Podcasts about Sonata

No Café Brasil 987 – Sonata para um homem bom, uma despedida carregada de silêncio, memória e reflexão. A morte de um confrade expõe o quanto a política invadiu até os espaços sagrados da vida. Neste episódio, Luciano Pires fala de cansaço, empatia perdida, ideologia sufocante e da urgência de resgatar o humano. Um chamado à pausa, à escuta e à recuperação do essencial. Porque ainda há sonatas que merecem ser ouvidas. O comentário do ouvinte é patrocinado pela Vinho 24 Horas. Já pensou em ter um negócio que funciona 24h, sem precisar de funcionários? Uma adega autônoma instalada no seu condomínio, com vinhos de qualidade, controle pelo celular e margem de 80%. Com apenas R$ 29.900, você inicia sua franquia e ainda ganha 100 garrafas de vinho. Acesse Vinho24.com.br e comece seu novo negócio! A Terra Desenvolvimento revoluciona a gestão agropecuária com métodos exclusivos e tecnologia inovadora, oferecendo acesso em tempo real aos dados da sua fazenda para estratégias eficientes. A equipe atua diretamente na execução, garantindo resultados. Para investidores, orienta na escolha das melhores atividades no agro. Com 25 anos de experiência, transforma propriedades em empreendimentos lucrativos e sustentáveis. Conheça mais em terradesenvolvimento.com.br. Inteligência a serviço do agro! ...................................................................................................................................................................

Beethoven once wrote to his publisher: “What is difficult, is also beautiful, good, great, and so forth. Hence everyone will realize that this is the most lavish praise that can be bestowed, since what is difficult makes one sweat.” If this credo manifests itself most powerfully in any one of Beethoven's works, it might be the piece we'll talk about today, the piano Sonata Op. 106, nicknamed, “Hammerklavier.”  It is the longest Sonata Beethoven ever wrote, which essentially means that it was the longest sonata anyone had written up to that point. It marks one of the pivot points between Beethoven's so-called heroic period and his late period, where his music became even more cosmically beautiful than before. It is certainly his most ambitious Sonata to that point, and his most difficult. The scale of the Hammerklavier sonata is hard to describe; in around 45 minutes of music, Beethoven explores the full gamut of human emotion. The intensity, the difficulty, and the concentration that this sonata requires from the pianist and listener alike has led to many people, as the pianist Andras Schiff says, to “respect and revere this Sonata, but not love it.” Most of the articles and analyses of this sonata that I found in researching this show emphasize its difficulty, its scale, its obsessiveness, and its impenetrability. But I must say that when I talk to musicians abut this piece, their eyes light up. Yes, this sonata is difficult, but what have we just learned from Beethoven? What is difficult is also beautiful, good, great and so forth. Join us as we begin a two part exploration of this remarkable work together.  Thank you to Jerry for sponsoring this show on Patreon! Recording: https://youtu.be/yBtJF_4msqw?si=bIznKSGuRyXDbFaT    

Jan Dismas Zelenka (1679-1745) - Sonata in sib maggiore per violino, oboe fagotto e b.c. ZWV 181/31.       Adagio [00:00]2.       Allegro [03:30]3.       Largo [07:48]4.       Allegro - Tempo giusto [10:56] Syntagma AmiciJérémie Papasergio, fagottoElsa Frank, oboeStéphanie De Failly, violinoGuy Penson, clavicembaloBernard Woltèche, violoncello

Diviértete, aprende y conoce nuevos e interesantes temas en nuestro programa ¡HIBRIDO! Transmitido todos los Jueves en punto de las 21:00 hrs. Con tu locutor favorito Israel Garcia, hoy platicamos sobre: Sonata de otoño & adivinación y arte

fWotD Episode 2980: Saxophone Sonata (Creston) Welcome to Featured Wiki of the Day, your daily dose of knowledge from Wikipedia's finest articles.The featured article for Wednesday, 2 July 2025, is Saxophone Sonata (Creston).The Sonata for E♭ Alto Saxophone and Piano, Op. 19, was composed by Paul Creston in 1939. The sonata was commissioned in the spring by Creston's frequent collaborator, the American saxophonist Cecil Leeson. Creston began composition by June: it was completed by the end of August and slated for publication in 1940, although this was postponed to 1945 due to World War II. The sonata is in three movements and takes around thirteen minutes to perform. Its form follows a traditional, classical-era structure. The first movement is in a modified sonata form with no recapitulation: two themes are introduced in an exposition and extensively developed, before the movement ends with a coda. Harmonically, it is based on seventh chords, with its tonality moving between several tonal centers. A slower middle movement with song-like melodies follows, before the sonata ends with a rhythmically complex rondo featuring polymeters. The sonata as a whole is of considerable difficulty for both players.Creston and Leeson premiered the sonata at the Carnegie Chamber Hall on February 15, 1940, although Leeson had performed it on tour prior to that date. No critics were present at the premiere, but the sonata's 1955 debut recording by Vincent Abato and Creston obtained a mixed response. Most found the sonata enjoyable, but there was criticism of a perceived simplistic and salon-like styling. It was the first of Creston's chamber works to be recorded and had appeared on fourteen records by 1980. Today, it is broadly seen as a key piece of the classical saxophone's repertoire and is frequently performed.This recording reflects the Wikipedia text as of 00:40 UTC on Wednesday, 2 July 2025.For the full current version of the article, see Saxophone Sonata (Creston) on Wikipedia.This podcast uses content from Wikipedia under the Creative Commons Attribution-ShareAlike License.Visit our archives at wikioftheday.com and subscribe to stay updated on new episodes.Follow us on Mastodon at @wikioftheday@masto.ai.Also check out Curmudgeon's Corner, a current events podcast.Until next time, I'm generative Ayanda.

In Biber's time, harmony was something cosmic, vibrating in a God-given resonance between human, instrumental, and celestial bodies. After all, the string instrument in early modern Europe was configured as a human body – with a neck, belly, and ribs to match. The Sonatas were therefore not only designed to delight, but also potentially to balm and heal; Biber described the sonatas as a kind of prayer for his patron's longevity and good health.

Francis Jean Marcel Poulenc (1899 – 1963) - Sonata per clarinetto e pianoforte FP1841.       Allegro tristamente (Allegretto - Très calme - Tempo allegretto)2.       Romanza (Très calme)3.       Allegro con fuoco (Très animé) Karl Leister, clarinettoJames Levine, pianoforte

Gioachino Rossini (1792-1868) – Sonata a quattro n. 3 in do maggiore per due violini, violoncello e contrabasso1.       Allegro2.       Andante3.       ModeratoBaiba Skride – violinoAndrés Gabetta – violinoMonika Leskovar – violoncelloRoberto di Ronza – contrabasso

Avui sentirem: Sonata per a viol

  NEW SUBSCRIPTION INTERFACE DOOHICKY!   You can now find our subscription page at GeorgeHrab.com at this link. Many thanks to the majestic Evo Terra for his assistance.   THE SHOW NOTES  The “Proof” of Blessings Intro Predator: Killer of Killers Interesting Fauna      - Feather-legged lace weaver (Uloborus plumipes) Phombast Series-8 Replicandor Scrim Manual Ask George      - Etude, Prelude, Nocturne, Sonata,        Minuet, & Suite? from Robert D. The Man In Love With You Religious Moron of the Week      - The Taliban from Mike Molnar Tell Me Something Good      - Vatican Now 100% Solar Show Close .........................   MENTIONED IN THE SHOW  Feather-legged lace weaver  .........................   EVENTS ON THE SCHEDULE  FRIDAY, JULY 25th 9:00- 11:00 The George HraBand OUTDOOR CONCERT HBS Community Stage at Steel Stacks, Bethlehem PA FREE! MUSIKFEST: SUNDAY, AUGUST 3, 2025 5:00 - 5:45 George Hrab: Solo Acoustic LYRICPLATZ STAGE  (Frank Banko Cinemas) Bethlehem, PA FREE! MUSIKFEST: TUESDAY, AUGUST 5, 2025 6:00 - 6:30 pm George Hrab: Solo Acoustic LAGERPLATZ STAGE Bethlehem, PA FREE! MUSIKFEST: THURSDAY, AUGUST 7, 2025 9:00 – 11:00 pm The George HraBand LIEDERPLATZ STAGE  (Sun Inn Courtyard) Bethlehem, PA FREE! .........................   Get George's Music Here  https://georgehrab.hearnow.com https://georgehrab.bandcamp.com ................................... SUBSCRIBE! You can sign up at GeorgeHrab.com and become a Geologist or a Geographer. As always, thank you so much for your support! You make the ship go. ................................... Sign up for the mailing list: Write to Geo! Check out Geo's wiki page, thanks to Tim Farley. Have a comment on the show, a Religious Moron tip, or a question for Ask George? Drop George a line and write to Geo's Mom, too!

Louis XIV is dead, and his heir is a 5-year-old child. With so many deaths occurring in the royal family, it falls to an unlikely royal nephew, Philippe, duke of Orléans, to govern France until Louis XV comes of age. Completely unlike the callous old Sun King, Philippe is a man of the people who spurned Versailles and lived as a boisterous libertine. What kind of regent will this man be? ⚜️ Visit our Wordpress for episode images, score summaries, contact details and more! Contact us by Email, or follow us on Instagram, our Facebook Group or BlueSky. Make sure you leave us a review on Apple Podcasts, Spotify or wherever you listen. You can also support the show on Patreon! Join the official Angry Mob and get access to our bonus content: movie reviews, deep dives, bonus biographies and our exclusive spinoff series rating the Royal Mistresses. ⚜️ Battle Royale's intro/outro music is "Dansez" by Fasion. Other music used for this episode: "Sonata for cello and Continuo in B flat, RV.47 - 1. Largo" by Antonio Vivaldi, performed by Christophe Coin, Ageet Zweistra and Christopher Hogwood. ℗ 1987 Decca Music Group Limited ⚜️ CATEGORIES Ben and Eliza each give a score out of 10 for the first 4 categories. The 5th is determined by maths! The result is a total score out of 100. 1. Enchanté: The shallow, first-impressions round: How fabulous and iconic an image have they passed down to us? 2. En Garde: (A.K.A. “Selfish Wins”) How well did they gain and increase their personal power, either through scheming, statesmanship or good old fashion battles? 3. Voulez-Vous: (A.K.A. “Selfless Wins”) How much would we want to live under their regime? How well did they better the world around them through law reforms and cultural projects? 4. Ouh-Là-Là: How pearl-clutchingly scandalous were the events of their life, both in their time and down through the ages? How mad, bad and dangerous were they to know? 5. La Vie en Throne: How many years did they reign, and how many of their children survived them? For more details on the scores, how they are calculated and how our kings are ranking, visit our website. Learn more about your ad choices. Visit megaphone.fm/adchoices

Old friends reunite in full bloom beneath the earth's crust, as Gaea Defaced resurfaces once again. Our heroes recuperate and venture back out to find relics of a long lost age, will they succeed or face the music? Find out on this episode of The Forever DMs! Hosted on Acast. See acast.com/privacy for more information.

My conversation with Matthew Walker, PhD on faculty at UC Berkeley where he is a professor of neuroscience and psychology, the founder and director of the Center for Human Sleep Science, and has a long history of seminal contributions on sleep science and health. Audio File (also downloadable at Apple Podcast and Spotify)“Sleep is a non-negotiablebiological state required for the maintenance of human life . . . our needsfor sleep parallel those for air, food, and water.”—Grandner and FernandezEric Topol (00:07):Hello, it's Eric Topol with Ground Truths, and I am really delighted to welcome Matt Walker, who I believe has had more impact on sleep health than anyone I know. It's reflected by the fact that he is a Professor at UC Berkeley, heads up the center that he originated for Human Sleep Science. He wrote a remarkable book back in 2017, Why We Sleep, and also we'll link to that as well as the TED Talk of 2019. Sleep is Your Superpower with 24 million views. That's a lot of views here.Matt Walker:Striking, isn't it?Eric Topol:Wow. I think does reflect the kind of impact, you were onto the sleep story sooner, earlier than anyone I know. And what I wanted to do today was get to the updates because you taught us a lot back then and a lot of things have been happening in these years since. You're on it, of course, I think you have a podcast Sleep Diplomat, and you're obviously continued working on the science of sleep. But maybe the first thing I'd ask you about is in the last few years, what do you think has been, are there been any real changes or breakthroughs in the field?What Is New?Matt Walker (01:27):Yeah, I think there has been changes, and maybe we'll speak about one of them, which is the emergence of this brain cleansing system called the glymphatic system, but spreading that aside for potential future discussion. I would say that there are maybe at least two fascinating areas. The first is the broader impact of sleep on much more complex human social interactions. We think of sleep at maybe the level of the cell or systems or whole scale biology or even the entire organism. We forget that a lack of sleep, or at least the evidence suggests a lack of sleep will dislocate each other, one from the other. And there's been some great work by Dr. Eti Ben Simon for example, demonstrating that when you are sleep deprived, you become more asocial. So you basically become socially repellent. You want to withdraw, you become lonely. And what's also fascinating is that other people, even they don't know that you sleep deprived, they rate you as being less socially sort of attractive to engage with.Matt Walker (02:35):And after interacting with you, the sleep deprived individual, even though they don't know you're sleep deprived, they themselves walk away feeling more lonely themselves. So there is a social loneliness contagion that happens that a sleep deprived lonely individual can have almost a viral knock on effect that causes loneliness in another well-rested individual. And then that work spanned out and it started to demonstrate that another impact of a lack of sleep socially is that we stop wanting to help other people. And you think, well, helping behavior that's not really very impactful. Try to tell me of any major civilization that has not risen up through human cooperation and helping. There just isn't one. Human cooperative behavior is one of our innate traits as homo sapiens. And what they discovered is that when you are insufficiently slept, firstly, you don't wish to help other people. And you can see that at the individual level.Matt Walker (03:41):You can see it in groups. And then there was a great study again by Dr. Eti Ben Simon that demonstrated this at a national level because what she did was she looked at this wonderful manipulation of one hour of sleep that happens twice a year to 1.6 billion people. It's called daylight savings time at spring. Yeah, when you lose one hour of sleep opportunity. She looked at donations across the nation and sure enough, there was this big dent in donation giving in the sleepy Monday and Tuesday after the clock change. Because of that sleep, we become less willing to empathetically and selflessly help other individuals. And so, to me I think it's just a fascinating area. And then the other area I think is great, and I'm sorry I'm racing forward because I get so excited. But this work now looking at what we call genetic short sleepers and sort of idiots like me have been out there touting the importance of somewhere between seven to nine hours of sleep.Matt Walker (04:48):And once you get less than that, and we'll perhaps speak about that, you can see biological changes. But there is a subset of individuals who, and we've identified at least two different genes. One of them is what we call the DEC2 gene. And it seems to allow individuals to sleep about five hours, maybe even a little bit less and show no impairment whatsoever. Now we haven't tracked these individuals across the lifespan to truly understand does it lead to a higher mortality risk. But so far, they don't implode like you perhaps or I would do when you are limited to this anemic diet of five hours of sleep. They hang in there just fine. And I think philosophically what that tells me, and by the way, for people who are listening thinking, gosh, I think I'm probably one of those people. Statistically, I think you are more likely to be struck by lightning in your lifetime than you are to have the DEC2 gene. Think about what tells us, Eric. It tells us that there is a moment in biology in the evolution of this thing called the sleep physiological need that has changed such that mother nature has found a genetic way to ZIP file sleep.Matt Walker (06:14):You can essentially compress sleep from seven to nine hour need, down to five to six hour need. To me, that is absolutely fascinating. So now the race is on, what are the mechanisms that control this? How do we understand them? I'm sure much to my chagrin, society would like to then say, okay, is there a pill that I can take to basically ZIP file my own sleep and then it becomes an arms race in my mind, which is then all of a sudden six hours becomes the new eight hours and then everyone is saying, well, six hours is my need. Well I'll go to four hours and then it's this arms race of de-escalation of sleep. Anyway, I'm going on and on, does that help give you a sense of two of the what I feel the more fascinating areas?Eric Topol (07:01):Absolutely. When I saw the other recent report on the short sleep gene variant and thought about what the potential of that would be with respect to potential drug development or could you imagine genome editing early in life that you don't need any sleep? I mean crazy stuff.Matt Walker (07:19):It was amazing.Glymphatics and Deep Sleepfor more, see previous Ground Truths on this topic Eric Topol (07:22):No, the mechanism of course we have to work out and also what you mentioned regarding the social and the behavior engagement, all that sort of thing, it was just fascinating stuff. Now we touched on one thing early on to come back to the glymphatics these channels to get rid of the waste metabolites from the brain each night that might be considered toxic metabolites. We've learned a lot about those and of course there's some controversy about it. What are your thoughts?Matt Walker (07:55):Yeah, I think there's really quite comprehensive evidence suggesting that the brain has this cleansing system like the body has one the lymphatic system, the brain has one the glymphatic system named after these glial cells that make it up. And I think there's been evidence from multiple groups across multiple different species types, from mouse models all the way up to human models suggesting that there is a state dependent control of the brain cleansing system, which is a fancy way of saying if you are awake in light NREM, deep NREM or perhaps you're just quiet and you are resting in your wakefulness, the glymphatic system is not switched on at the same rate across all of those different brain states. And I think the overwhelming evidence so far using different techniques in different species from different groups is that sleep is a preferential time. It's not an exclusive time, it's a preferential time when that brain cleansing system kicks into gear because as some people have, I think argued, and you could say it's hyperbolic, but wakefulness is low level from a biochemicals perspective, it's low level brain damage and sleep is therefore your sanitary salvation that combat that biochemical cascade.Matt Walker (09:15):So in other words, a better way of putting it would be, sleep is the price that you pay for wakefulness in some ways. And I think there was a recent controversial study that came out in 2022 or 2023, and they actually suggested quite the opposite. They said using their specific imaging methods, they found that the sort of clearance, the amount of cerebral spinal fluid, which is what washes through the brain to cleanse the toxins, the rate of that flow of cerebral spinal fluid was highest during wakefulness and lowest during deep NREM sleep, the exact opposite of what others have found. Now, I think the defendants of the glymphatic sleep dependent hypothesis pushed back and said, well, if you look at the imaging methods. Firstly, they're nonstandard. Secondly, they were measuring the cerebral spinal flow in an artificial way because they were actually perfusing solutions through the brain rather than naturally letting it flow and therefore the artificial forcing of fluid changed the prototypical result you would get.Matt Walker (10:27):And they also argued that the essentially kind of the sampling rate, so how quickly are you taking snapshots of the cerebral spinal fluid flow. Those were different and they were probably missing some of the sleep dependent slow oscillations that seemed to sort of drive that pulsatile flow. Honestly, I think that paper was still very well done, and I still think there is right now, I would still cleave to the majority of overwhelming evidence considering it's not just from one group in one species, but across multiple species, multiple groups. And I think it's nevertheless a weight of burden that has pushed back. And my sense right now, I used to think and cleaves to the notion that it was a sleep expressly selective process. Now I don't think that that's the case anymore. I think that the glymphatic system is a dynamic system, but it's always looking for the opportunity to go into cleansing mode. And you can kind of go into almost like a low battery mode when you are awake, but in quiet rest. And I think that can drive some already early clearance from the brain and then when you go into sleep, it's like powering your phone off entirely. It truly gets the chance to cleanse and reboot the biochemical system. But I think it's really interesting. I think there's a lot of work still yet to be done. It's not quite as case closed as we used to think.Eric Topol (12:03):Yeah, I mean first of all, it's great that you straighten out the controversy because that's exactly what I was referring to. And secondly, as you also pointed out, the weight of the evidence is that it's a sleep dependent phenomena, particularly during flow wave deep sleep is at least what I've seen.Matt Walker (12:21):Yes.Eric Topol (12:22):What's also interesting, your point about it being dynamic, which fascinating, there was a paper in my field of cardiology, people with atrial fibrillation had less active glymphatic, less clearance which was really interesting. And then the other finding that's also noteworthy was that Ambien made things worse. What do you think about that?We Are An Embodied OrganismMatt Walker (12:45):I think it's really interesting, and just to come back to your point about the AFib paper, what we know is that this cleansing system in the brain does seem to track the big slow brainwaves of deep slow wave sleep, but it's not only tracking the big slow brainwaves. If anything, there's something to do with the cardiorespiratory cycle, the respiration rate and the cardiac signal that may actually sink with the brainwaves. And it's essentially a cardiorespiratory neurophysiological coupling, which is a lot of ways, which is to say heart, lungs and brain coupled together. And it's the coupling of the cardiorespiratory slow oscillations that drive these pulsatile fluid mechanical, it's literally a hydro mechanical, hydro meaning cerebral spinal fluid push and pull in and out of the system drawing those metabolites out. So ago, if you have a disrupted either cardiac or respiratory or neurophysiological signal, no wonder the glymphatic system isn't going to work as efficiently.Matt Walker (14:00):I think that's a beautiful demonstration of the hemineglect that people like me who study sleep largely from the neck upwards would miss. But if you think about sleep is not just for the brain, it's for the body and it's not just for the body, it's for the brain. And we're an embodied organism. We study the organism in silos, neurology, psychiatry, cardiology, respiratory, but they all interact. And so, I think what's lovely about your example is the reminder that if you don't study the body in this study of the glymphatic system, you could miss out a profound explanation that possibly accounts for the head scratching, I don't know why we're getting this result. So that's a long way to come back to it. But the same group that was the pioneer in the discovery of the glymphatic system led by Maiken Nedergaard at the University of Rochester.In SUPER AGERS, p. 57. SRI-sleep regulatory indexSleep MedicationsMatt Walker (15:01):She has gone on to then look to say, well, if this is a sleep dependent process of brain cleansing during deep sleep, what about sleeping pills because so many people are either taking or are addicted to sleeping pills. And we've gone through, we're in the era of web 3.0 with sleeping pills, we started off web 1.0 which were the benzos, the kind of temazepam, diazepam, lorazepam. Then we went to web 2.0, which was sort of the Ambien (zolpidem), Lunesta, Sonata. And what was common about those two classes of drugs is that they both went after something called the GABA receptor in the brain, which is this major inhibitory receptor in the brain. And essentially, they were called sedative hypnotics because they sedated your cortex. And when you take an Ambien and not going to argue you're awake. You're clearly not awake, but to argue you're a naturalistic sleep, if you look at this, physiology is an equal fallacy.Matt Walker (16:01):They made this interesting experimental hypothesis that when you take Ambien, you sleep longer and based on how you score deep sleep, it would seem as though Ambien increases the amount of minutes that you spend in deep sleep. But if you look at the electrical signature during that “increased deep sleep” it's not the same. Ambien takes a big bite. There's a big dent out of the very slowest of the slow brainwaves, and it's the slowest of the slow brainwaves that drive the glymphatic system. So what they found was that when you take Ambien or you give mice Ambien. Yes, they sleep longer, they seem to have more deep sleep, but the brain cleansing mechanism seem to be reduced by anywhere between 30-40%, which is counterintuitive. If you are sleeping more and you're getting more deep sleep and the glymphatic system is active during deep sleep, you should get greater cleansing of the brain.Matt Walker (17:05):Here they found, yes, the drug increased sleep, particularly deep sleep, but it empowered the cleansing of the brain system. Now, have we got evidence of that in humans yet? No, we don't. I don't think it's far away though, because there was a counter study that brings us onto web 3.0. There's a new class of sleep medications. It's the first class of medications that have actually been publicly advocating for, they're called the DORAs drugs, and they are a class of drugs and there's three of them that are FDA approved right now. DORA stands for dual orexin receptor antagonists, which means that these drugs go in there and they block the action of a chemical called orexin. What is orexin? Orexin is the volume button for wakefulness. It dials at wakefulness, but these drugs come into your system and unlike the sedative sort of baseball bat to the cortex, which is Ambien, these drugs are much more elegant.Matt Walker (18:11):They go down towards the brainstem and they just dial down the volume on wakefulness and then they step back, and they allow the antithesis of wakefulness to come in its place, which is this thing called naturalistic sleep. And people sleep longer. So as a scientist, you and I perhaps skeptics would then say, well, so you increase sleep, and I have four words for you. Yes, and so what. Just because you increase sleep, it doesn't mean that it's functional sleep. It could just be like the old notion of junk DNA, that it's epiphenomenal sleep. It's not functional sleep. There was a study out of WashU and they took 85-year olds and above and they gave them one of these DORAs drugs. It's a drug called Belsomra, it's a play on good sleep or beautiful sleep, chemical named suvorexant and randomized placebo control. What they found is that when they took the drug, yes, these older adults slept longer, they had more deep sleep, but then what they did was clever. Before and after the night of sleep, they drew blood because we can now measure markers of β-amyloid and tau protein circulating in the bloodstream, which are these two markers of Alzheimer's disease.Matt Walker (19:28):Why is that relevant to the glymphatic system? It's relevant because two of the pieces of metabolic detritus that the cleansing system washes away at night, β-amyloid and tau. I'm sure enough of what they found was that not only did the adults sleep longer with these sleeping medications, they also had a greater clearance of β-amyloid and tau within the bloodstream. So this was the exact opposite of the Ambien study, which was where they were seeing an impairment in the glymphatic activity. Here in humans was a study with the web 3.0 sleep medications. Suvorexant, not only did it increase sleep, but it seemed to increase. Well, the assumption was that it was increasing glymphatic clearance because at least as the end outcome product, there was greater clearance of β-amyloid and tau protein in the blood. It wasn't just junk sleep, it was functional sleep. So for the first time I'd seen a sleeping medication that increased sleep more naturalistically, but that increased sleep made you the organism function better the next day as a consequence. Does that make any sense?Eric Topol (20:38):Absolutely. And it's interesting that we may have a sleep medicine finally or a class that actually is doing what is desired. This is one of the other things I was going to ask you about is that as you pointed out, this is an interaction throughout the organism, throughout the human being, and we've seen studies about how sleep disrupts metabolism and through that of course, and even separately, can take down our immune system or disrupt that as well. And so, one of the questions I guess is your thoughts about these other effects because you mentioned of course the potential of looking at things like p-Tau217 markers or other markers that would denote the status of your ultimate risk for moving on to Alzheimer's disease. But there's these other factors that also play a role with lack of adequate sleep and perhaps particularly sleep quality. I wonder if you could just comment about this because there's so many different systems of the body that are integrated here, and so the sanitary effect that you just described with the ability to potentially see less, at least biomarkers for what would be considered risks to ultimately develop Alzheimer's, there's also these other very important effects when we talk about high quality sleep, I guess, right? And maybe you could comment about that.Matt Walker (22:21):Yeah, I think quantity is what we've been talking about in some ways, but quality has also come onto the radar as absolutely essential. And what we find is that the quality of your sleep is as if not more predictive of both all-cause mortality, cardiovascular mortality, metabolic mortality, and in some regards, cancer mortality as well. And when I say quality of sleep, what we're really referring to here is at least one of two things. One is the continuity of your sleep. So you could be sleeping for eight and a half hours according to your sleep tracker, but maybe you are getting eight and a half hours by spending ten hours of time in bed because you are awake so much throughout the night and your sleep is very sort of punctured and littered with all of these awakenings across the night. That's sufficient quantity of sleep eight and a half hours, but it's poor quality of sleep because you are spending too much time awake.Matt Walker (23:30):And so, our measure of quality of sleep typically is what we call sleep efficiency. Of the time that you are in bed, what percent of that time are you asleep? And we like to see some measure of at least 85% or above because once you get less than 85% in terms of your sleep quality or your sleep efficiency, then you start to see many of these unfolding system-wide impairments. You seem to have high risk of diabetes, high risk obesity, high risk, as we said, cardiovascular disease. Also, hormonal changes both in men and in women. We see upstairs in the brain with poor quality of sleep, much more so than quantity of sleep. Poor quality of sleep is a more powerful predictor of mood disturbances and psychiatric conditions. And in fact, I think if you look at the data, at least in my center in the past 23 years, we've not been able to discover a single psychiatric condition in which sleep is normal, which to me is a stunning revelation. And what that tells us is that in many of those conditions they do seem to be getting not too bad of quantity of sleep. What is the marker of psychiatric sleep disturbance is not short quantity, it's poor quality of sleep. So I think it's a wonderful important point that I don't think we pay enough attention to, which is the quality.Eric Topol (25:05):Yes. And the other thing that you've emphasized, and I just want to reiterate to people listening or watching that is the regularity story, just like you said with quality. The data and I'll put the figure in that shows the link between regularity and cardiovascular, neurodegenerative, cancer, that regularity thing. A lot of people don't understand how important that is as well.Matt Walker (25:30):Stunning study from data from the UK Biobank, and this is across thousands and thousands of individuals and they tracked quantity and they tracked regularity and they split people up into the quartiles, those who were most regular and those who were least regular. And as you'll see in those sort of the figure that you flash up, those people who were in the upper quartile of regularity, de-risk all-cause mortality, cancer mortality, cardiovascular mortality, it was stunning. And then they did a cute little experiment of a statistical test where they took quantity because they had it in these individuals and regularity and they kind of put them in the same statistical bucket and did a sort of a Coke Pepsi challenge to see which one won out. And what it seemed to be was that regularity almost beat out quantity in terms of predicting all-cause mortality. Now that's not to say that you can get away with saying, well, I sleep four hours a night, but I sleep very regularly, consistently four hours a night. No, you need both, but regularity. I was someone who based on my remarkably vanilla and pedestrian personality, I've always been quite regular in my regard. But goodness me, even when I read that paper, I thought I'm doubling down on regularity. It's so important. That tells us, I think something that is in some ways a story not about sleep. It's a story about your circadian rhythm.Matt Walker (27:02):We speak a lot, or I speak a lot about sleep, and I think I've probably done a mis service to the other aspect of the sleep wake rhythmicity, which is called your 24 hours circadian rhythm. Now your sleep pressure, the drive to sleep is independent of your circadian rhythm, but they often work beautifully in harmony with each other, and you fall asleep, and you stay asleep. But I think the circadian system is critical because, excuse me, and what the circadian rhythm also regulates, sneezing right at the inopportune moment when you are recording a podcast. But nevertheless, what that tells me is that when you feed your brain signals of wake sleep consistency, which is to say wake, sleep, timing, regularity, there is something about feeding the brain signals of regularity that anchor your 24-hour circadian rhythm and as a consequence, it improves the quantity and the quality of your sleep. They're intertwined.What About Sleep Trackers?Eric Topol (28:09):That's a terrific explanation for what I think a lot of people don't appreciate it's importance. Now, last topic about tracking. Now we understand how important sleep is. It is the superpower I am with you on that really brought that to light in so many ways. But of course, now we can track it with rings with smart watches and we get these readouts things like efficiency as part of the Oura score and other rings and deep sleep or NREM, REM, the works, you can see your awake times that you didn't know you're awake and the whole bit. Do you recommend for people that aren't getting great sleep quality beyond that they should try to establish a regular schedule that they should track to try to improve it and of course how would they improve it? Or are these things like having a cold mattress temperature that is controlled? What are the tricks that you would suggest for trying to improve your sleep through tracking? Or do you think tracking shouldn't be done?Matt Walker (29:16):Oh gosh, it's such a wonderful question and as with wonderful questions, the answer is usually it's complicated and I have to be careful because for someone who's currently wearing three different sleep trackers, it's going to be hard for me to answer this question completely in the negative. And there are three different sleep trackers. But I would say that for the most part, I like the idea of sleep tracking if you are sleeping well, meaning if as long as you're not suffering from insomnia. The reason is because sleep unlike those two other critical of health, which is diet and exercise, is very difficult to subjectively estimate. So if I were to ask you, Eric, how many times have you worked out in the past week, you'd be able to tell me how cleanly or how poorly have you been eating in the past week. You could tell me.Matt Walker (30:09):But if I was to say to you, Eric, how much deep sleep did you get last Tuesday? And if you don't have a sleep tracker, you'd say, I don't know. And so, there's something useful about tracking, especially a non-conscious process that I think is meaningful to many. And often medicine we say what gets measured gets managed, and there is that trite sort of statement. I do think that that's still true for sleep. So many people I've spoken to have, for example, markedly reduced the amount of alcohol consumption because they've been seeing the huge impact that the alcohol consumption in the evening has on their ring smart ring data as a consequence. So overall, I think they're pretty good. When people ask me what's the best sleep tracker, I usually say it's the one that you wear most frequently because if I come up with a band, headband, chest straps, all sorts of different things and it's a hundred percent accurate, but after three uses of it, you stop using it, that's a useless sleep tracker. So I like to think about sleep trackers that are low friction and no friction. When we go to sleep, we take things off, we don't put things on. That's why I liked things like the ring. For example, I think that's a non-intrusive way. I think the mattress may be as if not better because it's a completely friction less device. You don't have to remember to charge it. You don't have to put it on, you just fall into bed, and it tracks your sleep.Matt Walker (31:40):One form factor, I like to think about sleep trackers is the form factor itself. But then the other is accuracy. And I think right now if you look at the data, probably Oura is winning the ring kind of wars. If you look at all wristband wars, I think it's probably the most accurate relative to something like Fitbit or Apple Watch or the Whoop Band. But they're all pretty close. I think Oura is probably the leader in class right now at least. Keep in mind that I used to be an advisor for Oura. I want to make that very clear. So take what I say with a grain of salt in that regard. I think to your question, well, I'll come back to mattresses in just one second.Matt Walker (32:34):For people who are struggling with sleep, I think you've got to be very, very careful with sleep trackers because they can have the counterproductive effect where I gave you the example of alcohol or eating too late. And these sleep trackers help you modify your behaviors to improve your sleep. Well, there are places where these trackers can actually do you a disservice. When you get so hyper focused on your data and your data not looking good each and every day, it becomes a self-fulfilling prophecy of a negative spiral. And we now have a condition in sleep medicine called orthosomnia. So ortho in medicine typically means straightened. So you've heard of orthodontic straightening teeth, orthopedic straightening bones, orthosomnia is about getting so obsessed with getting your sleep perfect and your sleep straight that it causes an insomnia like syndrome. Now, I don't know, I think the press has made more of this than there is.Matt Walker (33:30):It probably is about 5-7% of the population. I would say at that moment in time, do one of two things. Either take the ring off entirely and just say, I'm going to get my sea legs back underneath me, get some cognitive behavioral therapy for insomnia. And when I'm confident I'll put the ring back on. Or don't throw the baby out with the bath water, keep wearing the ring. Try to say to yourself only on let's say a Sunday afternoon, will I open up the app and look historically what's been happening during the past week so that you keep getting your data, but you don't get the angiogenic daily sort of repetition of reinforcement of I'm not sleeping well. I should also note by the way that I think sleep trackers are not a substitute for either a sleep recording laboratory, but also, they're not a substitute for ultimately telling you entirely how good your sleep is.Matt Walker (34:24):Don't forget, you should always keep in mind how do I feel the next day? Because I think a lot of people will see their readiness score as 92 and they feel miserable. They just feel rough. And then another day, my readiness score was 62 and I just went out and I just ran my fastest five mile that I've done in the past six months. So don't forget that subjective sense of sleep is just as important as objective measures of sleep. The final thing I would say to your point about the mattresses, I actually do think that they are a really great vehicle for sleep augmentation because these smart mattresses, they're filled with sensors, things like Eight Sleep, and they will assess your physiology, they will track your sleep just like a sleep tracking ring. But what's also good is that because they can manipulate temperature and your sleep is so thermoregulatory sensitive that they create this kind, it's almost like this bent arc of thermal story throughout the night because you have to warm up at the surface to cool down at the core to fall asleep, then you have to stay cool to stay asleep, then you have to warm up to wake up and they take you through that natural change.Matt Walker (35:41):But they do it intelligently because they're measuring your sleep minute to minute. And then they're saying, I'm tweaking temperature a little bit. Has sleep improved? Has it become worse? Oh, it's become better. Let's lean into that. Let's get them even colder. Oh, wait a second, it's getting worse. Let's warm it back up a little bit. It's like a staircase method, like a Richter shock. And gradually they find your sweet spot and I think that is a really elegant system. And now they're measuring snoring. Snoring perturbations, and they can augment the bed and raise the angle of the bed up just a little bit so that the gravity doesn't have as much of a hold on your airway because when you're lying on your back, the airway wants to collapse down to gravity, and when you raise back up again, it will change that. And so, I think that there's lots of new advantages in, I think mattress technology that we'll see coming out into the future. I think it's a great vehicle for sleep augmentation.Eric Topol (36:37):That's terrific. Well, this has been for me, very educational, as I would've predicted, if anybody's up on everything in this area, it would be you. So thank you, Matt. It's a really brilliant discussion, really enlightening. We could talk some more hours, but I think we've encapsulated some of the big things. And before we finish up, is there anything else you wanted to say?Matt Walker (37:05):No, I think just to thank you for both your work in general in terms of science communication, your offer here specifically to allow me to try to be a very poorly communicated voice of sleep, and also just what you've done in general for I think the accuracy of science communication out into the public. Please never stop, continue to be a shining light for all of us. You are remarkable. Thank you, Eric.Eric Topol (37:31):Oh, you're very kind. And I look forward to the next chance we get to visit in person. It's been too long, Matt. And all the best to you. Thanks for joining today.************************************************A quick pollI cover much about sleep and healthy aging in SUPER AGERS, which has been on the NYT Bestseller list for 3 weeks. I'm very grateful to many of you for being one of the book's readers.And thanks for reading and subscribing to Ground Truths.If you found this interesting please share it!That makes the work involved in putting these together especially worthwhile.All content on Ground Truths—its newsletters, analyses, and podcasts, are free, open-access.Paid subscriptions are voluntary and all proceeds from them go to support Scripps Research. They do allow for posting comments and questions, which I do my best to respond to. Many thanks to those who have contributed—they have greatly helped fund our summer internship programs for the past two years Get full access to Ground Truths at erictopol.substack.com/subscribe

Today, SunLit editor Kevin Simpson chats with the author of a Colorado Book Awards finalist in the novel category for his story that follows a character trying to unravel the mystery behind a remarkable piece of early 20th-century music.See omnystudio.com/listener for privacy information.

Giuseppe Sammartini (1695 - 1750) - Sonata Prima in Do maggiore per violino e basso continuo1.        Andante  2.       Allegro 3:483.       Adagio 6:464.       Allegro 8:54Ensemble LuciminiaFlavia Succhiarelli, violinoAnaïs Lauwaert, viola da gambaNicola Bisotti, clavicembalo

The Trombone Corner Podcast is brought to you by Bob Reeves Brass and The Brass Ark.  Join hosts Noah and John as they interview Dr. Brittany Lasch, trombone soloist and professor at Indiana University.   About Brittany: A winner of the S&R Foundation Washington Award and Astral Artists National Auditions, trombonist Brittany Lasch brings authenticity and unshakeable commitment to all aspects of her music-making. Increasingly in demand as a soloist with orchestras and brass bands alike, Brittany balances an intensive performance career with her role as a sought-after educator and newly appointed Assistant Professor of Trombone at the renowned Jacobs School of Music at Indiana University. As a serial collaborator and commissioner of composers, Brittany is a musical explorer creating new repertoire for her instrument from some of today's most compelling voices, and true ambassador in expanding recognition for the trombone as a powerful solo voice for today. Brittany has appeared as a soloist with ensembles ranging from the U.S. Army Band “Pershing's Own”, Rodney Marsalis Philadelphia Big Brass, and for concerto performances with the Queens Symphony, National Repertory Orchestra, Bucks County Symphony, Bowling Green Philharmonia, Manhattan School of Music Philharmonia, and others across the country. With playing described as “masterful” (Syracuse Post-Standard), American Record Guide recently hailed Brittany as an "excellent soloist" across a diverse range of repertoire.  Brittany has been a featured guest artist at numerous festivals, including the International Trombone Festival, the International Women's Brass Conference, and the American Trombone Workshop. She was a winner of the National Collegiate Solo Competition hosted by the U.S. Army Band, the Eisenberg-Fried Brass Concerto Competition at the Manhattan School of Music, the Zulalian Foundation Award in Boston. Her trombone quartet Boston Based won the 2017 International Trombone Association's Quartet Competition. In 2018, Brittany was awarded 2nd place in The American Prize Solo Instrumentalist competition. A prizewinner in numerous other competitions, she received the coveted John Clark Award upon graduation from the Manhattan School of Music for outstanding accomplishment in brass performance. For six seasons, Brittany was the Principal Trombone of the Detroit Opera Orchestra at the Detroit Opera House. She has performed with orchestras nationwide, including the San Francisco Symphony, Los Angeles Philharmonic, Indianapolis Symphony, St. Louis Symphony, Detroit Symphony, Nashville Symphony, The Florida Orchestra, Toledo Symphony Orchestra, ProMusica Chamber Orchestra, Rhode Island Philharmonic, the Oregon Bach Festival Orchestra, the Vermont Symphony, Albany Symphony, Syracuse Symphony, and the New World Symphony in Miami Beach. She participated in the Verbier Festival Orchestra for two summers, and has also appeared at the Spoleto USA Festival, the Pacific Music Festival in Sapporo, Japan, the Castleton Festival, and the Aspen Music Festival. An active presence in the global trombone community, Brittany's performances for the current and past seasons include Argentina's Trombonanza, Portugal's Gravíssimo Festival, as well as appearances in Japan and Korea. As an advocate for new music, Brittany has commissioned and performed several new pieces for the trombone, including acclaimed composer Reena Esmail's major Sonata for Trombone and Piano, which she commissioned for her Astral Artists recital in Philadelphia. Brittany gave the premiere of the orchestrated version of Martin Kennedy's Theme and Variations for Trombone and Orchestra with the BGSU Philharmonia under the direction of Dr. Emily Brown. She also recorded the work with the BGSU Philharmonia, which was recently released on the Albany Records label. Other recent projects include collaborations with composers Inez McComas, Adam Har-zvi, and David Miller. Her debut solo album Dark Horse features works by Samuel Adler, Tony Plog, Reena Esmail, Shawn Davern, and the album's pianist, Thomas Weaver. A native of Park Ridge, Illinois, Brittany earned her Doctor of Musical Arts degree from Boston University, where she received the Brass Department Award. She also holds a Master of Music degree from Yale School of Music. With a deep commitment to education, she has previously served as faculty at the College of Musical Arts at Bowling Green State University and the Boston University Tanglewood Institute. She has also been a featured teacher and performer at summer festivals, including the Sewanee Music Festival and the DC Trombone Workshop. Recent residencies include those at the University of Central Arkansas, James Madison University (Tromblow'in), University of Iowa, Oklahoma State University, Stetson University, the University of Florida, and as the guest artist at the 2023 Frühling Posaunen hosted at Ithaca College. She has presented masterclasses at universities across the country and internationally. Brittany Lasch is an Edwards Trombone Performing Artist. She also proudly uses and endorses ChopSaver Lip Care. Outside of music, Brittany has recently completed her eleventh full marathon and loves spending time with her cats, Clove and Poppyseed.

There was a time when the typical family car was a four-door sedan, not unlike the 2025 Hyundai Sonata. But then the SUV craze hit, and families defected to crossovers like the 2025 Mazda CX-90. So this week, we litigate this issue with road tests of the hybrid version of the Sonata and the plug-in hybrid version of the CX-90. Host Jack Nerad road-tested the 2025 Mazda CX-90 PHEV Premium Plus, a three-row SUV that blends a 323-horsepower plug-in hybrid powertrain with upscale features. Its e-Skyactiv PHEV system offers an estimated 26-mile all-electric range and a total range of 490 miles. Beyond its power and fuel economy, it features an eight-speed automatic transmission, several drive modes, and i-ACTIV all-wheel drive. Inside, the seven-passenger cabin features Nappa leather, ventilated front seats, heated second-row captain's chairs, a 12.3-inch infotainment display, and a 12-speaker Bose system. A full suite of advanced safety features ensures peace of mind, while its 3,500-pound towing capacity adds versatility. Across the country, co-host Chris Teague spent a week behind the wheel of the 2025 Hyundai Sonata Limited Hybrid, a midsize sedan that combines style, comfort, and strong fuel economy. Powered by a 2.0-liter engine and electric motor that delivers torque through a six-speed automatic transmission, the handsome four-door delivers an impressive 47 mpg combined. Key features include a panoramic sunroof, 17-inch alloy wheels, and leather-trimmed heated and ventilated front seats. From the tech perspective, the Sonata offers a 12.3-inch touchscreen with navigation, wireless Apple CarPlay and Android Auto, Bose premium audio, and a surround-view monitor. Advanced safety technologies such as forward collision-avoidance assist, blind-spot collision warning, and highway drive assist round out the package. So, which of these is the better family car, circa 2015? We'll share our thoughts. Turning to the news, we examine how tariffs are impacting U.S. car prices. While average prices rose only 0.8% year-over-year in April, tariffs have led to somewhat sharper increases on some imported vehicles. As pre-tariff inventory thins, supply is tightening, and affordable new cars are becoming harder to find, especially as models like the Nissan Versa exit the sub-$20,000 segment. We also take a look at AAA's newest survey, which shows consumer interest in EVs is declining. Only 16% of respondents said they would likely choose an EV for their next vehicle, while 63% are unlikely to do so. Top concerns include battery repair costs and high purchase prices, despite improving durability and falling prices in some EV segments. We'll give you our thoughts as well. In response to slowing demand, Lucid Motors is slashing prices on its 2025 Air lineup, offering up to $31,500 in savings on the Air Grand Touring. Other trims see discounts as well, as Lucid seeks to better compete with Tesla and other luxury EV makers. Finally, we highlight Volkswagen of America's celebration of International Volkswagen Bus Day. VW is restoring the 1977 T2 “magic bus” that survived Southern California's Palisades fire, honoring the VW bus legacy, from the classic T1 to today's all-electric ID. Buzz. This week's listener question comes from Ronald in Stockton, California, who asks: “I've had trouble with my windshield wipers over the years, and I'm wondering if I just don't replace them often enough. Do you have any thoughts on windshield wipers? Should I clean my windshield when I install them?” Chris and Jack will have the answers from the experts. Jack Nerad's newest book Jack is now offering his newest crime novel, Only One Thing Stays the Same, at a pre-publication price of just $4.99. Click here to buy from Amazon at this special limited-time price. Matt DeLorenzo's Book Pick up a copy of co-host Matt DeLorenzo's terrific new book How to Buy an Affordable Electric Car: A Tightwad's Guide to EV Ownership.

The loop reveals itself to be more complicated than previously thought. The crew is launched forward through Sonata to show a completely different, new side to the off-putting symphony. Discover what exists in this neck of the timeline with us in this episode of The Forever DMs! Hosted on Acast. See acast.com/privacy for more information.

SHOSTAKOVICH: Sonata para piano nº 2, Op. 61 (25.22). E, Gilels (p.). Suite sobre temas finlandeses (11.12). Orq. Fil. de Helsinki. Dir.: V. Ashkenazy. Preludio y fuga nº 6 en Si menor, Op. 87 (5.01). D. Shostakovich (p.).Escuchar audio

Five commercial Liszt Sonata recordings that deserve wider recognition:Van Cliburn - https://www.youtube.com/watch?v=CmyFMhtJngcJitka Čechová - https://www.supraphon.com/album/96-brahms-liszt-live-at-the-rudolfinumBoris Berezovsky - https://www.prestomusic.com/classical/products/7984370--boris-berezovsky-plays-liszt?srsltid=AfmBOoqEJKHu96EbKtmOz-nQ49y2jA-JVNeJKTTDZ6BHHAMJzTx0dVApAlexei Grynyuk - https://www.youtube.com/watch?v=SVyMCDz2JJcGeorge-Emmanuel Lazaridis - https://www.youtube.com/watch?v=5g5HBjoEFAI

A very early tale of cursed media - a story from 1944 concerning a vinyl record which has decidedly sinister effects on the listener ...

We would love to hear from you, wherever you are!https://www.perfectpitchpod.com/contact/@NickHelyHutchThank you for listening - please do get in touch with any comments!

SHOSTAKOVICH: Sonata para violín y piano, Op. 134 (31.21). D. Oistrakh (vl.), S. Richter (p.). 5 Canciones sobre poemas de Dolmatovsky, Op. 98 (12.21). F. Kuznetsov (baj.), Y. Serov (p.).Escuchar audio

Have you ever heard Contemplazione, a piece for orchestra by Catalani, the composer of La Wally? Have you ever heard “Who's Afraid of the Big Bad Wolf?”—but arranged for piano? These are two of the offerings in this eclectic, stimulating program. Catalani, “Contemplazione” Catalani, “Ebben? Ne andró lontana,” from “La Wally” Stravinsky, “Le Baiser de la fée” Shchedrin, “Changing of the Guard” from “Carmen Suite” Fauré, Pavane Churchill-Walford, “Who's Afraid of the Big Bad Wolf?” Tveitt, “Sonata etere” Sibelius, “Was It a Dream?” Weill, “My Ship”

Ludwig is unamused. The crew becomes desperate. Desperation becomes unnecessary.The Opera has only begun. Hosted on Acast. See acast.com/privacy for more information.

Title: The Enigmatic Scarlatti Track: Scarlatti's: Sonata in G Major, Kk. 14 Artist: Hank Knox (Harpsichord) Publisher: ℗ 2021 Leaf Music

As independently owned and operated small businesses, fast-food restaurant franchisees have unique business needs. They have mobile and often part-time workforces, complex inventory management and the constant challenge of managing both a small business and being the face of a major brand. On the latest episode of the ABA Banking Journal Podcast — sponsored by Bix2x — Wendell Bontrager talks about how Sonata Bank is working with this unique market segment. For example, “we can come in at fractional costs to provide them things like telehealth, mobile phone insurance, pet insurance, in a way that is free to the employee but is done and sold through the franchisee,” says Bontrager. He outlines Sonata's business of lending to “quick-service” restaurants, as they're often called in the trade, paired with employee benefits, treasury management and a software-as-a-service platform for QSRs. Bontrager also talks about the health of the Nashville, Tennessee, market where Sonata's community bank franchise is headquartered and how the organization has been able to capture talent with hybrid and remote workplace offerings.

AI is everywhere. It hasn't really affected music yet, or has it? Help support The Next Track by making regular donations via Patreon (https://www.patreon.com/thenexttrack). We're ad-free and self-sustaining so your support is what keeps us going. Thanks! ‌Show notes: Perplexity (https://www.perplexity.ai) Microsoft made an ad with generative AI and nobody noticed (https://www.theverge.com/news/656104/microsoft-surface-ad-generative-ai-copilot-intel) How Daydreaming Can Enhance Creativity for Fiction Writers (https://www.literatureandlatte.com/blog/how-daydreaming-can-enhance-creativity-for-fiction-writers) The Next Track: Episode #305: Timo Andres on Steve Reich's Collected Works (https://www.thenexttrack.com/310) Sonatas and Interludes - Wikipedia (https://en.wikipedia.org/wiki/Sonatas_and_Interludes) Our next tracks: John Cage, Sonatas and Interludes, James Tenney (https://amzn.to/4jK2uPm) Corey Harris: Greens From the Garden (https://amzn.to/44XhYeA) If you like the show, please subscribe in iTunes (https://itunes.apple.com/podcast/the-next-track/id1116242606) or your favorite podcast app, and please rate the podcast.

Chaos descends upon Gaia Defaced in the form of mechanized militant mobilization! As Wagner Protocol is engaged by Sergeant Tchaikovsky, the crew scramble to keep their new allies alive, and bring him down. How will the crew work through this battle? You most certainly will not guess correctly. Get bonus content on Patreon Hosted on Acast. See acast.com/privacy for more information.

Police discover an unconscious man in Central Park who's been the victim of a theft - of his kidney! Det Sgt Max Greavey and Det Mike Logan learn the daughter of wealthy Phillip Woodleigh suddenly withdrew from the organ transplant list. They discover surgeon James Reberty rented portable surgical equipment and find bloody bandages at his nurse's apartment. ADA Paul Robinette says Reberty didn't sew off the renal artery, suggesting he wanted the victim/donor to die. EADA Ben Stone believes Woodleigh paid the surgeon $2 million to get a kidney for his daughter…by any means necessary.  We're talking about Law & Order season 1 episode 21 "Sonata for Solo Organ."Our guest from our May 22, 2019 episode is Dan Taberski, from "Missing Richard Simmons," "Running from COPS," and “Hysterical.” The episode was inspired by the 1989 organ scandal involving Amhet Koc. NEW EPISODES OF "THESE ARE THEIR STORIES" RETURN JULY 9!For exclusive content from Kevin and Rebecca, sign up on Patreon.

This year marks the one hundred and fiftieth anniversary of Maurice Ravel's birth. So we have been hearing a lot of him. Jay plays two pieces by him—two of his best, and most typical. There are also Spanish songs, by Obradors and Rodrigo. Some Schumann, some Vaughan Williams, and so on. Plus several stories—personal ones. An enriching, smile-making program. Obradors, “Del cabello más sutil” Rodrigo, “De ronda” Bernstein, Sonata for Clarinet and Piano Beethoven, “Leonore” Overture No. 3 Vaughan Williams, “Linden Lea” Ravel, “Pavane for a Dead Princess” Schumann, Sonata in D minor for Piano and Violin Handel, “Son nata a lagrimar,” from “Giulio Cesare” Ravel, “The Fairy Garden” from the “Mother Goose” Suite

What does it really take to modernize an enterprise in a world of constant disruption, increasing AI capabilities, and evolving customer expectations? In this episode of Tech Talks Daily, I sit down with Rajsekhar Datta Roy, Chief Technology Officer at Sonata Software, to explore how modernization engineering and responsible AI adoption are reshaping business transformation strategies. Raj brings decades of experience to the conversation, guiding organizations through the complexities of aligning technology with business value. We begin by unpacking what modernization truly means in today's environment. Rather than a single event, Raj explains how modernization is a continuous process that blends operational efficiency with agile frameworks and a readiness to adapt to future technologies like AI.  My guest shares Sonata Software's structured approach to modernization, designed to generate efficiency from existing systems and redirect those savings into smarter, faster innovation cycles. We also explore the growing role of generative AI in digital transformation. Raj outlines the importance of moving beyond surface-level applications, advocating for a deeper integration of AI into reimagined business processes. He discusses Sonata's responsible-first approach to AI, including its governance framework and platform-level deployment strategy that ensures secure and ethical implementation.  The result is not only a future-ready enterprise, but one that can deliver measurable value through better customer experiences, faster decision-making, and scalable AI adoption. As we zoom out, Raj highlights key ecosystem shifts, such as the growing importance of cross-industry collaboration and transforming customer expectations in the age of intelligent agents. He also offers advice on how to modernize without disrupting core systems, emphasizing the value of continuous learning, hands-on experimentation, and practical frameworks that reduce time to impact. If your organization is navigating digital transformation or exploring responsible AI deployment, this conversation offers both a strategic lens and real-world examples to help you move forward with clarity. How are you preparing your technology stack and business processes for what comes next? Let's continue the conversation.

As the orchestra continues it's performance, the three key players find their places. They settle in besides a discovered section of the show, and learn more about the society around them. Will they be able to find their footing before the performance gains pace? Or shall they slip before they can take their place? Find out in this continuation of the Saprophite Sonata on the Forever DMs! Get bonus content on Patreon Hosted on Acast. See acast.com/privacy for more information.

Thu, 17 Apr 2025 23:00:00 +0000 https://seesee.podigee.io/s3e18-andrei-ionita 8b306c6e95ffcb5e607b501afe394bac In this episode, we have an in-depth conversation with Andrei Ioniță, the prodigious Romanian cellist and winner of the 2015 International Tchaikovsky Competition. We explore the emotional profundities and rich spectrum of colors that the cello can evoke, and how it reflects the subtleties of human emotion. Andrei shares his thoughts on playing Bach, discussing the personal connection he has with his instrument and his journey as a musician. He also reflects on the nuances of gut strings, the importance of good posture for a cellist, the physical sensation of the cello resting against his body, and how this intimate embrace influences emotional expression and depth of sound, particularly in the intense, low register passages. In this episode dedicated to music, Andrei also discusses his Romanian heritage and how the voice of Romania speaks through his bow, offering a personal insight into his cultural identity. In this episode, he takes us inside his experience during the 15th Tchaikovsky Competition and talks about his most difficult decisions as a musician. Most powerfully, Andrei opens up about how he conveys his whole soul through his music, sharing the courage it takes to be vulnerable and break through at the highest emotional peaks, only to let go and invite the listener into a shared human experience through his playing. This episode is a real treat for the ears and the heart! Andrei Ioniță's carrier it's a journey of emotional reflection and artistic courage – You'll understand what it is meant to “play from the gut”. Website: https://www.andreiionitacellist.com https://www.haefligerproduction.com/andrei-ionita https://www.symphonikerhamburg.de/laeiszhalle-orchester-symphoniker-hamburg/andrei-ionita-135 Instagram: ionita_andrei94 Facebook: Andrei Ioniță - Cellist This episode's Playlist and Playlist's credits: · Papandopulo, Boris. Rhapsodia Concertante: I. Introduzione Tempo Libero. Performed by Oliver Triendl and Andrei Ioniță. On Boris Papandopulo: Works for Piano & Strings, CPO-555106-2, 2021.CD · Tchaikovsky, Pyotr Ilyich. Variations on a Rococo Theme, Op. 33 (var. VII e Coda : Allegro vivo). Performed by Cellist Andrei Ioniță and the Münchener Philharmoniker conducted by Valery Gergiev recorded at the Philharmonie im Gasteig (Munich, Germany), on May 12, 2017 20:00 © A Coproduction by Munich Philharmonic Orchestra & Telmondis // In Association with medici.tv & Takt1 https://www.youtube.com/watch?v=-6dyn2LRxVo · Brett, Dean. 11 Oblique Strategies No. 1. Listen to the Quiet Voice. Performed by Andrei Ioniță. On Oblique Strategies. Orchid Classics ORC100096, 2019. CD. · Brett, Dean. 11 Oblique Strategies No. 5. What are the Sections Sections of? Performed by Andrei Ioniță. On Oblique Strategies. Orchid Classics ORC100096, 2019. CD. · Brahms, Johannes. Cello Suite No. 1 G Major, BWV 1007: I. Prelude. Performed byAndrei Ioniță. On Oblique Strategies. Orchid Classics ORC100096, 2019. CD. · Brahms, Johannes. Cello Suite No. 1 in G Major BWV 1007: III. Courante. Performed by Andrei Ioniță. On Oblique Strategies. Orchid Classics ORC100096, 2019. CD. · Brahms, Johannes. Clarinet Trio in A Minor, Op. 114: I. Allegro. Performed by Pablo Barragán, Andrei Ioniță, and Juan Pérez Floristán. On Brahms: Complete Clarinet Sonatas & Trio. IBS Classical, 2018. CD. · Papandopulo, Boris. Concertino in modo antico, OP.56 II Aria. Performed by Oliver Triendl, Amaury Coeytaux, Vanessa Szgeti, and Andrei Ioniță. On Boris Papandopulo:Works for Piano & Strings, CPO-555106-2, 2021.CD · Dmitri, Shostakovich. Sonata for Cello and Piano in D Minor, Op.40. The XV International Tchaikovsky Competition. Performed by Andrei Ioniţă: Cellist and Seong-Jin Cho: Pianist. Concert recorded at the Salle des Combins (Verbier, Switzerland), on July 25, 2018. © Idéale Audience with the participation of medici.tv https://www.youtube.com/watch?v=iHPd1dN89bM · Dmitri, Shostakovich. Cello Concerto No. 1 in E-flat major, Op. 107 4. Allegro con moto. Performed by Andrei Ionuț Ioniță with the Mariinsky Theatre Symphony Orchestra conducted by Valery Gergiev. The XV International Tchaikovsky Competition's Winners' Concert. Recorded at the Great Hall of the Moscow Conservatory, on July 2, 2015. © MUSEEC/medici.tv https://www.youtube.com/watch?v=zzaCNTlJciI · Dmitri Shostakovich. Cello Concerto No. 1 in E-flat major, Op. 107 with the Draft. Performed by Andrei Ionuț Ioniță Orchestra of the Shostakovich State Academic Saint Petersburg Philharmonic conducted by Nikolai Alexeev. Cello: Final Round - Candidate #2 - First Prize - Recorded at the Grand Hall of the Saint Petersburg Philharmonia, on June 28, 2015, 7:45 p.m. https://www.youtube.com/watch?v=QfkQt0gSiJI · Henryson, Svante. Black Run. Performed by Andrei Ioniță. On Oblique Strategies. Orchid Classics ORC100096, 2019. CD. · Enescu, George: Piano Quartet No. 1 in D Major, Op. 16: II Andante mesto. Performed by Catalin Serban, Andrei Ioniță, Karolina Errera, Suyeon Kang. On Mélodies Infinies: Fauré & Enescu Piano Quartets. Naxos 8.551477, 2024. CD · Papandopulo, Boris. Rapsodia Concertante: I. Introduziene. Tempo libero. Performed by Oliver Triendl, Amaury Coeytaux, Vanessa Szgeti, and Andrei Ioniță. On Boris Papandopulo: Works for Piano & Strings, CPO-555106-2, 2021.CD · Rachmaninoff, Sergei: Sonata -Moll OP 19. Lento- Allegro moderato. 2. Allegro scherzando. 3 Andante. 4 Allegro mosso. Performed by Andrei Ioniță and Andrei Ioniță (Violoncello), Catalin Serban (Piano). Kammermusik am Max-Planck-Institut für Bildungsforschung in Zusammenarbeit mit Konzertleben e.V. January 17th, 2024. https://www.youtube.com/watch?v=QqpFqwfoBDg · Saint-Saëns, Camille. Concerto No.1 in A minor for Cello and Orchestra Op. 33. Performed by Solist Andrei Ioniță and the Filarmonica George Enescu conducted by Stefan Ausbury Opening Concert October 7th, 2020, at the Romanian Athenaeum lived-streamed on the Institutions Website and YouTube Channel. https://www.youtube.com/watch?v=ktTHMbFcyp4 · Papandopulo, Boris. Rapsodia Concertante: I. Introduziene. Tempo libero. Performed by Oliver Triendl, Amaury Coeytaux, Vanessa Szgeti, and Andrei Ioniță. On Boris Papandopulo: Works for Piano & Strings, CPO-555106-2, 2021.CD · Rachmaninoff, Sergei: Sonata -Moll OP 19. Lento- Allegro moderato. 2. Allegro scherzando. 3 Andante. 4 Allegro mosso. Performed by Andrei Ioniță and Andrei Ioniță (Violoncello), Catalin Serban (Piano). Kammermusik am Max-Planck-Institut für Bildungsforschung in Zusammenarbeit mit Konzertleben e.V. January 17th, 2024. https://www.youtube.com/watch?v=QqpFqwfoBDg · Fauré, Gabriel: Piano Quartet No. 1 in C Minor, Op. 15: III Adagio. Performed by Catalin Serban, Andrei Ioniță, Karolina Errera, Suyeon Kang. On Mélodies Infinies: Fauré & Enescu Piano Quartets. Naxos 8.551477, 2024. CD https://www.youtube.com/watch?v=ktTHMbFcyp4 · Saint-Saëns, Camille. Concerto No.1 in A minor for Cello and Orchestra Op. 33. Performed by Solist Andrei Ioniță and the Filarmonica George Enescu conducted by Stefan Ausbury Opening Concert October 7th, 2020, at the Romanian Athenaeum lived-streamed on the Institutions Website and YouTube Channel. https://www.youtube.com/watch?v=ktTHMbFcyp4 · Brahms, Johannes. Clarinet Trio in A Minor, Op. 114: I. Allegro. Performed by Pablo Barragán, Andrei Ioniță, and Juan Pérez Floristán. On Brahms: Complete Clarinet Sonatas & Trio. IBS Classical, 2018. CD. · Papandopulo, Boris. Rhapsodia Concertante: III. Danza. Allegro. Performed by Oliver Triendl and Andrei Ioniță. On Boris Papandopulo: Works for Piano & Strings, CPO-555106-2, 2021.CD Albums: Available in all Platforms https://open.spotify.com/intl-de/album/3Cqhwf6m3Gl8i0HfDTzln1 https://www.naxos.com/CatalogueDetail/?id=C5463 https://open.spotify.com/intl-de/artist/4ITCrIEQbzQVUO8CPHhdLP 3 18 full no Cellist,World famous orchestras,world famous conductors,Tchaikovsky Competition,Bach,Shostakovich,Enescu,Fauré,Gut strings,Posture Dr. Cecilia Ponce Rivera

For Earth Day, we release the glorious Earth Harmony Sonata. It features Earth photography by astronauts Suni Williams and Butch Wilmore, who just returned from their extended stay on the ISS. Wilmore captures a mesmerizing flight path from equatorial Africa, over the Sahara and Middle East and on up to Armenia. Williams took over 10,000 photographs, with a sensitive and artistic eye. Here are 60 favorites, covering the world. The music is Bach's Trio Sonata #5 for organ, played by maestro Brian Hoffman. Celebrate Earth Day with this feast for eyes and ears. We live on a beautiful planet – please love and care for it. Series: "Arts Channel " [Arts and Music] [Show ID: 40664]

This is Episode No. 100 of “Music for a While.” To mark the occasion, Jay presents music associated with that number: 100. So, we can consider this a centennial celebration. Bach, “Darum wir billig loben dich,” from the Cantata BVW 130 Dvořák, Scherzo from Sonatina for Violin and Piano, Op. 100 Bach, “Er ist mein Licht, mein Leben,” from the Cantata BVW 100 Haydn, Presto, from Symphony No. 100 in G major, “Military” Beethoven, “Merkenstein” Prokofiev, Allegro marcato, from Symphony No. 5 Mozart, Serenade No. 1 in D Brahms, Sonata for Violin and Piano No. 2 in A major Schumann, “The Bride of Messina,” Overture in C minor Shostakovich, “Little Stars” from “Spanish Songs” arr. Vaughan Williams, “Old Hundredth Psalm”

We would love to hear from you, wherever you are!https://www.perfectpitchpod.com/contact/@NickHelyHutchThank you for listening - please do get in touch with any comments!

主播｜李志明 嘉宾｜马家辉本期节目的嘉宾是知名作家，文化评论者马家辉先生，这是一次关于自我和家庭的对谈。《你不必着急成为一个大人》是马家辉与太太张家瑜的亲情散文之书，集结了三十年间二人写给女儿的文章。即便写作对象是女儿，创作的实质却是“为自己”，核心仍是探索自我与生命的关系。而字里行间流露出的温柔，则是他借用康德的“无上律令”对自己提出的要求和期待，但更是一种自我训诫。提到女儿时，马家辉的语调总会柔软几分，他回忆女儿幼时戒奶嘴的独立瞬间，也反思自己在冲突时的情绪失控，同时也因家庭的“语言治疗”习惯而庆幸着。谈及当下的原生家庭困境，马家辉拒绝简化善恶，两代人的痛苦，往往因社会支撑缺失而被放大，原谅或者不原谅，都是个体的命运选择。所谓亲子关系，终究是一场向内探索的旅程，父母与子女互为镜鉴，而后在漫长的岁月里与不完美的自己温柔和解。马家辉先生今天带着新书来做客，也有一段话要送给各位：你手里的这本书并不只是一父一母为孩子而写的文章。它更是自我叩问之书。之于我，“高中生”只是个象征符号，“过期的”则是个不太重要的年龄数字。高中生，其实也可以改头成小学生、大学生，或者社会人，而无论贴上什么标签，关键只在于是否仍对世界和生命抱持着探索的热情和探奇的欲望。｜song list｜片头曲：Sonata for Piano and Violin in E minor K. 304: 2. Tempo di minuetto片尾曲：12 Variations on "Ah, vous dirai-je, Maman", K.265 (300c)｜timeline｜01:53 《你不必着急成为一个大人》是自我叩问之书05:24 我希望女儿不要读我的文章，同样我也不敢读她的文章11:22 温柔是基于康德的“无上律令”，对自己提出的要求和期待18:07 接受自己是个“不完美”父亲，遗憾常有，有些事情就let go吧26:02 面对原生家庭问题，和解或是斗争都是个体的命运选择30:10 成长并非一个瞬间，而是点点滴滴的积累39:55 孩子的自由与管教如何平衡？44:37 乐观也是一种人生策略48:26 你是谁的父亲不重要，你是谁才最重要57:37 原生家庭的困境往往因社会支撑缺失而被放大1:02:10 对任何人都可以有期待，但永远无法控制1:06:32 成为父亲和丈夫以来最大的变化，是学会站在别人的角度看自己1:11:19 “家辉”背后的家族记忆与责任传承｜本期嘉宾｜马家辉，曾任职于广告公司、报社、杂志社，后赴美留学，先后取得美国芝加哥大学社会科学硕士、美国威斯康星大学社会学博士学位。曾担任《明报》副总编辑。出版散文集《大叔》《死在这里也不错》等。长篇小说《龙头凤尾》和《鸳鸯六七四》获多个文学奖项，有韩文及法文译本。现正撰写“香港三部曲”第三部《双天至尊》。｜相关链接｜本书是著名作家马家辉、张家瑜合著的散文集。自女儿出生之日起的成长轨迹与亲子互动片段，父母在女儿不断成长、转变过程中的喜悦、烦恼、惶惑和反省，在或轻快或深情的笔端一一呈现。父母心情熔铸一体，将温暖朴素的爱藏在日常岁月中，立体地展现了在孩子成长中，父母如何成为现在的父母。在整个过程中，他们一同经历了挫败并获得成长满足、失望，以及笑声和泪水促成了他们生命的惊喜与灵魂的更新。每个人都有自己的花期按照自己的节奏开花长大就好。｜节目中提到的书籍和电影｜《你不必着急成为一个大人物》作者：马家辉《大叔：我们终于可以聊聊走过的路》作者：马家辉《我是开豆腐店的，我只做豆腐》作者：小津安二郎《父亲的道歉信》作者：向田邦子《宛如阿修罗》导演：是枝裕和《年轻气盛》导演：索伦蒂诺《封神第一部：朝歌风云》导演：乌尔善｜相关图片｜逛模型店秋叶原李小龙模型61岁正是拼的年纪环球影城马老师爱扭蛋和抓娃娃机【收听平台】小宇宙｜喜马拉雅｜苹果播客｜网易云音乐｜荔枝｜蜻蜓FM｜QQ音乐｜酷我音乐｜酷狗音乐｜懒人听书｜微博音频｜三联中读｜听听FM｜猫耳FM｜Spotify｜YouTube｜关注我们｜移步点击日谈公园品牌官网（链接：https://www.ritanbbpark.com），了解更多微信公众号：日谈公园微博：@日谈公园小红书：日谈公园即刻：日谈李小日B站：日谈公园｜商务合作｜欢迎发送邮件至 bbpark@ritanbbpark.com

We return once again with a brand new arc DM'd by Tom! Follow as they weave a brand new plot for us goons to traverse through and break in fun ways. Only this time, breaking things might lead to some major consequences. Listen in and be immersed in the Saprophite Sonata, and find out what has gone awry in this arc of The Forever DMs! Get bonus content on Patreon Hosted on Acast. See acast.com/privacy for more information.

ReferencesFront Aging Neurosci. 2014 Sep 25;6:252.Neural Regen Res. 2020 Jun 19;15(12):2173–2185FASEB 2020. Volume34, Issue5: 6570-6581 Scarlotti, D. 1746-58. Sonatas. https://music.youtube.com/watch?v=X-JaVGYG2i8&si=0jfOkPD2CZs68UnoVivaldi, A.1713. Gloria RV 588.https://music.youtube.com/watch?v=xpZUSAIQyLo&si=gAg5KKWJYxk_u0vnJoel, B. 1976. "Angry Young Man"https://music.youtube.com/watch?v=M2iNLt_hUZg&si=wYhGCSUztMk1RakJ

Dave Showing Off the Sonata 03/20/25

In this episode of The ABMP Podcast, Doug Nelson explores the fascinating connections between the artistry and structure of music—think orchestra, composition, and rhythm—and how it parallels the flow and intention behind a well-crafted massage therapy session. Host: Douglas Nelson is board certified in massage therapy and therapeutic bodywork, beginning his career in massage therapy in 1977. Seeing over 1,200 client visits annually for decades, he is also the owner of BodyWork Associates, a massage therapy clinic in Champaign, Illinois. with 21 therapists that was established in 1982. He is the founder of NMT MidWest, Inc., providing training in Precision Neuromuscular Therapy across the USA. He has personally taught more than 13,000 hours of continuing education and is the author of three books. Doug is a past president of the Massage Therapy Foundation. Sponsors:   Anatomy Trains: www.anatomytrains.com     American Massage Conference: https://www.massagetherapymedia.com/conferences   Anatomy Trains is a global leader in online anatomy education and also provides in-classroom certification programs for structural integration in the US, Canada, Australia, Europe, Japan, and China, as well as fresh-tissue cadaver dissection labs and weekend courses. The work of Anatomy Trains originated with founder Tom Myers, who mapped the human body into 13 myofascial meridians in his original book, currently in its fourth edition and translated into 12 languages. The principles of Anatomy Trains are used by osteopaths, physical therapists, bodyworkers, massage therapists, personal trainers, yoga, Pilates, Gyrotonics, and other body-minded manual therapists and movement professionals. Anatomy Trains inspires these practitioners to work with holistic anatomy in treating system-wide patterns to provide improved client outcomes in terms of structure and function.                      Website: anatomytrains.com                        Email: info@anatomytrains.com             Facebook: facebook.com/AnatomyTrains                       Instagram: www.instagram.com/anatomytrainsofficial   YouTube: https://www.youtube.com/channel/UC2g6TOEFrX4b-CigknssKHA     American Massage Conference   Get ready to immerse yourself in the excitement as the American Massage Conference (AMC) arrives to Disney Springs near Orlando, Florida (May 16th-18th, 2025)! With a legacy of 17 successful years in Ontario, Canada, this premier event, proudly hosted by ONE Concept Conferences and expertly produced by Massage Therapy Media (MTM), boasts a lineup of presenters from across the nation and around the globe.   The American Massage Conference began in Atlanta in 2011 and has been hosted through the years in San Diego, Chicago, and Virginia Beach. The conference provides educational opportunities with engaging one-, two-, three- and four-hour class formats, networking opportunities, masterminds, MTM Talks, demonstrations, and an extensive exhibitor tradeshow.     Mark your calendars for an unforgettable experience filled with education, networking, and the celebration of massage therapy excellence! ABMP members receive a special discount to attend this in-person conference—log in to your ABMP account to access the discount code and register today.   Website: https://www.massagetherapymedia.com/conferences    

This week join David and Ian as they cover the latest Halo audio book -Venezian SonataEnjoy

Today's sponsor is Freed AI! Freed's AI medical scribe listens, transcribes, and writes notes for you. Over 15,000 healthcare professionals use Freed and you should too! Learn more here! On this episode of the Real Life Pharmacology Podcast, we will cover medications 186-190 on the Top 200 Drugs List. The medications included in the podcast episode are Sonata, Zebata, Zovirax, Coumadin, and Luvox. Sonata (ezopiclone) is a Z-drug used for insomnia. It has many similar effects to benzodiazepines and a similar mechanism of action. Zebeta (bisoprolol) is a beta-blocker used for the treatment of hypertension, atrial fibrillation, and heart failure amongst other indication. Zovirax (acyclovir) is an antiviral medication used to treat various viral infection. It needs to be dosed numerous times throughout the day which is a downside to use. Coumadin (warfarin) is an anticoagulant. It is most well known for its need to have INRs drawn to assess drug levels. Luvox (fluvoxamine) is an SSRI antidepressant. It is well known for its ability to cause drug interaction and is often not a first line agent because of this reason.