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Dr. Lisa Hicks and Dr. Joseph Mikhael discuss the updated guideline from ASCO and Ontario Health (Cancer Care Ontario) on the treatment of multiple myeloma. They cover recommendations for therapeutic options across smoldering multiple myeloma, transplant eligible multiple myeloma, transplant ineligible multiple myeloma, and relapsed or refractory multiple myeloma. They highlight the importance of shared decision making and patient-centric care. They comment on the explosion of new treatment options in this space and the impetus for this guideline becoming a living guideline, which will be updated on an ongoing, regular basis. Read the full guideline, "Treatment of Multiple Myeloma: ASCO-Ontario Health (Cancer Care Ontario) Living Guideline" at www.asco.org/hematologic-malignancies-guidelines. TRANSCRIPT This guideline, clinical tools and resources are available at www.asco.org/hematologic-malignancies-guidelines. Read the full text of the guideline and review authors' disclosures of potential conflicts of interest in the Journal of Clinical Oncology,  https://ascopubs.org/doi/10.1200/JCO-25-02587   Brittany Harvey: Hello and welcome to the ASCO Guidelines podcast, one of ASCO's podcasts delivering timely information to keep you up to date on the latest changes, challenges, and advances in oncology. You can find all the shows, including this one, at asco.org/podcasts. My name is Brittany Harvey, and today I am interviewing Dr. Lisa Hicks from St. Michael's Hospital and University of Toronto, and Dr. Joseph Mikhael from the Translational Genomics Research Institute, an affiliate of City of Hope Cancer Center, co-chairs on "Treatment of Multiple Myeloma: American Society of Clinical Oncology-Ontario Health (Cancer Care Ontario) Living Guideline." Thank you for being here today, Dr. Hicks and Dr. Mikhael. Dr. Lisa Hicks: Thanks so much. Dr. Joseph Mikhael: It is a pleasure to be with you, Brittany. Thank you. Brittany Harvey: Before we discuss this guideline, I would like to note that ASCO takes great care in the development of its guidelines and ensuring that the ASCO Conflict of Interest Policy is followed for each guideline. The disclosures of potential conflicts of interest for the guideline panel, including Dr. Hicks and Dr. Mikhael who have joined us here today, are available online with the publication of the guideline in the Journal of Clinical Oncology, which is linked in the show notes. So then to dive into what we are here today to talk about, Dr. Mikhael, I would like to start by recognizing that this guideline updates the 2019 ASCO-CCO Guideline on the Treatment of Multiple Myeloma. So what prompted this update and what is the scope of this updated guideline? Dr. Joseph Mikhael: It is amazing when we think back in myeloma years, 2019 actually seems a very, very long time ago because really so much has changed in myeloma over these last six to seven years. Indeed, there have been over 150 randomized controlled trials that we didn't have at the prior guideline that we reviewed for this. Myeloma is a disease that has really changed so dramatically over these last several years. Multiple new agents have been introduced. We now have CAR-T cell therapy, bispecific antibodies, and multiple other agents that were not available at the time. Furthermore, with this growing complexity, it is becoming more important than ever to be able to provide practical advice and guidelines to the oncology community. For most oncologists, they have less than 5% of their time dedicated to multiple myeloma. It is important to bring a clarity to them that allows them to care for their patients. And the scope of these guidelines, furthermore, really cover the whole spectrum of myeloma. They go further than our prior guideline where now we have included smoldering multiple myeloma along with frontline therapy and relapsed multiple myeloma. So, we have really tried to provide the full spectrum to our colleagues in oncology to ensure that they have the tools they need to provide the best care possible for their patients. Dr. Lisa Hicks: That is a really terrific summary. And maybe one thing I will just add is it is really unique to have this much literature. I can't think of another guideline that I have ever been involved with that has seen a field move so quickly and develop so many advancements in a period of just over four or five years. Brittany Harvey: Certainly, there is a large volume of evidence that you all had to review for this guideline update. I think to your point probably one of the greater volumes of literature for a guideline update that you both mentioned. Based on that, I would like to review the key recommendations that are updated in this guideline. So Dr. Hicks, that new patient population that Dr. Mikhael mentioned earlier, what are the key recommendations for patients with smoldering multiple myeloma? Dr. Lisa Hicks: So this is the first time that an ASCO guideline is addressing this branch of multiple myeloma care. It is an area where I think some guidance is needed, and smoldering myeloma is not an active cancer. And so one thing that I really want to highlight is that the panel felt very strongly that to recommend any therapy in this space we needed a higher level of evidentiary certainty, of evidentiary confidence, to make recommendations for active therapy. The panel really made two very important recommendations. First of all, the panel did not recommend treatment for low or intermediate risk smoldering myeloma. That is important. And then the area where I think for the first time we have recommended consideration of treatment is patients with high risk smoldering myeloma. And for patients with high risk smoldering myeloma, the panel recommended that it was appropriate to consider either treatment with daratumumab or careful observation. Dr. Joseph Mikhael: And I think that move forward as you have mentioned, Dr. Hicks, is particularly important because it is an area to some degree still of equipoise and many trials are going on in the area. But we do now have a strong phase III trial that supports the use of daratumumab monotherapy for three years when compared to close observation. But of course, that is not for everyone. And one of the key themes of all of our recommendations are going to be now that more and more choices are available, that we have discussions with our patients to ensure that we match the right treatment with the preference of the patient. And I think that is particularly important here in smoldering myeloma. Dr. Lisa Hicks: Multiple myeloma care and the multiple myeloma evidence is really so nuanced, and one of the nuances that readers will appreciate if they read the guideline is that how smoldering myeloma is risk stratified has been different across different trials. And that really adds to the complexity of this recommendation and is one of the reasons that the panel felt that it was appropriate to recommend either observation or treatment. Brittany Harvey: It is great to have these new recommendations for this unique patient population. And as you both mentioned, that individualized patient care is really important across this entire guideline. So then following those recommendations, Dr. Mikhael, what is recommended for initial therapy, autologous stem cell transplantation, post transplant therapy, and measurement of response for patients with transplant eligible multiple myeloma? Dr. Joseph Mikhael: Well, that is an area that has really considerably also grown since the last guideline. Obviously one would have to consult the guidelines to get every last detail, but in essence, we want to assess whether or not patients are transplant eligible or ineligible. And that assessment is not based on age or renal function alone, but indeed on a careful assessment of that patient. When that assessment is made and deemed that a patient is transplant eligible, our recommendation is that a patient typically would receive a quadruplet. That is to say, a monoclonal antibody directed against CD38, a proteasome inhibitor, an immunomodulatory drug, and dexamethasone to be given for approximately four to six cycles followed by the stem cell transplant, followed by potentially another two cycles of consolidation, and then maintenance therapy. A couple of important caveats. One, we do have two different CD38 antibodies that can be used, either daratumumab or isatuximab. Although typically bortezomib is the preferred proteasome inhibitor, consideration can be given to carfilzomib by virtue of the potential toxicity from bortezomib. And then lastly in the maintenance setting, we are typically recommending at least lenalidomide alone, but consideration can be given to dual maintenance therapy as the data is emerging to either add to that daratumumab or carfilzomib. All the while using the IMWG criteria for response. The goal of course is to achieve the deepest response possible and to maintain that response until such time as patients would relapse. Finally, the length of maintenance therapy continues to be an area of equipoise and study in multiple myeloma. And so at minimum, patients would receive two to three years of maintenance therapy, and based on risk status and depth of response it can be considered that patients would potentially come off maintenance therapy, of course always with the caveat that toxicity would influence length of therapy as well. Brittany Harvey: Yes, as you mentioned, evaluating which patients are eligible is extremely important for considering what is recommended in the guideline for both transplant eligible and transplant ineligible patients. So then Dr. Hicks, following those recommendations for transplant eligible multiple myeloma, what are the recommended treatments, goals of therapy, and measurement of response for patients with transplant ineligible multiple myeloma? Dr. Lisa Hicks: You know, I really can't emphasize enough how important an individualized patient assessment is. When we are thinking about the range of patients that are included in this category of transplant ineligible patients, it is a huge range. You may have fairly fit patients in their late 70s all the way to patients in their 90s. And we really want to see that treatments are tailored both to the fitness of the patient, their individual circumstances, and their preferences. And it is a wonderful thing to have lots of options for patients in this circumstance. What the guidelines have recommended for most patients who are transplant ineligible but fit enough for a stronger therapy is quadruplet therapy. So actually therapy that is very similar to what is being recommended in the transplant eligible population but for a longer period of time. And then for those patients who for whatever reason, be it their fitness or their preference, are not appropriate for that quadruplet therapy, the recommendation is for triplet therapy with a combination of lenalidomide, bortezomib, dexamethasone, or very often, more often in most cases, an antibody based approach with an anti-CD38 plus lenalidomide plus dexamethasone. Dr. Joseph Mikhael: The only thing I would add to that, I think we have to also, as we do mention in our recommendations, be particularly cautious with the dosing of these medications. Because even though we think of them as a single agent or a particular class, there can be quite a variation within the dosing regimen that can affect a patient's side effects and their quality of life. And so being very careful with dose modifications, and particularly in the transplant ineligible patient, is an important part of the recommendation as well. Dr. Lisa Hicks: Yeah, this is a podcast so no one can see me nodding vigorously that dose modification is so important particularly with those older and frailer patients, and with particular attention to trying to reduce dexamethasone doses and favoring weekly administration of bortezomib when that drug is used. Brittany Harvey: Absolutely. Considering the risks and benefits and patient preferences is really key to selecting therapy for these patients. So then Dr. Mikhael, for the final overarching patient population addressed in this guideline, for patients with relapsed or refractory multiple myeloma, what treatment options are recommended? Dr. Joseph Mikhael: This of course is, if you will, the biggest part of the guideline because there has been so much done in the relapse setting. And I think we start the guideline by saying a decision has to be made as to when to institute therapy. That there may be some patients with slow biochemical relapse that may be monitored for a period of time. But when the decision is made to initiate treatment, instead of a simple algorithm, the guideline emphasizes the fact that there are multiple choices that can be given to a patient that are going to match what comorbidities the patient has, what they have been treated with before, and of course what their preferences are. I think we highlight two particular areas. That now that CAR-T cell therapy is available as early as first relapse, it should be a consideration by virtue of the fact that it has resulted in such deep and durable responses. But that triplets should also be considered in that earlier relapse setting because we do have multiple classes of agents that can be used. We know that in later relapse options exist including bispecific antibodies for which we have four different choices. And that in general, patients will ultimately receive either a triplet or CAR-T cell therapy in earlier relapse, but there are some patients who may be eligible only for a doublet by virtue of their comorbidities and of their prior therapies. Lastly, it really does emphasize the point as we have mentioned a few times in this podcast, and I am so glad it keeps coming up, is that as I often say we don't treat myeloma, we treat people. And engaging the patient in that conversation to ensure that the right treatment gets matched to the right patients is particularly important because with all the new classes that we have with antibody drug conjugates, with XPO1 inhibitors, the traditional three classes of proteasome inhibitors, immunomodulatory drugs, monoclonal antibodies, along with as we have already mentioned CAR-T and bispecific antibodies, it really is an incredible laundry list of choice. And making that choice specific to the patient becomes absolutely critical. I should also lastly note that there are patients who may defer their initial transplant. There may be patients who may be eligible for a second transplant. So autologous stem cell transplant, although primarily used in the frontline setting, may still be a consideration for a smaller subset of patients in the relapse setting. Dr. Lisa Hicks: I think maybe one thing that I would add is an overarching principle which is actually similar to a principle in the first guideline, and that is that in the relapsed or refractory setting, there are many different treatment options. And in fact, the number of treatment options feels like it is evolving every day. But an overarching principle for clinicians to consider is to try and choose combinations of drugs that the patient has either not been exposed to in the past or certainly that they are not refractory to. We really want to be pulling new options out of the toolbox as much as we can. Dr. Joseph Mikhael: Very often we do see where someone may be on a triplet and they are progressing on it and someone just changes out one drug. We have suggested not to take that approach but to take the approach of completely introducing a new therapy when someone is progressing on their current therapy. I think that point is particularly important and the consensus panel was very clear. Brittany Harvey: Understood. That is very helpful when thinking about what options to offer to patients in the relapsed and refractory setting. And as you mentioned earlier, the figures in this guideline provide an outline of options and then the tables really go into some of the details and outcomes of the trials, and those are very helpful for clinicians to refer to. So then Dr. Hicks, we have talked a little bit about some of the nuances of the guideline, but what should clinicians know as they implement these new and updated recommendations? Dr. Lisa Hicks: I think they should feel comfortable that these are trustworthy guidelines. So these are evidence-based guidelines that have been rigorously developed after a very thorough evidence review and put together by a panel of experts who were extremely thoughtful in their review of the evidence. And so all of this contributes to the trustworthiness of the guidance. And then I would also encourage people to take a deep look at the guidelines because of the importance of nuance that is addressed in them, and then to also explore some of the tools that ASCO is developing that helps with implementation including the flow charts that are contained within the guidelines and some additional tools that are available online. Brittany Harvey: Absolutely. The tools and resources for this guideline are available online with the publication and we will provide links to that in the show notes of the episode. So then following that, Dr. Mikhael, how does this guideline update affect patients with multiple myeloma? Dr. Joseph Mikhael: As we sort of intimated earlier, I like to say I don't treat myeloma, I treat people. I think we should always be patient-centric and patient-focused. And I think in the discussion we always were. We always wanted to ensure that multiple factors go into a decision-making process. We are not just looking at the biology of the disease, we are looking at patient factors. Those patient factors include their frailty as we commented in a frailty assessment, their preferences, their comorbidities. And I think, in a day where we have so many choices, we emphasize in the guideline the importance of that conversation with the patient. That, if you will, shared decision-making model where options are laid out and based on the patient factors and the treatment factors they can then be meshed together in the best way so that patients can make the right choice. And of course in conjunction with the guidelines, we have patient friendly summaries of them. And we involved, of course, patients in the development of these guidelines. And I think that is one of the greatest strengths of the ASCO guidelines is that there is a patient with us at the table who is giving their perspective on the guideline as we go forward. So I am very thankful that we have created a product that is, if you will, not only for the providers, the practitioners that are prescribing these agents and that are directly giving the care, but indeed for the very patients who of course have the most at stake here. Dr. Lisa Hicks: Yeah Joe, I am so glad you called out the participation of patient partners in the guideline. It is such an important part and they were really- the patient partner was such an important part of this panel in helping us understand the patient perspective as we developed this guidance. Brittany Harvey: Definitely. It is a hugely important role for the panel and for all of the panel including the patient partners and the experts in the disease to review the evidence and come up with comprehensive recommendations. And yes, as you mentioned, the individualized treatment and the shared decision-making is really paramount to this guideline. Finally, Dr. Hicks, you alluded to earlier the vast number of treatment options that is really exploding in multiple myeloma. And so this guideline is becoming a living guideline continuously updated by ASCO. So what are the outstanding questions regarding this topic and what evidence is the panel looking forward to for future updates? Dr. Lisa Hicks: I am really excited about this. This is one of the first guidelines that will be a living guideline for ASCO and it is such a good fit. You have heard Joe and I say a few times how quickly this field is moving, how complex the field is. I think everyone on the panel knew that no matter how quickly we did it and how deeply we reviewed the evidence, it was inevitable that more evidence would be generated as we were putting out the guideline. In a field like that, it is really important that we find a way to provide evidence-based guidelines quickly to the community. You know, waiting another five years, letting another 150 trials accrue before we do another guideline is not what the community needs. And so ASCO has really risen to this challenge and is committed to living guidelines. And so a living guideline is a guideline that commits to reviewing the evolving evidence on an ongoing basis, watching for practice changing trials, and having a standing panel that will review evidence and update recommendations on a regularly scheduled basis. So that is what a living guideline is, and that is what this guideline is becoming. That is just the first thing in terms of what a living guideline is. And then what are we watching? Well, honestly what aren't we watching? There is so much happening in multiple myeloma. We knew as we put the guideline out that there were trials in process, some trials that had been released at conferences but not yet published. We will be waiting for those and if they are practice changing they will be addressed in upcoming updates. There is new evidence just recently presented around combined anti-CD38 and bispecific antibodies. I don't know yet whether that will be addressed but I wouldn't be surprised if it was. There are so many things coming down the pipeline and it is just wonderful that there is going to be a way to try and address them in a robust fashion. Dr. Joseph Mikhael: Yeah I agree with you, Lisa. I can't think of another disease that would be more relevant for a living guideline. I mean we had difficulty because new data kept coming in as we were making recommendations. And so at some point we had to draw a line and say this is where we will stop and produce this guideline and have it ongoing. And I really look forward to seeing the updates because we know as you mentioned that there are so many things that are on the verge of approval and on the verge of changing the way we manage this terrible disease. And before I close, I would love to remind all of our listeners that as we commented from the start, patient engagement is critical at ASCO and in our guidelines process. Unfortunately we lost a very dear patient during the guidelines process, and that is Jack Aiello. Jack Aiello had been a patient and a patient advocate for many, many years in the myeloma community. And indeed we have actually dedicated these guidelines to his honor. And so I thought it would be valuable for us to mention that today. And we miss you Jack, but we are very grateful that we have been able to dedicate this excellent body of work to your memory. Brittany Harvey: Absolutely. This guideline and your dedication to him is an honor to his memory and we really recognize him in thinking about this guideline. We will look forward to those future trial results that you mentioned, Dr. Hicks, to update this guideline and continue to provide options for patients with multiple myeloma and improve upon those options and shared decision-making with patients. So I want to thank you both for all of your work to develop this guideline and for your time today, Dr. Hicks and Dr. Mikhael. Dr. Lisa Hicks: You are so welcome. Thanks for featuring this guideline. Dr. Joseph Mikhael: Thank you so much, Brittany. It has been a privilege. Brittany Harvey: Finally, thank you to all of our listeners for tuning in to the ASCO Guidelines podcast. To read the full guideline, go to www.asco.org/hematologic-malignancies-guidelines. You can also find many of our guidelines and interactive resources in the free ASCO Guidelines App, which is available in the  Apple App Store or the Google Play Store. If you have enjoyed what you have heard today, please rate and review the podcast and be sure to subscribe so you never miss an episode. The purpose of this podcast is to educate and to inform. This is not a substitute for professional medical care and is not intended for use in the diagnosis or treatment of individual conditions. Guests on this podcast express their own opinions, experience, and conclusions. Guest statements on the podcast do not express the opinions of ASCO. The mention of any product, service, organization, activity, or therapy should not be construed as an ASCO endorsement.  

Are your lab costs a little too high? In this episode, Kirk Behrendt brings back Robyn Theisen, one of ACT's amazing coaches, to continue the series on overhead and break down lab percentage. They explain what it is, how it impacts your practice, and what to do to maintain a healthy lab percentage. To learn how to lower your lab costs the smart way, listen to Episode 991 of The Best Practices Show!Learn More About Robyn:Send Robyn an email: robyn@actdental.com Follow Robyn on ACT's Instagram: https://www.instagram.com/actdentalSend Courtney an email to learn more about ACT: courtney@actdental.com More Helpful Links for a Better Practice & a Better Life:Subscribe to The Best Practices Show: https://the-best-practices-show.captivate.fm/listenJoin The Best Practices Association: https://www.actdental.com/bpaDownload ACT's BPA app on the Apple App Store: https://apps.apple.com/us/app/best-practices-association/id6738960360Download ACT's BPA app on the Google Play Store: https://play.google.com/store/apps/details?id=com.actdental.join&hl=en_USJoin ACT's To The Top Study Club: https://www.actdental.com/tttGet The Best Practices Magazine for free: https://www.actdental.com/magazinePlease leave us a review on the podcast:

Have you ever hired someone, then regretted it six months later? In this episode, Kirk Behrendt brings back Carlie Einarson, one of ACT's amazing coaches, to share four key types of interview questions that will help you prevent bad hires. To learn the most important step to finding the right people, listen to Episode 990 of The Best Practices Show!Learn More About Carlie:Send Carlie an email: carlie@actdental.com Follow Carlie on ACT's Instagram: https://www.instagram.com/actdentalSend Courtney an email to learn more about ACT: courtney@actdental.com More Helpful Links for a Better Practice & a Better Life:Subscribe to The Best Practices Show: https://the-best-practices-show.captivate.fm/listenJoin The Best Practices Association: https://www.actdental.com/bpaDownload ACT's BPA app on the Apple App Store: https://apps.apple.com/us/app/best-practices-association/id6738960360Download ACT's BPA app on the Google Play Store: https://play.google.com/store/apps/details?id=com.actdental.join&hl=en_USJoin ACT's To The Top Study Club: https://www.actdental.com/tttGet The Best Practices Magazine for free: https://www.actdental.com/magazinePlease leave us a review on the podcast:

Numbers tell a story, and you can use them to change your practice. In this episode, Kirk Behrendt brings back Robyn Theisen, one of ACT's amazing coaches, to share a few critical metrics that will make the biggest impact. To learn which data points to focus on to improve your practice, listen to Episode 989 of The Best Practices Show!Learn More About Robyn:Send Robyn an email: robyn@actdental.com Follow Robyn on ACT's Instagram: https://www.instagram.com/actdentalSend Courtney an email to learn more about ACT: courtney@actdental.com Send Gina an email to learn more about ACT: gina@actdental.com More Helpful Links for a Better Practice & a Better Life:Subscribe to The Best Practices Show: https://the-best-practices-show.captivate.fm/listenJoin The Best Practices Association: https://www.actdental.com/bpaDownload ACT's BPA app on the Apple App Store: https://apps.apple.com/us/app/best-practices-association/id6738960360Download ACT's BPA app on the Google Play Store: https://play.google.com/store/apps/details?id=com.actdental.join&hl=en_USJoin ACT's To The Top Study Club: https://www.actdental.com/tttGet The Best Practices Magazine for free: https://www.actdental.com/magazinePlease leave us a review on the podcast:

Rent and equipment is a huge part of overhead. But there are other costs hidden in those categories! In this episode, Kirk Behrendt brings back Robyn Theisen, one of ACT's amazing coaches, to continue the series on overhead and break down facilities and equipment percentage. To find out where else your money is being spent and how you can improve your overhead, listen to Episode 988 of The Best Practices Show!Learn More About Robyn:Send Robyn an email: robyn@actdental.comFollow Robyn on ACT's Instagram: https://www.instagram.com/actdentalSend Courtney an email to learn more about ACT: courtney@actdental.comSend Gina an email to learn more about ACT: gina@actdental.comMore Helpful Links for a Better Practice & a Better Life:Subscribe to The Best Practices Show: https://the-best-practices-show.captivate.fm/listenJoin The Best Practices Association: https://www.actdental.com/bpaDownload ACT's BPA app on the Apple App Store: https://apps.apple.com/us/app/best-practices-association/id6738960360Download ACT's BPA app on the Google Play Store: https://play.google.com/store/apps/details?id=com.actdental.join&hl=en_USJoin ACT's To The Top Study Club: https://www.actdental.com/tttGet The Best Practices Magazine for free: https://www.actdental.com/magazinePlease

In dieser neuen Podcast-Folge sprechen wir mit Kianimus über das Thema Fühlen und warum viele Menschen Schwierigkeiten damit haben, Emotionen richtig wahrzunehmen und auszudrücken. Gemeinsam mit meinem Gast schauen wir darauf, ob man „zu viel fühlen“ kann, ob Fühlen eine Schwäche ist und wie wir lernen können, Worte für unser inneres Erleben zu finden.Außerdem sprechen wir darüber, welche Rolle Bewegung im Coaching spielt und wie mehr Bewusstsein unsere Beziehungen verändern kann. Eine Folge voller reflektierter Gedanken, ehrlicher Einblicke und praktischer Impulse für den Alltag.Bücher von Kianimus:„Gute Menschen verlieren nie“ gibt es hier→ https://amzn.to/3NcdHt3„Wenn deine Frau..“ gibt es hier→ https://amzn.to/4eNnqnoKurse von Kianimus:„Wie verstehe ich meinen Mann“-Kurs:https://myablefy.com/s/kianimuscoaching/wie-verstehe-ich-meinen-mann/payment„Wie du dich wirklich selbst lieben lernst“-Kurs:https://myablefy.com/s/kianimuscoaching/selbstliebe-kurs/paymentSupport the show____________________________________________ Die Folge hat dir Lust auf mehr gegeben? Dann abonniere unseren Podcast und helfe uns mit einer 5-Sterne Bewertung auf Spotify & iTunes! Willst du unsern Podcast gerne im Videoformat sehen? Dann schaue dir alle Folgen in unserer App "MindClub" an!App Store: https://apps.apple.com/np/app/mind-club/id1643729107 Google Play Store: https://play.google.com/store/apps/details?id=tv.uscreen.mindclubOder auf Youtube: https://www.youtube.com/channel/UCFg1XNY1KVcb1WQWbcKCmOQ/featuredWillst du selbst mit dem Meditieren beginnen? Im Mindclub findest du eine Vielzahl von geführten Meditationen in Audio- und Videoform, sowie Live-Sessions: https://www.mindclubapp.com/Instagram: https://www.instagram.com/mindfulife.de/Facebook: ...

Do you dream of running a successful practice? Then core values aren't optional! In this episode, Kirk Behrendt brings back Heather Crockett, one of ACT's amazing coaches, to share why core values are critical and how to do them the right way. Don't just paste your values on the walls! To learn how to keep them alive in your halls, listen to Episode 987 of The Best Practices Show!Learn More About Heather:Send Heather an email: heather@actdental.com Join Heather on Facebook: https://www.facebook.com/heather.r.crockettFollow Heather on ACT's Instagram: https://www.instagram.com/actdentalSend Gina an email to learn more about ACT: gina@actdental.com More Helpful Links for a Better Practice & a Better Life:Subscribe to The Best Practices Show: https://the-best-practices-show.captivate.fm/listenJoin The Best Practices Association: https://www.actdental.com/bpaDownload ACT's BPA app on the Apple App Store: https://apps.apple.com/us/app/best-practices-association/id6738960360Download ACT's BPA app on the Google Play Store: https://play.google.com/store/apps/details?id=com.actdental.join&hl=en_USJoin ACT's To The Top Study Club: https://www.actdental.com/tttGet The Best Practices Magazine for free:

This week, Marianna sits down with John Faragon to go over some of this year's highlights in the world of HIV care. Tune in to hear all about new drug regimens, updated guidelines, and more. -- Resources in this episode: Guidelines for the Use of Antiretroviral Agents in Adults & Adolescents with HIV: https://clinicalinfo.hiv.gov/en/guidelines/hiv-clinical-guidelines-adult-and-adolescent-arv/whats-new2025 Update of the Drug Resistance Mutationsin HIV-1: https://www.iasusa.org/wp-content/uploads/2025/03/33-2-mutations.pdfClinical Recommendation for the Use of Injectable Lenacapavir as HIV PrEP: https://www.cdc.gov/mmwr/volumes/74/wr/mm7435a1.htmAntiretroviral Postexposure Prophylaxis after Sexual, Injection Drug Use, or Other Nonoccupational Exposure to HIV: https://www.cdc.gov/mmwr/volumes/74/rr/rr7401a1.htm-- Help us track the number of listeners our episode gets by filling out this brief form! (https://www.e2NECA.org/?r=AQX7941)--Want to chat? Email us at podcast@necaaetc.org with comments or ideas for new episodes. --Check out our free online courses: www.necaaetc.org/rise-courses--Download our HIV mobile apps:Google Play Store: https://play.google.com/store/apps/developer?id=John+Faragon&hl=en_US&gl=USApple App Store: https://apps.apple.com/us/developer/virologyed-consultants-llc/id1216837691

Everyone from your kids to your vet is using AI. But how should you use it in your dental practice? In this episode, Kirk Behrendt brings back Travis Wentworth, cybersecurity expert from Intelligence Quest, to share some best practices that you and your dental team should know when using AI. To learn about the precautions to take to keep your patients and practice safe, listen to Episode 986 of The Best Practices Show!Learn More About Travis:Follow Travis on Instagram: https://www.instagram.com/travis_iqJoin Travis on Twitter: https://x.com/travisiqLearn more about Intelligence Quest: https://intelligencequest.comWatch Intelligence Quest on YouTube: https://www.youtube.com/@intelligencequestMore Helpful Links for a Better Practice & a Better Life:Subscribe to The Best Practices Show: https://the-best-practices-show.captivate.fm/listenJoin The Best Practices Association: https://www.actdental.com/bpaDownload ACT's BPA app on the Apple App Store: https://apps.apple.com/us/app/best-practices-association/id6738960360Download ACT's BPA app on the Google Play Store: https://play.google.com/store/apps/details?id=com.actdental.join&hl=en_USJoin ACT's To The Top Study Club: https://www.actdental.com/tttGet The Best Practices Magazine for free:

Rick is joined by Daren Hornig of CourtsApp. CourtsApp, the first AI-powered marketing and booking platform built to modernize court marketing and reservations across the red-hot racquet sports industry, has announced its official launch throughout the New York tri-state area. Founded by New York entrepreneur and real estate developer Daren Hornig and creative executive Kate Daggett, CourtsApp is designed to eliminate the frustration and friction that have long plagued the tennis and pickleball communities, making it now seamless and easy to reserve a court in any racquet and paddle sport. CourtsApp also helps facilities grow. By making every court discoverable and bookable, the platform turns unused inventory into real revenue and delivers a steady stream of high-intent players to clubs. With seamless integrations with existing court management systems, full control over pricing and rules, CourtsApp gives operators a simple and efficient way to fill courts and expand their reach. CourtsApp provides its software to the facilities for free and makes a commission on the courts it books. Currently live to players with more than 1,500 courts across 150+ facilities already signed on throughout New York, New Jersey, and Connecticut, CourtsApp will expand from Maine to Florida by the first quarter of 2026 before expanding market-by-market as club density increases. Additional play-in markets, including Southern California, Texas, and the Pacific Northwest, are expected to come online throughout 2026. Clubs such as the John McEnroe Academy's flagship location at Sportime Randalls Island, Pickleball America, Padel Haus, all Sportime Pickleball locations and more are currently available for players to reserve courts. “CourtsApp was born from pure frustration,” said Hornig, Chief Executive Officer of CourtsApp and an avid tennis and pickleball player. “For years, me and my friends struggled to find open courts in real time and near where I wanted to play. We wanted a simple, reliable solution that matched how people already book restaurants, travel, or fitness. Now, with CourtsApp, they finally have one.” Hornig called CourtsApp the “OpenTable for courts. The Expedia of racquet sports,” and added, “Beyond convenience, CourtsApp connects people; helping friends meet to play, helping communities stay active, and making racquet sports more accessible to everyone. It is also a critical marketing tool for facility owners. Most operators lack the funds and expertise to market effectively in today’s complex digital environment, and CourtsApp does this for them and more. Our goal is to get players on the courts and help clubs keep their courts full. It's really a win-win scenario for all.” Daggett, CourtsApp's Chief Marketing Officer, resides in Connecticut and, like Hornig, is among the 25.7 million Americans who played tennis in 2024, according to the most recent statistics reported by the United States Tennis Association (USTA), which was an all-time high and a surge of 1.9 million more than 2023. Pickleball has been consistently named the fastest-growing sport in the nation with an estimated 22.7 million players, an increase of more than 45 percent over the previous year. There are more than 68,000 dedicated pickleball courts in the U.S. “Racquet sports are booming, but the technology that supports them has not kept up,” commented Daggett. “Players expect the same ease they get everywhere else, and clubs need tools that help them grow. CourtsApp brings both sides together in a modern, intuitive experience that gets more people on the court, more often.” CourtsApp is also forging integrations with the leading court-management systems nationwide, enabling instant court bookings at participating facilities. CourtsApp is continuing to roll out integrations with leading pickleball and racquet-sport technology platforms. One of the first is DUPR, the pickleball rating system used by more than 1.6 million players and 8,000 clubs. This integration will allow players to bring their verified rating directly into the CourtsApp ecosystem and for players to book courts within DUPR. A Win for Both Players and Clubs For clubs, CourtsApp functions as a free, performance-based marketing channel. Facilities can join at no cost, with CourtsApp earning a commission on court time bookings. For players, CourtsApp provides: Easy search functions across tennis, pickleball, padel facilities, as well as table tennis, squash, badminton and racquetball Real-time booking confirmations Map View Secure payment via Stripe and Apple Pay A familiar, “OpenTable-style” user experience Players and clubs can learn more or join the platform at CourtsApp.com and download CourtsApp from the Apple App Store for iOS and Google Play Store for Android. Also… A Smarter Match: CourtsApp and DUPR Form Partnership To Power Verified Pickleball Play Everywhere Local Courts to Access National-Level Ranking Infrastructure, Building a More Connected Pickleball Ecosystem Where Every Match Counts CourtsApp also announced a strategic partnership with DUPR (Dynamic Universal Pickleball Rating), the global standard for pickleball ratings and verified match data. Together, the companies are building a more connected ecosystem for racquet sports, one where every match can count toward verified player progress and help clubs attract more engaged, repeat players. DUPR and CourtsApp share a common mission: reduce friction for players and facilities by connecting access, performance, and community in one integrated environment. “DUPR has become the gold standard for measuring skill in pickleball, and together we're making that progress visible right where the game happens, on the court,” said Daren Hornig, CourtsApp founder and CEO. “Clubs are the engine of that growth, and as CourtsApp continues expanding from the NY Tristate area into new markets in 2026, our work with more than 150 clubs and 1,500 courts shows how verified play helps clubs boost utilization and revenue without changing how they operate.” Through this partnership, CourtsApp will integrate DUPR's universal rating system directly into its platform, enabling players to: • Connect DUPR accounts through CourtsApp • Book courts on DUPR, powered by CourtsApp's real-time availability engine • Record match results automatically, creating verified rating histories • Receive enhanced matchmaking and performance insights over time For racquet sport facilities, the CourtsApp-DUPR collaboration unlocks new opportunities to: • Seamlessly integrate CourtsApp's AI-driven marketing and booking tools across 8,000-plus DUPR partner facilities nationwide • Host DUPR-eligible matches and Open Plays • Tap into DUPR's 1.5 million engaged pickleball players to drive visibility and participation • Leverage data-driven insights to boost pickleball court utilization and player retention • Drive incremental revenue as DUPR-engaged players seek more opportunities to play and log verified matches DUPR CEO Tio Machado said that CourtsApp is building the digital infrastructure that helps the sport grow. “We're excited to align on the shared mission of connecting players and verified play everywhere,” he said. Hornig added that when CourtsApp evaluates partnerships, the focus is on partnering with the very best companies in their respective spaces. “The alignment with DUPR is a trifecta as they work with facilities and players, which is the exact audience that CourtsApp focuses on, and within the CourtsApp platform we're able to add DUPR's rating to our expanding network of players,” he explained. Integration work is already underway, with new functionality expected to launch in an upcoming product release. The partnership represents a pivotal step toward a unified racquet sport ecosystem that connects access, performance, community, and technology while helping clubs grow with rising demand for verified play. DUPR announced it was partnering with USA Pickleball as the official ratings system of all USA Pickleball-owned events. CourtsApp is available for free in the northeastern United States with more than 150 facilities and 1,500 courts onboarded and accepting bookings for tennis, pickleball and padel courts. CourtsApp will extend from Maine to Florida by the first quarter of 2026 before expanding market-by-market as club density increases. Additional play-in markets, including Southern California, Texas, and the Pacific Northwest, are expected to come online throughout 2026.

Thank you for joining us! To stay connected with us visit us here, on SoundCloud and on: Website: https://www.mynpmc.com/ Facebook: https://www.facebook.com/mynpmc YouTube: https://www.youtube.com/channel/UCnOiemCev_mHyZNgU2QgwnA Download the NPMC app on the: Google Play Store: https://play.google.com/store/apps/details?id=com.echurchapps.newparis&hl=en_US Apple App Store: https://apps.apple.com/us/app/new-paris-missionary-church/id1228753320 Give Online: https://pushpay.com/g/newparismissionarychurch New Paris Missionary Church is located in New Paris, Indiana. We would love for you to join us in person or online on Sundays as we worship God together. Our service begins at 10:00 a.m. We hope to see you soon!

It's that festive time of year, but roughly 50% of the Geek Salad crew aren't feeling all that festive. So in this episode, they bring you their holiday cheer and holiday agita! It's a great way to take stock of the horrific hellscape of 2025 with a look at both the Naughty and the Nice! Geek Salad is available at www.geeksalad.podbean.com, or can be subscribed to at the iTunes store by using keyword “geek salad.”  Geek Salad is also available on Spotify,iTunes,  iHeart Radio and wherever else you get your podcasts! Also, check out the Podbean App where you can stream and download the entire Geek Salad archive right from your Android or iPhone!  You can get the app at either the Google Play Store or the Apple App Store!  Want Geek Salad swag?  Check out our new store on Tee Public, where you can get t-shirts, mugs, stickers, and so much other stuff!!!  Shop here! Geek Salad episodes are now also available to stream on YouTube.  “Like” and Subscribe to their channel at Geek Salad Podcast at www.youtube.com Contact Geek Salad at geeksaladradio@gmail.com.  Geek Salad is also available on Facebook under the group heading “Geek Salad Podcast.” Check out their website at www.geek-salad.com, and please subscribe to their Blue Sky feed: @geeksaladradio Geek Salad is intended for adult listeners and contains coarse language and profanity.  Listener discretion is advised.  

You buy cheaper cotton rolls and the cheapest gloves. But your operational overhead is still too high! In this episode, Kirk Behrendt brings back Miranda Beeson, ACT's director of education, to continue the series on overhead and break down operations percentage. Buying cheap supplies won't help your practice! To learn about the hidden costs that are impacting your overhead, listen to Episode 985 of The Best Practices Show!Learn More About Miranda:Send Miranda an email: miranda@actdental.comFollow Miranda on ACT's Instagram: https://www.instagram.com/actdentalSend Gina an email to learn more about ACT: gina@actdental.comMore Helpful Links for a Better Practice & a Better Life:Subscribe to The Best Practices Show: https://the-best-practices-show.captivate.fm/listenJoin The Best Practices Association: https://www.actdental.com/bpaDownload ACT's BPA app on the Apple App Store: https://apps.apple.com/us/app/best-practices-association/id6738960360Download ACT's BPA app on the Google Play Store: https://play.google.com/store/apps/details?id=com.actdental.join&hl=en_USJoin ACT's To The Top Study Club: https://www.actdental.com/tttGet The Best Practices Magazine for free: https://www.actdental.com/magazinePlease leave us a review on the podcast:

On Dec. 10, it was announced that Google would pay nearly $700 million in settlements to people who paid to download apps from the Google Play Store.The announcement came in the form of a statement from multiple state attorneys general, who were collectively suing Google for anti-competitive practices.Google decided to settle this lawsuit—along with several other concessions—and, in so doing, will pay $700 million, the bulk of which will go to the actual users.Let's go through the details of the case: what Google was accused of doing, how the settlement money will be disbursed, and how you can know if you qualify.

Things happen, and your team will be late or absent. But when does it become a problem, and what can you do about it? In this episode, Kirk Behrendt brings back Alan Twigg, president of Bent Ericksen & Associates, to help you navigate and address chronic attendance issues that are happening in your practice. To learn how to get your team to show up for you and your patients, listen to Episode 984 of The Best Practices Show!Learn More About Alan:Give Alan a call: (800) 679-2760Send Alan an email: alan@bentericksen.com Join Bent Ericksen on Facebook: https://www.facebook.com/BentEricksenAssociatesLearn more about Bent Ericksen: https://bentericksen.comMore Helpful Links for a Better Practice & a Better Life:Subscribe to The Best Practices Show: https://the-best-practices-show.captivate.fm/listenJoin The Best Practices Association: https://www.actdental.com/bpaDownload ACT's BPA app on the Apple App Store: https://apps.apple.com/us/app/best-practices-association/id6738960360Download ACT's BPA app on the Google Play Store: https://play.google.com/store/apps/details?id=com.actdental.join&hl=en_USJoin ACT's To The Top Study Club: https://www.actdental.com/tttGet The Best Practices Magazine for free: https://www.actdental.com/magazinePlease leave us a review on the podcast: https://podcasts.apple.com/us/podcast/the-best-practices-show-with-kirk-behrendt/id1223838218Episode Resources:Watch the video version of Episode 984: https://www.youtube.com/@actdental/videosMain Takeaways:Understand your state, county, and city rules around attendance, sick leave, and PTO.When you don't address chronic attendance issues, your good employees will leave.Avoid creating policies that are too strict or rigid. They will come back to bite you.Know the requirements, limitations, and nuances around getting doctor's notes.Always document your employees' reasons for tardies and absences.Snippets:0:00 Introduction.1:38 Alan's background.2:26 Why this is an important topic.3:55 Mandatory sick leave, explained.6:16 Document the reason for an absence.9:46 Things to know about requiring doctor's notes.13:00 Attendance, sick leave, and PTO policies.15:22 Categorize the reasons for absences and tardies.17:52 Let them use their time.20:34 Don't solve your team members' problems.23:50 Your employee says they're sick, but . . .27:02 Leave of absence, explained.28:02 Being chronically late versus...

The year 2025 was a mixed blessing for FC Cincinnati fans, but there's always more promise on the horizon. As much as the Orange & Blue left points on the table, they were still much closer to success than the 2024 season provided. However, 2026 is already weeks away, bringing with it big challenges for both club and country. What can Cincinnati do to build for the next year? What teams have already started to pack their shopping carts with talent? And while we're at it, how does the recent World Cup draw look for all of its qualified teams? We mosey up to a table with our special guest Tom Bogert from The Athletic and Soccerwise to close the book on the past season and open the next for 2026. What teams does Tommy Scoops see capitalizing on the transfer market? Tune in and trade threads with us! #MLS #FCCincinnati #soccer Become a Patron! Subscribe to Cincinnati Soccer Talk Don't forget you can now download and subscribe to Cincinnati Soccer Talk on iTunes today! The podcast can also be found on Stitcher Smart Radio now. We're also available in the Google Play Store and NOW ON SPOTIFY! As always we'd love your feedback about our podcast! You can email the show at feedback@cincinnatisoccertalk.com. We'd love for you to join us on our Facebook page as well! Like us at Facebook.com/CincinnatiSoccerTalk.

We were inundated with new Windows features in 2025, but which ones actually moved the needle? Fortnite isn't just back on iPhone and Android, it's available on Windows 11 on Arm, and it works great! Plus, 2 big mobile wins for Epic Games and some thoughts on the "right" way to roll out AI features.Windows 11 Best Windows 11 updates of 2025, in no particular order... Dark mode improvements to File Explorer Widgets major overhaul with separate widgets and Discovery feed Xbox Full Screen experience - especially good on handhelds, of course, but also any PC you use for gaming with a controller Click to Do (Copilot+ PC only) External fingerprint reader support for Windows Hello ESS -External/USB webcams supported by Windows Studio Effects (Copilot+ PC only) Quick Machine Recovery is the tip of a wave of new foundational features like Admin Protection, Smart App Control (updates), and more that go beyond surface-level look and feel Redesigned Start menu isn't perfect but it's a nice improvement Copilot Vision, though this type of thing may make more sense on phones AI features in Paint, Photos, Notepad, and Snipping Tool Natural language interactions like the agent in Settings, file search, and more (mostly Copilot+ PC only, but you can do this in Copilot as well) Bluetooth LE support for improved audio quality in game chat, voice calls Gaming on Windows 11 on Arm and Snapdragon X: Major steps forward, but the same issue as always Looking ahead to 2026: 26H1, Agentic features that work, potential Windows 12, and AI PCs AI An extensive new interview with Mustafa Suleyman confirms why this guy is special and how confusing it is that Copilot is so disrespected Microsoft Copilot is auto-installing on LG smart TVs and there's no way to remove it GPT-5.2 is OpenAI's answer to Gemini 3 ChatGPT Images is OpenAI's answer to Nano Banana Pro Disney invests $1 billion OpenAI, sues Google Opera Neon is now generally available for $20 per month AI is moving quick as we all know but the bigger issue may be the incessant marketing about features like agents that don't even work now Microsoft is getting pushback on forced Copilot usage, price hikes Google is expanding its use of "experiments" outside of mainstream products with things like NotebookLM, Mixboard, CC, and much more. Maybe this is the better approach: Test separately and then integrate it into existing products Oddly enough, Microsoft does have a Windows AI Lab for this kind of experimentation Many small models vs. one big LLM in the cloud Mobile Fortnite is back in the Google Play Store in the U.S. as Google plays nice Apple loses its contempt appeal, the end of "junk fees" (Apple Tax) is in sight Xbox and gaming Xbox December Update has one big update for the mobile app and one big update for Xbox Wireless Headphones There's a new Xbox Developer Direct coming in January Half-Life 3 may really be happening, but it will be a Steam Machine launch title so it could be a while Tips & picks Tip of the year: De-enshittify Windows 11 App pick of the year: Fortnite RunAs Radio this week: Zero Trust in 2026 with Michele Bustamante Brown liquor pick of the week: Lark Symphony No. 1 These show notes have been truncated due to length. For the full show notes, visit https://twit.tv/shows/windows-weekly/episodes/963 Hosts: Leo Laporte, Paul Thurrott, and Richard Campbell Sponsors: auraframes.com/ink framer.com/design promo code WW outsystems.com/twit cachefly.com/twit

We were inundated with new Windows features in 2025, but which ones actually moved the needle? Fortnite isn't just back on iPhone and Android, it's available on Windows 11 on Arm, and it works great! Plus, 2 big mobile wins for Epic Games and some thoughts on the "right" way to roll out AI features.Windows 11 Best Windows 11 updates of 2025, in no particular order... Dark mode improvements to File Explorer Widgets major overhaul with separate widgets and Discovery feed Xbox Full Screen experience - especially good on handhelds, of course, but also any PC you use for gaming with a controller Click to Do (Copilot+ PC only) External fingerprint reader support for Windows Hello ESS -External/USB webcams supported by Windows Studio Effects (Copilot+ PC only) Quick Machine Recovery is the tip of a wave of new foundational features like Admin Protection, Smart App Control (updates), and more that go beyond surface-level look and feel Redesigned Start menu isn't perfect but it's a nice improvement Copilot Vision, though this type of thing may make more sense on phones AI features in Paint, Photos, Notepad, and Snipping Tool Natural language interactions like the agent in Settings, file search, and more (mostly Copilot+ PC only, but you can do this in Copilot as well) Bluetooth LE support for improved audio quality in game chat, voice calls Gaming on Windows 11 on Arm and Snapdragon X: Major steps forward, but the same issue as always Looking ahead to 2026: 26H1, Agentic features that work, potential Windows 12, and AI PCs AI An extensive new interview with Mustafa Suleyman confirms why this guy is special and how confusing it is that Copilot is so disrespected Microsoft Copilot is auto-installing on LG smart TVs and there's no way to remove it GPT-5.2 is OpenAI's answer to Gemini 3 ChatGPT Images is OpenAI's answer to Nano Banana Pro Disney invests $1 billion OpenAI, sues Google Opera Neon is now generally available for $20 per month AI is moving quick as we all know but the bigger issue may be the incessant marketing about features like agents that don't even work now Microsoft is getting pushback on forced Copilot usage, price hikes Google is expanding its use of "experiments" outside of mainstream products with things like NotebookLM, Mixboard, CC, and much more. Maybe this is the better approach: Test separately and then integrate it into existing products Oddly enough, Microsoft does have a Windows AI Lab for this kind of experimentation Many small models vs. one big LLM in the cloud Mobile Fortnite is back in the Google Play Store in the U.S. as Google plays nice Apple loses its contempt appeal, the end of "junk fees" (Apple Tax) is in sight Xbox and gaming Xbox December Update has one big update for the mobile app and one big update for Xbox Wireless Headphones There's a new Xbox Developer Direct coming in January Half-Life 3 may really be happening, but it will be a Steam Machine launch title so it could be a while Tips & picks Tip of the year: De-enshittify Windows 11 App pick of the year: Fortnite RunAs Radio this week: Zero Trust in 2026 with Michele Bustamante Brown liquor pick of the week: Lark Symphony No. 1 These show notes have been truncated due to length. For the full show notes, visit https://twit.tv/shows/windows-weekly/episodes/963 Hosts: Leo Laporte, Paul Thurrott, and Richard Campbell Sponsors: auraframes.com/ink framer.com/design promo code WW outsystems.com/twit cachefly.com/twit

We were inundated with new Windows features in 2025, but which ones actually moved the needle? Fortnite isn't just back on iPhone and Android, it's available on Windows 11 on Arm, and it works great! Plus, 2 big mobile wins for Epic Games and some thoughts on the "right" way to roll out AI features.Windows 11 Best Windows 11 updates of 2025, in no particular order... Dark mode improvements to File Explorer Widgets major overhaul with separate widgets and Discovery feed Xbox Full Screen experience - especially good on handhelds, of course, but also any PC you use for gaming with a controller Click to Do (Copilot+ PC only) External fingerprint reader support for Windows Hello ESS -External/USB webcams supported by Windows Studio Effects (Copilot+ PC only) Quick Machine Recovery is the tip of a wave of new foundational features like Admin Protection, Smart App Control (updates), and more that go beyond surface-level look and feel Redesigned Start menu isn't perfect but it's a nice improvement Copilot Vision, though this type of thing may make more sense on phones AI features in Paint, Photos, Notepad, and Snipping Tool Natural language interactions like the agent in Settings, file search, and more (mostly Copilot+ PC only, but you can do this in Copilot as well) Bluetooth LE support for improved audio quality in game chat, voice calls Gaming on Windows 11 on Arm and Snapdragon X: Major steps forward, but the same issue as always Looking ahead to 2026: 26H1, Agentic features that work, potential Windows 12, and AI PCs AI An extensive new interview with Mustafa Suleyman confirms why this guy is special and how confusing it is that Copilot is so disrespected Microsoft Copilot is auto-installing on LG smart TVs and there's no way to remove it GPT-5.2 is OpenAI's answer to Gemini 3 ChatGPT Images is OpenAI's answer to Nano Banana Pro Disney invests $1 billion OpenAI, sues Google Opera Neon is now generally available for $20 per month AI is moving quick as we all know but the bigger issue may be the incessant marketing about features like agents that don't even work now Microsoft is getting pushback on forced Copilot usage, price hikes Google is expanding its use of "experiments" outside of mainstream products with things like NotebookLM, Mixboard, CC, and much more. Maybe this is the better approach: Test separately and then integrate it into existing products Oddly enough, Microsoft does have a Windows AI Lab for this kind of experimentation Many small models vs. one big LLM in the cloud Mobile Fortnite is back in the Google Play Store in the U.S. as Google plays nice Apple loses its contempt appeal, the end of "junk fees" (Apple Tax) is in sight Xbox and gaming Xbox December Update has one big update for the mobile app and one big update for Xbox Wireless Headphones There's a new Xbox Developer Direct coming in January Half-Life 3 may really be happening, but it will be a Steam Machine launch title so it could be a while Tips & picks Tip of the year: De-enshittify Windows 11 App pick of the year: Fortnite RunAs Radio this week: Zero Trust in 2026 with Michele Bustamante Brown liquor pick of the week: Lark Symphony No. 1 These show notes have been truncated due to length. For the full show notes, visit https://twit.tv/shows/windows-weekly/episodes/963 Hosts: Leo Laporte, Paul Thurrott, and Richard Campbell Sponsors: auraframes.com/ink framer.com/design promo code WW outsystems.com/twit cachefly.com/twit

We were inundated with new Windows features in 2025, but which ones actually moved the needle? Fortnite isn't just back on iPhone and Android, it's available on Windows 11 on Arm, and it works great! Plus, 2 big mobile wins for Epic Games and some thoughts on the "right" way to roll out AI features.Windows 11 Best Windows 11 updates of 2025, in no particular order... Dark mode improvements to File Explorer Widgets major overhaul with separate widgets and Discovery feed Xbox Full Screen experience - especially good on handhelds, of course, but also any PC you use for gaming with a controller Click to Do (Copilot+ PC only) External fingerprint reader support for Windows Hello ESS -External/USB webcams supported by Windows Studio Effects (Copilot+ PC only) Quick Machine Recovery is the tip of a wave of new foundational features like Admin Protection, Smart App Control (updates), and more that go beyond surface-level look and feel Redesigned Start menu isn't perfect but it's a nice improvement Copilot Vision, though this type of thing may make more sense on phones AI features in Paint, Photos, Notepad, and Snipping Tool Natural language interactions like the agent in Settings, file search, and more (mostly Copilot+ PC only, but you can do this in Copilot as well) Bluetooth LE support for improved audio quality in game chat, voice calls Gaming on Windows 11 on Arm and Snapdragon X: Major steps forward, but the same issue as always Looking ahead to 2026: 26H1, Agentic features that work, potential Windows 12, and AI PCs AI An extensive new interview with Mustafa Suleyman confirms why this guy is special and how confusing it is that Copilot is so disrespected Microsoft Copilot is auto-installing on LG smart TVs and there's no way to remove it GPT-5.2 is OpenAI's answer to Gemini 3 ChatGPT Images is OpenAI's answer to Nano Banana Pro Disney invests $1 billion OpenAI, sues Google Opera Neon is now generally available for $20 per month AI is moving quick as we all know but the bigger issue may be the incessant marketing about features like agents that don't even work now Microsoft is getting pushback on forced Copilot usage, price hikes Google is expanding its use of "experiments" outside of mainstream products with things like NotebookLM, Mixboard, CC, and much more. Maybe this is the better approach: Test separately and then integrate it into existing products Oddly enough, Microsoft does have a Windows AI Lab for this kind of experimentation Many small models vs. one big LLM in the cloud Mobile Fortnite is back in the Google Play Store in the U.S. as Google plays nice Apple loses its contempt appeal, the end of "junk fees" (Apple Tax) is in sight Xbox and gaming Xbox December Update has one big update for the mobile app and one big update for Xbox Wireless Headphones There's a new Xbox Developer Direct coming in January Half-Life 3 may really be happening, but it will be a Steam Machine launch title so it could be a while Tips & picks Tip of the year: De-enshittify Windows 11 App pick of the year: Fortnite RunAs Radio this week: Zero Trust in 2026 with Michele Bustamante Brown liquor pick of the week: Lark Symphony No. 1 These show notes have been truncated due to length. For the full show notes, visit https://twit.tv/shows/windows-weekly/episodes/963 Hosts: Leo Laporte, Paul Thurrott, and Richard Campbell Sponsors: auraframes.com/ink framer.com/design promo code WW outsystems.com/twit cachefly.com/twit

Insurance can be frustrating to figure out on your own. In this episode, Kirk Behrendt brings back Shelley DeGroff, founder of PPO Advisors, to decode some of the biggest changes in the PPO world and share two things you need to do to improve your reimbursements in the upcoming year. To stay up to date with PPO changes and prevent future revenue loss, listen to Episode 983 of The Best Practices Show!Learn More About Shelley:Send Shelley an email: shelley@ppoadvisors.com Join PPO Advisors on Facebook: https://www.facebook.com/PPOAdvisorsLLCLearn more about PPO Advisors: https://ppoadvisors.comMention this episode or visit this link to receive $500 off your analysis fee: https://learn.ppoadvisors.com/promoMore Helpful Links for a Better Practice & a Better Life:Subscribe to The Best Practices Show: https://the-best-practices-show.captivate.fm/listenJoin The Best Practices Association: https://www.actdental.com/bpaDownload ACT's BPA app on the Apple App Store: https://apps.apple.com/us/app/best-practices-association/id6738960360Download ACT's BPA app on the Google Play Store: https://play.google.com/store/apps/details?id=com.actdental.join&hl=en_USJoin ACT's To The Top Study Club: https://www.actdental.com/tttGet The Best Practices Magazine for free: https://www.actdental.com/magazinePlease leave us a review on the podcast: https://podcasts.apple.com/us/podcast/the-best-practices-show-with-kirk-behrendt/id1223838218Episode Resources:Watch the video version of Episode 983: https://www.youtube.com/@actdental/videosWatch Episode 954 with Shelley DeGroff: https://www.youtube.com/watch?v=ZjJ6cLq_k50Main Takeaways:Stay on top of your EOBs by auditing them regularly.Evaluate your master fee to ensure you're paid what you're owed.Learn what stacking order means and how it can affect your practice.Opt-outs are not automatic! Be proactive so they are processed correctly.You don't need to be 100% PPO or 100% fee-for-service. Have a healthy mix.Don't get complacent or comfortable. Understand the contracts you're agreeing to.Snippets:0:00 Introduction.1:16 Shelley's background.2:10 A refresher on important PPO changes.7:15 Audit your EOBs regularly.10:23 Master fee, explained.17:29 Stacking order, explained.20:55 How PPO...

We were inundated with new Windows features in 2025, but which ones actually moved the needle? Fortnite isn't just back on iPhone and Android, it's available on Windows 11 on Arm, and it works great! Plus, 2 big mobile wins for Epic Games and some thoughts on the "right" way to roll out AI features.Windows 11 Best Windows 11 updates of 2025, in no particular order... Dark mode improvements to File Explorer Widgets major overhaul with separate widgets and Discovery feed Xbox Full Screen experience - especially good on handhelds, of course, but also any PC you use for gaming with a controller Click to Do (Copilot+ PC only) External fingerprint reader support for Windows Hello ESS -External/USB webcams supported by Windows Studio Effects (Copilot+ PC only) Quick Machine Recovery is the tip of a wave of new foundational features like Admin Protection, Smart App Control (updates), and more that go beyond surface-level look and feel Redesigned Start menu isn't perfect but it's a nice improvement Copilot Vision, though this type of thing may make more sense on phones AI features in Paint, Photos, Notepad, and Snipping Tool Natural language interactions like the agent in Settings, file search, and more (mostly Copilot+ PC only, but you can do this in Copilot as well) Bluetooth LE support for improved audio quality in game chat, voice calls Gaming on Windows 11 on Arm and Snapdragon X: Major steps forward, but the same issue as always Looking ahead to 2026: 26H1, Agentic features that work, potential Windows 12, and AI PCs AI An extensive new interview with Mustafa Suleyman confirms why this guy is special and how confusing it is that Copilot is so disrespected Microsoft Copilot is auto-installing on LG smart TVs and there's no way to remove it GPT-5.2 is OpenAI's answer to Gemini 3 ChatGPT Images is OpenAI's answer to Nano Banana Pro Disney invests $1 billion OpenAI, sues Google Opera Neon is now generally available for $20 per month AI is moving quick as we all know but the bigger issue may be the incessant marketing about features like agents that don't even work now Microsoft is getting pushback on forced Copilot usage, price hikes Google is expanding its use of "experiments" outside of mainstream products with things like NotebookLM, Mixboard, CC, and much more. Maybe this is the better approach: Test separately and then integrate it into existing products Oddly enough, Microsoft does have a Windows AI Lab for this kind of experimentation Many small models vs. one big LLM in the cloud Mobile Fortnite is back in the Google Play Store in the U.S. as Google plays nice Apple loses its contempt appeal, the end of "junk fees" (Apple Tax) is in sight Xbox and gaming Xbox December Update has one big update for the mobile app and one big update for Xbox Wireless Headphones There's a new Xbox Developer Direct coming in January Half-Life 3 may really be happening, but it will be a Steam Machine launch title so it could be a while Tips & picks Tip of the year: De-enshittify Windows 11 App pick of the year: Fortnite RunAs Radio this week: Zero Trust in 2026 with Michele Bustamante Brown liquor pick of the week: Lark Symphony No. 1 These show notes have been truncated due to length. For the full show notes, visit https://twit.tv/shows/windows-weekly/episodes/963 Hosts: Leo Laporte, Paul Thurrott, and Richard Campbell Sponsors: auraframes.com/ink framer.com/design promo code WW outsystems.com/twit cachefly.com/twit

We were inundated with new Windows features in 2025, but which ones actually moved the needle? Fortnite isn't just back on iPhone and Android, it's available on Windows 11 on Arm, and it works great! Plus, 2 big mobile wins for Epic Games and some thoughts on the "right" way to roll out AI features.Windows 11 Best Windows 11 updates of 2025, in no particular order... Dark mode improvements to File Explorer Widgets major overhaul with separate widgets and Discovery feed Xbox Full Screen experience - especially good on handhelds, of course, but also any PC you use for gaming with a controller Click to Do (Copilot+ PC only) External fingerprint reader support for Windows Hello ESS -External/USB webcams supported by Windows Studio Effects (Copilot+ PC only) Quick Machine Recovery is the tip of a wave of new foundational features like Admin Protection, Smart App Control (updates), and more that go beyond surface-level look and feel Redesigned Start menu isn't perfect but it's a nice improvement Copilot Vision, though this type of thing may make more sense on phones AI features in Paint, Photos, Notepad, and Snipping Tool Natural language interactions like the agent in Settings, file search, and more (mostly Copilot+ PC only, but you can do this in Copilot as well) Bluetooth LE support for improved audio quality in game chat, voice calls Gaming on Windows 11 on Arm and Snapdragon X: Major steps forward, but the same issue as always Looking ahead to 2026: 26H1, Agentic features that work, potential Windows 12, and AI PCs AI An extensive new interview with Mustafa Suleyman confirms why this guy is special and how confusing it is that Copilot is so disrespected Microsoft Copilot is auto-installing on LG smart TVs and there's no way to remove it GPT-5.2 is OpenAI's answer to Gemini 3 ChatGPT Images is OpenAI's answer to Nano Banana Pro Disney invests $1 billion OpenAI, sues Google Opera Neon is now generally available for $20 per month AI is moving quick as we all know but the bigger issue may be the incessant marketing about features like agents that don't even work now Microsoft is getting pushback on forced Copilot usage, price hikes Google is expanding its use of "experiments" outside of mainstream products with things like NotebookLM, Mixboard, CC, and much more. Maybe this is the better approach: Test separately and then integrate it into existing products Oddly enough, Microsoft does have a Windows AI Lab for this kind of experimentation Many small models vs. one big LLM in the cloud Mobile Fortnite is back in the Google Play Store in the U.S. as Google plays nice Apple loses its contempt appeal, the end of "junk fees" (Apple Tax) is in sight Xbox and gaming Xbox December Update has one big update for the mobile app and one big update for Xbox Wireless Headphones There's a new Xbox Developer Direct coming in January Half-Life 3 may really be happening, but it will be a Steam Machine launch title so it could be a while Tips & picks Tip of the year: De-enshittify Windows 11 App pick of the year: Fortnite RunAs Radio this week: Zero Trust in 2026 with Michele Bustamante Brown liquor pick of the week: Lark Symphony No. 1 These show notes have been truncated due to length. For the full show notes, visit https://twit.tv/shows/windows-weekly/episodes/963 Hosts: Leo Laporte, Paul Thurrott, and Richard Campbell Sponsors: auraframes.com/ink framer.com/design promo code WW outsystems.com/twit cachefly.com/twit

El programa 2796 de Radiogeek, les habló de varios temas importantes. Apple actualiza sus sistemas a 26.2, desde iOS, WatchOS, macOS, etc y recomienda que actualicen por un tema de seguridad; ademas iRobot cae en banca rota; Fortnite disponible nuevamente luego de 5 años en Google Play Store; Samsung adelantaría el lanzamiento de sus smartphones A37 y A57, y por ultimo les adelanto los valores de los equipos Huawei en Argentina. Toda esta información la pueden encontrar desde nuestra web www.infosertec.com.ar o bien desde el canal de Telegram/Whastapp, o Instagram. Esperamos sus comentarios.

Thank you for joining us! To stay connected with us visit us here, on SoundCloud and on: Website: https://www.mynpmc.com/ Facebook: https://www.facebook.com/mynpmc YouTube: https://www.youtube.com/channel/UCnOiemCev_mHyZNgU2QgwnA Download the NPMC app on the: Google Play Store: https://play.google.com/store/apps/details?id=com.echurchapps.newparis&hl=en_US Apple App Store: https://apps.apple.com/us/app/new-paris-missionary-church/id1228753320 Give Online: https://pushpay.com/g/newparismissionarychurch New Paris Missionary Church is located in New Paris, Indiana. We would love for you to join us in person or online on Sundays as we worship God together. Our service begins at 10:00 a.m. We hope to see you soon!

Running a business is expensive — and a large portion goes to your team. In this episode, Kirk Behrendt brings back Miranda Beeson, ACT's director of education, to kick off a series on overhead with team compensation percentage. They break down what it is, how it impacts your practice, and what you can do to improve your numbers. To learn how to keep team compensation in a healthy range, listen to Episode 982 of The Best Practices Show!Learn More About Miranda:Send Miranda an email: miranda@actdental.com Follow Miranda on ACT's Instagram: https://www.instagram.com/actdentalSend Gina an email to learn more about ACT: gina@actdental.com More Helpful Links for a Better Practice & a Better Life:Subscribe to The Best Practices Show: https://the-best-practices-show.captivate.fm/listenJoin The Best Practices Association: https://www.actdental.com/bpaDownload ACT's BPA app on the Apple App Store: https://apps.apple.com/us/app/best-practices-association/id6738960360Download ACT's BPA app on the Google Play Store: https://play.google.com/store/apps/details?id=com.actdental.join&hl=en_USJoin ACT's To The Top Study Club: https://www.actdental.com/tttGet The Best Practices Magazine for free: https://www.actdental.com/magazinePlease leave us a review on the podcast: https://podcasts.apple.com/us/podcast/the-best-practices-show-with-kirk-behrendt/id1223838218Episode Resources:Watch the video version of Episode 982: https://www.youtube.com/@actdental/videosMain Takeaways:Think of team compensation as an investment, not an expense.Your team compensation percentage should be between 25% and 30%.If team compensation percentage is over 30%, you are too people-dependent.Define accountabilities, processes, and responsibilities to be systems-dependent.Consider profit-sharing models or hourly plus commission so your team can earn more.Snippets:0:00 Introduction.1:06 Team compensation percentage, explained.3:53 How this metric impacts the practice.10:16 What you can do to impact this metric.16:47 ACT's BPA.Miranda Beeson, MS, BSDH Bio:Miranda Beeson has over 25 years of clinical dental hygiene, front office, practice administration, and speaking experience. She is enthusiastic about communication and loves helping others find the power that words can bring to their patient interactions and practice dynamics. As a Lead Practice Coach, she is driven to create opportunities to find value in experiences and cultivate new...

I18 GK Podcast is back from Hiatus! 99WC Winner Saskia Webber and Comedian Michael Magid are joined by The TKI Podcast and Gloves OFF Crew to answer the age old question. Which school is GKU? Share your thoughts before PT2 Records. 64 Team Bracket avail online .  Great listen for young coaches, players and parents!! Download the Union GK community on Apple or Google Play Stores for more! Video Link Here - https://www.theunionsports.com/feeds/2491611 *If you want us to come to your town; all you've got to do is DM us @goalkeeperpodcast on The Union & tell us what you've got in mind. The Following is a FREE Preview of the popular Inside The 18 Goalkeeper Podcast. Want to continue watching or listening? Then Join a 30 day free trial of The Union GK App the new exclusive home of  the pod. For more info; go to www.theuniongk.com ; or download the The Union GK Community on Apple or Google Play Stores. Thanks for all your support & we'll see you on The Union! Unlock Excellence with UNION GK APP Premium Features: One-On-One Virtual Coaching Sessions: Meet with world-class coaches and goalkeepers to discuss your performance, technical assessments, the college recruiting process, and more. Personalized Training Plans: Access to tailored training plans designed by professional goalkeepers to enhance skills and understanding of the position. Exclusive Drills Library: Unlimited access to the Union GK's goalkeeping drills and exercises for players to fine-tune technical and tactical awareness. Pro Analysis Tools: Receive insightful feedback on past performance from expert coaches to elevate your game. Mindset and Performance Coaches: Access to coaches specializing in mental toughness in soccer players. Access to help to boost self-esteem, conflict resolution with coaches and players, and mindset. The Gift That Keeps Them in the Game! Your Premium Subscription to The Union Goalkeeper App offers easily accessible tools at the low yearly cost of $49.99 - Subscribe now for the year, and you'll receive an exclusive UNION GK premium hat (retail value $25.00)! Use code HOLIDAYGWP at checkout. Don't miss out – Keeperstop Coupon Code:  Union GK members can save an additional 10% with code:  UGK23.  Contact the goalkeeper equipment experts in the USA for goalkeeper gloves and equipment.  Always always available to answer any sizing or equipment question. Don't forget to sign up for office Hours on the Union GK App Portal https://www.theunionsports.com/office_schedulers?k=c1a46a8b Hosted by Simplecast, an AdsWizz company. See pcm.adswizz.com for information about our collection and use of personal data for advertising.

The sun has sadly set on FC Cincinnati for 2025. At least we can take pride in taking down our in-state rivals, but the cataclysmic wipeout against the eventual MLS Cup winners left fans searching for answers. What is it that we can glean from our 2025 squad, considering how much had to be fixed in the past offseason? Has the ship been steered toward a productive 2026, or are we still patching the leaks in the hull? We go on location to talk with stats insider Nate Gilman to crack the Orange & Blue's eggshell before we figure out to put them back together. Tune in and trade threads with us! #MLS #FCCincinnati #soccer Become a Patron! Subscribe to Cincinnati Soccer Talk Don't forget you can now download and subscribe to Cincinnati Soccer Talk on iTunes today! The podcast can also be found on Stitcher Smart Radio now. We're also available in the Google Play Store and NOW ON SPOTIFY! As always we'd love your feedback about our podcast! You can email the show at feedback@cincinnatisoccertalk.com. We'd love for you to join us on our Facebook page as well! Like us at Facebook.com/CincinnatiSoccerTalk.

Are you truly a great leader? Or are you overestimating how good you are? In this episode, Kirk Behrendt brings in Michelle Wakeman, one of ACT's amazing coaches, to reframe what it means to be a leader, why it's important, and to share some of the best leadership lessons from thriving practices. To learn how to lead with confidence to build a successful practice, listen to Episode 981 of The Best Practices Show!Learn More About Michelle:Send Michelle an email: michelle@actdental.com Follow Michelle on ACT's Instagram: https://www.instagram.com/actdentalSend Courtney an email to learn more about ACT: courtney@actdental.com Send Gina an email to learn more about ACT: gina@actdental.com More Helpful Links for a Better Practice & a Better Life:Subscribe to The Best Practices Show: https://the-best-practices-show.captivate.fm/listenJoin The Best Practices Association: https://www.actdental.com/bpaDownload ACT's BPA app on the Apple App Store: https://apps.apple.com/us/app/best-practices-association/id6738960360Download ACT's BPA app on the Google Play Store: https://play.google.com/store/apps/details?id=com.actdental.join&hl=en_USJoin ACT's To The Top Study Club: https://www.actdental.com/tttGet The Best Practices Magazine for free: https://www.actdental.com/magazinePlease leave us a review on the podcast: https://podcasts.apple.com/us/podcast/the-best-practices-show-with-kirk-behrendt/id1223838218Episode Resources:Watch the video version of Episode 981: https://www.youtube.com/@actdental/videosRead Traction by Gino Wickman: https://benbellabooks.com/shop/tractionMain Takeaways:Have a clear vision. Your vision is what provides direction for your team.Clearly define your clinical, financial, team culture, and life vision.Communicate your vision and core values to your team.Repeat your vision and core values for alignment.Walk the talk as the leader. Set the example.Snippets:0:00 Introduction.0:58 ACT/Smile Source and BPA.3:29 Why this is an important topic.4:50 How does this show up in your practice?10:22 Three key things that great leaders define.14:02 Vision provides direction.18:44 Four key areas of practice vision: Clinical vision.22:51 Four key areas of practice vision: Financial vision.26:13 Four key

A Chinese mainland spokesman on Wednesday condemned Taiwan's Democratic Progressive Party authorities for banning the mainland social media app RedNote, or Xiaohongshu, calling the move "an act against democracy" and driven by self-interest.中国大陆发言人周三谴责台湾民进党当局封禁大陆社交媒体应用“小红书”（RedNote），并称此举是“反民主行为”，受私利驱使。Chen Binhua, spokesman for the State Council Taiwan Affairs Office, said at a news conference that the DPP authorities' decision deprives people in Taiwan, especially young people, of their right to information and their freedom to use social media platforms.国务院台办发言人陈斌华在新闻发布会上表示，民进党当局的决定剥夺了台湾民众，尤其是年轻人的信息权和使用社交媒体平台的自由。The ban, announced on Dec 4, was imposed by Taiwan's "interior affairs department" for a year, citing alleged failures in "multiple cybersecurity indicators" and claims of "frequent fraud".该禁令于12月4日宣布，由台湾“内政部门”以所谓“多个网络安全指标不达标”和“频繁涉诈”为由，实施为期一年的封禁。Chen argued that RedNote allows people in Taiwan, especially young users, to learn about the mainland's real situation and interact positively with mainland netizens. This, he added, breaks through the "information cocoons" and long-standing slander about the mainland that the DPP authorities have deliberately cultivated.陈斌华指出，小红书让台湾民众，特别是年轻用户能够了解大陆真实情况，并与大陆网友积极互动，有助于打破民进党当局刻意营造的“信息茧房”和长期对大陆的抹黑叙事。"The DPP authorities claim they are 'combating fraud', but in reality they are acting 'against democracy'," he said, adding that the ban exposes their "inner fear and unease".他表示：“民进党当局声称在‘打击诈骗'，但实际上是在‘反民主'。”此举暴露了他们“内心的恐惧与不安”。Chen denounced the ban as a reckless action that tramples on democracy and restricts freedom. "It has also severely affected the livelihoods of those in Taiwan who rely on RedNote for income," he added.陈斌华谴责该禁令是践踏民主、限制自由的鲁莽行为，并补充说：“这也严重影响了依赖小红书谋生的台湾民众的生计。”According to reports, RedNote has more than 3 million users in Taiwan, 70 percent of whom were born after 1990. Following the announcement of the ban, downloads of the app surged, pushing RedNote to the top of Taiwan's social app download rankings on Sunday. The app is still available on both Google Play Store and Apple App Store, but it can only be used through a VPN.据报道，小红书在台湾拥有超过300万用户，其中70%为“90后”。禁令宣布后，应用下载量激增，使其在周日登上台湾社交类应用下载榜首。尽管小红书仍可在Google Play和苹果App Store下载，但只能通过VPN使用。Chen pointed to media reports showing that Facebook was involved in nearly 60,000 fraud cases last year and has already exceeded 30,000 cases this year, far more than the number attributed to RedNote by the DPP authorities.陈斌华引用媒体报道指出，Facebook去年涉诈近6万起，今年已超3万起，远高于民进党当局归因于小红书的数字。He further criticized the DPP authorities for opposing anything that Taiwan residents use and blocking anything popular among young people, from mainland-based shopping platforms and video sites to social media, saying the DPP has effectively become the "party of restricting people".他进一步批评民进党当局对台湾民众所用之物皆反对，对年轻人喜爱的热门应用皆加以封堵——从大陆购物平台、视频网站到社交媒体，称其事实上已成“限制人民的政党”。The ban has drawn widespread criticism across the island. Cheng Li-wun, chairwoman of the Chinese Kuomintang party, said the DPP's ban on RedNote is merely the first step toward building a "great firewall" under the guise of fighting fraud.该禁令在岛内引发广泛批评。中国国民党主席郑丽文表示，民进党以打诈为名封禁小红书，只是构建“防火长城”的第一步。She noted that the DPP authorities cannot tolerate the fact that on RedNote, users of different backgrounds can freely and amicably discuss topics ranging from beauty and fashion to everyday life.她指出，民进党当局无法容忍不同背景的用户在小红书上自由、友善地交流，从美妆、时尚到日常生活的各类话题。"The DPP authorities will inevitably face the consequences of their reckless actions," Chen said, adding that such regressive measures cannot stop the growing trend of people in Taiwan, especially young people, seeking to learn about and connect with their compatriots on the mainland.陈斌华表示：“民进党当局必将为其鲁莽行为承担后果。”他强调，这类倒退举措无法阻挡台湾民众，尤其是年轻人了解大陆、与大陆同胞交流的趋势。Condemn/kənˈdem/谴责self-interest/'self'intərist/私利information cocoon信息茧房regressive measures倒退举措

Dr. Alison Loren and Dr. Ann Partridge share the latest guideline from ASCO on the management of cancer during pregnancy. They highlight the importance of this multidisciplinary, evidence-based guideline and overarching principles for the management of cancer during pregnancy. Drs. Loren and Partridge discuss key recommendations from each section of the guideline, including diagnostic evaluation, oncologic management, obstetrical management, and psychological and social support. They also touch on the importance of this guideline and accompanying tools for clinicians and how this serves as a framework for pregnant patients with cancer. The conversation wraps up with a discussion on the unanswered questions and how future evidence will inform guideline updates.  Read the full guideline, "Management of Cancer During Pregnancy: ASCO Guideline" at www.asco.org/survivorship-guidelines TRANSCRIPT This guideline, clinical tools, and resources are available at www.asco.org/survivorship-guidelines. Read the full text of the guideline and review authors' disclosures of potential conflicts of interest in the Journal of Clinical Oncology, https://ascopubs.org/doi/10.1200/JCO-25-02115   Brittany Harvey: Hello and welcome to the ASCO Guidelines Podcast, one of ASCO's podcasts delivering timely information to keep you up to date on the latest changes, challenges, and advances in oncology. You can find all the shows, including this one, at asco.org/podcasts. My name is Brittany Harvey, and today I am interviewing Dr. Alison Loren from the Perelman School of Medicine of the University of Pennsylvania and Dr. Ann Partridge from Dana-Farber Cancer Institute, co-chairs on "Management of Cancer During Pregnancy: ASCO Guideline." Thank you for being here today, Dr. Loren and Dr. Partridge. Dr. Alison Loren: Thanks for having us. Dr. Ann Partridge: It's a pleasure. Brittany Harvey: And then just before we discuss this guideline, I would like to note that ASCO takes great care in the development of its guidelines and ensuring that the ASCO conflict of interest policy is followed for each guideline. The disclosures of potential conflicts of interest for the guideline panel, including Dr. Partridge and Dr. Loren who have joined us here today, are available online with the publication of the guideline in the Journal of Clinical Oncology, which is linked in the show notes. So then to dive into the meat of this guideline, to start us off, Dr. Loren, could you provide an overview of the scope and purpose of this new guideline on the optimal management of cancer during pregnancy? Dr. Alison Loren: Sure, thanks, Brittany. So this was really born out of I think a lot of passion and concern for this really vulnerable patient population. We have observed, and I am sure it is not any surprise to your audience, that the incidence of cancer in young people is increasing. And simultaneously, people are choosing to become pregnant at older ages, and so we are seeing more and more people with a cancer diagnosis during their pregnancy. And for probably obvious reasons, there is really no way to do randomized clinical trials in this population. And so really trying to assemble and articulate the best evidence for safely managing the diagnosis of cancer, the management of cancer once it is confirmed, being thoughtful about obviously the health of the mom, but also attending to potential risks to the developing fetus, and really just trying to be really comprehensive and balanced about all the choices for these patients when they are facing some really challenging decisions in a very emotionally fraught environment. And I think it is really emotionally fraught for the providers, too. You know, this is obviously an extremely intense, very emotional set of decisions, and so trying to provide a rudder essentially to sort of help people frame the questions and trying to make as evidence-based a set of recommendations as possible. Dr. Ann Partridge: And I would just add that "evidence-based" is a strong word here because typically our, as you just heard, our gold standard evidence is a randomized trial, but you can't do that in this setting, in general. And so, what we were able to do with the support of the phenomenal ASCO staff was to pull together kind of the world's literature on the safety and outcomes of treatments during pregnancy, as well as consensus opinion. And I think that is a really, really critical difference about this particular guideline compared to many of the other ones that ASCO does, where consensus and good judgment needed to kind of rule the day when evidence is not available. So, there is a lot of that in our recommendations. Dr. Alison Loren: That is such a good point. And I just, before we move forward, I just want to reflect that the composition of the panel was really broad and wide-ranging. We had maternal medicine specialists, we had legal and ethical experts, we had representatives who understand pharmaceutical industries' perspectives, and then medical oncologists representing the full spectrum of oncology diagnoses. And so it was a really diverse, in terms of expertise, panel, internationally composed to try to really get the best consensus that we could in the absence of gold standard evidence. Brittany Harvey: Absolutely. That multidisciplinary panel is really key to developing this guideline and, as you said, looking at the evidence and even though it does not reach the level of randomized trials, still critically evaluating it and reviewing that along with consensus to come up with optimal management for diagnosis and management of cancer during pregnancy. So then to follow that up, I would like to next review the key recommendations of the guideline across the main sections that the expert panel provided. First, I will throw this out to either of you, but what are the important general principles for the management of cancer during pregnancy? Dr. Ann Partridge: I think there were three major principles that we hammer home in the guidelines. One is that this is a team sport. It is multidisciplinary care that is necessary in order to optimize outcomes for the patient and potentially for the fetus. And that you really need to, from the beginning, bring in a coordinated team, including not just oncologists but obstetricians, maternal-fetal medicine specialists, neonatologists, ethics consultants, and obviously the patient and potentially her family. So that, I think, is one of the most important things. Second would be that obviously in a pregnancy, there are two potential patients and that the nuances of safety and risk from treatment is really wrapped up in where in the trimester of the pregnancy the patient is diagnosed, along with the kind of cancer that it is, both the urgency of treatment and the risk of the cancer, as well as the potential risks of any given intervention across the cancer continuum. It is a broad guideline in that regard. And then finally, and this is particularly timely given what is going on from a sociopolitical standpoint in the U.S., really thinking about informed consent and potential ethical as well as legal implications of some of the choices that patients might have when they are thinking about, in particular, continuing a pregnancy or potential termination. Dr. Alison Loren: And I will just add that I think that the key to all of this guidance is nuance and individualization and also making sure that patients and their care providers understand all the choices that are available to them and also the consequences of those choices. You know, nobody would choose to receive chemotherapy during pregnancy if that wasn't necessary. So there are risks to treatment, but there are also risks to not treatment. And making sure that in a suboptimal situation where you do not have a lot of evidence, trying to weigh, the best you can, the risks and benefits of all of the choices so that the patient can come to a decision about the treatment plan that is right for her. Brittany Harvey: Definitely. And those core concepts really set the stage for individualized care on what is necessary for appropriate multidisciplinary care, prioritizing both patient autonomy and informed decision making. With those core concepts and key principles in mind, I would like to move into the recommendations section of the guideline. So what are the key recommendations regarding diagnostic evaluation for pregnant patients with signs or symptoms of cancer? Dr. Alison Loren: I think the most important thing is to not delay, that there are very careful and well-thought-out recommendations for how to evaluate a potential cancer. And while there are certain things that we know can be harmful, particularly when certain dose thresholds are exceeded - for instance, abdominal imaging, there are certain radiographic thresholds that you don't want to exceed because of risk of harm to the embryo or fetus - there are still lots of options for diagnosing cancer during pregnancy. And again, thinking about the costs of not doing versus the cost of doing, right? It is really important to make the diagnosis of cancer if that is a consideration or a concern. And sometimes going directly to biopsies or getting definitive studies, even if there is a small risk to the developing fetus, is really essential because if the mom does not survive, of course, the fetus is also not going to survive. And so we need to be thinking first about the patient who is sitting in front of us, the woman who needs to know what is going on in her body so she can make good decisions about her health. So, I think that is a key principle in thinking about this. Brittany Harvey: Absolutely. So, following that diagnosis of a new or recurrent cancer, what is recommended for oncologic management of patients who are diagnosed with cancer during their pregnancy? Dr. Ann Partridge: So, I think the general principle is, again, cancer is such a wide number of diseases and even within diseases, a range of stages and risks and associated opportunities for risk reduction and/or treatment depending on the type of cancer. Just by example, in the work that I do, which is breast cancer, once someone has had a surgery in the early-stage setting, a lot of our treatment is about risk reduction. And that is very different than from what Alison does, which is treating people with leukemia, where it is kind of binary. If you do not treat, including with cytotoxic drugs, the patient and an unborn fetus will die, especially early in the pregnancy, obviously. So this is where cancers are very, very different. So I think taking the approach of what would you do if the patient were not pregnant? And what is the best treatment for that particular patient with that particular kind of cancer? And then applying the pregnancy and where the patient is in that pregnancy in terms of the trimester of the pregnancy, and what is safe and what is unsafe from the options that you would give her if she were not pregnant. And then if the patient is choosing to keep the pregnancy, which in my practice, many people come and they come to me because they want to hold onto their pregnancy and want to figure out how to make it work, coming up with a regimen that tries to give them kind of the best bang for the buck, the best possible breast cancer therapy with the least harm, when possible, to the fetus. It is a bit of a balance, right? And then we cannot always give people the best approach. And sometimes it comes down to making a decision to give up something that may improve their survival so as not to harm the fetus. And sometimes it goes the opposite direction where a patient will say, "Oh, that is going to improve my survival by 5% and you can't give it to me now? I am going to choose to terminate." Even though that is obviously a very, very difficult and challenging decision to make in this setting because they want to optimize their survival and ideally live on to potentially have another pregnancy in the future if that is something that is of interest to her. So these are really, really hard conversations as you can imagine, but that is kind of where we go. Dr. Alison Loren: Yeah, and I think this is where the need for more research and understanding is really key because sometimes questions come up. I guess I am thinking about like HER2-directed agents, which we know are contraindicated in pregnancy. But what about sequencing? Does it matter when you get it? Can you get it later? I think that is something that we don't really fully understand. And similarly, again, this is obviously like a breast cancer and blood cancer focused discussion because that is what we do, but thinking about managing blood cancers, certainly with acute lymphoblastic leukemia, there is actually a lot of options now that, you know, you could potentially use to temporize or sort of get somebody through a pregnancy relatively safely. I am focusing on the word "relatively" because we do not know what the long-term impact might be of potentially not optimal therapy in the long run. And then thinking about other things like timing of a bone marrow transplant relative to either delivery or termination. I mean, again, we really do not know what are the right sets of sort of timing considerations for those. So there are just a lot of unknowns. And I think trying to be sort of self-aware and humble and honest about those unknowns so that the patient can engage in the conversation in a way that is meaningful to her and make the decisions that make the most sense for her. I think the most important thing is to make sure that the patient feels supported and safe to make those decisions with as little regret as possible. Brittany Harvey: Yes, I think it is really important that you mentioned that there is a wide range of cancers here, and that means that care really needs to be individualized for each patient. I will also note, just in this section, that I found really informative while reading through the guideline the list of oncologic agents that may be offered in each individual trimester, whether it is contraindicated or it can be used with caution, or if there is relatively good safety data on it for prioritizing maternal treatment needs and balancing fetal safety at the same time. I think that is, that is really key. And I think readers will really like that section of the guideline to provide concrete information for them and their patients. Dr. Alison Loren: Thank you. We actually spent a lot of time on that table and just thinking about what it should look like, what the format ought to be, what the language ought to be. Because of course, at the end of the day, everything should be used with caution. So what does that actually mean? And we sort of tried to explicate that a little bit in like the footnotes. We really tried to leverage what we know from clinical experience, from package labels, from mechanism of action to try to be as clear and definitive as we could be without overstating or understating what we know. Dr. Ann Partridge: Yeah, and I think we are focusing on breast and leukemia because that is what we do. But the truth is much of the data comes from those two areas. Leukemia, not because it is so common, but because you do not really have choices to treat or not treat. And so for decades, they have been treating and saying, "We hope the progeny comes out okay." And for many agents it does. The babies are okay. And so, we have reasonable observational data. And then in breast cancer, there have been actually some prospective registry-type studies where people have been followed and treated when pregnant, and the progeny have been accounted for, and so we have some good experience in that way too. Again, not randomized trials, but at least data that suggests certain agents are safe. And increasingly, because of that, when we have had to treat patients, we have said, "Okay, let us do it on this registry so that we can at least learn from every patient that comes in in this situation." And so, I think we will have more and more data given the growing number of young adults with cancer and the delays in childbearing that are happening around the world, and particularly in Westernized countries. I wish we did not. We wish we did not see this problem, but of course, when we do, we have to make sure that we learn from it and try and get patients enrolled in these registries and any kinds of studies that are available. Dr. Alison Loren: Yeah, I will just underscore that to say that, you know, there is outcomes of pregnancy and then there is outcomes of pregnancy, right? So there is like, "Okay, the baby was born with 10 fingers and 10 toes, and they passed their Apgar, and they are doing all their developmental processes along the way." But what happens when they are 10 or 15 or 20? Are they maturing normally? Are they cognitively intact? And then, of course, it is really inseparable from what is the impact on a family of having the mom with cancer? And how does that impact childhood development and intellectual development? And so these are really, really important questions that are very difficult to answer given the longitudinal information that you need, but it is a really critical question that, you know, patients ask and we do not know the answer. Dr. Ann Partridge: Yeah, that actually leads me to one of the important principles in the guideline that is a little bit of a change from when I first started practicing, which is we have learned from the wider neonatology literature, as they have followed up on the children that were born prematurely, that it is actually better not to be premature and to keep the baby in utero as long as it is safe for the fetus and the mother as long as possible, ideally to term rather than delivering early and then giving the chemo after that or separating the chemo from before and after. We used to try and deliver early and then give agents, but now we typically will give agents that are safe to be given at the end of pregnancy, ideally close to term, a couple weeks out, to allow for the ability of count recovery, and you do not want to go into preterm labor with chemotherapy on board, but we used to go much earlier and have an argument with our maternal-fetal medicine doctors. "How early can you get them out?" And they would say, "How long can they stay in?" And increasingly, we have been able to try and compromise to go even later and allow the fetus to go to term because of the neonatal outcomes that in longer term there is a suggestion that the children are developing better in the long run if they are kept in utero for as long as possible. Dr. Alison Loren: Yeah, that is such a great point. I think that is probably the most important thing for people to take away. For anyone who sort of does this, I mean, no one does this regularly because it is a rare event, although I think it is increasing as I mentioned. But this idea that the third trimester is, most of us know, is primarily a time for growth. Most of the critical development has already occurred, and so administering most chemotherapy agents towards the end of the third trimester seems to be preferable long term than delivering them early. So that is a really big change. I think we used to try to sort of, "Oh, get them to 30 or 32 weeks and then deliver," but we really are trying to get them closer to term, 37 weeks or more, and then coordinating the treatment so that they are not nadiring, as Ann said, at the time of planned delivery. Brittany Harvey: Yes, and that is a really important point related to evidence-based care and why we have changed that practice. And so then that actually leads nicely into my next question. But as you both mentioned, this is an important collaboration between oncologists and obstetricians. So the next section of the guideline addresses obstetrical practice. And so beyond what is standard, what additional recommendations are there in obstetrical management for pregnant patients with cancer? Dr. Alison Loren: That is a great question. So I will say we were really struggling with like how much do we cover? Like this is an oncology guideline. We are not obstetricians. We certainly had great representation from our maternal-fetal medicine colleagues on the panel. But really trying to sort of give useful information without overstepping. And so I think that the main recommendations are to increase the frequency of fetal monitoring, make sure that there is close attention to blood counts in the patient. But I think there is really still a gap in terms of what we know about optimal management of a pregnant person who is receiving therapy and how to handle the pregnancy itself. The delivery should be a usual delivery. Our colleagues did not recommend a planned C-section. They recommended usual care in terms of planning for the delivery. Obviously, if a C-section is indicated, then it should be done, but it should not be planned this way because of the cancer diagnosis. And I guess the other thing that we mentioned in the guideline, although we were reluctant to push it too hard because of access to these specialized services, was evaluating the placenta after birth to ensure that there were no metastases in the placenta itself. Dr. Ann Partridge: Those are the main things, and judicious and prudent obstetrical care, as I think, you know, is trying to be practiced regularly with MFM. Typically these patients should be followed not by your average OB/GYN, but a maternal-fetal medicine specialist because these patients will have special concerns, especially if they are sick. So oftentimes, especially Alison's patients, are actually sick with leukemia. And so you are monitoring them a lot, whereas, you know, a breast cancer patient typically isn't sick, although they could get sick with their chemotherapy. And so we really want to hand-in-hand manage these patients with our MFM colleagues. Dr. Alison Loren: I think we also highlighted in the guideline just for the refresher purposes of the oncology community, generally which drugs that would be given in a normal oncology setting are safe to be given to a pregnant person. So we talked a little bit about what kinds of steroids are recommended, antiemetics, DVT prophylaxis, peripartum. These are things that we think about a lot in oncology, but just want to make sure that it sort of intersected appropriately with the care of a pregnant patient. Brittany Harvey: Definitely. That specialized care is really important for patients who are pregnant and have cancer. And then the last section of the recommendations addresses psychological and social support. As you both mentioned before, this is a highly emotional time and it can be difficult and challenging to make decisions. So what is recommended for the psychological and social support of pregnant patients with cancer? Dr. Ann Partridge: Well, as I said, it is really something that needs to be considered at the beginning, through the diagnostic period, all the way into survivorship. Ironically, even though it is a highly fraught, emotional situation, I find that my pregnant patients actually are extraordinarily resilient, and what they are really focused on often is the safety of the fetus, because again, many of the people that come to me, it is a highly wanted pregnancy. They are also focused on their own health, of course, and often you need to bring in social work, sometimes a psychologist, professionals who are there just to help manage their emotions while we are focusing on what do they need medically to be as healthy as possible, both for the again, the mother, the patient, and the fetus. It is very tricky, and I will say also bringing in sometimes people on the ethics team in the hospital to help, both from the "Are you recommending and giving something that is safe?" That is number one. And then number two, sometimes patients want to be treated with drugs that we do not have any safety data for in pregnancy. What are our obligations? I think most of us would say we would not treat someone if we do not have safety data and there is suspicion for concern. But where is that line in terms of the right thing to do by that patient? And so we are all beholden to our ethics colleagues to help us when we make decisions like that. You know, we all want to do right by the patient, but we have to uphold our oaths and legal obligations. I don't know if you have to add on that because it's very tricky. Dr. Alison Loren: It is, it is very hard. I mean, I think, you know, there is a lot of emotion, obviously any cancer diagnosis is extremely charged and people are already at sort of a heightened, you know, they are anticipating a new baby and planning around that. And so it is just an extremely disruptive is the smallest word I can think of to describe it. And I think that often there is a co-parent, there might be parents and in-laws and other siblings, and then there is care after delivery. And so it is just a very complex set of dynamics. And having both our ethics colleagues and our psychology and social work colleagues to sort of just pitch in and make sure that the patient is being supported. I think there are sometimes really difficult situations where maybe what the patient wants is different from what the father of the baby wants or what the rest of the family wants. And so that can be really challenging. And you never really know where those landmines are going to pop up. So it is good to have the team on board early and often. Dr. Ann Partridge: Yeah, I would add to that, the other thing here that I think is really important, like in all of medicine but especially in situations like this, this is where we have to be very careful as professionals not to impose our own ethical, moral, emotional, personal views on the patient and to try to reserve judgment as much as possible. We are their navigator with the most important evidence and information that we can provide in the current situation. And that is where this guideline is extraordinarily helpful, we hope, for clinicians in the years to come. And at the same time, we cannot necessarily impose our own views and what we would do on a patient or what we tell our daughters, sisters, friends, family members. It is very tricky in that way. And so sometimes not just support for the patient, but support for the care team may be warranted in some of these very fraught situations. Dr. Alison Loren: Yeah, that is such a great point. And I was sort of thinking that too. I mean, it is, of course, the patient is front and center, but these are really difficult situations to navigate. And I will just add also that a lot of times these patients end up in academic centers, which I think is that's where the expertise or even just the experience may be. But the downside of that is that, you know, the teams are constantly changing. You have a new resident, you have a new intern, you have a new attending, a new fellow. And so, you know, the patients may be subjected to lots of different ways of communicating and sometimes those perceived differences can be really challenging. So sort of team huddles to sort of make sure that everybody is reading from the same script and everyone is comfortable with how the information is being presented so that the patient does not feel more confused or more overwhelmed, that they are kind of getting a consistent message from the whole team that, "This is what we know, this is what we are recommending, here are your other choices, and here are the pros and cons of each of these options." Brittany Harvey: Yes, I think you have both touched on this and that bringing in appropriate experts to support both clinicians and patients and their decision-making and their mental health is really important for this section of the guideline. We have already discussed this a fair bit throughout our conversation, but in your view, what is the importance of this guideline and how will it impact both clinicians and pregnant patients diagnosed with cancer? Dr. Ann Partridge: I could start with that. We just talked about experts and having them all around, but the fact is most people do not have the experts all around when they are dealing with this. And I think this is, you know, an expert-based, evidence-based guideline where having this in one's back pocket, whether you are in rural Montana or at a major cancer center on either coast, you will be armed with the latest and the greatest in terms of what we know and what we do not know, and some very helpful algorithms for how to think through the process of dealing with a patient who is diagnosed during pregnancy, whichever type of cancer it is. We could not cover every single specific thing about every cancer, although it is a pretty long guideline and there is a lot of nuance in there. So you might find a lot about specific cancers. And I think that that will be very, very helpful for people who are faced with this situation in the clinics just to frame it out, think through. Sometimes there is no answer that is the perfect answer and then, you know, using this as kind of a scaffolding and phoning a friend who may have more experience to help guide you and guide the patient, most importantly. I think it will be very helpful in that regard. Dr. Alison Loren: Yeah, I think so too. And I have talked about that we are working on this guideline and the anecdotal feedback has been, "This is so helpful." Like there really has not been, I think, an all-in-one place, diagnostic considerations, radiographic considerations, staging, treatment, all the modalities, surgical, radiation, systemic chemotherapy. We tried to include, when we could, novel agents including targeted agents and monoclonal antibodies and bispecifics and cellular immunotherapies and non-cellular immunotherapies. We really, really tried to cover in 2025 what are people using to treat cancer and to try to give the most balanced view of what we think is is safe or reasonably safe and what we think is either unproven or known to be risky, really to have it be kind of a go-to, like all-in-one, as much information as we have about these really challenging cases. We tried to include, Ann mentioned, you know, specific cancers, and I think when there were specific things to shout out with specific cancers, we really tried to highlight that. Like, "Okay, lots of young patients with cancer have Hodgkin's lymphoma, so what is safe and what is not for that specific case?" Or, "What is safe or what is not when you are thinking about colon cancers?" And we have a shout-out in here about considering checking for DPD deficiencies in patients who are pregnant. And I know it is generally recommended nowadays, but certainly for people who are pregnant, you know, you really want to avoid excess toxicity. So I think just really trying to be attentive to specifics about certain cancers in young patients and what would be valuable for a practicing oncologist and obstetrician to know when you are faced with this situation. Dr. Ann Partridge: Yeah, and I think the other critical thing that is great about this guideline is it's a starting place. And I anticipate that we will be building on this guideline for many years to come. And remember that when first, I was not around then, but probably three or four decades ago, when chemotherapy was just coming out and patients were coming in pregnant, there was a feeling I am sure that was, "We cannot give this to this person because it is purposefully going to destroy cells. And when you destroy cells in a growing fetus, you are going to destroy or harm that fetus." And yet, people did not have great choices. It was get treated or die, especially with things like leukemia early on. And bold patients along with their oncologist said, "Bring it on." And that is how some of this literature has been born. And so moving forward, there will be either purposeful exposures or inadvertent exposures of some of our therapies where we will learn ultimately. And this is a place where we can update these guidelines. That is the beautiful thing about the ASCO guidelines is that they are constantly being thought about to be updated. And then when there is enough of a change in practice, they will be updated such that they will continue to inform how we do this in the years to come for patients who come in pregnant. Dr. Allison Loren: Yeah, and I will say I have been doing this long enough now, we were just talking about a different guideline, the fertility guideline earlier today, and over the 20 years that the fertility guidelines have been out, just the amount of research has really skyrocketed. And you can see as you look at each guideline how much we have learned, what we can say, "Yes, this is working," "No, this is not working." Like, it is stuff that we used to say, "Oh, we do not really know," and now we have answers.  I think I speak for both of us when I say that we are hopeful that this will serve as, as Ann said, as a starting off point and really inspire people to ask the questions and do the research so that we can give better guidance moving forward, really trying to think about, you know, mechanisms and leaning on our colleagues in pharma and in the government who sort of think about safety and efficacy, to sort of make sure that they are contemplating not just non-pregnant patients, but also pregnant patients or as they are thinking about marking the package inserts with safety guidelines around this. Brittany Harvey: Yes, this is a critically important first guideline on the management of cancer during pregnancy, and we will look forward to continuing to build on that. I think as you mentioned, this guideline is far-reaching and has a lot of recommendations in it. And so both the full text of the guideline and those at-a-glance algorithms, figures, and tables will be really useful for clinicians in their clinic. Finally, to wrap us up, we have just been discussing this a little bit, but specifically, what are the outstanding questions on the management of pregnant patients with cancer, and where is this further research needed? Dr. Alison Loren: There are lots and lots and lots of unanswered questions. And I think if you look at the table, most of what we say is, "We are pretty sure this is okay, we are not so sure about this." I am paraphrasing, but we really just are operating in a paucity of what we would normally consider gold-standard evidence. It is hard to imagine, of course, there would ever be, as we mentioned in the beginning, randomized trials. But I think that preclinical data, mechanistic data, trying to think about including as we go through animal data, making sure that we are looking at female animals and pregnant animals so that we can sort of fully understand what the impact may be. And then I think thinking about more localized therapies around sort of radiation, you know, we are now moving into really hyper-focused radiation treatments like protons. Is that better because there is less scatter? Like I think those are real considerations that we just do not know the answer to. What do you think? Dr. Ann Partridge: I think so many unanswered questions, and this is a call to action to continue to and increase the documentation of the experiences and outcomes for patients diagnosed during pregnancy. Dr. Alison Loren: Yeah, and I think the long-term outcomes too are really going to be critical. Brittany Harvey: Yes, we will look forward to learning about more evidence across the spectrum of care to inform future updates to this guideline. So I want to thank you both so much for your work to develop this guideline, to review the extensive amounts of literature that you did, and work to create this guideline. And thank you also for your time today, Dr. Loren and Dr. Partridge. Dr. Alison Loren: Thanks. It was fun. Dr. Ann Partridge: Yeah, thank you. Brittany Harvey: And finally, thank you to all of our listeners for tuning into the ASCO Guidelines Podcast. To read the full guideline, go to www.asco.org/survivorship-guidelines. You can also find many of our guidelines and interactive resources in the free ASCO Guidelines app, which is available in the Apple App Store or the Google Play Store. If you have enjoyed what you have heard today, please rate and review the podcast and be sure to subscribe so you never miss an episode. The purpose of this podcast is to educate and to inform. This is not a substitute for professional medical care and is not intended for use in the diagnosis or treatment of individual conditions. Guests on this podcast express their own opinions, experience, and conclusions. Guest statements on the podcast do not express the opinions of ASCO. The mention of any product, service, organization, activity, or therapy should not be construed as an ASCO endorsement. 

This week, Marianna sits down with Dr. Tai Hunte-Ceasar, Chief Medical Officer at the Department of Health in the U.S. Virgin Islands, to talk about the use of AI chatbots in the HIV community. Tune in to learn how they can assist in linkage to care and what it means for the HIV workforce. -- Resources mentioned in this episode: https://jomprep.com/https://healthenews.mcgill.ca/marvin-the-first-ai-powered-hiv-care-chatbot/https://www.aimeesays.com/en/homehttps://www.mambaonline.com/2024/11/18/chemsex-harm-reduction-ai-chatbot-aims-to-tackle-stigma-and-improve-health/https://www.chattopat.com/--Help us track the number of listeners our episode gets by filling out this brief form! (https://www.e2NECA.org/?r=AQX7941)--Want to chat? Email us at podcast@necaaetc.org with comments or ideas for new episodes. --Check out our free online courses: www.necaaetc.org/rise-courses--Download our HIV mobile apps:Google Play Store: https://play.google.com/store/apps/developer?id=John+Faragon&hl=en_US&gl=USApple App Store: https://apps.apple.com/us/developer/virologyed-consultants-llc/id1216837691

Dentists aren't just clinicians — they're also leaders and entrepreneurs! In this episode, Kirk Behrendt brings back Miranda Beeson, ACT's director of education, to share how to balance these three circles so you can gain control of your practice and reclaim your life. To start enjoying life in 2026 and beyond, listen to Episode 980 of The Best Practices Show!Learn More About Miranda:Send Miranda an email: miranda@actdental.com Follow Miranda on ACT's Instagram: https://www.instagram.com/actdentalSend Gina an email to learn more about ACT: gina@actdental.com More Helpful Links for a Better Practice & a Better Life:Subscribe to The Best Practices Show: https://the-best-practices-show.captivate.fm/listenJoin The Best Practices Association: https://www.actdental.com/bpaDownload ACT's BPA app on the Apple App Store: https://apps.apple.com/us/app/best-practices-association/id6738960360Download ACT's BPA app on the Google Play Store: https://play.google.com/store/apps/details?id=com.actdental.join&hl=en_USJoin ACT's To The Top Study Club: https://www.actdental.com/tttGet The Best Practices Magazine for free: https://www.actdental.com/magazinePlease leave us a review on the podcast: https://podcasts.apple.com/us/podcast/the-best-practices-show-with-kirk-behrendt/id1223838218Episode Resources:Watch the video version of Episode 980: https://www.youtube.com/@actdental/videosRegister to ACT's BPA for their Dental Practice Success Triad tool: https://join.actdental.com/users/sign_in?post_login_redirect=https%3A%2F%2Fjoin.actdental.com%2Fc%2Fpractice-coaching-tools%2Fdental-practice-success-triad#emailRead The E-Myth by Michael E. Gerber: https://www.michaelegerbercompanies.com/product/the-e-myth-revisitedLearn more about The Sletten Group: https://theslettengroup.comMain Takeaways:As a practice owner, you need to balance being a clinician, leader, and entrepreneur.Don't just “live in the chair”. If you neglect the other two circles, you can't thrive.Your practice will only grow to the level of your least developed circle.Anyone can improve their leadership and...

This week, WTJU is holding their Classical Marathon which means that there will be no radio version of Charlottesville Community Engagement. Yet, the production of the newsletter often depends on harvesting audio recordings of meetings. I'm Sean Tubbs, publisher and president of Town Crier Productions, and I've been chopping up sound into stories for over thirty years now. This podcast version for December 10, 2025 includes three sonic articles from the past week so I can make room for the next set.There will be another regular newsletter later on this evening.Here are the highlights:* Former Congressman Tom Perriello enters the race for the Democratic nomination to represent Virginia's Fifth District in the U.S. House of Representatives (read the story)* Two special elections scheduled in Virginia on January 6 (read the story)* Virginia transportation panel briefed on $20 million for Boulders Road project (read the story)* Albemarle Schools seek funding for fourth high school while Supervisors want more data on need (read the story)Charlottesville Community Engagement is a reader-supported publication. To receive new posts and support my work, consider becoming a free or paid subscriber.Today's only shout-out: Enjoy the WTJU Classical Marathon through the new app!WTJU is pleased to announce our brand new mobile app! You can download a version from either the Apple App Store or Google Play Store. Here are the links to both:* iPhone version* Android versionThe WTJU app is the place to tune in and listen live to WTJU, WXTJ, and Charlottesville Classical. Aside from the live stream, listen to archived shows, view recent songs, playlists, and program schedules, check out videos of live performances, stay up-to-date on WTJU's most recent news and articles, and more!Live chat with your favorite hosts, share stories with your friends, and tune into your community all in the palm of your hand. This is a public episode. If you'd like to discuss this with other subscribers or get access to bonus episodes, visit communityengagement.substack.com/subscribe

We caught up with Declan Watters to learn more about his innovative and powerful tech for good medical app that he has developed. Declan Watters, MediSnap Who are we talking to, is it a logical journey to what you do now? I'm Declan Watters, a practicing paramedic and co-founder of MediSnap. The journey makes complete sense when you look back, though I didn't plan it this way. I started in pharmacy at age 14, working under Jim McCormick at Magees Pharmacy in Letterkenny. Spent 22 years in pharmaceutical retail, progressing through Cara Pharmacy Group, learning everything about medications - from otc, brand, generic and trade along with dispensing and wholesale operations. Then I moved into paramedicine about six years ago, completing my BSc (Hons) in Paramedic Science from UCC this year. I also have a BSc in Computer Science from LYIT back in 2005, which I honestly thought I'd never use professionally. Turns out, having pharmacy knowledge, emergency medicine experience, and computing skills is the exact combination needed to build MediSnap. The platform exists because I live this problem daily. When you meet someone in an emergency situation and they can't tell you what medications they're on - unconscious patients, confused elderly people, language barriers, flustered family members- you're making critical decisions with incomplete information. we built the tool I needed without actually knowing what we had. What are you currently working on? MediSnap - an AI-powered medication identification platform for healthcare professionals. You photograph medication packaging, prescriptions,bottle, handwritten or blister packs, and within 3-5 seconds you get instant identification plus critical drug interaction alerts. Rapidly painting a picture and allowing the medical professional to move ahead with treatment and cuts minutes googling medications, we cant know them all! We've just launched on Google Play Store, with iOS coming shortly. The platform supports multiple languages - English, Irish, Ukrainian, Polish, Portuguese, and Spanish - because language barriers are a massive issue in emergency healthcare. Especially the Cyrillic alphabet recognition, it read Ukrainian language and packaging. Right now we are managing rapid growth whilst preparing for regulatory approval through HPRA (Health Products Regulatory Authority). We've gone from company registration in October to 352 registered healthcare professionals using it operationally in emergency situations. We've had nearly 100,000 website hits and over 3,500 people checking out the platform. That's all organic growth - healthcare workers telling their colleagues about it. We dont have marketing or a budget. I'm also in conversations with Enterprise Ireland for seed funding, and we've got national media coverage coming. It's been a whirlwind few weeks. How long did it take you to build up the app, and how has it evolved over time? From company registration to live product took about six weeks. We launched the beta in late October 2025, and we've just gone commercial on Android. It was built on a shoestring budget whilst working full-time as a paramedic - evenings, nights, weekends. But we have been developing this this for the best part of 2025. I should mention - I have a silent partner, my Co-Founder and CTO, who handles all the technical development. We've been best mates since childhood, so working together just clicks. A lot of the best decisions happen over a pint or on the phone late at night, talking through problems. He prefers to stay out of the spotlight, but I couldn't have built this without him. Having someone you trust completely makes the hard days manageable. We compiled the proprietary medication database using my 22 years of pharmaceutical knowledge, designed the clinical workflows based on what I actually need in the field, and handled all the testing with colleagues. My co-founder built the platform architecture and makes sure everything actually works tech...

For the month of December, we look back at some favorite episodes of 2025. In this episode, Kirk Behrendt brings back Dr. Barrett Straub, ACT's CEO, to break down the one basic equation you need to know to produce more while working less. Stop spending 220 days at the office! To learn how to produce more the right way, listen to Episode 979 of The Best Practices Show!Learn More About Dr. Straub:Send Dr. Straub an email: barrett@actdental.com Join Dr. Straub on Facebook: https://www.facebook.com/barrett.d.straubSend Courtney an email to learn more about ACT: courtney@actdental.com Send Gina an email to learn more about ACT: gina@actdental.com More Helpful Links for a Better Practice & a Better Life:Subscribe to The Best Practices Show: https://the-best-practices-show.captivate.fm/listenJoin The Best Practices Association: https://www.actdental.com/bpaDownload ACT's BPA app on the Apple App Store: https://apps.apple.com/us/app/best-practices-association/id6738960360Download ACT's BPA app on the Google Play Store: https://play.google.com/store/apps/details?id=com.actdental.join&hl=en_USJoin ACT's To The Top Study Club: https://www.actdental.com/tttGet The Best Practices Magazine for free: https://www.actdental.com/magazinePlease leave us a review on the podcast: https://podcasts.apple.com/us/podcast/the-best-practices-show-with-kirk-behrendt/id1223838218Episode Resources:Watch the video version of Episode 979: https://www.youtube.com/@actdental/videosMain Takeaways:There are two ways to produce more: work more days or produce more per day.Figure out your production per day and gross production target for the year.Set your goals and decisions based on data, not with your emotions.Just working more days is not the answer. You need a plan.Snippets:0:00 Introduction.1:37 Why this is an important topic.2:48 Why emotion comes into this equation.3:49 The equation for gross production.7:06 Two key numbers to pull.12:35 Time is the new rich.14:21 Final thoughts.16:47 ACT's BPA.Dr. Barrett Straub Bio:Dr. Barrett Straub practices general and sedation dentistry in Port Washington, Wisconsin. He has worked hard to develop his practice into a top-performing, fee-for-service practice that focuses on improving the lives of patients through dentistry.A graduate of Marquette Dental School, Dr. Straub's...

Accessing mental health care can be a challenge. Outside the U.S., that challenge can at times be insurmountable. FSBP offers a program to help members around the world access counselors and other support to meet their behavioral, mental, and emotional health needs. Lyra Health is available to FSBP members outside the U.S. for counseling at no cost. Today, Karen Munson joins us to discuss this program and how members can access it. Visit https://fsbp.lyrahealth.com/ to register and begin accessing care. FSBP members can also call +44 33 00 241 021 for immediate assistance. You can download the Lyra Health app through the App Store or the Google Play Store. If you receive a request to enter the organization sponsoring your access to Lyra, please enter "FSBP". For more information on our various programs, please visit our video library at www.youtube.com/afspacares. Join us for future events at www.afspa.org/events.

Healthcare isn't broken — it's rigged against wellness and patient care! In this episode, Kirk Behrendt brings in Dr. Bryan Laskin, author of Unfair Care, to share his “why” behind this book and his mission to empower patients to get the best care possible in dentistry and medicine. To learn how you and your patients can make healthcare work better for you, listen to Episode 978 of The Best Practices Show!Learn More About Dr. Laskin:Join Dr. Laskin on Facebook: https://www.facebook.com/DrBryanLaskinFollow Dr. Laskin on Instagram: https://www.instagram.com/drbryanlaskinLearn more on Dr. Laskin's website: https://bryanlaskin.comLearn more about Toothapps and Cair: https://www.toothapps.comMore Helpful Links for a Better Practice & a Better Life:Subscribe to The Best Practices Show: https://the-best-practices-show.captivate.fm/listenJoin The Best Practices Association: https://www.actdental.com/bpaDownload ACT's BPA app on the Apple App Store: https://apps.apple.com/us/app/best-practices-association/id6738960360Download ACT's BPA app on the Google Play Store: https://play.google.com/store/apps/details?id=com.actdental.join&hl=en_USJoin ACT's To The Top Study Club: https://www.actdental.com/tttGet The Best Practices Magazine for free: https://www.actdental.com/magazinePlease leave us a review on the podcast: https://podcasts.apple.com/us/podcast/the-best-practices-show-with-kirk-behrendt/id1223838218Episode Resources:Watch the video version of Episode 978: https://www.youtube.com/@actdental/videosRead The Patient First Manifesto by Dr. Bryan Laskin: https://www.amazon.com/Patient-First-Manifesto-Practice-Dreams/dp/1736643711Read Dental Disorder by Dr. Bryan Laskin: https://www.amazon.com/Dental-Disorder-Bryan-Laskin/dp/1736643762Read Unfair Care by Dr. Bryan Laskin: https://www.amazon.com/Unfair-Care-Healthcare-Deserve-Designed/dp/1736643789Learn more about Smile Source Exchange: https://smilesource.com/exchangeMain...

1995 had hundreds of movies released that year. You already have heard Geek Salad cover the top 15 domestic box office winners of the year, but that only covers a small portion of the movies released. So now, the gang is back to cover some of the other more memorable movies from 1995, be they memorable for good reasons, or for not so good reasons. Andy and Mike are once again joined by Em from the Verbal Diorama Podcast (listen wherever you get your podcasts) and Kurt Smith (check out his reviews on Letterboxd) as they cover both the best picture nominees from that year, as well as some of their personal favorites. They go over some of the real fun ones, but also some of the ones that might not be great, but still stand out for some reason or another. Geek Salad is available at www.geeksalad.podbean.com, or can be subscribed to at the iTunes store by using keyword “geek salad.”  Geek Salad is also available on Spotify,iTunes,  iHeart Radio and wherever else you get your podcasts! Also, check out the Podbean App where you can stream and download the entire Geek Salad archive right from your Android or iPhone!  You can get the app at either the Google Play Store or the Apple App Store!  Want Geek Salad swag?  Check out our new store on Tee Public, where you can get t-shirts, mugs, stickers, and so much other stuff!!!  Shop here! Geek Salad episodes are now also available to stream on YouTube.  “Like” and Subscribe to their channel at Geek Salad Podcast at www.youtube.com Contact Geek Salad at geeksaladradio@gmail.com.  Geek Salad is also available on Facebook under the group heading “Geek Salad Podcast.” Check out their website at www.geek-salad.com, and please subscribe to their Blue Sky feed: @geeksaladradio Geek Salad is intended for adult listeners and contains coarse language and profanity.  Listener discretion is advised.

You feel like your team just doesn't “get it”. But maybe it's you, the leader, that isn't getting it! In this episode, Kirk Behrendt brings back Jenni Poulos, one of ACT's amazing coaches, to reveal the two skills you need to build an aligned and committed team. Saying something once isn't communication! To learn how to inspire your team just by being clear, listen to Episode 977 of The Best Practices Show!Learn More About Jenni:Send Jenni an email: jenni@actdental.com Follow Jenni on ACT's Instagram: https://www.instagram.com/actdentalSend Courtney an email to learn more about ACT: courtney@actdental.com Send Gina an email to learn more about ACT: gina@actdental.com More Helpful Links for a Better Practice & a Better Life:Subscribe to The Best Practices Show: https://the-best-practices-show.captivate.fm/listenJoin The Best Practices Association: https://www.actdental.com/bpaDownload ACT's BPA app on the Apple App Store: https://apps.apple.com/us/app/best-practices-association/id6738960360Download ACT's BPA app on the Google Play Store: https://play.google.com/store/apps/details?id=com.actdental.join&hl=en_USJoin ACT's To The Top Study Club: https://www.actdental.com/tttGet The Best Practices Magazine for free: https://www.actdental.com/magazinePlease leave us a review on the podcast: https://podcasts.apple.com/us/podcast/the-best-practices-show-with-kirk-behrendt/id1223838218Episode Resources:Watch the video version of Episode 977: https://www.youtube.com/@actdental/videosRegister to ACT's BPA for their Strategic Vision Creator tool: https://join.actdental.com/users/sign_in?post_login_redirect=https%3A%2F%2Fjoin.actdental.com%2Fc%2Fpractice-coaching-tools%2Fstrategic-vision-creator-tool#emailRegister to ACT's BPA for their Chief Reminding Officer tool: https://join.actdental.com/users/sign_in?post_login_redirect=https%3A%2F%2Fjoin.actdental.com%2Fc%2Fpractice-coaching-tools%2Fcro-chief-reminding-officer#emailMain Takeaways:Alignment starts with the leader.Get aligned on what alignment really...

The TKI Crew returns from the Holiday Break! On Today's episode, Kamryn Stablein returns to discuss what it takes to develop as a goalkeeper and the upcoming TKI U West Coast Program in January! Great listen for young coaches, players and parents! Share your feedback! Send your comments or questions - contact@insidethe18media.com Video Link -https://www.theunionsports.com/feeds/2487937 And if you want to make sure you never miss an episode of any of our other fantastic  shows such as Gloves off w/ Saskia Webber & Inside the 18 w/ Michael Magid, all  you have to do is subscribe to the union gk app. For more info go to www.theuniongk.com or Download the Union GK Community, on apple or google play stores. Thanks for making The Union Possible & on with the show! *If you want us to come to your town; all you've got to do is DM us @goalkeeperpodcast on The Union & tell us what you've got in mind. The Following is a FREE Preview of the popular TKI Podcast. Want to continue watching or listening? Then Join a 30 day free trial of The Union GK App the new exclusive home of  the pod. For more info; go to www.theuniongk.com ; or download the The Union GK Community on Apple or Google Play Stores. Thanks for all your support & we'll see you on The Union!   Unlock Excellence with UNION GK APP Premium Features: One-On-One Virtual Coaching Sessions: Meet with world-class coaches and goalkeepers to discuss your performance, technical assessments, the college recruiting process, and more. Personalized Training Plans: Access to tailored training plans designed by professional goalkeepers to enhance skills and understanding of the position. Exclusive Drills Library: Unlimited access to the Union GK's goalkeeping drills and exercises Hosted by Simplecast, an AdsWizz company. See pcm.adswizz.com for information about our collection and use of personal data for advertising.

For the month of December, we look back at some favorite episodes of 2025. In this episode, Kirk Behrendt brings back Dr. Barrett Straub, ACT's CEO, to break down your production story and explain why you don't need as many patients as you think. Stop the churn-and-burn dentistry that's burning you out! To learn how to rewrite and improve your production story, listen to Episode 976 of The Best Practices Show!Learn More About Dr. Straub:Send Dr. Straub an email: barrett@actdental.com Join Dr. Straub on Facebook: https://www.facebook.com/barrett.d.straubMore Helpful Links for a Better Practice & a Better Life:Subscribe to The Best Practices Show: https://the-best-practices-show.captivate.fm/listenJoin The Best Practices Association: https://www.actdental.com/bpaDownload ACT's BPA app on the Apple App Store: https://apps.apple.com/us/app/best-practices-association/id6738960360Download ACT's BPA app on the Google Play Store: https://play.google.com/store/apps/details?id=com.actdental.join&hl=en_USJoin ACT's To The Top Study Club: https://www.actdental.com/tttGet The Best Practices Magazine for free: https://www.actdental.com/magazinePlease leave us a review on the podcast: https://podcasts.apple.com/us/podcast/the-best-practices-show-with-kirk-behrendt/id1223838218Episode Resources:Watch the video version of Episode 976: https://www.youtube.com/@actdental/videosRegister to ACT's BPA for their Financial GAPs Calculator: https://www.actdental.com/bpaMain Takeaways:There's more to the production story than just how much you produced.Analyze your annual patient value, active patient count, and gross production.Stop filling production gaps with more patients. Do more dentistry on less patients.Do you want to be a dentist that chases 4,000 patients or have fewer, right patients?Figure out your production story now so you can figure out how to write it going forward.Snippets:0:00 Introduction.1:27 Why we need a production story.2:34 Important KPIs you need to know.6:49 Do more per active patient.11:48 Countermeasures you can start today.15:44 ACT's BPA and TTT.Dr. Barrett Straub Bio:Dr. Barrett Straub practices general and sedation dentistry in Port Washington, Wisconsin. He has worked hard to develop his practice into a top-performing, fee-for-service practice that focuses on improving the lives of patients through dentistry.A graduate of Marquette Dental School, Dr. Straub's advanced training and...

Freedom is what drew you to dentistry. But somehow, you're stuck working harder, earning less, and with less control of your time and life. In this episode, Kirk Behrendt brings back Miranda Beeson, ACT's director of education, to share the key to impacting your freedom and profitability: understanding and mastering write-offs. To learn how to lower your write-offs so you can take back your time and money, listen to Episode 975 of The Best Practices Show!Learn More About Miranda:Send Miranda an email: miranda@actdental.com Follow Miranda on ACT's Instagram: https://www.instagram.com/actdentalSend Courtney an email to learn more about ACT: courtney@actdental.com More Helpful Links for a Better Practice & a Better Life:Subscribe to The Best Practices Show: https://the-best-practices-show.captivate.fm/listenJoin The Best Practices Association: https://www.actdental.com/bpaDownload ACT's BPA app on the Apple App Store: https://apps.apple.com/us/app/best-practices-association/id6738960360Download ACT's BPA app on the Google Play Store: https://play.google.com/store/apps/details?id=com.actdental.join&hl=en_USJoin ACT's To The Top Study Club: https://www.actdental.com/tttGet The Best Practices Magazine for free: https://www.actdental.com/magazinePlease leave us a review on the podcast: https://podcasts.apple.com/us/podcast/the-best-practices-show-with-kirk-behrendt/id1223838218Episode Resources:Watch the video version of Episode 975: https://www.youtube.com/@actdental/videosLearn more about Smile Source: https://smilesource.comLearn more about Clerri: https://clerri.comMain Takeaways:Figure out your effort gap, collections gap, overhead gap, and your cash flow gap.Know how many days a month you work, and how many you're working for free.Always put in your full fee. You may have more elective write-offs than you think.Evaluate your membership plan. How much are you charging versus writing off?Determine how much you're writing off by being part of an insurance plan.Eliminate emotional discounting. Learn to charge what you're worth.Start celebrating net production rather than gross production.Snippets:0:00 Introduction.0:57 Smile Source and ACT have merged!3:23 Why understanding write-offs is important.8:15 ACT's core focus and core purpose.9:34 ACT's GAPs

30 years is a long time, and it seems like it was just yesterday that the movies of 1995 were released! Join Geek Salad along with their friends Em from the Verbal Diorama Podcast (available wherever you get your podcasts) and Kurt Smith (check him out on Letterboxed) as they discuss the highlights of the cinematic year. In this 2 part installment, they discuss the top US hits of the year (Part 1) and the other notable released (Part 2) Geek Salad is available at www.geeksalad.podbean.com, or can be subscribed to at the iTunes store by using keyword “geek salad.”  Geek Salad is also available on Spotify,iTunes,  iHeart Radio and wherever else you get your podcasts! Also, check out the Podbean App where you can stream and download the entire Geek Salad archive right from your Android or iPhone!  You can get the app at either the Google Play Store or the Apple App Store!  Want Geek Salad swag?  Check out our new store on Tee Public, where you can get t-shirts, mugs, stickers, and so much other stuff!!!  Shop here! Geek Salad episodes are now also available to stream on YouTube.  “Like” and Subscribe to their channel at Geek Salad Podcast at www.youtube.com Contact Geek Salad at geeksaladradio@gmail.com.  Geek Salad is also available on Facebook under the group heading “Geek Salad Podcast.” Check out their website at www.geek-salad.com, and please subscribe to their Blue Sky feed: @geeksaladradio Geek Salad is intended for adult listeners and contains coarse language and profanity.  Listener discretion is advised.  

Re-RunSeptember 16th, 2025The Art of Negotiating-JACKED UP DAILY!In this episode, Jack talks about the Art of Negotiating. How well does America do it, and is it easy for you to learn? Where does one learn to negotiate?Our website is www.LetsGetJackedUp.com Welcome to Jacked Up Daily with Tim, Jack, Bobby, and Karen, a dynamic daily podcast on the Fringe Radio Network. Tune in Monday through Friday at 7 AM for conservative commentary, Bible prophecy, and insights from a modern American Christian perspective. Based in Fresno, California, in the heart of the Central Valley, Jacked Up Daily brings a unique West Coast viewpoint to everything from politics and social issues to fringe topics like aliens, ghosts, and the anti-Christ. Whether discussing the rapture, end times prophecy, or offering analysis on current events, this show is perfect for your morning drive. Catch the latest episode on FringeRadioNetwork.com and join us as we explore the mysteries of the world from a bold, Christian viewpoint. Don't miss a moment of this thought-provoking and engaging show, where no topic is off-limits!FringeRadioNetwork.com LetsGetJackedup.com  E-mail us at letsgetjackedup@gmail.comFollow us on X @LetsGetJackedUp  and FacebookNote: Straw Hat Pizza Bar & Grill is no longer a sponser, due to location change. check out www.christianrock.net 24/7 or download the app from Google Play Store or Apple Store.

You're working hard, and you're super busy. So, why is your bank account empty? In this episode, Kirk Behrendt brings back Christina Byrne, ACT's director of operations, to help you understand the different financial gaps where your profit may be hiding. Don't let your hard-earned money slip through the cracks! To learn how to keep more of what you produce, listen to Episode 974 of The Best Practices Show!Learn More About Christina:Send Christina an email: christina@actdental.com Send Courtney an email to learn more about ACT: courtney@actdental.com More Helpful Links for a Better Practice & a Better Life:Subscribe to The Best Practices Show: https://the-best-practices-show.captivate.fm/listenJoin The Best Practices Association: https://www.actdental.com/bpaDownload ACT's BPA app on the Apple App Store: https://apps.apple.com/us/app/best-practices-association/id6738960360Download ACT's BPA app on the Google Play Store: https://play.google.com/store/apps/details?id=com.actdental.join&hl=en_USJoin ACT's To The Top Study Club: https://www.actdental.com/tttGet The Best Practices Magazine for free: https://www.actdental.com/magazinePlease leave us a review on the podcast: https://podcasts.apple.com/us/podcast/the-best-practices-show-with-kirk-behrendt/id1223838218Episode Resources:Watch the video version of Episode 974: https://www.youtube.com/@actdental/videosRegister to ACT's BPA for their GAPs at a Glance tool: https://join.actdental.com/users/sign_in?post_login_redirect=https%3A%2F%2Fjoin.actdental.com%2Fc%2Fpractice-coaching-tools%2Ffinancial-gaps-at-a-glance#emailRegister to ACT's BPA for their PPO Freedom course: Sign in | Best Practices AssociationMain Takeaways:You may be losing a significant amount of money from your different financial gaps.Working harder isn't the answer. Find where money is leaking from your practice.Know your effort gap. Being busy doesn't equal more profitability and success.Understand your collections gap. Collecting 96% isn't as good as it sounds.Be aware of your overhead gap. Be smart with spending and budgeting.Pay attention to your cash flow gap so you understand true profit.Snippets:0:00 Introduction.1:42 Why this is an important topic.2:52 The effort gap.9:57 The...

RE-RUNOctober 13, 2025Super Covid-JACKED UP DAILY!Jack and Tim will explore:The role of biotech and philanthropic figures, including speculation surrounding Bill Gates, pandemic preparedness funding, and public perception.FringeRadioNetwork.com LetsGetJackedup.com  E-mail us at letsgetjackedup@gmail.comFollow us on X @LetsGetJackedUp  and Facebookgo to www.StrawHatPizza.com to order your pizza if you live in Clovis or Fresno Californiacheck out www.christianrock.net 24/7 or download the app from Google Play Store or Apple Store.Note: Straw Hat Pizza Bar & Grill is no longer a sponser due to the company moving out of our local area.

We've gotten the dirt sheet on the opposition, but is there more to surmise? Can FC Cincinnati ride momentum to achieve the heights from two years ago? What actually are the chances that the underdog wins? (And when we say "underdog", are we actually talking about Inter Miami?) We sit down with Jake Zivin, the play-by-play broadcaster for Sunday's Eastern Conference semifinal matchup at TQL. It's easy to give opinions on the MVP candidates and designated players, but who does Jake think could play the X-factor? Is there anything either squad should avoid from their respective mid-series losses? Tune in and trade threads with us! #MLS #FCCincinnati #soccer Become a Patron! Subscribe to Cincinnati Soccer Talk Don't forget you can now download and subscribe to Cincinnati Soccer Talk on iTunes today! The podcast can also be found on Stitcher Smart Radio now. We're also available in the Google Play Store and NOW ON SPOTIFY! As always we'd love your feedback about our podcast! You can email the show at feedback@cincinnatisoccertalk.com. We'd love for you to join us on our Facebook page as well! Like us at Facebook.com/CincinnatiSoccerTalk.

The TKI Crew keeps their Fall Season Rolling Along w/ another smash episode! On Today's Former USWNT GK Jill Loyden discusses 5 specific jobs of the goalkeeper. Great listen for young coaches, players and parents! Share your feedback! Send your comments or questions - contact@insidethe18media.com Video Link -https://www.theunionsports.com/feeds/2487937 And if you want to make sure you never miss an episode of any of our other fantastic  shows such as Gloves off w/ Saskia Webber & Inside the 18 w/ Michael Magid, all  you have to do is subscribe to the union gk app. For more info go to www.theuniongk.com or Download the Union GK Community, on apple or google play stores. Thanks for making The Union Possible & on with the show! *If you want us to come to your town; all you've got to do is DM us @goalkeeperpodcast on The Union & tell us what you've got in mind. The Following is a FREE Preview of the popular TKI Podcast. Want to continue watching or listening? Then Join a 30 day free trial of The Union GK App the new exclusive home of  the pod. For more info; go to www.theuniongk.com ; or download the The Union GK Community on Apple or Google Play Stores. Thanks for all your support & we'll see you on The Union!   Unlock Excellence with UNION GK APP Premium Features: One-On-One Virtual Coaching Sessions: Meet with world-class coaches and goalkeepers to discuss your performance, technical assessments, the college recruiting process, and more. Personalized Training Plans: Access to tailored training plans designed by professional goalkeepers to enhance skills and understanding of the position. Exclusive Drills Library: Unlimited access to the Union GK's goalkeeping drills and exercises Hosted by Simplecast, an AdsWizz company. See pcm.adswizz.com for information about our collection and use of personal data for advertising.

Has your pulse returned to normal yet? After scratching out a seismic win that may have altered the soccer landscape in Ohio, the Orange & Blue have to take on the GOAT in the Eastern Conference Semifinals. The victor between FC Cincinnati and Inter Miami just might be the heavy favorite to win the East. While Cincinnati has had Miami's number this season, we know what happened the last time both teams squared off in an elimination game. Can either side reverse-jinx the other? We bring back Kris from the Battered Herons to ask his thoughts on this season's Miami squad. Yes, Messi has just about everyone else's number, but is it possible to constrain the potent offense and pierce the susceptible defense? Does Miami need to tinker with the team, or is the performance displayed against Nashville enough to move on? Tune in and trade threads with us! #MLS #FCCincinnati #soccer Become a Patron! Subscribe to Cincinnati Soccer Talk Don't forget you can now download and subscribe to Cincinnati Soccer Talk on iTunes today! The podcast can also be found on Stitcher Smart Radio now. We're also available in the Google Play Store and NOW ON SPOTIFY! As always we'd love your feedback about our podcast! You can email the show at feedback@cincinnatisoccertalk.com. We'd love for you to join us on our Facebook page as well! Like us at Facebook.com/CincinnatiSoccerTalk.