Podcasts about kcc

Dr. Deb Muth 00:00:09 Hi there, how are you? Bob Miller 00:00:10 Excellent! Pedaling as fast as humanly possible, but doing okay. Dr. Deb Muth 00:00:14 Good, good. Well, I’m looking forward to our conversation today. This should be amazing. Bob Miller 00:00:20 Yeah, it should be a lot of fun. Dr. Deb Muth 00:00:22 Yeah, anything that’s off-limits for you in, our conversation? Bob Miller 00:00:28 No. Dr. Deb Muth 00:00:29 Okay, anything you want me to make sure we cover for you? Bob Miller 00:00:33 Well, I mean, is it okay if we put a little plug-in for our software? Dr. Deb Muth 00:00:35 Absolutely. Bob Miller 00:00:36 Yeah. Dr. Deb Muth 00:00:37 Absolutely. Bob Miller 00:00:36 Yeah. Dr. Deb Muth 00:00:37 Absolutely. Bob Miller 00:00:38 Hey, can we… can we do a screen share? Yes, we can. Yeah, because I want to show you some maps, and… Dr. Deb Muth 00:00:43 Okay. Things like that, yeah, so… Perfect. So just let me know when you want to do screen share. Bob Miller 00:00:48 Okay. Dr. Deb Muth 00:00:49 And yeah, feel free to plug your software wherever you want to. Bob Miller 00:00:53 Okay, well, good. Let me pull up a, a slide for that, and give me one second, I just want to shut the door to my office to get the noise down. Dr. Deb Muth 00:01:01 No worries. Bob Miller 00:01:16 And, how should I refer to you? Dr. Debb? Dr. Muth, what do you like? Dr. Deb Muth 00:01:18 Dr. Deb is great, or Deb, either way, I’m pretty informal, so… Bob Miller 00:01:22 Yeah, and… Bob is fine for me. Okay. Yeah. Yeah, there you go. Why people feel like they need this, son. Special name, it’s like, seriously. Dr. Deb Muth 00:01:33 Right? I agree. Bob Miller 00:01:35 When I work with my clients, it’s like, Dr. Millison, just, just bop, just, just bop. Dr. Deb Muth 00:01:41 Yep, that’s how I am, too. Just call me Deb, it’s good. Dr. Deb Muth 00:01:44 They feel a little awkward with that, you know? They’re not used to that, but… Bob Miller 00:01:48 Alright. And you’re a naturopath, medical doctor. Dr. Deb Muth 00:01:52 A nastropathic doctor and a nurse practitioner. Oh, nice. Yeah, so I got the best of both worlds, right? Bob Miller 00:01:58 Yeah, damn. Okay. Alright, so here we go… There we go. Alright, so I got that ready, and then I will do a, I will do a screen share. I think you’re gonna really, appreciate what we’ve come up with. We’ve come up with the concept of, Cellular CPR. Dr. Deb Muth 00:02:23 Oh, nice! Bob Miller 00:02:24 And that is, construct the cell membrane, Protect the cell membrane. And restore it if it’s damaged. Dr. Deb Muth 00:02:32 Love that. Bob Miller 00:02:34 I love that. Yeah, so that’s what we’re focusing on, and then how, You know, we want to get to the point that, you know, most people think of genetics, they think of, like, 23andMe or Ancestry. Dr. Deb Muth 00:02:44 Yeah. Bob Miller 00:02:45 And then you have the professional geneticists who are looking at, you know, odd things that could create a disease. We’re looking at functional genomics. Dr. Deb Muth 00:02:54 Which is so much better. Bob Miller 00:02:56 Yeah. Are you familiar with what we do here, or… Dr. Deb Muth 00:02:58 A little bit, a little bit. So, it’ll be new to me, too, so I’m excited. Bob Miller 00:03:03 And how much time do we have? Dr. Deb Muth 00:03:04 We have an hour, give or take a little bit on either side. Do you have a hard stop anywhere? Bob Miller 00:03:10 No, no, I put a, I moved my clients around, and I don’t have anybody till, 3.30, so we’re good. Okay. Dr. Deb Muth 00:03:16 Perfect. Alright. Bob Miller 00:03:18 It’s like we’re getting started early as well, so… Dr. Deb Muth 00:03:19 Yeah, we’re getting started a little bit early, so that’s good. Bob Miller 00:03:22 Yeah, I just got my office cleaned up, so… Dr. Deb Muth 00:03:23 Okay, good. All right, are you all set to get started? Bob Miller 00:03:28 I’m good to go, my friend. Dr. Deb Muth 00:03:29 I’m gonna just record a little intro and a little bit of a, hook for people, and then we’ll get started. I’ll ask you to kind of tell us a little bit about yourself, and then we’ll just take this conversation wherever it’s supposed to go. Bob Miller 00:03:39 Okay, you got it. Dr. Deb Muth 00:03:40 Alright, sounds good. So what if the reason you’re not healing isn’t your diet, your supplements, or your labs, but it’s actually your genes? Dr. Bob Miller is uncovering how genetic variants, when combined with modern toxins, explain why some of us stay sick no matter what we try. Today, we’re talking genetic pathways, detox blocks, and the new science every wellness warrior needs to know. Welcome back to Let’s Talk Wellness Now, the show where we uncover the root causes of chronic illness, exploring cutting-edge regenerative medicine, and empower you to heal from the inside out. I’m Dr. Deb, your medical detective, and today, our guest, Dr. Bob Miller, is a true pioneer in functional genomics. He’s a board-certified traditional naturopath and the founder of Neutrogenetic Research Institute. And he’s the leading groundbreaking research on how genetic variants influence chronic illness, inflammation, and detoxification. His work has been recognized on international stages, uncovering links between genetic expression and conditions like Lyme disease, mast cell activation, or MCAS, and mitochondrial dysfunction. I’m so excited to talk to Dr. Bob today. He is gonna reveal some things that even I don’t know about, so I’m excited to learn alongside of you guys. So… Dr. Bob, let’s get started. Tell us a little bit about yourself, and kind of how you got on this journey. Bob Miller 00:05:04 Well, that’s, that’s interesting. I was sort of like a mid-career coming to the natural health field, because in my early 30s, I found myself with a severe case of ulcerative colitis. Bob Miller 00:05:15 And I was in the hospital for 21 days. probably within hours of death, pleading to death. And they told me I’ve got one option, and that is cut out the colon and wear a bag. Didn’t sound like a lot of fun. Dr. Deb Muth 00:05:27 Not an option I would want. Bob Miller 00:05:29 So, you know, the medical folks wasn’t real happy with me, but I said, yeah, I’d like to explore some alternative things.Never thinking that I’d get into this field, and then I just, you know, worked with some herbalists and things that I found absolutely fascinating. So, that’s how I got into this around 30 years ago. And, haven’t looked back since, and just having a… having a blast as we now move into how our genetics impacts things. So, that’s what we’re gonna… that’s what we’re gonna talk about today. Dr. Deb Muth 00:05:58 I’m excited to talk about this genetic thing. When you started over 30 years ago, what kind of patience and problems first inspired you to dig deeper into that root cause healing and kind of get into the genetic piece of it? Bob Miller 00:06:10 Sure. Well, you know, as a… now, I’m in a part of the country called Lancaster County, Pennsylvania, where there’s a lot of Amish and Mennonite, and they gravitate towards these things.So, this is their first thing to do, and that doesn’t work, then they’ll go other routes. So, you know, back then, we just saw typical, you know, a little tired, constipation. You know, a little bit of fatigue, arthritis, those kind of things. But things have changed dramatically over the years, as people are now getting more chronically sick. You know, it’s worse than it’s ever been. And what we’re finding is the, the culprits Primarily is mold exposure and Lyme disease. When people get those two together, they’re just… it’s an inflammatory cascade that nobody can seem to unravel. So that’s where we spend a lot of our time. And we’re also spending a lot of time looking at mental health, like ADD, ADHD. And, we give… this year I’ll be speaking at three autism conferences. And we can dig into that a little bit as to why we think we’re seeing such a dramatic increase. And aside from autism, that used to be 1 out of 1,000, now it’s 1 out of 33, or 23. You know, we’re also seeing dramatic increases in ADD, ADHD. People are stressed out. And today, I think we’ll have the time to actually go through and show how environmental factors combine with genetics to cause that to happen. So we’ll… we should have a fun visit here today. And today, I think we’ll have the time to actually go through and show how environmental factors combine with genetics to cause that to happen. So we’ll… we should have a fun visit here today. Dr. Deb Muth 00:07:37 This should be a fun visit. We can cover lots of topics. I am so excited. So, you founded Nutri Genetic Research Institute in 2015. What did you hope to accomplish, and what kind of surprised you in your findings so far about that? Bob Miller 00:07:51 Well, you know, let’s back up at what, you know, genetics is used for. Everybody’s familiar with 23andMe and Ancestry that, you know, tells you where your ancestors came from. Then you have your professional geneticists. I mean, these are people with a degree in genetics. And they’ll look for, you know, very odd sort of things that are prone to relate to a disease. So there are disease-related genetics. Well, in functional, we don’t look at either of those. We look at For example, how you’re breaking down your fats and utilizing them. How you’re recycling your glutathione. How you might be handling your iron. And none of those are disease-causing on their own.And none of those are disease-causing on their own. But when they pile up on you, and then combine that with environmental factors, that’s when things start to go south on us. So, that’s what we’re doing, we’re looking at patterns. And our first foray into this was, we did studies on Lyme disease. And our first foray into this was, we did studies on Lyme disease. So, we looked at, like, I think 50 people with Lyme disease. We looked at their genome. So, we looked at, like, I think 50 people with Lyme disease. We looked at their genome. And we found patterns that were more evident in those with Lyme. Now, this doesn’t… these genetics don’t mean you get Lyme, it just means if you get Lyme, you react worse to it. And we found patterns that were more evident in those with Lyme. Now, this doesn’t… these genetics don’t mean you get Lyme, it just means if you get Lyme, you react worse to it. So, as you know, some people get Lyme, they go on a round of antibiotics, and they’re done. So, as you know, some people get Lyme, they go on a round of antibiotics, and they’re done. Others have a little more struggle, and then others are struggling terribly for years. So there’s an old adage of genetics loads the gun, environment pulls the trigger. Dr. Deb Muth 00:09:14 Yeah, that is so true, and I think when we’re talking about Lyme and mold and things like that, we forget sometimes that our genetics can predispose us to be more sensitive to those things, and if we have genetic pathways where we don’t clear things properly, it’s harder for us to get them out of the body. And then you add on that whole rain barrel effect that we’ve always used as a functional medicine term, right? If the barrel’s half full, you’re okay. If it’s full, and now it’s spilling over, it’s a bigger problem. Have you guys found, too, that some of these environmental things actually are changing the genetics of people, or how they’re processing their own genetics? Bob Miller 00:09:53 Well, let’s go back to, Genetics 101. But we’ll go back a little bit further. So, what an interesting mechanism, what a miracle the body is. Bob Miller 00:10:03 Fats, carbohydrates, proteins, drink water, breathe air, expose the sunlight, and somehow everything gets made. I mean, when you just step back and think about that, it’s like, It’s pretty darn amazing. Dr. Deb Muth 00:10:15 I always tell women, you know, the fact that we get pregnant and we have healthy pregnancies and births is a miracle, because if we had to try to control that, that wouldn’t work so well. Bob Miller 00:10:25 Right. Well, that’s another miracle. These microscopic sperm and egg, human being, 9 months later, it’s like. But even inside of us. We are making our hair, our skin, our nails, our blood vessels, our ATP, our energy, it’s all being created. Well, that gets created by enzymes. So, enzymes take one substance, combine it with something else, and make something new. Then another enzyme comes along and does the same thing. Your DNA is the instructions on how to make the enzymes. So, when we are conceived. If it’s a, if it’s a female, of course, it’s the XX, the two chromosomes. You know, we’ve… everybody’s seen those… the genetics that… Listed pair. So, if it’s a female, the father donated the X enzyme. And the mother has no choice but to give the eggs, so that’s female. If the father donates the Y, you have a male that’s in chromosome number 1. Then 2 through 23 is the rest of the instructions on how to make enzymes. So, what can happen? We can get what are called SNPs, single nucleotide polymorphisms. And SNPs just mean that the instructions to make the enzyme’s not quite as good. So, if one parent gives a SNP on the making of an enzyme, The enzyme’s fine. It works. But, general rule of thumb, It may only work at 70-80% of efficiency. Now, a good analogy is think of an 8-cylinder and a 6-cylinder car. If parents give you good information, that’s like having an 8-cylinder car. If one parent gives you that snip, it’s like having a 6-cylinder car. Now, is a 6-cylinder car a fine car? Sure. It’ll get you from point A to point B, but it’s just going to have the power of an 8-cylinder. Then if both parents give you a SNP on the same enzyme, it may be 30-40%, and that’s like having a 4-cylinder car. Sits in the driveway, looks the same, puts gas in it, everything. But if you’ve got a 4-cylinder car. Probably not a good idea to go cross-country pulling a trailer behind you up and down mountains. Dr. Deb Muth 00:12:29 This is true. Bob Miller 00:12:32 So… We can get an 8-cylinder, 6-cylinder, or 4-cylinder enzyme. Now, if it’s not under a lot of stress, if that 4-cylinder car is just taking you to the bank and the grocery store. It’s just as good as an 8-cylinder car. But if you gotta pull that trailer, and there’s a lot of stress on it, being mountains, it’s gonna struggle. Now, there’s one other little caveat to this, and that is some genetic mutations are gain-of-function. They actually work faster. Now, we have enzymes that do all kinds of things. We have enzymes that make and recycle our antioxidants, but we also have enzymes that make inflammation. No, that’s a good thing, because if we get a virus or bacteria, if you didn’t make inflammation to kill it, well, we’d all die of infection. So, you know, we tend to think of free radicals as bad, antioxidants as good. They both play an important role. But interestingly, some of the major enzymes that make inflammation, they can be overactive. They can be turbocharged. And when they’re stimulated by environmental toxins, they overreact. Bob Miller 00:13:40 And therein lies the problem. When they overreact, we have a problem. Bob Miller 00:13:46 So, if we have genes that overreact when stimulated. And then the enzymes that take care of inflammation are underactive. Then you’re gonna be more inflamed. You know, the majority of people that, you know, come for functional medicine Or naturopathic help, or… Inflammation that they can’t seem to get under control. Dr. Deb Muth 00:14:06 Right. Bob Miller 00:14:07 And we will be, you know, during this hour, we’re going to look at some of the pathways that make that happen. So, what we can do then, we can’t change our genetics. When you’re conceived, that’s the hand you’re dealt. When your life would be over, if someone would take some tissue and measure, it’d be exactly the same as conception. Does it change. Bob Miller 00:14:28 The enzyme’s ability to do its job may be compromised. Because remember I said there’s a, the enzyme takes a cofactor. So an enzyme takes substance A, cofactor, make substance B. Well, if that cofactor’s not there, the enzyme’s not going to work either. So, you could have an 8-cylinder car, and if there’s no gas in it, it’s not going anywhere. So… It’s the strength of the enzyme, it’s the cofactor to do the A to B conversion. And that’s what we’re going to get into. So, many people say, well, where did these SNPs come from? Nobody knows for sure. Sometimes they’re what’s just called de novo, when the sperm and egg go together, the instructions get mixed up a little bit. We do believe a lot of it came from a long time ago, when we were almost wiped out by sexually transmitted diseases. And those STDs were altering the genes when the conception, in other words, when the sperm went into the egg, the STDs were interfering. And causing the problem, so… I often joke, if you want to blame somebody. Blame your great-great-great-great-great-great-great-grandparents for, being a bit promiscuous, so… Dr. Deb Muth 00:15:31 Yeah, for being… having a little too much fun, right? Bob Miller 00:15:35 So, we don’t know for sure, but, you know, there are some that, But most of the SNPs that we get inherit from our parents. So, if you look at a child. And you look at the SNPs. 99.9% of the time, it came from one of the parents. Dr. Deb Muth 00:15:50 In identical twins, do they have the exact same identical makeup? Bob Miller 00:15:54 Yep, Dr. Deb Muth 00:15:56 But not in fraternal twins, correct? Bob Miller 00:15:59 No, no, those could be different, Jeff. Dr. Deb Muth 00:16:00 It could be different because they have different sacs, they’re not sharing that same genetic makeup. Bob Miller 00:16:04 Yeah, so keep in mind, both your mother and your father have, you know, the two And so you get one from one parent, one from another. Dr. Deb Muth 00:16:13 So… Bob Miller 00:16:14 Interesting situation. I had, 3, 3 boys. And, we were looking at an enzyme related to breaking down oxalates. Now, the mother and father each had one SNP, and that’s called heterozygous. Three boys, and they all come together, they’re Amish boys, they’re a lot of fun. And I looked at their genomes, and the one boy didn’t have any SNPs at all. And one had won. And the other one had two. Dr. Deb Muth 00:16:41 Interesting. Bob Miller 00:16:42 So, we don’t quite know how these things get handed off, but with the parents each having one, you could have a child with none, one, or two. So, the one, his ability to break down oxalates, which is fine. The other one was slightly impaired, and the other one was dramatically impaired. So, you can have 3 children, and it all depends what the parents have. Now, if a parent has a homozygous, or 2 copies. And the other parent has nothing. Every child will have one. Okay. If both parents are homozygous, that they both have two, Every child will have two. Dr. Deb Muth 00:17:19 too. Bob Miller 00:17:20 Yes, so that’s the way it works, but, you know, but it’s somewhat rare that both parents are homozygous on an enzyme, but it can happen. Dr. Deb Muth 00:17:27 Do we think that infections today, like Lyme disease or mold exposure, things like that, if the parent, the woman, primarily, I’m thinking, is pregnant, and she actively has these infections. Can those infections affect the genetics, kind of like a past sexual transmission did where we thought back in the day? Bob Miller 00:17:47 Yeah, I… I mean, I’m not that much of a geneticist to answer that for sure, but my thought would be no, that at conception, the pattern’s made. Dr. Deb Muth 00:17:55 Okay. And then that’s… that’s the hand you’re dealt. Bob Miller 00:17:58 Yeah. So, I tell people we have good news and bad news. The good news is we can compensate for the weakness. The bad news is we can compensate for the weakness. Dr. Deb Muth 00:18:09 That is so very true. Bob Miller 00:18:11 Yeah, we can’t, because I often get asked, so we’ll do some things now, and we’ll check my genes again, and they’ll be better. It’s like, nope. Dr. Deb Muth 00:18:18 Oh, – – Bob Miller 00:18:19 You gotta play the hands you’re dealt, so… Dr. Deb Muth 00:18:21 That’s right. Bob Miller 00:18:22 You can test your genetics… if you’re looking at the same enzyme, you can test it every year. It’s not gonna change. It’s like the blueprint. Dr. Deb Muth 00:18:30 It’s good and bad, right? It’s the one test you only have to do once in your lifetime. Bob Miller 00:18:34 No, unless, you know, like, our. Dr. Deb Muth 00:18:36 All the time. Bob Miller 00:18:37 Yeah, now our test looks at, called the Functional Genomic Analysis Test of your genomic Resource. We look at 220,000 steps. Dr. Deb Muth 00:18:46 Wow, that’s a lot. Bob Miller 00:18:47 That’s not all of them. Dr. Deb Muth 00:18:49 Right. Bob Miller 00:18:50 So, maybe in the next year, we’re gonna come out with our third version of the chip. And then, if someone wants to get those new things that weren’t on it, they’d have to repeat. But whatever we measured is gonna stay the same. Dr. Deb Muth 00:19:03 That’s a lot of SNPs to look at. Bob Miller 00:19:05 Keeps us busy. Dr. Deb Muth 00:19:06 But there’s still, but there’s still SNPs that we. Bob Miller 00:19:09 That we’d like to have that we don’t have, so… Bob Miller 00:19:11 We started out with version 1 on our genetic test, then we worked with version 2, and we’re already compiling a list of what version 3 would look like. So if somebody has our version 2, And we’re saying, you know what, it’d be nice if we could see these, well, then you’d repeat, but it won’t change what you already know, so… Dr. Deb Muth 00:19:29 Got it, got it. So, when you started out, and you started looking at the research of Lyme disease and chronic infections, which detox pathways are most important for people who struggle with those conditions? Bob Miller 00:19:43 Okay. You know what might make sense as we do a screen share, and I’ll actually show you the pathway. Does that make sense? Bob Miller 00:19:48 Alright, so… let’s see if I… let me just press the share… Dr. Deb Muth 00:19:52 Yep, you should just be able to press share. Bob Miller 00:19:54 And… number 2. Okay. Are we seeing the screen there? Bob Miller 00:20:01 Okay. Dr. Deb Muth 00:20:02 So, this is a map that we made. Bob Miller 00:20:05 And by the way, this is not… All-inclusive of all the things we look at, but we believe this is a core issue. So, where we’re going to start here, there’s something called the microglia. And the microglia are glial cells. They’re in the brain and the central nervous system. And they’re very interesting little creatures, because most of the time, and this is just a drawing of what they sort of look like. Most of the time, they’re in what’s called the M2 anti-inflammatory mood. What that means, these little guys pick up dirt, debris, Recycle them. Turns on an enzyme called interleukin-10 that’s anti-inflammatory. And just kind of does general housekeeping. And just kind of does general housekeeping. However, when a trigger comes along. However, when a trigger comes along. They… it’s the same glial cell, but it moves over to a very pro-inflammatory enzyme. A pro-inflammatory glial cell. And it triggers these 3 enzymes, Actually, these four. That are pro-inflammatory. Tumor necrosis vector alpha, Interleukin-6. NF Kappa B, Inos. Now, these create inflammation. So you might think, well, why is that good? Well, if you have some foreign invader, virus, bacteria coming in, parasite. If you didn’t have these guys coming to the rescue, you would just die of infection. So, these guys are your friend unless they’re your worst enemy. Because TNFA, and we’ll show you when we actually do a demo account, TNFA can be overactive. So, in other words, it over-responds. Interleukin-6 can be overactive. And if Kappa-B can be overactive. The INOS, and I’ll explain each of these as we go through a demo, can be overactive. Now, what that means is, you’re very good at killing virus and bacteria. But this is where autoimmune disease comes in, and just inflammatory conditions. Now, this is just speculation, but we think what happened is, as you know. Thousands of years ago, we didn’t have refrigeration, we didn’t have sewer, we didn’t have pure water, and we didn’t have antibiotics. So, if you made it to 40, you were an old-timer, because everybody was dying of infection. So, what we believe happened is, by what’s called natural selection, Having these overactive. A thousand years ago was to your advantage. Dr. Deb Muth 00:22:31 Hmm. Bob Miller 00:22:32 But now… We have pure water, we have refrigeration, we have sewers, we have antibiotics. But now we have environmental factors that are stimulating them. Now it’s to our disadvantage. And we’ll talk about that a little bit as it relates to the hemochromatosis genes and maybe the G6PD. Dr. Deb Muth 00:22:48 Yep. Bob Miller 00:22:49 Now, why are we becoming so inflamed? Let’s look at the triggers. Now, one of my, favorite expressions is. I was born all the way back in 1954. Dr. Deb Muth 00:23:01 And it was a different world back then. Bob Miller 00:23:05 These are some of the triggers. And we’ll get into these, but right now, high fructose corn syrup, And the high-fat diet. High fructose corn syrup only came about in 1968. So now we’re being exposed to high fructose corn syrup. Then… we didn’t have these, these viruses like COVID. Dr. Deb Muth 00:23:26 Yeah. Bob Miller 00:23:27 Now, there’s now pretty strong evidence that COVID Was actually, you know, made as a gain of function. It’s debated, and I’m not taking an opinion on it, but there’s some people who believe Lyme disease was also a part of experimentation. Dr. Deb Muth 00:23:40 Go. Bob Miller 00:23:41 Then we have molds, and it appears as though mold is getting stronger. you know, 20 years ago, when I was seeing folks, mold wasn’t on the radar. I would say 7 out of the 10 folks we speak to today have mold problems. Yeah, 20 years ago, we talked more about mold allergy being an issue versus mold toxicity being an issue. Right. So… I know some folks are, you know, speculating what’s happening, but one of the theories out there is that EMF is strengthening mold. I don’t know if you ever heard that theory, and I don’t… Dr. Deb Muth 00:24:13 I have. Bob Miller 00:24:14 I’m not claiming it’s true, but it’s an interesting theory. Then even, you know, your black mold from water-damaged buildings. Then our air pollution is getting worse. We’re getting more toxic metals. Dr. Deb Muth 00:24:26 You know, if we have a… Bob Miller 00:24:27 You know, we’re gonna look back someday and say, what were we thinking, smearing aluminum into our armpits? The, what were we doing putting mercury in our teeth? Then, you know, glyphosate. When I was a kid, there was no glyphosate. So, all of these herbicides and pesticides. Polychlorinated biphenols, And then EMF. So, we love our cell phones, you know, and I think unless you, or in the middle of the desert, or down in a cave, you’re being exposed to EMF somewhere. So, you know, we have our cell phones with us, we have, We have Wi-Fi, the towers are everywhere. And we don’t know long-term, but we may find that this can… this creates some inflammation. And I don’t know if you get any folks, but do you have any folks that have… are they EMF sensitive? Dr. Deb Muth 00:25:16 Oh yeah, we have a whole bunch of them. Bob Miller 00:25:18 Yeah, and then if you have any TBIs, So, plenty of things here. that will stimulate into the microglia, M1. Now, you could say, well. We’re all pretty much exposed to the same thing. Why do some people get hit harder than others? So here’s where we’re gonna start. There’s an enzyme called Nrf2 and RF2. And Nrf2 is the enzyme that senses when there’s inflammation. And turns on hundreds of anti-inflammatory enzymes. We’ll show when we do the demo, you can have genetic weakness on NERF2. And NERF2 inhibits and slows down microglia M1. supports M2. Now, if it’s not complicated enough, there’s an enzyme called KEEP1. And KEEP1 inhibits NRF2. And you can actually have gain of function on keep 1, that makes Keap 1 stronger. So… A lot of the people who land on my doorstep So… A lot of the people who land on my doorstep Both parents gave a mutation on KEEP1, making it overactive. Both parents gave a mutation on KEEP1, making it overactive. Dr. Deb Muth 00:26:31 Hmm. Dr. Deb Muth 00:26:31 Hmm. Bob Miller 00:26:32 Suppressing Nrf2, nerve 2 might be weak. So, nobody’s putting the brakes on, M1. And by the same token, Nerve 2 supports M2. Then there’s a process called mTOR and autophagy. mTOR stands for mammalian tard of rapamycin, the growth of new cells. And then autophagy, taking our dead cells and recycling them. We need a balance between the two of them. If we didn’t have mTOR, the sperm and the egg would never become the baby, the baby would never become the adult, we wouldn’t make new cells. But our cells are constantly, you know, the old cells dying off. Autophagy is where we take that debris from the cell and recycle it, just like a farmer Plows the crop under at the end of the year. The dead plant then becomes the fuel for the spring, your dead cell becomes the fuel for the spring, and that’s autophagy. So we’re gonna look back someday and say, what were we thinking? We give our animals growth hormones so they get fatter faster. Oh my. So, we consume those animals, and inventory runs faster. Now, for anybody who’s, You know, maybe above 40, 45 years old. Think back when you were 12, and what did girls look like? They were primarily flat-chested little girls. Now they look like 16-year-olds. Because environmentally, we’re jacking up mTOR. So, mTOR stimulates microglia M1, suppresses microglia M2. Probably 80% of the folks we visit with. This is the part of the problem. NRF2 is weak. mTOR is strong. Environmental factors come along. And this guy gets carried away. He doesn’t do that burst and move back. Stays here. We’re calling that How environmental factors create a locked-in, pro-inflammatory. and neurotoxic phenotype. In other words, once it starts, it just keeps… Feeding upon itself. Alright, so what happens now when microglia is overactive. it triggers these 3 enzymes, TNFA, N of kappa B, And interleukin-6. Each one of these can have genetics that make them run stronger. Then it stimulates an enzyme called NLRP3, Which makes what are called inflammasomes. Now, guess what inflammasomes can be? Your best friend or your worst enemy? Because they will, if you’ve got, again, a virus or bacteria, or possibly even some bad cells in the body. They will zap them. Well, that’s good. Unless it’s overactive. Unless it’s overactive. And then what it does, through interleukin-1 beta, makes excess glutamate. And then what it does, through interleukin-1 beta, makes excess glutamate. Anxiety, gut inflammation, OCD, ADD, autism. And, you know, glutamate, we’ll talk about that a little bit, but glutamate makes you intelligent, highly motivated go-getter. but can also be excitatory. And then, look what it does. Let’s see, do I have the drawing tool here? Yes, I do. Okay. So, it comes down through here, Makes the glutamate. Comes back up through here. through the ADORA 2A enzyme, Then we’ve got a feedback loop that feeds upon itself. Then, through interleukin-18, we make histamine. and mast cells. And then through histamine receptor site number 1, we come back and spin it. And now you’ve just got this spinning feedback loop. So, the glutamate will make you anxious, the histamine will give you allergies and make you anxious. And you’re allergic to everything, and you’re feeling horrible. Now, it doesn’t end there, Dr. Dad. It then goes on to make something called gast dermins that creates pyroptosis, where it actually starts punching a hole in the cell membrane. And you’re only going to be as healthy as your cells are. Just a little background. You know, we’re made up of trillions of cells, and each one of them has what’s called a lipid bilayer, made from lipids, which comes from fats. And you’re only going to be as healthy as those membranes are. So that’s why we coined an interesting phrase. Cellular CPR. Construct the cell. Protect the cell. And restore the cell membrane. And we believe that’s going to be revolutionary in the functional medicine world. So… It’s not hard to figure out that if you start punching holes in the cell membrane, that’s not a good thing, okay? Bob Miller 00:31:22 Now… There’s an interesting molecule called NAD. Thicotide adenoside dinucleotide. And anybody who’s in the, you know, listening to the health podcasts and things, they’re… They’re, they’re learning about NAD. And I’m going to show you a chart later, all the good things that NAD does, but For the most part, it helps what’s called sirtuins. And sirtuins are quite interesting. If anybody’s looking at longevity. The sirtuins is where they’re looking at.Because sirtuins turn on good things. Turn off bad things. And I’ll show some charts on that later. So for right here, this sirtuin uses NAD, to slow down NF-kappa-B. CERT 2 uses NAD to slow down an ORP3. So, if we’ve got genetic weakness on these, or we don’t have enough NAD, We don’t hold this pathway back. Make sense? Dr. Deb Muth 00:32:24 Yeah, makes perfect sense. Bob Miller 00:32:25 Now, I’ll show this a little bit later. So, people are like, oh, well, I’m gonna start taking some NAD. Dr. Deb Muth 00:32:31 Right. Bob Miller 00:32:32 And there’s functional doctors who give NAD intravenous. It was just this morning, I was talking to a woman who said, Oh my gosh. I went and got intravenous NAD, and it took me a month to recover from that. Dr. Deb Muth 00:32:45 Hmm. Bob Miller 00:32:46 what happens is, and I’ll show this in a little more detail, there’s an enzyme called CD38, that’s stimulated by NF-kappa-B. And it takes NAD, To make intracellular calcium. that stimulates NLRP3 and actually makes things worse. So, if we have this guy upregulated, and I’ll show a chart what does that. taking NAD will make you worse. Again, when I go into the software, I’ll show you that whole pathway, so… I would encourage people, you know, just don’t go out and start taking massive amounts of NAD, you know, stick your toe in the water, see how you do. Because everything you’ve heard about, how good it is, is true, unless this guy says, oh, thank you very much, let me make more inflammation. Now, this might be part of our innate immune system, that if we have some pathogen that’s gonna kill us. By golly, we want that to happen. But if this is happening by environmental factors, Then it’s detrimental. So the immune system that protected us a thousand years ago now might be turning on us because of the environmental factors that we showed earlier. All right. Then there’s an enzyme called PARP that’s NAD-dependent, and that actually repairs strain breaks in your DNA. Now, the next thing that happens… is there’s an enzyme called NADPH oxidase that gets stimulated. and something called INOS. Now, I’m sure most people know about nitric oxide. It’s a gas that dilates your blood vessels. That’s why sometimes they’ll even give people drugs, nitroglycerin, to boost their nitric oxide. That’s why people are doing beetroots and other things to boost their nitric oxide. But there’s an OS3 enzyme that makes the nitric oxide that’s good for blood flow. But there’s an INOS That makes nitric oxide to kill pathogens. probably might be the third or fourth time I’ve said this. That’s a good thing, unless it isn’t. So, if it’s killing some pathogen, great. It was just misfiring. it combines… With superoxide that’s made by this enzyme, and makes something called peroxynitrite, which is one nasty free radical that chews you up and spits you out. So, the NOx enzyme, NADPH oxidase, uses NADPH, To make this free radical called superoxide. If we have time, we’ll get into it. NADPH is what your body needs to recycle your antioxidants.So, I coined the phrase, the NADPH steel. Where the NOX enzyme takes this very important NADPH, And rather than being useful, makes superoxide. Now, again, is that fine if you’ve got some bacteria to kill? Of course. But if it’s just chronically running, it’s just making all this chronic inflammation. Then it makes something called hydrogen peroxide. And we need to clear hydrogen peroxide by 3 enzymes, catalase, thyroid reduction. And glutathione peroxidase. If we have genetic issues on here, or we don’t have the cofactors. There’s something called the Fenton reaction, discovered in 1895 by Dr. Fenton. Where hydrogen peroxide combines with iron to make what are called hydroxyl radicals. And guess what they do? They create lipid peroxides, That damages your cell membranes. Now, again, the body’s pretty darn amazing. We have glutathione, And here’s where your body’s taking glutathione and recycling it. But look who’s needed to recycle it. NADPH. So, if this guy up here is chewing it up, We don’t recycle our glutathione. And then an enzyme called glufon peroxidase 4, Takes this damaged lipid and repairs it. So, here we’ve got this protecting, we want to protect it by not having this happen. But then we also need this guy to do the restoration. So, there’s a lot that can go wrong in here, Dr. Deb. Dr. Deb Muth 00:37:07 There’s a lot that could go wrong. And I can imagine some of my listeners are thinking that lipid peroxidase, is that the same thing as what they’re thinking of when we talk about lipids and cholesterol? Is that the same process that’s happening there? Bob Miller 00:37:22 Well, no, no, the lipids can be used to make cholesterol, but here we’re talking about where they’re going to build the cell membrane. And they’re being… and they’re being, destroyed. If anybody would like to see a visual representation of this, just go on YouTube. And type in, ferrooptosis Animation. cool little video, it’s about 3 minutes long, and it shows the lipids coming over, being oxidized, and now GPX4 fixes them, so… YouTube, Pharaoptosis Animation, cute little video. It’s just that really… Shows vividly what we’re… what we’re talking about here. Now, this is… Dr. Deb Muth 00:37:59 And so this is very common, too. Like, a lot of people do hydrogen peroxide IVs. Dr. Deb Muth 00:38:04 And so, if somebody doesn’t know their genetics, they could have a problem with doing those, just like they could doing the NADHIVs, correct? Bob Miller 00:38:13 Sure, yeah, yeah, yeah. So, I’ve talked to so many, you know, of course, the hydrogen peroxide kills pathogens. I mean, that’s what it does. So… but I’ve spoken to so many people that said. I had one client that said they’ve never been the same after having one hydrogen peroxide infusion. Dr. Deb Muth 00:38:30 Interesting. Bob Miller 00:38:31 Yeah. So… it can be… I see why people use it, because it. Bob Miller 00:38:36 pathogens, But on the other hand. And now’s a good time to speak about… I don’t have it on here, but there’s a, there’s an enzyme called the HFE gene. And that is what causes you to absorb iron. And there’s mutations in it that cause something called hemochromatosis. Were you overabsorb iron? Now, true hemochromatosis is when both parents give you a mutation. But there’s now growing evidence even a heterozygous can cause a little bit more iron absorption, not to the human chromatosis point, but overabsorption. So, if you overabsorb iron, And you have too much hydrogen peroxide that’s not cleared, All kinds of inflammation. Now, what’s happened is sometimes this inflammation Will damage the red blood cells. And some well-meaning doctor says, oh, you need some iron. And they take iron and it makes it worse. So, can’t tell you how many people I’ve said, you’ve got the overabsorption of iron, and they say, well, that can’t be right, because I’m low in iron. Well, that could be because it’s being chewed up here. Dr. Deb Muth 00:39:40 Sure. GPX1 and TXN turn it into, to water. The, catalase turns it into water and oxygen. Dr. Deb Muth 00:39:58 Now, I see a lot of my clients who have mutations or SNPs on that GPX gene, on that glutathione gene. And they really struggle to clear a lot of their toxins. Bob Miller 00:40:12 Sure. Dr. Deb Muth 00:40:14 Yeah, absolutely. Well, GPX4. Bob Miller 00:40:18 is what, repairs, but you can see GPX1 Is what uses glutathione. To turn hydrogen peroxide. So, but it all depends upon having enough glutathione. Dr. Deb Muth 00:40:30 Yeah. Bob Miller 00:40:31 Well, guess who controls making a glutathione? Dr. Deb Muth 00:40:34 Nerf 2. Bob Miller 00:40:37 So, if you have a keep one weakness, or strength to two… I’m sorry, keep one is too strong. Nrf2 is too weak. You don’t make glutathione. So, when a lot of people do that, it’s like, well, I’m gonna take glutathione. Dr. Deb Muth 00:40:51 Right. Bob Miller 00:40:52 And some do great, and some do poorly. You know, because… and I’ll show this on one of the other charts. You can see here that the, The glutathione has to be recycled. And if we don’t recycle it, it actually turns into superoxide free radical. So… NADPH are the cofactors, For taking the oxidi… here’s oxidized glutathione, here’s reduced. So, this is a good glutathione. After it does its job, you can see it becomes oxidized.We need to recycle it. Well, if we have weakness on the enzyme that does that, or a weakness in Nrf2, or not enough NADPH. The oxidized glutathione never gets recycled. So, I’ve talked to a lot of people who said, oh, glutathione made me so sick, and say, well. Dr. Deb Muth 00:41:43 Yeah. Bob Miller 00:41:44 You need it, but you need to recycle it. Dr. Deb Muth 00:41:46 Can you speak for just a brief moment, too, about MTHFR? That is a very popular gene, it’s all over social media as the major gene, but can you speak to a little bit about that, and how that fits into this whole process of things? Because it is just such a small piece. Dr. Deb Muth 00:42:04 understanding genetics. Bob Miller 00:42:06 Yeah, to be honest, it drives me nuts. Dr. Deb Muth 00:42:08 Me too. Bob Miller 00:42:11 Alright, so… You know, there are people on social media I won’t say what I think, I’ll be kind. But… But the, And, you know, they might mean well. But they talk about, if you have MTHFR and COMT and PEMT, that’s… oh my goodness, that’s horrible, and we’ll fix that for you, and you’ll be fine. Bob Miller 00:42:36 it just irritates me to no end. And it really could get anybody who’s doing this legitimately in trouble. I mean, I’m afraid someday, you know, there might be some cracking down on this kind of nonsense. Now, to answer your question about MTHFR. Dr. Deb Muth 00:42:51 I mean, it really is, but I’ll tell you what, why don’t we hold that thought until I go to another map and I can actually… Okay. Bob Miller 00:42:56 But the real… the cliff notes is the MTHFR puts a methyl group on your folate, which is needed, but it has gotten way, way, way too much attention. And people learn they have MTHFR, and they start taking a multivitamin with methylfolate, then they take a B vitamin with methylfolate. Dr. Deb Muth 00:43:13 And they’re pushing it too hard. Bob Miller 00:43:15 Yeah. So I can’t tell you how many people I’ve helped by saying, stop it. Dr. Deb Muth 00:43:20 Yeah, take less of it. Bob Miller 00:43:21 Take less of it, yeah. So, yeah. Yeah, there’s a… If somebody, say, ranked the enzymes at their level of importance, MTHFR might be 40 or 50 on a scale of 100, you know. Keep one Nerf two. big deals. Dr. Deb Muth 00:43:40 deals. Bob Miller 00:43:41 NQO1 that I didn’t even talk about yet, NQO1, takes your, NA… your NAD goes into NADH, To make electrons for the electron transport chain. you need NQ01 to bring that back. If that’s not working, and I’ll show you on the NAD map how disastrous that can be. Now, the next piece is here, and I think You know, if you talk to any school teachers and say, if you’ve taught for more than 10 years, how are the kids today? Every one of them says, more ADD, ADHD, more autism. Just look at human beings, we’ve never been so agitated. You know, everybody, and it might be a social media thing, but people take a position on something, and if anybody doesn’t share that position, they view them as the enemy. Dr. Deb Muth 00:44:29 And it’s kind of scary what’s happening to us. Bob Miller 00:44:33 So, we can’t agree to disagree anymore. We see anybody who has a differing opinion as the enemy. And, you know, there was… there’s people that didn’t have Christmas dinners together, because they had political differences, like… Dr. Deb Muth 00:44:44 Excuse me. Bob Miller 00:44:45 can’t you put your political differences aside to have Christmas together, you know? Dr. Deb Muth 00:44:49 Right? Bob Miller 00:44:50 become that, you know, no matter what your position is, and I’m not saying anyone’s right or wrong, I’m just saying. You know, in the old days, they used to say that the Republicans and Democrats in Congress would argue policy and then go have dinner together. And now everybody’s all up in arms, angry. Dr. Deb Muth 00:45:05 Yeah. Bob Miller 00:45:06 So… There’s likely multiple reasons for that. But let me show you one of them. That, you know, to what degree this is… very important, we don’t know, but I think We’re beginning to believe this is very important. So, there’s something… there’s a neurotransmitter called GABA. And God buys the don’t worry, relax, be happy. Chill. Okay. Dr. Deb Muth 00:45:31 Nobody has enough of that anymore. Bob Miller 00:45:33 Well, yeah, you’ll be surprised what I’m gonna show you. So, let me see if I can find a, Let me see if I can find the right slide here. Let me look for it here. So, there’s something called a GABA receptor site. And here you can see… This is a neuron, and this is where you, The neuron normally is excitatory. However, there’s normally low chloride in the neuron. Dr. Deb Muth 00:46:09 Hmm. Bob Miller 00:46:10 So, GABA itself is neither relaxing. For excitatory, all GABA does, it opens up what’s called a chloride channel. And then chloride, which has a negative charge, will flow into the neuron. Follow me there? Dr. Deb Muth 00:46:26 Yep. Bob Miller 00:46:27 And as it does, it changes this from a positive charge to a negative charge, And it’s relaxing. and inhibitory. Dr. Deb Muth 00:46:34 Hmm. Bob Miller 00:46:36 Now, on the other hand, there’s enzymes called NKCC1, That will push chloride in. and KCC2 that will bring chlor… oops and bring chloride out. And then there’s a sodium channel. And, sodium has a positive charge. And glutamate will push that in. So, as long as this is happening. And GABA says, receptor sites, open, chloride goes in, Chill. However, If NKCC1 Pushes extra chloride in. KCC2 doesn’t pull it out. and GABA hits the receptor site, the GABA comes flowing out, Sodium comes in, And now it’s excitatory. So Gabba didn’t change. GABA just opened the receptor site, that’s all it does. Dr. Deb Muth 00:47:33 Yeah. Bob Miller 00:47:34 But it’s the chloride balance that’s going to determine whether this is relaxing or not. Now, these are the things that go along with when they lose that KCC2 or gain NKCC1. Pain and sensitivity, burning electrical, neuropathic pain. Normal touch hurts. Sound and light sensitivity. Tinnitus can flare. Headaches and migraines. Seizure tendency. Body jolts. Spasticity, cramps, stiffness, startle reflex. Trouble falling asleep, non-restorative sleep. Anxiety, stress, reactivity, that’s what we have now. Hyperarousal, panic-like surges, irritability, racing thoughts. Brain fog, slowed processing, working memory slip-ups. Mental fatigue. Episodes of racing hearts, sweaty palms, guts on edge. Those are all the things that happen when this GABA switch occurs. Now, here’s what happens, and this is what I’m going to be presenting at an autism conference. When you have a newborn, they need that NKCC dominant to develop. By early childhood, it should… or, sorry, early adulthood. we should move over to the KCC dominant, that’s the taking the chloride out. Nice-looking 25-year-old boys, functioning very well. However, when we get microglia M1 upregulated. Because of environmental toxins, processed foods, Tylenol, aluminum. they stay in NKCC1 dominant, and there’s ADD, ADHD, Autism, the whole spectrum. because… They’ve not moved over to the… They’ve not moved over to the KCC2. And again, this is caused by… Environmental factors. Stimulating the microglia. And then, interleukin-1, interleukin-18 weakens KCC2, interleukin-1 beta, Strengthens NKCC1. high chloride. We open up the chloride channel, In Rebell Excitatory. So, I think when, When the pediatricians get ahold of this, they’re going to be very excited to know that This could be why we’re seeing such a rise, and not just autism, but ADD, ADHD, anxiety, the whole shit mess. Dr. Deb Muth 00:49:58 thing. Bob Miller 00:49:59 Yeah, so… and you can see NF-kappa-B stimulates that. These stimulate it, and I think that’s why everyone’s getting so anxious. Now, there’s a little bit more to it, and we’ll get into this when we look at some of the maps, but… The, the glutamate, Which is excitatory. will stimulate the NMDA receptor, make more glutamate, And glutamate will inhibit KCC2. And then we also need an astrocyte To, take both ammonia And glutamate, and… Turn them back into glutamine. And I’m going to talk to you a little bit about arachidenic acid, and if we have too much arachidenic acid. or TNFA is upregulated, that doesn’t happen. Ammonia goes up, and there may be multiple reasons for this, but this is a reason why some of the autistic kids do flapping. Dr. Deb Muth 00:50:49 Hmm. Bob Miller 00:50:50 Because they’re not clearing their ammonia. And you can tell if somebody has high ammonia by… they get that old person smell, you know. Dr. Deb Muth 00:51:00 Yup. Bob Miller 00:51:01 your vehicle cycle’s not taking out the, the ammonia. Now, last pathway here. There’s growing interest in mast cell activation. So, back here, we talked about peroxynitride. And that will stimulate mast cells, and those are white blood cells that are your best friend, unless they’re your worst enemy. Then it’ll make histamine. And there’s enzymes called histidine decarboxylase that’ll make more. Dr. Deb Muth 00:51:28 I’m sure everybody’s heard of DAO, the enzyme that degrades histamine. Yep. Bob Miller 00:51:31 We can have genetic weakness, we don’t make that. There’s an enzyme called histamine and methyltransferase, That, That breaks down the histamine. Then if we don’t do that, it’ll get stuck in the histamine receptor site. And then it’ll make something called, renin. Which will cause angiotensinogen to turn into angiotensin. One, that turns into angiotensin II,And that’s where people make aldosterone, where they’ll get the, The swollen ankles and high blood pressure. But interestingly, there’s an enzyme called ACE2, that takes this guy and turns it into angiotensin 1-7, Which is anti-inflammatory and also inhibits… TNFA. Now, you can have weakness on ACE2, But… and anybody’s saying, that sounds familiar? Dr. Deb Muth 00:52:25 That’s where COVID comes in, using ACE2. Bob Miller 00:52:28 And now we just found there’s literature that if you get COVID long enough, it can actually make ACE2 not be able to work as well. So look what it does. It comes down here, stimulates the NADPH oxidase, More superoxide. More peroxynitrite. And we’re on a cycle here. We’ve actually named this the Home Cycle Hypothesis, the proposed feed-forward loop. That just keeps feeding on itself. All being caused by… Primarily, The environmental factors. But hitting those who have genetic weakness the hardest. That’s why. Dr. Deb Muth 00:53:08 To the people. Bob Miller 00:53:09 Don’t live in a moldy house. One person is sick as can be, and the other person says, well, you must be imagining things, because I don’t feel anything. Dr. Deb Muth Yeah. Same thing with long haul, right? Two people can both get sick, one gets sick and never seems to recover, and somebody else gets sick, and they have absolutely no problems with it at all. Bob Miller 00:53:30 Sure. Well, think about it, if you get COVID, and ACE2 is weak, and some of this other stuff is going on. This thing just starts feeding upon itself. Dr. Deb Muth 00:53:38 Keep creating more inflammation, more complications, nothing’s calming down. Bob Miller 00:53:43 Yeah. Now, you, you ask about, MTHFR. So, this is the, this is the, the software called Functional Genomic Analysis. There’s a demo report we have. So, let’s talk a little bit about, MTHFR. So, we actually have a map called a methylation map. Now, what happens is, when you do your saliva test, you, you know, you spit, you put some saliva. in a collection kit, goes to a lab, takes out the DNA data, sends it to the computer, and now you can actually see it visually. Okay. So, it’s gonna take a second for this, data to load up, it’s, and each of these Circles, each of these ovals, is an enzyme. And the data gets loaded up to see where it is. So, until it gets loaded up here, I didn’t preload this. There it goes. So… The primary thing about methylation is There’s a nasty substance called homocysteine that, if it’s too high, can really be detrimental. The body takes methylfolate, and combines with methyl B12, To bring this back up to methionine. And then through the MAT genes, we make SAMI, S-adml methionine. Which is involved in so many processes. Then after it does its thing, it turns back into homocysteine. And this thing needs to keep spinning around. That’s why, you know, it’s a good idea to keep homocysteine at, do you have a number that you’d like? 7, 8? What do you like for a number? Dr. Deb Muth 00:55:24 Yeah, I like mine below 7. Bob Miller 00:55:26 Yeah. So if the homocysteine goes too high. It, caused all kinds of problems. So, here’s where you ask about the MTHFR. So, here you can see on this individual. I click on MTHFR, and you can see it comes up here, here’s the C677. And you can see here where it says, variants. I’ll… I’ll draw in case somebody’s having a hard time seeing that. So, you can see there’s nothing in there. That means there’s no genetic mutations. If one parent would have given a mutation, there’d be a 1. If both parents did, there’d be a 2. Now, here’s why Yes, methylation is important, I’m not saying it isn’t important, but look at this MTHFRC677. In my software. Only 42.5% of the population does not have a mutation. 44.7% have won. 12.9 have 2. So, this isn’t some rare, oh my god, I’m gonna die… Kind of thing, yeah. Dr. Deb Muth 00:56:27 Right. Bob Miller 00:56:28 So, And then what happens is that, and again, I’m not dismissing methylation, I… we could do a whole show on methylation. Bob Miller 00:56:36 get it. But I think that what people are doing is they’re, they’re learning about MTHFR, they get it measured, they panic. They start taking massive amounts of methylfolate, which many times is to their detriment. Dr. Deb Muth 00:56:50 Well, it’s… and isn’t it true, too, with MTHFR, like, you have to also look at MTR, MTRR, and the more we stack up of those, the more complicated than MTHFR can be. It’s not… it’s not as simple as just saying MTHFR 677 versus 1298. It’s more complex than that, kind of like what you’ve already shown with some of the other things. There’s more to it than just that one little sliver. Bob Miller 00:57:17 Oh, sure, well, let’s take a look. So, remember I said there’s a cofactor? One of the cofactors is called FAD. Just a Bob Miller observation, that’s all. But when people have trouble with their riboflavin and they don’t have enough FAD, They’re doing much worse than people who have just a C677. So, right here, you could have perfect C677th. And if you don’t have the cofactor, it’s not gonna work, okay? Dr. Deb Muth 00:57:48 And as you said, there’s an MTR enzyme. Bob Miller 00:57:51 that takes methylfolate and methyl B12, to spin it around. So, here on this individual. here’s your… here’s your B vitamins, or I’m sorry, your B12s. There’s an enzyme called TCN1 that takes it from the stomach into the blood. Then there’s other enzymes that take it from the blood into the tissue. And if you’re having trouble here. Well, then you’re not going to have this working, so… Even if you don’t have MTHFR, And you have MTR, like this, no, I’m sorry, this person doesn’t. But they have the MTRR, and then they don’t have enough B12, this isn’t gonna work, aside from that. And then there’s a middle pathway. And then there’s enzymes called the MAT1. they take the methionine to the salmon. If that’s not working, we stick… we get stuck in methionine. So, it’s, it’s not just an MTHFR. And then, one of the things that people forget about. is through these CBS enzymes and CTH, We make cysteine, which is needed to make glutathione. The master antioxidant. So, it really is that… I call it the, The 3D chess game played underwater. Dr. Deb Muth 00:59:07 It really is. I mean, I see people who have CVS, COMT, glutathione, MGHFR genes. And some of them function just fine. Like, they have Like, I look at this person and I’m like, oh my gosh, I don’t know how they’re functioning because they’re double mutated on so many pathways, but yet they don’t have a lot of symptoms, they don’t have a lot of complications. Somehow their body has figured out a way to adapt to what it has so it can stay alive and it can function at a high functioning level. Bob Miller 00:59:36 Yeah, and they may be, you know, eating right? Yeah. Staying out of a moldy house. reducing stress. So, it’s diet, it’s stress, it’s genetics, environmental factors. So, yeah, we can’t just say somebody’s gonna be good or somebody’s gonna be bad. You know, some people get scared, oh, I got all these, it’s like, well… Bob Miller 00:59:56 Are you living in a moldy house? You know, and if you live in a moldy house and your glucuronidation pathway doesn’t do well, or if you’re, you know, a smoker, or you’re constantly eating junk food, I mean, all. Bob Miller 01:00:07 things come together. Although, you know, when we focus on genetics, we’re well aware that this is just a piece of it. You know, you could have identical twins, Genetically, and if one… Is exposed to mold and smokes and drinks and stressed out. They’re gonna be a whole lot sicker than their sibling. Bob Miller 01:00:28 Yep. Dr. Deb Muth 01:00:29 Yeah, it’s that concept of taking twins, and one gets raced with one family, and one gets raced with another family, and they don’t have the same… problems that… that each other have, you know? It’s a very unique situation, we don’t think about that enough. Bob Miller 01:00:44 Alright, so again, genetics loads the gun, environment pulls the trigger. So, if you’ve got a loaded gun, but you don’t have the triggers, you’re okay. Dr. Deb Muth 01:00:53 Yeah. Bob Miller 01:00:54 Yeah. So, remember I said I was going to talk about NAD? So, here’s NAD, and what it does, it turns into NADH. And what NADH does, it, Comes down this pathway, what’s called the electron transport chain. And that makes your ATP, that’s your energy. So, if this wasn’t working, we wouldn’t be alive, because we wouldn’t have energy. So it donates an electron, that’s why it’s called electron transport chain. So, we need NAD, To make this, to make the energy. But remember I said that NQ01, this would probably be, like, on my top 10 list of… Bob Miller 01:01:36 Much more important than MTHFR. This one takes NADH back to NAD. If we’re stuck over here, We’re low in this NAD+, But what happens is, NQO1 also provides CoQ10. And CoQ10 Is what’s needed for the electron transport chain to flow. So if we get too many electrons up here. And they don’t turn them into energy. They make a nasty free radical called superoxide. Okay. Now, NAD plus also makes NADPH, And that is needed. Remember I said we need to recycle our antioxidants. So, if we have a problem with FAD from riboflavin. Yeah, we don’t have enough NADPH, Glutathione’s not getting recycled, and you’re gonna be inflamed. And you take glutathione, you’ll feel worse. There’s another enzyme called thimoredoxin. Same thing, needs NADPH and FAD. And same way with your nitric oxide, there’s an enzyme called NOS3, That makes the nitric oxide that dilates your blood vessels. And if we don’t have enough NADPH or fat, You’re gonna make superoxide. Rather than nitric oxide. Now, remember

This month, Malachi, Logan, Danya, and Jeff reflect on their church's sermon series "Called." They explore the tension between what we feel in a given moment and what we know to be true, and how that gap shows up across every area of life. They also dig into what it really takes to heal from past experiences and grow as people: a level of honesty that doesn't come naturally to any of us.You can check out our content on YoutubeAs well as check out our church on Instagram and at KCC.net

TWL 2026 - Ep 27: Dai on this hill - feat. Dai HenwoodThere's no way you could enjoy this as much as Will and Brad did, but it's one of the great Team List Tuesday LIVE episodes courtesy of the long-awaited return of Dai Henwood ONZM! There's Dai's Sydney mini Magic Round, viewers watching us in the bath, recruit watch with Grant Anderson and Will Warbrick, Kane Evans' moving interview, a surprisingly big team list drop and a preview of Saturday's clash with the Sharks, another PlaceMakers Warriors legend profile and more No Ugly giveaways. Join us as a paid subscriber on Substack at https://www.thiswarriorslife.com/Brought to you by the Warriors-mad legends at Kingz Container Crew

TWL 2026 - Ep 26: Ill Telecommuncation feat. Jason ParisA special bye week treat for TWL as One NZ CEO, Warriors superfan and social media assassin Jason Paris stops in for an in-depth chat about what makes the Warriors' record-breaking partnership with One NZ tick, the ups and down of COVID and the 'Up the Wahs' phenomenon since, the infamous Twitter incident, One NZ and the prospect of a South Island NRL club, and the balance of being a passionate supporter and a chief sponsor. Join us as a paid subscriber on Substack at https://www.thiswarriorslife.com/Brought to you by the Warriors-mad legends at Kingz Container Crew

TWL 2026 - Ep 25: Signed, Sealed, DeliveredFonz, Will and Brad get together for a rare pre-record and break down the barnburner against the Panthers and dust off the mailbag to answer listener questions: Metcalf v TMM, Ali v Rocco, hooker depth, Capewell re-signing + much more. Join us as a paid subscriber on Substack at https://www.thiswarriorslife.com/Brought to you by the Warriors-mad legends at Kingz Container Crew

TWL 2026: Ep 24 - Half The World Away feat. Grant RovelliWill caught up with Grant Rovelli to walk through the underrated playmaker's rugby league journey, which took him from Mackay to Sydney Roosters, onto a career-defining stint with the Warriors and a boyhood dream realised at the Cowboys, before finishing back in Mackay. Warrior #127 also provides his thoughts on the current team's trajectory and comparisons to the overachieving 2007-08 combination that he was such a vital cog in. Join us as a paid subscriber on Substack at https://www.thiswarriorslife.com/Brought to you by the Warriors-mad legends at Kingz Container Crew

TWL 2026: Ep 23 - Fix Up, Look Sharp feat. Sam AckermanVeteran NZ league reporter Sam Ackerman joins Will and Brad to break down the win over the Dragons and take a LIVE look at the Round 13 team list ahead of the Warriors' top-of-the-table blockbuster against the Panthers.Plus an RTS tribute following his injury blow, the ongoing TMM vs LM debate, another NO UGLY Salty giveaway and an Aussie journeyman for this week's PlaceMakers Warriors Legend, and some great insights from Sam after a quarter of a century in the NZ sports media game. Join us as a paid subscriber on Substack at https://www.thiswarriorslife.com/Brought to you by the Warriors-mad legends at Kingz Container Crew

TWL Podcast 2026: Ep 22 - Knee DeepThere's a waka-load to cover in this Team List Tuesday LIVE ep - so Will, Fonz and Keith will do their best to unpack a storyline-laden Magic Round foray, where Tanah's injury, Luke's dramas and Te Maire's form leaves the Warriors; State of Origin (non) selection; and a fascinating team naming into a preview of the Rd 12 clash with the Dragons. Plus another NO UGLY Salty giveaway and a poignant PlaceMakers Warriors legend. Watch this episode on YouTube: https://www.youtube.com/watch?v=naKGdNw61nsJoin us as a paid subscriber on Substack at https://www.thiswarriorslife.com/Brought to you by the Warriors-mad legends at Kingz Container Crew

TWL 2026: Ep 21 - Use Your IllusionTWL 2026: Ep 21 - Use Your IllusionMike Minogue joins Will and Brad LIVE! from Brisvegas ahead of today's mega blockbuster between the Warriors and the Broncos at Magic Round.Watch this episode on YouTube: https://www.youtube.com/watch?v=hyiHpXtwd24Join us as a paid subscriber on Substack at https://www.thiswarriorslife.com/Brought to you by the Warriors-mad legends at Kingz Container Crew

It's bye week, but Will and Brad are still putting in the reps LIVE! on Thursdee afternoon with some No Ugly Salty to give away to our lucky viewers, the next edition of TWL's PlaceMakers Warriors Legends - and some commentary on the reports around Luke Metcalf that exploded all over our feeds last night. Watch this episode on YouTube: https://www.youtube.com/watch?v=Getq0mkm29YJoin us as a paid subscriber on Substack at https://www.thiswarriorslife.com/Brought to you by the Warriors-mad legends at Kingz Container Crew

This week on the Mezzanine Floor, Jeff Turner-Hayes joins the crew to unpack KCC's sermon series, Redeemed. Together, they explore what authentic faith really looks like, how to engage others with honesty and intention, and why true authenticity begins with our relationship with God.You can check out our content on YoutubeAs well as check out our church on Instagram and at KCC.net

TWL 2026: Ep 18 - Dancing on the Ceiling feat. Sam Hewat For a bye week treat, Will and Fonzie are joined by Sam Hewat of Sport Nation Warriors commentary and 'Running it Straight' show fame. There's a wrap of the Round 9 win over the Eels and an overview of what's got the Warriors to where they are now and how far we think they can go - followed by a robust discussion about the line-up that can take us the furthest in 2026 and the retention puzzle.Watch this episode on YouTube: https://youtu.be/qGg_sXx7W_sJoin us as a paid subscriber on Substack at https://www.thiswarriorslife.com/Brought to you by the Warriors-mad legends at Kingz Container Crew

This week on Truth to Power, we bring you a community conversation focused on a 2026 Kentucky Legislative Session Review with respect to Housing & Energy Bills. This EveryHome webinar was held on Monday, April 28th at 1pm (monthly on 4th Tuesdays at 1pm - on May 26th, it'll be an expert from Union of Concerned Scientists on Urban Heat Islands). Stay tuned if you're curious about what happened to housing and energy bills during the 2026 Kentucky legislative session! Forward Radio's proud community partner, the Metropolitan Housing Coalition and guests panelists from Kentucky Conservation Committee, Coalition for the Homeless, and Kentucky Resources Council discuss what did and didn't pass, and the implications for Kentucky's housing and energy future. Speakers include: Sarah Pierce, MHC; Ashley Wilmes, KRC; Lane Boldman, KCC; George Eklund, Coalition for the Homeless, Director of Education and Advocacy; Byron Gary, KRC - Utility Disconnection Stories: Website for Stories: https://sites.google.com/view/leavetheheaton/story-lounge Story Collection form: https://docs.google.com/forms/d/12wP8GzR0bx2JgPYkOdMMaw-RnUryeXt2lVy4rgoWgks/edit Message Line: (859) 379-5306 - KRC's Model Guidance on Data Centers: https://kyrc.org/krc-releases-data-center-model-guidance/ - League of Women Voters reports on legislative transparency: https://www.lwvky.org/how-can-they-do-that - New study on energy burdens in Kentucky: https://aclc.org/wp-content/uploads/2026/02/Lights-Out-Report-Final.pdf - Email Lane Boldman if you're interested in nuclear field trips: director@kyconservation.org Truth to Power airs every Friday at 9pm, Saturday at 11am, and Sunday at 7pm on Louisville's grassroots, community radio station, Forward Radio 106.5fm WFMP and live streams at https://www.forwardradio.org

TWL Podcast 2026: Ep 17 - Capital PunishmentWill and Brad with another LIVE Tuesday episode, recapping the Warriors' sleeves-rolled-up win over the Dolphins and bringing you what shapes as intriguing team list reveal ahead of Saturday's road trip to Parramatta.Meanwhile, an Eels junior features in the latest instalment of our PlaceMakers Warriors legends, and we've got the first of a weekly giveaway for you thanks to No Ugly.Watch this episode on YouTube: https://www.youtube.com/watch?v=Uwauy5KTmuAJoin us as a paid subscriber on Substack at https://www.thiswarriorslife.com/Brought to you by the Warriors-mad legends at Kingz Container Crew

TWL 2026 - Ep 15: Parallel Three-quarter LinesWill, Brad and Fonzie are comin' at ya for another LIVE! Tuesday episode, recapping a patchy Warriors win over the Titans and bringing you a fascinating TLT ahead of the Anzac Day clash with the Dolphins.Meanwhile, there's club news to touch on, more selection debate as the backline picture continues to get more clouded, and a Wellington product in the latest instalment of our PlaceMakers Warriors legends.Watch this episode on YouTube: https://www.youtube.com/watch?v=dqbv3ekWQ14Join us as a paid subscriber on Substack at https://www.thiswarriorslife.com/Brought to you by the Warriors-mad legends at Kingz Container Crew

A jam-packed episode this week following the Warriors' momentous win over the Storm. Fonz joins for the first half to unpick the club's increasingly complicated spine situ, before Will and Brad take you through the team list and a preview for a banana skin clash with the Titans.Plus there's another PlaceMakers legend, unlikely ex-Warriors starring in Sydney, Niukore's impending departure and a beer commemorating Saturday's triumph at AAMI Park.Watch this episode on YouTube: https://www.youtube.com/watch?v=OCy8b7LH5UgJoin us as a paid subscriber on Substack at https://www.thiswarriorslife.com/Brought to you by the Warriors-mad legends at Kingz Container Crew

No Christian enjoys suffering — and the Apostle Paul knew that better than most. Called by God from the start of his ministry to endure affliction for the name of Christ, Paul wrote 2 Corinthians as a deeply pastoral letter to a church that had caused him tremendous pain. Yet rather than retreat from suffering, Paul broke into praise.In this sermon from 2 Corinthians 1:3–7, Simon Pranaitis shows how Paul's doxology reveals three God-given relationships that transform even the worst suffering into joyful hope. First, through God the Father — the Father of mercies and God of all comfort — believers receive real, active comfort in every affliction. Biblical comfort is not a weak shoulder-pat; it is God's strong encouragement, consolation, and intervention on behalf of his people. Second, through Christ, suffering and comfort both come in abundance. Union with Christ joins believers to his sufferings, but the comfort that follows is not merely equal — it overflows in proportion to the suffering endured. Third, through the church body, believers share in mutual endurance and a hope firmly grounded in Christ's death, resurrection, and return.Suffering is not an individual endurance test. It is a corporate responsibility. The saints at KCC are called to stop hiding their pain, stop avoiding others in theirs, and actively participate together — finding comfort in God, giving it to others, and embracing affliction as evidence of belonging to Christ. ★ Support this podcast ★

TWL 2026: Ep 12 - Stormy WeatherTwo losses on the trot for the Warriors and plenty to unpack as injuries hit hard and selection calls divide the fanbase - all ahead of a massive showdown with the Storm. Join us as a paid subscriber on Substack at https://www.thiswarriorslife.com/Brought to you by the Warriors-mad legends at Kingz Container Crew

TWL 2026 - Ep 11: I'm Sticking With YouFonzie is back on deck as the TWL team break down the Warriors' first loss of the season, look ahead to Sunday's showdown with the Sharks and unpack an intriguing Team List Tuesday hot off the presses + Barnett's injury and another PlaceMakers Warriors Legend profile. Join us as a paid subscriber on Substack at https://www.thiswarriorslife.com/Brought to you by the Warriors-mad legends at Kingz Container Crew

TWL 2026 - Ep 10: The Next Man Up EpisodeLike the Warriors, TWL has a couple of top-liners unavailable but will forge on regardless. Proven performer Keith Whitelock joins Will Evans, with Jimmy W making a Hanson-esque debut - and there's plenty to unpack after a sizzling 3-0 start. We review the win over the Knights, preview Friday's clash with the Tigers, discuss the increasingly complicated halves picture and the RTS/Anderson/Warbrick rumours, bring a juicy Warriors team list to you LIVE and remember another PlaceMakers Warriors legend. Join us as a paid subscriber on Substack at https://www.thiswarriorslife.com/Brought to you by the Warriors-mad legends at Kingz Container Crew

Tune in for a virtual Town Hall held on March 16, 2026: Our Common Health, Our Commonwealth: Who Decides What's Safe? hosted by Kentucky Waterways Alliance, Kentucky Resources Council, Kentucky Conservation Committee, and Sierra Club Kentucky Chapter. Connecting Legislation, Pollution, and Our Health. Environmental health, public health, and civic health are deeply intertwined. The condition of our air, water, and land shapes the wellbeing of our communities and the strength of our democracy. Who shows up, who speaks, and who votes determines whether decisions reflect the public's best interests or the priorities of corporate lobbyists. Kentucky Waterways Alliance, Kentucky Resources Council, Kentucky Conservation Committee, and Sierra Club Kentucky Chapter hosted this discussion on how environmental decisions affect public health and how current proposed legislation would prioritize polluter profits over the health and safety of every day Kentuckians — making it nearly impossible for communities to hold corporations accountable when our most basic necessities are at risk. Additionally, the League of Women Voters of Kentucky shared findings from their report How Can They Do That?, which examines how legislation can advance through the process with limited public visibility. The Town Hall starts out with testimony from Calvert City, Kentucky resident Joshua Tabor sharing his family's experience with angiosarcoma, a rare cancer linked to environmental exposures, and why these environmental protections are deeply personal for many Kentucky families. Together, we examined how decisions made in Frankfort affect Kentucky's natural resources and communities, and what Kentuckians can do to shape a healthier future. Speakers include: KWA's Michael Washburn, Joshua Tabor, KRC's Audrey Ernstberger, KWA's Nick Hart, KCC's Lane Boldman, LWA's Jeanie Lindel, and SC's Julia Finch. Watch full recording: https://vimeo.com/1174496139 Connect with the organizers: Kentucky Waterways Alliance: https://www.kwalliance.org/ Kentucky Resources Council: https://kyrc.org/ Kentucky Conservation Committee: https://kyconservation.org/ Sierra Club Kentucky Chapter: https://www.sierraclub.org/kentucky

TWL 2026: Ep 9 - Boyd-N-The-HoodThe Warriors are 2-0 and flying - joining Will, Brad and Fonz as they break down another smackdown of a contender, bring you the Round 3 team list live and preview Saturday's road trip to Newcastle. Plus club news and another PlaceMakers Warriors legend profile. Join us as a paid subscriber on Substack at https://www.thiswarriorslife.com/Brought to you by the Warriors-mad legends at Kingz Container Crew

ODH co-captain Dan Jackson joins the podcast ahead of the grand final, it's a big week for the KCC.

We're back! In this episode of The Mezzanine Floor, we're switching things up. From now on, we'll be diving deeper into the messages shared during our Sunday services and having real conversations about what they mean and how they connect to everyday life.Even if you don't attend our church, don't let that stop you from tuning in! We'll include clips from past sermon series so you can follow along and be part of the discussion.This week, Pastor Bryan, Pastor Malachi, Jaman, and Logan revisit our sermon series Make Room. Together, they explore what it truly means to create space for God in your daily life, and how to tell if you're really making enough room for Him.You can check out our content on YoutubeAs well as check out our church on Instagram and at KCC.net

TWL 2026: Ep 8 - Warbrick by BrickWill, Brad and Fonz go LIVE! for a relatively uneventful Team List Tuesday - but a very enjoyable look at the Warriors' season-opening win. Plus there's the Will Warbrick news to cover along with a preview of Friday's clash with the Raiders and another PlaceMakers Warriors legend spotlight. Join us as a paid subscriber on Substack at https://www.thiswarriorslife.com/Brought to you by the Warriors-mad legends at Kingz Container Crew

De #DCDW podcast wordt gepubliceerd om de online automotive beter te maken. In deze aflevering spreekt host Paul de Vries, oprichter van #DCDW, met Jeffrey Silva en Koen van de Laar van CARMEN Automotive BDC. Tijdens deze podcast gaan we diep in op de nieuwste ontwikkelingen waarmee CARMEN Automotive BDC de automotive branche verbetert, en waarom klantcontact in deze tijd van digitalisering en AI nog steeds cruciaal is. Paul de Vries opent de aflevering met het belang van klantcontact in een tijd waarbij digitale kanalen en automatisering steeds groter worden. Ondanks de opkomst van AI en messaging blijft telefonisch klantcontact volgens Jeffrey Silva, operationeel directeur bij CARMEN Automotive BDC, van onverminderd belang. "We lopen nu in mijn optiek nog tegen dezelfde uitdagingen als achttien jaar geleden: het goed opvolgen van klantcontactmomenten," aldus Jeffrey. Het opvolgen van DM's (Direct Mails) en andere traditionele vormen blijft een terugkerende taak, ondanks alle digitale innovaties. Koen van de Laar, mede-eigenaar van Carmen en onder andere verantwoordelijk voor de samenwerking met CARMEN Automotive BDC, benadrukt dat het opzetten van een klantcontactcentrum (KCC) of Business Development Center (BDC) meer is dan het neerzetten van een paar bureaus en een headset. "Efficiëntie en procesoptimalisatie zijn essentieel. Waar het vroeger ging om ieder contactmoment te bellen, gaat het nu vooral om relevante klanten te selecteren voor persoonlijk contact," aldus Koen. Data cleansing en automatisering worden ingezet om kostbare menskracht doelgerichter in te zetten, precies daar waar het verschil gemaakt kan worden. Tijdens het gesprek komt naar voren dat veel dealerholdings nog moeite hebben om de juiste KPI's te monitoren, zoals gemiddelde wachttijd en bereikbaarheid. "Het blijft verbazingwekkend dat veel bedrijven niet precies weten hoe lang hun klanten gemiddeld in de wacht staan," vertelt Jeffrey. Ook de rol van training wordt uitgebreid besproken; Amerika investeert bijvoorbeeld fors in de training van klantcontactmedewerkers, waarbij AI-coaching zelfs real-time ingezet wordt om medewerkers direct feedback te geven op gesprekken. AI-technologie is volgens beide gasten een grote kans voor de automotive sector, maar het vraagt om een juiste balans. Automatisering kan klantcontact optimaliseren, maar de menselijke factor blijft noodzakelijk voor complexe of emotioneel geladen klantvragen. "Het gaat erom de klant altijd de juiste keuze te bieden: wil je via een selfservice kanaal of zoek je juist contact met een medewerker? Die relevantie maakt het verschil," aldus Koen. CARMEN Automotive BDC investeert dan ook in innovatieve SaaS-oplossingen die real-time gesprekssamenvattingen genereren, medewerkers voorzien van directe kennisbank-adviezen en klantinteracties secuur monitoren. Het resultaat is een optimale ondersteuning van klantcontact teams en een verhoogde klanttevredenheid. Campagnes rondom aftersales, zoals de opvolging van APK- en bandenwissel-leads, vormen nog altijd een belangrijk onderdeel van het werk, al verschuiven deze campagnes mee met trends als de toename van all season banden. Door het combineren van techniek en persoonlijk contact wordt een hogere conversie en klanttevredenheid gerealiseerd. Data cleansing is daarin een onmisbare schakel: door geavanceerde gegevensverrijking worden alleen nog relevante klanten actief benaderd, wat zowel de kosten verlaagt als de gesprekken prettiger maakt voor klanten én medewerkers. Tot slot kijken Paul, Jeffrey en Koen vooruit naar de toekomst. Nieuwe SaaS-platformen en real-time AI coaching worden uitgerold om partners nog efficiënter te ondersteunen. De roadmap richt zich op verdere optimalisatie en het mogelijk maken van next level klantcontact, met altijd het doel: de online automotive beter maken. Wil je meer weten over hoe CARMEN Automotive BDC en partners het verschil maken in klantcontact? Luister dan deze aflevering van de #DCDW podcast, dé podcast die professionals en leiders samenbrengt om samen te werken aan een steeds betere online automotive branche!

The countdown is on! It's the middle of February, we're on the eve of another season, and the excitement is palpable! That's thanks in part to a successful hit-out at the KCC, the Hawks besting Geelong in a practice match by 17 points. We're back to recap the action, as well as discuss some big contract news, and tackle a bunch of your burning questions. It's a short and sweet Hawk Talk Podcast, and it's good to be back! Don't forget to follow us on our social channels, including on X - @HawkTalkPod Hosted on Acast. See acast.com/privacy for more information.

Subscribe to Hawks Insiders for the most in-depth and wide ranging Hawthorn coverage available. Exclusive interviews to analysis, match recaps to podcasts, the Insiders have you covered.Season 2026 is upon us and the Hawks fired up in sweltering conditions in their first pre-season hitout at the KCC.The Hawks prevailed by 17 points over the Cats — 16.15 (111) to 14.10 (94) — in front of a healthy brown and gold turnout at our new home.There was plenty to like, and plenty to refine. But for a first official outing at KCC, 16 goals and a 17-point win over the Cats is a pretty nice way to christen the place.Listen as Ash, Mick and Brad discussed: * The midfield mix and why Ward is trending towards the clear No.2 behind Jai;* What we need from our centre bounce rotations in 2026.* Reeves and Meek: how the ruck balance looked and why synergy matters more than raw hitout numbers this time of year;* Sam Butler's statement game — forward pressure, elite tackling and whether he's now locked into our best 23;* Mitch Lewis' presence up forward and how the mix of Lewis, Dear, Chol and (eventually) Gunston shapes the structure;* The kids watch — Noah Mraz competing hard and Aiden Schubert showing promise;* Why Flynn Perez is pressing hard for that SSP spot;* The upcoming Round One matchup against a GWS side dealing with significant injuries;* First impressions of the Kennedy Community Centre — strong crowd, great energy… and yes, the melted bitumen in the car park;* And much much more. We'll be back later in the week with our mid-week pod featuring all your listener questions (don't forget to get them in via our socials).Follow us on social media through the links below:Twitter | Facebook | Instagram This is a public episode. If you'd like to discuss this with other subscribers or get access to bonus episodes, visit hawksinsiders.substack.com/subscribe

The return of "What About?" Wednesdays! Text us your questions for apologist and pastor Robby Lashua!For the past three years, Northwest Christian School has helped spearhead a "pilot" program within the Colson Center for Christian Worldview:  the Colson Educators Academic Affiliation.  Every teacher has enjoyed training in Biblical worldview and nearly forty teachers, administrators, and staff have opted into a yearlong, deep-dive into Christian worldview through the Colson Fellows program.It all sounds very impressive.  But what, specifically, does it mean?Today, we are joined by Billy Hutchinson, the Director of the Colson Center's Colson Educators program, who walks us through the training, the pilot program, and what it all means for the culture and community of Northwest Christian School.For more information on the Colson Center for Christian Worldview, click here.To learn about the Colson Educators programs and opportunities, follow this link.And, to learn about Colson Fellows and potentially join a Northwest Christian-centered cohort of Colson Fellows in Training, please visit:  ColsonFellows.org/KCC."Kingdom Culture Conversations" is a podcast created by Northwest Christian School in Phoenix, Arizona.For more information on Northwest Christian School, visit: https://www.ncsaz.org/To reach out to Geoff Brown, please email gbrown@ncsaz.org or you can reach him by cell phone: (623)225-5573.

A Dover man involved in a hit-and-run while driving without a licence has avoided being sent to prison .24 year-old Tyler Keyes from St Radiguns Road was driving his girlfriend's BMW when he collided with a moped at the Whitfield roundabout last June, leaving the rider unconscious.Also in today's podcast, a meeting is taking place at County Hall to discuss KCC's budget for the next financial year.It's Reform UK's first in charge of the authority and leader Linden Kemkaran has previously said the council is focused on delivering savings for residents. Hear from our local democracy reporter Simon Finlay.There's going to be a public meeting later over the regular closure of a busy road in Medway.The Lower Rainham Road, which runs from Gads Hill to Otterham Quay Lane, was shut for 100 days last year. We've been speaking to Gillingham and Rainham MP Naushabah Khan who has organised the event.Employers across Kent are being encouraged to consider taking on an apprentice.The EKC Group is looking for 100 pledges from businesses to consider it in the next 100 days.And, Leigh-Anne has been on our sister radio station kmfm talking about her debut album.The former Little Mix star caught up with Jack on the Hit List ahead of the release of 'My Ego Told Me To' next week. Hosted by Simplecast, an AdsWizz company. See pcm.adswizz.com for information about our collection and use of personal data for advertising.

A bartender wrongly accused of stealing is to receive thousands in compensation after an employment tribunal ruled she was unfairly dismissed following a wage dispute.The 22-year-old is being awarded more than £4,000 after a judge found those running the Thomas Becket pub in Canterbury withheld her pay packet.Also in today's podcast, the leader of Kent County Council has written to the Home Office to ask for more funding for young asylum-seeking adults who have left care.KCC currently receives no government support for people the authority continues to look after for four years once they have reached the age of 21.The owners of the UK's most famous scenic railway have been challenged to justify their decision to close the ride before a panel of councillors.Dreamland announced last Tuesday that it was closing the century-old ride at the amusement park in Margate – you can hear from the Mayor of the town who wants them to appear before a scrutiny panel. Villagers have raised concerns about plans for a new housing estate saying they're coming “under attack”. It's after plans were put forward for the properties at Mountain Farm in Hamstreet. And in football, you can hear from Gillingham boss Gareth Ainsworth who is ready to make changes when they return to action this evening.The Gills visit Notts County on the back of a 4-1 humbling by leaders Bromley at Priestfield on Saturday. Hosted by Simplecast, an AdsWizz company. See pcm.adswizz.com for information about our collection and use of personal data for advertising.

On this week's Access Hour, we bring you highlights from the first hour of the 2026 Kentucky Conservation Committee's Legislative Summit that was held online on Sunday afternoon, January 25th. You can learn more about it and find links to all the great materials referenced at https://kyconservation.org/legislative-summit-2026 The Summit includes a review of conservation legislation and trainings on key conservation and environmental issues in Kentucky to provide you with all the necessary advocacy tools you need during the 2026 Kentucky General Assembly and beyond. These sessions included a broad look at the anticipated topics of the 2026 General Assembly, related federal legislative issues, basic training on ways for citizens to engage as a “citizen lobbyist”, plus tips on how to be more effective with your legislative advocacy in a virtual world or in person. On today's show, you'll get an overview of bills that are already filed in the General Assembly, or anticipated to be filed, along with KCC's analysis and recommendations for action, and a preview of the State Budget. Want the latest information on environmental issues impacting Kentucky? Want to be a more effective citizen advocate during the General Assembly? Want to know how the recent elections will impact state and federal policy on environmental issues? Tune in for the resources you will need to be an effective advocate for a wide range of environmental issues impacting Kentucky. After a brief welcome from KCC Director, Lane Boldman, KCC's Legislative Agent, Randy Strobo, provides highlights of House and Senate bills reviewed by KCC to date. And finally, Pam Thomas from the Kentucky Center for Economic Policy will provide a State Budget Overview. Resource: KCC Citizens Guide to the General Assembly 2026: https://drive.google.com/file/d/1R5bSKYXp6mEF1wM34kKha8pGdWCRJuqM/view?usp=sharing Resource: List of Lawmakers and Issues 2026: https://docs.google.com/spreadsheets/d/1JRMQ-qxz4hjXOvWeN_MjcGAIOX8fYqqW-JYTaCGaz04/edit?usp=sharing Resource: How a Bill Becomes a Law in Kentucky: https://drive.google.com/file/d/1a0ZJSKw3os9UQivaW9VpS-S-bXWZ60tB/view?usp=sharing Presentation Slides: Bill Highlights to Date: https://drive.google.com/file/d/1E806k-oxQ4h9aSP6lgha5KKq1LaXnhTN/view?usp=sharing Presentation Slides: Ky Policy Budget Preview: https://drive.google.com/file/d/1N2g04vAJkvTiv1DoKAn2Cw0yKNRUFx-s/view?usp=sharing KyPolicy Budget Preview: https://kypolicy.org/preview-of-the-2026-2028-kentucky-state-budget/ Governor's Budget Proposal: https://kypolicy.org/2026-governor-andy-beshear-budget-proposal/ The Access Hour airs on Forward Radio, 106.5fm, WFMP-LP Louisville, every Wednesday at 2pm and repeats Thursdays at 11am and Fridays at 1pm. Find us at https://forwardradio.org If you've got something you'd like to share on community radio through the Access Hour, whether it's a recording you made or a show you'd like to do on a particular topic, community, artistic creation, or program that is under-represented in Louisville's media landscape, just go to https://forwardradio.org, click on Participate and pitch us your idea. The Access Hour is your opportunity to take over the air waves to share your passion.

This week on KCC, we're covering two heartbreaking and unrelated cases with one haunting similarity: both involve mothers who disappeared and were never seen again. We'll be taking a closer look at the stories of Ada Jane Groomes and Jamie Peterson, and the mysteries that surround their disappearances.

A major incident has been declared as disruption to water supplies has forced some Kent schools to close.Homes and businesses in areas including Tunbridge Wells, Maidstone and Canterbury have been affected. Hear from a Pembury resident who didn't have water over the weekend.Also in today's podcast, bosses in Medway could be pushed into using exceptional financial support from the government after their funding increase wasn't as big as expected.Under the new Fair Funding Settlement, the council anticipated a significant increase, but the provisional one still leaves a shortfall of almost £8 million.A mum from Tunbridge Wells whose son has Spinal Muscular Atrophy is backing calls from Jesy Nelson for earlier screening.The Little Mix star's seven-month old twin girls have been diagnosed with the condition - which affects breathing, swallowing and muscle control.A Kent MP says plans to change the criminal justice system are essential for victims, defendants and the people who work in it.Most recent stats show a backlog of around 80,000 crown court cases in England. We've been speaking to Chatham and Aylesford's Tris Osborne.A former Kent soldier has spoken to the podcast for the first time since completing a challenge to climb the seven highest peaks on all seven continents.Hari Budha Magar lost his legs while serving in Afghanistan and uses specially adapted prosthetics.And in sport, Chatham Town are through to the fifth round of the FA Trophy.It's the first time they've reached this stage of the competition and follows a 1-0 victory over National League side Carlisle United. Hosted by Simplecast, an AdsWizz company. See pcm.adswizz.com for information about our collection and use of personal data for advertising.

Huge waves smashed into cars as Storm Goretti brought wild weather to the Kent coast overnight.People living along Sandgate Esplanade, near Folkestone, woke up to see vehicles strewn across the road - which was flooded and covered in shingle – we've spoken to a witness and bosses in charge of the clean-up. Also in today's podcast, there's been plenty of reaction from the news Kent County Council is proposing increasing council tax by 3.99% in its draft budget.The authority is recommending a hike of a full 1% below the cap set by the government but there are concerns it could lead to cuts to local services. Major plans to redevelop a town centre street into a car-free zone with al fresco dining are finally moving ahead.The creation of a “cafe culture” in Earl Street, Maidstone, from Week Street down to its junction with Pudding Lane, is a long-held ambition of the local authority.A campaign's underway to recycle hundreds of Christmas trees in Kent - while raising money for charity.Heart of Kent Hospice in Aylesford picked up almost 700 trees last year and this year they're hoping to make it 1000. And England rugby player Rosie Galligan will be hoping to inspire the next generation when she returns to Kent this weekend. The 27-year-old, who's from West Malling, will be taking coaching sessions at Aylesford Rugby Club's recruitment drive  Hosted by Simplecast, an AdsWizz company. See pcm.adswizz.com for information about our collection and use of personal data for advertising.

251223(2) [찬란한 경제] (1) 'V11·100만 달러·94.8%' 세계 최고가 된 여제 안세영 / (2) 송성문 영입한 MLB 샌디에이고...박찬호·김하성 등 거쳐 간 팀 / (3) ‘인종차별 피해' 김우성 심판도 3개월 배정정지 징계, 왜? / (4) ‘트리플더블+5연승' KCC 상승세 이끄는 허훈 - 윤승재

Subscribe to Hawks Insiders for the most in-depth and wide ranging Hawthorn cover there is. From exclusive interviews to analysis, match recaps to podcasts, the Insiders have you covered.A bit of fun for you as we look to wrap up 2025, and an easy-listening (at times) 10-minute episode taken at our break-up dinner and drinks at the Corner Hotel.What was billed as a mere ‘questions without notice' segment drew out some pretty important information from you all including:* How many steps each day does Sam Mitchell take?;* Who is the biggest book-reader in the HI crew?;* Which Insider snubbed the opportunity to watch the greatest game in Hawthorn history from Round 12, 1999;* Which HI self-congratulator of the year welcomed themselves to the pod?;* Which father-son selection has Angry Brad already retired;* FINALLY - Who are the four people named on Hawthorn's Mount Rushmore - forever now on the record?We hope you enjoy - we will be dropping some fun articles over the next few weeks to and be back online for regular bods towards the end of January - after the AO has finished.The Hawks Insiders 2026 Season Launch will be held at the Kennedy Community Centre, in the rooms above the AFLW Pavilion, on Wednesday, March 4.It's the ultimate two-for-one deal. The chance to get among the action at our pre-season panel, and get a close-up look at the KCC for yourself.Full details to come in the new year, but space will be extremely limited. So get out your 2026 calendars and put a big circle around March 4 now.Follow us on social media through the links below:Twitter | Facebook | Instagram This is a public episode. If you'd like to discuss this with other subscribers or get access to bonus episodes, visit hawksinsiders.substack.com/subscribe

A second Kent hospital is making patients and staff wear face masks amid rising flu cases, which have not yet hit their peak.It comes as we've spoken to a pharmacist who says there is plenty of vaccine available despite reports of low stock. Also in today's podcast, a controversial contraflow system has been set up on the M20 in anticipation of high passenger numbers heading through Kent to Europe.Bosses say the system will act as a pressure valve to minimise the impact of congestion further down the road – but just this morning a broken down lorry within the contraflow caused a backlog stretching back miles. Government education chiefs have confirmed funding for new special education needs schools in Kent, calming fears certain projects could be scrapped amid ongoing delays.KCC say it's been told funding will be provided by the government for the new schools in Whitstable, Swanley and Northfleet. A fundraising campaign has been launched to help a man from Deal with Locked In syndrome speak again. Jeff Brown suffers from the extremely rare condition, which leaves the person conscious but unable to speak or move, after a stroke in 2019 – you can hear from his family who say there's massive potential for improvement. And a Thanet youth club is closer to securing its long-term future after being told it'll receive a huge grant.Pie Factory Music has been campaigning to buy its building in Ramsgate after the county council announced plans to sell it – you can hear from their very relieved CEO.  Hosted by Simplecast, an AdsWizz company. See pcm.adswizz.com for information about our collection and use of personal data for advertising.

Subscribe to Hawks Insiders for the most in-depth and wide ranging Hawthorn cover there is. From exclusive interviews to analysis, match recaps to podcasts, the Insiders have you covered.What a difference a year makes. When the Hawks Insiders team last visited the Kennedy Community Centre in November 2024, there wasn't a single blade of grass on the AFLW and Community Oval.This time around — when Ash, Danny and Daz were given a grand tour by lifelong Hawks nuffies, CEO Ash Klein and COO Jacob Attwood — we couldn't quite believe our eyes. The grass was down. The ovals were defined. The buildings were a hive of activity. Players were training the house down, staff were embedded, and the Kennedy Community Centre had gone from a major construction project (and HI regular Paddy Malone's dream) to a fully functioning football home.

Le 3 décembre, des travailleurs de la société minière KCC ont marché dans les rues de Kolwezi, dans la province du Lualaba, dans le sud de la RD Congo. Ils réclamaient des mesures de sécurité pour faire face aux mineurs artisanaux, qu'ils accusent de les agresser sur les sites miniers. En toile de fond : le manque d'espace pour ces mineurs artisanaux qui est la source de leur mécontentement.

Subscribe to Hawks Insiders for the most in-depth and wide ranging Hawthorn cover there is. From exclusive interviews to analysis, match recaps to podcasts, the Insiders have you covered.The HI crew reassembled to unpack an eventful few weeks in Hawthorn land — from AFLW and trade updates through to preseason risers, jumper number chatter, and all the latest whispers out of the KCC.Hosted by Ashley Browne, the pod featured Julia, Mick, Brad, Nat and Daz, plus special guest Marnie Cohen from Kanga TV to discuss everything you wanted to know (and more) about former North defender Flynn Perez, who is currently training with the Hawks.

Subscribe to Hawks Insiders for the most in-depth and wide ranging Hawthorn cover there is. From exclusive interviews to analysis, match recaps to podcasts, the Insiders have you covered.The draft has been run and done, and the KCC is the proud home for five new fledgling Hawks. Ash Browne, Mick Cowan and Danny Prins look back at the draft before looking forward to preseason next Monday.

Baltimore-bred Life On Planets flexes his funky flavors and eclectic inspirations with a jackin' guest mix for Dirtybird Radio to mark his new release with Black V Neck titled "Drip Drop (Handle That)" VR warm-up set:QRTR - "Alegria" [Broken Levee]Kevin Knapp - "Special Delivery" [SNOE]Brunello - "Melted" [Mellow Circus Records]Bonafide feat. Nadav Isaac - "Ego Trip" [Get Physical Music]Life On Planets guest set:Elastic Joey Purp Daddy (feat. Sexyy Red) TokischaFast Money Drewbyrd, Daboii & 22nd JimWork Come First (Sev's Mix) *Unreleased- drops Sep 26 MASON Collective - Room For Me [Nervous Records] In The State of New York TiptoesI'm Dirty!!! (Original Mix) Mr. GGinanatonica Darren KlementiHarry Romero - Tania (Riva Starr Remix)The Human Body PrinceHeaven (G Flame's UK House Revamp) G Flame, KCC, Emile ChambersAnother One Dj minx Harry Romero - Hot MusicDrip Drop (Handle That) - Black V Neck X Life On PlanetsFREAK ! extended NEZME SO HORNYSmoke Show Mz Worthy Clayton Williams L.O.P.life

For our August Monthly Mood, Chelsea is back with another important summer safety topic—this time focusing on low-head dams: what they are, why they exist, and the hidden dangers they create in the water. Join the KCC team as they discuss these important water structures.

Welcome back to the East Kentucky Works podcast! In this episode, we're tackling some common misconceptions about the Kentucky Career Centers. Many people still think of them as the old "unemployment office," but they've evolved into something much more. We're here to bust three major myths and show you how the KCCs are a powerful resource for everyone in Eastern Kentucky, no matter where you are in your career journey.Myth #1: Kentucky Career Centers are just a depressing place to get a check.Myth #2: If I have a job, even if I'm unhappy or underemployed, the KCC can't help me.Myth #3: There are no good jobs in Eastern Kentucky; all the opportunities are elsewhere.Don't let outdated ideas hold you back! The Kentucky Career Centers are modern, dynamic hubs of opportunity for everyone in Eastern Kentucky. We encourage you to visit a KCC near you and see for yourself how we can help you build the career and life you want, right here at home.Visit our website at ekcep.org to find your nearest Kentucky Career Center, and follow us on facebook for updates and success stories!

Join us for an eye-opening episode as we debunk common misconceptions about employment, second chances, and the invaluable resources available at Kentucky Career Centers (KCCs) and EKCEP. We tackle harmful myths head-on, sharing inspiring stories and revealing the truth about who KCCs serve, the diverse career paths they support, and how they empower individuals to achieve their full potential.In This Episode, We Discuss:Myth #1: People with Substance Use Disorder (SUD) or who are justice-involved will never change and can't find meaningful employment.The Taulbees' Inspiring Journey: Hear firsthand how the Taulbees overcame significant challenges related to SUD and justice involvement, rebuilding their lives with the crucial support of KCC and EKCEP's Recovery & Reentry program. We'll explore the specific ways they received help, from skills training and job coaching to connections with "fair chance" employers.Systemic Support for Second Chances: Discover how KCCs offer specialized programs, including peer support, recovery resources, expungement assistance, and guidance on discussing past challenges with employers. It's about tapping into immense resilience and overlooked talent.The Power of Fair Chance Employers: Learn why businesses are increasingly recognizing the value of hiring individuals in recovery or with past records, often finding them to be loyal, motivated, and dedicated employees.Myth #2: Kentucky Career Centers only help people find blue-collar or factory jobs.A World of Diverse Career Opportunities: Prepare to be surprised by the wide array of industries KCCs work with! We'll highlight opportunities in healthcare, IT, professional services, education, advanced manufacturing, remote work, skilled trades, and more.Personalized Career Paths, Not Just Jobs: Understand how KCCs focus on YOUR individual skills, interests, and career goals, offering tailored advice and guidance for a truly personalized job search.Training for Tomorrow's Workforce: Find out about WIOA-funded training programs that lead to credentials in high-growth, diverse fields, moving far beyond traditional manufacturing roles.Support for All Job Seekers: Whether you're a seasoned professional looking to change careers, upskill, or find a higher-level position, KCCs offer valuable services like resume workshops, interview coaching, and networking opportunities.Myth #3: You have to meet strict low-income requirements to qualify for KCC services.Universal Access is Key: We clarify that many core services at Kentucky Career Centers are available to anyone seeking employment assistance, regardless of income. This includes access to job listings, computer labs, resume software, basic career advice, and workshops.Understanding Program Eligibility: While some intensive services and training (often WIOA-funded) do have eligibility criteria, these can include being a dislocated worker, a veteran, a youth facing barriers, or someone with a disability – it's not solely about income.Don't Self-Disqualify! The most important takeaway: Don't assume you won't qualify. We strongly encourage you to visit or call your local KCC to discuss your unique situation. Their staff are there to help you navigate available resources.Services for Employers Too! Remember that KCCs and EKCEP also provide a wide range of services to businesses of all sizes, completely free of charge.Relevant Links & Resources:Find your local Kentucky Career Center: ekcep.org/find-a-careerLearn more about EKCEP's Recovery & Reentry Program: https://ekcep.org/recovery-reentryAre you ready to explore new career possibilities or find the support you need to ac