Podcasts about Sabr

American League Division Series - Games Three, Four, and FiveBefore the American League Championship Series begins this Sunday night in Toronto, let's recap the conclusion of the ALDS. The Blue Jays offense continued to torment the Yankees pitching staff en route to a 3 games to one series victory. Vladimir Guerrero, Jr. was unreal, driving in runs in every single game of the series. Nathan Lukes, who had spent nearly a decade toiling as a minor league journeyman, once again came up huge against the Yankee pen. The top team in the American League appears poised to win their first pennant in over 30 years.Meanwhile the Mariners outlasted the Tigers in an epic fifteen inning game five. The Tigers took them to the brink, and then some. Tarik Skubal, Will Vest, and Kerry Carpenter did all they could to try and advance, but AJ Hinch's squad just couldn't produce enough offense. Apart from a game four implosion, Seattle's arms were dominant against Detroit, but they'll have their work cut out for them facing the firepower of Toronto.New York Yankees (94-68) @ Toronto Blue Jays (94-68)Toronto Radio SN590 - Ben Shulman and Chris LerouxNew York Radio WFAN - Dave Sims and Suzyn WaldmanDetroit Tigers (87-75) @ Seattle Mariners (90-72)Seattle Radio KIRO - Rick Rizzs, Aaron GoldsmithDetroit Radio 97.1 the Ticket - Dan Dickerson, Dan PetryAudio clips from MLB.tvAs always, thank you to Baseball Reference and SABR for statistics, box scores, background information, and much, much more.Catch you next time,P.C.O.

The 2025 Phillies are still alive thanks to their 8-2 win over the Dodgers in Game 3 of the NLDS, keeping their season going for at least one more game. On this edition of Hittin' Season, the Good Phight's John Stolnis, Justin Klugh from Baseball Prospectus and Liz Roscher from SABR's Baseball Research Journal recap Game 3, featuring Kyle Schwarber's two homers, phenomenal pitching by Aaron Nola and Ranger Suarez, and a breakout night from the rest of the bats. Plus, the gang sets up Thursday night's Game 4 in L.A. as well.

NLDS Recap Games 1 and 2Chicago Cubs (92-70) @ Milwaukee Brewers (97-65)GM 1: Freddy Peralta (17-6 2.70 ERA 176 IP) vs. Matthew Boyd (14-8 3.21 ERA 179 IP)GM 2: (Aaron Ashby 5-2 2.16 ERA 66 IP) vs. Shota Imanaga (9-8 3.73 ERA 144 IP)Milwaukee Radio WTMJ - Jeff Levering, Bill Schroeder, and Josh MaurerChicago Radio WSCR - Pat Hughes and Ron CoomerThe National League Division Series is under way, and after just two games, the Cubs and Phillies are facing elimination. The Chicago starters could not keep Milwaukee off of the board, with nearly every Brewer finding a way to contribute. As the series heads south to Chicago, Craig Counsell's squad is in deep trouble.Los Angeles Dodgers (93-69) @ Philadelphia Phillies (96-66)GM 1: Christopher Sánchez (13-5 2.50 ERA 202 IP) vs. Shohei Ohtani (1-1 2.87 ERA 47 IP)GM 2: Jesús Luzardo (15-7 3.92 ERA 183 IP) vs. Blake Snell (5-4 2.35 ERA 61 IP)Philadelphia Radio WIP - Scott Franzke, Larry Andersen, and Kevin StockerLos Angeles Radio AM570 - Stephen Nelson and Rick MondayThe Phillies starters, Christopher Sanchez and Jesus Luzardo, performed admirably against the Dodgers, but the bullpen and the bats have not followed suit. For Los Angeles, Shohei Ohtani provided a quality start in his postseason pitching debut, while Blake Snell continued his playoff dominance. Once again, the ‘Brothers Hernández' came up clutch in game one, and the bullpen held on by the skin of their teeth to secure a 2-0 series lead.Audio clips from MLB.tvAs always, thank you to Baseball Reference and SABR for statistics, box scores, background information, and much, much more.Catch you next time,P.C.O.

ALDS Recap - Games One and TwoThe American League Division Series games have started, and boy, have there been some fireworks so far. The Toronto Blue Jays have jumped all over their division rival New York Yankees, with Vladimir Guerrero, Jr., Alejandro Kirk, and Dalton Varsho leading the way. The Yankees will have their work cut out for them if they hope to survive this series.In Seattle, the series is knotted up at a game a piece. Both games were tense and exhilarating. As the series heads to Detroit, we shall see if the stars - Julio Rodrigues, Cal Raleigh, Tarik Skubal, and Kerry Carpenter - can continue to shineAudio clips from MLB.tvNew York Yankees (94-68) @ Toronto Blue Jays (94-68)GM 1 - Kevin Gausman (10-11 3.59 ERA 193 IP) vs. Luis Gil (4-1 3.32 ERA 57 IP)GM 2 - Trey Yesavage (1-0 3.21 ERA 14 IP) vs. Max Fried (19-5 2.86 ERA 195 IP)Toronto Radio SN590 - Ben Shulman and Chris LerouxNew York Radio WFAN - Dave Sims and Suzyn WaldmanDetroit Tigers (87-75) @ Seattle Mariners (90-72)GM 1 - George Kirby (10-8 4.21 ERA 126 IP) vs. Toy M

El video explora el miedo al rechazo y cómo este nos lleva a ocultar nuestro ser autentico. Para evitar el rechazo, muchas personas se colocan una máscara, dejando de lado su identidad propia. Es crucial abrazar la autenticidad y mostrarse tal como uno es. Descarga en tu teléfono la hipnosis que necesitas: http://paconavas.com/tienda Reserva tu cita conmigo desde la web: https://paconavas.com/consulta

National League Wild Card RecapHighlights from the NL side of the Wild Card Round. The Dodgers dominate, as expected, and the Cubs survive a thrilling three game set against the Friars.San Diego Padres (90-72) @ Chicago Cubs (92-70)GM 1: Matthew Boyd (14-8 3.21 ERA 179 IP) vs. Nick Pivetta (13-5 2.87 ERA 181 IP)GM 2: Andrew Kittredge (3-5 3.40 ERA 53 IP) vs. Dylan Cease (8-12 4.55 ERA 168 IP)GM 3: Jameson Taillon (11-7 3.68 ERA 129 IP) vs. Yu Darvish (5-5 5.38 ERA 72 IP)Chicago Radio WSCR - Pat Hughes, Ron CoomerSan Diego Radio KWFN - Jesse Agler and Tony Gwynn, Jr.Cincinatti Reds (83-79) @ Los Angeles Dodgers (93-69)GM 1: Blake Snell (5-4 2.35 ERA 61 IP) vs. Hunter Greene (7-4 2.76 ERA 107 IP)GM 2: Yoshinobu Yamamoto (12-8 2.49 ERA 173 IP) vs. Zach Littell (10-8 3.81 ERA 186 IP)Los Angeles Radio AM570 - Stephen Nelson and Rick MondayCincinatti Radio WLW - Tommy Thrall and Jeff BrantleyAudio clips from MLB.tvAs always, thank you to Baseball Reference and SABR for statistics, box scores, background information, and much, much more.Catch you next time,P.C.O.

American League Wild Card RecapIn the first five years of the Wild Card round(2020, 2022 - Present), we had just 4 of the 20 series go to a third game. This year, we were blessed with three! In today's episode we'll go over the highlights from the American League side, then look ahead to the AL Division Series games that start this weekend. This round had dominant outings from the game's best pitchers, and clutch performances by rising stars. October baseball has it all!Audio clips from MLB.tvDetroit Tigers (87-75) @ Cleveland Guardians (88-74)GM 1: Gavin Williams (12-5 3.06 ERA 167 IP) vs. Tarik Skubal (13-6 2.21 ERA 195 IP)GM 2: Tanner Bibee (12-11 4.24 ERA 182 IP) vs. Casey Mize (14-6 3.87 ERA 149 IP)GM 3: Slade Cecconi (7-7 4.30 ERA 132 IP) vs. Jack Flaherty (8-15 4.64 ERA 161 IP)Cleveland Radio WTAM - Tom Hamilton and Jim RosenhausDetroit Radio 97.1 - Dan Dickerson and Bobby ScalesBoston Red Sox (89-73) @ New York Yankees (94-68)GM 1: Max Fried (19-5 2.86 ERA 195 IP) vs. Garrett Crochet (18-5 2.59 ERA 205 IP)GM 2: Carlos Rodón (18-9 3.09 ERA 195 IP) vs. Brayan Bello (11-9 3.35 ERA 166 IP)GM 3: Cam Schlittler (4-3 2.96 ERA 73 IP) vs. Connelly Early (1-2 2.33 ERA 19 IP)New York Radio WFAN - Dave Sims, and Suzyn WaldmanBoston Radio WEEI - Will Flemming, Will Middlebrooks, Lenny Dinardo, and Lou MerloniAs always, thank you to Baseball Reference and SABR for statistics, box scores, background information, and much, much more.P.C.O.

2025 Regular Season Recap and Wild Card PreviewAnother MLB regular season is in the books, and we are on the verge of playoff baseball once again. Listen in as we discuss the incredible September comebacks of the Reds and Guardians, as well as the dreadful collapses of the Mets and Astros (and nearly the Tigers). I'll provide my thoughts on the MVP races, and finish with a tribute to the endings of some great careers.Audio clips from MLB.tvCleveland Radio WTAM - Tom HamiltonBoston Radio WEEI - Will FlemmingToronto TV Sportsnet - Dan Shulman and Buck MartinezSeattle Radio KIRO - Rick RizzsReds Radio WLW - Tommy Thrall and Jeff BrantleyMets Radio WHSQ - Howie RoseLos Angeles Radio AM570 - Charley Steiner and Rick MondayNationals TV MASN - Bob Carpenter and Kevin FrandsenAs always, thank you to Baseball Reference and SABR for statistics, box scores, background information, and much, much more.Catch you next time,P.C.O.Be on the lookout for a Wild Card series recap and a Division Series preview later this week!

Cómo un CEO influencia .Cómo potenciar tu marca como CEO

Amo ti lasciamo qui sotto il link per scoprire meglio il mondo di Serenis e le possibilità che offre: Codice: POV17 https://www.serenis.it/influencer/pov?utm_source=influencer&utm_medium=affiliate&utm_campaign=POV17&utm_content=podcast&utm_term=host+read Sabrina congratulazioni per essere arrivata alla fine di settembre con un minimo di equilibrio psichico che ti ha permesso di aprire Spotify per essere qui, oggi, domenica, alle 17, per questo nuovo e stratosferico "AMO, CHAT?", che conclude questo primo mese dall'inizio di un nuovo percorso mentale per tutti (perché per quanto non sia un effettivo nuovo anno, lo sia tu e lo sappiamo noi quanto settembre si imponga come il momento in cui TUTTO INIZIA, tipo noi ad alzare il culo verso tutti i doveri che abbiamo procastinato durante l'estate). Le storie di oggi dici Sabrì? Pazzesche, sagaci e pungenti come una vera fruitrice di POV, ma anche introspettive e astrologiche come una vera matta di paese che abita le corriere cittadine. Ti aspettiamo dopo il play splendore. Email dove inviarci le storie da leggere la domenica: amochatpov@gmail.com

On Episode 1014 of Hittin' Season, John Stolnis of The Good Phight, Justin Klugh from Baseball Prospectus and Liz Roscher of SABR's Baseball Research Journal discuss the Philadelphia Phillies' current position as they head into the final week of the regular season and prepare for the postseason. They analyze key players to watch, including milestones for Trea Turner and Kyle Schwarber, and the importance of maintaining momentum. The conversation shifts to pitching strategies, particularly the roles of Aaron Nola and Walker Buehler in the playoffs. Lineup adjustments are also examined, with a focus on how the team is responding to Alec Bohm's return. The episode concludes with a discussion on the controversy surrounding Nick Castellanos and the competitive landscape of the National League wild card race.

Cómo un CEO influencia .Cómo potenciar tu marca como CEO

# TEMA CREANDO CONCIENCIA ARTIFICIAL... Y nunca lo sabrás+Análisis entrevista a Karl Friston & Mark Solms# PRESENTA Y DIRIGE 

What does it really mean to rely on Allah in your darkest moments?In this heartfelt and spiritually grounded episode, Razia Hamidi joins Boonaa Mohammed to explore the essence of Dua and Sabr in a believer's life. Razia reflects on her upbringing as a child of Afghan refugees, her family's journey of resilience, and how those foundations shaped her deep reliance on Allah.She shares:

Ted Knorr has been a member of SABR since 1979, has attended over 60 SABR conferences, and started Negro League Commemorative Nights in Harrisburg, Lancaster, and York, Pennsylvania. In 1997 he founded SABR's Negro League Conference, now called the Jerry Malloy Negro League Conference. A lifelong trivia fan he chased the SABR Conferences team trivia title starting in 1984 and finally won the title in 2022. He also won the Jerry Malloy Negro League Conference title in 2009, the only person in SABR to have won both! Ted recently attended this year's Jerry Malloy Conference, his 25th such conference.Ted discuss the HOF case for Rap Dixon, who started his career with the Harrisburg Giants in 1924 and played for 12 years, retiring with a career .336 batting average and .969 OPS. His best season was 1928 with the Baltimore Black Sox when he led the league in WAR, Games played, hits, triples, home runs, RBI, stolen bases, walks, slugging, OPS, OPS+ and total bases. Rap is one of many players from the Negro Leagues who deserve a plaque in Cooperstown! 

For the fourth year in a row, the Phillies are going to the playoffs. They had a chance to clinch the NL East on Sunday but came up short, so they'll look to do it this week in Los Angeles. On Episode 1012 of Hittin' Season, John Stolnis of The Good Phight, Baseball Prospctus' Justin Klugh and Liz Roscher, editor of SABR's Baseball Research Journal discuss the weekend series against the Royals and a remarkable week of baseball that has them humming and ready for October!

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After the Phillies' 1-0 win over the Mets in Philadelphia on Monday night, is the National League East race now over? On Episode 1009 of Hittin' Season, John Stolnis of The Good Phight, Baseball Prospectus' Justin Klugh and Liz Roscher, Editor of SABR's Baseball Research Journal, discuss Aaron Nola's performance and the Phils' 8-game lead in the division with three more to play. Also, a discussion about Trea Turner's hamstring injury, Alec Bohm hitting the Injured List, and a conversation about America's newest villain, Philly Karen.

Dr. Beckett discusses his early collecting experiences, the culture and trends of card collecting from the 1950s through the 1960s, and key moments that shaped the hobby. Interviewed by Mark Armour and Jason Schwartz from SABR, Dr. Beckett shares personal anecdotes, the impact of moving frequently as a child, and how collecting methods varied across different neighborhoods and eras. He highlights iconic cards and sets, including the significance of the 1957 Topps set, the emergence of the Stan Musial All-Star card in 1958, and his cherished Christmas gift in 1959 that deepened his apssion for collecting.    01:31 Childhood Memories and Collecting Stories 03:21 Trading and Collecting Practices 05:08 Card Series and Releases 09:29 Evolution of Card Collecting 17:54 Christmas of 1959 and Family Influence  

Dr. Pedro Barata and Dr. Rana McKay discuss the integration of innovative advances in molecular imaging and therapeutics to personalize treatment for patients with renal cell and urothelial carcinomas. TRANSCRIPT Dr. Pedro Barata: Hello, I'm Dr. Pedro Barata, your guest host of By the Book, a podcast series featuring insightful conversations between authors and editors of the ASCO Educational Book. I'm a medical oncologist at University Hospitals Seidman Cancer Center and an associate professor of medicine at Case Western Reserve University in Cleveland, Ohio. I'm also an associate editor of the ASCO Educational Book. Now, we all know the field of genitourinary cancers (GU) is evolving quite rapidly, and we have new innovations in molecular imaging as well as targeted therapeutics. Today's episode will be exploring novel approaches that are transforming the management of renal cell and urothelial carcinomas and also their potential to offer a more personalized treatment to patients. For that, joining for today's discussion is Dr. Rana McKay, a GU medical oncologist and professor at University of California San Diego. Dr. McKay will discuss her recently published article titled, “Emerging Paradigms in Genitourinary Cancers: Integrating Molecular Imaging, Hypoxia-Inducible Factor-Targeted Therapies, and Antibody-Drug Conjugates in Renal Cell and Urothelial Carcinomas.”  Our full disclosures are available in the transcript of this episode.  And with that, Rana McKay, great to have you on the podcast today. Dr. Rana McKay: Oh, thank you so much, Dr. Barata. It's really wonderful to be here with you. So, thanks for hosting. Dr. Pedro Barata: No, thanks for taking the time, and I'm looking forward to this conversation. And by the way, let me start by saying congrats on a great article in the Educational Book. Really super helpful paper. I'm recommending it to a lot of the residents and fellows at my own institution. I would like to first ask you to kind of give our listeners some context of how novel approaches in the molecular imaging as well as targeted therapeutics are actually changing the way we're managing patients with GU, but specifically with renal cell carcinoma and urothelial carcinoma. So, what are the areas you would call out as like being big areas for innovation in this context, and why are they important? Dr. Rana McKay: Very good question. And I think this is really what this article highlights. It highlights where are we going from an imaging diagnostics standpoint? Where are we going from a therapeutic standpoint? And I think if we have to step back, from the standpoint of diagnostics, we've seen PET imaging really transform diagnostics in prostate cancer with the advent of PSMA PET imaging, and now PSMA PET imaging is used as a biomarker for selection for theranostics therapy. And so, we're starting to see that enter into the RCC landscape, enter into the urothelial cancer landscape to a lesser extent. And I think it's going to potentially be transformative as these tools get more refined. I think when we think about therapeutics, what's been transformative most recently in the renal cell carcinoma landscape has been the advent of HIF2α inhibition to improve outcomes for patients. And we have seen the approval of belzutifan most recently that has reshaped the landscape. And now there's other HIF2α inhibitors that are being developed that are going to be further important as they get refined. And lastly, I think when we think about urothelial carcinoma, the greatest transformation to treatment in that context has been the displacement of cisplatin and platinum-based chemotherapy as a frontline standard with the combination of enfortumab vedotin plus pembrolizumab. And we've seen antibody-drug conjugates really reshape treatment and tremendously improve outcomes for patients. So, I think those are the three key areas of interest. Dr. Pedro Barata: So with that, let's focus first on the imaging and then we'll get to the therapeutic area. So, we know there's been a paradigm shift, really, when prostate-specific targets emerged as tracers for PET scanning. And so, we now commonly use prostate-specific membrane antigen, or PSMA-based PET scanning, and really transform how we manage prostate cancer. Now, it appears that we're kind of seeing a similar wave in renal cell carcinoma with the new radiotracer against the target carbonic anhydrase IX. What can you tell us about this? And is this going to be available to us anytime soon? And how do you think that might potentially change the way we're managing patients with RCC today? Dr. Rana McKay: First, I'll step back and say that in the context of PSMA PET imaging, we have actually been able to better understand RCC as well. So, we know that PSMA is expressed in the neovasculature of tumors, and it can actually be used to detect renal cell carcinoma tumors. It has a detection rate of about 84% when used for detection. And so, you know, I don't think it's just restricted to carbonic anhydrase IX, but we will talk about that. So, PSMA expressed in the neovasculature has a detection rate of around 84%, particularly if we're looking at clear cell RCC. CAlX is overexpressed in clear cell RCC, and it's actually used in diagnosing renal cell carcinoma when we think of CAlX IHC for diagnosing clear cell RCC. And now there are CAlX PET tracers. The first foray was with the ZIRCON study that was actually an interestingly designed study because it was designed to detect the likelihood of PET imaging to identify clear cell RCC. So, it was actually used in the early diagnostics setting when somebody presents with a renal mass to discriminate that renal mass from a clear cell versus a non-clear cell, and it was a positive study. But when I think about the potential application for these agents, you know, I think about the entire landscape of renal cell carcinoma. This is a disease that we do treat with metastasis-directed therapy. We have certainly seen patients who've undergone metastasectomy have long, durable remissions from such an approach. And I think if we can detect very early onset oligometastatic disease where a metastasis-directed therapy or SABR could be introduced - obviously tested in a trial to demonstrate its efficacy - I think it could potentially be transformative. Dr. Pedro Barata: Wonderful. It's a great summary, and I should highlight you are involved in some of those ongoing studies testing the performance of this specific PET scanning for RCC against conventional imaging, right? And to remind the listeners, thus far, for the most part, we don't really do FDG-PET for RCC. There are some specific cases we do, but in general, they're not a standard scanning. But maybe that will change in the future. Maybe RCC will have their own PSMA-PET. And to your point, there's also emerging data about the role of PSMA-PET scanning in RCC as well, as you very elegantly summarized. Wonderful. So, let me shift gears a little bit because you did, in your introduction, you did highlight a novel MOA that we have in renal cell carcinoma, approved for use, initially for VHL disease, and after that for sporadic clear cell renal cell carcinoma. We're talking about hypoxia-inducible factor 2-alpha inhibitors, or HIF2α inhibitors, such as belzutifan. But there's also others coming up. So, as a way to kind of summarize that, what can you tell us about this breakthrough in terms of therapeutic class, this MOA that got to our toolbox of options for patients with advanced RCC? Tell us a little bit what is being utilized currently in the management of advanced RCC. And where do you see the future going, as far as, is it moving early on? Is it getting monotherapy versus combinations? Maybe other therapies? What are your thoughts about that? What can you tell us about it? Dr. Rana McKay: Belzutifan is a first-in-class HIF2α inhibitor that really established clinical validation for HIF2α as a therapeutic target. When we think about the activity of this agent, the pivotal LITESPARK-005 trial really led to the approval of belzutifan in patients who were really heavily pretreated. It was patients who had received prior IO therapy, patients who had received prior VEGF-targeted therapy. And in the context of this study, we saw a median PFS of 5.6 months, and there did seem to be a tail on the curve when you looked at the 12-month PFS rate with belzutifan. It was 33.7% compared to 17.6% with everolimus. And then when we look at the response rate, it was higher with belzutifan on the order of 22-23%, and very low with everolimus, as we've previously seen. I think one of the Achilles heels of this regimen is the primary PD rate, which was 34% when used in later line. There are multiple studies that are testing belzutifan in combination across the treatment landscape. So, we have LITESPARK-011, which is looking at the combination of belzutifan plus lenvatinib in the second-line setting. We've got the MK-012 [LITESPARK-012] study, which is looking at belzutifan in various combinations in the frontline setting. So there is a combination with IO plus belzutifan. And so this is also being looked at in that context. And then we also have the LITESPARK-022 study, which is looking at pembrolizumab with belzutifan in the adjuvant setting. So there's a series of studies that will be exploring belzutifan really across the treatment landscape. Many of these studies in combination. Additionally, there are other HIF2α inhibitors that are being developed. We have casdatifan, which is another very potent HIF2α inhibitor. You know, I think pharmacologically, these are different agents. There's a different half-life, different dosing. What is going to be the recommended phase 3 dose for both agents, the EPO suppression levels, the degree of EPO suppression, and sustainability of EPO suppression is very different. So, I think we've seen data from casdatifan from the ARC-20 trial from monotherapy with a respectable response rate, over 30%, primary PD rate hovering just around 10%.  And then we've also seen data of the combination of casdatifan with cabozantinib as well that were recently presented this year. And that agent is also being tested across the spectrum of RCC. It's being looked at in combination with cabozantinib in the PEAK-1 study, and actually just at the KCRS (Kidney Cancer Research Summit), we saw the unveiling of the eVOLVE-RCC trial, which is going to be looking at a volrustomig, which is a PD-1/CTLA-4 inhibitor plus casdatifan compared to nivo-ipi in the frontline setting.  So, we're going to see some competition in this space of the HIF2α inhibitors. I think when we think of mechanism of action in that these are very potent, not a lot of off-target activity, and they target a driver mutation in the disease. And that driver mutation happens very early in the pathogenesis. These are going to be positioned much earlier in the treatment landscape. Dr. Pedro Barata: All these studies, as you're saying, look really promising. And when we talk about them, you mentioned a lot of combinations. And to me, when I think of these agents, it makes a lot of sense to combine because there's not a lot of overlapping toxicities, if you will. But perhaps for some of our listeners, who have not used HIF2α inhibitors in practice yet, and they might be thinking about that, what can you tell us about the safety profile? How do you present it to your patients, and how do you handle things like hypoxia or anemia? How do you walk through the safety profile and tolerability profile of those agents like belzutifan? Dr. Rana McKay: I think these drugs are very different than your traditional TKIs, and they don't cause the classic symptoms that are associated with traditional TKIs that many of us are very familiar with like the rash, hand-foot syndrome, hypertension, diarrhea. And honestly, these are very nuanced symptoms that patients really struggle with the chronicity of being on a chronic daily TKI. The three key side effects that I warn patients about with HIF2α inhibitors are: (1) fatigue; (2) anemia; and (3) hypoxia and dysregulation in the ability to sense oxygen levels. And so, many of these side effects - actually, all of them - are very dose-dependent. They can be very well-managed. So, we can start off with the anemia. I think it's critically important before you even start somebody on belzutifan that you are optimizing their hemoglobin and bone marrow function. Make sure they don't have an underlying iron deficiency anemia. Make sure they don't have B12 or folate deficiency. Check for these parameters. Many patients who have kidney cancer may have some hematuria, other things where there could be some low-level blood loss. So, make sure that those are resolved or you're at least addressing them and supplementing people appropriately. I monitor anemia very closely every 3 to 4 weeks, at least, when people start on these medications. And I do initiate EPO, erythropoietin, should the anemia start to worsen. And I typically use a threshold of around 10g/dL  for implementing utilization of an EPO agent, and that's been done very safely in the context of the early studies and phase 3 studies as well. Now, with regards to the hypoxia, I think it's also important to make sure that you're selecting the appropriate individual for this treatment. People who have underlying COPD, or even those individuals who have just a very high burden of disease in their lung, lymphangitic spread, pleural effusions, maybe they're already on oxygen - that's not an ideal candidate for belzutifan. Something that very easily can be done in the clinic before you think about initiating somebody on this treatment, and has certainly been integrated into some of the trials, is just a 6-minute walk test. You know, have the patient walk around the clinic with one of the MAs, one of the nurses, put the O2 sat on [measuring oxygen saturation], make sure they're doing okay. But these side effects, like I said, are very dose-dependent. Typically, if a patient requires, if the symptoms are severe, the therapy can be discontinued and dose reduced. The standing dose is 120 mg daily, and there's two dose reductions to 80 mg and 40 mg should somebody warrant that dose modification. Dr. Pedro Barata: This is relatively new, right? Like, it was not that we're used to checking oxygen levels, right? In general, we're treating these patients, so I certainly think there's a learning curve there, and some of the points that you highlight are truly critical. And I do share many of those as well in our practice. Since I have you, I want to make sure we touch base on antibody-drug conjugates as well. It's also been a hot area, a lot of developments there. When I think of urothelial carcinoma and renal cell carcinoma, I see it a little bit different. I think perhaps in urothelial carcinoma, antibody-drug conjugates, or ADCs, are somewhat established already. You already mentioned enfortumab vedotin. I might ask you to expand a little bit on that. And then in renal cell carcinoma, we have some ADCs as well that you include in your chapter, and that I would like you to tell us what's coming from that perspective. So, tell us a little bit about how do you see ADCs in general for GU tumors, particularly UC and RCC? Tell us a little bit about the complexity or perhaps the challenges you still see. At the same time, tell us about the successes. Dr. Rana McKay: Stepping back, let's just talk about like the principles and design of ADCs. So, most ADCs have three components. There's a monoclonal antibody that typically targets a cell surface antigen, which is conjugated by a linker, which is the second component, to a payload drug. And typically, that payload drug has been chemotherapy, whether it be topoisomerase or whether it be MMAE or other chemotherapeutic. We can start in the RCC space. There's been multiple antibody-drug conjugates that have been tested. There's antibody-drug conjugates to CD70, which is expressed on clear cell RCC. There's been antibody-drug conjugates to ENPP3, which is also expressed on RCC. There's antibody-drug conjugates to CDH6. And they have different payloads, like I said, whether it be topoisomerase I or other microtubule inhibitors. Now, when we think about kidney cancer, we don't treat this disease with chemotherapy. This disease is treated with immunotherapy. It is treated with treatments that target the VEGF pathway and historically has not been sensitive to chemo. So, I think even though the targets have been very exciting, we've seen very underwhelming data regarding activity, and in some context, seen increased toxicity with the ADCs. So, I think we need to tread lightly in the context of the integration and the testing of ADCs in RCC. We just came back from the KCRS meeting, and there was some very intriguing data about a c-Kit ADC that's being developed for chromophobe RCC, which is, you know, a huge unmet need, these variant tumors that really lack appropriate therapeutics. But I just caution us to tread lightly around how can we optimize the payload to make sure that the tumor that we're treating is actually sensitive to the agent that's targeting the cell kill. So, that's a little bit on the ADCs in RCC. I still think we have a long way to go and still in early testing. Now, ADCs for UC are now the standard of care. I think the prototypical agent, enfortumab vedotin, is a nectin-4-directed ADC that's conjugated to an MMAE payload and was the first ADC approved for advanced urothelial, received accelerated approval following the EV-201 trial, which was basically a multicenter, single-arm study that was investigating EV in cisplatin-ineligible patients with advanced urothelial carcinoma, and then ultimately confirmed in the EV-301 study as well. And so, that study ended up demonstrating the support superiority of EV from an overall survival standpoint, even PFS standpoint. Building on that backbone is the EV-302 study, which tested EV in combination with pembrolizumab versus platinum-based chemotherapy in the frontline setting. And that was a pivotal, landmark study that, like I said, has displaced platinum therapy as a frontline treatment for people with advanced urothelial carcinoma. And when we think about that study and the median overall survival and just how far we've come in urothelial cancer, the median OS with EV-pembro from that trial was 31 and a half months. I mean, that's just incredible. The control arm survival was 16 and a half months. The hazard ratio for OS, 0.47. I mean this is why when this data was presented, it was literally a standing ovation that lasted for several minutes because we just haven't seen data that have looked that good. And there are other antibody-drug conjugates that are being tested. We've all been involved in the saga with sacituzumab govitecan, which is a trophoblast cell surface antigen 2 (Trop-2) targeted ADC with a topoisomerase I payload. It was the second ADC to receive approval, but then that approval was subsequently withdrawn when the confirmatory phase 3 was negative, the TROPiCS-04 trial. So, approval was granted based off of the TROPHY-U-01, single-arm, phase 2 study, demonstrating a response rate of around 28% and a PFS of, you know, about 5 and a half months. But then failure to show any benefit from an OS standpoint. And I think there's a lot of controversy in the field around whether this agent still has a role in advanced urothelial carcinoma. And I think particularly for individuals who do not have molecular targets, like they're not HER2-amplified or have HER2-positivity or FGFR or other things like that. Dr. Pedro Barata: Fantastic summary, Rana. You were talking about the EV, and it came to mind that it might not be over, right, for the number of ADCs we use in clinical practice in the near future. I mean, we've seen very promising data for ADC against the HER2, right, and over-expression. It also can create some challenges, right, in the clinics because we're asking to test for HER2 expression. It's almost like, it's not exactly the same to do it in breast cancer, but it looks one more time that we're a little bit behind the breast cancer field in a lot of angles. And also has vedotin as a payload. Of course, I'm referring to disitamab vedotin, and there's very elegant data described by you in your review chapter as well. And it's going to be very interesting to see how we sequence the different ADCs, to your point as well. So, before we wrap it up, I just want to give you the opportunity to tell us if there's any area that we have not touched, any take-home points you'd like to bring up for our listeners before we call it a day. Dr. Rana McKay: Thank you so much. I have to say, you know, I was so excited at ASCO this year looking at the GU program. It was fantastic to see the progress being made, novel therapeutics that really there's a tremendous excitement about, not just in RCC and in UC, but also in prostate cancer, thinking about the integration of therapies, not just for people with refractory disease that, even though our goal is to improve survival, our likelihood of cure is low, but also thinking about how do we integrate these therapies early in the treatment landscape to enhance cure rates for patients, which is just really spectacular. We're seeing many of these agents move into the perioperative setting or in combination with radiation for localized disease. And then the special symposium on biomarkers, I mean, we've really come a long, long way. And I think that we're going to continue to evolve over the next several years. I'm super excited about where the field is going in the treatment of genitourinary malignancies. Dr. Pedro Barata: Oh, absolutely true. And I would say within the Annual Meeting, we have outstanding Educational Sessions. And just a reminder to the listeners that actually that's where the different teams or topics for the Educational Book chapters come from, from actually the educational sessions from ASCO. And your fantastic chapter is an example of that, right, focusing on advanced GU tumors. So, thank you so much, Rana, for taking the time, sharing your insights with us today on the podcast. It was a fantastic conversation as always. Dr. Rana McKay: My pleasure. Thanks so much for having me, Dr. Barata. Dr. Pedro Barata: Of course.  And thank you to our listeners for your time today. You will find the link to the article discussed today in the transcript of this episode. I also encourage you to check out the 2025 ASCO Educational Book. You'll find an incredible wealth of information there. It's free, available online, and you'll find, hopefully, super, super important information on the key science and issues that are shaping modern oncology, as we've heard from Dr. McKay and many other outstanding authors. So, thank you, everyone, and I hope to see you soon. Disclaimer: The purpose of this podcast is to educate and to inform. This is not a substitute for professional medical care and is not intended for use in the diagnosis or treatment of individual conditions. Guests on this podcast express their own opinions, experience, and conclusions. Guest statements on the podcast do not express the opinions of ASCO. The mention of any product, service, organization, activity, or therapy should not be construed as an ASCO endorsement. Follow today's speakers:        Dr. Pedro Barata @PBarataMD Dr. Rana McKay @DrRanaMcKay Follow ASCO on social media:        @ASCO on X (formerly Twitter)        ASCO on Bluesky       ASCO on Facebook        ASCO on LinkedIn        Disclosures:     Dr. Pedro Barata: Stock and Other Ownership Interests: Luminate Medical Honoraria: UroToday Consulting or Advisory Role: Bayer, BMS, Pfizer, EMD Serono, Eisai, Caris Life Sciences, AstraZeneca, Exelixis, AVEO, Merck, Ipson, Astellas Medivation, Novartis, Dendreon Speakers' Bureau: AstraZeneca, Merck, Caris Life Sciences, Bayer, Pfizer/Astellas Research Funding (Inst.): Exelixis, Blue Earth, AVEO, Pfizer, Merck  Dr. Rana McKay: Consulting or Advisory Role: Janssen, Novartis, Tempus, Pfizer, Astellas Medivation, Dendreon, Bayer, Sanofi, Vividion, Calithera, Caris Life Sciences, Sorrento Therapeutics, AVEO, Seattle Genetics, Telix, Eli Lilly, Blue Earth Diagnostics, Ambrx, Sumitomo Pharma Oncology, Esiai, NeoMorph, Arcus Biosciences, Daiichi Sankyo, Exelixis, Bristol Myers Squibb, Merck, Astrazeneca, Myovant Research Funding (Inst.): Bayer, Tempus, AstraZeneca, Exelixis, Bristol Myers Squibb, Oncternal Therapeutics, Artera    

Against the team with the best record in baseball, the Phillies won two out of three this week and are in prime position for the No. 2 seed in the National League. On the latest Hittin' Season, John Stolnis of The Good Phight and Liz Roscher, editor of SABR's Baseball Research Journal, recap a fun series in Milwaukee, discuss Aaron Nola's future, Harrison Bader's surge, the outfield platoon and preview this upcoming weekend in the National League. Chapters: 00:00 - Injury Updates and Series Overview 03:03 - Phillies vs. Brewers: A Playoff Preview? 06:05 - Key Performances and Clutch Moments 08:53 - Outfield Dynamics and Player Changes 11:56 - Ranger Suarez: The Emerging No. 2 14:45 - Aaron Nola's Performance and Future Outlook 30:33 - Phillies' Pitching Dilemmas and Playoff Considerations 35:37 - Kyle Schwarber's Slump and Offensive Impact 39:01 - Upcoming Series vs. Marlins and NL Weekend Slate

"Feel and timing” is a mysterious concept for many riders because no one ever explains what it actually is, or how to grow it. In this episode, Jake breaks it down into what he calls the "four-factor awareness model" — Softness, Acceptance, Balance, Rhythm (SABR). These four layers act like tumblers on a combination lock: at first you just reward basic physical compliance, then mental relaxation, then true balance, and finally rhythm as the capstone. SABR gives you a roadmap, both for teaching any maneuver and refining your own feel in the saddle. If you've ever wondered how expert trainers seem to “just know,” this episode decodes the structure behind that awareness.

On Labor Day, the Phillies won a thriller over the Brewers for what was easily their best win of the season. On Episode 1007 of Hittin' Season, John Stolnis of The Good Phight, Liz Roscher, Editor of SABR's Baseball Research Journal, and Justin Klugh of Baseball Prospectus discuss Monday's dramatic win, the impact of players like Garrett Stubbs and Harrison Bader, and the performance of the bullpen. As September approaches, the hosts make predictions about the team's chances in the playoffs and the potential for Kyle Schwarber to break Ryan Howard's home run record. Chapters: 00:00 - Phillies' Dramatic Win Over the Brewers 02:59 - Justin Klugh's Upcoming Book on the 1941 Phillies 05:49 - Resilience in the Face of Adversity 09:04 - Key Players Making a Difference 11:53 - The Impact of Garrett Stubbs' Return 14:53 - Harrison Bader's Contributions to the Team 18:02 - Future Considerations for the Phillies 20:55 - Did Realmuto Swing? 26:08 - Managing Player Dynamics: Rob Thompson's Approach 34:38 - Analyzing the Brewers: Strengths and Weaknesses 39:38 - Phillies' Resilience: Learning from Past Series 42:11 - Bullpen Concerns: Navigating Late-Season Challenges 52:38 - September Predictions: Home Run Records and Team Performance 54:22 - Home Run Records and Player Performance 56:20 - Pitching Prospects: Ranger Suarez vs. Jesus Luzardo 59:20 - Aaron Nola's Final Month and Team Dynamics 01:01:11 - Phillies' Division Chances and Playoff Prospects 01:07:15 - Final Thoughts and Reflections on the Season

Apologies for an extra re-run this month. Mike is dealing with a personal thing, and we will be back with a new episode next week. Some people podcast about history. Some people witness it. Melissa Ludtke made it happen, successfully fighting back against Bowie Kuhn and Major League Baseball to ensure women in journalism could be on equal footing with male sportswriters. Mike, Bill and Mike Duncan (@MikeDuncan) talk with her about that experience, about the importance of representation for women in baseball, and about the book she was working on at the time. This book is now finished and is called Locker Room Talk: A Woman's Struggle To Get Inside. It's fantastic.

Dr. Beckett recaps episodes 1401 through 1424, expressing gratitude to loyal listeners for their active participation. The episode covers various topics, such as tributes to sports dignitaries like Dave Parker, discussions on the feasibility of a sports card cruise with AI involvement, and an insightful exchange with Iowa Dave Schwartz. The episode also includes special presentations from the SABR convention, conversations on rookie cards, and reflections on the 2025 Chicago National. Additionally, Dr. Beckett delves into Panini's blockchain initiatives and Upper Deck's unique approach to hockey cards, among other subjects.    00:34 Tributes to Sports Legends 01:14 AI and Sports Card Cruise 01:40 Dueling Questions and SABR Presentation 03:37 National Perspectives and Pre-National Ramblings 06:41 Panini Blockchain and Upper Deck Innovations 08:21 Sports Card History and T206 Set    

Round one goes to the Mets, clobbering the Phillies in Monday's opener of a crucial three-game series between the two clubs vying for first in the National League East. On Episode 1003 of Hittin' Season, John Stolnis of The Good Phight, Justin Klugh from Baseball Prospectus and SABR's Liz Roscher chat about a brutal night at Citi Field, the Phils' own personal House of Horrors over the last three seasons. The offense blew scoring chances early, Cristopher Sanchez couldn't hold a lead, the defense was brutal, and yes, Jordan Romano entered the festivities. What does it mean for the rest of the week? How vital is at least one win from the Mets by Wednesday? Chapters 00:00 - Introduction and Initial Reactions 02:43 - Game Overview and Key Moments 05:42 - Phillies' Performance and Missed Opportunities 08:44 - Historical Struggles at Citi Field 11:30 - Emotional Impact of Rivalry Games 14:41 - Pitching Decisions and Game Management 17:40 - Conclusion and Future Outlook 24:52 - Game Analysis and Player Performance 27:36 - Struggles Against Rival Bullpens 30:09 - Frustrations of Phillies Fans 35:18 - Bryce Harper's Rivalry Pack 43:11 - Karma and Performance Metrics 46:27 - The Impact of Zach Wheeler's Injury 48:45 - Rallying for Wheeler 52:05 - The Depth of the Phillies' Rotation 55:24 - Final Thoughts on the Season

After another late inning win over the Reds Monday night, the Phillies roll continues with contributions up and down the lineup and from the most pleasant surprise of the season - Taijuan Walker. On Episode 997 of Hittin' Season, John Stolnis of The Good Phight and Liz Roscher of SABR's Baseball Research Journal discuss the weekend sweep of the Rangers, the remarkable turnaround of the Jhoan Duran-led bullpen, Zack Wheeler's velocity drop and the freefalling Mets.

On Episode 994 of Hittin' Season, powered by WHYY, John Stolnis of SB Nation's The Good Phight, Justin Klugh from Baseball Prospectus and SABR's Liz Roscher discuss the Phillies' series win over Detroit and their Monday night 13-3 blowout of the Baltimore Orioles, highlighting key players like Kyle Schwarber and Christopher Sanchez. They delve into the MVP candidacy of Schwarber, compare his stats with Shohei Ohtani, and analyze the outfield situation, particularly the struggles of Max Kepler. The conversation also touches on Zack Wheeler's recent performance and injury updates for the Phils. Chapters 00:00 - Introduction and Game Overview 02:46 - Phillies' Performance and Player Highlights 05:27 - Kyle Schwarber's MVP Candidacy 08:37 - Comparing Stats: Schwarber vs. Ohtani 11:34 - Contract Talks and Future Considerations 14:30 - Outfield Dynamics and Player Decisions 21:09 - Max Kepler's Struggles and Stats 23:31 - Outfield Decisions and Roster Moves 25:56 - Power Surge: Phillies' Offense in the Second Half 29:29 - The Importance of Comeback Wins 33:42 - The Jhoan Duran Effect: A New Closer's Impact 39:26 - Christopher Sanchez: Rising Star in the Rotation 47:13 - Concerns About Zach Wheeler 54:28 - Injury Updates and Final Thoughts

En el mundo existen más de 250 razas de gatos: calvos y peludos, gruñones y amistosos, cariñosos e independientes. ¿Cuánto cuesta la raza más cara? ¿Sabrías decirlo? Para ser sinceros, estarás sorprendido al descubrir los precios de los gatos más exóticos del mundo. ¿Sabes cuál es el más caro? Este gato es muy costoso pero increíblemente hermoso. Learn more about your ad choices. Visit megaphone.fm/adchoices

Bo Carter is the Executive Director for the National Collegiate Baseball Writers Association and an inductee into the College Sports Communicators Hall of Fame. He was media relations director for the Southwest Conference (SWC) and Big 12 Conference for a combined 22 years. His essay, "Southwest Conference Baseball HIstory," was appears in The National Pastime: Baseball in Texas and Beyond (Society of American Baseball Research (SABR), 2005). Carter has been a SABR member since 1993. Bo Carter on SABR - https://sabr.org/authors/bo-carter/"Southwest Conference Baseball History" - https://sabr.org/journal/article/southwest-conference-baseball-history/National Collegiate Baseball Writers Association - https://www.sportswriters.net/ncbwa/Errata: On further review, Southwestern's Curt Walker was not the first former SWC player to reach the majors, though he was the first to enjoy a substantial MLB career. Maybe that's for another episode? Hooks & Runs - https://hooksandruns.buzzsprout.comEmail: hooksandruns@protonmail.comCraig on Bluesky (@craigest.bsky.social)Rex (Krazy Karl's Music Emporium) on Facebookhttps://www.facebook.com/people/Krazy-Karlz-Music-Emporium/100063801500293/Hosts Emeriti:Andrew Eckhoff on TikTokhttps://www.tiktok.com/@hofffestEric on Facebookhttps://www.facebook.com/ichaboderic/Music: "Warrior of Light" by ikolics (via Premium Beat)   www.premiumbeat.com/artist/ikoliksThis podcast and this episode are copyright Craig Estlinbaum, 2025.   

En este episodio de expresiones queremos hablar de cinco expresiones que contienen la palabra “codo”. Sabrás por qué es positivo “hincar los codos” y por qué suele ser negativo “empinar el codo”. Muchas gracias por escucharnos, si quieres acceder a ventajas y apoyar este podcast hazte suscriptor premium en: www.hoyhablamos.com Editar extracto

On Episode 991 of Hittin' Season, powered by WHYY, the Good Phight's John Stolnis, Justin Klugh of Baseball Prospectus and editor of SABR's Baseball Research Journal Liz Roscher offer their predictions on what Dave Dombrowski will do at the Trade Deadline this Thursday. Relievers? Bats? Both? Neither? Also, Bryce Harper goes nose-to-nose with Rob Manfred in a heated clubhouse meeting over a potential salary cap, and we recap a mostly good series in the Bronx and a bad start to their series in Chicago Monday night. Takeaways The Phillies are struggling to maintain consistent performance, especially against weaker teams. JT Real Muto's resurgence has significantly improved the Phillies' lineup. The trade deadline is approaching, and the Phillies need to prioritize bullpen help. Bryce Harper's vocal stance against a salary cap highlights player concerns about management's intentions. The dynamics between players and management are tense, especially with Rob Manfred's recent actions. The potential trade market is thinning, making it harder for the Phillies to acquire top talent. Players are increasingly aware of the economic challenges facing baseball and are willing to fight for their rights. The role of former players in management can complicate relationships with current players. The Phillies' management must balance short-term needs with long-term player development. The upcoming trade deadline could significantly impact the team's playoff chances. Chapters 00:00 - Introduction and Overview of the Phillies' Current Situation 04:47 - Trade Deadline Insights and Player Performance 09:49 - The Impact of Key Players on the Phillies' Lineup 14:53 - Analyzing the Phillies' Trade Needs and Strategies 19:47 - Recent Trade Rumors and Market Dynamics 24:48 - Injury Updates and Their Implications for Trades 29:30 - Final Thoughts on the Trade Deadline and Team Prospects 36:17 - Bryce Harper vs. Rob Manfred: Tensions Rise 42:29 - The Impact of Former Players on Current Negotiations Keywords Phillies, trade deadline, Rob Manfred, Bryce Harper, JT Real Muto, MLB, baseball, player performance, labor issues, team dynamics

Episode 301 features Donna Muscarella, President of the Elysian Fields SABR Chapter and Steven Chase, founder of Steve's Original Sauces      Donna Muscarella is a baseball enthusiast, photographer, and mixed-media artist.  Hinchliffe Stadium, one of the few Negro Leagues ballparks still standing, is a repeat subject of Donna's creative compositions.  In 2021, she released her debut trading card set, which used her photography of the historic ballpark on the card fronts.  The card backs featured information about Hinchliffe's Negro Leagues ties.  Donna's Hinchliffe photography appeared on Forbes.com, in the third edition of Turnstyle:  The SABR Journal of Baseball Arts, and her card set was featured on the SABR Baseball Cards Blog.  She has covered events at Hinchliffe Stadium for the National Baseball Hall of Fame and the Charles J. Muth Museum of Hinchliffe Stadium.  Donna serves as president of the Elysian Fields (Northern New Jersey) Chapter of the Society for American Baseball Research (SABR).  Go to  https://linktr.ee/TheLensOfDonnaM  to see more of Donna's artwork.    Stephen Chase is the chef and founder of Steve's Original Sauces, otherwise known as SOS.  Stated on their website, "At Steve's Original Sauces, we believe that every culinary creation deserves a touch of artistry, a dash of passion, and an infusion of exquisite flavor. Founded in the quaint town of Belmont in 2018 by the visionary Stephen Chase, our journey began with a singular mission: to elevate the everyday dining experience through a curated selection of gourmet sauces and syrups that tantalize the palate and inspire the imagination.  As we continue to grow, we remain steadfast in our dedication to creating products that resonate with the discerning tastes of our clientele."  For more information or to make a purchase go to  https://stevesoriginalsauces.com/    We recommend you go to Baseball BBQ, https://baseballbbq.com for special grilling tools and accessories, Magnechef https://magnechef.com/ for excellent and unique barbecue gloves, Cutting Edge Firewood High Quality Kiln Dried Firewood - Cutting Edge Firewood in Atlanta for high quality firewood and cooking wood, Mantis BBQ, https://mantisbbq.com/ to purchase their outstanding sauces with a portion of the proceeds being donated to the Kidney Project, and for exceptional sauces, Elda's Kitchen https://eldaskitchen.com/   We conclude the show with the song, Baseball Always Brings You Home from the musician, Dave Dresser and the poet, Shel Krakofsky. We truly appreciate our listeners and hope that all of you are staying safe. If you would like to contact the show, we would love to hear from you. Call the show:  (516) 855-8214 Email:  baseballandbbq@gmail.com Twitter:  @baseballandbbq Instagram:  baseballandbarbecue YouTube:  baseball and bbq Website:  https//baseballandbbq.weebly.com Facebook:  baseball and bbq

For so long, we've thought that the 4,000 hit club was one of the most exclusive in baseball history, with just two members. But on the 98th anniversary of Ty Cobb's 4,000th hit, Mike and Bill are joined by Sports Reference's Executive Director of Design, Negro Leagues expert and Latin baseball researcher Adam Darowski (@adarowski.bsky.social) to talk about his presentation at SABR 53, and how much larger that club actually is. The answer, and the players on it, will surprise you and hopefully expand your horizons about what should count toward the record book of baseball. Plus, happy birthday to Rubén Gómez and to Jesse Tannehill! And farewell to Mark Esser, Jack Curtis, Rod Nichols, and Jason Conti. Here's the link to the SABR 53 presentations, where you can find audio and slides from Adam's talk: https://sabr.org/convention/sabr53-presentations

¿Sabías que, en 1907, un médico midió 21 g al “peso del alma” justo en el instante de la muerte? ⚖️ Hoy no vamos a pesar almas, pero sí vamos a cartografiar la depresión: un vacío que, cuanto más hueco se vuelve, más pesa en nuestro día a día. En este episodio viajamos desde la leyenda de esos 21 gramos hasta la ciencia puntera de 2024, cuando la Universidad de Stanford identificó 6 biotipos cerebrales distintos de depresión y demostró que no todos los cerebros se deprimen igual. A lo largo de una hora de conversación combinamos historia, neurociencia y testimonios reales para iluminar: Qué es y qué NO es la depresión (spoiler: no es simple tristeza ni “falta de ganas”). Los factores biológicos, sociales y contextuales que la desencadenan y mantienen. El hallazgo de los marcadores cerebrales: desde la sobrecarga de la red por defecto (rumiación sin freno) hasta la “parálisis por análisis” de la corteza prefrontal. El biotipo “Insome” y cómo el insomnio desajusta tu reloj interno. El biotipo de la “Ola emocional”, donde la amígdala arde y cada estímulo se siente a 100 000 V. Estrategias prácticas: rTMS, ACT, DBT, cronoterapia, mindfulness… y cómo elegir la adecuada para TU biotipo. Te contaremos por qué Finlandia puede encabezar el ranking de países más felices y, aun así, luchar contra una tasa de suicidio elevada , y qué nos enseña eso sobre la diferencia entre “vida satisfactoria” y “bienestar emocional”. Al terminar el episodio: Sabrás describir tu propia experiencia con palabras precisas (¡o al menos sentirás que ya no estás solo!). Tendrás un mapa con las rutas terapéuticas mejor adaptadas a cada tipo de depresión. Contarás con una playlist de prácticas sencillas para activar tu ánimo incluso cuando la niebla sea densa. Recursos y comunidad (¡haz clic y acompáñanos!) Nuestro nuevo libro Nuestra escuela de ansiedad Visita nuestra web Facebook Instagram ▶️ YouTube AMADAG TV Palabras clave depresión,biotipos,Stanford,neurociencia,salud mental,21 gramos,Duncan MacDougall,DSM5,anhedonia,rutinas de sueño,rumiación,amígdala,corteza prefrontal,red por defecto,insomnio,terapia cognitiva,técnicas de mindfulness,ACT,TMS,antidepresivos,análisis neuroimagen,marcadores biológicos,La teoría de la mente,podcast psicología,AMADAG Hashtags #Depresión,#SaludMental,#Neurociencia,#LaTeoríaDeLaMente,#PodcastPsicología,#AMADAG 5 títulos atractivos para tu plataforma de podcasts 4 hábitos que te ayudarán a que la depresión pierda peso (¡y no son “pensar en positivo”!) ✨ Deja de luchar contra la tristeza así… y descubre por qué no funciona ⚠️ Esta forma de mirar tu cerebro cambiará para siempre el tratamiento de la depresión 5 cosas que nunca te contaron sobre la depresión… y que tu bienestar necesita saber ¿Y si tu tristeza fuera de otro “tipo”? Descubre el biotipo que está frenando tu ánimo ️ Pon los auriculares, pulsa play y acompáñanos en la investigación más humana de todas: la del alma que busca recuperar su luz.

Salmo 23:1-3

Dr. Beckett and Rich Klein dive into the intersections of baseball cards, baseball history, and sabermetrics. The episode covers valuable topics such as the evolution of card photography, the rarity and value of checklist cards, the differences in grading standards among major companies, and strategies for valuing personal collections. They also share anecdotes about the card industry and discuss how the COVID-19 pandemic and new market players have influenced the hobby's growth.   00:49 Challenges of the Card Market in the 80s 02:08 The Process Behind Baseball Card Photography 04:00 The Rarity and Value of Checklist Cards 04:38 Card Grading Standards and Market Perception 08:27 Advice for Valuing and Selling Your Collection 09:26 Impact of COVID-19 on Sports Card Collecting 11:05 Trend of One-of-One Cards 12:05 Interactions with Card Companies 13:22 Renata Galasso and Her Impact on the Hobby  

On Episode 985 of Hittin' Season, powered by WHYY, John Stolnis of The Good Phight, Justin Klugh from Baseball Prospectus and Liz Roscher, Editor of SABR's Baseball Research Journal, review the first half of the Phillies' 2025 season and wonder, how are the Phillies in first place? Also, John, Justin and Liz dive into a trivia challenge centered around the Philadelphia Phillies and their All-Star Game history, flowing through various milestones, memorable moments, and anecdotes from past All-Star Game. 00:00 Introduction and Overview of the Phillies' Season 02:40 Home Run Derby Highlights and Player Performances 05:28 Phillies' First Half Performance and Team Dynamics 08:42 Strengths and Weaknesses of the Phillies' Roster 11:37 Reflections on the First Half and Comparisons to Other Teams 14:46 Grading the Players: Starting Pitching and Offense 17:37 Bryce Harper's Impact and Expectations 20:33 Assessing the Bullpen and Overall Team Performance 23:30 Final Thoughts and All-Star Trivia 40:11 Trade Deadline Predictions 42:39 All-Star Game Trivia Fun 53:38 Milestones and Memorable Moments 59:16 All-Star Game Trivia Begins 01:02:18 Milestones and Historical Context 01:05:07 The Evolution of the Vet Stadium 01:07:43 Home Run Derby Highlights 01:11:31 Memorable All-Star Moments 01:15:17 Final Trivia Challenge and Wrap-Up

Dr. Beckett shares his remarks from the recent SABR Annual Convention #53. Along with Rich Klein and moderated by Paul Rogers, they delve into the evolution of sports card collecting, the transition from hobby to business, and the shifting dynamics within the industry. They discuss the changes in card pricing, the rise of modern cards, and the ongoing passion that drives collectors.   01:21 Early Days and Personal Journey 05:30 Challenges and Transitions 10:46 Evolution of the Hobby 14:05 Modern vs. Vintage Cards    

You can find a transcript of the episode hereOn this episode, our Mark Simon talks to Astros rookie right fielder Cam Smith, who ranks among the leaders in Defensive Runs Saved despite never having played the position before this season.Cam talked about his welcome to the big leagues' moments and explained how teammate Jake Meyers and the Astros outfield coaches have helped in his acclimation to a new position.Then, we switched topics. Mark went to the SABR convention and shared some of the things he learned, and brought on Sports-Reference's executive director of design Adam Darowski to share his research about players with 4,000 hits in pro baseball.Lastly, Mark and his colleague Ben Schneider talked about what SIS measures regarding home plate umpire performance and looked at some tendencies among MLB umpires the last couple of seasons.Three good interviews/discussions in roughly 20 minutes!Thanks as always for listening. Please check out the new-and-improved FieldingBible.com website, follow us on Bluesky at @sportsinfosolutions.com, and read our work at SportsInfoSolutions.com. You can e-mail us at Mark@sportsinfosolutions.com.

On Episode 982 of Hittin' Season, powered by WHYY, the Good Phight's John Stolnis, Justin Klugh of Baseball Prospectus and Liz Roscher from SABR's Baseball Research Journal discuss the historic pitching performance of Zack Wheeler and why the Phillies cannot waste his performance, and the starting rotation, by being passive at the trade deadline. Also, thoughts on All Stars Wheeler and Kyle Schwarber, snubs, and concerns over Bryce Harper's wrist continue.

Chapter on Patience (Sabr) - Lesson 6 by Albaseerah

With the boys still recovering from SABR last week in Dallas, it's a perfect time to revisit the great Larry Doby, who never gets nearly enough attention.  It's probably fair to say that no more important player in baseball history has been talked about less than Larry Doby, the second African-American to break the color line as a player and a manager, which happened 73 and 42 years ago this week, respectively. Mike and Bill try to rectify that just a little, looking back at Doby's life before getting the chance to integrate the American League and the incredible contributions he made after it. Plus, happy birthday to Al Downing and Tony Armas Sr! Back next week with a new episode.

Mike and Bill are off this week at SABR and are getting this classic episode up late. In that spirit, please enjoy this encore presentation of Episode 298: With the White Sox threatening to leave the Windy City and abscond to Tampa if they didn't get a new stadium 37 years ago this week, and with the Illinois legislative session winding down to the end of its session and the funding bill a few votes short, he weirdest thing happened. Time, on (and only on) the floor of the state legislature, stopped for three whole minutes, giving the Governor and House Majority Leader time to rally the support necessary to pass the bill. In honor of this miracle, of sorts, Mike and Bill look back at the history of the original Comiskey Park, and the hijinks that ultimately led to its replacement. Plus, happy birthday to Alejandro Peña and Howie Pollett!

On Episode 976 of Hittin' Season, powered by WHYY, John Stolnis of The Good Phight, Justin Klugh from Baseball Prospectus and SABR's Editor of the Baseball Research Journal, Liz Roscher, recap the Phillies' emphatic series win over the Mets this weekend. Is this now officially a two-team race in the NL East? Did the Phils make a statement with their two blowout wins? Also, John, Justin and Liz talk about which Phillies are deserving of an All Star nod.

On Episode 973 of Hittin' Season, powered by WHYY in Philadelphia, The Good Phight's John Stolnis, Justin Klugh of Baseball Prospectus and Liz Roscher from SABR's Baseball Research Journal react to the Phillies' sudden winning streak after Monday's 5-2 win over the Marlins. Pitching heroes, bats that are now hot and Orion Kerkering the new closer? Plus, a spirited debate over AI in baseball and the Rafael Devers trade!

En este episodio de expresiones hablamos de varias frases que contienen la palabra gracia. Sabrás por qué a las personas que ganan la lotería las llamamos agraciadas o por qué algo que tenga gracia no va a ser necesariamente positivo. Muchas gracias por escucharnos, si quieres acceder a ventajas y apoyar este podcast hazte suscriptor premium en: www.hoyhablamos.com Editar extracto

Let's learn the rest of our conjugations of Saber, as well as a few new conjugations of Haber, including the subjunctive and the preterite. Practice all of today's Spanish for free at LCSPodcast.com/77  

On Episode 966 of Hittin' Season, John Stolnis of The Good Phight, Liz Roscher, Editor of SABR's Baseball Research Journal and Baseball Prospectus' Justin Klugh gather together to discuss the many high points of the Phillies' 6-1 road trip. How much does it matter the level of competition wasn't great? Also, they preview this week's series against the Braves in Philly. Is Atlanta any good?

On Episode 963 of Hittin' Season, powered by WHYY in Philadelphia, John Stolnis from The Good Phight, SABR's Liz Roscher and Justin Klugh of Baseball Prospectus talk about Mick Abel's eye-opening MLB debut against the Pirates Sunday, and Jose Alvarado's shocking 80-game PED suspension that bars him from the 2025 postseason. Oh, and the Phils swept the Pirates, too.