Podcasts about Hohl

Ich habe mal verschiedene alternative Anlageklassen unter die Lupe genommen – von Gold über Private Equity bis hin zu Kryptowährungen.  Mein Fazit erzähle ich Dir in der heutigen Folge. Du hast einen Themen-Wunsch für den Podcast oder interessierst Dich für ein Seminar mit mir? Schreibe mir gerne einfach per E-Mail: krapp@abatus-beratung.com Viel Spaß beim Hören, Dein Matthias Krapp (Transkript dieser Folge weiter unten)   NEU!!! Hier kannst Du Dich kostenlos für meinen Minikurs registrieren und reinschauen. Es lohnt sich: https://portal.abatus-beratung.com/geldanlage-kurs/    

We have published 120 episodes since 2019. For this new season, we thought we would look back on some of the highlights of our conversations and choose 20 episodes that resonated with veterans, service members, military families, and the civilians who support them.But first up, you'll hear from some of the folks at Home Base who wake up every day with the same mission in mind, no matter what they do at the Center of Excellence in the Navy Yard and beyond.Over the next twenty weeks, we will share these staff conversations I had with some of the hard-working professionals at Home Base who help treat the invisible wounds of veterans and military families.For this episode, you will hear a brief conversation with Home Base Marine Veteran Alexander Hohl, Licensed Mental Health Counselor, followed by one of the earlier episodes, in which Ron sat with the US Army Colonel and Combat Surgeon Dr. David King and Red Sox legend David "Big Papi" Ortiz.  Boston just celebrated the 250th anniversary of the American Revolution, and we felt it a good time to re-share the episode that remembers the Boston Marathon bombing and the inspiration Big Papi brought to the city during that time.Many thanks to Alexander Hohl for all his work at Home Base to support this mission to stomp stigma and treat the invisible wounds of veterans and military families.Run To Home Base: Join Ron and his team and sign up individually or on another team at the 16th annual Run To Home Base on July 26th, 2025, at Fenway Park! Go to runtohomebase.orgPlease go to homebase.org for updates, programming, and resources if you or anyone you know is struggling. Home Base Nation is the official podcast for the Home Base Program for Veterans and Military Families. Our team sees veterans, service members, and their families addressing the invisible wounds of war at no cost. This is all made possible thanks to a grateful nation. If you want to learn more about how you can help, visit us at www.homebase.org. If you or anyone you know would like to connect to care, you can also reach us at 617-724-5202.Follow Home Base on Twitter, Facebook, Instagram, LinkedInThe Home Base Nation Team is Steve Monaco, Army Veteran Kelly Field, Justin Scheinert, Chuck Clough, with COO Michael Allard, Brigadier General Jack Hammond, and Peter Smyth.Producer and Host: Dr. Ron HirschbergAssistant Producer, Editor: Chuck CloughChairman, Home Base Media Lab: Peter SmythThe views expressed by guests on the Home Base Nation podcast are their own, and their appearance on the program does not imply an endorsement of them or any entity they represent. Views and opinions expressed by guests are those of the guests and do not necessarily reflect the views of the Massachusetts General Hospital, Home Base, the Red Sox Foundation, or any of its officials.

Send us a textIn the bonus episode, Beth, Brittany, and Stephanie sit down with the current ALA President, Cindy Hohl, to discuss National Library Week and the upcoming ALA Annual Conference & Exhibition.Click here to learn more about the ALA Annual.

You're listening to Voices of Your Village. And today I get to hang out with Stefanie Hohl, who has a master's in education and has been teaching children to read for years. She holds advanced degrees in both children's literature and early education, and she has experience running preschool, homeschool, and local storytime programs. Stefanie developed the ABC: See, Hear, Do, Learn to Read method to make early reading fun and easy for kids and their parents. Stefanie lives in Pittsburgh with her husband, five children, and two very silly dogs. I really enjoyed this conversation because I don't know a lot about teaching kids to read. And I do know that what doesn't feel good for me is being like, sit down, do this worksheet. I know that my son who loves movement doesn't retain information this way. So I was really excited to learn from Stefanie and have personally purchased some of her materials because I'm really enjoying them. I love how she incorporates movement with reading. And I feel like I just get the best bang for my buck in terms of the time spent with my tiny human working on these skills. All right, folks, let's dive in.  Connect with Stefanie: Instagram: @abcseeheardo, @stefaniehohl Website: www.abcseeheardo.com Order the books: ABC See Hear Do Connect with us: Instagram: @seed.and.sew  Podcast page: Voices of Your Village Seed and Sew's Regulation Quiz: Take the Quiz Order Tiny Humans, Big Emotions now!  Website: seedandsew.org Music by: Ruby Adams and Bensound Learn more about your ad choices. Visit megaphone.fm/adchoices

In this episode of the Business of Architecture podcast, Rion Willard dives into the fascinating intersection of fashion, personal branding, and business success with tailor and stylist Victoria from Klein Epstein Parker. Victoria shares her journey into bespoke tailoring, revealing surprising challenges and unexpected collaborations that helped her business thrive. Together, they explore why what you wear says so much about who you are and how it can impact your confidence, career, and even the perception of your leadership. Discover how a bold outfit can transform your mindset and command respect, and why some style choices make a bigger statement than others. Victoria also touches on a major cultural difference in dressing well and how it reflects values of respect and professionalism. Why a single outfit can change how people see you—and how you see yourself. The secret power behind dressing like a leader. A fascinating story about a basketball team using fashion to gain an edge. The surprising way personal style connects to fast fashion and sustainability.   To learn more about Victoria, visit her: Website: https://kleinepsteinparker.com/ Instagram: https://www.instagram.com/kleinepsteinparker/ TikTok: https://www.tiktok.com/@kleinepsteinparker Facebook: https://www.facebook.com/Kleinepsteinparker Twitter: https://twitter.com/KEPRebels Pinterest: https://www.pinterest.com/kleinepsteinparker/ LinkedIn: https://www.linkedin.com/company/kleinepsteinparker/   ► Transcription: https://otter.ai/u/CWJ-iprr4Qe6Qvo0E8SMihfUpk0?utm_source=copy_url   ► Feedback? Email us at podcast@businessofarchitecture.com   ► Access your free training at http://SmartPracticeMethod.com/   ► If you want to speak directly to our advisors, book a call at https://www.businessofarchitecture.com/call   ► Subscribe to our YouTube Channel for updates:   https://www.youtube.com/c/BusinessofArchitecture   *******   For more free tools and resources for running a profitable, impactful, and fulfilling practice, connect with me on: Facebook: https://www.facebook.com/groups/businessofarchitecture Instagram: https://www.instagram.com/businessofarch/ Website: https://www.businessofarchitecture.com/yt Twitter: https://twitter.com/BusinessofArch Podcast: http://www.businessofarchitecture.com/show iTunes: https://podcasts.apple.com/us/podcast/business-architecture-podcast/id588987926 Android Podcast Feed: http://feeds.feedburner.com/BusinessofArchitecture-podcast Google Podcasts: https://podcasts.google.com/feed/aHR0cHM6Ly9idXNpbmVzc29mYXJjaGl0ZWN0dXJlLmxpYnN5bi5jb20vcnNz   *******   Access the FREE Architecture Firm Profit Map video here: http://freearchitectgift.com   Carpe Diem!

Bud Hohl and Billy Whitford have been part of the Outrigger Paddling world since the 60's; and they haven't stopped. Bud is a walking encyclopedia of paddling history, trivia, names, dates and details with a long history of making canoes, paddles and everything else in the sport. These two continue to provide leadership, support, race organization, humor and history. Today they are dedicated to gathering and preserving this history so it lives on. This interview is part of that mission.

As the final episode in the three-part special Esri takeover series on the Energy Central Power Perspectives Podcast, Pat Hohl and Bill Meehan-- Directors at Esri-- bring their conversation to a conclusion by focusing on two essential areas: enterprise access and collaboration, as well as the essential (and sometime frustrating) areas of data quality and governance. Pat and Bill will bring their experience to the listener in breaking down silos and improving communication across departments are critical for utility success. They share real-life examples from their experiences, like the consequences of hoarding information and how modern tools and technologies can foster collaboration both within companies and with external stakeholders such as regulators. Listen in as this episode also touches on the role of effective data governance in ensuring data quality, discussing the importance of maintaining high accuracy and ensuring data integrity across systems. Pat and Bill explore the exciting innovations and technologies currently taking hold in the sector to automate and streamline these processes, reducing the burden on employees and allowing utilities to focus on delivering efficient, reliable services. Given how enterprise access and data quality governance are key to running a successful, modern utility, you won't want to miss this discussion. Key Links: Energy Central Post with Full Episode Transcript: https://energycentral.com/o/energy-central/episode-182-access-collaboration-and-data-quality-keys-modern-utility-pat-hohl Episode 1 of this three-part series, "Episode #178: "Breaking Boundaries: Cross-Industry Innovation at IMGIS 2024" with Pat Hohl and Bill Meehan, Directors at ESRI [Special Energy Central Power Perspectives™ Podcast Presented by ESRI]": https://energycentral.com/c/iu/episode-178-breaking-boundaries-cross-industry-innovation-imgis-2024-pat-hohl-and Episode 2: "Episode #181: "Breaking Down Silos with GIS and Advanced Modeling in the Utility Sector" with Pat Hohl and Bill Meehan, Directors at ESRI [Special Energy Central Power Perspectives™ Podcast Presented by ESRI]": https://energycentral.com/o/energy-central/episode-181-breaking-down-silos-gis-and-advanced-modeling-utility-sector-pat-hohl GIS for Electric Utilities from ESRI: https://www.esri.com/en-us/industries/electric/overview Ask a Question to Our Future Guests: Do you have a burning question for the utility executives and energy industry thought leaders that we feature each week on the Energy Central Power Perspectives Podcast? Do you want to hear your voice on a future episode? Well starting in 2024, we're offering you that opportunity! Head to this link where you can leave us a recorded message, including a question you're eager to have answered on a future episode of the podcast. We'll listen through them, pick out the right guests in our upcoming lineup to address them, and you'll hear yourself as a part of the conversation! Energy Central on SpeakPipe: www.speakpipe.com/EnergyCentralPodcast

Continuing the Esri takeover series of the Energy Central Power Perspectives Podcast, Bill Meehan and Pat Hohl, both Directors at Esri, use episode two of this three-part series to share insights in the rapidly changing world of utility network management. Pat and Bill share with listeners their views on how utilities are modernizing their systems to meet the challenges of an evolving energy landscape. As utilities face increasing demands from distributed energy resources (DERs), network expansions, and electrification of transportation, the need for accurate, real-time data becomes more critical than ever. In that light, this conversation covers how utilities are embracing new technologies like Advanced Distribution Management Systems (ADMS) and Distributed Energy Resource Management Systems (DERMS), and why the quality and governance of network data is at the heart of it all. Listen in to get a deep dive into key topics like network modeling, the role of geospatial systems and GIS in improving data integration, and the necessity of creating a single source of truth for utility operations. This episode is packed with practical insights and real-world examples, plus the discussion teases upcoming topics such as enterprise data access and the future of AI in utility management, offering a compelling reason to tune in to future episodes. Key Links: Energy Central Post with Full Episode Transcript: https://energycentral.com/o/energy-central/episode-181-breaking-down-silos-gis-and-advanced-modeling-utility-sector-pat-hohl Episode 1 of this three-part series, "Episode #178: "Breaking Boundaries: Cross-Industry Innovation at IMGIS 2024" with Pat Hohl and Bill Meehan, Directors at ESRI [Special Energy Central Power Perspectives™ Podcast Presented by ESRI]": https://energycentral.com/c/iu/episode-178-breaking-boundaries-cross-industry-innovation-imgis-2024-pat-hohl-and Other previous podcast appearances from Pat and Bill Episode #10: ‘The Past & Future of Circuits & How GIS is Transforming the Grid, COVID-19 Response, & More' with Pat Hohl of Esri - [an Energy Central Power Perspectives™ Podcast]: https://energycentral.com/c/iu/energy-central-power-perspectives%E2%84%A2-podcast-episode-10-%E2%80%98-past-future-circuits-how  Episode #12: ‘To Unlock the Modern Utility, GIS is Key' with Bill Meehan of Esri - [an Energy Central Power Perspectives™ Podcast]: https://energycentral.com/c/iu/energy-central-power-perspectives%E2%84%A2-podcast-episode-12-%E2%80%98-unlock-modern-utility-gis Episode #47: GIS, Digital Twin, and the Intelligent Reality of Utilities Today with Pat Hohl and Bill Meehan of Esri [an Energy Central Power Perspectives™ Podcast]: https://energycentral.com/o/energy-central/special-edition-gis-digital-twin-and-intelligent-reality-utilities-today-pat-hohl Episode #80: 'Taking a Geographic Approach to Public Grid Investment' with Bill Meehan and Pat Hohl of Esri [an Energy Central Power Perspectives™ Podcast]: https://energycentral.com/o/energy-central/episode-80-taking-geographic-approach-public-grid-investment-bill-meehan-and-pat Episode #95: 'Debating Utilities' Role In Transportation Electrification' With Esri's Bill Meehan & Pat Hohl [an Energy Central Power Perspectives™ Podcast]: https://energycentral.com/o/energy-central/episode-95-debating-utilities-role-transportation-electrification-esris-bill Episode 131: 'Unlocking the Power of GIS: Sharing, Understanding, and Capturing Utility Data': https://energycentral.com/o/esri/special-episode-unlocking-power-gis-sharing-understanding-and-capturing-utility Episode 132: 'Harnessing GIS for Strategic Utility Insight': https://energycentral.com/o/energy-central/special-episode-harnessing-gis-strategic-utility-insight-pat-hohl-and-bill-meehan Episode 133: 'The Role of GIS Data, Mobility, and Digital Twins': https://energycentral.com/c/iu/special-episode-role-gis-data-mobility-and-digital-twins-pat-hohl-and-bill-meehan

In July 2024, Cindy Hohl was inaugurated as the next President of the American Library Association (ALA). As a member of the Santee Sioux Nation in Nebraska, she is the second Native American woman to serve as ALA President. During her term, she plans to focus on four main pillars of librarianship: intellectual freedom, literacy, learning, and leadership. "There has never been a better time to serve our communities within the roles of librarianship and we stand united in our mission to ensure equal access to information for all," said Hohl.rnrnHohl also plans to lead the creation of an informational toolkit to address Missing, Murdered, Indigenous Women and People in the United States when communities need information to conduct searches for their missing loved ones, or to share information outside of the community.rnrnIn partnership with Cleveland Public Library, and in honor of Indigenous Peoples' Day, the City Club's Cynthia Connolly will sit down with Cindy Hohl to discuss the crucial role of libraries in fostering a sense of civic responsibility through diverse representation and community engagement.

Cindy Hohl, the current president of the American Library Association, says the political temperature surrounding book bans has remained at a boiling point. Over the last year of her tenure, Hohl has witnessed librarians exit the profession due to increased stress, ridicule and public pressure to remove certain titles from their libraries–particularly those related to race and LGBTQ+ identity. Although these battles are particularly pronounced in hot spots like Florida and Texas, they're being fought in communities all over the country. In today's episode, NPR's Andrew Limbong speaks with Hohl about what librarians can and can't do to push back against this cycle of censorship and what it's like to lead through times of crisis.To listen to Book of the Day sponsor-free and support NPR's book coverage, sign up for Book of the Day+ at plus.npr.org/bookofthedayLearn more about sponsor message choices: podcastchoices.com/adchoicesNPR Privacy Policy

Are you trying to teach your child to read? Learn how using movement activities will make learning to read easy and fun. This episode will explain just the right strategy if you have a kid who can't sit still - but still needs to learn to read! Our guest is educator and author Stefanie Hohl. Show notes are at https://www.4onemore.com/284 --- Support this podcast: https://podcasters.spotify.com/pod/show/homeschoolwithmoxie/support

Nebraska needs to just go with what they have right now at kicker.

As a departure from the usual format on the Energy Central Power Perspectives Podcast, this episode features an exclusive guest-led conversation with two of the most familiar voices in the Energy Central community: Bill Meehan and Pat Hohl, both Directors at Esri. In this episode, Bill and Pat dive deep into the themes and insights to be explored at the upcoming IMGIS Conference, set to take place this upcoming October. Throughout this engaging discussion, they focus on how innovation in infrastructure management is unlocking the potential of Geographic Information Systems (GIS) across industries. From emergency management to AI-driven imagery to digital transformation, Bill and Pat highlight the key takeaways for professionals across the utility sector. Listen in as they explore cross-industry solutions, the power of GIS in utilities, and how new technology can revolutionize day-to-day tasks. Key Links: Energy Central Post with Full Episode Transcript: https://energycentral.com/c/iu/episode-178-breaking-boundaries-cross-industry-innovation-imgis-2024-pat-hohl-and IMGIS 2024: https://www.esri.com/en-us/about/events/imgis/overview?gclid=Cj0KCQjwrp-3BhDgARIsAEWJ6SwzbfdnssNJaysBR7e4atYSfdrHDIVJruNKthlBJAU9TzEB31J4tTMaAqsSEALw_wcB&aduc=Advertising&sf_id=7015x000000j2zTAAQ&adut=ppcbrand&aduco=value&aduca=EIMGIS24&utm_id=7015x000000j2zTAAQ&adum=PPC&utm_campaign=EIMGIS24&adusf=Google&utm_term=ppcbrand&utm_source=Advertising&utm_medium=PPC&utm_content=value&ef_id=Cj0KCQjwrp-3BhDgARIsAEWJ6SwzbfdnssNJaysBR7e4atYSfdrHDIVJruNKthlBJAU9TzEB31J4tTMaAqsSEALw_wcB:G:s&s_kwcid=AL!8948!3!712522044695!p!!g!!imgis%20conference&_bk=imgis%20conference&_bt=712522044695&_bm=p&_bn=g&_bg=170071504474&aducop=imgis%20conference-p&gclsrc=aw.ds&gad_source=1 Episode #10: ‘The Past & Future of Circuits & How GIS is Transforming the Grid, COVID-19 Response, & More' with Pat Hohl of Esri - [an Energy Central Power Perspectives™ Podcast]: https://energycentral.com/c/iu/energy-central-power-perspectives%E2%84%A2-podcast-episode-10-%E2%80%98-past-future-circuits-how  Episode #12: ‘To Unlock the Modern Utility, GIS is Key' with Bill Meehan of Esri - [an Energy Central Power Perspectives™ Podcast]: https://energycentral.com/c/iu/energy-central-power-perspectives%E2%84%A2-podcast-episode-12-%E2%80%98-unlock-modern-utility-gis Episode #47: GIS, Digital Twin, and the Intelligent Reality of Utilities Today with Pat Hohl and Bill Meehan of Esri [an Energy Central Power Perspectives™ Podcast]: https://energycentral.com/o/energy-central/special-edition-gis-digital-twin-and-intelligent-reality-utilities-today-pat-hohl Episode #80: 'Taking a Geographic Approach to Public Grid Investment' with Bill Meehan and Pat Hohl of Esri [an Energy Central Power Perspectives™ Podcast]: https://energycentral.com/o/energy-central/episode-80-taking-geographic-approach-public-grid-investment-bill-meehan-and-pat Episode #95: 'Debating Utilities' Role In Transportation Electrification' With Esri's Bill Meehan & Pat Hohl [an Energy Central Power Perspectives™ Podcast]: https://energycentral.com/o/energy-central/episode-95-debating-utilities-role-transportation-electrification-esris-bill Episode 131: 'Unlocking the Power of GIS: Sharing, Understanding, and Capturing Utility Data': https://energycentral.com/o/esri/special-episode-unlocking-power-gis-sharing-understanding-and-capturing-utility Episode 132: 'Harnessing GIS for Strategic Utility Insight': https://energycentral.com/o/energy-central/special-episode-harnessing-gis-strategic-utility-insight-pat-hohl-and-bill-meehan Episode 133: 'The Role of GIS Data, Mobility, and Digital Twins': https://energycentral.com/c/iu/special-episode-role-gis-data-mobility-and-digital-twins-pat-hohl-and-bill-meehan Pat Hohl's Energy Central Profile: energycentral.com/member/profile/204983/about Bill Meehan's Energy Central Profile: https://energycentral.com/member/profile/360/about

Da muss doch mehr sein als nur graue Substanz: Frank und Moritz sind in dieser Folge als Hirnhöhlenforscher unterwegs und bereisen die vier Hirnventrikel. Dabei erfahrt ihr, weshalb es sich dabei keineswegs nur um Hohlräume, sondern auch Funktionsräume handelt, wie der Liquor gebildet wird und welche Besonderheit der dritte Hirnventrikel aufweist. Übrigens: Schickt uns eure Fragen und euer Feedback zum Podcast gerne an: podcast@doccheck.com

Stefanie Hohl, M.Ed., has been teaching children to read for years. She holds advanced degrees in both children's literature and early childhood education, and she has experience running preschool, homeschool, and local storytime programs. Stefanie developed the ABC See, Hear, Do Learn-to-Read method to make early reading fun and easy for kids and their parents. Stefanie lives in Pittsburgh with her husband, five children, two very silly dogs and two cuddly cats. The program combines visual, auditory, and kinesthetic learning styles and has shown to increase learning and retention by 90%. In this episode, Stefanie also shares her journey of developing a parent-friendly reading method and emphasizes the benefits of incorporating movement into learning. Stefanie emphasizes the importance of building a strong foundation in phonics before third grade to prevent kids from falling behind and struggling in school, as reading is essential for learning across subjects. The research shows phonics is the best way for kids to learn reading, though many schools have abandoned this approach, leading to an alarming percentage of students not being at grade level. Stefanie's program consists of seven levels designed to make learning fun through games, activities, and books that teach letter sounds and different phonics patterns in a multisensory way. We discuss the importance of parents selecting age-appropriate early readers for their children and the early signs of reading disabilities. Stefanie also shares details about her Christmas-themed books and her journey from her master's in education to becoming a writer. Enjoy the show! The earliest reader for pre-readers board book here: https://www.abcseeheardo.com/board-books/my-first-abc-sounds Find Stefanie here: https://www.stefaniehohl.com/ https://www.abcseeheardo.com/ Instagram, FB, X, TikTok - @stefaniehohl and @abcseeheardo ABC See, Hear, Do Level 1: Learn to Read Uppercase Letters (https://amzn.to/45OI0Px) Her Christmas book here  Please like and subscribe to our podcast and leave a 5-star review so we can reach more parents like you! Subscribe to our podcast by sending an email to subscribe@teachingyourtoddler.com  For more expert interviews, fun activities and story time podcasts, please visit our website at TeachingYourToddler.com Check us out on Facebook at Teaching Your Toddler and on twitter at @TeachingToddler and on Instagram at @teachingyourtoddler  To support great future content, please click here and help us out with a $5 gift: glow.fm/teachingyourtoddler Leave us some feedback on this show and your ideas for future shows! #parenting #toddlers #moms #momlife #kids #podcast #toddlerlife 

In dieser fesselnden Podcast-Folge habe ich einen besonderen Gast: Frau Dr. Karma Hohl, eine erfahrene Anwältin, die sich unter anderem auf das Apothekenrecht spezialisiert hat. Gemeinsam tauchen wir in die faszinierende Welt der Apotheken ein und sprechen über den Traum, eine eigene Apotheke zu besitzen. Dr Hohl gibt uns wertvolle Einblicke in die rechtlichen Aspekte und Herausforderungen, die mit dem Aufbau und Betrieb einer Apotheke verbunden sind. Wir erfahren mehr über die Voraussetzungen, die erfüllt werden müssen, um eine Apotheke zu eröffnen, und wie man mit den regulatorischen Anforderungen umgeht. Du erfahrst welche Schritte unternommen werden können, um den Traum von der eigenen Apotheke erfolgreich zu verwirklichen. Egal, ob du selbst den Wunsch hast, eine Apotheke zu gründen, oder einfach nur neugierig bist und mehr über das Apothekenrecht erfahren möchtest, diese Podcast-Folge bietet eine fesselnde und informative Unterhaltung. Also setz dich bequem hin, lehn dich zurück und genieße diese inspirierende Episode, in der wir gemeinsam den Traum der eigenen Apotheke erkunden.

Manchmal kann man Glück und Können relativ leicht voneinander unterscheiden, manchmal nicht. Nehmen wir mal an, jemand sagt 20 Münzwürfe hintereinander richtig voraus. Ist das jetzt Glück oder Können? Glück, da sind wir uns wohl alle einig.  Wenn ein Dart-Champion 180 Punkte wirft? Dann würden wir wahrscheinlich sagen, dass dies das Ergebnis von Können und unzähligen Stunden Training ist.  Die richtige Zahl am Roulettetisch? Glück.  Wenn ich bei meinem Golfspiel den Ball direkt vom Abschlag weg einloche? Glück. Bei Tiger Woods? Ein bisschen Glück, ja, aber Tiger Woods schafft es immer wieder, in die Nähe des Lochs zu kommen. Und wie ist es im Fondsmanagement? Angenommen, ein Fondsmanager ist sehr erfolgreich. Liegt es dann daran, dass er sich immer im richtigen Moment konträr zum Markt verhält? Mehr dazu im heutigem Podcast. Viel Spaß beim Hören,Dein Matthias Krapp(Transkript dieser Folge weiter unten) NEU!!! Hier kannst Du Dich kostenlos für meinen Minikurs registrieren und reinschauen. Es lohnt sich: https://portal.abatus-beratung.com/geldanlage-kurs/   

Connor & Brian are back, and they are joined by Garret Hohl of “The Five Hohl” to discuss the Jets first round matchup against the Colorado Avalanche, their six-game winning streak, and much more!!All that & more on Ep. 84 of the LFP! Make sure you join us on Thursday for Ep. 85!!This episode of the Level Flight podcast is presented by Draft Kings - Use Promo Code THPN at sign-up for exclusive offers at https://tinyurl.com/DRAFTKINGSPROMOTHPN The Level Flight Podcast is a proud member of The Hockey Podcast Network.Join us on Tuesdays and Thursdays for brand-new episodes! Don't forget to join us every Sunday morning at 9AM CT for LFP Live on our YouTube channel.Subscribe: Rate & review on Apple Podcasts and Spotify!Looking for the video pod? Like and Subscribe on YouTube!Follow us on Twitter, Facebook, TikTok, and Instagram at @LevelFlightWPGAll links: https://linktr.ee/levelflightwpg/Follow Brian on Twitter: @YWGBrianFollow Connor on Twitter: @ConnorHrabchak1Follow Elliott on Twitter: @ElliottRussenh1Go Jets!#GoJetsGoLearn more about your ad choices. Visit megaphone.fm/adchoices

Connor & Brian are back, and they are joined by Garret Hohl of “The Five Hohl” to discuss the Jets first round matchup against the Colorado Avalanche, their six-game winning streak, and much more!! All that & more on Ep. 84 of the LFP! Make sure you join us on Thursday for Ep. 85!! This episode of the Level Flight podcast is presented by Draft Kings - Use Promo Code THPN at sign-up for exclusive offers at https://tinyurl.com/DRAFTKINGSPROMOTHPN  The Level Flight Podcast is a proud member of The Hockey Podcast Network. Join us on Tuesdays and Thursdays for brand-new episodes! Don't forget to join us every Sunday morning at 9AM CT for LFP Live on our YouTube channel. Subscribe:  Rate & review on Apple Podcasts and Spotify! Looking for the video pod? Like and Subscribe on YouTube! Follow us on Twitter, Facebook, TikTok, and Instagram at @LevelFlightWPG All links: https://linktr.ee/levelflightwpg/ Follow Brian on Twitter: @YWGBrian Follow Connor on Twitter: @ConnorHrabchak1 Follow Elliott on Twitter: @ElliottRussenh1 Go Jets! #GoJetsGo Learn more about your ad choices. Visit megaphone.fm/adchoices Learn more about your ad choices. Visit megaphone.fm/adchoices

Brandon and Tyson are joined by Garret Hohl to talk Jets lines going into playoffs, a potential Jets/Avs playoff matchup and much more! Check out Garret Hohl at the Five Hohl Substack: https://thefivehohl.substack.com/ Learn more about your ad choices. Visit megaphone.fm/adchoices

Brandon and Tyson are joined by Garret Hohl to talk Jets lines going into playoffs, a potential Jets/Avs playoff matchup and much more!Check out Garret Hohl at the Five Hohl Substack:https://thefivehohl.substack.com/

Hat Taylor Swift jetzt eigentlich den Super Bowl gewonnen? Zumindest reden alle nur von ihr. Aber ist ja auch klar, denn die Popsängerin wird ja auch die nächste US-Präsidentin. Oder ist das doch alles nur wieder ein Verschwörungsmythos? Antworten darauf gibt es in der NDR Satire Intensiv-Station. Donald Trump und Joe Biden jedenfalls tragen lieber den Wettkampf, wer von beiden der Senilere ist, in einer Sonderausgabe von "Schlag den Star" aus. Außerdem guckt Moderator Torben Pöhls auf die sinkenden Umfragewerte der AfD und die überraschenden Avancen von CDU-Chef Friedrich Merz gegenüber den Grünen. Was wohl die Außenministerin Annalena Baerbock dazu sagt? Man muss ja so vieles neu denken, jetzt wo man das 1,5 Grad Ziel schon vorzeitig erreicht hat und bald auch in der Lüneburger Heide Karibik-Feeling aufkommt. Neu denken tut auch die "Letzte Generation". Sie will jetzt bei der Europawahl antreten und einige Passanten werden bestimmt an ihren Wahlkampfständen kleben bleiben. Neues Denken fordert auch die Tierschutzorganisation PETA. Schließlich ist das Karussellfahren auf Elefanten und Bären ja wohl völlig aus der Zeit gefallen. Und auch beim Karneval in Köln werden ganz neue Wege beschritten. Nur Putin ist noch ganz der Alte - auch wenn er endlich mal wieder ein langes Interview gegeben hat. In dieser Ausgabe der Intensiv-Station sind folgende Musiktitel zu hören: Teddy Swims – Cruel Summer (Taylor Swift Cover) Florian Wagner – AfD Postmodern Jukebox – Call me maybe (Carly Rae Jepsen Cover) Raum 27 – Das Klima wieder hin Rainald Grebe – Urlaub in Deutschland Mylie Cyrus – Wild Horses (Rolling Stones Cover) Peter Maffay - Alkohol (Herbert Grönemeyer Cover) Tom Butwin – Fly like an eagle (Steve Miller Band Cover) Hape Kerkeling - Das ganze Leben ist ein Quiz The Company - Always Look On The Bright Side of Life Unser Podcast-Tipp: extra 3 - Bosettis Woche ist endlich wieder aus der Winterpause zurück! https://www.ardaudiothek.de/sendung/extra-3-bosettis-woche/10358817/

In our first episode, we unpack what coercive control actually is, how we can really understand it, and why it matters.  To help us we welcome our special guest Dr Lindsay Kelland. Lindsay is a feminist philosopher based in the Allan Gray Centre for Leadership Ethics, Rhodes University (South Africa) where her research covers gender, sexualities, and sexual violence. To find out more about Lindsay's work click here. We also hear from members of the VAMHN Lived Experience Advisory Group (LEAG) and our LEAG Coordinator Lisa Ward. To find out more about the VAMHN LEAG click here. You can click the links below to access some of the resources we talk about in this episode, as well as some additional resources from our guest: Resources:  The paper we discuss in the episode containing the 13-item subscale on coercive control: Dutton, Mary Ann., Goodman, L., Schmidt, R.J. (2006). Development and Validation of a Coercive Control Measure for Intimate Partner Violence: Final Technical Report. Click here to access: ⁠https://www.ojp.gov/pdffiles1/nij/grants/214438.pdf⁠  Books: Evan Stark (2012) Looking Beyond Domestic Violence: Policing Coercive Control, Journal of Police Crisis Negotiations, 12:2, 199-217, ⁠DOI: 10.1080/15332586.2012.725016 Academic Papers: Anderson, K. L. (2009). Gendering Coercive Control. Violence Against Women, 15(12), 1444-1457. https://doi.org/10.1177/1077801209346837 Beck, C.J.A. and Raghavan, C. (2010), Intimate Partner Abuse Screening In Custody Mediation: The Importance Of Assessing Coercive Control. Family Court Review, 48: 555-565. Click here to access: https://onlinelibrary.wiley.com/doi/abs/10.1111/j.1744-1617.2010.01329.x  Crossman, K. A., Hardesty, J. L., & Raffaelli, M. (2016). “He Could Scare Me Without Laying a Hand on Me”: Mothers' Experiences of Nonviolent Coercive Control During Marriage and After Separation. Violence Against Women, 22(4), 454-473. Click here to access: https://journals.sagepub.com/doi/abs/10.1177/1077801215604744  Hardesty, J.L., Crossman, K.A., Haselschwerdt, M.L., Raffaelli, M., Ogolsky, B.G. and Johnson, M.P. (2015), Toward a Standard Approach to Operationalizing Coercive Control and Classifying Violence Types. Fam Relat, 77: 833-843. Click here to access: https://onlinelibrary.wiley.com/doi/abs/10.1111/jomf.12201 Myhill, A., & Hohl, K. (2019). The “Golden Thread”: Coercive Control and Risk Assessment for Domestic Violence. Journal of Interpersonal Violence, 34(21-22), 4477-4497. https://doi.org/10.1177/0886260516675464 Stark, E., & Hester, M. (2019). Coercive Control: Update and Review. Violence Against Women, 25(1), 81-104. Click here to access: https://journals.sagepub.com/doi/10.1177/1077801218816191  Tanha, M., Beck, C. J. A., Figueredo, A. J., & Raghavan, C. (2010). Sex Differences in Intimate Partner Violence and the Use of Coercive Control as a Motivational Factor for Intimate Partner Violence. Journal of Interpersonal Violence, 25(10), 1836-1854. Click here to access: https://journals.sagepub.com/doi/abs/10.1177/0886260509354501

Alex and Chace are back with a busy week of news in the NHL! To start, they take a look at the William Nylander contract that was announced this week and break down why it is surprisingly one they dislike, despite both really liking the player. From there, they shift to the Philadelphia Flyers trading Cutter Gauthier and what it means for both teams involved. As well as the drama that followed after the trade happened. They quickly look at Nick Foligno signing with the Chicago Blackhawks before Garret Hohl joins the show! Garret covers everything Winnipeg Jets with the guys. Looking at what has changed to cause such a successful season in Winnipeg. As well as breaking down some known and unsung heroes on the team.

Meet Dani Hohl — one of four new coaches on the Forward Focused team.  If you're intimidated by the idea of coaching, this interview is a great way to learn more. Dani's inspiring story will help you understand the power of coaching and how it can transform every aspect of your life, no matter where you are in your journey.  The 7 Circles Episode: https://www.youtube.com/watch?v=wxySwP5LaLE The 7 Circles Action Plan: https://getforwardfocused.com/the-7-circles-part-2/ ____ Subscribe to Forward Focused on YouTube,  Spotify (https://open.spotify.com/show/3LSwINv...) or Apple Podcasts (https://podcasts.apple.com/us/podcast...) to be notified as new episodes are released.  Connect with Forward Focused & Jon Ruesch at Website (https://www.getforwardfocused.com) Instagram (https://www.instagram.com/getforwardfocused) LinkedIn (https://www.linkedin.com/in/jon-reusc...) --- Send in a voice message: https://podcasters.spotify.com/pod/show/get-forward-focused/message

Gutzeit, Angelawww.deutschlandfunk.de, Büchermarkt

Débat entre Gabriela Kämpf, conseillère municipale à Vevey, en charge notamment de la coordination des manifestations et de la durabilité, et Frédéric Hohl, directeur d'une agence événementielle et ancien directeur exécutif de la Fête des Vignerons 2019.

Merriam-Webster's Word of the Day for October 22, 2023 is: beholden • bih-HOHL-dun • adjective Beholden is a formal adjective that describes someone as having obligations to someone or something else, often (but not always) to return a favor or gift. Beholden is usually followed by to. // She works for herself, and so is beholden to no one. // Many believe the government is overfull with politicians who are beholden to special interest groups. See the entry > Examples: “We are living through an information revolution. The traditional gatekeepers of knowledge—librarians, journalists and government officials—have largely been replaced by technological gatekeepers—search engines, artificial intelligence chatbots and social media feeds. Whatever their flaws, the old gatekeepers were, at least on paper, beholden to the public. The new gatekeepers are fundamentally beholden only to profit and to their shareholders. That is about to change, thanks to a bold experiment by the European Union.” — Julia Angwin, The New York Times, 14 July 2023 Did you know? To behold something is to perceive or gaze upon it—therefore, to be beholden is to be seen or observed, right? Not so fast! It's true that behold and beholden share the same Old English roots, and also that beholden originated as the past participle of behold, whose original meaning was “to hold or retain.” But the two words weaved and wended their way down different paths into present-day English. Behold had settled into its “perceive, see” use by the 12th century. Meanwhile, beholden was called into duty as the “indebted, obligated” adjective we know today by the 14th century, as evidenced by its appearance in the Middle-English poem Sir Gawain and the Green Knight. In the ensuing years, beholden has continued to describe people who are obligated to others (often for a favor or gift), as well as people or things that are in figurative debt due to aid or inspiration, as in “many contemporary books and films are beholden to old Arthurian legends.”

Es gibt nur Mann und Frau, diese haben heterosexuell und fortpflanzungswillig zu sein – so die Lehre der katholischen Kirche. Der Theologe Thomas Hieke hält das aber für eine absichtlich falsche Auslegung der Bibel, die nur der Machtsicherung diene.Florin, Christianewww.deutschlandfunk.de, Tag für TagDirekter Link zur Audiodatei

Die rechten Parteien befinden sich im Wahlkampfmodus für die Europawahl 2024. Statt mit einem Ausstieg aus der EU, werben sie mit einem "Europa der Vaterländer". Davon dürfe man sich aber nicht täuschen lassen, findet der Philosoph Christoph Quarch.Ein Kommentar von Christoph Quarchwww.deutschlandfunkkultur.de, Politisches FeuilletonDirekter Link zur Audiodatei

Dies ist die erste Folge eines Formates, wo ich Freunde und gute Bekannte einlade und sie komplett ausfrage bis ich alles weis über dieses eine Thema oder einfach nur mein ADHS befriedigt ist. Zurücklehnen und genießen. Neue Folgen erstmal alle 2 Wochen, Glocke an und 5 Sterne los los

Kazim Erdoğan hat die erste türkische Vätergruppe Deutschlands gegründet. Auf die Frage, ob Muslime in der Tendenz aggressiver sind, sagt er: Teils, teils.In einer Stadt wie Berlin, in der es ohne Fragen viele Problemzonen gibt, ist Neukölln wohl die bekannteste von allen. Neukölln ist zum Synonym von allem geworden, was in der sogenannten Integration schiefläuft. Die seinerzeit berüchtigtste Schule Deutschlands – die Rütli-Schule – ist in Neukölln. Das nachrichtenträchtigste Freibad des Landes – das Columbiabad – ebenfalls. Und spätestens seit der Serie »4 Blocks« verbinden Zuschauer kriminelles Drogenmilieu mit Neukölln. Im Podcast »Moreno+ 1« spricht Host Juan Moreno mit dem Neuköllner Familienberater Karim Erdoğan, der seit Jahrzehnten in Berlin mit Migranten arbeitet. Er weiß, dass über männliche Migranten gerne geurteilt wird. Doch statt über sie zu reden, redet Erdoğan seit Jahren mit ihnen. Er hat die erste türkische Vätergruppe gegründet, einige der Teilnehmer sind über 80 Jahre alt. »Ich habe hier Männer, die wurden vom Jugendgericht dazu verdonnert, in meiner Gruppe über ihr Rollenbild zu sprechen. Bei einigen weiß ich, dass es Jahre dauern wird, bis sie bereit sind, sich wirklich zu öffnen«, sagt Erdoğan. Der gerade in der älteren Generation so ausgeprägte Ehrbegriff, mache es diesen Männern schwer, wirklich ein Gefühl für sich und ihre Wirkung auf andere zu bekommen. »Wenn man sie fragt, was diese Ehre, von der sie ständig sprechen eigentlich bedeutet, bleibt meist nicht viel übrig. Es ist eine hohle Phrase«, so Erdoğan. +++ Alle Rabattcodes und Infos zu unseren Werbepartnern finden Sie hier: https://linktr.ee/morenoplus1 ++++++ Alle Infos zu unseren Werbepartnern finden Sie hier. Die SPIEGEL-Gruppe ist nicht für den Inhalt dieser Seite verantwortlich. +++ Alle SPIEGEL Podcasts finden Sie hier. Mehr Hintergründe zum Thema erhalten Sie bei SPIEGEL+. Jetzt für nur € 1,- für die ersten vier Wochen testen unter spiegel.de/abonnieren Informationen zu unserer Datenschutzerklärung.

Pat Hohl and Bill Meehan, renowned bloggers on Energy Central, have amassed an impressive total of half a million views on the platform. With nearly a century of combined experience in the energy industry, including almost half of that time spent working at power companies, their expertise is undeniable. In this engaging podcast series, each episode lasting between 10 to 15 minutes, Pat and Bill take a relaxed approach to exploring the ways utilities can leverage GIS (Geographic Information System) to share, understand, and capture critical utility data. Contrary to the prevailing perception of GIS as a mere repository for asset information, Bill and Pat will present a fresh perspective. They will delve into the transformative potential of GIS, demonstrating its effectiveness as a powerful tool for engaging with all utility stakeholders. The inaugural episode, titled "Sharing GIS Information," provides a glimpse into how GIS can be harnessed to foster exceptional collaboration and communication within the utility sector. Interested in transforming your utility with GIS? Start here: https://www.esri.com/en-us/industries/electric/overview In case you missed it, the full series can be found at these links: Episode 1: https://soundcloud.com/energycentral/unlocking-the-power-of-gis-with-pat-hohl-and-bill-meehan-special-series-presented-by-esri Episode 2: https://soundcloud.com/energycentral/harnessing-gis-for-utility-management-with-pat-hohlbill-meehan-special-series-presented-by-esri Episode 3: https://soundcloud.com/energycentral/the-role-of-gis-data-digital-twins-with-pat-hohl-bill-meehan-special-series-presented-by-esri Key Links: Energy Central Post with Full Episode Transcript: https://energycentral.com/o/esri/special-episode-unlocking-power-gis-sharing-understanding-and-capturing-utility GIS for Electric Utilities from ESRI: https://www.esri.com/en-us/industries/electric/overview Episode #10: ‘The Past & Future of Circuits & How GIS is Transforming the Grid, COVID-19 Response, & More' with Pat Hohl of Esri - [an Energy Central Power Perspectives™ Podcast]: https://energycentral.com/c/iu/energy-central-power-perspectives%E2%84%A2-podcast-episode-10-%E2%80%98-past-future-circuits-how  Episode #12: ‘To Unlock the Modern Utility, GIS is Key' with Bill Meehan of Esri - [an Energy Central Power Perspectives™ Podcast]: https://energycentral.com/c/iu/energy-central-power-perspectives%E2%84%A2-podcast-episode-12-%E2%80%98-unlock-modern-utility-gis Episode #47: GIS, Digital Twin, and the Intelligent Reality of Utilities Today with Pat Hohl and Bill Meehan of Esri [an Energy Central Power Perspectives™ Podcast]: https://energycentral.com/o/energy-central/special-edition-gis-digital-twin-and-intelligent-reality-utilities-today-pat-hohl Episode #80: 'Taking a Geographic Approach to Public Grid Investment' with Bill Meehan and Pat Hohl of Esri [an Energy Central Power Perspectives™ Podcast]: https://energycentral.com/o/energy-central/episode-80-taking-geographic-approach-public-grid-investment-bill-meehan-and-pat Episode #95: 'Debating Utilities' Role In Transportation Electrification' With Esri's Bill Meehan & Pat Hohl [an Energy Central Power Perspectives™ Podcast]: https://energycentral.com/o/energy-central/episode-95-debating-utilities-role-transportation-electrification-esris-bill Pat Hohl's Energy Central Profile: energycentral.com/member/profile/204983/about Bill Meehan's Energy Central Profile: https://energycentral.com/member/profile/360/about Did you know? The Energy Central Power Perspectives Podcast has been identified as one of the industry's 'Top 25 Energy Podcasts': blog.feedspot.com/energy_podcasts/

In the GIS for the utility industry and as authors on Energy Central, few have quite the pedigree of Pat Hohl and Bill Meehan as experts in their field. While the series opener offered an intriguing view into how GIS can revolutionize collaboration and communication in utility management, this second episode finds Pat and Bill moving past the conventional view of GIS as just a tool for asset data storage. The conversation offers a refreshing narrative of the broader implications of GIS, including the transformational capacity of the technology and highlighting its role as a robust facilitator for stakeholder insight in the utility sector. Curious about transforming your utility operations with GIS? Begin your journey here: https://www.esri.com/en-us/industries/electric/overview In case you missed it, the full series can be found at these links: Episode 1: https://soundcloud.com/energycentral/unlocking-the-power-of-gis-with-pat-hohl-and-bill-meehan-special-series-presented-by-esri Episode 2: https://soundcloud.com/energycentral/harnessing-gis-for-utility-management-with-pat-hohlbill-meehan-special-series-presented-by-esri Episode 3: https://soundcloud.com/energycentral/the-role-of-gis-data-digital-twins-with-pat-hohl-bill-meehan-special-series-presented-by-esri Key Links: Energy Central Post with Full Episode Transcript: https://energycentral.com/o/energy-central/special-episode-harnessing-gis-strategic-utility-insight-pat-hohl-and-bill-meehan Energy Central Post with Full Episode Transcript: XX GIS for Electric Utilities from ESRI: https://www.esri.com/en-us/industries/electric/overview Episode #10: ‘The Past & Future of Circuits & How GIS is Transforming the Grid, COVID-19 Response, & More' with Pat Hohl of Esri - [an Energy Central Power Perspectives™ Podcast]: https://energycentral.com/c/iu/energy-central-power-perspectives%E2%84%A2-podcast-episode-10-%E2%80%98-past-future-circuits-how  Episode #12: ‘To Unlock the Modern Utility, GIS is Key' with Bill Meehan of Esri - [an Energy Central Power Perspectives™ Podcast]: https://energycentral.com/c/iu/energy-central-power-perspectives%E2%84%A2-podcast-episode-12-%E2%80%98-unlock-modern-utility-gis Episode #47: GIS, Digital Twin, and the Intelligent Reality of Utilities Today with Pat Hohl and Bill Meehan of Esri [an Energy Central Power Perspectives™ Podcast]: https://energycentral.com/o/energy-central/special-edition-gis-digital-twin-and-intelligent-reality-utilities-today-pat-hohl Episode #80: 'Taking a Geographic Approach to Public Grid Investment' with Bill Meehan and Pat Hohl of Esri [an Energy Central Power Perspectives™ Podcast]: https://energycentral.com/o/energy-central/episode-80-taking-geographic-approach-public-grid-investment-bill-meehan-and-pat Episode #95: 'Debating Utilities' Role In Transportation Electrification' With Esri's Bill Meehan & Pat Hohl [an Energy Central Power Perspectives™ Podcast]: https://energycentral.com/o/energy-central/episode-95-debating-utilities-role-transportation-electrification-esris-bill Pat Hohl's Energy Central Profile: energycentral.com/member/profile/204983/about Bill Meehan's Energy Central Profile: https://energycentral.com/member/profile/360/about Did you know? The Energy Central Power Perspectives Podcast has been identified as one of the industry's 'Top 25 Energy Podcasts': blog.feedspot.com/energy_podcasts/

In the final episode of the ESRI-presented podcast series about capturing GIS information more effectively, the esteemed Pat Hohl and Bill Meehan move past the typical association of GIS with maps and move into what they believe serves a larger purpose in the realm of discovery and understanding complex data, especially within the utility sector. Pat and Bill discuss transitioning from paper to digital maps in this conversation and how utilities move towards fully connected, intelligent models for better interoperability and load flow management. The role of mobile tools and web services will serve to reduce data latency and increase transparency, with an emphasis on safety and operational efficiency. Specifically, Digital Twins combine multiple data sources like imagery, real-time sensor data, and logical representations for more informed decision-making, and this episode serves as a starting point for understanding how GIS acts as a foundation for these technologies. Want to dive in more deeply with ESRI's expertise? Start that process here: https://www.esri.com/en-us/industries/electric/overview In case you missed it, the full series can be found at these links: Episode 1: https://soundcloud.com/energycentral/unlocking-the-power-of-gis-with-pat-hohl-and-bill-meehan-special-series-presented-by-esri Episode 2: https://soundcloud.com/energycentral/harnessing-gis-for-utility-management-with-pat-hohlbill-meehan-special-series-presented-by-esri Episode 3: https://soundcloud.com/energycentral/the-role-of-gis-data-digital-twins-with-pat-hohl-bill-meehan-special-series-presented-by-esri Key Links: Energy Central Post with Full Episode Transcript: https://energycentral.com/c/iu/special-episode-role-gis-data-mobility-and-digital-twins-pat-hohl-and-bill-meehan GIS for Electric Utilities from ESRI: https://www.esri.com/en-us/industries/electric/overview Episode #10: ‘The Past & Future of Circuits & How GIS is Transforming the Grid, COVID-19 Response, & More' with Pat Hohl of Esri - [an Energy Central Power Perspectives™ Podcast]: https://energycentral.com/c/iu/energy-central-power-perspectives%E2%84%A2-podcast-episode-10-%E2%80%98-past-future-circuits-how  Episode #12: ‘To Unlock the Modern Utility, GIS is Key' with Bill Meehan of Esri - [an Energy Central Power Perspectives™ Podcast]: https://energycentral.com/c/iu/energy-central-power-perspectives%E2%84%A2-podcast-episode-12-%E2%80%98-unlock-modern-utility-gis Episode #47: GIS, Digital Twin, and the Intelligent Reality of Utilities Today with Pat Hohl and Bill Meehan of Esri [an Energy Central Power Perspectives™ Podcast]: https://energycentral.com/o/energy-central/special-edition-gis-digital-twin-and-intelligent-reality-utilities-today-pat-hohl Episode #80: 'Taking a Geographic Approach to Public Grid Investment' with Bill Meehan and Pat Hohl of Esri [an Energy Central Power Perspectives™ Podcast]: https://energycentral.com/o/energy-central/episode-80-taking-geographic-approach-public-grid-investment-bill-meehan-and-pat Episode #95: 'Debating Utilities' Role In Transportation Electrification' With Esri's Bill Meehan & Pat Hohl [an Energy Central Power Perspectives™ Podcast]: https://energycentral.com/o/energy-central/episode-95-debating-utilities-role-transportation-electrification-esris-bill Pat Hohl's Energy Central Profile: energycentral.com/member/profile/204983/about Bill Meehan's Energy Central Profile: https://energycentral.com/member/profile/360/about Did you know? The Energy Central Power Perspectives Podcast has been identified as one of the industry's 'Top 25 Energy Podcasts': blog.feedspot.com/energy_podcasts/

Autor: Alexandre Hohl

Psychedelische Salons, Analytisches Kabarett, Performances – seit drei Jahren leitet Salome Hohl das «Cabaret Voltaire» in Zürich, die Geburtsstätte des Dadaismus. Inwiefern ihr eigenes Leben Dada ist und wie sich dies in Ton und Klang niederschlägt, verrät sie in «Musik für einen Gast». Vor 117 Jahren wurde von Kunstschaffenden im Zürcher Exil der Dadaismus erfunden. Ihr Treffpunkt war das Cabaret Voltaire im Niederdorf. Heute führt die Kunsthistorikerin Salome Hohl die Geschicke dieses geschichtsträchtigen Ortes. Wie die 38-jährige Ostschweizerin das Haus durch die Pandemie und einen langwierigen Umbau gesteuert hat und warum ihr die leibhaftige Debatte und der beseelte Diskurs am Herz liegen, darüber unterhält sich Salome Hohl im Gespräch mit Hannes Hug

"Ein Lied für Dich" ist der Podcast, in dem in jeder Folge ein Song der Band Die Ärzte besprochen wird, zumindest versuchen wir es! In dieser Folge geht es um "Anti-Zombie" vom Album "Geräusch". Die Spotify Playlist mit (fast) allen Songs und Folgen chronologisch sortiert: https://spoti.fi/3gnPcHa Ihr erreicht uns über Instagram: http://www.instagram.com/wuinte http://www.instagram.com/scholz_ma

In this JCO Article Insights episode, Davide Soldato summarizes three articles from the May 20th, 2023 Journal of Clinical Oncology issue: “Smoking Cessation After Diagnosis of Kidney Cancer Is Associated With Reduced Risk of Mortality and Cancer Progression: A Prospective Cohort Study, “Efficacy of a Smoking Cessation Intervention for Survival of Cervical Intraepithelial Neoplasia or Cervical Cancer: A Randomized Control Trial” and “Integrating Tobacco Treatment into Oncology Care: Reach and Effectiveness of Evidence-Based Tobacco Treatment across National Cancer Institute Designated Cancer Centers.” The articles discuss clinical outcomes in survivors of cancers who quit smoking, efficacy of a novel smoking intervention and implementation of tobacco treatment programs. TRANSCRIPT Davide Soldato: Welcome to this JCO After Hours issue summary for the May issues of the Journal of Clinical Oncology. This is Davide Soldato and today I will be reporting results from three articles published in the May issue of JCO. Today's episode is focused on smoking cessation, impact on clinical outcomes, efficacy of novel smoking interventions, and implementations of tobacco treatment programs.  The first article by Dr. Sheikh and colleagues is titled "Smoking Cessation after Diagnosis of Kidney Cancer is Associated with Reduced Risk of Mortality and Cancer Progression: A Prospective Cohort Study". We know that smoking is a relevant risk factor for development of renal cell carcinoma, and previous retrospective studies showed better survival among patients who quit smoking after diagnosis. However, prospective data on the topic were lacking up until this point. The study by Dr. Sheikh and colleagues included patients diagnosed with renal cell carcinoma who were current smokers at the moment of diagnosis and that were followed prospectively for an average of eight years. At study inclusion, patients responded to a structured questionnaire investigating smoking habits and other behavioral factors. Furthermore, clinical pathological data were extracted from medical records.  Subsequently, after inclusion, patients provided yearly information regarding smoking status and if applicable, date of smoking cessation. Follow-up information on vital status, eventual disease recurrence, and treatments were collected both from patients and from medical records. The study reports results among 212 patients who were current smokers at diagnosis; the majority were diagnosed with stage I tumors and had a high-level education. Over the eight-year average follow-up, 40% of patients reported quitting smoking, more than half of them shortly after diagnosis. Demographic, social, and tumor characteristics were comparable between patients who quit and those who continued smoking.  Smoking cessation was overall associated with improved outcomes. Five-year survival rates were significantly higher in patients who quit smoking compared to those who continued (85% versus 61%). This higher probability of survival was observed across all evaluated subgroups, including light versus moderate and heavy smokers, and patients with early and late-stage tumors. Similarly, five-year progression-free survival rates were significantly higher among patients who quit smoking (80% versus 57%). In multivariable, time-dependent regression models adjusted for age of diagnosis, presence of other chronic health conditions, number of pack years, alcohol drinking status, tumor stage, and treatment received during follow-up, smoking cessation was significantly associated with a lower risk of all-cause mortality, disease progression, and kidney cancer-specific death. The results were comparable when excluding from the analysis patients who quit smoking three and twelve months after diagnosis, and this is important because inclusion of these patients might have biased results considering that these patients might have survived longer and thus had more chance to quit smoking.  So, in conclusion, smoking cessation among patients diagnosed with renal cell carcinoma was associated with a 50% lower risk of death, a 46% lower risk of cancer-specific death, and a 55% lower risk of disease progression. These results are extremely important and informative as they reinforce the need to promote smoking cessation among patients diagnosed with renal cell carcinoma since the observed clinical benefit was at least similar to that of currently employed or emerging targeted and immunotherapy treatments. The second article by Dr. Vidrine and colleagues is titled "Efficacy of a Smoking Cessation Intervention for Survival of Cervical Intraepithelial Neoplasia or Cervical Cancer: A Randomized Control Trial". As for many other cancers, we know that smoking is a significant risk factor for the development of cervical cancer. Furthermore, smoking after a diagnosis of cervical intraepithelial neoplasia or cervical cancer was associated with poor treatment response, increased risk of recurrence and development or worsening of other chronic diseases over the survivorship period. Cervical cancer frequently affects younger women, those with low socioeconomic status, and also minority groups. Previous data obtained specifically in these groups showed reduced access to smoking cessation intervention and consequently worse consequences from continued smoking. Consequently, the development of effective interventions to improve smoking cessation in these populations is of critical importance. The study by Dr. Vidrine and colleagues included smoking patients diagnosed and treated for cervical intraepithelial neoplasia or cervical cancer, and not already using nicotine replacement therapy. As per clinical guidelines, patients received 12 weeks of combination nicotine replacement therapy with a patch plus lozenge, and with randomized one-to-one to a standard treatment group that received educational material and a letter referring to states' tobacco cessation quick line at baseline three and six months or to the experimental intervention group. The experimental group received the standard treatment plus a novel 12 months intervention based on the Motivation and Problem-Solving approach or MAPS, aiming at facilitating and maintaining behavioral change. The intervention was co-developed with survivors of cervical cancer who smoked to target specific needs regarding smoking cessation, healthy behaviors, and other survivorship issues. The intervention was articulated on six telephone counseling sessions that were delivered over 12 months based on the needs of each patient. After randomization, patients were followed up prospectively at 3, 6, 12, and 18 months. The primary outcome of the study was self-reported seven-day point prevalence abstinence from smoking at 18 months, so, six months after the end of the intervention. The secondary outcome was biochemically confirmed seven-day point prevalence abstinence evaluated on saliva.   The study published in JCO reports results among 194 patients. The majority were non-Hispanic White, had low socioeconomic status, and were diagnosed either with cervical intraepithelial neoplasia or stage I cervical cancer. Unfortunately, the trial failed to demonstrate its primary outcome. At 18 months, the percentage of patients who quit smoking was similar, 14% in the MAPS group versus 12% in the standard treatment group. However, when examining longitudinally the percentage of patients who quit smoking at each of the four-time points, a significant interaction was observed between the smoking condition and the timing assessment. Consequently, the authors decided to investigate the percentage of patients who quit smoking at every single time point. In this analysis, a significantly higher percentage of patients who quit smoking was observed at 12 months in the experimental group, equal to 26% for the MAPS group intervention versus 12% in the standard treatment group. Furthermore, patients who completed at least four MAPS sessions had a significantly higher abstinence rate at twelve months, 38% compared to 8% for those who completed zero to three sessions.  So, in conclusion, this trial and the MAPS intervention resulted in a higher rate of abstinence at 12 months, although a considerable number of survivors relapsed six months after the end of the intervention, thus dissipating the overall effect. However, the results of this trial are extremely important because they highlight the need for further research in the field, first to improve patient engagement to smoking cessation intervention, and second, to promote sustained behavioral change that can be maintained even after the end of the active intervention phase.   Finally, the third article by Dr. Hohl and colleagues is titled "Integrating Tobacco Treatment into Oncology Care: Reach and Effectiveness of Evidence-Based Tobacco Treatment across National Cancer Institute Designated Cancer Centers." As highlighted by the previous two articles, smoking cessation is paramount for patients diagnosed with cancer and survivors of cancer. Despite the existence of specific NCCN guidelines on the topic, there is considerable evidence that smoking cessation is not commonly addressed in cancer care. So, as part of the Cancer Moonshot program, the Cancer Center Cessation Initiative was launched in 2017 with the objective of integrating evidence-based tobacco treatment into cancer care. The study by Dr. Hohl and colleagues aimed to assess the reach and effectiveness of tobacco treatment programs across NCI-designated centers included in the Cancer Center Cessation Initiative using six months of data collected from January to June 2021.  This cross-sectional study focused on two main outcomes. The first one, treatment reach, was defined as the proportion of smoking patients who received at least one tobacco treatment component over the total number of patients who reported current smoking examined in the included NCI centers. The second outcome was smoking cessation effectiveness, defined as the proportion of patients who reported seven-day point prevalence estimates of smoking cessation over the total number of patients who received at least one tobacco treatment component in the centers.  This study examined data from 28 NCI-designated centers where more than 600,000 patients were evaluated and treated. Median smoking prevalence was 7%, median reach was around 15%, and median effectiveness was around 18%. Some differences in reach and effectiveness were noted according to center characteristics, tobacco treatment program characteristics, implementation strategies, and components of the tobacco treatment programs. Smaller centers had higher reach but lower effectiveness, whereas the opposite was observed for larger centers. Additionally, centers with higher smoking prevalence had both higher reach and higher effectiveness. The centers that were implementing tobacco treatment programs center-wide had higher reach and similar effectiveness compared to centers where these programs were implemented only in part. A slightly higher effectiveness was observed in centers that targeted only outpatients, possibly due to different patterns of care and clinical outcomes among inpatients. eReferral systems to smoking cessation quick lines that were used by 90% of the centers were associated with increased effectiveness when a closed-loop system was implemented.  Regarding the type and the component of the tobacco treatment programs, almost all centers offered at least four quick line referrals at the second higher median reach of 17% and also effectiveness 19%. Face-to-face counseling with tobacco treating specialists had the highest median effectiveness, almost 20%. All the other components, including pharmacotherapy, telephone-based counseling, and point-of-care counseling, had similar median reach and effectiveness.   Overall, these results are important as they are able to inform future resource allocation, tobacco treatment program design, and implementation according to center characteristics in order to improve reach and effectiveness of these tobacco treatment programs.   This is Davide Soldato, and in this episode of JCO Article Insights, we discussed three articles on the topic of smoking cessation. The first article, by Dr. Sheikh and colleagues, described clinical outcomes among patients who quit smoking after a diagnosis of renal cell carcinoma and demonstrated that those patients who quit had increased survival benefits. The second article, by Dr. Vidrine and colleagues, reported the efficacy results of a novel intervention to promote smoking cessation among patients diagnosed and treated with cervical intraepithelial neoplasia or cervical cancer. The second article showed that, although the primary outcome was not reached, a higher percentage of patients quit smoking with this novel intervention at twelve months. Finally, the third article, by Dr. Hohl and colleagues, examined characteristics and implementation strategies of tobacco treatment programs among NCI-designated centers, and the results of this study will be important to improve the reach and effectiveness of this program over the years.   Thank you for your attention and stay tuned for the next episode of JCO Article Insights.   The purpose of this podcast is to educate and to inform. This is not a substitute for professional medical care and is not intended for use in the diagnosis or treatment of individual conditions.  Guests on this podcast express their own opinions, experience, and conclusions. Guest statements on the podcast do not express the opinions of ASCO. The mention of any product, service, organization, activity, or therapy should not be construed as an ASCO endorsement.  Show Notes: Like, share and subscribe so you never miss an episode and leave a rating or review. Articles Smoking Cessation After Diagnosis of Kidney Cancer Is Associated With Reduced Risk of Mortality and Cancer Progression: A Prospective Cohort Study Efficacy of a Smoking Cessation Intervention for Survival of Cervical Intraepithelial Neoplasia or Cervical Cancer: A Randomized Control Trial Integrating Tobacco Treatment into Oncology Care: Reach and Effectiveness of Evidence-Based Tobacco Treatment across National Cancer Institute Designated Cancer Centers. Find more articles from the May 20 issue.  

Wenn Nico durch Köln läuft, fällt er auf. Er läuft nur noch barfuß und hat mit Laufschuhen schon lange abgeschlossen. Wie wird man Barfußläufer und vor allem warum? Und in wie viele Scherben ist Nico schon getreten? Wie es bei Schmidti und Hendrik vorangeht und bei welchen Wettkämpfen sie in dieser Woche in Erscheinung treten - auch das erfahrt ihr in Folge 32 von #1rennt1hinterher! —  Einer rennt Einer hinterher ist auf Spotify, Apple Podcasts, Amazon Music, Anchor und Google Podcasts für euch verfügbar. Bei Instagram halten wir euch bei @1rennt1hinterher auf dem Rennenden. — Zur 1rennt1hinterher-Spotify-Playlist: ⁠https://open.spotify.com/playlist/0kVAZSEIqcLtDEttdsUyin⁠  —  Zur Exakt Health App mit den Reha- und kostenlosen Präventionsplänen. Mit dem Code HENDRIK könnt ihr auch die Reha-Pläne einen Monat kostenlos ausprobieren: ⁠https://www.exakthealth.com/hendrik⁠   — Im 3Bears Shop erhaltet ihr mit unserem Rabattcode EINERRENNT15 15% Rabatt auf das gesamte Sortiment - vom klassischen Porridge über Pasta bis zu den leckeren Haferpancakes und Bananebrot. ⁠https://3bears.de⁠ 

Celebrity culture has been around for a long time - from royals to movie stars, gossip magazines and red carpets have been filled with mystery and intrigue into the lives of those that society put on a pedestal.But Bennifer walked so Alix Earle could run - thanks to new generations, evolved technology, and a rapidly shifting social environment, the celebrities of our modern world are changing.In this episode, I'm joined by Affiliate Marketing Extraordinaire Andy Hohl, who managed Brand Partnerships and Sales with MagicLinks. His experience with talent agencies in LA to affiliate and influencer marketing in Miami gives Andy a unique view into how influencer marketing has been inspired by celebrity partnerships, as well as where the two differ.He provides his perspective on the future of social media celebrities, and how this digital medium gives audiences an exclusive look into the lives of those admired by society. We explore celebrities-turned-influencer and influencers-turned-celebrity, and how these worlds continue to collide and shape the future of both industries - all fueled by social media.To connect with Andy, click here. To connect with Hillary, click here. Read more about Digital HQ here.For more episodes, go to SOCIALCOMPLEXPOD.COMProduced by You Lucky Dog Productions.

Fischer, Karinwww.deutschlandfunk.de, Kultur heuteDirekter Link zur Audiodatei

Time Stamps:(0:50) - Introduction to Unik Labs and Pauline(3:10) - Inspiration for Unik Labs(5:50) - How the platform works(8:37) - Not in one box - somewhere between education and gaming(12:33) - Approach to educating people and focus on people that are already active in the Web3 community(12:37) - What is the grand vision of Unik Labs?(16:04) - Why is digital fashion important?(21:50) - How Pauline's background relates to where she is today?(24:51) - What does it mean to be a designer today? How has the definition of “creator” changed?(30:00) - You can no longer ignore the new age of digital fashion(32:50) - Brands that understand the power of Web3 - Gucci's engagement with gamers and Gen Z(40:45) - Closing thoughtsFind Pauline and Unik Labs:On their website = https://www.uniklabs.xyz/simagineOn Twitter = https://twitter.com/UnikLabsv & https://twitter.com/pauline_unikFind Neustreet:On YouTube = https://www.youtube.com/channel/UCvY8En8CbNcj3tNP-BEzlyAOn our website = https://neustreet.com/On Twitter =  https://twitter.com/realneustreetOn Instagram = https://www.instagram.com/realneustreetOn TikTok = https://www.tiktok.com/@neustreet

Our guest this week is Matt Alexander, co-founder and CEO of Neighborhood Goods, recorded live at GroceryShop in Las Vegas. In a wide-ranging and thought-provoking interview, we first learn about the inspiration and evolution of Neighborhood Goods from a big picture vision to three physical locations (Dallas, New York and Austin, with more on the way). We then explore Matt's creative and unique take on concept development, merchandising, story-telling, and more, before moving into his fascinating thoughts on leadership, innovation, and more broadly, how culture affects retail. We wrap up with what's next for Neighborhood Goods (with a bit of existentialist philosophy thrown in for good measure).But first we take on the week in retail news, kicking off with a big picture overview of monthly sales and lots of retail earnings reports. We ponder what it all might mean for the near future, particularly as several retailers "pull their guidance." We then offer up quick hits on the decent (Walmart, Home Depot), the bad (Target), and the ugly (Kohl's), while considering whether Macy's "Polaris Strategy" is actually working. We conclude with our thoughts on the coming lay-offs and potential strategic shake-ups at Amazon.Steve's Forbes article on Macy's Turnaround StrategyCatch Steve and Michael at NRF's Big ShowPast Episodes MentionedLori Stillman, from the National Association of Convenience StoresTarget SVP Nancy KingThe Citizenry's Rachel Bentley and Carly Nance About MattMatt is the co-founder and CEO of Neighborhood Goods.In his spare time, amongst other things, Matt is co-founder of not-for-profit, Unbranded, co-host of Bonanza! on Relay FM, a member of SMU's Dedman Executive Board, and advisor to a number of startups and accelerators.Matt has been fortunate to be named as one of Monocle's Top 25 Entrepreneurs, D CEO's Most Influential Leaders, FGI's Rising Stars, and more. Meanwhile, Neighborhood Goods has been named one of Fast Company's Most Innovative Companies, Chain Store Age's Breakout Retailers, and more.About UsSteve Dennis is an advisor, keynote speaker and author on strategic growth and business innovation. You can learn more about Steve on his       website.    The expanded and revised edition of his bestselling book  Remarkable Retail: How To Win & Keep Customers in the Age of Disruption is now available at  Amazon or just about anywhere else books are sold. Steve regularly shares his insights in his role as a      Forbes senior contributor and on       Twitter and       LinkedIn. You can also check out his speaker "sizzle" reel      here.Michael LeBlanc  is the Founder & President of M.E. LeBlanc & Company Inc and a Senior Advisor to Retail Council of Canada as part of his advisory and consulting practice.   He brings 25+ years of brand/retail/marketing & eCommerce leadership experience, and has been on the front lines of retail industry change for his entire career.  Michael is the producer and host of a network of leading podcasts including Canada's top retail industry podcast,       The Voice of Retail, plus  Global E-Commerce Tech Talks  ,      The Food Professor  with Dr. Sylvain Charlebois and now in its second season, Conversations with CommerceNext!  You can learn more about Michael   here  or on     LinkedIn. Be sure and check out Michael's latest venture for fun and influencer riches - Last Request Barbecue,  his YouTube BBQ cooking channel!

Today I speak with Andy Hohl, Brand Partnerships and Sales at MagicLinks. As Public Relations and Affiliate Marketing continue to merge, we at JEBCommerce try to bring you the conversations that will help you navigate this brave new world. And this is just one of those conversations.MagicLinks is an influencer platform, working with over 25,000 influencers and 4500 brands. Andy and I discuss best practices in working with MagicLinks, their influencers, and integrating affiliate marketing and PR in this way.Andy has been working in PR and Affiliate Marketing for over a decade and has seen the transition and the integration of these two channels happen for some time. Needless to say, he has some great insight.If you are trying to navigate this new thing, this is definitely the episode for you.Want to contact Andy? Follow him on LinkedIn or email.

Heye meine Zuckerschnuten, Moritz Hohl ist zu Gast diese Woche. Es geht um: - Apache im Stripclub getroffen - Arschlochlecken lassen - Konrads Bi Erfahrungen - Tim ist verkatert und weis wenig von gestern und viiiiiiiiiiiieles mehr ganz viel Spaß Instagram Konrad: KonradGrosz Tim: Tim.psr Moritz: Moritz_Hohl

In this special episode of the Broalie Talks Hockey Podcast I am joined by Garret Hohl. We discuss how he got involved with sports analytics, how he started Hockey Graphs and HockeyDataInc. We also discuss the jets moves and management, hope you enjoy!

Top analytics guy and Winnipeg Jets follower Garret Hohl is here to talk Jets with Victor and Jesse. Pros discussed include Kyle Connor, Mark Scheifele, Blake Wheeler, Nikolaj Ehlers, Pierre-Luc Dubois, Morgan Barron, Evgeny Svechnikov, Mason Appleton, Josh Morrissey, Neal Pionk, Nate Schmidt, Logan Stanley, Collor Hellebuyck, Eric Comrie, and Mikhail Berdin. Dan Tiffany joins for "Tiff's Takes" on the goalies. In the Dynasty Dig, Prospects discussed are Cole Perfetti, Chaz Lucius, and Ville Heinola. Thanks to FHL Scout Jeremy for the Lucius scouting report. Mason Black @NHLRankKing has poll results comparing these prospects to similarly rostered prospects and Jesse and Victor debate them. Jesse pays off a joke from the prior episode. Our show is presented by Fantrax.com and proud to be a part of the Dobber Podcast Network. Email fantasyhockeylife@gmail.com and ask to join our free discord. Join our Patreon at Patreon.com/fantasyhockeylife for rankings, bonus podcasts, in-depth prospect reports with video, show notes and more. Listen and subscribe wherever podcasts are posted - and give us 5 stars! We want to be your best place to talk about the game of dynasty fantasy hockey.

What does it actually mean to be winning in service design? A question I think we don't ask ourselves often enough. Because when you put your entire heart and soul into delivering a great project but the results aren't adopted by the organization, can you say that it was a success? Most service design professionals I know genuinely want to make a tangible impact on the people and organizations they work with. This means that your work can't stop at the research or idea stage. If the recommendations aren't operationalized, that amazing journey map you've created isn't worth a lot. So how do you increase the likelihood that your work makes it into the real world? Well, in this episode, Markus Hohl, the global head of service design at JP Morgan, shares his approach. The conversation with Markus shows again that we often tend to overcomplicate things. The encouraging thing is that you should actually do less, not more, to be more impactful. Markus has found that by doubling down on just 3 simple things, he can get way more done inside the organization. Once you see what they are, it all makes sense as it goes with these things. But it can take years before you gain this clarity. What I found really valuable is that Markus brings the agency and in-house perspective. As you'll hear, both have their advantages and drawbacks. As always, enjoy and keep making a positive impact :) --- [ 1. GUIDE ] -— 00:00 Welcome to episode 147 04:50 Who is Markus 05:20 60 second rapid fire 08:00 The journey 14:00 Roles and responsibilities 19:15 How do you know you're winning 23:45 It doesn't go anywhere 27:30 When service design works 30:00 Benefit of the doubt 35:00 Selling the work 41:00 The biggest hurdles 44:15 This gives confidence 47:00 The future of agencies 49:15 Closing thoughts --- [ 2. LINKS ] --- https://www.linkedin.com/in/markushohl/ Sapiens: A Brief History of Humankind (book): https://amzn.to/3veH2dD --- [ 3. SELLING SERVICE DESIGN WITH CONFIDENCE ] --- For more information and instructions on how to apply head over to: https://servicedesignshow.com/selling

This month on Episode 34 of Discover CircRes, host Cynthia St. Hilaire highlights four original research articles featured in the March 4 and March 18th issues of Circulation Research. This episode also features a conversation with Dr Mireille Ouimet and Sabrina Robichaud from the University of Ottawa Heart Institute to discuss their study, Autophagy is Differentially Regulated in Leukocyte and Non-Leukocyte Foam Cells During Atherosclerosis.   Article highlights:   Pauza, et al. GLP1R in CB Suppress Chemoreflex-Mediated SNA   Lim, et al. IL11 in Marfan Syndrome   Hohl, et al. Renal Denervation Prevents Atrial Remodeling in CKD   Liu, et al. Smooth Muscle Cell YAP Promotes Arterial Stiffness   Cindy St. Hilaire:        Hi and welcome to Discover CircRes, the podcast of the American Heart Association's journal, Circulation Research. I'm your host, Cindy St. Hilaire from the Vascular Medicine Institute at the University of Pittsburgh, and today I'm going to be highlighting articles from our March issues of Circulation Research. I'm also going to speak with Dr Mireille Ouimet and Sabrina Robichaud from the University of Ottawa Heart Institute, and they're with me to discuss their study, Autophagy is Differentially Regulated in Leukocyte and Non-Leukocyte Foam Cells During Atherosclerosis.   The first article I want to share is titled GLP1R Attenuates Sympathetic Response to High Glucose via Carotid Body Inhibition. The first author is Audrys Pauza, and the corresponding authors are Julian Paton and David Murphy at the University of Bristol.   Cindy St. Hilaire:        Hypertension and diabetes are risk factors for cardiovascular disease. And yet, for many patients with these two conditions, lowering blood pressure and blood sugar is insufficient for eliminating the risk. The carotid body is a cluster of sensory cells in the carotid artery, and it regulates sympathetic nerve activity. Because hypertension and diabetes are linked to increased sympathetic nerve activation, this group investigated the role of the carotid body in these disease states. They performed a transcriptome analysis of crowded body tissue, from rats with and without spontaneous hypertension. And they found among many differentially-expressed genes that the transcript encoding glucagon-like peptide-1 receptor or GLP1R, was considerably less abundant in hypertensive animals.   Cindy St. Hilaire:        This was of particular interest because the gut hormone GLP-1 promotes insulin secretion and tends to be suppressed in Type 2 diabetes. Moreover, GLP1R agonists are already used as diabetic treatments. This group showed that treating rat carotid body with GLP1R agonist suppresses sympathetic nerve activation and arterial blood pressure, suggesting that these drugs may provide benefits in more than one way. Perhaps the carotid body could be a novel target for lowering cardiovascular disease risk in metabolic syndrome.   Cindy St. Hilaire:        The second article I want to share is titled Inhibition of IL11 Signaling Reduces Aortic Pathology in Murine Marfan syndrome. The first author is Wei-Wen Lim, and the corresponding author is Stuart Cook and they're from the National Heart Center in Singapore. People with the genetic connective tissue disorder Marfan syndrome, are typically tall and thin with long limbs and are prone to skeletal, eye and cardiovascular problems, including a life-threatening weakening of the aorta. While Marfan syndrome patients commonly take blood pressure-lowering treatments to minimize risk of aortic aneurysm and dissection, there's currently no cure for Marfan syndrome or targeted therapy.   Cindy St. Hilaire:        The cytokine IL11 is strongly induced in vascular smooth muscle cells upon treatment with the growth factor TGF-beta, which is over activated in Marfan syndrome patients. And TGF-beta is also considered a key feature of the syndrome's molecular pathology. This study found that IL11 is strongly upregulated in the aortas of Marfan syndrome model mouse, and that genetically eliminating IL11 in these animals protected them against aortic dilation, fibrosis, inflammation, elastin degradation and loss of smooth muscle cells. Treating Marfan syndrome mice with anti-IL11 neutralizing antibodies exhibited the same beneficial effects. These results suggest that perhaps inhibiting IL11's activity could be a novel approach for protecting the aortas of Marfan syndrome patients.   Cindy St. Hilaire:        The next article I want to mention is titled Renal Denervation Prevents Atrial Arrhythmogenic Substrate Development in Chronic Kidney Disease. The first authors are, Mathias Hohl, Simina-Ramona Selejan and Jan Wintrich, and the corresponding authors also Mathias Hohl, and they're from Saarland University. People with chronic kidney disease have a two to three fold higher risk than the general population of developing atrial fibrillation, which is a common form of arrhythmia that can be life-threatening. Chronic kidney disease is associated with activation of the sympathetic nervous system, which can be damaging to the heart. Thus, this group examined myocardial tissues from atrial fibrillation patients with and without chronic kidney disease to see how they differ. They found that atrial fibrosis was more pronounced in patients with both conditions than in patients with atrial fibrillation alone, suggesting that chronic kidney disease perhaps exacerbates or even drives arterial remodeling.   Cindy St. Hilaire:        Sure enough, induction of chronic kidney disease in rats led to greater atrial fibrosis and incidence of atrial fibrillation than seen in the control animals. Renal denervation is a treatment in which the sympathetic nerves are ablated, and it's a medical procedure that's used for treating uncontrolled hypertension, and it has also been shown in animals to reduce atrial fibrillation. Performing renal denervation in the rats with chronic kidney disease reduced atrial fibrosis and atrial fibrillation susceptibility. This study not only shows that chronic kidney disease induces atrial fibrosis and in turn atrial fibrillation, but also suggests that renal denervation may be used in chronic kidney disease patients to break this pathological link and prevent potentially deadly arrhythmias.   Cindy St. Hilaire:        The last article I want to highlight is titled YAP Targets the TGFβ Pathway to Mediate High-Fat/High-Sucrose Diet-Induced Arterial Stiffness. First author is Yanan Liu and the corresponding author is Ding Ai from Tianjin Medical University. Metabolic syndrome is characterized as a collection of conditions that increase the risk of cardiovascular diseases, such as obesity, hypertension and diabetes. Among the tissue pathologies associated with metabolic syndrome is arterial stiffness, which itself is a predictor of cardiovascular disease incidence and mortality. To specifically investigate how arterial stiffness develops in metabolic syndrome, this group fed mice a high-fat, high-sugar diet, which is known to induce metabolic syndrome and concomitant arterial stiffness.   Cindy St. Hilaire:        After two weeks on the diet, the animals' aorta has exhibited significant upregulation of TGF-beta signaling, which is a pathway known for its role in tissue fibrosis, and the aorta has also exhibited increased levels of yes-associated protein, or YAP, which has previously been implicated in vascular remodeling, collagen deposition and inflammation. YAP gain and loss of function experiments in transgenic mice revealed that while knockdown of protein in the animals' smooth muscle cells attenuated arterial stiffness, increased expression exacerbated the condition.   Cindy St. Hilaire:        The team went on to show that YAP interacted with and prevented the activation of PPM-1 B, which is a phosphatase that normally inhibits TGF-beta signaling and thus fibrosis. Together the results suggest that targeting the YAP, PPM-1 B pathway, could be a strategy for reducing arterial stiffness and associated cardiovascular disease risk in metabolic syndrome.   Cindy St. Hilaire:        Today, Sabrina Robichaud and Dr Mireille Ouimet from University of Ottawa Heart Institute are with me to discuss their study Autophagy is Differentially Regulated in Leukocyte and Non-Leukocyte Foam Cells During Atherosclerosis, which is in our March 18 issue of Circulation Research. So thank you both for joining me today.   Sabrina Robichaud:    Thank you so much for having us. It's a pleasure.   Mireille Ouimet:         Thank you for having us.   Cindy St. Hilaire:        Yeah, and congrats on the study. So we know that LDL particles contain cholesterol and fats, and these are the initiating factors in atherosclerosis. And it's also really now appreciated that inflammation in the vessel wall is a secondary consequence to this lipid accumulation. Macrophages are an immune cell that, in the context of the plaque, gobble up this cholesterol to the point that they become laden with lipids and exhibit this foamy appearance, which we now call foam cells. And these foam cells can exhibit atheroprotective properties, one of them called reverse cholesterol transport, and that's really one of the focuses of your paper. So before we dig into what your paper is all about, could you give us a little bit of background about what reverse cholesterol transport is in the context of the atherosclerotic plaque? And maybe introduce how it links to this cellular recycling program, autophagy, which is also a big feature of your study.   Mireille Ouimet:         Yes, so the reverse cholesterol transport pathway is a pathway that's very highly anti-atherogenic. It's linked to HDL function and the HDL protective effects, in that HDL can serve as a cholesterol acceptor for any excess cholesterol from arterial cells or other cells of the body and return this excess cholesterol to the liver for excretion into the feces. There is also trans-intestinal cholesterol efflux that can help eliminate any excess bodily cholesterol. Mireille Ouimet:         So reverse cholesterol transport is a way that we can eliminate excess cholesterol from foam cells in the vascular wall, and that's why we're really interested in the process. But the rate-limiting step of cholesterol efflux out of foam cells in plaques is actually, they have to be mobilized in the form of free cholesterol to be pumped out of the cells through the action of the ATP-binding cassette transporters. And so the rate-limiting step of the process is the hydrolysis of the cholesterol esters and the lipid droplets, because that's where the excess cholesterol is stored in foam cells.   Mireille Ouimet:         And so for years, people investigated the actions of cytosol like lipases in mobilizing free cholesterol from lipid droplets, although the identity of those lipases are not well-known and in macrophage themselves, but our recent work showed a role for autophagy in the catabolism of lipid droplets. And in fact, in macrophage foam cells, 50% of lipid droplet hydrolysis is attributable to autophagy while the other half is mediated by neutral lipases, which makes it really important to investigate the mechanisms of autophagy-mediated lipid droplet catabolism.   Cindy St. Hilaire:        That is so interesting. I guess I didn't realize it was that significant a component in that kind of rate-limiting step. That's so cool. So really, a lot of the cholesterol efflux studies, and maybe this is just limited to my knowledge of a lot of these cholesterol efflux studies, but to my knowledge, it's been really focused on the foam cell itself, the macrophage foam cell. However, there's been a lot of recent work that has now implicated vascular smooth muscle cells in this process. So could you share some of the research specific to smooth muscle cells and smooth muscle-derived foam cells that led you to want to investigate the contributions of smooth muscle cell-derived foam cells in cholesterol efflux?   Mireille Ouimet:         Yeah, so you're right in the sense that macrophages have always been the culprit foam cells in the atherosclerotic plaques but pioneering work from several groups, including Edward Fisher and Gordon Francis, they've shown that the smooth muscle cells can actually acquire a macrophage-like phenotype becoming lipid-loaded and foamy. And there's been work specifically looking at the ABC transporters, and their ability to efflux cholesterol from these vascular smooth muscle cell-derived foam cells, because as they trans-differentiate into macrophage-like cells, they acquire the expression of ABCA1, but this is to a lower extent, as compared to their macrophage counterparts.   Mireille Ouimet:         And the efflux is defective because there's an impairment in liposomal cholesterol processing of the lipoproteins that's really important to activate a like cell, and the expression of the ABC transporters, so vascular smooth muscle cell-derived foam cells are very poor effluxes.   Sabrina Robichaud:    There's very few studies that look at the vascular smooth muscle cell foam cells, and the very few that did look at it mostly focused on the ABCA1 transporters, and did show that they were poor effluxes. And as we all know, ABC1 is not the only cholesterol transporters that can transport cholesterol out of cells, there's also ABCG1 which is also one of our major findings in our paper.   Cindy St. Hilaire:        Can you tell us a little bit about the models you chose in the study and why you picked them? And also maybe a step back in terms of, what are the pros and cons of using mouse models in atherosclerotic studies?   Sabrina Robichaud:    So we chose to use the GFP-LC3 reporter mouse model because it allows us to track in lifestyle the movement of LC3, which is the main component of the autophagosome which is involved in pathology. So by using this reporter model, we could infer whether or not the cells had high autophagy or low autophagy. And to induce atherosclerosis in these mice, instead of backcrossing them to either an LDLR knockout or an ApoE knockout, we chose to do the adeno-associated virus that encode the gain of function PCSK9 instead to kind of minimize the time for breeding. It did have the effect that we needed in terms of raising plasma cholesterol to induce the atherosclerosis. So that was one of the models that we used in our paper.   Mireille Ouimet:          There's not very many good mouse models to study autophagy flux in vivo and GFP-LC3 is kind of the main one currently. We're working on developing some other tools to track lipophagy in vivo, but these things take time to put in place. So in the future, we hope to have some better tools to track lipophagy in real-time in vivo.   Cindy St. Hilaire:        How difficult is it to measure autophagy flux in vivo? I know there's certain part like LC3 or P62, a lot of people use a western blot and it's like, oh, it's high, it must be active, but it's a flux. So it's a little bit more... There's more subtleties to that, dynamic than that. So how difficult is it to really measure this flux in in vivo tissues?   Mireille Ouimet:         Yes, so now there are more recent mouse models that have been developed more recently to replace kind of the GFP-LC3 is the Rosella LC3. So it has both a red and a green tag, and so two LC3, so when autophagosomes are fused to lysosomes and are degraded, then there's preferential quenching of the GFP first, and then you have the red appearance that predominates so we know that then it's kind of like it a live flux measurements. Because we use the GFP-LC3 mouse, Sabrina treated her cells ex vivo. When we dissected out the aortic arches, digested the cells then we divided those into two components and added bafilomycin so that we can inhibit lysosome acidification to see the changes in the flux. And that's really to get the differences in untreated versus bafilomycin-treated.   Mireille Ouimet:         When we inhibit the lysosome, then we're sure that it is a functional flux or not. But it's kind of an indirect way of measuring it, and it reads very complex when we're talking about P62 and LC3 degradation with or without lysosome inhibition, but you really need that lysosomal inhibition, to show that if you block the degradation of the autophagosomes that fuse in with a lysosome, then you get an increase in the LC3 and the P62, and that's when you know that the flux is you intact.   Mireille Ouimet:         Because you could get an increase in LC3, that's just related to a defect in the breakdown of the autophagosome. But in our study, we've used phosphorylated ATG16L1, which is a now better marker of active autophagy. And I would recommend researchers to begin to use that rather than the combination of P62 and LC3 together with or without a lysosome inhibitors such as- Cindy St. Hilaire:        Oh, interesting. So let's repeat that, phosphorylated ATG-   Mireille Ouimet:         16L1, yes. So there's been an antibody that was developed by a colleague at the University of Ottawa, Dr Ryan Russell, and it's commercially available through cell signaling now, and it really has been a great tool to track active autophagy.   Cindy St. Hilaire:        That's great. I remember my lab was looking at that at one point, and I was trying to explain the flux as... I don't know if people are going to remember this, but there's this amazing, I Love Lucy skit, where her and Ethel are working on a chocolate factory conveyor belt, and it picks up speed. And because she can't get it all done quick, she starts stuffing them in her mouth. And it's like, if you just took a snapshot of that, you would not know whether it's going too fast, or not functioning properly. And so I equate the flux experiments to that. Which are probably aging myself a lot on so.   Cindy St. Hilaire:        All right, so sticking to kind of the autophagy angle, what were the differences you found in autophagy in early and late atherosclerotic plaques? Because I know you looked at those two time points, but also, importantly, between the macrophage foam cells and the smooth muscle cell-derived foam cells?   Sabrina Robichaud:    So surprisingly, there weren't that big of a difference between each time point when we were looking at the individual cell type by themselves. Surprisingly, we did find that the macrophages did have a functional autophagy flux, even at the later stages of atherosclerosis, which was kind of interesting in itself. But when we looked at the vascular smooth muscle cell foam cells, though, that was a whole other story, and we found that these were actually defective at a very early stage and stayed defective up until the very late stage of atherosclerosis.   Cindy St. Hilaire:        And what is the very early stage like? What's that definition with the smooth muscle cell?   Sabrina Robichaud:    So we did a six-week time points in terms of our atherosclerosis study, and then a 25-week time point. So there are far apart, which shows like the very early, early stage and what would be considered the most effective autophagy at that point with the necrotic core and everything. So surprisingly, the two phenotype were quite similar at early and both late stages for both cell types, but were functional in the macrophages but dysfunctional in the smooth muscle cells.   Cindy St. Hilaire:        So you mentioned at one point in the discussion that you observed inconsistent lipid loading of the smooth muscle cells, and you mentioned that a lipase, which is excreted from the foam cells can then be internalized by, I assume kind of neighboring or in the vicinity, smooth muscle cells. And so the question I had it's kind of one of those chicken-and-egg question, and it's, is the smooth muscle cell-derived foam cell an independent process? Does it happen alone or de novo as a function of a smooth muscle-mediated process? Or is it really dependent first on this macrophage foam cell providing this lipid that is efflux that is then internalized by a smooth muscle cell that kind of goes on to become a foam cells. It's kind of a question of like the continuum of an atherosclerotic plaque and what do you think is happening, either based on your data or just kind of a hunch?   Mireille Ouimet:         That's an excellent question. And there's no doubt that macrophages really drive the initiating events of atherosclerosis. So I don't think that without the macrophage there would ever be a vascular smooth muscle cell, or there would be minimal vascular smooth muscle cell-derived foam cells. Definitely the inconsistencies that we observed in our study, were if we added like aggregated LDL on its own to a primary mouse vascular smooth muscle cell, we would get poor lipid loading and a very low percentage of those cells that would become foamy, relative to treating them with cyclodextrin complex cholesterol, for instance.   Mireille Ouimet:         So free cholesterol, that's cell permeable, will go into the vascular smooth muscle cell, no problem, and generate the foaminess and then allow that cell to acquire the macrophage-like phenotype. But aggregated LDL on its own in our hands, just gave very poor loading. And when we treated the vascular smooth muscle cells with aggregated LDL along with macrophage-derived condition media, we got some improvements, but it was still kind of inconsistent. But then we thought if we treat the vascular smooth muscle cells with aggregated LDL in the presence of conditioned media from macrophage foam cells that were preloaded with the aggregated LDL, would that promote their foaminess to a greater extent? And it did.   Mireille Ouimet:         So, there have been studies from Gordon Francis's lab that showed that adding recombinant lysosomal acid lipase to vascular smooth muscle cells that contained aggregated LDL, promoted the lysosomal hydrolysis of the aggregated LDL and to generate the foamy macrophages and allow the lysosomal processing. So we know that that vascular smooth muscle cells take up lysosomal acid lipase, and we know that macrophages undergo lysosome exocytosis and they can secrete lysosome acid lipase and acidify the extracellular milieu.   Mireille Ouimet:         So work from Fred Maxfield group has shown the presence of these cell surface connected compartments that are acidified, containing macrophage-derived lysosomal acid lipase, that even hydrolyze extra cellularly-aggregated LDL for macrophages. So we're not sure whether there's probably a local production of free cholesterol in the plaque by macrophages, this free cholesterol could be taken up by the vascular smooth muscle cell. And also the vascular smooth muscle cells do express some scavenger receptors, whether the expression of these scavenger receptors like LRP or CD36 even goes up when they've taken up a little bit of the free cholesterol. And then that allows the aggregated LDL to come in and then there would be some lysosomal acid lipase secreted by the macrophage foam cells that would promote the lysosomal processing of this aggregated LDL. All of those are very complex questions that will require some addressing in vivo models.     Cindy St. Hilaire:        You also mentioned in the paper that studies... There's a handful of them now. Studies have shown that between 30% and 70% of the cells that are staining positively for macrophage markers, meaning they're foam cells, are of the smooth muscle cell lineage. And so I believe people have seen that in mouse plaques with lineage tracing, but they've also used newer techniques to really see this also in human atherosclerotic plaques. So we know it's not just from a mouse, we know that smooth muscle cells can turn into a macrophage-like foam cell, and it's 30% to 70%, which is a huge range. Cindy St. Hilaire:        So do we know the factors that dictate whether a specific plaque is going to have more or less smooth muscle cell derived foam cells? And I guess more important to what you found in your paper is, how important would it be to know whether a plaque is on the 30% end or on the 70% end in terms of therapeutic strategies?   Sabrina Robichaud:    Yeah, most of these studies, the range can be attributed to the different time points at which these studies have been collected early on will be a little bit more macrophage understanding would be at a later time point. Now of course in terms of therapeutics, as we saw in our paper, metformin actually will positively increase cholesterol efflux in the vascular smooth muscle cell foam cells, but not in the macrophages. So obviously, being able to know at which point there's a majority of macrophages versus vascular smooth muscle cells, definitely going to determine which therapeutic we're going to be able to use.   Sabrina Robichaud:    Ideally, we would be able to find a therapeutic that would work in both foam cell, but from what we've seen, the mechanistic behind the autophagy dysfunction between both cell types are so different, that I'm not entirely sure that that would be possible, we would need some sort of combination therapy. But again, we need to be a little bit more targeted depending on the percentage of the foam cells that are comprising the plaque at that particular moment in time.   Cindy St. Hilaire:        Yeah, so you mentioned there's a function of time there. If you look earlier, there's more macrophage, if you look later, the percent of smooth muscle cell-derived foam cell increases. Is there a point in a very advanced atherosclerotic plaque where it's just mostly smooth muscle cells? Or do those macrophage foam cells stay, and it's just the increasing number of smooth muscle cell-derived foam cells? Do we know?   Mireille Ouimet:         This is an excellent question, and I was going to bring up the topic of clonal expansion of the vascular smooth muscle cells. So it's a very heterogeneous population and understanding that might be some of the differences that we see in different studies. It could be the model has one type of a smooth muscle cell that's expanding more than another, what are the factors that govern that? Does one clone take over at the later stages versus the earlier stages? We don't know.   Mireille Ouimet:         But we were surprised in our studies to see that the macrophages that are present at least on the lumen of the plaques were very active in autophagy. They had the highest staining for the phospho-ATG16L1 in that late stage. So we're not sure if it's newly-recruited macrophages that come in, that are more active and in autophagy, and then have good lysosomal capacity that keeps degrading the lipid present in the plaque and tries to ingest it, but also as a consequence keeps releasing some of the degraded cholesterol into the milieu where the smooth muscle cells that are proliferating are internalizing it and becoming more foamy. So these are really great open questions that need to be addressed in the field.   Cindy St. Hilaire:        So drug-eluting stents are coated with rapamycin or the various chemical compositions that are derived from rapamycin. And rapamycin itself induces autophagy. So while the thought behind using this coating on stents was to prevent smooth muscle cell proliferation, and thus restenosis or ingrowing of the stent, your study suggests that this could also help to promote autophagy in the cells underlying the stent. So has anyone gone in and looked at plaques that have been stented and either failed or not, and investigated the foam cell content or markers for autophagy activity?   Mireille Ouimet:         Not to my knowledge, and this has been something we've definitely... We think that this is what's happening. Some of the protective effects of these drug-eluting stents that have everolimus or sirolimus or the rapamycin or rapamycin analogs, we do believe that some of their protective effect can be attributed to autophagy activation, but this remains to be demonstrated. We think that autophagy activation locally would promote reverse cholesterol transport and would be one of the processes that prevents restenosis because we can promote the efflux of cholesterol out.   Cindy St. Hilaire:        Great. So I guess stemming from my question on the stents, what are the other translational implications of the findings of your study? And what would you like to see come out of this?   Mireille Ouimet:         So one of the things is, as Sabrina mentioned, would be to target both foam cell populations because it seems as though the vascular smooth muscle cell foam cells are very much defective in their autophagy capacity, and they're very poor effluxes, but we could potentially restore autophagy in the cell population to promote reverse cholesterol transport.   And looking at prevention of atherosclerosis is a bit different than looking at regression, because regression is at a later stage where the plaques are more advanced. And if they're mostly vascular smooth muscle cell-derived, maybe then those drugs that we're considering that protect against the development of atherosclerosis are effective on the macrophage themselves early on, but might not be mimicking what we would see in the clinic where the patients that present are older.   Cindy St. Hilaire:        Yeah, it's kind of really reminiscent of like the CANTOS trial and like, where do we want to target the therapy? It's going to be very different if it's an early smaller plaque, versus a late-stage possibly pro close to rupturing type of plaque. Well, Sabrina Robichaud and Dr Ouimet, thank you so much for joining me today. Congratulations again on a wonderful study, and I'm really looking forward to hearing more about this from your group.   Sabrina Robichaud:    Thank you.   Mireille Ouimet:         Thank you very much. And we also want to thank all the co-authors on the study, specifically also Adil Rasheed, who is co-first author on the work and Katey Rayner's group for all the support and involvement in this study.   Cindy St. Hilaire:        That's it for the highlights from the March issues of Circulation Research. Thank you for listening. Please check out the CircRes Facebook page and follow us on Twitter and Instagram with the handle @circres and #DiscoverCircRes. Thank you to our guests, Sabrina Robichaud and Dr Mireille Ouimet Sabrina. This podcast is produced by Ashara Ratnayaka, edited by Melissa Stoner and supported by the editorial team of Circulation Research. Some of the copy text for highlighted articles was provided by Ruth Williams. I'm your host, Dr Cindy St. Hilaire and this is Discover CircRes, you're on-the-go source for the most up-to-date and exciting discoveries in basic cardiovascular research. This program is copyright of the American Heart Association 2022, The opinions expressed by speakers in this podcast are their own and not necessarily those of the editors or of the American Heart Association. For more information, visit ahajournals.org.