POPULARITY
2 episodes with secreted
2 episodes with secreted
2 episodes with secreted
2 episodes with secreted
2 episodes with secreted
In this encore episode, we detail the intestinal mycobiome and the mechanisms by which beneficial microbes aid in regulating opportunistic fungal species: Candida albicans. We discuss Candida overgrowth virulence and how disruptions in microbial balance, immune function, and epithelial integrity impact Candida's pathogenicity. Additionally, we discuss the role of mast cells in the lamina propria, their involvement in mucosal immunity, and how Mast Cell Activation Syndrome (MCAS) can be exacerbated by fungal dysbiosis / microbial imbalances.Topics: 1. Introduction - The intestinal mycobiome and its role in intestinal health. - Regulating populations of opportunistic fungal species like Candida albicans.- Mast cell activation syndrome (MCAS) intro. 2. Structure of the Intestinal Barrier- The microbiome and mucus layer: microbes, mucins, antimicrobial peptides, sIgA.- The epithelial monolayer: enterocytes, goblet cells, Paneth cells, enteroendocrine cells…- Tight junction proteins and paracellular transport.- The lamina propria beneath the epithelium: immune cells and more. 3. Candida's Pathogenicity and Barrier Disruption- Exists primarily in its yeast form, regulated by microbial competition, host immune defenses, antifungal peptides. - Secretory IgA (sIgA) and immune surveillance mechanisms help regulate fungal populations. - Chronic stress, immune suppression, and dysbiosis can deplete sIgA, increasing susceptibility to Candida proliferation. - Environmental triggers such as immune suppression, microbial depletion, inflammatory cytokines.- Yeast-to-hyphal transition, deeper tissue invasion. - Secreted aspartyl proteinases (SAPs), phospholipases, candidalysin: epithelial damage.- Pattern recognition receptors (PRRs) and overgrowth detection. 4. Impact of Beneficial Bacteria on Candida Overgrowth - Beneficial bacteria compete with Candida for nutrients and epithelial adhesion sites. - Short-chain fatty acids (SCFAs) produced by beneficial bacteria.- Depletion of beneficial bacteria removes ecological resistance, allowing Candida to proliferate unchecked. 5. Mast Cells in the Lamina Propria and Their Role in Intestinal Immunity- Mast cell location - Upon activation, mast cells release histamine, cytokines, proteases, and more that regulate gut immune responses. - Histamine can increase gut permeability and modulate local immune activation. - Tryptase and chymase. - Pro-inflammatory cytokines. 6. Mast Cell Activation Syndrome (MCAS) - Mast cell hyperactivation.- Environmental triggers, toxins, chronic infections, and stress. - Candida overgrowth and mast cell activation.- Addressing microbial imbalances and reducing the body's total microbial, chemical, and toxin burden.- A diverse microbiome. 7. Conclusion- Candida overgrowth and regulation via immune defenses and beneficial bacterial competition.- MCAS, root cause approach.Get Chloe's Book Today! "75 Gut-Healing Strategies & Biohacks" Follow Chloe on Instagram @synthesisofwellnessVisit synthesisofwellness.com
In this episode, we detail the intestinal mycobiome and the mechanisms by which beneficial microbes aid in regulating opportunistic fungal species: Candida albicans. We discuss Candida overgrowth virulence and how disruptions in microbial balance, immune function, and epithelial integrity impact Candida's pathogenicity. Additionally, we discuss the role of mast cells in the lamina propria, their involvement in mucosal immunity, and how Mast Cell Activation Syndrome (MCAS) can be exacerbated by fungal dysbiosis / microbial imbalances.Topics: 1. Introduction - The intestinal mycobiome and its role in intestinal health. - Regulating populations of opportunistic fungal species like Candida albicans.- Mast cell activation syndrome (MCAS) intro. 2. Structure of the Intestinal Barrier- The microbiome and mucus layer: microbes, mucins, antimicrobial peptides, sIgA.- The epithelial monolayer: enterocytes, goblet cells, Paneth cells, enteroendocrine cells…- Tight junction proteins and paracellular transport.- The lamina propria beneath the epithelium: immune cells and more. 3. Candida's Pathogenicity and Barrier Disruption- Exists primarily in its yeast form, regulated by microbial competition, host immune defenses, antifungal peptides. - Secretory IgA (sIgA) and immune surveillance mechanisms help regulate fungal populations. - Chronic stress, immune suppression, and dysbiosis can deplete sIgA, increasing susceptibility to Candida proliferation. - Environmental triggers such as immune suppression, microbial depletion, inflammatory cytokines.- Yeast-to-hyphal transition, deeper tissue invasion. - Secreted aspartyl proteinases (SAPs), phospholipases, candidalysin: epithelial damage.- Pattern recognition receptors (PRRs) and overgrowth detection. 4. Impact of Beneficial Bacteria on Candida Overgrowth - Beneficial bacteria compete with Candida for nutrients and epithelial adhesion sites. - Short-chain fatty acids (SCFAs) produced by beneficial bacteria.- Depletion of beneficial bacteria removes ecological resistance, allowing Candida to proliferate unchecked. 5. Mast Cells in the Lamina Propria and Their Role in Intestinal Immunity- Mast cell location - Upon activation, mast cells release histamine, cytokines, proteases, and more that regulate gut immune responses. - Histamine can increase gut permeability and modulate local immune activation. - Tryptase and chymase. - Pro-inflammatory cytokines. 6. Mast Cell Activation Syndrome (MCAS) - Mast cell hyperactivation.- Environmental triggers, toxins, chronic infections, and stress. - Candida overgrowth and mast cell activation.- Addressing microbial imbalances and reducing the body's total microbial, chemical, and toxin burden.- A diverse microbiome. 7. Conclusion- Candida overgrowth and regulation via immune defenses and beneficial bacterial competition.- MCAS, root cause approach.Thank you to our episode sponsor:1. Shop Fresh Press Farms'Peach Cider Vinegar at Sprouts locations nationwide, and check out their full collection here. Get Chloe's Book Today! "75 Gut-Healing Strategies & Biohacks" Follow Chloe on Instagram @synthesisofwellnessVisit synthesisofwellness.com
This week, we're running through a whole lot of games, since Robin was too busy sleeping on Willa's couch to record last week. First, we cover the most anticipated game of all: Foamstars. Then a demo for a little game called Final Fantasy 7 Rebirth came out, and both of our hosts attended an exciting preview recently, but only one did so well she broke the game. We end with a whole lot of news, only some of which is about how fucked the games industry is!(I also feel compelled to include an extra explicit content warning here for just so, so much talk about bodily fluids in the first five minutes.)Timestamps(01:20) Robin and the City(03:15) The Children of the Bubble(06:40) Kickin' chairs with Cloud(14:00) Willa is too much of a gamer for Unicorn Overlord(33:00) The Game Awards' Non-Evil Twin(37:20) Somehow, Star Wars 1313 returned(40:00) Happy 5th anniversary, Hollow Knight: Silksong!(46:40) Microsoft makes fools of us all(55:20) ZA/UM drama(1:00:00) What else have Willa and Robin been up to this week?Mentioned this weekWho's Telling the Truth about Disco Elysium?These speeches from LarianThe Book of Love reviewZA/UM layoffsThis wild rich lady storyWilla and Robin on Unicorn OverlordMusic Street Food by FASSoundsSend us questions!We stand for a free Palestine, and against the occupation, oppression, and genocide perpetrated against its people.Please consider donating or otherwise standing up to support Palestinians in the wake of Israel's attacks.Medical Aid for PalestianiansPalestine Red Crescent SocietyPalestine Children's Relief FundDemand a ceasefire from your representativesGame Assist's "Gamers for Palestine" resource packetCartoonist Cooperative's e-SIM fundraiser Hosted on Acast. See acast.com/privacy for more information.
Secreted in subterranean slumber, well below the Alps, is said to be a series of ancient humans awaiting the return of a dangerous space enemy. We stumbled upon a rather obscure Italian report that is unlike anything we could have expected. For this episode, we discuss the story of a brilliant Italian engineer who developed an electro-diviner that caught the attention of a secret group intent on steering the course of history. We follow his story involving giant underground spheres, ancient disasters, and more. Then, for our Plus+ members, we embark on a new exploration of strange mutilations and their connections to a deadly occult battle of darkness. Links MU Store Ancients' Awakening: The Archive of the Lost Race Revealed Il risveglio degli Antichi: Rapporto su una civilta' dimenticata dal tempo The Star Mirror: The Cosmic Symmetry of Heaven and Earth The Kingdom of Agarttha: A Journey into the Hollow Earth 26.22 - MU Plus+ Podcast - Star Mirror The Lord of the World: What's Really Behind the Legend of the Mysterious Kingdom of Agarttha? Plus+ Extension The extension of the show is EXCLSUIVE to Plus+ Members. To join, click HERE. Luis Burgos Inexplicata Extra-Terrestrials Among Us An Alien Harvest: Further Evidence Linking Animal Mutilations and Human Abductions to Alien Life Forms Learn more about your ad choices. Visit megaphone.fm/adchoices
In which we throw a whole bunch of shiny new Keyblades in the trash and talk about bosses. Drop us a question, comment, or pontification on the nature of the heart! Email us at khbhpodcast@gmail.com --- Send in a voice message: https://podcasters.spotify.com/pod/show/kingdomheartsbyheart/message Support this podcast: https://podcasters.spotify.com/pod/show/kingdomheartsbyheart/support
References Journal of Experimental & Clinical Cancer Research 2022.volume 41, Article number: 303. Protein Cell. 2021 Apr; 12(4): 240–260. J Cell Biol (2022) 221 (11): e202202011. --- Send in a voice message: https://podcasters.spotify.com/pod/show/dr-daniel-j-guerra/message
Welcome to Campfire Classics, a Literary Comedy Podcast!! This week, we are down with the Flipper Dipper Dip. Apparently... Whatever that means... Okay, that's the niceties out of the way. Today, Ken has chosen a story for Heather by pulp author Randall Garrett. It is called "The Time Snatcher". And for some reason Heather has chosen this week to see how many accents she can fit into one hour. Good luck everyone. Your talking points include blackmailing Robert Zemeckis, pickup lines that work...kinda, and a tightly guarded erection. "The Time Snatcher" was published in Imagination Stories of Science and Fantasy in February 1957, extensive research has uncovered no evidence of an active copyright. Email us at 5050artsproduction@gmail.com. Remember to tell five friends to check out Campfire Classics. Like, subscribe, leave a review. Now sit back, light a fire (or even a candle), grab a drink, and enjoy.
Link to bioRxiv paper: http://biorxiv.org/cgi/content/short/2023.04.03.535448v1?rss=1 Authors: Irala, D., Wang, S., Sakers, K., Nagendren, L., Ulloa-Severino, F. P., Bindu, D. S., Eroglu, C. Abstract: Astrocytes strongly promote the formation and maturation of synapses by secreted proteins. To date, several astrocyte-secreted synaptogenic proteins controlling different stages of excitatory synapse development have been identified. However, the identities of astrocytic signals that induce inhibitory synapse formation remain elusive. Here, through a combination of in vitro and in vivo experiments, we identified Neurocan as an astrocyte-secreted inhibitory synaptogenic protein. Neurocan is a chondroitin sulfate proteoglycan that is best known as a protein localized to the perineuronal nets. However, Neurocan is cleaved into two after secretion from astrocytes. We found that the resulting N- and C- terminal fragments have distinct localizations in the extracellular matrix. While the N-terminal fragment remains associated with perineuronal nets, the Neurocan C-terminal fragment localizes to synapses and specifically controls cortical inhibitory synapse formation and function. Neurocan knockout mice lacking the whole protein or only its C-terminal synaptogenic region have reduced inhibitory synapse numbers and function. Through super-resolution microscopy and in vivo proximity labeling by secreted TurboID, we discovered that the synaptogenic domain of Neurocan localizes to somatostatin-positive inhibitory synapses and strongly regulates their formation. Together, our results unveil a mechanism through which astrocytes control circuit-specific inhibitory synapse development in the mammalian brain. Copy rights belong to original authors. Visit the link for more info Podcast created by Paper Player, LLC
(Pillow Talk Ep: 4) Topics: "Vabbing" aka Pu**y Juice Aphrodisiac Perfume, Late-Nite Edition™Filmed Edition: https://youtu.be/jFGPlqesv3oL35 opens 2023 with a late-nite themed episode centered around erotic perfumes and pheromones; concludes with a conversation about PH balance and tickling a man's fancy. Palace Members featured:*Ladies 35 Podcast*Nola
If you haven't seen the stunning cover of The Rose and the Thistle by Laura Frantz yet, I feel like I should ask if you've been feeling okay. It's been everywhere, and I've been drooling. So when I saw that I was going to get to chat with Laura about this book, let's just say I was a wee bit excited. I mean... Scotland. Jacobite Rebellion. What's not to love? Listen in to all about Everard (did you see that name!) and Blythe's story and the upcoming novels as well! Note: links may be affiliate links that provide me with a small commission at no extra expense to you. What Happens When You Throw an English Beauty into the Jacobite Rebellion? Beloved author of books like The Lacemaker and Courting Morrow Little, Laura Frantz writes a lot of historical fiction in colonial America, but as with her most recent release, she's also dipping her toe into the other side of the pond in Scotland as well. Laura and I chatted about where the idea for The Rose and the Thistle came from (her family history inspired some of it!) came from, how one of the characters has the name of her first "boyfriend," and even compared the Presbyterian persecution of Catholics in early eighteenth-century Scotland with the Catholic persecution of the Huguenots in France. We got a glimpse of her next book (about the Canadian Acadians!) as well as word that she's five chapters into another book set in Scotland. EEEP! I'm so excited for both of them. Let's just say I have my reading cut out for me! For readers looking for which books to try next while waiting for her next book, Laura Frantz recommends those two books above. The Lacemaker (if you're looking for a more genteel story) or Courting Morrow Little (if you want something more frontier). Oh, and I said someone recommended it? I think it might have been Pegg Thomas! The Rose and the Thistle by Laura Frantz In 1715, Lady Blythe Hedley's father is declared an enemy of the British crown because of his Jacobite sympathies, forcing her to flee her home in northern England. Secreted to the tower of Wedderburn Castle in Scotland, Lady Blythe awaits who will ultimately be crowned king. But in a house with seven sons and numerous servants, her presence soon becomes known. No sooner has Everard Hume lost his father, Lord Wedderburn, than Lady Hedley arrives with the clothes on her back and her mistress in tow. He has his own problems--a volatile brother with dangerous political leanings, an estate to manage, and a very young brother in need of comfort and direction in the wake of losing his father. It would be best for everyone if he could send this misfit heiress on her way as soon as possible. Drawn into a whirlwind of intrigue, shifting alliances, and ambitions, Lady Blythe must be careful whom she trusts. Her fortune, her future, and her very life are at stake. Those who appear to be adversaries may turn out to be allies--and those who pretend friendship may be enemies. You can learn more about this book and upcoming books on Laura's WEBSITE. AND!!! Laura's book IS 30% off with FREE shipping! So if you want to grab one o those other books with free shipping, you can probably get two for about twenty-five dollars... with free shipping! Here's a LINK! Like to listen on the go? You can find Because Fiction Podcast at: Apple Castbox Google Play Libsyn RSS Spotify Stitcher Amazon and more!
In this episode, we talk about a paper in Austria titled, SVF-derived extracellular vesicles carry characteristic miRNAs in lipedema.
Christian Historical Fiction Talk is listener supported. When you buy things through this site, we may earn an affiliate commission.Become a patron and enjoy special perks and bonus content.Laura Frantz and I had a fabulous chat on this week's episode. Her new book, The Rose and the Thistle, is set in 1715 in Scotland and pits a Jacobite against a Hanoverian. She does a great job of explaining what all that means, how Christian fiction has changed enough to allow her to write a book like this, and how fabulous her trip to her ancestral home in the lowlands of Scotland was. This is an episode you don't want to miss. The Rose and the Thistle by Laura FrantzIn 1715, Lady Blythe Hedley's father is declared an enemy of the British crown because of his Jacobite sympathies, forcing her to flee her home in northern England. Secreted to the tower of Wedderburn Castle in Scotland, Lady Blythe awaits who will ultimately be crowned king. But in a house with seven sons and numerous servants, her presence soon becomes known.No sooner has Everard Hume lost his father, Lord Wedderburn, than Lady Hedley arrives with the clothes on her back and her mistress in tow. He has his own problems--a volatile brother with dangerous political leanings, an estate to manage, and a very young brother in need of comfort and direction in the wake of losing his father. It would be best for everyone if he could send this misfit heiress on her way as soon as possible.Drawn into a whirlwind of intrigue, shifting alliances, and ambitions, Lady Blythe must be careful whom she trusts. Her fortune, her future, and her very life are at stake. Those who appear to be adversaries may turn out to be allies--and those who pretend friendship may be enemies.Get your copy of The Rose and the Thistle by Laura Frantz.Meet Laura FrantzAward-winning, bestselling author Laura Frantz is passionate about all things historical, particularly the 18th-century, and writes her manuscripts in longhand first. Her stories often incorporate Scottish themes that reflect her family heritage. She is a direct descendant of George Hume, Wedderburn Castle, Berwickshire, Scotland, who was exiled to the American colonies for his role in the Jacobite Rebellion of 1715, settled in Virginia, and is credited with teaching George Washington surveying. Proud of her heritage, she is also a member of the Daughters of the American Revolution.According to Publishers Weekly, “Frantz has done her historical homework.” With her signature attention to historical detail and emotional depth, she is represented by Janet Kobobel Grant, Literary Agent & Founder, Books & Such Literary Agency of Santa Rosa, California.Visit Laura's website.
Link to bioRxiv paper: http://biorxiv.org/cgi/content/short/2022.12.16.520775v1?rss=1 Authors: Perron, C., Carme, P., Llobet Rosell, A., Minnaert, E., Ruiz Demoulin, S., Szczkowski, H., Neukomm, L. J., Dura, J.-M., Boulanger, A. Abstract: During animal development, neurons often form exuberant or incorrect axons and dendrites at early stages, followed by the refinement of neuronal circuits at late stages. Neural circuit refinement leads to the production of large amounts of neuronal debris in the form of neuronal cell corpses, fragmented axons and dendrites, and pruned synapses requiring disposal. In particular, the predominant phagocytes acting during the neuronal remodeling and degeneration are glial cells and critical signaling pathways between neurons and glia leading to phagocytosis are required. Chemokine-like mushroom body neuron secreted Orion ligand was shown to be essential to the astrocyte infiltration into the {gamma} axon bundle leading to {gamma} axon pruning and clearance of debris left from axon fragmentation. Here we show a role of orion also in debris engulfment and phagocytosis. Interestingly, we show that orion is also involved in the overall transformation of astrocytes into phagocytes. In addition, analysis of several neuronal paradigms demonstrates the role of orion in the elimination of both peptidergic vCrz+ and PDF-Tri neurons via additional phagocytic glial cells as cortex and/or ensheathing glia. Our results suggest that Orion is essential for phagocytic activation of three different types of glial cells: astrocytes, cortex and ensheathing glia and point to Orion as a trigger not only of glial infiltration but also engulfment and phagocytosis. Copy rights belong to original authors. Visit the link for more info Podcast created by Paper Player, LLC
Link to bioRxiv paper: http://biorxiv.org/cgi/content/short/2022.12.06.519254v1?rss=1 Authors: Hubmacher, D., Taye, N., Baldock, C., Singh, M. Abstract: The formation of multinucleated contractile myofibers from muscle stem cells during myogenesis is indispensable for skeletal muscle formation. Myogenesis is governed by myogenic regulatory transcription factors, including MYOD. However, very few MYOD-regulated effector proteins were shown to be sufficient to promote myogenesis. Here, we identified an unexpected role for the secreted matricellular protein ADAMTS-like 2 (ADAMTSL2) as a rheostat for Wnt signaling during myogenesis downstream of MYOD. ADAMTSL2 expression was induced during myoblast differentiation and ADAMTSL2 was required for myoblast differentiation. ADAMTSL2 ablation in myogenic precursor cells resulted in aberrant muscle architecture in vivo. The pro-myogenic ADAMTSL2 function was dependent on WNT ligands. Mechanistically, ADAMTSL2 potentiated WNT signaling by binding to WNT ligands and WNT receptors. Finally, we identified a WNT-binding ADAMTSL2 peptide that was sufficient to promote myogenesis. Since ADAMTSL2 was previously described as a negative regulator of TGF{beta} signaling in fibroblasts, ADAMTSL2 now emerges as a signaling node that could integrate and fine-tune WNT, TGF{beta} and potentially other signaling pathways within the dynamic microenvironment of differentiating myoblasts during skeletal muscle development and regeneration. Copy rights belong to original authors. Visit the link for more info Podcast created by Paper Player, LLC
Link to bioRxiv paper: http://biorxiv.org/cgi/content/short/2022.12.01.518726v1?rss=1 Authors: Vorstandlechner, V., Copic, D., Klas, K., Direder, M., Golabi, B., Radtke, C., Ankersmit, H. J., Mildner, M. Abstract: Background Hypertrophic scars can cause pain, movement restrictions, and reduction of quality of life. Despite numerous options to tackle hypertrophic scarring, efficient therapies are still scarce, and cellular mechanisms are not well understood. Secreted factors from peripheral blood mononuclear cells (PBMCsec) were previously described for their beneficial effects in tissue regeneration. Here, we investigated the effects of PBMCsec on skin scarring in mouse models and human scar explant cultures at single cell resolution (scRNAseq). Methods Mouse wounds and scars were treated with PBMCsec either intradermally or topically. Human mature scars were treated with PBMCsec ex vivo in explant cultures. All experimental settings were analyzed by single cell RNA sequencing (scRNAseq). A variety of bioinformatics approaches were used to decipher gene regulation in the scRNAseq data sets. Components of the extracellular matrix (ECM) were investigated in situ by immunofluorescence. The effect of PBMCsec on myofibroblast differentiation and elastin expression was investigated by stimulating human primary fibroblasts with TGF{beta}. Findings Topical and intradermal application of PBMCsec regulated the expression of a variety of genes involved in pro-fibrotic processes and tissue remodeling. Our bioinformatics approach identified elastin as a common linchpin of antifibrotic action in both, the mouse and human experimental setting. In vitro, we found that PBMCsec prevents TGF{beta}-mediated myofibroblast-differentiation and attenuates abundant elastin expression through non-canonical signaling inhibition. Furthermore, TGF{beta}-induced breakdown of elastic fibers was strongly inhibited by addition of PBMCsec. Interpretation Together, we showed anti-fibrotic effect of PBMCsec on cutaneous scars in mouse and human experimental settings, suggesting PBMCsec as a novel therapeutic option to treat skin scarring. Copy rights belong to original authors. Visit the link for more info Podcast created by Paper Player, LLC
A new research paper was published on the cover of Aging (listed as "Aging (Albany NY)" by Medline/PubMed and "Aging-US" by Web of Science) Volume 14, Issue 20, entitled, “Downregulation of senescence-associated secretory phenotype by knockdown of secreted frizzled-related protein 4 contributes to the prevention of skin aging.” There is growing evidence that the appearance and texture of the skin that is altered during the aging process are considerably enhanced by the accumulation of senescent dermal fibroblasts. These senescent cells magnify aging via an inflammatory, histolytic, and senescence-associated secretory phenotype (SASP). Secreted frizzled-related protein 4 (SFRP4) was previously determined to be expressed in dermal fibroblasts of aging skin, and its increased expression has been shown to promote cellular senescence. However, its role in the SASP remains unknown. In this new study, researchers Kento Takaya, Toru Asou and Kazuo Kishi from Keio University School of Medicine's Department of Plastic and Reconstructive Surgery investigated the classical model of skin fibroblasts based on Hayflick's mitotic limit, the observation of SFRP4 expression in replicating senescent cells, and the effect of regulating this on the suppression of SASP and aging skin. “These results may contribute to the development of new therapies to ameliorate skin aging.” The researchers found that SFRP4 was significantly expressed in p16ink4a-positive human skin fibroblasts and that treatment with recombinant SFRP4 promoted SASP and senescence, whereas siRNA knockdown of SFRP4 suppressed SASP. They also found that knockdown of SFRP4 in mouse skin ameliorates age-related reduction of subcutaneous adipose tissue, panniculus carnosus muscle layer, and thinning and dispersion of collagen fibers. These findings suggest a potential candidate for the development of new skin rejuvenation therapies that suppress SASP. “This study shows that SFRP4, which is specifically expressed in aged p16ink4a-positive skin fibroblasts, contributes to SASP, and that treatment with SFRP4 causes worsening of this phenotype. To the best of our knowledge, the present study is the first to report that the suppression of SFRP4 expression in vivo ameliorates skin aging-related phenotypes, that is, adipose tissue atrophy and collagen fiber thinning, via SASP suppression.” DOI: https://doi.org/10.18632/aging.204273 Corresponding Author: Kento Takaya - Email: kento-takaya312@keio.jp Keywords: skin, fibroblast, SASP, SFRP4 Sign up for free Altmetric alerts about this article: https://aging.altmetric.com/details/email_updates?id=10.18632%2Faging.204273 About Aging-US: Launched in 2009, Aging (Aging-US) publishes papers of general interest and biological significance in all fields of aging research and age-related diseases, including cancer—and now, with a special focus on COVID-19 vulnerability as an age-dependent syndrome. Topics in Aging go beyond traditional gerontology, including, but not limited to, cellular and molecular biology, human age-related diseases, pathology in model organisms, signal transduction pathways (e.g., p53, sirtuins, and PI-3K/AKT/mTOR, among others), and approaches to modulating these signaling pathways. Please visit our website at www.Aging-US.com and connect with us: SoundCloud – https://soundcloud.com/Aging-Us Facebook – https://www.facebook.com/AgingUS/ Twitter – https://twitter.com/AgingJrnl Instagram – https://www.instagram.com/agingjrnl/ YouTube – https://www.youtube.com/agingus LinkedIn – https://www.linkedin.com/company/aging/ Reddit – https://www.reddit.com/user/AgingUS Pinterest – https://www.pinterest.com/AgingUS/ For media inquiries, please contact media@impactjournals.com. Aging (Aging-US) Journal Office 6666 E. Quaker Str., Suite 1B Orchard Park, NY 14127 Phone: 1-800-922-0957, option 1
We would like to thank the sponsor of this episode, BTG Speciality Pharmaceuticals. BTG provides rescue medicines typically used in emergency rooms and intensive care units to treat patients for whom there are limited treatment options. They are dedicated to delivering quality medicines that make a real difference to patients and their families through the development, manufacture, and commercialization of pharmaceutical products. Their current portfolio of antidotes counteracts certain snake venoms and the toxicity associated with some heart and cancer medications. Their drug, Voraxaze, is for high-dose methotrexate toxicity. --- Dr. Nancy DeMore is a board-certified breast surgical oncologist and is the BMW endowed chair in cancer research at MUSC Health. Dr. DeMore obtained her medical degree from Chicago Medical School. She completed her residency at Boston University Medical Center, a cancer research fellowship at Harvard Medical School, and fellowship training at Memorial Sloan Kettering Cancer Center. Dr. DeMore practiced as a professor of surgery at the University of North Carolina-Chapel Hill for 13 years. --- What We Do at MIB Agents: PROGRAMS: ✨ End-of-Life MISSIONS ✨ Gamer Agents ✨ Agent Writers ✨ Prayer Agents ✨ Healing Hearts - Bereaved Parent Support ✨ Ambassador Agents - Peer Support ✨ Warrior Mail ✨ Young Adult Survivorship Support Group ✨ EDUCATION for physicians, researchers and families: ✨ OsteoBites, weekly webinar & podcast with thought leaders and innovators in Osteosarcoma ✨ MIB Book: Osteosarcoma: From our Families to Yours ✨ RESEARCH: Annual MIB FACTOR Research Conference ✨ Funding $100,000 annually for OS research ✨ MIB Testing & Research Directory ✨ The Osteosarcoma Project partner with Broad Institute of MIT and Harvard ... Kids are still dying with 40+ year old treatments. Help us MakeItBetter.
Simon's live chat with James O'Brien on the UK's LBC.
Welcome to the Instant Trivia podcast episode 395, where we ask the best trivia on the Internet. Round 1. Category: Also A Weather Term 1: To welcome, or to order a cab. hail. 2: Usual noun for what appears on a TV with bad reception. snow. 3: Trumpets, trombones and flutes are grouped as this type of instrument. winds. 4: If you're "on" one, you're in high spirits; if you're "under" one, you're in disgrace. a cloud. 5: If you "steal someone's" this, you've ruined the effect of a remark by anticipating it. thunder. Round 2. Category: People Eat That? 1: The cheeks of this animal can be smoked, as its belly is smoked for bacon. Pig. 2: Mold gives this type of colorful cheese, like Roquefort, its flavor. Blue cheese. 3: These fleshy growths that top roosters' heads are blanched, dipped in batter and fried for use as a garnish. combs. 4: Secreted by sperm whales and found in perfume, this waxy substance is used as a spice in the East. ambergris. 5: Tripe is the lining of this digestive organ of cattle. Stomach. Round 3. Category: Science Stuff 1: It's the only calendar month that can go without a full moon. February. 2: Ventifacts are rocks that are shaped by sand driven by this force of nature. Wind. 3: Prone to volcanoes and earthquakes, the "Ring of Fire" borders this ocean. Pacific Ocean. 4: Hematite is an important ore of this metal. Iron. 5: Unwelcome in basements, this radioactive element is the heaviest of the noble gases. Radon. Round 4. Category: Mergers And Acquisitions 1: In an $80 billion deal these 2 oil companies joined forces in 1999 in the biggest merger up to that time. Exxon and Mobil. 2: In 2004 this Dutch airlines merged with Air France. KLM. 3: In 1999 Ford snatched up the auto unit of this company for 50 billion kronor. Volvo. 4: In 2004 FedEx acquired this chain of stores, and you can copy me on that!. Kinko's. 5: Despite opposition from the 2 founders' families, this company merged with Compaq in 2002. Hewlett-Packard. Round 5. Category: Don't Pick Me! 1: The card you don't want to pick in this children's game is the odd queen. Old Maid. 2: A sign on the road to Carlsbad Caverns reads, "Do not pick up" these; "prison facilities in this area". hitchhikers. 3: It's the crust of fibrin and serum that forms on a wound and then dries. a scab. 4: After 5 Emmys, this "Murphy Brown" star took herself out of the running for 1996 to give others a chance. Candice Bergen. 5: The robber hopes his victim doesn't pick him out of this police parade of prisoners. a lineup. Thanks for listening! Come back tomorrow for more exciting trivia!
Rosa and Dash are back it again to encourage you not to do crypto
Malta has become the first European Union country to legalise cannabis at home and for personal use. MPs approved a legal reform on Tuesday, allowing citizens to grow and possess limited amounts of marijuana. Under the new law, citizens aged 18 and over will be allowed to possess up to seven grams of cannabis, and cultivate up to four cannabis plants at home. Grey amber or whale poo is worth more than its weight in gold, the 1.7 kilogram chunk being worth an estimated €80,000....... Spanish law prohibits the marketing of grey amber, who have sent it to a laboratory for authentication. ..... Secreted by sperm whales when they suffer digestive problems, grey amber is highly prized as a perfume fixative. UK and Spanish Foreign Ministers expected to discuss shared priorities, such as combatting malign actors and getting more girls into education. Foreign Secretary to boost economic ties as she hosts an event with leading Spanish investors and British businesses A controversial Spanish bishop has been formally stripped of his church powers after abandoning his clerical carer to marry a novelist known for her transgressive erotic novels, some of which contains references to Satanism. Xavier Novell i Gomà was Spain's youngest ever bishop when he was appointed to the Catalan municipality of Solsona in 2010, aged just 41.
SPAIN must urgently change its rules on how much British pensioners need to earn to live there or its economy will suffer badly, a leading ex-pat said to The Express. Speaking from the Expat Centre in Costa Blanca South, Moira Carmenate said she was “surprised” that Spain hadn't dropped its requirement for pensioners to prove an annual earning of more than £21,000 (€24,697). Malta has become the first European Union country to legalise cannabis at home and for personal use. MPs approved a legal reform on Tuesday, allowing citizens to grow and possess limited amounts of marijuana. Under the new law, citizens aged 18 and over will be allowed to possess up to seven grams of cannabis, and cultivate up to four cannabis plants at home. Grey amber or whale poo is worth more than its weight in gold, the 1.7 kilogram chunk being worth an estimated €80,000....... Spanish law prohibits the marketing of grey amber, who have sent it to a laboratory for authentication. ..... Secreted by sperm whales when they suffer digestive problems, grey amber is highly prized as a perfume fixative.
High Elves. Wood Elves. Sea Elves. Dark Elves. It seems everywhere you look these days, there's another elf. What if everything worked this way, and if you lived somewhere soon your physiology would adapt to the area? Kevin and Jeremy find out.
High Elves. Wood Elves. Sea Elves. Dark Elves. It seems everywhere you look these days, there's another elf. What if everything worked this way, and if you lived somewhere soon your physiology would adapt to the area? Kevin and Jeremy find out.
Commentary by Dr. Valentin Fuster
Welcome to the Instant Trivia podcast episode 4, where we ask the best trivia on the Internet. Round 1. Category: People Eat That? 1: This snake-like fish can often be found in sushi. Eel. 2: The book "Fashionable Food" tells how to make a "truly awful" salad with a banana and this cinema snack. popcorn. 3: Witchetty grubs are large insect larvae savored ( and named) by this country's Aborigines. Australia. 4: Secreted by sperm whales and found in perfume, this waxy substance is used as a spice in the East. ambergris. 5: Tripe is the lining of this digestive organ of cattle. Stomach. Round 2. Category: Current Sitcoms 1: A Vermont innkeeper in his last series, this veteran comedian now plays cartoonist Bob McKay. Bob Newhart. 2: Now in its 7th season, this sitcom about the Bundys is Fox's longest-running series. Married... with Children. 3: On "Love and War", Jay Thomas wants this former "L.A. Law" star to warm up his nights. Susan Dey. 4: She's back, she's blonde and she has designs on becoming a country star on her new sitcom. Delta Burke. 5: It's the name of the newsmagazine show for which Murphy Brown works. FYI. Round 3. Category: Hey "Ya" 1: More than 345 million individuals each month hit this website. Yahoo!. 2: A skullcap worn during prayer by Jewish men. yarmulke. 3: 3-word nonsense term meaning " and so on" once featured in a popular sitcom. yada yada yada. 4: "Barbaric" often precedes this word derived from Middle English meaning "harsh cry". yawp. 5: Slang word for a convict, or a Charlie Parker nickname. yardbird. Round 4. Category: Native American Place Names 1: Moving right along--this large Alabama city, as well as a river and bay, was named for an Indian tribe in the region. Mobile. 2: This New York island is named for the Indians who sold it to Peter Minuit in 1626. Manhattan. 3: "Buffalo Fish and Tyler Too" doesn't sound quite as poetic as this Indian name for the river. Tippecanoe. 4: Although its name means "place of sandflies", we associate this Pennsylvania borough with groundhogs. Punxsutawney. 5: You'd have a whale of a good time visiting this Massachusetts island whose name may mean "the faraway land". Nantucket. Round 5. Category: Tv Drama 1: (VIDEO DAILY DOUBLE):(Hi, I'm Ollie North, and)I've played a mysterious intelligence operative named Ollie on 2 episodes of this CBS series about naval lawyers. "JAG". 2: Della Reese has won 3 NAACP Image Awards as outstanding lead actress for playing Tess on this series. "Touched By An Angel". 3: In 1994-95 this medical series finished second in the ratings, the highest ever for a first-year drama series. "ER". 4: This NBC crime drama is the 1st TV drama series executive produced by film director Barry Levinson. "Homicide: Life On The Street". 5: Tom Hanks was the executive producer of this 1998 HBO miniseries about the Apollo space program. "From The Earth To The Moon". Thanks for listening! Come back tomorrow for more exciting trivia!
Link to bioRxiv paper: http://biorxiv.org/cgi/content/short/2020.11.09.374306v1?rss=1 Authors: Mazuir, E., Richevaux, L., Nassar, M., Robil, N., de la Grange, P., Lubetzki, C., Fricker, D., Sol-Foulon, N. Abstract: Oligodendrocytes form myelin for central nervous system axons and release factors which signal to neurons during myelination. Here, we ask how oligodendroglial factors influence hippocampal GABAergic neuron physiology. In mixed hippocampal cultures GABAergic neurons fired action potentials of short duration and received high frequencies of excitatory synaptic events. In purified neuronal cultures without glial cells, GABAergic neuron excitability increased and the frequency of synaptic events decreased. These effects were largely reversed by adding oligodendrocyte conditioned medium. We compared the transcriptomic signature with the electrophysiological phenotype of single neurons in these three culture conditions. Genes expressed by single pyramidal or GABAergic neurons largely conformed to expected cell-type specific patterns. Multiple genes of GABAergic neurons were significantly downregulated by the transition from mixed cultures containing glial cells to purified neuronal cultures. Levels of these genes were restored by the addition of oligodendrocyte conditioned medium to purified cultures. Clustering genes with similar changes in expression between different culture conditions revealed processes affected by oligodendroglial factors. Enriched genes are linked to roles in synapse assembly, action potential generation and transmembrane ion transport, including of zinc. These results provide new insight into the molecular targets by which oligodendrocytes influence neuron excitability and synaptic function. Copy rights belong to original authors. Visit the link for more info
This is an old episode from last season but i fucking hate tue Jizz Stain so much i want to replay some of her most vile of moments so any simmering hatred the audience has for her is stoked and burns brightly once again. Never forget and Never give up. If we shout loud enough the Jizz Stain will be eradicated. God, i hate that bitch......"Yes, my son....i know. I agree." Thanks God! 'No worries".
Link to bioRxiv paper: http://biorxiv.org/cgi/content/short/2020.10.16.341644v1?rss=1 Authors: Lantoine, J., Proces, A., Villers, A., Halliez, S., Buee, L., Ris, L., Gabriele, S. Abstract: Traumatic brain injury (TBI) remains one of the leading causes of mortality and morbidity worldwide. Despite its high prevalence and extensive efforts to develop neuroprotective therapies, effective treatments for TBI are still limited. Among important neuronal damages, TBI induces structural and functional alterations of astrocytes, the most abundant cell type in the brain. Injured astrocytes respond in diverse mechanisms that result in reactive astrogliosis and are involved in the physiopathological mechanisms of TBI in an extensive and sophisticated manner. The establishment of effective neuroprotective treatments for TBI requires to better understand the complex biochemical interactions between activated astrocytes and neurons that contribute to the secondary injury. To address this challenge, we studied in vitro the role of mechanically injured astrocytes on the growth and synaptic connections of cortical neuronal networks of controlled architectures grown on well-defined protein micropatterns. Astrocytes were cultivated on elastic membranes and mechanically activated by stretching cycles. The culture media of healthy or activated astrocytes was then introduced on neuronal networks. We analyzed the neuronal viability, the neurite growth and the synaptic density of neuronal networks to understand the role of the inflammatory molecules secreted by mechanically activated astrocytes. Furthermore, we cultivated neuronal networks during 13 days with different doses of TNF- in order to decipher its individual contribution among the other cytokines. Here we show that the ratio of tubulin to synapsin area was significantly higher in neuronal networks treated with either 4 or 2 doses of TNF-, suggesting that TNF- can promote the tubulin polymerization process. Assuming that TNF- can bind to either TNFR1 or TNFR2 receptors, which lead respectively to the cell survival or the cell apoptosis, we studied the modulation of the both TNF- receptors in response to the medium of mechanically activated astrocytes and different doses of TNF-. Our findings indicate that the amount of both receptors increases with the maturation of the network. In addition, we observed a significant modulation of the amount of TNFR1 and TNFR2 in response to the media of injured astrocytes that leads to a large imbalance between both receptors, suggesting an important role for TNF-signaling in the physiopathological mechanisms of TBI. Copy rights belong to original authors. Visit the link for more info
The cover for issue 40 of Oncotarget features Figure 5, "miR-210 silences the proapoptosis member CASP8AP2," by Kling, et al. which reported that hypoxic Ewing's sarcoma cells release exosomes that promote sphere formation, a stem-like phenotype, in EWS cells by enhancing survival. Analysis of the hypoxic exosomal miRNA cargo identified a HIF-1α regulated miRNA, miR-210, as a potential mediator of sphere formation in cells exposed to hypoxic exosomes. The knockdown of HIF-1α in hypoxic EWS cells led to decreased exosomal miR-210 levels and reduced the capacity of hypoxic exosomes to form spheres. Inhibition of miR-210 in hypoxic spheres attenuated sphere formation and overexpression of miR-210 in normoxic spheres significantly enhanced the number of EWS spheres. Together, the findings in this Oncotarget study suggest that hypoxic exosomes promote stemness in EWS cells by delivering enriched miR-210 that is capable of down-regulating apoptotic pathways, resulting in the survival of cells with increased sphere formation. Dr. Shantaram S. Joshi from The University of Nebraska Medical Center said, "Ewing's sarcoma (EWS) is an aggressive and highly malignant bone tumor that develops in children and adolescents." HIF -1α has been demonstrated to regulate tumor formation and stem cell survival in hypoxic cancer cells by inhibiting apoptosis. Emerging evidence indicates intercellular communication between tumor cells in hypoxic and normoxic regions contributes to functional differences associated with hypoxic tumors. Other reports demonstrated that shCD99 EWS-derived exosomes could transfer enriched miR-34a to recipient EWS cells and stimulate neural differentiation while in another study, EWS-derived exosomes carrying EZH2 mRNA could be delivered intact to mesenchymal stem cells. Studies in other cancer models investigating the role of hypoxic exosomes have provided insight into how hypoxic tumors can secrete exosomes that propagate an aggressive phenotype in cells outside the hypoxic niche. Exosomes released from hypoxic prostate cancer cells enhanced sphere formation in normoxic cells, but the authors were unable to elucidate a mechanism describing how hypoxic exosomes promote stemness in normoxic cells. The Joshi Research Team concluded in their Oncotarget Research Paper that this study describes a mechanism whereby EWS cells under hypoxic conditions release exosomes that enhance stemness in EWS cells. The authors identified a hypoxia regulated miRNA significantly expressed in hypoxic cells and HypoxicEXO and characterized a potential target that facilitates an apoptotic pathway critical to sphere formation. Ongoing studies are investigating the role of HIF-1α on regulating EWS stemness and together, the authors future aim is to investigate how HIF-1α selectively modulates the packaging of miRNAs into HypoxicEXO, and validate additional miRNAs that promote aggressive hypoxic phenotypes. Sign up for free Altmetric alerts about this article DOI - https://doi.org/10.18632/oncotarget.27702 Full text - https://www.oncotarget.com/article/27702/text/ Correspondence to - Shantaram S. Joshi - ssjoshi@unmc.edu Keywords - exosomes, hypoxia, Ewing's sarcoma, stemness, miR-210 About Oncotarget Oncotarget is a weekly, peer-reviewed, open access biomedical journal covering research on all aspects of oncology. To learn more about Oncotarget, please visit https://www.oncotarget.com or connect with: SoundCloud - https://soundcloud.com/oncotarget Facebook - https://www.facebook.com/Oncotarget/ Twitter - https://twitter.com/oncotarget LinkedIn - https://www.linkedin.com/company/oncotarget Pinterest - https://www.pinterest.com/oncotarget/ Reddit - https://www.reddit.com/user/Oncotarget/ Oncotarget is published by Impact Journals, LLC please visit http://www.ImpactJournals.com or connect with @ImpactJrnls Media Contact MEDIA@IMPACTJOURNALS.COM 18009220957x105
Link to bioRxiv paper: http://biorxiv.org/cgi/content/short/2020.08.31.275552v1?rss=1 Authors: Rogulja, D., Titos, I. Abstract: Since sensory information is always present in the environment, animals need to internally regulate their responsiveness to fit the context. During sleep, the threshold for sensory arousal is increased so that only stimuli of sufficient magnitude can cross it. The mechanisms that make arousability flexible are largely mysterious, but they must integrate sensory information with information about physiology. We discovered a gut-to-brain signaling pathway that uses information about ingested nutrients to control arousability from sleep, without affecting sleep duration. Protein ingestion causes endocrine cells in the Drosophila gut to increase production of CCHa1, a peptide that decreases sensory responsiveness. CCHa1 is received by a small group of brain dopaminergic neurons whose activity gates behavioral responsiveness to mechanical stimulation. These dopaminergic neurons innervate the mushroom body, a brain structure involved in determining sleep duration. This work describes how the gut tunes arousability according to nutrient availability, allowing deeper sleep when dietary proteins are abundant. It also suggests that behavioral flexibility is increased through independent tuning of sleep depth and duration. Copy rights belong to original authors. Visit the link for more info
Link to bioRxiv paper: http://biorxiv.org/cgi/content/short/2020.08.07.224964v1?rss=1 Authors: El Atab, O., Darwiche, R., Truax, N. J., Schneiter, R., Hull, K. G., Romo, D., Asojo, O. A. Abstract: During their infective stages, hookworms release excretory-secretory (E-S) products, including small molecules and proteins, to help evade and suppress the host immune system. Small molecules found in E-S products of mammalian hookworms include nematode derived metabolites like ascarosides, which are composed of the sugar ascarylose linked to a fatty acid side chain. Ascarosides play vital roles in signaling, development, reproduction, and survival. The most abundant proteins found in hookworm E-S products are members of the protein family known as Ancylostoma secreted protein (ASP). ASP belongs to the SCP/TAPS (sperm-coating protein / Tpx / antigen 5 / pathogenesis related-1 / Sc7) superfamily of proteins, members of which have previously been shown to bind to eicosanoids and fatty acids. These molecules are structurally similar to the fatty acid moieties of ascarosides. The objective of this study was to determine if the hookworm ASP; N. americanus Ancylostoma secreted protein 2 (Na-ASP-2) binds to the ascarosides or their fatty acid moieties. We describe investigations of our hypothesis that there is a functional relationship between the major secreted proteins and signaling small molecules found in hookworm E-S products. To accomplish this, several ascarosides and their fatty acid moieties were synthesized and tested for in vitro binding to Na-ASP-2 using a ligand competition assay and microscale thermophoresis. Our results reveal that the fatty acid moieties of the ascarosides, bind specifically to the palmitic acid binding cavity of Na-ASP-2. Additionally, ascr#3, an ascaroside that is present in mammalian hookworm E-S products binds to the palmitic acid binding cavity of Na-ASP-2, whereas oscr#10 which is not found in hookworm E-S products does not bind. Future studies are required to determine the structural basis of ascaroside binding by Na-ASP-2 and to understand the physiological significance of these observations. Copy rights belong to original authors. Visit the link for more info
This episode explores new research which has found how satellites can be used to map the effect that ship emissions have on cloud formation. --- Read this episode's science poem here. Read the scientific study that inspired it here. Read ‘Oh Great O North Cloud' by Allen Grossman here. --- Music by Rufus Beckett. --- Follow Sam on social media and send in any questions or comments for the podcast: Email: sam.illingworth@gmail.com Twitter: @samillingworth
Secreted within the pages of the Bible lie a series of hidden gems that are only visible in the original Hebrew language. Dr. Danny Ben Gigi makes the Scriptures come alive through the language of God, giving us a new and deeper appreciation for God's Word. Many things that aren't visible in our English Bible translations take on new life when viewed through the Hebrew lens. Tune in to see what you've been missing!
Pete messed up and thought it was the 20th episode but he got a little ahead of himself. No biggie! It's our first opportunity to answer a few listener questions from the Facebook group on the podcast. Question 1: When do I eat working nights? I normally do 6 nights in a row and have 8 off . I also do not have a gallbladder , will that be a problem eating high fat ? Q1: Part I - The Gallbladder What does the Gallbladder Do Liver creates bile, gallbladder stores it. Secreted when eating fat If bile is stagnant - stones form Other risk factors too including estrogen Keep the gallbladder working to prevent stones! Eat fat Weight loss leads to gallstones but prevented if weight loss is achieved by high fat diet http://gut.bmj.com/content/54/6/823 http://www.cghjournal.org/article/S1542-3565(13)01837-5/abstract How to eat when you have gallstones? Once you have them, talk to GI about ways to get rid of them without surgery You might have to cut back on fat a tad or eat in smaller amounts Not time for OMAD - might not work for you How to eat when you don’t have a gallbladder? Still can eat fat but if you have digestive issues (nausea) - might need to decrease a tad Eat small meals (no OMAD or IF) Medium chain fatty acids are easier to digest Coconut oil, full fat dairy products, MCT oil Eat small amounts of Long chain fatty acids at a time: omega 6 and omega 3 fatty acids (nuts/fish/veggie oils) NEVER EAT VEGGIE OILS - PERIOD Enzymes supplementation and bile acid supplementation Try to avoid gallbladder surgery Only if cholecystitis or choledocolithiasis https://www.dietdoctor.com/gallstones-and-low-carb Q1: Part II - On Night Shift Eating Everyone will be different Two different people People who always work nights Make a commitment for 21 days to whatever your plan is Your body will come to expect or not expect food If you must eat - stay super low carb (keep that insulin low) People who change (ME) I never eat on my night shift Your insulin resistance is up Cortisol is up I eat at dinner with my family and breakfast before heading to bed That means I am NOT doing over 12 hr IF I end up eating twice per day. Breakfast before sleep and dinner before shift Question 2: IF / Keto after thyroidectomy Coumadin analogy Don’t change Follow TSH carefully with weight loss Question 3: What can I have during a fast? Depends on your goal. Autophagy vs weight loss Water, salt, coffee probably okay Bone broth if transitioning or longer fast Stick to something that is mostly fat (heavy cream / oil in coffee) - remember insulin Artificial sweeteners (depends) Will spike insulin in some people Will not help with your sugar addiction Makes me nauseous now (used to chew gum) Disrupts gut microbiome Better than sugar if trying to lose weight but weight loss not as fast as if you don’t include
The Estimados Profesores of TWIP solve the case of the Man With Motile Objects, and reveal the secreted and excreted proteins of Giardia parasites. Hosts: Vincent Racaniello, Dickson Despommier, and Daniel Griffin Become a patron of TWiP. Links for this episode: Excretory and secretory products of Giardia intestinalis (PLoS NTD) Image credit Letters read on TWiP 145 Case Study for TWiP 145 Male 40s, visiting NYC on business. Lives in Thailand, seeks medical attention for diarrhea and abdominal pain. Diarrhea is continuous, even at night. Feels swollen. Stool cultures come back negative. CBC reveals eosinophilia. Clinician orders stool O&P. See something in stool: large elliptical objects, over 100 microns. Send your case diagnosis, questions and comments to twip@microbe.tv Music by Ronald Jenkees
Welcome to The Nutritional Pearls Podcast! Focusing on topics that include digestion, adrenal fatigue, leaky gut, supplementation, electrolytes, stomach acid, and so much more, “The Nutritional Pearls Podcast” features Christine Moore, NTP and is hosted by Jimmy Moore, host of the longest running nutritional podcast on the Internet. Sharing nuggets of wisdom from Christine's training as a Nutritional Therapy Practitioner and Jimmy's years of podcasting and authoring international bestselling health and nutrition books, they will feature a new topic of interest and fascination in the world of nutritional health each Monday. Listen in today as Christine and Jimmy dig deep into blood sugar regulation in Episode 3. Here's what Christine and Jimmy talked about in Episode 3: Normal Blood Sugar Regulation 1. Hormones involved in blood sugar regulation A. Insulin 1. Secreted by the beta cells of the pancreas 2. stores glucose in cells 3. brings glucose to the liver so the liver can convert it to glycogen (glycogenesis) B. Glucagon 1. produced by the alpha cells of the pancreas 2. helps maintain blood sugar levels between meals 3. creates “sugar” by glycogenolysis (breakdown of glycogen into glucose in the liver) and gluconeogenesis C. Cortisol 1. Adrenal hormone secreted by the adrenal cortex 2. released by the adrenal glands when blood sugar gets too low because glucagon is not sufficient 3. mobilizes proteins to be converted to glucose 4. replenishes glycogen storage (glycogenesis) 5. Stimulates the breakdown of triglycerides and the release of fatty acids from adipose tissue (lipolysis) D. Epinephrine 1. Stimulates the liver to create glucose from proteins and some fats 2. Stimulates the liver to convert glycogen back to glucose to be released into the bloodstream 3. Increases heart rate and blood pressure 2. Three main organs in blood sugar regulation A. Pancreas 1. Beta Cells release insulin when there is a need for glucose storage 2. Alpha Cells release glucagon when there is a need to make glucose a. signals the liver to turn glycogen into glucose (glycogenolysis) b. signals the liver to break down proteins into glucose (gluconeogenesis) 3. Delta Cells secrete the hormone somatostatin which inhibits gastric secretion B. Liver 1. Creates ketones from fatty acids 2. Receives signals from the pancreas (insulin or Glucagon) to store or create glucose 3. Creates glucose from proteins and some fats C. Adrenal Glands 1. Releases cortisol which mobilizes proteins to help glucose (gluconeogenesis); kicks in when glucagon is not enough 2. Releases epinephrine which helps in emergency situations by increasing heart rate, blood flow to the heart, muscles, and liver, dilates airways and determines our response to stress Nutritional Pearl in Episode 3: It's important to keep blood sugar levels in normal ranges so the adrenal glands don't get worn out INSURANCE JUST FOR KETONIANS NOTICE OF DISCLOSURE: Paid sponsorship COUPON CODE LLVLC FOR 10% OFF YOUR FIRST ORDER NOTICE OF DISCLOSURE: Paid sponsorship GET A $39 BOTTLE OF OLIVE OIL FOR JUST A BUCK GET YOUR $39 BOTTLE FOR JUST $1 NOTICE OF DISCLOSURE: Paid sponsorship BECOME A NUTRITIONAL THERAPY PRACTITIONER Sign up for the 9-month program NOTICE OF DISCLOSURE: Paid sponsorship JIMMY'S KETO LIVING SUPPLEMENT LINE LINKS MENTIONED IN EPISODE 3 – SUPPORT OUR SPONSOR: Complete nutriton for nutritional ketosis (COUPON CODE LLVLC FOR 10% OFF YOUR FIRST ORDER) – SUPPORT OUR SPONSOR: Life Insurance For Your Keto Lifestyle (Use promo code LOW-CARB) – SUPPORT OUR SPONSOR: Become A Nutritional Therapy Practitioner – SUPPORT OUR SPONSOR: The world's freshest and most flavorful artisanal olive oils. Get your $39 bottle for just $1 – JIMMY'S KETO LIVING SUPPLEMENT LINE: Try the KetoEssentials Multivitamin and Berberine Plus ketogenic-enhancing supplements
The TWiPtomaniacs solve the case of the Boy With Visual Disturbances and Itching, and discuss identifying secreted and excreted proteins of Trichinella parasites. Hosts: Vincent Racaniello, Dickson Despommier, and Daniel Griffin Become a patron of TWiP. Links for this episode: Malaria plasmepsins involved in invasion and egress (Science) Image credit Letters read on TWiP 144 Case Study for TWiP 144 Individual in 30s, male, presented to physician with stomach upset, uncomfortable feeling in legs. Has motile objects in stools. From Vancouver BC, was eating salmon, reports was either dried/smoked or marinated. Not sure if this is relevant. Brought motile objects to physician. Send your case diagnosis, questions and comments to twip@microbe.tv Music by Ronald Jenkees
"You win again, gravity!" With Special Guest Theresa Gromek ________________________________________ FOLLOW SLURMCAST ONLINE! www.facebook.com/slurmcast Twitter:@slurmcastpod instagram: @slurmcastpod Call or Text us 1-216-438-1077 (message and data rates may apply) http://www.slurmcast.com slurmcastpod@gmail.com produced and edited by HateCat Inc ©2017 HateCat Inc
Commentary by Dr. Valentin Fuster
This year, we remembered to do a chunder thing, because we are professional pod people. Andelect kicks things off with Valkyria Chronicles, and reveals his racism by mixing up Germans and Russians. Takuna follows this lead with a racially-themed story from Dungeons & Dragons, because he is such a dork like that. Then we talked about other stuff probably, including some game called Jim Fandango or something. Secreted amongst this like diamonds within a crown, we also managed to mock a certain hashtag so many times (Once) that NinjaOx got swatted, and have a really long, controversial discussion about the depiction of Christians within media. Oh boy doesn't this sound like fu
Vincent, Michael, Elio review innate immune sensing of Listeria secreted bacterial nucleic acids, and how Wolbachia enhances egg production in Drosophila.
Tierärztliche Fakultät - Digitale Hochschulschriften der LMU - Teil 03/07
Die equine rezidivierende Uveitis (ERU) ist die häufigste Augenerkrankung bei Equiden. Die pathogenetischen Mechanismen, die den rezidivierenden immunologisch-inflammatorischen Reaktionen und der Schädigung intraokularer Strukturen zu Grunde liegen, sind weitgehend unerforscht. Ziel dieser Arbeit war es, durch die Kombination von zweidimensionaler Gelelektrophorese und massenspektrometrischen Untersuchungen, die Proteinexpression in den Glaskörpern gesunder und an ERU erkrankter Pferde zu analysieren und durch die Identifizierung differenziell exprimierter Proteine, Hinweise auf Mechanismen zu erhalten, die bei der Pathogenese der ERU von Bedeutung sind. Dabei wurde Material verwendet, das bei der therapeutischen Pars-plana-Vitrektomie chirurgisch entfernt wird, was zu einer Reduktion weiterer Schübe führt. Deutliche Unterschiede zwischen gesunden und uveitischen Augen zeigten sich bereits in einer signifikant erhöhten Proteinkonzentration der Glaskörper uveitischer Pferde (3,67 µg/µl ± 2,28 µg/µl bei ERU im Vergleich zu 0,15 µg/µl ± 0,05 µg/µl bei gesunden). Die nach zweidimensionaler Gelelektrophorese des Glaskörpermaterials erhaltenen Proteinmuster der Glaskörper gesunder Augen waren sehr homogen. Ebenso zeigten die Proteinmuster der uveitischen Glaskörper untereinander nur geringe individuelle Unterschiede. Deutliche Unterschiede in der Proteinexpression waren jedoch beim Vergleich von Glaskörpern gesunder und uveitischer Augen festzustellen. Nach massenspektrometrischer Analyse der zweidimensional aufgetrennten Proteine wurden insgesamt elf differenziell exprimierte Proteine identifiziert. Hiervon waren in den Glaskörpern uveitischer Pferde, im Vergleich zu gesunden, sechs Proteine (Albumin, Gamma-Immunglobulin, Komplement C3, Apolipoprotein-AI, Carboxylesterase D1 und Histone deacetylase complex subunit SAP18) höher und fünf Proteine (Plasma Retinol-bindendes Protein, Prostaglandin-H2 D-isomerase, Dickkopf-related protein 3, Secreted frizzled-related protein 2 und Pigment epithelium-derived factor) niedriger exprimiert. Diese differenziell exprimierten Proteine sind im Zusammenhang mit der Blut-Retina-Schranke, mit Immunantworten und der Modulation des Wnt-Signalweges von Bedeutung. Interessant ist insbesondere eine mögliche Beteiligung des Wnt-Signalweges bei der ERU. Dieser wurde im Zusammenhang mit Uveitiden bisher nicht beschrieben. Die signifikant reduzierte Expression konnte für sFRP-2 und PEDF darüber hinaus direkt im retinalen Gewebe gezeigt werden. Dabei konnte zusätzlich ein Zusammenhang zwischen niedrigem PEDF und auftretender VEGF-Expression in der Netzhaut nachgewiesen werden. Die Proteomanalyse hat sich somit als geeignetes Instrument bei der Identifizierung neuer, möglicherweise bei der Pathogenese der ERU relevanter, Proteine und biologischer Signalwege erwiesen.
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