Podcasts about Reactive oxygen species

Chris Duffin welcomes Rahul Desai, a renowned expert in regenerative orthopedic medicine and founder of Restore PDX and Redvive. Join us as we explore Rahul's journey from radiology to regenerative medicine, where his innovative techniques in tissue regeneration have set new standards in the field. Delving into the world of red light therapy, or photobiomodulation, Rahul shares fascinating insights into its impact on enhancing tissue recovery, reducing inflammation, and accelerating healing. Discover how precision diagnosis and cutting-edge therapeutic approaches are helping people overcome musculoskeletal challenges and unlock their true strength. Rahul Desai always had a fascination with the human body and initially aspired to specialize in orthopedics and sports medicine. His journey through medical school led him to St. Jude's Children's Hospital, where he discovered a profound interest in radiology, specifically musculoskeletal interventional radiology. Captivated by the precision and technology involved, he became adept at using imaging techniques like MRIs, CAT scans, live X-rays, and ultrasounds to guide procedures such as steroid injections, biopsies, and device placements. Rahul's career path, marked by serendipity and passion, showcases his dedication to advancing medical interventions through innovative imaging techniques.   Check out Restore PDX: https://www.restorepdx.com/energy-based-medicine/   Regenerative Medicine Techniques Explanation of PRP and its effects on tissue healing. Introduction to cell therapy using bone marrow and fat for stem cells. Presentation of case studies involving regenerative medicine, including recovery from tendon and ligament injuries. Photobiomodulation (Red Light Therapy) Introduction of photobiomodulation as a complementary therapy. Benefits observed in terms of sleep improvement, HRV (Heart Rate Variability), and stem cell activation. Discussion of studies highlighting photobiomodulation's impact on stem cell circulation and cellular health.   This episode of the ARCHITECT of RESILIENCE podcast is available on Apple, Spotify & YouTube, and is sponsored by  @marekhealth : Performance. Longevity. Optimization.

Martin Kampmann, Ph.D., explores how CRISPR screening and induced pluripotent stem cell (iPSC) technology can uncover new insights into neurological diseases such as Alzheimer's. His lab uses CRISPR to identify genes that influence protein aggregation and cellular vulnerability, focusing on neurons, astrocytes, and microglia derived from human stem cells. Kampmann highlights the roles of mitochondria, autophagy, and other cellular pathways in disease progression, emphasizing the importance of understanding both protective and damaging processes. He also discusses the potential contributions of glial cells—especially microglia and astrocytes—to neurodegeneration, sparking ideas for therapeutic targets. Series: "Stem Cell Channel" [Health and Medicine] [Science] [Show ID: 39461]

Martin Kampmann, Ph.D., explores how CRISPR screening and induced pluripotent stem cell (iPSC) technology can uncover new insights into neurological diseases such as Alzheimer's. His lab uses CRISPR to identify genes that influence protein aggregation and cellular vulnerability, focusing on neurons, astrocytes, and microglia derived from human stem cells. Kampmann highlights the roles of mitochondria, autophagy, and other cellular pathways in disease progression, emphasizing the importance of understanding both protective and damaging processes. He also discusses the potential contributions of glial cells—especially microglia and astrocytes—to neurodegeneration, sparking ideas for therapeutic targets. Series: "Stem Cell Channel" [Health and Medicine] [Science] [Show ID: 39461]

Martin Kampmann, Ph.D., explores how CRISPR screening and induced pluripotent stem cell (iPSC) technology can uncover new insights into neurological diseases such as Alzheimer's. His lab uses CRISPR to identify genes that influence protein aggregation and cellular vulnerability, focusing on neurons, astrocytes, and microglia derived from human stem cells. Kampmann highlights the roles of mitochondria, autophagy, and other cellular pathways in disease progression, emphasizing the importance of understanding both protective and damaging processes. He also discusses the potential contributions of glial cells—especially microglia and astrocytes—to neurodegeneration, sparking ideas for therapeutic targets. Series: "Stem Cell Channel" [Health and Medicine] [Science] [Show ID: 39461]

Martin Kampmann, Ph.D., explores how CRISPR screening and induced pluripotent stem cell (iPSC) technology can uncover new insights into neurological diseases such as Alzheimer's. His lab uses CRISPR to identify genes that influence protein aggregation and cellular vulnerability, focusing on neurons, astrocytes, and microglia derived from human stem cells. Kampmann highlights the roles of mitochondria, autophagy, and other cellular pathways in disease progression, emphasizing the importance of understanding both protective and damaging processes. He also discusses the potential contributions of glial cells—especially microglia and astrocytes—to neurodegeneration, sparking ideas for therapeutic targets. Series: "Stem Cell Channel" [Health and Medicine] [Science] [Show ID: 39461]

Martin Kampmann, Ph.D., explores how CRISPR screening and induced pluripotent stem cell (iPSC) technology can uncover new insights into neurological diseases such as Alzheimer's. His lab uses CRISPR to identify genes that influence protein aggregation and cellular vulnerability, focusing on neurons, astrocytes, and microglia derived from human stem cells. Kampmann highlights the roles of mitochondria, autophagy, and other cellular pathways in disease progression, emphasizing the importance of understanding both protective and damaging processes. He also discusses the potential contributions of glial cells—especially microglia and astrocytes—to neurodegeneration, sparking ideas for therapeutic targets. Series: "Stem Cell Channel" [Health and Medicine] [Science] [Show ID: 39461]

Martin Kampmann, Ph.D., explores how CRISPR screening and induced pluripotent stem cell (iPSC) technology can uncover new insights into neurological diseases such as Alzheimer's. His lab uses CRISPR to identify genes that influence protein aggregation and cellular vulnerability, focusing on neurons, astrocytes, and microglia derived from human stem cells. Kampmann highlights the roles of mitochondria, autophagy, and other cellular pathways in disease progression, emphasizing the importance of understanding both protective and damaging processes. He also discusses the potential contributions of glial cells—especially microglia and astrocytes—to neurodegeneration, sparking ideas for therapeutic targets. Series: "Stem Cell Channel" [Health and Medicine] [Science] [Show ID: 39461]

Martin Kampmann, Ph.D., explores how CRISPR screening and induced pluripotent stem cell (iPSC) technology can uncover new insights into neurological diseases such as Alzheimer's. His lab uses CRISPR to identify genes that influence protein aggregation and cellular vulnerability, focusing on neurons, astrocytes, and microglia derived from human stem cells. Kampmann highlights the roles of mitochondria, autophagy, and other cellular pathways in disease progression, emphasizing the importance of understanding both protective and damaging processes. He also discusses the potential contributions of glial cells—especially microglia and astrocytes—to neurodegeneration, sparking ideas for therapeutic targets. Series: "Stem Cell Channel" [Health and Medicine] [Science] [Show ID: 39461]

Today, we're diving deep into biohacking your body's performance—starting with your VO2 max and mitochondria. We're sitting down with cellular optimization expert, Rowena Gates, to dive into how the NanoVi device is disrupting the world of biohacking, recovery, and training. First up, we're breaking down VO2 max—the secret sauce to longevity. Forget endless hours of cardio. Learn how to hack your VO2 max efficiently and add years to your life, without grinding it out in the gym. Then, we tackle the hidden world of reactive oxygen species (ROS). These little molecules can be both your friend and foe—boosting energy or fast-tracking aging. We'll show you how to control them, so you can keep your energy levels high and your body youthful. Finally, we explore the cutting-edge science of protein folding and exclusion zone water. Sound complicated? Don't worry, we'll break it down and show how NanoVi tech supercharges your mitochondria, giving you faster recovery and more endurance, all with minimal effort. Sponsors: Eng3 Special Offer Code: https://eng3corp.com/dave/ Resources: Rowena Gates' Website: https://www.eng3corp.com NanoVi Device: https://www.eng3corp.com/nanov Rowena Gates' LinkedIn: https://www.linkedin.com/in/rowenagates/ Dave Asprey's Linktree: https://linktr.ee/daveasprey Dave Asprey's Book ‘Smarter Not Harder' is out now: https://daveasprey.com/books Danger Coffee by Dave Asprey: https://www.instagram.com/dangercoffeeofficial/ Supplements by Dave Asprey: https://shopsuppgradelabs.com Join The Human Upgrade Podcast Live – Upgrade Collective: https://www.ourupgradecollective.com Own an Upgrade Labs: https://ownanupgradelabs.com Timestamps and Highlights: 00:00 Introduction to Metabolic Health 00:38 The Importance of VO2 Max 02:34 Reactive Oxygen Species Explained 05:57 The Role of Water in Cellular Health 14:11 Mitochondrial Function and Longevity 20:25 Cognitive Function and Biohacking 21:45 Advanced Meditation and Mitochondria 22:09 Post-Exercise Recovery Insights 22:37 NanoVi and Athletic Performance 23:42 Pro Athletes and Biohacking 27:00 Mitochondrial Function and Health 33:24 NAD and Cellular Health 36:29 Biohacking for Modern Living 37:48 Conclusion and Final Thoughts See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

Has measuring mitochondrial health always seemed out of reach? Not anymore! In this Longevity episode, I am joined by Dr. Hemal Patel to discuss groundbreaking research that allows us to assess mitochondrial function through a simple at-home blood test.  We discuss how practices like meditation, breathing exercises, and even attending immersive retreats can dramatically improve mitochondrial health in as little as a week. We also dive into cell membrane composition and Dr. Patel's personal story of how he integrates meditation into his nightly routine for better sleep and creativity! Dr. Hemal Patel is a Tenured Professor and Vice-Chair for Research in the Department of Anesthesiology at the University of California, San Diego, and has a dual appointment as a VA Research Career Scientist and VA Research Pharmacologist at the VA San Diego Healthcare System. He is also the Chief Scientific Officer for Versea Discovery. He has made seminal contributions in shaping new investigation areas on defining the impact of membrane structure on cell, organ, and organismal physiology and metabolism with implications for cardiac ischemia-reperfusion injury, heart failure, diabetic cardiomyopathy, aging, pulmonary hypertension, cancer, and neurodegeneration.    Shop the Mescreen test and use code Longevity   Thank you to our sponsors for making this episode possible: Element Health: Use code Longevity when shopping at https://elementhealthsupply.com to save on your orders.  Neurohacker Collective: Visit http://qualialife.com/nathalie and use code NATHALIE  Berkeley Life: Head to Berkeleylife.com/Nat to browse their products and purchase your bundle at a discount.                                                                   Find more from Mescreen:  Website: https://mescreen.com/  use code Longevity when shopping!    Find more from Nathalie: YouTube: https://www.youtube.com/channel/UCmholC48MqRC50UffIZOMOQ  Join Nat's Membership Community: https://www.natniddam.com/bsp-community  Sign up for Nats Newsletter: https://landing.mailerlite.com/webforms/landing/i7d5m0  Instagram: https://www.instagram.com/nathalieniddam/  Website: www.NatNiddam.com    Facebook Group: https://www.facebook.com/groups/biohackingsuperhumanperformance  What We Discuss: 03:23 The Symbiotic Relationship Between Mitochondria and the Gut Microbiome 07:47 Genetics and Lifestyle Factors Influencing Mitochondrial Function 12:13 Measuring Mitochondrial Function: A Non-Invasive Approach 28:56 The Role of Reactive Oxygen Species and the Importance of Balance 31:18 Mescreen Test: Measuring Skeletal Muscle Mitochondrial Function 33:46 Improving Mitochondrial Function: Lipid Support, Autophagy, and Antioxidant Balance 36:33 The Significance of Cholesterol in Membrane Stability 38:34 Hypoxic Breathing: Activating an Endogenous System for Resilience 46:01 Choosing High-Quality Fats for Optimal Mitochondrial Health 49:28 The Transformative Power of Meditation and Dr. Joe Dispenza's Retreats 56:04 The Importance of Personalized Mitochondrial Health  

This week's episode we cover a small part of the semen anlysis that often gets overlooked, but is potentially playing a much bigger role than clinicians previously thought. A new study (PMID 38929625) shows how important Reactive Oxygen Species are to sperm health, but there's one factor in particular we're covering today: Leukocytes. What are they and why do we care? Find out more here. DRKELSEY gets you 20% off your first supplement order at thisisneeded.com Complimentary epidoes: 115, 62 Master your male fertility with HIS Confidence: https://ttc.kelseyduncan.com/hisconfidence Learn more about Fertility Confidence Method and how to get a research based Whole Couple Approach plan  & support for you fertility journey at https://downloads.kelseyduncan.com/results 

In this episode of The Best You Podcast, we sit down with Chris Burres, founder and chief scientist at MyVitalC, to explore the secrets of longevity. Chris shares insights about ESS60, a groundbreaking molecule that has been shown to extend the lifespan of mammals by up to 90%. Imagine the possibility of living up to 152 years! We also discuss the dangers of Reactive Oxygen Species and the crucial roles that glutathione and melatonin play in longevity. Chris emphasizes the importance of an anti-inflammatory diet and antioxidants, and he reveals the top three factors that longevity experts believe are essential for living a longer, healthier life.Key Takeaways:●      ESS60 Molecule: Discover the molecule that can extend lifespan by up to 90%.●      Reactive Oxygen Species: Learn about the dangers and how to combat them.●      Glutathione and Melatonin: Understand their roles in longevity.●      Anti-Inflammatory Diet: Importance for longevity.●      Antioxidants: Why they are crucial for a longer life.●      Top Longevity Factors: The three most important factors for living longer according to experts.Don't miss this episode packed with actionable tips and expert advice on how to live a longer, healthier life. Tune in to get closer to your Best You!Topics Discussed:This MAIN molecule can double your lifespan! 1:43The Secret to Longer Life 23:44Longevity Diet and Nutrition 30:47Want to Live Longer? 36:60 Links:www.myvitalc.com/bestyouhttps://www.livelongerandbetterbook.comhttps://www.instagram.com/chrisburreshttps://www.youtube.com/c/MyVitalCLearn more about Nick and Best You at www.nickcarrier.comTry the 1-Week FREE Trial of the 10-Week Transformation at: www.nickcarrier.com/freetrial

With the full reveal of The Mitochondrial Triad coming soon, it begs the question: why do I believe the focal point of our health, wellness, and, more precisely, our longevity is centered around or organelle friends, the mitochondria? And with the first two pillars being disclosed, in red light therapy and methylene blue, what is the third pillar? All of these questions are answered in today's solosode!For decades, the primary thesis for why we age was The Free Radical Theory of aging. However, this doesn't hold up in instances where someone consistently exercises (and, thus, produces more ATP that inherently produces more of the natural byproduct of free radicals) that leads to health- and longevity-promoting benefits. That's where The Mitochondrial Theory of Aging emerges and is currently the most respected postulation on why we age. However, the first rendition of this theory still included free radicals as a main culprit for aging; this was remedied in the second version, which removed free radicals as the central causation for aging and suggested the main source was in the numerous mechanisms lying within the mitochondria. Ultimately, this is the genesis that fuels the importance of The Mitochondrial Triad.After a thorough discussion on The Mitochondrial Theory of Aging, I cover the third pillar of The Mitochondrial Triad! I dive into the top 10 health benefits and numerous other health benefits that have been proven out in the research. Disclaimer: I never say the actual name of the third pillar and refer to it in this portion of the episode as, "the thing." Yes, I know... very descriptive. But you didn't think I would actually reveal it yet, did you?!  ​We'll save that for next week's episode...​ I hope you enjoy the information in today's solosode. Please share this episode with family, friends and colleagues if you find the content especially interesting and/or impactful.As always, light up your health! - Key Points: Podcast Kickoff (00:00:01 - 00:01:22)Mitochondrial Triad Focus (00:01:22 - 00:02:30)Collaboration and New Product (00:02:30 - 00:03:33)Mitochondrial Importance (00:03:33 - 00:05:15)Optimizing Mitochondrial Health (00:05:15 - 00:08:15)Virtuous Cycle and Longevity (00:08:15 - 00:09:49)Known Pillars and Anticipation (00:09:49 - 00:10:46)Mitochondrial Theory of Aging (00:10:46 - 00:12:25)Aging and Mitochondrial Theory (00:15:52 - 00:16:24)Mitochondrial DNA Changes (00:16:24 - 00:17:35)Impact of Mutations (00:17:35 - 00:18:40)Mitochondrial Reactive Oxygen Species (00:18:40 - 00:19:56)Dual Nature of Reactive Oxygen Species (00:19:56 - 00:21:30)Mitochondrial Dynamics (00:21:30 - 00:22:38)Impaired Mitophagy (00:22:38 - 00:23:43)Mitochondria in Atherogenesis (00:23:43 - 00:25:11)Somatic Mutations and Atherosclerosis (00:25:11 - 00:26:15)Book Recommendation (00:26:15 - 00:27:07)Deep Science Talk (00:27:23 - 00:28:46)Free Radicals and Mitochondrial Dysfunction (00:28:46 - 00:29:47)Bioenergetic Mosaic (00:29:47 - 00:30:19)Misunderstandings About Free Radicals (00:30:19 - 00:31:41)Mitochondrial Population Flux (00:31:41 - 00:32:49)Redox State and Transcription Factors (00:32:49 - 00:33:54)Third Pillar Revelation (00:33:54 - 00:39:32)User Reports and Mitochondrial Theory (00:39:32 - 00:40:46)Cosmetic Applications (00:40:46 - 00:41:43)Cancer Protection and Hair Growth (00:41:43 - 00:42:50)Scientific Interest and Applications (00:42:50 - 00:45:27)Excitement and Synergy (00:45:27 - 00:47:06)Closing Remarks and Next Episode (00:47:06 - 00:48:04) - Article from episode: Mitochondrial Aging and Age-Related Dysfunction of Mitochondria   Recommended book on mitochondria: Mitochondria and the Future of Medicine - Lee Know, MD - BioLight Bundles offers bundles of products that are 20% off... all year long! - Kindle version of Red Light Therapy Treatment Protocols eBook, 4th Edition - To learn more about red light therapy and shop for the highest-quality red light therapy products, visit https://www.biolight.shop - Dr. Mike's #1 recommendations: Grounding products: Earthing.com EMF-mitigating products: Somavedic Blue light-blocking glasses: Ra Optics - Stay up-to-date on social media: Dr. Mike Belkowski: Instagram LinkedIn   BioLight: Website Instagram YouTube Facebook

From phys.org

Join us on this episode of the Flex Diet Podcast for a riveting conversation with Dr. Dwayne Jackson as we explore the world of neuro-protection and the critical role nutrition plays in it. We dig into the potentially harmful effects of inflammation and how it can lead to chronic traumatic encephalopathy (CTE). We also highlight the importance of entering sports activities in the least inflammatory state possible and how a balanced diet and supplements can assist.If you enjoyed this podcast, you can get more from me at MikeTNelson.com/podcast. You can see all the other podcasts and guest episodes I've done. Then if you scroll down, you can subscribe to my Fitness Insider Newsletter.Episode Chapters:(0:00:01) - Neuro-Protection and Nutrition(0:07:57) - Colorful Diet(0:13:01) - Exploring Variety in Food and Supplements(0:24:38) - CBD's Impact on Immunosuppression and Neurology(0:29:43) - Microdosing Mushrooms and Lyon's Main(0:39:13) - BHB, Ketone Supplements for Concussions(0:51:40) - Podcast Disclaimer for Health AdviceConnect with Dr. Dwayne Jackson:InstagramWebsitePrevious Podcast:Flex Diet Podcast Episode 202: Cold water immersion and the body's regulation systems: An interview with Dr. Dwayne Jackson

Link to bioRxiv paper: http://biorxiv.org/cgi/content/short/2023.02.08.527761v1?rss=1 Authors: Konar, S., Hedges, C. P., Callon, K. E., Bolam, S. M., Leung, S., Cornish, J., Naot, D., Musson, D. S. Abstract: Clinically, there is a positive correlation between BMI and the risk of tendinopathy. However, the underlying mechanisms are not understood. Dyslipidaemia and increased circulating free fatty acids (FFA) are associated with increased BMI. We hypothesised that increased FFA concentrations negatively affect rat tendon-derived cells (rTDCs) through mitochondrial-mediated mechanisms. rTDCs were isolated and treated with oleic acid (OA), stearic acid (SA), and palmitic acid (PA). Cell viability was assessed using AlamarBlue assay, and gene expression using real-time PCR. Cell respiration and reactive oxygen species (ROS) production were measured using high-resolution respirometry and MitoSox staining. PA transport into the mitochondria was blocked by pre-treatment with 50 M etomoxir. Treatment with SA and PA at 10 g/ml decreased rTDC viability by 40% and 60%, respectively. PA decreased the gene expression of the tendon markers Scx and Tnmd, and increased the expression of Mmp3, Mmp13, and Ptgs2 (encoding Cox-2). FFA treatment increased the expression of Cpt1 and Pdk4, indicating an increase in mitochondrial FFA oxidation. PA, at 10 g/ml, increased cellular respiration and ROS production. Pre-treatment with etomoxir partially inhibited the effects of PA on cell viability, Mmp3 gene expression, ROS production, and cell respiration, but did not affect PA-induced inhibition of Scx or Tnmd expression. We found that increased saturated FFA concentrations in the microenvironment reduce cell viability and alter ROS production, respiration, and gene expression. Blocking PA transport into mitochondria partially reversed the negative effects of PA. Overall, an increase in saturated FFA concentrations may contribute to poor tendon health. Copy rights belong to original authors. Visit the link for more info Podcast created by Paper Player, LLC

Link to bioRxiv paper: http://biorxiv.org/cgi/content/short/2023.01.08.523174v1?rss=1 Authors: Hughes, J., McMorrow, K., Bovin, N., Miller, D. Abstract: Sperm storage by females after mating for species-dependent periods is used widely among animals with internal fertilization to allow asynchrony between mating and ovulation. Many mammals store sperm in the lower oviduct where specific glycans on epithelial cells retain sperm to form a reservoir. Binding to oviduct cells suppresses sperm intracellular Ca2+ and increases sperm longevity. We investigated the mechanisms by which a specific oviduct glycan, 3-O-sulfated Lewis X trisaccharide (suLeX), prolongs the lifespan of porcine sperm. Using targeted metabolomics, we report that binding to suLeX diminishes the abundance of the precursor to ubiquinone and suppresses formation of fumarate, a specific citric acid cycle component, diminishing the activity of the electron transport chain and reducing the production of harmful reactive oxygen species (ROS). The enhanced sperm lifespan in the oviduct may be due to suppressed ROS production as many reports have demonstrated toxic effects of high ROS concentrations on sperm. Copy rights belong to original authors. Visit the link for more info Podcast created by Paper Player, LLC

Link to bioRxiv paper: http://biorxiv.org/cgi/content/short/2022.10.16.512428v1?rss=1 Authors: Chintaluri, C., Vogels, T. P. Abstract: So-called spontaneous neuronal activity is a central hallmark of most nervous systems. Such non-causal firing is contrary to the tenet of spikes as a means of communication, and its origin and purpose remain unclear. Here, we propose that non-input driven firing can serve as a release valve to protect neurons from the toxic conditions arising in mitochondria from lower-than-baseline energy consumption. We built a framework of models that incorporate homeostatic control of metabolic products--ATP, ADP, and reactive oxygen species, among others--by way of changes in firing. Our theory can account for key features of neuronal activity observed in many experiments in studies ranging from ion channels function all the way to resting state dynamics. We propose an integrated, crucial role for metabolic spiking that bridges the gap between metabolic homeostasis and neuronal function. Finally, we make testable predictions to validate or falsify our theory. Copy rights belong to original authors. Visit the link for more info Podcast created by Paper Player, LLC

All platforms / Episode Show Notes: https://livelongerworld.substack.com/p/vgladyshev Dr. Vadim Gladyshev is a professor at Harvard Medical school and a Director of redox medicine at Brigham and Women's hospital, where he runs his own lab. We had a brilliant discussion which started off by talking about his work on selenium. Selenium is found is Brazil nuts and we discussed its connection to aging and cancer prevention, and also some of the harmful effects it can have. Dr. Gladyshev calls it the good, the bad, the ugly nature of selenium. Then, we discussed a fair bit on his theory of aging before and after development. Most people believe that the germline which is the reproductive cells do not age, but his lab's work has shown how the germline does in fact age. On this point, his lab also has interesting results on how rapamycin during development extended lifespan in mice. It's important to understand the basic science and understand more on the aging process in order to crack it. Dr. Gladyshev shares his views on this too and his research is certainly a step towards cracking the aging code. I hope you enjoy the conversation! Find the previous podcast episodes & subscribe to be notified: https://www.livelongerworld.com/podcast Sign up for Premium Subscriber Transcripts: https://www.livelongerworld.com/premium Support on Patreon: https://www.patreon.com/livelongerworldOne-Time support: https://www.paypal.com/paypalme/livelongerworld Find me on Twitter: https://twitter.com/livelongerworld VADIM GLADYSHEV LINKS: Website: https://gladyshevlab.bwh.harvard.edu/2022 Rapamycin During Development extends Lifespan: https://www.biorxiv.org/content/10.1101/2022.02.18.481092v1 LIVE LONGER WORLD LINKS: Website: https://www.livelongerworld.com/ Twitter: https://twitter.com/livelongerworld Newsletter: https://livelongerworld.substack.com/ Instagram: https://www.instagram.com/longevityfuture/ Patreon: https://www.patreon.com/livelongerworld YouTube: https://www.youtube.com/c/LiveLongerWorld Premium Subscriber: https://www.livelongerworld.com/premium TIMESTAMPS: 0:00 Vadim Gladyshev Intro 1:28 Live Longer World 2:17 Selenium's dual role in aging (the good, the bad, the ugly) 11:27 Antagonistic Pleiotropy 13:53 Selenium & Cancer 15:58 Selenium Dosage (don't get too much!) 18:30 Reactive Oxygen Species, Antioxidants & Aging 22:30 Fundamental basis of Aging 24:09 Aging is damage 29:20 Single cell Epigenetic Clocks 34:22 Aging in the Womb 42:16 Parent's lifestyle for aging in embryo 44:14 Rapamycin during development 49:06 Other compounds 51:53 Slowing Aging vs. Rejuvenation 56:08 New projects being worked on 57:17 Confidence level in extending lifespan within 30 years 59:17 Support Live Longer World Episode Show Notes: https://livelongerworld.substack.com/p/vgladyshev Live Longer World Season 1 Recap: https://livelongerworld.substack.com/p/season1 Thanks for watching & if you enjoy the episode, let's spread the message on longevity. You can support my work by sharing, liking, subscribing, leaving a review on Apple podcasts, donating on Patreon, or signing up as a premium member. Aging is universal. Let's unite in this fight. Stay in good health - Aastha.

In this Science & Chill podcast clip (from episode 38), Dr. Thomas Clanton explains the difference between free radicals and reactive oxygen species, and talks about the importance of these biological molecules. Listen to the full episode HERE.

In this podcast, Dr. Berg talks about ROS, which stands for Reactive Oxygen Species. It can either be free radical (unpaired electrons) or non-free radical involving oxygen. The body makes ROS and it can also be generated from the environment as well. The reason why the body makes ROS is that there is a natural process or a natural programmed cell death in the body called Apoptosis, a condition where the body is killing off certain cells that is essential for life. ROS has the ability to eliminate certain things that you don't want in the body. Ketones reduces excess ROS in the body and it can act as an antioxidant to protect the nerves. • Take Dr. Berg's Free Keto Mini-Course! • How to Bulletproof your Immune System Course • Dr. Berg's Beginner Guide to Healthy Keto & Intermittent Fasting Plan • Intermittent Fasting Basics for Beginners • Dr. Berg's Healthy Ketogenic Diet Basics: Step 1: https://youtu.be/vMZfyEy_jpI Step 2: https://youtu.be/mBqpaAKtnXE Dr. Eric Berg DC Bio: Dr. Berg, 51 years of age is a chiropractor who specializes in weight loss through nutritional & natural methods. His private practice is located in Alexandria, Virginia. His clients include senior officials in the U.S. government & the Justice Department, ambassadors, medical doctors, high-level executives of prominent corporations, scientists, engineers, professors, and other clients from all walks of life. He is the author of The 7 Principles of Fat Burning. Dr. Berg's Website: http://bit.ly/37AV0fk Dr. Berg's Recipe Ideas: http://bit.ly/37FF6QR Dr. Berg's Reviews: http://bit.ly/3hkIvbb Dr. Berg's Shop: http://bit.ly/3mJcLxg Dr. Berg's Bio: http://bit.ly/3as2cfE Dr. Berg's Health Coach Training: http://bit.ly/3as2p2q Facebook: https://www.facebook.com/drericberg Messenger: https://www.messenger.com/t/drericberg Instagram: https://www.instagram.com/drericberg/ YouTube: http://bit.ly/37DXt8C

Gold nanoparticles are becoming a promising platform for the delivery of drugs in the treatment of Oxidative Stress in Neurodegenerative diseases. Oxidative Stress has been considered as key modulator in Neurodegenerative diseases and the mitochondria, highly involved in the production of oxidant species, play a role in the etiology of the diseases. This project explores the opposite roles of gold nanoparticles to generate either physiological (beneficial) or pathological alterations on the cells depending on the active molecules attached on the surfaces of the nanoparticles. An antioxidant drug delivery nanoconjugate system - lipoic acid capped gold nanoparticle was synthesized based on the antioxidant lipoic acid, which was then applied against the Oxidative Stress caused by the aggregates of α-synuclein protein, a protein implicated in Parkinson's disease. The α-synuclein aggregation promoted by the gold nanoparticles enabled the self-assembly of toxic α-synuclein aggregates, which were responsible for increased level of Reactive Oxygen Species and consequently Oxidative Stress on the cells. Miss Maria Elena Piersimoni, PhD candidate at Imperial College London, currently also a Senior Scientist at PFIZER & UK. For Research Use Only. Not for use in diagnostic procedures. DE44320.2498032407

Thousands or Millions or billions… It's something like that, the number of free radicals that are running around your body ruining your arteries and cells. In fact, it’s been proven that free radicals contribute to cancer, Alzheimer's, cardiovascular disease, and Parkinson's. Whilst these are a natural part of the body’s function, what is not natural is the excessive volumes in which we produce these free radicals due to our toxic lives and diets. The good news is, we can do a lot about it.In This Episode I Covered:How free radicals are produced in both our body and in the environmentThe cellular events and damage that takes place when a free radical is presentWhat you can do to reduce your free radical load***Join the Facebook Group Here (formerly HH4H): https://www.facebook.com/groups/IntermittentFastingForHealth/***--SOCIAL MEDIA--MATTY LANSDOWNJoin the Facebook Group Here:https://www.facebook.com/groups/IntermittentFastingForHealth/Instagram: https://www.instagram.com/mattylansdown/--Thanks for checking out the show. If you enjoyed this episode and want to hear more then please consider subscribing. If you really loved this episode and want to just tell the world about it then please take a screenshot and share it on your Instagram story and be sure to tag me so I know you're tuning in. 5-star ratings and positive reviews really help the podcast too so thank you in advance!......Music credits:Intro/Outro track Tropic Love by "Diviners feat. Contacreast" www.youtube.com/watch?v=DoJfqJsGk8s

Motivation, Perception, and Chance Converge to Make a Binary Decision, Recurrent Circuitry Sustains Drosophila Courtship Drive While Priming Itself for Satiety,, Measures the Passage of Time to Coordinate Behavior and Motivational State, and Sleep Loss Can Cause Death through Accumulation of Reactive Oxygen Species in the Gut Prof. Dragana Rogulja is an assistant professor at Harvard Medical School. Her interests include sleep, circadian rhythms, and motivation. --- Send in a voice message: https://anchor.fm/scientificsense/message Support this podcast: https://anchor.fm/scientificsense/support

Question: Is increasing reactive oxygen species a good strategy for appetite control?Is that going to cause satiety in the brain? Maybe. I haven't studied that. I think Stephan Guyenet would be a great person to talk to about that. It wouldn't surprise me in the sense that if you want to shut down energy coming into the cell, why wouldn't you also want, at some bigger level, to shut down energy input into the body? I guess that makes sense. But I've mostly studied this in the case of outside the brain, peripherally, what is it doing? And what it's doing in adipose tissue or in skeletal muscle is it's shutting down glucose uptake, leading to hyperglycemia, and it's shutting down fatty acid uptake into the mitochondria leading to elevated free fatty acid levels, all of which are generally harmful to the body. Now this is an adaptively desirable thing because, let's say you have a trillion cells. If you would like to be part of the next live Ask Me Anything About Nutrition, sign up for the CMJ Masterpass, which includes access to these live Zoom sessions, a private discussion group, premium features on all my content, and hundreds of dollars of exclusive discounts. You can sign up at https://chrismasterjohnphd.com/masterpass/ and use the code QANDA to get 10% off the membership for life. For the remainder of 2020, I will be working full-time on finishing my Vitamins and Minerals 101 book, while reserving a portion of my time for consulting clients. You can pre-order my book at https://chrismasterjohnphd.com/book. You can sign up for a consultation at https://chrismasterjohnphd.com/consultations DISCLAIMER: I have a PhD in Nutritional Sciences and my expertise is in performing and evaluating nutritional research. I am not a medical doctor and nothing herein is medical advice.

Link to bioRxiv paper: http://biorxiv.org/cgi/content/short/2020.11.16.384487v1?rss=1 Authors: Dhawan, S., Myers, P., Landgraf, M. Abstract: Neurons utilize plasticity of dendritic arbors as part of a larger suite of adaptive plasticity mechanisms. This explicitly manifests with motoneurons in the Drosophila embryo and larva, where dendritic arbors are exclusively postsynaptic and are used as homeostatic devices, compensating for changes in synaptic input through adapting their growth and connectivity. We recently identified reactive oxygen species (ROS) as novel plasticity signals instrumental in this form of dendritic adjustment. ROS correlate with levels of neuronal activity and negatively regulate dendritic arbor size. Here, we investigated NADPH oxidases as potential sources of such activity-regulated ROS and implicate Dual Oxidase (but not Nox), which generates hydrogen peroxide extracellularly. We further show that the aquaporins Bib and Drip, but not Prip, are required for activity-regulated ROS-mediated adjustments of dendritic arbor size in motoneurons. These results suggest a model whereby neuronal activity leads to activation of the NADPH oxidase Dual Oxidase, which generates hydrogen peroxide at the extracellular face; aquaporins might then act as conduits that are necessary for these extracellular ROS to be channeled back into the cell where they negatively regulate dendritic arbor size. Copy rights belong to original authors. Visit the link for more info

Talk to a Dr. Berg Keto Consultant today and get the help you need on your journey (free consultation). Call 1-540-299-1556 with your questions about Keto, Intermittent Fasting, or the use of Dr. Berg products. Consultants are available Monday through Friday from 8 AM to 10 PM EST. Saturday & Sunday from 9 AM to 6 PM EST. USA Only. Get Dr. Berg's Veggie Solution today! • Flavored (Sweetened) - https://shop.drberg.com/veggie-solution-flavored-sweetened?utm_source=Podcast • Plain (Unflavored) - https://shop.drberg.com/veggie-solution-plain?utm_source=Podcast Take Dr. Berg's Free Keto Mini-Course! In this podcast, Dr. Berg talks about ROS, which stands for Reactive Oxygen Species. It can either be free radical (unpaired electrons) or non-free radical involving oxygen. The body makes ROS and it can also be generated from the environment as well. The reason why the body makes ROS is that there is a natural process or a natural programmed cell death in the body called Apoptosis, a condition where the body is killing off certain cells that is essential for life. ROS has the ability to eliminate certain things that you don't want in the body. Ketones reduce excess ROS in the body and it can act as an antioxidant to protect the nerves. Things that Causes the Body to Produce High Levels of ROS: • Metal Toxic • Chemical • UV Radiation • Exercise • Stress • Low Oxygen – Hypoxia • Pollution • Smoking • Infection Dr. Eric Berg DC Bio: Dr. Berg, 51 years of age is a chiropractor who specializes in weight loss through nutritional & natural methods. His private practice is located in Alexandria, Virginia. His clients include senior officials in the U.S. government & the Justice Department, ambassadors, medical doctors, high-level executives of prominent corporations, scientists, engineers, professors, and other clients from all walks of life. He is the author of The 7 Principles of Fat Burning. FACEBOOK: fb.me/DrEricBerg?utm_source=Podcast&utm_medium=Anchor TWITTER: http://twitter.com/DrBergDC?utm_source=Podcast&utm_medium=Post&utm_campaign=Daily%20Post YOUTUBE: http://www.youtube.com/user/drericberg123?utm_source=Podcast&utm_medium=Anchor DR. BERG'S SHOP: https://shop.drberg.com/?utm_source=Podcast&utm_medium=Anchor MESSENGER: https://www.messenger.com/t/drericberg?utm_source=Podcast&utm_medium=Anchor DR. BERG'S VIDEO BLOG: https://www.drberg.com/blog?utm_source=Podcast&utm_medium=Anchor

(This episode is in Serbian)Why do we sleep? The answer can seem obvious to everyone - because sleep helps us to rest, regenerate, preserve energy for the day ahead… However, the process that is so familiar to us remains among the most mysterious phenomena in biology – as a matter of fact, everything we just stated still remains at the level of the hypothesis. So why is sleep necessary for life? Dragana Rogulja teaches neurobiology at Harvard Medical School Blavatnik Institute of Neurobiology, has dedicated her career to researching the molecular mechanisms that govern sleep. For this purpose, Dragana and a team of scientists from Harvard examined Drosophila Melanogaster, because sleep in the fruit fly is remarkably similar to mammalian sleep. Dragana revealed to us that flies, in the absence of sleep, behave similarly to humans - lack of sleep leads to numerous disorders and diseases, even death. Through a conversation with Dragana, we learned not only about similarities between flies and humans, but we also heard in more details about her long-term research, which for the first time offered to science something more than hypotheses when it comes to question of our need to sleep. We encourage you to learn more about Dragana Rogulja's research at the following links:Rogulja Lab: http://roguljalab.hms.harvard.eduArticle: "Sleep Loss Can Cause Death through Accumulation of Reactive Oxygen Species in the Gut: https://www.dropbox.com/s/08f6yh5o9792kzf/Sleep%20ROS%20Gut%20Alex%20Yossi%20Keishi.pdf?dl=0 

不眠と寿命の関係をハエを使って調べた論文を紹介しました。 ハエは不眠になると腸に酸化ストレスが溜まり、それが原因で寿命を縮めることが証明されています。 専門的な内容を説明しつつも、研究者がどういう感情で論文を読んでいるかについて、力を入れて話しました。 文字起こし版 by keiさん（本編の音声の文字に起こしたものをnoteに上げてくれています） 「いんよう！」ブログ 原著論文 Sleep Loss Can Cause Death through Accumulation of Reactive Oxygen Species in the Gut 論文紹介/GIGAZINE/寝ないと死ぬ理由/実感/寝不足/Cell/Article/三大誌/第一印象/データ量がハンパない/gut/腸/活性酸素種/酸化ストレス/不眠のハエ/マウスで載る/マウスではやってない/mammal (マンマル、哺乳類)/ドラ/実験の質/インパクト/神経障害/腸に注目/研究のピーク/パチスロのフィーバー/不眠モデル/変異体ライブラリー/酵母/単細胞生物/多細胞生物/線虫/ショウジョウバエ/ドロソフィラ・メラノガスター/ゼブラフィッシュ/マウス/遺伝的操作/睡眠抑制神経/色々いじっても寝る/食欲と睡眠欲/睡眠のリバウンド/材料ができたら半分勝ち/ポジティブデータしか載せない/陽イオンチャンネル/脱分極/特異的プロモーター/温度感受性変異体/29度にすると不眠/Figure 1で7個/ハーバード・メディカルスクール/時系列データ/振動を与え続けて寝かせない/DNA障害/抗酸化作用/アポトーシス/手順に則る/サポーティブ・データ/バーを回す/脳波測定/手間がかかりすぎる/手役/抗酸化酵素/原因か結果か/論文紹介ブログ/科学ニュース/論文のまとめページ/グラフィカルアブストラクト/情報効率/言葉だけ拾う/何の役にも立たない/ぜんぜん証明されてない/ワインとか飲む/ポリフェノール/分からなかったけど面白かったです

Brad Marshall is a researcher of Reactive Oxygen Species with a degree in genetics from Cornell University. He is focused on creating the most healthy meats possible, and his current research has led him to study polyunsaturated fatty acids and their negative effect on human health & performance. Subscribe to the Podcast on on Platforms! ➢ https://lnk.to/PowerProjectPodcast Support the show by visiting our sponsors! ➢Piedmontese Beef: https://www.piedmontese.com/ Use Code "POWERPROJECT" at checkout for 25% off your order plus FREE 2-Day Shipping on orders of $99 ➢Icon Meals: http://iconmeals.com/ Use Code "POWERPROJECT" for 10% off ➢Sling Shot: https://markbellslingshot.com/ Enter Discount code, "POWERPROJECT" at checkout and receive 15% off all Sling Shots Follow Mark Bell's Power Project Podcast ➢ Insta: https://www.instagram.com/markbellspowerproject ➢ https://www.facebook.com/markbellspowerproject ➢ Twitter: https://twitter.com/mbpowerproject ➢ LinkedIn:https://www.linkedin.com/in/powerproject/ ➢ YouTube: https://www.youtube.com/markbellspowerproject ➢TikTok: http://bit.ly/pptiktok FOLLOW Mark Bell ➢ Instagram: https://www.instagram.com/marksmellybell ➢ Facebook: https://www.facebook.com/MarkBellSuperTraining ➢ Twitter: https://twitter.com/marksmellybell ➢ Snapchat: marksmellybell ➢Mark Bell's Daily Workouts, Nutrition and More: https://www.markbell.com/ Follow Nsima Inyang ➢ Instagram: https://www.instagram.com/nsimainyang/ Podcast Produced by Andrew Zaragoza ➢ Instagram: https://www.instagram.com/iamandrewz #PowerProject #Podcast #MarkBell

As temperatures rise, our crops can succumb to stress that might have detrimental effects on our yields and quality this year and next year. Permanent Crop Manager, Devin Clarke grows our knowledge with some nutritional strategies that can mitigate these stresses and keep us on track for successful harvests.  Calcium in the right form, applied at the right time and rate can help our trees reduce the production of Reactive Oxygen Species that damage RNA, DNA, and proteins that are necessary for effective photosynthesis and carbohydrate formation.  Properly applied Calcium can help indirectly with Potassium to develop guard cells that help plants transpire and cool themselves.  

Vitamin C, or Ascorbic Acid, is an essential part of a fully-functioning redox system. Doris Loh discusses the Redox system, Electromagnetic Radiation, and the foundational role Vitamin C plays in human optimization. Who is Doris Loh? Doris Low is a medical researcher and writer specializing in the investigation of familiar and innovative health topics using unique perspectives, and traditional and quantum biology. Her training as a classical pianist allows her the freedom to explore concepts and theories with a curiosity that often results in distinctive conclusions. Recent works by Doris include an in-depth series on deuterium and a startling two-part series on the quantum properties of vitamin C. Highlights [3:00] Reactive Oxygen Species and today's environment [8:10] Electromagnetic radiation and oxidative stress [10:55] The electromagnetic radiation issue in detail [17:00] 2002 World Health Organization ruling around ELF/EMF [26:18] The role of Vitamin C in the Redox system [29:42] NADH, Vitamin C, and low carbohydrate diets [34:49] Comparing Vitamin C and Ascorbic Acid [37:29] Vitamin C Dosing [40:24] Addressing the naysayers around supplementation [44:12] The final four questions Resources The Journey of Souls by Dr. Michael Newton Vitamin C & Mitochondria Part 1 Redox in a 5G World by Doris Loh Deuterium, Quantum Paradox: Light Water & Magnetism by Doris Loh Deuterium 101: Chapter 3, Microbiome by Doris Loh Deuterium 101: Chapter 2, You are What You Eat Deuterium 101: Chapter 1, Measuring Deuterium by Doris Loh Uric Acid, Vitamin C, and EMR Continue Your High-Performance Journey with Doris Loh Doris Loh on LinkedIn Sponsor Our sponsor for today’s show is one of the two brands of blue light blockers that I actually recommend using. I’ve had the CEO Matt Maruca on the show before and we got into a two-hour-long discussion, which I think to this day is the longest episode of the Decoding Superhuman podcast. But his company raw optics has made blue light blockers sexy. And the beauty of their product is that blue light doesn’t get in. If any amount of blue light gets in, that Netflix show you’re watching late at night, that book that you’re reading on your iPad, that email that you’re answering, is disrupting your sleep. So where do you get yours? Head over to raoptics.com plugin the code Boomer you’ll get 10% off your order. Disclaimer This information is being provided to you for educational and informational purposes only. This is being provided as a self-help tool to help you understand your genetics, biodata and other information to enhance your performance. It is not medical or psychological advice. Virtuosity LLC is not a doctor. Virtuosity LLC is not treating, preventing, healing, or diagnosing disease. This information is to be used at your own risk based on your own judgment. For the full Disclaimer, please go to (Decodingsuperhuman.com/disclaimer). See acast.com/privacy for privacy and opt-out information.

In this episode, I talk a little about my thoughts on post-workout strategies when exercising on the ketogenic diet. Great books to read regarding the science behind all of this: The Art And Science Of Low Carbohydrate Performance Mike Mutzel's thoughts on intra workout carbs: https://www.youtube.com/watch?v=2s7Xwo2WAlA Recovery is the key to progression within endurance training. If you are training, and not fully recovering, then you're going to be putting yourself at risk of injury and overtraining. There are so many ways to recover, but the best way to recover your legs from a long or hard run is to use a combination of the most Cold Therapy By jumping into a cold shower or pool post workout is a great way to reduce DOMS (Delayed Onset Muscle Soreness). If you have access to an ice bath, this is even better. Not only does this help with muscle recovery, but I've also found that it helps recover joints that might be sore. Foam Rolling / Stretching The most effective foam rolling I've found is on the calves (sitting position, one leg on top of the other, rolling over your calf muscle), hamstrings, quads (superman rolling over your quad muscles), and a hip flexor stretch (by kneeling, and pushing forward through your front knee and maintaining a tall upright posture). Post Workout Food Aside from replenishing your hydration levels (which is also important), following a ketogenic diet means that you'll need to be eating enough fat to be sustaining energy requirements, so I usually finish a run by eating eggs, with either smoked salmon, bacon, avocado or even bulletproof coffee. Keep it simple. Note on carbohydrates after exercise: • Consuming carbohydrates post workout rapidly decreases fatty acid oxidation in the muscles, thereby interfering with keto adaptation, and diminishes the beneficial effects of exercise on insulin sensitivity. • Avoiding blood sugar and insulin spikes can lessen the stress response to exercise • Finnish researchers - The post marathon Paradox – more insulin resistance 3 days post marathon. • Consuming carbs post workout can also have a rebound effect resulting in low blood sugar and stress responses that will release additional epinerpherine and cortisol, which can hinder recovery. • By elevating insulin levels post exercise with fast acting carbs can point glucose into fat storage. • Membrane highly unsaturated fatty acids (HUFA) is linked with insulin sensitivity, so reduction in these essential fatty acids within the muscle membranes could impair insulin sensitivity. Keto adapted athletes are better protected against this damage. • When you burn oxygen, your body creates Reactive Oxygen Species which damages HUFA membranes. Keto diet has shown to have an increased amount of HUFA to start with. • Consuming enough Omega 3 in the diet maintains optimum tissue levels of HUFA • Less generation of reactive oxygen species (ROS) better preservation of highly unsaturated fatty acids in cell membranes • Higher ketone levels means less mitochondrial ROS production, and increases in antioxidant defences. • Less metabolic stress, improved fuel flow and healthier membranes means faster recovery from exercise and less inflammation, Less immunosuporession, Less gasto-intestinal distress, less insulin resistance.

Today’s first bilingual episode dives into the benefits or lack of using antioxidants supplements to improve recovery, muscle soreness, and training adaptations. For spanish version skip to minutes 21:00 for to the second part of this episode (Para episodio en espanol porfavor salta el episodio al minuto 21:00) Antioxidant supplementation has been a hot topic in the past couple of years. We know that increased oxidative stress through increased production of free radicals (also known as Reactive Oxygen Species or ROS). Antioxidant support and increased antioxidant intake through foods and supplements has been a topic of discussion. Today I especifically chat about whether or not they can help you recover faster, and/if they can help with muscle soreness. Articles/Resources discussed in this episode: Antioxidants for preventing and reducing muscle soreness after exercise. Do antioxidant supplements interfere with skeletal muscle adaptation to exercise training? To connect with me: On Instagram www.instagram.com/vivenutrition and if you want to stay-up-to-date on these episodes www.instagram.com/vivenutritionradio On Youtube www.youtube.com/c/vivenutrition On Facebook www.facebook.com/vivenutrition For nutrition coaching apply at www.vive-nutrition.com/online-coaching If you want to get a FREE gift from me, make sure you subscribe a leave a review :)  

--- Support this podcast: https://anchor.fm/brad-richardson/support

Dr Marvin Berman recieved his PhD in Psychoeducational Processes. He is trained in Bioenergetic Analysis and is trained in numerous other therapeutic interventions including EEG biofeedback and the Feldenkrais methodologies. He consults with senior executives and management teams on the application of cognitive neuroscience in leadership development and performance. Recently, he is exploring the application of EEG biofeedback and related technologies into the treatment of neuropsychological and neurodegenerative disorders including Alzheimer's disease and Parkinson's. In Alzheimer's disease the brain shrinks over time. Certain forms of light energy may help defeat this problem.  Near infrared wavelengths are particularly good because not only do they travel deeper into tissues; they are not lost by being absorbed by blood and water before they reach the brain.   On this show we talk about two different and distinct technologies on this episode. One is Photobiomodulation the other is Neurofeedback. Neurofeedback we have talked about with Drs Majid Fotuhi (episode 3) and Dr David Merrill (episode 9). Photobiomodulation (PBM) introduces certain frequencies of light.  The light has an impact on the brain's mitochondria. Institutions like Harvard, Standford and MIT all have and continue to explore Photobiomodulation.  There are LED lights that are placed on head or shined into the nose and they seem to do a several beneficial things.  To be clear, the signaling within the (brain) tissue  takes place as a result of exposure to light (photonic) energy. The Key players in the PBM story are 1) Cytochrome C oxidase (substance that absorbs light) 2) ATP (energy and healing) 3) Reactive Oxygen Species - mild oxidant that signals cellular repair  4) Nitric Oxide (increases blood flow) Mitochondria have a substance called the cytochrome oxidase that can absorb red and near infrared light and convert the enregy into a form of bilogical energy called ATP.  Part of what ATP does is lead to healing and tissue repair. The process - among other things- generates a mild level oxidant (ROS) which acts as a signaling molecule to activate transcription factors that lead to tissue repair. Some people see this as a "redox" signaling molecule. Herein is where the physical healing can be accelerated when photonic therapies (red and near infrared light) is introduces. Another important player is Nitric oxide (NO) - if it sits in the cell it "clogs" the respiratory chain that leads to ATP production. PBM frees the NO back into the body and restors the function fo the respiratory chain. Then it takes on an impotant wide ranging role of improving nerve function and improving circulation by relaxing the blood vessel walls. Dr Berman explains how he connected Neurofeedback and PBM in the development of a comprehensive treatment model. He explains the use of light frequency of 1060-1080nm. For those not involved in research is there any risk or benefit in doing Neurofeedback with a particular doctor and trying out a Vielight (one PBM device) on their own. contact Dr Berman directly. Learn more about Dr Berman's work with the QuietMIND Foundation http://www.quietmindfdn.org/

This lesson explores the first two steps of the citric acid cycle and explains how the rate of ATP production is regulated according to the abilities of the electron transport chain. Together with lesson five, it explains how cells regulate their ATP production according to their needs and abilities. In the course of exploring this theme, we examine the role of reactive oxygen species in diabetes. Watch the full lesson at chrismasterjohnphd.com/mwm/2/4 Sign up for MWM Pro for early access to content, enhanced keyword searching, self-pacing tools, downloadable audio and transcripts, a rich array of hyperlinked further reading suggestions, and a community with a forum for each lesson.

Anna Briker presents her project, “Toward Assessing the Effects of Reactive Oxygen Species on Nrf2/ARE Activation by Electrophiles: Evaluating and Addressing Assay Variability,” for the 2017 Falvey Scholars Awards.

Anna Briker presents her project, “Toward Assessing the Effects of Reactive Oxygen Species on Nrf2/ARE Activation by Electrophiles: Evaluating and Addressing Assay Variability,” for the 2017 Falvey Scholars Awards.

Ivan Bogeski explains how redox-insensitive ORAI calcium channels enable monocytes to sustain calcium signaling while still producing bactericidal reactive oxygen species.

Jim Casanova describes how a macrophage adhesion receptor both mediates phagocytosis of bacteria and triggers the generation of reactive oxygen species to kill them.

Scott Earley explains how reactive oxygen species activate TRPA1 ion channels to trigger dilation of cerebral arteries.

Nancy Hynes talks about how a copper-binding enzyme called Memo promotes breast cancer metastasis.

Peixin Yang and Albert Reece discuss the critical role a proapoptotic kinase plays in the development of neural tube defects associated with maternal hyperglycemia.

Drugs that reduce microtubule density or prevent the production of reactive oxygen species in skeletal muscle might slow the progression of Duchenne muscular dystrophy.

Link to bioRxiv paper: http://biorxiv.org/cgi/content/short/2020.04.20.051904v1?rss=1 Authors: Doser, R. L., Amberg, G. C., Hoerndli, F. J. Abstract: The AMPA subtype of synaptic glutamate receptors (AMPARs) play an essential role in cognition. Their function, numbers and change at synapses during synaptic plasticity, is tightly regulated by neuronal activity. Although we know that long-distance transport of AMPARs is essential for this regulation, we do not understand the regulatory mechanisms of it. Neuronal transmission is a metabolically demanding process in which ATP consumption and production are tightly coupled and regulated. Aerobic ATP synthesis unavoidably produces reactive oxygen species (ROS), such as hydrogen peroxide, which are known modulators of calcium signaling. Although a role for calcium signaling in AMPAR transport has been described, there is little understanding of the mechanisms involved and no known link to physiological ROS signaling. Here, using real-time in vivo imaging of AMPAR transport in the intact C. elegans nervous system, we demonstrate that long-distance synaptic AMPAR transport is bidirectionally regulated by calcium influx and activation of calcium/calmodulin-dependent protein kinase II. Quantifying in vivo calcium dynamics revealed that modest, physiological increases in ROS decrease calcium transients in C. elegans glutamatergic neurons. By combining genetic and pharmacological manipulation of ROS levels and calcium influx, we reveal a mechanism in which physiological increases in ROS cause a decrease in synaptic AMPAR transport and delivery by modulating activity-dependent calcium signaling. Taken together, our results identify a novel role for oxidant signaling in the regulation of synaptic AMPAR transport and delivery, which in turn could be critical for coupling the metabolic demands of neuronal activity with excitatory neurotransmission. Copy rights belong to original authors. Visit the link for more info