that would disrupt the complex and lead the cargo tracks into the lysosome for degradation, for example. So there's many ways in which AI can be used for all of these functions. So I would say that if we were to organize our thinking around it, one way to think about the use of machine learning AI is around what I would call understanding biology in cells and what in sort of more kind of drug discovery terms you would call target identification, trying to understand the things that we might want to intervene on in order to have a benefit for disease.Anna Greka (31:59):So target ID is one area in which I think machine learning and AI will have a catalytic effect as they already are. The other of course, is in the actual development of the appropriate drugs in a rational way. So rational drug design is incredibly enabled by AlphaFold and all these advances in terms of understanding protein structures and how to fit drugs into them of all different modalities and kinds. And I think an area that we are not yet harnessing in my group, but I think the Ladders to Cures Accelerator hopes to build on is really patient data. I think that there's a lot of opportunity for AI to be used to make sense of medical records for example and how we extract information that would tell us that this cohort of patients is a better cohort to enroll in your trial versus another. There are many ways in which we can make use of these tools. Not all of them are there yet, but I think it's an exciting time for being involved in this kind of work.Eric Topol (32:58):Oh, no question. Now it must be tough when you know the mechanism of these families disease and you even have a drug candidate, but that it takes so long to go from that to helping these families. And what are your thoughts about that, I mean, are you thinking also about genome editing for some of these diseases or are you thinking to go through the route of here's a small molecule, here's the tox data in animal models and here's phase I and on and on. Where do you think because when you know so much and then these people are suffering, how do you bridge that gap?Anna Greka (33:39):Yeah, I think that's an excellent question. Of course, having patients as our partners in our research is incredible as a way for us to understand the disease, to build biomarkers, but it is also exactly creating this kind of emotional conflict, if you will, because of course, to me, honesty is the best policy, if you will. And so, I'm always very honest with patients and their families. I welcome them to the lab so they can see just how long it takes to get some of these things done. Even today with all the tools that we have, of course there are certain things that are still quite slow to do. And even if you have a perfect drug that looks like it fits into the right pocket, there may still be some toxicity, there may be other setbacks. And so, I try to be very honest with patients about the road that we're on. The small molecule path for the toxic proteinopathies is on its way now.Anna Greka (34:34):It's partnered with a pharmaceutical company, so it's on its way hopefully to patients. Of course, again, this is an unpredictable road. Things can happen as you very well know, but I'm at least glad that it's sort of making its way there. But to your point, and I'm in an institute where CRISPR was discovered, and base editing and prime editing were discovered by my colleagues here. So we are in fact looking at every other modality that could help with these diseases. We have several hurdles to overcome because in contrast to the liver and the brain, the kidney for example, is not an organ in which you can easily deliver nucleic acid therapies, but we're making progress. I have a whole subgroup within the bigger group who's focusing on this. It's actually organized in a way where they're running kind of independently from the cell biology group that I run.Anna Greka (35:31):And it's headed by a person who came from industry so that she has the opportunity to really drive the project the way that it would be run milestone driven, if you will, in a way that it would be run as a therapeutics program. And we're really trying to go after all kinds of different nucleic acid therapies that would target the mutations themselves rather than the cargo receptors. And so, there's ASO and siRNA technologies and then also actual gene editing technologies that we are investigating. But I would say that some of them are closer than others. And again, to your question about patients, I tell them honestly when a project looks to be more promising, and I also tell them when a project looks to have hurdles and that it will take long and that sometimes I just don't know how long it will take before we can get there. The only thing that I can promise patients in any of our projects, whether it's Alzheimer's, blindness, kidney disease, all I can promise is that we're working the hardest we possibly can on the problem.Anna Greka (36:34):And I think that is often reassuring I have found to patients, and it's best to be honest about the fact that these things take a long time, but I do think that they find it reassuring that someone is on it essentially, and that there will be some progress as we move forward. And we've made progress in the very first discovery that came out of my lab. As I mentioned to you, we've made it all the way to phase II trials. So I have seen the trajectory be realized, and I'm eager to make it happen again and again as many times as I can within my career to help as many people as possible.The Paucity of Physician-ScientistsEric Topol (37:13):I have no doubts that you'll be doing this many times in your career. No, there's no question about it. It's extraordinary actually. There's a couple of things there I want to pick up on. Physician-scientists, as you know, are a rarefied species. And you have actually so nicely told the story about when you have a physician-scientist, you're caring for the patients that you're researching, which is, most of the time we have scientists. Nothing wrong with them of course, but you have this hinge point, which is really important because you're really hearing the stories and experiencing the patients and as you say, communicating about the likelihood of being able to come up with a treatment or the progress. What are we going to do to get more physician-scientists? Because this is a huge problem, it has been for decades, but the numbers just keep going lower and lower.Anna Greka (38:15):I think you're absolutely right. And this is again, something that in my leadership of the ASCI I have made sort of a cornerstone of our efforts. I think that it has been well-documented as a problem. I think that the pressures of modern clinical care are really antithetical to the needs of research, protected time to really be able to think and be creative and even have the funding available to be able to pursue one's program. I think those pressures are becoming so heavy for investigators that many of them kind of choose one or the other route most often the clinical route because that tends to be, of course where they can support their families better. And so, this has been kind of the conundrum in some ways that we take our best and brightest medical students who are interested in investigation, we train them and invest in them in becoming physician-scientists, but then we sort of drop them at the most vulnerable time, which is usually after one completes their clinical and scientific training.Anna Greka (39:24):And they're embarking on early phases of one's careers. It has been found to be a very vulnerable point when a lot of people are now in their mid-thirties or even late thirties perhaps with some family to take care of other burdens of adulthood, if you will. And I think what it becomes very difficult to sustain a career where one salary is very limited due to the research component. And so, I think we have to invest in our youngest people, and it is a real issue that there's no good mechanism to do that at the present time. So I was actually really hoping that there would be an opportunity with leadership at the NIH to really think about this. It's also been discussed at the level of the National Academy of Medicine where I had some role in discussing the recent report that they put out on the biomedical enterprise in the United States. And it's kind of interesting to see that there is a note made there about this issue and the fact that there needs to be, I think, more generous investment in the careers of a few select physician-scientists that we can support. So if you look at the numbers, currently out of the entire physician workforce, a physician-scientist comprised of less than 1%.Anna Greka (40:45):It's probably closer to 0.8% at this point.Eric Topol (40:46):No, it's incredible.Anna Greka (40:48):So that's really not enough, I think, to maintain the enterprise and if you will, this incredible innovation economy that the United States has had this miracle engine, if you will, in biomedicine that has been fueled in large part by physician investigators. Of course, our colleagues who are non-physician investigators are equally important partners in this journey. But we do need a few of the physician-scientists investigators I think as well, if you really think about the fact that I think 70% of people who run R&D programs in all the big pharmaceutical companies are physician-scientists. And so, we need people like us to be able to work on these big problems. And so, more investment, I think that the government, the NIH has a role to play there of course. And this is important from both an economic perspective, a competition perspective with other nations around the world who are actually heavily investing in the physician-scientist workforce.Anna Greka (41:51):And I think it's also important to do so through our smaller scale efforts at the ASCI. So one of the things that I have been involved in as a council member and now as president is the creation of an awards program for those early career investigators. So we call them the Emerging-Generation Awards, and we also have the Young Physician-Scientist Awards. And these are really to recognize people who are making that transition from being kind of a trainee and a postdoc and have finished their clinical training into becoming an independent assistant professor. And so, those are small awards, but they're kind of a symbolic tap on the shoulder, if you will, that the ASCI sees you, you're talented, stay the course. We want you to become a future member. Don't give up and please keep on fighting. I think that can take us only so far.Anna Greka (42:45):I mean, unless there's a real investment, of course still it will be hard to maintain people in the pipeline. But this is just one way in which we have tried to, these programs that the ASCI offers have been very successful over the last few years. We create a cohort of investigators who are clearly recognized by members of the ASCI is being promising young colleagues. And we give them longitudinal training as part of a cohort where they learn about how to write a grant, how to write a paper, leadership skills, how to run a lab. And they're sort of like a buddy system as well. So they know that they're in it together rather than feeling isolated and struggling to get their careers going. And so, we've seen a lot of success. One way that we measure that is conversion into an ASCI membership. And so, we're encouraged by that, and we hope that the program can continue. And of course, as president, I'm going to be fundraising for that as well, it's part of the role. But it is a really worthy cause because to your point, we have to somehow make sure that our younger colleagues stay the course that we can at least maintain, if not bolster our numbers within the scientific workforce.Eric Topol (43:57):Well, you outlined some really nice strategies and plans. It's a formidable challenge, of course. And we'd like to see billions of dollars to support this. And maybe someday we will because as you say, if we could relieve the financial concerns of people who have curiosity driven ideas.Anna Greka (44:18):Exactly.Eric Topol (44:19):We could do a lot to replenish and build a big physician-scientist workforce. Now, the last thing I want to get to, is you have great communication skills. Obviously, anybody who is listening or watching this.Eric Topol (44:36):Which is another really important part of being a scientist, no less a physician or the hybrid of the two. But I wanted to just go to the backstory because your TED Talk, which has been watched by hundreds of thousands of people, and I'm sure there's hundreds of thousands more that will watch it, but the TED organization is famous for making people come to the place a week ahead. This is Vancouver used to be in LA or Los Angeles area and making them rehearse the talk, rehearse, rehearse, rehearse, which seems crazy. You could train the people there, how to give a talk. Did you have to go through that?Anna Greka (45:21):Not really. I did rehearse once on stage before I actually delivered the talk live. And I was very encouraged by the fact that the TED folks who are of course very well calibrated, said just like that. It's great, just like that.Eric Topol (45:37):That says a lot because a lot of people that do these talks, they have to do it 10 times. So that kind of was another metric. But what I don't like about that is it just because these people almost have to memorize their talks from giving it so much and all this coaching, it comes across kind of stilted and unnatural, and you're just a natural great communicator added to all your other things.Anna Greka (46:03):I think it's interesting. Actually, I would say, if I may, that I credit, of course, I actually think that it's important, for us physician-scientists, again, science and research is a public good, and being able to communicate to the public what it is that we do, I think is kind of an obligation for the fact that we are funded by the public to do this kind of work. And so, I think that's important. And I always wanted to cultivate those communication skills for the benefit of communicating simply and clearly what it is that we do in our labs. But also, I would say as part of my story, I mentioned that I had the opportunity to attend a special school growing up in Greece, Anatolia, which was an American school. One of the interesting things about that is that there was an oratory competition.Anna Greka (46:50):I got very early exposure entering that competition. And if you won the first prize, it was in the kind of ancient Rome way, first among equals, right? And so, that was the prize. And I was lucky to have this early exposure. This is when I was 14, 15, 16 years old, that I was training to give these oratory speeches in front of an audience and sort of compete with other kids who were doing the same. I think these are just wonderful gifts that a school can give a student that have stayed with me for life. And I think that that's a wonderful, yeah, I credit that experience for a lot of my subsequent capabilities in this area.Eric Topol (47:40):Oh, that's fantastic. Well, this has been such an enjoyable conversation, Anna. Did I miss anything that we need to bring up, or do you think we have it covered?Anna Greka (47:50):Not at all. No, this was wonderful, and I thoroughly enjoyed it as well. I'm very honored seeing how many other incredible colleagues you've had on the show. It's just a great honor to be a part of this. So thank you for having me.Eric Topol (48:05):Well, you really are such a great inspiration to all of us in the biomedical community, and we'll be cheering for your continued success and thanks so much for joining today, and I look forward to the next time we get a chance to visit.Anna Greka (48:20):Absolutely. Thank you, Eric.**************************************Thanks for listening, watching or reading Ground Truths. Your subscription is greatly appreciated.If you found this podcast interesting please share it!That makes the work involved in putting these together especially worthwhile.All content on Ground Truths—newsletters, analyses, and podcasts—is free, open-access.Paid subscriptions are voluntary and all proceeds from them go to support Scripps Research. They do allow for posting comments and questions, which I do my best to respond to. Many thanks to those who have contributed—they have greatly helped fund our summer internship programs for the past two years. And such support is becoming more vital In light of current changes of funding and support for biomedical research at NIH and other US governmental agencies.Thanks to my producer Jessica Nguyen and to Sinjun Balabanoff for audio and video support at Scripps Research. Get full access to Ground Truths at erictopol.substack.com/subscribe

Who is to blame for the lack of behavioral medicine in our veterinary education system? Certainly NOT the Amys! In this episode, the Amys tackle the state of veterinary behavior medicine education in North America with their colleague, Dr. Chris Pachel, DACVB. Dr. Chris educates veterinary students and veterinarians around the globe on behavior medicine, so why is there still such bad advice coming out of the mouths of our veterinarian friends and colleagues? What are we to do about that? Can trainers and clients even trust what their vet says about behavior?Take a listen and learn more with Amy, Gwendolyn

This is The Briefing, a daily analysis of news and events from a Christian worldview.Part I (00:13 - 04:19)Abortion and the Tale of Two States: Florida's 6-Week Abortion Ban Takes Effect As Arizona Repeals 1864 Abortion BanPart II (04:19 - 10:58)Communist Cuba Flirts with Capitalism? Free Market, Human Flourishing, and the Failures of CommunismIn a Communist Stronghold, Capitalists Become an Economic Lifeline by The New York Times (David C. Adams)Part III (10:58 - 16:10)Why the Paucity of Evangelicals on the Supreme Court? — Dr. Mohler Responds to Letters from Listeners of The BriefingPart IV (16:10 - 22:20)Do Roman Catholics Go to Heaven? — Dr. Mohler Responds to Letters from Listeners of The BriefingPart V (22:20 - 26:02)Is the Bible Both Inerrant and Infallible? — Dr. Mohler Responds to Letters from Listeners of The BriefingPart VI (26:02 - 28:58)Is the Position of the Pope Analogous in Any Way to the President to the SBC? — Dr. Mohler Responds to Letters from Listeners of The BriefingThe Chicago Statement on Biblical Inerrancy by Sign up to receive The Briefing in your inbox every weekday morning.Follow Dr. Mohler:X | Instagram | Facebook | YouTubeFor more information on The Southern Baptist Theological Seminary, go to sbts.edu.For more information on Boyce College, just go to BoyceCollege.com.To write Dr. Mohler or submit a question for The Mailbox, go here.

Word Test for the following Episodes and Words. 111: Articulate, Dilate, Refute, Dogma 112: Impervious, Impassive, Enumerate, Effrontery  113: Conventional, Fatuous, Repose, Malleable 114: Repast, Desultory, Languid, Exponent 115: Volatile, Affected, Qualified, Effigy 116: Sedition, Intransigence, Indeterminate, Fortuitous 117: Jocular, Idolatry, Vex, Glower 118: Diffuse, Disparage, Magnate, Solipsism 119: Insinuate, Sycophant, Jingoism, Paucity 120: Mollify, Mercurial, Compendium, Discordant VictorPrep's vocab podcast is for improving for English vocabulary skills while helping you prepare for your standardized tests! This podcast isn't only intended for those studying for the GRE or SAT, but also for people who enjoy learning, and especially those who want to improve their English skills. I run the podcast for fun and because I want to help people out there studying for tests or simply learning English. The podcast covers a variety of words and sometimes additionally covers word roots. Using a podcast to prep for the verbal test lets you study while on the go, or even while working out!  If you have comments or questions and suggestions, please send me an email at sam.fold@gmail.com

The words for today are: Insinuate, Sycophant, Jingoism, Paucity Featuring a quote from Marcus Aurelius: "Meditations" VictorPrep's vocab podcast is for improving for English vocabulary skills while helping you prepare for your standardized tests! This podcast isn't only intended for those studying for the GRE or SAT, but also for people who enjoy learning, and especially those who want to improve their English skills. I run the podcast for fun and because I want to help people out there studying for tests or simply learning English. The podcast covers a variety of words and sometimes additionally covers word roots. Using a podcast to prep for the verbal test lets you study while on the go, or even while working out!  If you have comments or questions and suggestions, please send me an email at sam.fold@gmail.com

Link to bioRxiv paper: http://biorxiv.org/cgi/content/short/2023.07.27.550884v1?rss=1 Authors: Jury-Garfe, N., You, Y., Martinez, P., Redding-Ochoa, J., Karahan, H., Johnson, T. S., Zhang, J., Kim, J., Troncoso, J. C., Lasagna-Reeves, C. A. Abstract: Asymptomatic Alzheimer 's disease (AsymAD) describes the status of subjects with preserved cognition but with identifiable Alzheimer 's disease (AD) brain pathology (i.e. A {beta}-amyloid deposits, neuritic plaques, and neurofibrillary tangles) at autopsy. In this study, we investigated the postmortem brains of a cohort of AsymAD cases to gain insight into the underlying mechanisms of resilience to AD pathology and cognitive decline. Our results showed that AsymAD cases exhibit an enrichment of core plaques and decreased filamentous plaque accumulation, as well as an increase in microglia surrounding this last type. In AsymAD cases we found less pathological tau aggregation in dystrophic neurites compared to AD and tau seeding activity comparable to healthy control subjects. We used spatial transcriptomics to further characterize the plaque niche and found autophagy, endocytosis, and phagocytosis within the top upregulated pathways in the AsymAD plaque niche, but not in AD. Furthermore, we found ARP2, an actin-based motility protein crucial to initiate the formation of new actin filaments, increased within microglia in the proximity of amyloid plaques in AsymAD. Our findings support that the amyloid-plaque microenvironment in AsymAD cases is characterized by microglia with highly efficient actin-based cell motility mechanisms and decreased tau seeding compared to AD. These two mechanisms can potentially provide protection against the toxic cascade initiated by A {beta} that preserves brain health and slows down the progression of AD pathology. Copy rights belong to original authors. Visit the link for more info Podcast created by Paper Player, LLC

Pancholi was booked for abetment to suicide after actor was found hanging in her home in 2013. Earlier this year, CBI was directed to expedite trial. Prosecution examined 22 witnesses.

A Dose of Dave is a series of bite sized podcasts featuring me on my own. I'm just trying it out to see where it takes me. They're only about 5 mins long. If you wish to contribute to the podcast you can here: - https://www.patreon.com/bullshitdetective

Introduction: Ruth McCarthy is an extreme listener and thought provoker. She is faculty at Time to Think, is a Time to Think Coach & Facilitator. Ruth's business is called Think it Through and she operates from London. Formerly a Student from Trinity College Dublin where she studied Modern Languages. She has a Master's degree in Critical Thinking and Cultural Studies from Birkbeck, University London and of course several Licenses and Certificates from Time to Think LTD.    Podcast Episode Summary This episode explores the conditions necessary for generative thinking. 10 principles housed in the Thinking Environment are brought to life across this episode. Ruth shares the material developed by Nancy Kline, work introduced to the world by her books, Time to Think in 1999, More Time to think in 2009 and just lately the book, The Promise that changes everything as well as the many course offerings and bespoke trainings provided by the company Time To Think LTD where Ruth is a Global Faculty Member.     Points made over the episode Ruth shared how she believes she has lived her life backwards. Somehow in her late 50's Ruth discovered the work of Nancy Kline and was struck by the provocative nature of what she was discovering about how we as humans think She essentially created a career at a later stage in life on material new to her.  Earlier Ruth had a career in book publishing.  Ruth shares the conditions that create a thinking environment.  Place- Producing a physical environment-the room, the listener, your body, that says you matter Attention-Listening without interruption and with interest in where the person will go next in their thinking  Equality-Regarding each other as thinking peers; giving each and equal time to think  Ease-Noticing and discarding internal rush  Appreciation-Noticing what is good and saying it Encouragement-Giving courage to go to the unexplored edge of our thinking by ceasing competition as thinkers  Feelings-Welcoming the release of emotions  Incisive Questions-Freeing the human mind of an untrue assumption lived as true  Information-Absorbing the facts, data, denial, social context Difference-Championing our inherent diversity of identity and thought The thinking environment is a beautiful paradox. Its seeming simplicity is the other side of complexity  It is as simple as saying I will listen to you and I promise not to interrupt you.  I promise to be fascinated by the fact you are thinking rather than focusing on your content and employing my meaning making. It is a promise that says I will not derail your thinking by providing you with exquisite attention  In the presence of this benign generative force (you the listener) the brain of the other can wire and fire The conditions that support a generative thinking environment are available and yet often unpractised. In fact the presence of a thinking environment is often exceptional  To experience the ease that says I will not interrupt you calms your internal system and allows you to think freely. Encouraging the thinker, made implicit by attention, allows the thinker to go far and wide with their thinking.  Encouragement means shutting down competition between members of the team It says you are in a place that matters.  Appreciation is a great unsung hero. We are often taught to be cynical of appreciation and yet it is a hard psychological reality that if we are told what is good about us it creates the neuro chemistry for good thinking  Information and disinformation. We are in an age of mis-information. To think well we need to be presented with the facts, to be able to absorb the data, which is why rounds on teams gives the team an opportunity to hear all the available data Hierarchy and inequality can be a tipping point for teams. Ruth often asks how it would be for a team if it shared the time equally.  Resistance often comes in the form of assumptions. It is the work of a Time to Think facilitator to surface assumptions  Urgency destroys good thinking. Ruth often acts as an agent for ease knowing that in the presence of ease thinking is allowed. We are habituated to compete, to collapse into urgency and reactive ways of being. Interruption and competition are time wasters  Funny that we will pay a professional to show us how to play a sport better and we know we will have to go through the process of feeling uncomfortable holding a new grip for example. The same is true in learning new on Teams.  Trust is an outcome. We need a consistent and recognised way of being with each other to engender Trust. Ruth shares an example of using the 10 components to begin to manifest trust  Paucity of appreciation on teams. The world is rife with ridicule and stuff that we call banter that only supports to contract another. It is important to notice what is good in another and to say it. Appreciation works. There is enough research and evidence to support its efficacy. Consider the Gottman Institute and Heart-math from California.  In order to hear what is difficult the brain needs to hear first what is good. There is a precise proportionality for that and it is 5:1. What works best is to hear a quality, one or two words reflected back to another that ring true. It needs to be a quality rather than a product. This distinction is profound  The Brain is programmed to avoid pain and it will avoid. Emotions like fear, anger, disgust, shame help us to move away. Emotions like joy, love and Trust, emotions that give meaning to life support us to move towards.  You have got to give people the confidence to do their own thinking to get great results.  Nancy Kline is a brilliant and humble leader who models the idea that we can never be sure of being right. Being anti-fragile has got to be a top skill for Leaders today Consider 2 minutes of uninterrupted thinking and how far the brain can go in that time. The average standard is 9 seconds before we are interrupted. Interruption is akin to an attack, a violent act. Unless we have a contract for difference we will no doubt perpetuate a vicious cycle which only means a re-hashing of old thinking  It is worth noting it is kind to practice a Time to Think environment but it is comforting to know that it is also a rigorous practice.  Ruth explores a case where a client of hers employed a Thinking Environment and continues to employ the practices today. She shares how the brain behaves differently in the presence of a question as opposed to a topic.  Nancy Kline's new book, The Promise that Changes Everything discusses in even more detail the 10 conditions and includes topics like polarisation, denial, digitisation and “conformconomics”.  Curiously now that we have moved to a blended form of work where much is conducted online, Ruth believes that two dimensional way of communicating is enhanced by employing the principles of a thinking environment.    Resources shared  Nancy Kline: The Promise That Changes Everything: I won't interrupt you Nancy Kline: More Time to Think: The power of independent thinking  Nancy Kline: Time to Think: Listening to Ignite the Human Mind  www.timetothink.com  www.gottman.com www.heartmath.org 

Alagille syndrome is a genetic disorder that can affect a variety of organs. In the liver it causes a lack of bile ducts to drain bile out of the liver and hence the bile builds up and causes liver damage. It can also affect other parts of the body like the heart, eyes, bones and kidneys. Follow us on Instagram @yourekiddingrightdoctors Our email is yourekiddingrightpod@gmail.com (This isn't individual medical advice, please use your own clinical judgement and local guidelines when caring for your patients)

Merriam-Webster's Word of the Day for December 23, 2021 is: paucity • PAW-suh-tee • noun Paucity implies smallness of number or quantity. // There was a paucity of detail in the report.   See the entry > Examples: "... sparse transit service and a paucity of bicycle lanes often leave automobiles as the only, not necessarily the preferred, transportation option." — David Zipper, The Daily Herald (Everett, Washington), 25 Oct. 2021 Did you know? Paucity refers to "littleness" in numbers (as in "a paucity of facts") or quantity ("a paucity of common sense"). The word comes from paucus, Latin for "little."

Bad news: Sony isn't going to be able to make as many PlayStation 5 consoles as it was hoping, at least in the short term. What does that mean for you? It means that, if you're still on the hunt for a console, you may want to get used to the idea of ponying up for a black market unit or settle in for a long and painful winter. We discuss. Plus: Gaming engine Unity has made a substantial acquisition, Q-Games acquires The Tomorrow Children from Sony, licensing issues bog down GTA's re-releases and Metal Gear Solid's legacy titles alike, Konami has totally botched the rollout of eFootball, and so on, and so on, and so on. Listener inquiries allow us to cleanly wrap things up as always, touching on subjects like Mass Effect's revival, the demise of Jump Force, the uncertain future of Media Molecule, and word from a funeral director that -- yes -- she listens to Sacred Symbols while embalming bodies. We suppose somebody's gotta do it. Learn more about your ad choices. Visit megaphone.fm/adchoices

Word# Back friend Part Of Speech — Noun. * Pronunciation — * Back as usual, back, * friend as usual, friend. * Meaning — * A fake friend or a secret enemy. * Sentences— * If a friend stabs in the back (betrays you), he or she is a backfriend. * Destiny helped him identify his backfriends. (Noun, fake friends or secret enemies) * Having paucity of friends is much better than having plenty of backfriends. (Noun, fake friends or secret enemies) * The backfriend who had used a flimflam to cheat her is now being punished by misfortune. (Noun, a fake friend or a secret enemy) * It requires wisdom and common sense to identify a backfriend. (Noun, a fake friend or a secret enemy) * Synonyms — fake friend, secret enemy, etc. * Antonyms — true friend, etc. * Quick revision of previously learnt words — * Paucity — lack. * Plenteous — lot. * Mendacity — fraud. * Flimflam — trick used to cheat others OR to cheat others. * Idom#conk out * Meaning — * To stop working (referring to a machine) OR * To fall asleep. * Sentences — * I had conked out when my mother was feeding the birds in my balcony. (Fallen asleep) * Feathered friends — birds. * The car conked out; he foolishly neglects it and doesn't give the time of day to it. (Stopped working) * Not give the time of day — refuse to pay the slightest attention. * The little boy seems lost in thought; he will conk out soon. (Fall asleep) * Lost in thought — engrossed in thinking. Phrasal verb #Bear up * Meaning — * Support OR * To be hopeful. * Sentences — * The doctor advised the patient to bear up a little longer. (Be hopeful) * She bears up her friends in their troubles. (Supports) * She still bears up in spite of her struggles. (Is hopeful) * In his misfortune, his mother was the ray of hope always tried to bear him up. (Support)

Pamela and Aris discuss insurrection, a black mathematician fellowship, and diversity statements.

Companies primarily adopt compliance programs because they recognize the need to mitigate risk. Leaders want to get the end result of a safer workplace with less legal exposure. Merely adopting a compliance program, however, without comprehensive implementation, may not yield the return on investment that a leader wants. On any given day, we can turn to the Department of Justice website to read press releases of criminal indictments for white collar crime. Many of the defendants in those cases began without any intention to break laws. Yet a lack of a clearly defined business model, or well-engineered compliance system, put those people into the cross hairs of a government investigation. High legal costs and criminal proceedings followed. All businesses stand vulnerable to the dangers of a government investigation. For these reasons, leaders should take steps to minimize their exposure. That means they should put plans in place to show a commitment to transparency, compliance, and good corporate citizenship. Our team at Compliance Mitigation has identified 10 reasons that compliance programs may fail in businesses:   A Failure to Appreciate Risk Leader should begin with an honest assessment of the risks the company may face. To get the right answers, they may ask Socratic questions. Rather than starting from the perspective of the company leader, questions should come from the mindset of an investigator. Those people will be cynical. If company leaders do not anticipate such questions, they may fail to appreciate their exposure to risk. Company leaders frequently strive to: Provide products or services to satisfy customer needs, Create jobs and paychecks for employees, Contribute to the building of stronger, more vibrant communities, and Earn an acceptable return on investment for shareholders. A company may not have the luxury of hiring an entire team or department to contemplate risk exposure. Yet if they do not understand the risk, they may not see value in a compliance program. If leaders do not see how a compliance program can strengthen the overall health of the organization, they may undermine its effectiveness. Without a good compliance program, the company and its team leaders may face harsher scrutiny from regulators and investigators. For these reasons, proper training should highlight failures and the accompanying costs of a bad compliance program.    Lack of Leadership Buy-In When it comes to compliance, leaders should recognize that the company’s commitment to ethics starts at the top. If leaders do not embrace the principles of good conduct, team members will not take compliance seriously. Compliance programs that send mixed or inconsistent messaging leave the company vulnerable to liability. That liability can include exposure to internal fraud, lawsuits from customers, investigations by government regulators or law enforcement. Good training should profile examples of the fallout that has come from such failures in compliance.   A Paucity of Resources Devoted to Compliance: Failing to devote financial resources to support compliance training exposes a company to more risk. If an investigation begins, and the company cannot show a deliberate, consistent investment in the pursuit of excellence, authorities will be less likely to see the business or its leaders as good actors. On the contrary, investigators may accuse the business and the responsible parties of operating from a state of “willful blindness,” a term we heard a lot about while our team members were in prison. Compliance training does not have to be a drain on the company’s resources. In fact, when leaders design compliance programs to demonstrate a commitment to transparency, they may be simultaneously investing in corporate messaging. That better messaging can lead to better efficiencies, helping every team member get a full grasp of how the company operates and achieves excellence. With such a commitment, every team member may work collaboratively, in accordance with corporate goals. When leaders view compliance as an essential part of the corporate mission, they devote the appropriate resources. Those resources may advance corporate success, while simultaneously mitigating risks.   Demoralizing Compliance Departments When company leaders view compliance programs as being wasteful expenses, team members won’t take the program seriously. Unfortunately, if anything should ever happen that brings the company to the attention of government investigators, leaders should expect to pay a heavy price. Clearly, a company succeeds by devoting resources to sales teams, marketing teams, and operational teams that build thriving businesses. Yet leaders should model themselves after athletic coaches that require players to train on fundamentals. Coaches invest in defense and offense, not just offense. Likewise, business leaders should invest in defensive measures that will protect all team members. If a government investigation begins, the value of an effective compliance program will become readily apparent. On the other hand, a demoralized or feeble compliance program will only hurt the organization. Government attorneys will use flawed policies as evidence of the company’s devotion to willful blindness. Indeed, the Harvard Business Review published an article describing how the Department of Justice tasks prosecutors “to determine whether a corporation’s compliance programs is merely a ‘paper program’ or whether it was designed, implemented, reviewed, and revised, as appropriate, in an effective manner.” https://hbr.org/2018/03/why-compliance-programs-fail   The Policies Lack Clear Instruction and do not Relate to the Business A good compliance training program engages team members. If leaders do not supplement off-the-shelf compliance programs with additional instruction that teach or inspire team members, they miss an opportunity. Neither boilerplate language, nor dense legal jargon, will help. An option would include supplementing training exercises with human case studies. Leaders may profile the story of a person convicted of a white-collar crime. Task participants with identifying what went wrong. Perhaps encourage them to come up with strategies that may have lessened the risk. Use the feedback as a resource to strengthen corporate processes and procedures. Another option would be to create cloud-based, on-demand video training that encourages the development of critical-thinking skills.   Misplaced Incentives A company can doom a compliance program by failing to align compensation with good corporate behavior. If a company incentivizes people to get sales by any means necessary, they may simultaneously create a culture of non-compliance. Many people serve prison sentences for violating laws related to: Foreign Corrupt Practices Act Sherman Antitrust Laws Money Laundering Identity Theft Bribery Mail Fraud Wire Fraud Honest Services Fraud Securities Fraud While in prison, many of those people complain that they only did what their companies wanted them to do. The employees lost, and in many cases, the companies lost as well—paying enormous financial penalties. Good compliance programs will incentivize excellence in every area, providing training that shows a commitment to good corporate citizenship.   Inadequate Communication and Training Corporate leadership requires clear and consistent messaging that shows how leaders define excellence. Leaders that do not communicate the company’s commitment to integrity give license for other people to violate rules. The training should show that the company places a high value on excellence—and placing a high value on excellence means training for excellence in communications, from the top down. The communication channels should flow both ways. People at every level in the organization should have an opportunity to ask questions or express concerns. If an employee sees something wrong, the person should have some mechanism to speak up without fear of retaliation. Without that two-way communications and training, the company may weaken a compliance program.   Outsourced Noncompliance A company cannot escape punishment from law enforcement, or escape liability from regulators, by outsourcing noncompliance. Both the Department of Justice and regulatory agencies have launched government investigations that punished entities for contracting with outside contractors or third parties that facilitate illegal behavior. Further, when leaders look for plausible deniability by using the “it’s-not-my-fault” defense, they expose themselves to accusations of being willfully blind to illegal or corrupt behavior. Bad and inconsistent messaging threatens the entire the organization.   Failing to Monitor or Audit Compliance If the company doesn’t show a commitment to maintaining compliance, the team members will ignore the training. They may do what is necessary to pass an internal quiz on what they have learned. As soon as they leave the training session, however, many of those people go about business in a manner that shows a total disregard for what the compliance program ostensibly teaches. In contrast, a company with a true commitment to compliance will show team members how the company’s leadership invests heavily in corporate excellence. Besides ongoing training, they may show a commitment to monitoring by sponsoring a private “hotline” that encourages people to report noncompliance. They may conduct internal audits or perform phantom calls to see how people will respond. Then, the company may announce its findings regularly. When team members understand that the business’s leaders monitor and audit compliance, people will show more commitment to operating in harmony with what they’ve learned through compliance training.   Inconsistent Enforcement and Discipline If a company is harsh on low-level employees, but it allows rainmakers or leaders to get away with noncompliance, the compliance program will fail as a resource to protect against government investigations. As the above-quoted Harvard Business Review article noted, prosecutors will deal harshly with companies that do not treat the compliance program as an integral part of the organization To grant a non-prosecution agreement, prosecutors will assess the company’s policies—including records the company keeps on disciplinary or corrective measures for noncompliance. The following 20-page report that the Department of Justice published will help leaders grasp the “critical factors” prosecutors will use when assessing “the comprehensiveness of the compliance programs.” https://www.justice.gov/criminal-fraud/page/file/937501/download That document shows a compliance program should provide a clear message that leadership will not tolerate misconduct. The program cannot succeed if prosecutors determine that policies do not apply to people in senior leadership positions. According to the document: “The company’s top leaders set the tone for the rest of the company. Prosecutors should examine the extent to which senior management have clearly articulated the company’s ethical standards, conveyed and disseminated them in clear and unambiguous terms, and demonstrated rigorous adherence by example. Prosecutors should also examine how middle management, in turn, have reinforced those standards and encouraged employees to abide by them.”

Merriam-Webster's Word of the Day for December 8, 2020 is: paucity • PAW-suh-tee • noun 1 : smallness of number : fewness 2 : smallness of quantity : dearth Examples: The manager overheard two customers complaining about the paucity of stylish designs in the store. "But dire wolves, which were about 25 percent heavier than gray wolves, never flourished in Asia, Dr. Ni and his collaborators suggested, based on the paucity of fossils found there (this is the first)." — Katherine Kornei, The New York Times, 15 Oct. 2020 Did you know? Here's a little information about paucity: the word was first recorded in English in the 15th century, and it comes to us from the Latin paucitas ("smallness of number"), which is derived from the adjective paucus ("little"). The word's origin informs its use; paucity can be used to refer to a littleness of numbers (as in "a paucity of facts/studies") or quantity ("a paucity of evidence"), or one can use paucity when speaking of abstract concepts, as in "a paucity of experience/knowledge."

Hey! You are listening to the KIA series by TalkCXOLife and before I introduce our next guest, I hope and pray you and your loved ones are healthy, safe and sound and continue to be so during these very trying times! We are in this together and so may our commitment to ensure the wellbeing of ourselves and the society at large prevail! Alright, no preaching now coz it isn’t fun at all is it. But you know what is? Imagine playing the drums or snakes and ladders or cuddling a pet or whipping up a dish whilst at work. No, we aren’t talking about working from home which is what offices the world over have had to adhere to, almost overnight. But about actually playing and having fun at work. Meet Nishant Parashar, Founder of engage4more, a leading employee engagement firm in Mumbai. Nishant who was also awarded the Business World Entrepreneur of the Year Award in 2010, within about a year of setting up engage4more, shares how engaging with people and eliciting a response from them through events, activities have driven him since young. In this second segment, Nishant shares some of the key challenges a corporate faces in effectively deploying employee engagement, namely the BIB – bandwidth, ideas and budget. He believes it is unfair to expect HR to take the onus for employee engagement when the function critically demands marketing, response generation, which the HR is ill-equipped to handle. Nishant also speaks about his company’s fastest growing segment – providing employee engagement services for free! Yes, you heard it right. He foresees 1 lac offices signing up for this segment which has clocked a whopping 250% q-o-q growth rate and has about 1670 offices currently using the 4500 free activities engage4more offers. We also speak on why having fun and engaging maximum senses simultaneously is imperative for effective employee engagement. Stay tuned! 

In this episode of the MDedge Psychcast, we revisit an interview that Lorenzo Norris, MD, MDedge Psychiatry editor in chief, conducted earlier this year by phone with two psychiatrists working in New Mexico. Dr. Norris spoke with Caroline Bonham, MD, and Avi Kriechman, MD, about enhancing resilience in rural communities. Dr. Bonham is vice chair in the department of psychiatry and behavioral sciences at the University of New Mexico, Albuquerque. Dr. Kriechman is assistant professor in that department, and a pediatrician who works on youth suicide prevention and school mental health.   Understanding risks of suicide in rural communities Nationally, suicide rates have been going up across the United States, including in rural communities. Paucity of mental health clinicians supporting youth and their families has implications for youth suicide. Impact of structural poverty and the opioid epidemic also have implications for these rising rates.  Identifying resources within small, rural communities Communities have resources that are not tapped into enough by clinicians, such as churches, teachers, and community health workers. Recent studies show that most communities have members who know people at risk and want to help. It is important for clinicians to think outside of the box so that they help facilitate the use of natural resources/strengths that exist within small communities, such as food pantries that operate out of mental health centers, spiritual organizations, and aftercare programs in schools.  Building resilience among individuals The literature shows that engaging people in a collaborative, transparent process of care is effective. If community members who do not have problems, such as suicidality, physical ailments, or a severe mental illness, are taught to reach out, destigmatize, and facilitate treatment, the mental health outcomes of patients are better. Concrete, feasible intervention would be to work with gun store owners about the risk factors for suicide, how to encourage people to seek help. Some police departments provide education about the safe storage of firearms. References Curtin SC and Heron M. Death rates due to suicide and homicide among persons aged 10-24: United States, 2000-2017. NCHS Data Brief. 2019 Oct;(352):1-8. Altschul DB et al. State legislative approach to enumerating behavioral health workforce shortages: Lessons learned in New Mexico. Am J Prev Med. 2018 Jun;54(6 suppl 3):S220-9. Bonham C et al. Training psychiatrists for rural practice: A 20-year follow-up. Acad Psychiatry. 2014 Oct;38(5):623-6. Kriechman A et al. Expanding the vision: The strength-based, community-oriented child and adolescent psychiatrist working in schools. Child Adolesc Psychiatr Clin N Am. 2010 Jan;19(1):149-62. For more MDedge Podcasts, go to mdedge.com/podcasts Email the show: podcasts@mdedge.com Interact with us on Twitter: @MDedgePsych

Lazarus Jackson (@lazchance) and Kyle Maggio (@kylemaggio) talk about the Detroit Pistons' win over the New York Knicks, the similarities between the Knicks drafting Frank Ntilikina and the Pistons drafting Sekou Doumbouya, and what both teams could do with Andre Drummond this upcoming offseason.Find Kyle's work at The Knicks Wall and at @WhistleSports.Pistons Vs Everybody is brought to you by our partners, Manscaped and UNTUCKit. Go to https://www.manscaped.com/ and enter BLUEWIRE to get 20% off and free shipping on your order, and go to https://www.untuckit.com/ and enter BLUE at checkout to save 20% on a smart, relaxed, untucked shirt.

He brought 45 First Amendment cases to the United States Supreme Court between 1939 and 1955. His success rate before the court was second only to future Supreme Court Justice Thurgood Marshall. He handled as many as 50 major cases a year and is responsible for much of the First Amendment doctrine we take for granted today. Who was this man — and why have most free speech scholars and activists never heard of him? On today’s episode of So to Speak: The Free Speech Podcast, we discuss the life and legacy of Hayden C. Covington, who for many years was legal counsel for the Jehovah’s Witnesses. We are joined by distinguished First Amendment scholar and recurring So to Speak guest Ronald K.L. Collins. Collins is the author of the Florida International University Law Review article “Thoughts on Hayden C. Covington and the Paucity of Litigation Scholarship.”  Show notes: Podcast transcript Video of podcast interview “Thoughts on Hayden C. Covington and the Paucity of Litigation Scholarship” by Ronald K.L. Collins Cases discussed: Minersville School District v. Gobitis (1940), Chaplinksy v. New Hampshire (1942), West Virginia State Board of Education v. Barnette (1943), Virginia State Board of Pharmacy v. Virginia Citizens Consumer Council (1976) Ronald K.L. Collins’ First Amendment News “First Things First: A Modern Coursebook on Free Speech Fundamentals” by Ronald K.L. Collins, Will Creeley, and David Hudson (managing editor, Jackie Farmer) “We Must Not Be Afraid to Be Free: Stories of Free Expression in America” by Ronald K.L Collins & Sam Chaltain www.sotospeakpodcast.com Follow us on Twitter: https://www.twitter.com/freespeechtalk Like us on Facebook: https://www.facebook.com/sotospeakpodcast Email us: sotospeak@thefire.org

In this episode, we discuss the etiologies, clinical presentation and treatment of thrombocytosis. From reactive thrombocytosis to autonomous thrombocytosis, we talk about it all. Our medicine minute addresses a World War II era therapy that is no longer used, but might be considered for a specific population!If you haven't already, listen to our accompanying podcast - A Paucity of Platelets, to learn about the opposite disorder - Thrombocytopenia!

Tax Notes Talk host David Stewart catches up with Jeremy Cape of Squire Patton Boggs in London about the current state of Brexit.For additional coverage, read these articles in Tax Notes:The U.K. Conservative Party’s Paucity of Tax Policy ThinkingJohnson’s Election Call Rejected as MPs Approve Brexit BillMPs Win Control of Agenda in Move to Block No-Deal BrexitJohnson Defends Plan to Shut Parliament Weeks Ahead of BrexitU.K. Prime Minister-Elect Johnson Urged to Back Businesses***This episode is sponsored by University of California, Irvine Law School’s Graduate Tax Program. For more information, visit law.uci.edu/gradtax.

What do you do when cracks show up in your life? Paul and Christina take a look at this and other ideas in this week's show.

08-30-19 Hour 3

Morsels of paucity, strict - nothing funny Flush now with sharp suits - power & money Adding those ever more revenue streams Hard work paid off... The cat got the cream

Ashlynn Salzano and Drew Lausch discuss instagram deleting important content, 16 small things that make New Yorks furious, some good news and some dumb crime.    NEW YORKER ARITCLE https://www.timeout.com/newyork/blog/16-small-things-that-fill-every-new-yorker-with-irrational-rage-010417?fbclid=IwAR3d34ojNc_h70QXvSRauFcFyLMHRiiesEuK5r8AXQwV8VVG-e1DYIFWkGE  GOOD NEWS: https://www.msn.com/en-us/news/good-news/a-student-brought-his-baby-to-class-because-he-didnt-have-child-care-his-professor-lent-a-hand/ar-BBUlIlH DUMB CRIME: http://www.newser.com/story/272340/angry-fast-food-patrons-cause-chaos-at-taco-bell-dominos.html Drew Lausch @realdrewlausch  

03-13-19 Hour 3

In this episode we talk all about platelets! We outline the physiology of platelets, common etiologies of thrombocytopenia, investigations and management. Finally, we'll take you through the need to know risks of platelet transfusions to help you in talking to patients on the ward!

Dr Ivor Popovich presents examples of evidence-based decision making during ward calls. We also highlight some recommendations from Choosing Wisely and give an update on death certification. The Intern Suppository – Ivor’s EBM blog The Rational Clinical Examination – JAMA Plain film in small bowel obstruction The gas-less abdomen Paucity of gas Non-specific bowel gas … Read More Read More

Intriguing discussion and interview with Jim Smeeding, MBA president of JestaRx Group and Elie Khalife CEO of KeyCentrix about the impact of Medical Marijuana on therapies for patients and multiple diseases states where Specialty Pharmacy is focused.  Introductions - Jim Smeeding's background & founding meember of the National Association of Specialty Pharmacies  Overview of Medical Marijuana today Ability and interest of medical professionals to participate Physicians /MD’s qualifying patient as medically eligible  Paucity of Data and legislative indications without science  Interest by pharmacists to participate in Medical Marijuana as a medical alternative VA data - reduced use of opioids when Medical Marijuana is offered

Adventures of a Pus Whisperer.

The Proposal, Plan, Place,Purpose, Promise, Paucity, and Prayer

The Melchizedek Teachings in the Orient (1027.1) 94:0.1 THE early teachers of the Salem religion penetrated to the remotest tribes of Africa and Eurasia, ever preaching Machiventa’s gospel of man’s faith and trust in the one universal God as the only price of obtaining divine favor. Melchizedek’s covenant with Abraham was the pattern for all the early propaganda that went out from Salem and other centers. Urantia has never had more enthusiastic and aggressive missionaries of any religion than these noble men and women who carried the teachings of Melchizedek over the entire Eastern Hemisphere. These missionaries were recruited from many peoples and races, and they largely spread their teachings through the medium of native converts. They established training centers in different parts of the world where they taught the natives the Salem religion and then commissioned these pupils to function as teachers among their own people. 1. The Salem Teachings in Vedic India (1027.2) 94:1.1 In the days of Melchizedek, India was a cosmopolitan country which had recently come under the political and religious dominance of the Aryan-Andite invaders from the north and west. At this time only the northern and western portions of the peninsula had been extensively permeated by the Aryans. These Vedic newcomers had brought along with them their many tribal deities. Their religious forms of worship followed closely the ceremonial practices of their earlier Andite forebears in that the father still functioned as a priest and the mother as a priestess, and the family hearth was still utilized as an altar. (1027.3) 94:1.2 The Vedic cult was then in process of growth and metamorphosis under the direction of the Brahman caste of teacher-priests, who were gradually assuming control over the expanding ritual of worship. The amalgamation of the onetime thirty-three Aryan deities was well under way when the Salem missionaries penetrated the north of India. (1027.4) 94:1.3 The polytheism of these Aryans represented a degeneration of their earlier monotheism occasioned by their separation into tribal units, each tribe having its venerated god. This devolution of the original monotheism and trinitarianism of Andite Mesopotamia was in process of resynthesis in the early centuries of the second millennium before Christ. The many gods were organized into a pantheon under the triune leadership of Dyaus pitar, the lord of heaven; Indra, the tempestuous lord of the atmosphere; and Agni, the three-headed fire god, lord of the earth and the vestigial symbol of an earlier Trinity concept. (1027.5) 94:1.4 Definite henotheistic developments were paving the way for an evolved monotheism. Agni, the most ancient deity, was often exalted as the father-head of the entire pantheon. The deity-father principle, sometimes called Prajapati, sometimes termed Brahma, was submerged in the theologic battle which the Brahman priests later fought with the Salem teachers. The Brahman was conceived as the energy-divinity principle activating the entire Vedic pantheon. (1028.1) 94:1.5 The Salem missionaries preached the one God of Melchizedek, the Most High of heaven. This portrayal was not altogether disharmonious with the emerging concept of the Father-Brahma as the source of all gods, but the Salem doctrine was nonritualistic and hence ran directly counter to the dogmas, traditions, and teachings of the Brahman priesthood. Never would the Brahman priests accept the Salem teaching of salvation through faith, favor with God apart from ritualistic observances and sacrificial ceremonials. (1028.2) 94:1.6 The rejection of the Melchizedek gospel of trust in God and salvation through faith marked a vital turning point for India. The Salem missionaries had contributed much to the loss of faith in all the ancient Vedic gods, but the leaders, the priests of Vedism, refused to accept the Melchizedek teaching of one God and one simple faith. (1028.3) 94:1.7 The Brahmans culled the sacred writings of their day in an effort to combat the Salem teachers, and this compilation, as later revised, has come on down to modern times as the Rig-Veda, one of the most ancient of sacred books. The second, third, and fourth Vedas followed as the Brahmans sought to crystallize, formalize, and fix their rituals of worship and sacrifice upon the peoples of those days. Taken at their best, these writings are the equal of any other body of similar character in beauty of concept and truth of discernment. But as this superior religion became contaminated with the thousands upon thousands of superstitions, cults, and rituals of southern India, it progressively metamorphosed into the most variegated system of theology ever developed by mortal man. An examination of the Vedas will disclose some of the highest and some of the most debased concepts of Deity ever to be conceived. 2. Brahmanism (1028.4) 94:2.1 As the Salem missionaries penetrated southward into the Dravidian Deccan, they encountered an increasing caste system, the scheme of the Aryans to prevent loss of racial identity in the face of a rising tide of the secondary Sangik peoples. Since the Brahman priest caste was the very essence of this system, this social order greatly retarded the progress of the Salem teachers. This caste system failed to save the Aryan race, but it did succeed in perpetuating the Brahmans, who, in turn, have maintained their religious hegemony in India to the present time. (1028.5) 94:2.2 And now, with the weakening of Vedism through the rejection of higher truth, the cult of the Aryans became subject to increasing inroads from the Deccan. In a desperate effort to stem the tide of racial extinction and religious obliteration, the Brahman caste sought to exalt themselves above all else. They taught that the sacrifice to deity in itself was all-efficacious, that it was all-compelling in its potency. They proclaimed that, of the two essential divine principles of the universe, one was Brahman the deity, and the other was the Brahman priesthood. Among no other Urantia peoples did the priests presume to exalt themselves above even their gods, to relegate to themselves the honors due their gods. But they went so absurdly far with these presumptuous claims that the whole precarious system collapsed before the debasing cults which poured in from the surrounding and less advanced civilizations. The vast Vedic priesthood itself floundered and sank beneath the black flood of inertia and pessimism which their own selfish and unwise presumption had brought upon all India. (1029.1) 94:2.3 The undue concentration on self led certainly to a fear of the nonevolutionary perpetuation of self in an endless round of successive incarnations as man, beast, or weeds. And of all the contaminating beliefs which could have become fastened upon what may have been an emerging monotheism, none was so stultifying as this belief in transmigration — the doctrine of the reincarnation of souls — which came from the Dravidian Deccan. This belief in the weary and monotonous round of repeated transmigrations robbed struggling mortals of their long-cherished hope of finding that deliverance and spiritual advancement in death which had been a part of the earlier Vedic faith. (1029.2) 94:2.4 This philosophically debilitating teaching was soon followed by the invention of the doctrine of the eternal escape from self by submergence in the universal rest and peace of absolute union with Brahman, the oversoul of all creation. Mortal desire and human ambition were effectually ravished and virtually destroyed. For more than two thousand years the better minds of India have sought to escape from all desire, and thus was opened wide the door for the entrance of those later cults and teachings which have virtually shackled the souls of many Hindu peoples in the chains of spiritual hopelessness. Of all civilizations, the Vedic-Aryan paid the most terrible price for its rejection of the Salem gospel. (1029.3) 94:2.5 Caste alone could not perpetuate the Aryan religio-cultural system, and as the inferior religions of the Deccan permeated the north, there developed an age of despair and hopelessness. It was during these dark days that the cult of taking no life arose, and it has ever since persisted. Many of the new cults were frankly atheistic, claiming that such salvation as was attainable could come only by man’s own unaided efforts. But throughout a great deal of all this unfortunate philosophy, distorted remnants of the Melchizedek and even the Adamic teachings can be traced. (1029.4) 94:2.6 These were the times of the compilation of the later scriptures of the Hindu faith, the Brahmanas and the Upanishads. Having rejected the teachings of personal religion through the personal faith experience with the one God, and having become contaminated with the flood of debasing and debilitating cults and creeds from the Deccan, with their anthropomorphisms and reincarnations, the Brahmanic priesthood experienced a violent reaction against these vitiating beliefs; there was a definite effort to seek and to find true reality. The Brahmans set out to deanthropomorphize the Indian concept of deity, but in so doing they stumbled into the grievous error of depersonalizing the concept of God, and they emerged, not with a lofty and spiritual ideal of the Paradise Father, but with a distant and metaphysical idea of an all-encompassing Absolute. (1029.5) 94:2.7 In their efforts at self-preservation the Brahmans had rejected the one God of Melchizedek, and now they found themselves with the hypothesis of Brahman, that indefinite and illusive philosophic self, that impersonal and impotent it which has left the spiritual life of India helpless and prostrate from that unfortunate day to the twentieth century. (1029.6) 94:2.8 It was during the times of the writing of the Upanishads that Buddhism arose in India. But despite its successes of a thousand years, it could not compete with later Hinduism; despite a higher morality, its early portrayal of God was even less well-defined than was that of Hinduism, which provided for lesser and personal deities. Buddhism finally gave way in northern India before the onslaught of a militant Islam with its clear-cut concept of Allah as the supreme God of the universe. 3. Brahmanic Philosophy (1030.1) 94:3.1 While the highest phase of Brahmanism was hardly a religion, it was truly one of the most noble reaches of the mortal mind into the domains of philosophy and metaphysics. Having started out to discover final reality, the Indian mind did not stop until it had speculated about almost every phase of theology excepting the essential dual concept of religion: the existence of the Universal Father of all universe creatures and the fact of the ascending experience in the universe of these very creatures as they seek to attain the eternal Father, who has commanded them to be perfect, even as he is perfect. (1030.2) 94:3.2 In the concept of Brahman the minds of those days truly grasped at the idea of some all-pervading Absolute, for this postulate was at one and the same time identified as creative energy and cosmic reaction. Brahman was conceived to be beyond all definition, capable of being comprehended only by the successive negation of all finite qualities. It was definitely a belief in an absolute, even an infinite, being, but this concept was largely devoid of personality attributes and was therefore not experiencible by individual religionists. (1030.3) 94:3.3 Brahman-Narayana was conceived as the Absolute, the infinite IT IS, the primordial creative potency of the potential cosmos, the Universal Self existing static and potential throughout all eternity. Had the philosophers of those days been able to make the next advance in deity conception, had they been able to conceive of the Brahman as associative and creative, as a personality approachable by created and evolving beings, then might such a teaching have become the most advanced portraiture of Deity on Urantia since it would have encompassed the first five levels of total deity function and might possibly have envisioned the remaining two. (1030.4) 94:3.4 In certain phases the concept of the One Universal Oversoul as the totality of the summation of all creature existence led the Indian philosophers very close to the truth of the Supreme Being, but this truth availed them naught because they failed to evolve any reasonable or rational personal approach to the attainment of their theoretic monotheistic goal of Brahman-Narayana. (1030.5) 94:3.5 The karma principle of causality continuity is, again, very close to the truth of the repercussional synthesis of all time-space actions in the Deity presence of the Supreme; but this postulate never provided for the co-ordinate personal attainment of Deity by the individual religionist, only for the ultimate engulfment of all personality by the Universal Oversoul. (1030.6) 94:3.6 The philosophy of Brahmanism also came very near to the realization of the indwelling of the Thought Adjusters, only to become perverted through the misconception of truth. The teaching that the soul is the indwelling of the Brahman would have paved the way for an advanced religion had not this concept been completely vitiated by the belief that there is no human individuality apart from this indwelling of the Universal One. (1030.7) 94:3.7 In the doctrine of the merging of the self-soul with the Oversoul, the theologians of India failed to provide for the survival of something human, something new and unique, something born of the union of the will of man and the will of God. The teaching of the soul’s return to the Brahman is closely parallel to the truth of the Adjuster’s return to the bosom of the Universal Father, but there is something distinct from the Adjuster which also survives, the morontial counterpart of mortal personality. And this vital concept was fatally absent from Brahmanic philosophy. (1031.1) 94:3.8 Brahmanic philosophy has approximated many of the facts of the universe and has approached numerous cosmic truths, but it has all too often fallen victim to the error of failing to differentiate between the several levels of reality, such as absolute, transcendental, and finite. It has failed to take into account that what may be finite-illusory on the absolute level may be absolutely real on the finite level. And it has also taken no cognizance of the essential personality of the Universal Father, who is personally contactable on all levels from the evolutionary creature’s limited experience with God on up to the limitless experience of the Eternal Son with the Paradise Father. 4. The Hindu Religion (1031.2) 94:4.1 With the passing of the centuries in India, the populace returned in measure to the ancient rituals of the Vedas as they had been modified by the teachings of the Melchizedek missionaries and crystallized by the later Brahman priesthood. This, the oldest and most cosmopolitan of the world’s religions, has undergone further changes in response to Buddhism and Jainism and to the later appearing influences of Mohammedanism and Christianity. But by the time the teachings of Jesus arrived, they had already become so Occidentalized as to be a “white man’s religion,” hence strange and foreign to the Hindu mind. (1031.3) 94:4.2 Hindu theology, at present, depicts four descending levels of deity and divinity: (1031.4) 94:4.3 1. The Brahman, the Absolute, the Infinite One, the IT IS. (1031.5) 94:4.4 2. The Trimurti, the supreme trinity of Hinduism. In this association Brahma, the first member, is conceived as being self-created out of the Brahman — infinity. Were it not for close identification with the pantheistic Infinite One, Brahma could constitute the foundation for a concept of the Universal Father. Brahma is also identified with fate. (1031.6) 94:4.5 The worship of the second and third members, Siva and Vishnu, arose in the first millennium after Christ. Siva is lord of life and death, god of fertility, and master of destruction. Vishnu is extremely popular due to the belief that he periodically incarnates in human form. In this way, Vishnu becomes real and living in the imaginations of the Indians. Siva and Vishnu are each regarded by some as supreme over all. (1031.7) 94:4.6 3. Vedic and post-Vedic deities. Many of the ancient gods of the Aryans, such as Agni, Indra, Soma, have persisted as secondary to the three members of the Trimurti. Numerous additional gods have arisen since the early days of Vedic India, and these have also been incorporated into the Hindu pantheon. (1031.8) 94:4.7 4. The demigods: supermen, semigods, heroes, demons, ghosts, evil spirits, sprites, monsters, goblins, and saints of the later-day cults. (1031.9) 94:4.8 While Hinduism has long failed to vivify the Indian people, at the same time it has usually been a tolerant religion. Its great strength lies in the fact that it has proved to be the most adaptive, amorphic religion to appear on Urantia. It is capable of almost unlimited change and possesses an unusual range of flexible adjustment from the high and semimonotheistic speculations of the intellectual Brahman to the arrant fetishism and primitive cult practices of the debased and depressed classes of ignorant believers. (1032.1) 94:4.9 Hinduism has survived because it is essentially an integral part of the basic social fabric of India. It has no great hierarchy which can be disturbed or destroyed; it is interwoven into the life pattern of the people. It has an adaptability to changing conditions that excels all other cults, and it displays a tolerant attitude of adoption toward many other religions, Gautama Buddha and even Christ himself being claimed as incarnations of Vishnu. (1032.2) 94:4.10 Today, in India, the great need is for the portrayal of the Jesusonian gospel — the Fatherhood of God and the sonship and consequent brotherhood of all men, which is personally realized in loving ministry and social service. In India the philosophical framework is existent, the cult structure is present; all that is needed is the vitalizing spark of the dynamic love portrayed in the original gospel of the Son of Man, divested of the Occidental dogmas and doctrines which have tended to make Michael’s life bestowal a white man’s religion. 5. The Struggle for Truth in China (1032.3) 94:5.1 As the Salem missionaries passed through Asia, spreading the doctrine of the Most High God and salvation through faith, they absorbed much of the philosophy and religious thought of the various countries traversed. But the teachers commissioned by Melchizedek and his successors did not default in their trust; they did penetrate to all peoples of the Eurasian continent, and it was in the middle of the second millennium before Christ that they arrived in China. At See Fuch, for more than one hundred years, the Salemites maintained their headquarters, there training Chinese teachers who taught throughout all the domains of the yellow race. (1032.4) 94:5.2 It was in direct consequence of this teaching that the earliest form of Taoism arose in China, a vastly different religion than the one which bears that name today. Early or proto-Taoism was a compound of the following factors: (1032.5) 94:5.3 1. The lingering teachings of Singlangton, which persisted in the concept of Shang-ti, the God of Heaven. In the times of Singlangton the Chinese people became virtually monotheistic; they concentrated their worship on the One Truth, later known as the Spirit of Heaven, the universe ruler. And the yellow race never fully lost this early concept of Deity, although in subsequent centuries many subordinate gods and spirits insidiously crept into their religion. (1032.6) 94:5.4 2. The Salem religion of a Most High Creator Deity who would bestow his favor upon mankind in response to man’s faith. But it is all too true that, by the time the Melchizedek missionaries had penetrated to the lands of the yellow race, their original message had become considerably changed from the simple doctrines of Salem in the days of Machiventa. (1032.7) 94:5.5 3. The Brahman-Absolute concept of the Indian philosophers, coupled with the desire to escape all evil. Perhaps the greatest extraneous influence in the eastward spread of the Salem religion was exerted by the Indian teachers of the Vedic faith, who injected their conception of the Brahman — the Absolute — into the salvationistic thought of the Salemites. (1033.1) 94:5.6 This composite belief spread through the lands of the yellow and brown races as an underlying influence in religio-philosophic thought. In Japan this proto-Taoism was known as Shinto, and in this country, far-distant from Salem of Palestine, the peoples learned of the incarnation of Machiventa Melchizedek, who dwelt upon earth that the name of God might not be forgotten by mankind.* (1033.2) 94:5.7 In China all of these beliefs were later confused and compounded with the ever-growing cult of ancestor worship. But never since the time of Singlangton have the Chinese fallen into helpless slavery to priestcraft. The yellow race was the first to emerge from barbaric bondage into orderly civilization because it was the first to achieve some measure of freedom from the abject fear of the gods, not even fearing the ghosts of the dead as other races feared them. China met her defeat because she failed to progress beyond her early emancipation from priests; she fell into an almost equally calamitous error, the worship of ancestors. (1033.3) 94:5.8 But the Salemites did not labor in vain. It was upon the foundations of their gospel that the great philosophers of sixth-century China built their teachings. The moral atmosphere and the spiritual sentiments of the times of Lao-tse and Confucius grew up out of the teachings of the Salem missionaries of an earlier age. 6. Lao-Tse and Confucius (1033.4) 94:6.1 About six hundred years before the arrival of Michael, it seemed to Melchizedek, long since departed from the flesh, that the purity of his teaching on earth was being unduly jeopardized by general absorption into the older Urantia beliefs. It appeared for a time that his mission as a forerunner of Michael might be in danger of failing. And in the sixth century before Christ, through an unusual co-ordination of spiritual agencies, not all of which are understood even by the planetary supervisors, Urantia witnessed a most unusual presentation of manifold religious truth. Through the agency of several human teachers the Salem gospel was restated and revitalized, and as it was then presented, much has persisted to the times of this writing. (1033.5) 94:6.2 This unique century of spiritual progress was characterized by great religious, moral, and philosophic teachers all over the civilized world. In China, the two outstanding teachers were Lao-tse and Confucius. (1033.6) 94:6.3 Lao-tse built directly upon the concepts of the Salem traditions when he declared Tao to be the One First Cause of all creation. Lao was a man of great spiritual vision. He taught that man’s eternal destiny was “everlasting union with Tao, Supreme God and Universal King.” His comprehension of ultimate causation was most discerning, for he wrote: “Unity arises out of the Absolute Tao, and from Unity there appears cosmic Duality, and from such Duality, Trinity springs forth into existence, and Trinity is the primal source of all reality.” “All reality is ever in balance between the potentials and the actuals of the cosmos, and these are eternally harmonized by the spirit of divinity.”* (1033.7) 94:6.4 Lao-tse also made one of the earliest presentations of the doctrine of returning good for evil: “Goodness begets goodness, but to the one who is truly good, evil also begets goodness.” (1033.8) 94:6.5 He taught the return of the creature to the Creator and pictured life as the emergence of a personality from the cosmic potentials, while death was like the returning home of this creature personality. His concept of true faith was unusual, and he too likened it to the “attitude of a little child.” (1034.1) 94:6.6 His understanding of the eternal purpose of God was clear, for he said: “The Absolute Deity does not strive but is always victorious; he does not coerce mankind but always stands ready to respond to their true desires; the will of God is eternal in patience and eternal in the inevitability of its expression.” And of the true religionist he said, in expressing the truth that it is more blessed to give than to receive: “The good man seeks not to retain truth for himself but rather attempts to bestow these riches upon his fellows, for that is the realization of truth. The will of the Absolute God always benefits, never destroys; the purpose of the true believer is always to act but never to coerce.” (1034.2) 94:6.7 Lao’s teaching of nonresistance and the distinction which he made between action and coercion became later perverted into the beliefs of “seeing, doing, and thinking nothing.” But Lao never taught such error, albeit his presentation of nonresistance has been a factor in the further development of the pacific predilections of the Chinese peoples. (1034.3) 94:6.8 But the popular Taoism of twentieth-century Urantia has very little in common with the lofty sentiments and the cosmic concepts of the old philosopher who taught the truth as he perceived it, which was: That faith in the Absolute God is the source of that divine energy which will remake the world, and by which man ascends to spiritual union with Tao, the Eternal Deity and Creator Absolute of the universes. (1034.4) 94:6.9 Confucius (Kung Fu-tze) was a younger contemporary of Lao in sixth-century China. Confucius based his doctrines upon the better moral traditions of the long history of the yellow race, and he was also somewhat influenced by the lingering traditions of the Salem missionaries. His chief work consisted in the compilation of the wise sayings of ancient philosophers. He was a rejected teacher during his lifetime, but his writings and teachings have ever since exerted a great influence in China and Japan. Confucius set a new pace for the shamans in that he put morality in the place of magic. But he built too well; he made a new fetish out of order and established a respect for ancestral conduct that is still venerated by the Chinese at the time of this writing. (1034.5) 94:6.10 The Confucian preachment of morality was predicated on the theory that the earthly way is the distorted shadow of the heavenly way; that the true pattern of temporal civilization is the mirror reflection of the eternal order of heaven. The potential God concept in Confucianism was almost completely subordinated to the emphasis placed upon the Way of Heaven, the pattern of the cosmos. (1034.6) 94:6.11 The teachings of Lao have been lost to all but a few in the Orient, but the writings of Confucius have ever since constituted the basis of the moral fabric of the culture of almost a third of Urantians. These Confucian precepts, while perpetuating the best of the past, were somewhat inimical to the very Chinese spirit of investigation that had produced those achievements which were so venerated. The influence of these doctrines was unsuccessfully combated both by the imperial efforts of Ch’in Shih Huang Ti and by the teachings of Mo Ti, who proclaimed a brotherhood founded not on ethical duty but on the love of God. He sought to rekindle the ancient quest for new truth, but his teachings failed before the vigorous opposition of the disciples of Confucius. (1034.7) 94:6.12 Like many other spiritual and moral teachers, both Confucius and Lao-tse were eventually deified by their followers in those spiritually dark ages of China which intervened between the decline and perversion of the Taoist faith and the coming of the Buddhist missionaries from India. During these spiritually decadent centuries the religion of the yellow race degenerated into a pitiful theology wherein swarmed devils, dragons, and evil spirits, all betokening the returning fears of the unenlightened mortal mind. And China, once at the head of human society because of an advanced religion, then fell behind because of temporary failure to progress in the true path of the development of that God-consciousness which is indispensable to the true progress, not only of the individual mortal, but also of the intricate and complex civilizations which characterize the advance of culture and society on an evolutionary planet of time and space. 7. Gautama Siddhartha (1035.1) 94:7.1 Contemporary with Lao-tse and Confucius in China, another great teacher of truth arose in India. Gautama Siddhartha was born in the sixth century before Christ in the north Indian province of Nepal. His followers later made it appear that he was the son of a fabulously wealthy ruler, but, in truth, he was the heir apparent to the throne of a petty chieftain who ruled by sufferance over a small and secluded mountain valley in the southern Himalayas. (1035.2) 94:7.2 Gautama formulated those theories which grew into the philosophy of Buddhism after six years of the futile practice of Yoga. Siddhartha made a determined but unavailing fight against the growing caste system. There was a lofty sincerity and a unique unselfishness about this young prophet prince that greatly appealed to the men of those days. He detracted from the practice of seeking individual salvation through physical affliction and personal pain. And he exhorted his followers to carry his gospel to all the world. (1035.3) 94:7.3 Amid the confusion and extreme cult practices of India, the saner and more moderate teachings of Gautama came as a refreshing relief. He denounced gods, priests, and their sacrifices, but he too failed to perceive the personality of the One Universal. Not believing in the existence of individual human souls, Gautama, of course, made a valiant fight against the time-honored belief in transmigration of the soul. He made a noble effort to deliver men from fear, to make them feel at ease and at home in the great universe, but he failed to show them the pathway to that real and supernal home of ascending mortals — Paradise — and to the expanding service of eternal existence. (1035.4) 94:7.4 Gautama was a real prophet, and had he heeded the instruction of the hermit Godad, he might have aroused all India by the inspiration of the revival of the Salem gospel of salvation by faith. Godad was descended through a family that had never lost the traditions of the Melchizedek missionaries. (1035.5) 94:7.5 At Benares Gautama founded his school, and it was during its second year that a pupil, Bautan, imparted to his teacher the traditions of the Salem missionaries about the Melchizedek covenant with Abraham; and while Siddhartha did not have a very clear concept of the Universal Father, he took an advanced stand on salvation through faith — simple belief. He so declared himself before his followers and began sending his students out in groups of sixty to proclaim to the people of India “the glad tidings of free salvation; that all men, high and low, can attain bliss by faith in righteousness and justice.” (1035.6) 94:7.6 Gautama’s wife believed her husband’s gospel and was the founder of an order of nuns. His son became his successor and greatly extended the cult; he grasped the new idea of salvation through faith but in his later years wavered regarding the Salem gospel of divine favor through faith alone, and in his old age his dying words were, “Work out your own salvation.” (1036.1) 94:7.7 When proclaimed at its best, Gautama’s gospel of universal salvation, free from sacrifice, torture, ritual, and priests, was a revolutionary and amazing doctrine for its time. And it came surprisingly near to being a revival of the Salem gospel. It brought succor to millions of despairing souls, and notwithstanding its grotesque perversion during later centuries, it still persists as the hope of millions of human beings. (1036.2) 94:7.8 Siddhartha taught far more truth than has survived in the modern cults bearing his name. Modern Buddhism is no more the teachings of Gautama Siddhartha than is Christianity the teachings of Jesus of Nazareth. 8. The Buddhist Faith (1036.3) 94:8.1 To become a Buddhist, one merely made public profession of the faith by reciting the Refuge: “I take my refuge in the Buddha; I take my refuge in the Doctrine; I take my refuge in the Brotherhood.” (1036.4) 94:8.2 Buddhism took origin in a historic person, not in a myth. Gautama’s followers called him Sasta, meaning master or teacher. While he made no superhuman claims for either himself or his teachings, his disciples early began to call him the enlightened one, the Buddha; later on, Sakyamuni Buddha. (1036.5) 94:8.3 The original gospel of Gautama was based on the four noble truths: (1036.6) 94:8.4 1. The noble truths of suffering. (1036.7) 94:8.5 2. The origins of suffering. (1036.8) 94:8.6 3. The destruction of suffering. (1036.9) 94:8.7 4. The way to the destruction of suffering. (1036.10) 94:8.8 Closely linked to the doctrine of suffering and the escape therefrom was the philosophy of the Eightfold Path: right views, aspirations, speech, conduct, livelihood, effort, mindfulness, and contemplation. It was not Gautama’s intention to attempt to destroy all effort, desire, and affection in the escape from suffering; rather was his teaching designed to picture to mortal man the futility of pinning all hope and aspirations entirely on temporal goals and material objectives. It was not so much that love of one’s fellows should be shunned as that the true believer should also look beyond the associations of this material world to the realities of the eternal future. (1036.11) 94:8.9 The moral commandments of Gautama’s preachment were five in number: (1036.12) 94:8.10 1. You shall not kill. (1036.13) 94:8.11 2. You shall not steal. (1036.14) 94:8.12 3. You shall not be unchaste. (1036.15) 94:8.13 4. You shall not lie. (1036.16) 94:8.14 5. You shall not drink intoxicating liquors. (1036.17) 94:8.15 There were several additional or secondary commandments, whose observance was optional with believers. (1036.18) 94:8.16 Siddhartha hardly believed in the immortality of the human personality; his philosophy only provided for a sort of functional continuity. He never clearly defined what he meant to include in the doctrine of Nirvana. The fact that it could theoretically be experienced during mortal existence would indicate that it was not viewed as a state of complete annihilation. It implied a condition of supreme enlightenment and supernal bliss wherein all fetters binding man to the material world had been broken; there was freedom from the desires of mortal life and deliverance from all danger of ever again experiencing incarnation. (1037.1) 94:8.17 According to the original teachings of Gautama, salvation is achieved by human effort, apart from divine help; there is no place for saving faith or prayers to superhuman powers. Gautama, in his attempt to minimize the superstitions of India, endeavored to turn men away from the blatant claims of magical salvation. And in making this effort, he left the door wide open for his successors to misinterpret his teaching and to proclaim that all human striving for attainment is distasteful and painful. His followers overlooked the fact that the highest happiness is linked with the intelligent and enthusiastic pursuit of worthy goals, and that such achievements constitute true progress in cosmic self-realization. (1037.2) 94:8.18 The great truth of Siddhartha’s teaching was his proclamation of a universe of absolute justice. He taught the best godless philosophy ever invented by mortal man; it was the ideal humanism and most effectively removed all grounds for superstition, magical rituals, and fear of ghosts or demons. (1037.3) 94:8.19 The great weakness in the original gospel of Buddhism was that it did not produce a religion of unselfish social service. The Buddhistic brotherhood was, for a long time, not a fraternity of believers but rather a community of student teachers. Gautama forbade their receiving money and thereby sought to prevent the growth of hierarchal tendencies. Gautama himself was highly social; indeed, his life was much greater than his preachment. 9. The Spread of Buddhism (1037.4) 94:9.1 Buddhism prospered because it offered salvation through belief in the Buddha, the enlightened one. It was more representative of the Melchizedek truths than any other religious system to be found throughout eastern Asia. But Buddhism did not become widespread as a religion until it was espoused in self-protection by the low-caste monarch Asoka, who, next to Ikhnaton in Egypt, was one of the most remarkable civil rulers between Melchizedek and Michael. Asoka built a great Indian empire through the propaganda of his Buddhist missionaries. During a period of twenty-five years he trained and sent forth more than seventeen thousand missionaries to the farthest frontiers of all the known world. In one generation he made Buddhism the dominant religion of one half the world. It soon became established in Tibet, Kashmir, Ceylon, Burma, Java, Siam, Korea, China, and Japan. And generally speaking, it was a religion vastly superior to those which it supplanted or upstepped. (1037.5) 94:9.2 The spread of Buddhism from its homeland in India to all of Asia is one of the thrilling stories of the spiritual devotion and missionary persistence of sincere religionists. The teachers of Gautama’s gospel not only braved the perils of the overland caravan routes but faced the dangers of the China Seas as they pursued their mission over the Asiatic continent, bringing to all peoples the message of their faith. But this Buddhism was no longer the simple doctrine of Gautama; it was the miraculized gospel which made him a god. And the farther Buddhism spread from its highland home in India, the more unlike the teachings of Gautama it became, and the more like the religions it supplanted, it grew to be. (1038.1) 94:9.3 Buddhism, later on, was much affected by Taoism in China, Shinto in Japan, and Christianity in Tibet. After a thousand years, in India Buddhism simply withered and expired. It became Brahmanized and later abjectly surrendered to Islam, while throughout much of the rest of the Orient it degenerated into a ritual which Gautama Siddhartha would never have recognized. (1038.2) 94:9.4 In the south the fundamentalist stereotype of the teachings of Siddhartha persisted in Ceylon, Burma, and the Indo-China peninsula. This is the Hinayana division of Buddhism which clings to the early or asocial doctrine. (1038.3) 94:9.5 But even before the collapse in India, the Chinese and north Indian groups of Gautama’s followers had begun the development of the Mahayana teaching of the “Great Road” to salvation in contrast with the purists of the south who held to the Hinayana, or “Lesser Road.” And these Mahayanists cast loose from the social limitations inherent in the Buddhist doctrine, and ever since has this northern division of Buddhism continued to evolve in China and Japan. (1038.4) 94:9.6 Buddhism is a living, growing religion today because it succeeds in conserving many of the highest moral values of its adherents. It promotes calmness and self-control, augments serenity and happiness, and does much to prevent sorrow and mourning. Those who believe this philosophy live better lives than many who do not. 10. Religion in Tibet (1038.5) 94:10.1 In Tibet may be found the strangest association of the Melchizedek teachings combined with Buddhism, Hinduism, Taoism, and Christianity. When the Buddhist missionaries entered Tibet, they encountered a state of primitive savagery very similar to that which the early Christian missionaries found among the northern tribes of Europe. (1038.6) 94:10.2 These simple-minded Tibetans would not wholly give up their ancient magic and charms. Examination of the religious ceremonials of present-day Tibetan rituals reveals an overgrown brotherhood of priests with shaven heads who practice an elaborate ritual embracing bells, chants, incense, processionals, rosaries, images, charms, pictures, holy water, gorgeous vestments, and elaborate choirs. They have rigid dogmas and crystallized creeds, mystic rites and special fasts. Their hierarchy embraces monks, nuns, abbots, and the Grand Lama. They pray to angels, saints, a Holy Mother, and the gods. They practice confessions and believe in purgatory. Their monasteries are extensive and their cathedrals magnificent. They keep up an endless repetition of sacred rituals and believe that such ceremonials bestow salvation. Prayers are fastened to a wheel, and with its turning they believe the petitions become efficacious. Among no other people of modern times can be found the observance of so much from so many religions; and it is inevitable that such a cumulative liturgy would become inordinately cumbersome and intolerably burdensome. (1038.7) 94:10.3 The Tibetans have something of all the leading world religions except the simple teachings of the Jesusonian gospel: sonship with God, brotherhood with man, and ever-ascending citizenship in the eternal universe. 11. Buddhist Philosophy (1038.8) 94:11.1 Buddhism entered China in the first millennium after Christ, and it fitted well into the religious customs of the yellow race. In ancestor worship they had long prayed to the dead; now they could also pray for them. Buddhism soon amalgamated with the lingering ritualistic practices of disintegrating Taoism. This new synthetic religion with its temples of worship and definite religious ceremonial soon became the generally accepted cult of the peoples of China, Korea, and Japan. (1039.1) 94:11.2 While in some respects it is unfortunate that Buddhism was not carried to the world until after Gautama’s followers had so perverted the traditions and teachings of the cult as to make of him a divine being, nonetheless this myth of his human life, embellished as it was with a multitude of miracles, proved very appealing to the auditors of the northern or Mahayana gospel of Buddhism. (1039.2) 94:11.3 Some of his later followers taught that Sakyamuni Buddha’s spirit returned periodically to earth as a living Buddha, thus opening the way for an indefinite perpetuation of Buddha images, temples, rituals, and impostor “living Buddhas.” Thus did the religion of the great Indian protestant eventually find itself shackled with those very ceremonial practices and ritualistic incantations against which he had so fearlessly fought, and which he had so valiantly denounced. (1039.3) 94:11.4 The great advance made in Buddhist philosophy consisted in its comprehension of the relativity of all truth. Through the mechanism of this hypothesis Buddhists have been able to reconcile and correlate the divergencies within their own religious scriptures as well as the differences between their own and many others. It was taught that the small truth was for little minds, the large truth for great minds. (1039.4) 94:11.5 This philosophy also held that the Buddha (divine) nature resided in all men; that man, through his own endeavors, could attain to the realization of this inner divinity. And this teaching is one of the clearest presentations of the truth of the indwelling Adjusters ever to be made by a Urantian religion. (1039.5) 94:11.6 But a great limitation in the original gospel of Siddhartha, as it was interpreted by his followers, was that it attempted the complete liberation of the human self from all the limitations of the mortal nature by the technique of isolating the self from objective reality. True cosmic self-realization results from identification with cosmic reality and with the finite cosmos of energy, mind, and spirit, bounded by space and conditioned by time. (1039.6) 94:11.7 But though the ceremonies and outward observances of Buddhism became grossly contaminated with those of the lands to which it traveled, this degeneration was not altogether the case in the philosophical life of the great thinkers who, from time to time, embraced this system of thought and belief. Through more than two thousand years, many of the best minds of Asia have concentrated upon the problem of ascertaining absolute truth and the truth of the Absolute. (1039.7) 94:11.8 The evolution of a high concept of the Absolute was achieved through many channels of thought and by devious paths of reasoning. The upward ascent of this doctrine of infinity was not so clearly defined as was the evolution of the God concept in Hebrew theology. Nevertheless, there were certain broad levels which the minds of the Buddhists reached, tarried upon, and passed through on their way to the envisioning of the Primal Source of universes: (1039.8) 94:11.9 1. The Gautama legend. At the base of the concept was the historic fact of the life and teachings of Siddhartha, the prophet prince of India. This legend grew in myth as it traveled through the centuries and across the broad lands of Asia until it surpassed the status of the idea of Gautama as the enlightened one and began to take on additional attributes. (1040.1) 94:11.10 2. The many Buddhas. It was reasoned that, if Gautama had come to the peoples of India, then, in the remote past and in the remote future, the races of mankind must have been, and undoubtedly would be, blessed with other teachers of truth. This gave rise to the teaching that there were many Buddhas, an unlimited and infinite number, even that anyone could aspire to become one — to attain the divinity of a Buddha. (1040.2) 94:11.11 3. The Absolute Buddha. By the time the number of Buddhas was approaching infinity, it became necessary for the minds of those days to reunify this unwieldy concept. Accordingly it began to be taught that all Buddhas were but the manifestation of some higher essence, some Eternal One of infinite and unqualified existence, some Absolute Source of all reality. From here on, the Deity concept of Buddhism, in its highest form, becomes divorced from the human person of Gautama Siddhartha and casts off from the anthropomorphic limitations which have held it in leash. This final conception of the Buddha Eternal can well be identified as the Absolute, sometimes even as the infinite I AM. (1040.3) 94:11.12 While this idea of Absolute Deity never found great popular favor with the peoples of Asia, it did enable the intellectuals of these lands to unify their philosophy and to harmonize their cosmology. The concept of the Buddha Absolute is at times quasi-personal, at times wholly impersonal — even an infinite creative force. Such concepts, though helpful to philosophy, are not vital to religious development. Even an anthropomorphic Yahweh is of greater religious value than an infinitely remote Absolute of Buddhism or Brahmanism. (1040.4) 94:11.13 At times the Absolute was even thought of as contained within the infinite I AM. But these speculations were chill comfort to the hungry multitudes who craved to hear words of promise, to hear the simple gospel of Salem, that faith in God would assure divine favor and eternal survival. 12. The God Concept of Buddhism (1040.5) 94:12.1 The great weakness in the cosmology of Buddhism was twofold: its contamination with many of the superstitions of India and China and its sublimation of Gautama, first as the enlightened one, and then as the Eternal Buddha. Just as Christianity has suffered from the absorption of much erroneous human philosophy, so does Buddhism bear its human birthmark. But the teachings of Gautama have continued to evolve during the past two and one-half millenniums. The concept of Buddha, to an enlightened Buddhist, is no more the human personality of Gautama than the concept of Jehovah is identical with the spirit demon of Horeb to an enlightened Christian. Paucity of terminology, together with the sentimental retention of olden nomenclature, is often provocative of the failure to understand the true significance of the evolution of religious concepts. (1040.6) 94:12.2 Gradually the concept of God, as contrasted with the Absolute, began to appear in Buddhism. Its sources are back in the early days of this differentiation of the followers of the Lesser Road and the Greater Road. It was among the latter division of Buddhism that the dual conception of God and the Absolute finally matured. Step by step, century by century, the God concept has evolved until, with the teachings of Ryonin, Honen Shonin, and Shinran in Japan, this concept finally came to fruit in the belief in Amida Buddha. (1041.1) 94:12.3 Among these believers it is taught that the soul, upon experiencing death, may elect to enjoy a sojourn in Paradise prior to entering Nirvana, the ultimate of existence. It is proclaimed that this new salvation is attained by faith in the divine mercies and loving care of Amida, God of the Paradise in the west. In their philosophy, the Amidists hold to an Infinite Reality which is beyond all finite mortal comprehension; in their religion, they cling to faith in the all-merciful Amida, who so loves the world that he will not suffer one mortal who calls on his name in true faith and with a pure heart to fail in the attainment of the supernal happiness of Paradise. (1041.2) 94:12.4 The great strength of Buddhism is that its adherents are free to choose truth from all religions; such freedom of choice has seldom characterized a Urantian faith. In this respect the Shin sect of Japan has become one of the most progressive religious groups in the world; it has revived the ancient missionary spirit of Gautama’s followers and has begun to send teachers to other peoples. This willingness to appropriate truth from any and all sources is indeed a commendable tendency to appear among religious believers during the first half of the twentieth century after Christ. (1041.3) 94:12.5 Buddhism itself is undergoing a twentieth-century renaissance. Through contact with Christianity the social aspects of Buddhism have been greatly enhanced. The desire to learn has been rekindled in the hearts of the monk priests of the brotherhood, and the spread of education throughout this faith will be certainly provocative of new advances in religious evolution. (1041.4) 94:12.6 At the time of this writing, much of Asia rests its hope in Buddhism. Will this noble faith, that has so valiantly carried on through the dark ages of the past, once again receive the truth of expanded cosmic realities even as the disciples of the great teacher in India once listened to his proclamation of new truth? Will this ancient faith respond once more to the invigorating stimulus of the presentation of new concepts of God and the Absolute for which it has so long searched? (1041.5) 94:12.7 All Urantia is waiting for the proclamation of the ennobling message of Michael, unencumbered by the accumulated doctrines and dogmas of nineteen centuries of contact with the religions of evolutionary origin. The hour is striking for presenting to Buddhism, to Christianity, to Hinduism, even to the peoples of all faiths, not the gospel about Jesus, but the living, spiritual reality of the gospel of Jesus. (1041.6) 94:12.8 [Presented by a Melchizedek of Nebadon.]

Today's the day that Google unifies the big privacy policy in the sky. Now, your user history on one Google product will likely inform the results and performance of other Google products you use. For many, that's a good thing. For others, it's creepy. We also cover the Google bypassing user preferences for cookies thing, putting "don't be evil" in question. And, if you haven't read The Information Diet by Clay Johnson, do it. Quick. We talk all about why this week on the show. Finally, Pinterest. Are you Pinterested?