Podcasts about pedaling

Dr. Deb Muth 00:00:09 Hi there, how are you? Bob Miller 00:00:10 Excellent! Pedaling as fast as humanly possible, but doing okay. Dr. Deb Muth 00:00:14 Good, good. Well, I’m looking forward to our conversation today. This should be amazing. Bob Miller 00:00:20 Yeah, it should be a lot of fun. Dr. Deb Muth 00:00:22 Yeah, anything that’s off-limits for you in, our conversation? Bob Miller 00:00:28 No. Dr. Deb Muth 00:00:29 Okay, anything you want me to make sure we cover for you? Bob Miller 00:00:33 Well, I mean, is it okay if we put a little plug-in for our software? Dr. Deb Muth 00:00:35 Absolutely. Bob Miller 00:00:36 Yeah. Dr. Deb Muth 00:00:37 Absolutely. Bob Miller 00:00:36 Yeah. Dr. Deb Muth 00:00:37 Absolutely. Bob Miller 00:00:38 Hey, can we… can we do a screen share? Yes, we can. Yeah, because I want to show you some maps, and… Dr. Deb Muth 00:00:43 Okay. Things like that, yeah, so… Perfect. So just let me know when you want to do screen share. Bob Miller 00:00:48 Okay. Dr. Deb Muth 00:00:49 And yeah, feel free to plug your software wherever you want to. Bob Miller 00:00:53 Okay, well, good. Let me pull up a, a slide for that, and give me one second, I just want to shut the door to my office to get the noise down. Dr. Deb Muth 00:01:01 No worries. Bob Miller 00:01:16 And, how should I refer to you? Dr. Debb? Dr. Muth, what do you like? Dr. Deb Muth 00:01:18 Dr. Deb is great, or Deb, either way, I’m pretty informal, so… Bob Miller 00:01:22 Yeah, and… Bob is fine for me. Okay. Yeah. Yeah, there you go. Why people feel like they need this, son. Special name, it’s like, seriously. Dr. Deb Muth 00:01:33 Right? I agree. Bob Miller 00:01:35 When I work with my clients, it’s like, Dr. Millison, just, just bop, just, just bop. Dr. Deb Muth 00:01:41 Yep, that’s how I am, too. Just call me Deb, it’s good. Dr. Deb Muth 00:01:44 They feel a little awkward with that, you know? They’re not used to that, but… Bob Miller 00:01:48 Alright. And you’re a naturopath, medical doctor. Dr. Deb Muth 00:01:52 A nastropathic doctor and a nurse practitioner. Oh, nice. Yeah, so I got the best of both worlds, right? Bob Miller 00:01:58 Yeah, damn. Okay. Alright, so here we go… There we go. Alright, so I got that ready, and then I will do a, I will do a screen share. I think you’re gonna really, appreciate what we’ve come up with. We’ve come up with the concept of, Cellular CPR. Dr. Deb Muth 00:02:23 Oh, nice! Bob Miller 00:02:24 And that is, construct the cell membrane, Protect the cell membrane. And restore it if it’s damaged. Dr. Deb Muth 00:02:32 Love that. Bob Miller 00:02:34 I love that. Yeah, so that’s what we’re focusing on, and then how, You know, we want to get to the point that, you know, most people think of genetics, they think of, like, 23andMe or Ancestry. Dr. Deb Muth 00:02:44 Yeah. Bob Miller 00:02:45 And then you have the professional geneticists who are looking at, you know, odd things that could create a disease. We’re looking at functional genomics. Dr. Deb Muth 00:02:54 Which is so much better. Bob Miller 00:02:56 Yeah. Are you familiar with what we do here, or… Dr. Deb Muth 00:02:58 A little bit, a little bit. So, it’ll be new to me, too, so I’m excited. Bob Miller 00:03:03 And how much time do we have? Dr. Deb Muth 00:03:04 We have an hour, give or take a little bit on either side. Do you have a hard stop anywhere? Bob Miller 00:03:10 No, no, I put a, I moved my clients around, and I don’t have anybody till, 3.30, so we’re good. Okay. Dr. Deb Muth 00:03:16 Perfect. Alright. Bob Miller 00:03:18 It’s like we’re getting started early as well, so… Dr. Deb Muth 00:03:19 Yeah, we’re getting started a little bit early, so that’s good. Bob Miller 00:03:22 Yeah, I just got my office cleaned up, so… Dr. Deb Muth 00:03:23 Okay, good. All right, are you all set to get started? Bob Miller 00:03:28 I’m good to go, my friend. Dr. Deb Muth 00:03:29 I’m gonna just record a little intro and a little bit of a, hook for people, and then we’ll get started. I’ll ask you to kind of tell us a little bit about yourself, and then we’ll just take this conversation wherever it’s supposed to go. Bob Miller 00:03:39 Okay, you got it. Dr. Deb Muth 00:03:40 Alright, sounds good. So what if the reason you’re not healing isn’t your diet, your supplements, or your labs, but it’s actually your genes? Dr. Bob Miller is uncovering how genetic variants, when combined with modern toxins, explain why some of us stay sick no matter what we try. Today, we’re talking genetic pathways, detox blocks, and the new science every wellness warrior needs to know. Welcome back to Let’s Talk Wellness Now, the show where we uncover the root causes of chronic illness, exploring cutting-edge regenerative medicine, and empower you to heal from the inside out. I’m Dr. Deb, your medical detective, and today, our guest, Dr. Bob Miller, is a true pioneer in functional genomics. He’s a board-certified traditional naturopath and the founder of Neutrogenetic Research Institute. And he’s the leading groundbreaking research on how genetic variants influence chronic illness, inflammation, and detoxification. His work has been recognized on international stages, uncovering links between genetic expression and conditions like Lyme disease, mast cell activation, or MCAS, and mitochondrial dysfunction. I’m so excited to talk to Dr. Bob today. He is gonna reveal some things that even I don’t know about, so I’m excited to learn alongside of you guys. So… Dr. Bob, let’s get started. Tell us a little bit about yourself, and kind of how you got on this journey. Bob Miller 00:05:04 Well, that’s, that’s interesting. I was sort of like a mid-career coming to the natural health field, because in my early 30s, I found myself with a severe case of ulcerative colitis. Bob Miller 00:05:15 And I was in the hospital for 21 days. probably within hours of death, pleading to death. And they told me I’ve got one option, and that is cut out the colon and wear a bag. Didn’t sound like a lot of fun. Dr. Deb Muth 00:05:27 Not an option I would want. Bob Miller 00:05:29 So, you know, the medical folks wasn’t real happy with me, but I said, yeah, I’d like to explore some alternative things.Never thinking that I’d get into this field, and then I just, you know, worked with some herbalists and things that I found absolutely fascinating. So, that’s how I got into this around 30 years ago. And, haven’t looked back since, and just having a… having a blast as we now move into how our genetics impacts things. So, that’s what we’re gonna… that’s what we’re gonna talk about today. Dr. Deb Muth 00:05:58 I’m excited to talk about this genetic thing. When you started over 30 years ago, what kind of patience and problems first inspired you to dig deeper into that root cause healing and kind of get into the genetic piece of it? Bob Miller 00:06:10 Sure. Well, you know, as a… now, I’m in a part of the country called Lancaster County, Pennsylvania, where there’s a lot of Amish and Mennonite, and they gravitate towards these things.So, this is their first thing to do, and that doesn’t work, then they’ll go other routes. So, you know, back then, we just saw typical, you know, a little tired, constipation. You know, a little bit of fatigue, arthritis, those kind of things. But things have changed dramatically over the years, as people are now getting more chronically sick. You know, it’s worse than it’s ever been. And what we’re finding is the, the culprits Primarily is mold exposure and Lyme disease. When people get those two together, they’re just… it’s an inflammatory cascade that nobody can seem to unravel. So that’s where we spend a lot of our time. And we’re also spending a lot of time looking at mental health, like ADD, ADHD. And, we give… this year I’ll be speaking at three autism conferences. And we can dig into that a little bit as to why we think we’re seeing such a dramatic increase. And aside from autism, that used to be 1 out of 1,000, now it’s 1 out of 33, or 23. You know, we’re also seeing dramatic increases in ADD, ADHD. People are stressed out. And today, I think we’ll have the time to actually go through and show how environmental factors combine with genetics to cause that to happen. So we’ll… we should have a fun visit here today. And today, I think we’ll have the time to actually go through and show how environmental factors combine with genetics to cause that to happen. So we’ll… we should have a fun visit here today. Dr. Deb Muth 00:07:37 This should be a fun visit. We can cover lots of topics. I am so excited. So, you founded Nutri Genetic Research Institute in 2015. What did you hope to accomplish, and what kind of surprised you in your findings so far about that? Bob Miller 00:07:51 Well, you know, let’s back up at what, you know, genetics is used for. Everybody’s familiar with 23andMe and Ancestry that, you know, tells you where your ancestors came from. Then you have your professional geneticists. I mean, these are people with a degree in genetics. And they’ll look for, you know, very odd sort of things that are prone to relate to a disease. So there are disease-related genetics. Well, in functional, we don’t look at either of those. We look at For example, how you’re breaking down your fats and utilizing them. How you’re recycling your glutathione. How you might be handling your iron. And none of those are disease-causing on their own.And none of those are disease-causing on their own. But when they pile up on you, and then combine that with environmental factors, that’s when things start to go south on us. So, that’s what we’re doing, we’re looking at patterns. And our first foray into this was, we did studies on Lyme disease. And our first foray into this was, we did studies on Lyme disease. So, we looked at, like, I think 50 people with Lyme disease. We looked at their genome. So, we looked at, like, I think 50 people with Lyme disease. We looked at their genome. And we found patterns that were more evident in those with Lyme. Now, this doesn’t… these genetics don’t mean you get Lyme, it just means if you get Lyme, you react worse to it. And we found patterns that were more evident in those with Lyme. Now, this doesn’t… these genetics don’t mean you get Lyme, it just means if you get Lyme, you react worse to it. So, as you know, some people get Lyme, they go on a round of antibiotics, and they’re done. So, as you know, some people get Lyme, they go on a round of antibiotics, and they’re done. Others have a little more struggle, and then others are struggling terribly for years. So there’s an old adage of genetics loads the gun, environment pulls the trigger. Dr. Deb Muth 00:09:14 Yeah, that is so true, and I think when we’re talking about Lyme and mold and things like that, we forget sometimes that our genetics can predispose us to be more sensitive to those things, and if we have genetic pathways where we don’t clear things properly, it’s harder for us to get them out of the body. And then you add on that whole rain barrel effect that we’ve always used as a functional medicine term, right? If the barrel’s half full, you’re okay. If it’s full, and now it’s spilling over, it’s a bigger problem. Have you guys found, too, that some of these environmental things actually are changing the genetics of people, or how they’re processing their own genetics? Bob Miller 00:09:53 Well, let’s go back to, Genetics 101. But we’ll go back a little bit further. So, what an interesting mechanism, what a miracle the body is. Bob Miller 00:10:03 Fats, carbohydrates, proteins, drink water, breathe air, expose the sunlight, and somehow everything gets made. I mean, when you just step back and think about that, it’s like, It’s pretty darn amazing. Dr. Deb Muth 00:10:15 I always tell women, you know, the fact that we get pregnant and we have healthy pregnancies and births is a miracle, because if we had to try to control that, that wouldn’t work so well. Bob Miller 00:10:25 Right. Well, that’s another miracle. These microscopic sperm and egg, human being, 9 months later, it’s like. But even inside of us. We are making our hair, our skin, our nails, our blood vessels, our ATP, our energy, it’s all being created. Well, that gets created by enzymes. So, enzymes take one substance, combine it with something else, and make something new. Then another enzyme comes along and does the same thing. Your DNA is the instructions on how to make the enzymes. So, when we are conceived. If it’s a, if it’s a female, of course, it’s the XX, the two chromosomes. You know, we’ve… everybody’s seen those… the genetics that… Listed pair. So, if it’s a female, the father donated the X enzyme. And the mother has no choice but to give the eggs, so that’s female. If the father donates the Y, you have a male that’s in chromosome number 1. Then 2 through 23 is the rest of the instructions on how to make enzymes. So, what can happen? We can get what are called SNPs, single nucleotide polymorphisms. And SNPs just mean that the instructions to make the enzyme’s not quite as good. So, if one parent gives a SNP on the making of an enzyme, The enzyme’s fine. It works. But, general rule of thumb, It may only work at 70-80% of efficiency. Now, a good analogy is think of an 8-cylinder and a 6-cylinder car. If parents give you good information, that’s like having an 8-cylinder car. If one parent gives you that snip, it’s like having a 6-cylinder car. Now, is a 6-cylinder car a fine car? Sure. It’ll get you from point A to point B, but it’s just going to have the power of an 8-cylinder. Then if both parents give you a SNP on the same enzyme, it may be 30-40%, and that’s like having a 4-cylinder car. Sits in the driveway, looks the same, puts gas in it, everything. But if you’ve got a 4-cylinder car. Probably not a good idea to go cross-country pulling a trailer behind you up and down mountains. Dr. Deb Muth 00:12:29 This is true. Bob Miller 00:12:32 So… We can get an 8-cylinder, 6-cylinder, or 4-cylinder enzyme. Now, if it’s not under a lot of stress, if that 4-cylinder car is just taking you to the bank and the grocery store. It’s just as good as an 8-cylinder car. But if you gotta pull that trailer, and there’s a lot of stress on it, being mountains, it’s gonna struggle. Now, there’s one other little caveat to this, and that is some genetic mutations are gain-of-function. They actually work faster. Now, we have enzymes that do all kinds of things. We have enzymes that make and recycle our antioxidants, but we also have enzymes that make inflammation. No, that’s a good thing, because if we get a virus or bacteria, if you didn’t make inflammation to kill it, well, we’d all die of infection. So, you know, we tend to think of free radicals as bad, antioxidants as good. They both play an important role. But interestingly, some of the major enzymes that make inflammation, they can be overactive. They can be turbocharged. And when they’re stimulated by environmental toxins, they overreact. Bob Miller 00:13:40 And therein lies the problem. When they overreact, we have a problem. Bob Miller 00:13:46 So, if we have genes that overreact when stimulated. And then the enzymes that take care of inflammation are underactive. Then you’re gonna be more inflamed. You know, the majority of people that, you know, come for functional medicine Or naturopathic help, or… Inflammation that they can’t seem to get under control. Dr. Deb Muth 00:14:06 Right. Bob Miller 00:14:07 And we will be, you know, during this hour, we’re going to look at some of the pathways that make that happen. So, what we can do then, we can’t change our genetics. When you’re conceived, that’s the hand you’re dealt. When your life would be over, if someone would take some tissue and measure, it’d be exactly the same as conception. Does it change. Bob Miller 00:14:28 The enzyme’s ability to do its job may be compromised. Because remember I said there’s a, the enzyme takes a cofactor. So an enzyme takes substance A, cofactor, make substance B. Well, if that cofactor’s not there, the enzyme’s not going to work either. So, you could have an 8-cylinder car, and if there’s no gas in it, it’s not going anywhere. So… It’s the strength of the enzyme, it’s the cofactor to do the A to B conversion. And that’s what we’re going to get into. So, many people say, well, where did these SNPs come from? Nobody knows for sure. Sometimes they’re what’s just called de novo, when the sperm and egg go together, the instructions get mixed up a little bit. We do believe a lot of it came from a long time ago, when we were almost wiped out by sexually transmitted diseases. And those STDs were altering the genes when the conception, in other words, when the sperm went into the egg, the STDs were interfering. And causing the problem, so… I often joke, if you want to blame somebody. Blame your great-great-great-great-great-great-great-grandparents for, being a bit promiscuous, so… Dr. Deb Muth 00:15:31 Yeah, for being… having a little too much fun, right? Bob Miller 00:15:35 So, we don’t know for sure, but, you know, there are some that, But most of the SNPs that we get inherit from our parents. So, if you look at a child. And you look at the SNPs. 99.9% of the time, it came from one of the parents. Dr. Deb Muth 00:15:50 In identical twins, do they have the exact same identical makeup? Bob Miller 00:15:54 Yep, Dr. Deb Muth 00:15:56 But not in fraternal twins, correct? Bob Miller 00:15:59 No, no, those could be different, Jeff. Dr. Deb Muth 00:16:00 It could be different because they have different sacs, they’re not sharing that same genetic makeup. Bob Miller 00:16:04 Yeah, so keep in mind, both your mother and your father have, you know, the two And so you get one from one parent, one from another. Dr. Deb Muth 00:16:13 So… Bob Miller 00:16:14 Interesting situation. I had, 3, 3 boys. And, we were looking at an enzyme related to breaking down oxalates. Now, the mother and father each had one SNP, and that’s called heterozygous. Three boys, and they all come together, they’re Amish boys, they’re a lot of fun. And I looked at their genomes, and the one boy didn’t have any SNPs at all. And one had won. And the other one had two. Dr. Deb Muth 00:16:41 Interesting. Bob Miller 00:16:42 So, we don’t quite know how these things get handed off, but with the parents each having one, you could have a child with none, one, or two. So, the one, his ability to break down oxalates, which is fine. The other one was slightly impaired, and the other one was dramatically impaired. So, you can have 3 children, and it all depends what the parents have. Now, if a parent has a homozygous, or 2 copies. And the other parent has nothing. Every child will have one. Okay. If both parents are homozygous, that they both have two, Every child will have two. Dr. Deb Muth 00:17:19 too. Bob Miller 00:17:20 Yes, so that’s the way it works, but, you know, but it’s somewhat rare that both parents are homozygous on an enzyme, but it can happen. Dr. Deb Muth 00:17:27 Do we think that infections today, like Lyme disease or mold exposure, things like that, if the parent, the woman, primarily, I’m thinking, is pregnant, and she actively has these infections. Can those infections affect the genetics, kind of like a past sexual transmission did where we thought back in the day? Bob Miller 00:17:47 Yeah, I… I mean, I’m not that much of a geneticist to answer that for sure, but my thought would be no, that at conception, the pattern’s made. Dr. Deb Muth 00:17:55 Okay. And then that’s… that’s the hand you’re dealt. Bob Miller 00:17:58 Yeah. So, I tell people we have good news and bad news. The good news is we can compensate for the weakness. The bad news is we can compensate for the weakness. Dr. Deb Muth 00:18:09 That is so very true. Bob Miller 00:18:11 Yeah, we can’t, because I often get asked, so we’ll do some things now, and we’ll check my genes again, and they’ll be better. It’s like, nope. Dr. Deb Muth 00:18:18 Oh, – – Bob Miller 00:18:19 You gotta play the hands you’re dealt, so… Dr. Deb Muth 00:18:21 That’s right. Bob Miller 00:18:22 You can test your genetics… if you’re looking at the same enzyme, you can test it every year. It’s not gonna change. It’s like the blueprint. Dr. Deb Muth 00:18:30 It’s good and bad, right? It’s the one test you only have to do once in your lifetime. Bob Miller 00:18:34 No, unless, you know, like, our. Dr. Deb Muth 00:18:36 All the time. Bob Miller 00:18:37 Yeah, now our test looks at, called the Functional Genomic Analysis Test of your genomic Resource. We look at 220,000 steps. Dr. Deb Muth 00:18:46 Wow, that’s a lot. Bob Miller 00:18:47 That’s not all of them. Dr. Deb Muth 00:18:49 Right. Bob Miller 00:18:50 So, maybe in the next year, we’re gonna come out with our third version of the chip. And then, if someone wants to get those new things that weren’t on it, they’d have to repeat. But whatever we measured is gonna stay the same. Dr. Deb Muth 00:19:03 That’s a lot of SNPs to look at. Bob Miller 00:19:05 Keeps us busy. Dr. Deb Muth 00:19:06 But there’s still, but there’s still SNPs that we. Bob Miller 00:19:09 That we’d like to have that we don’t have, so… Bob Miller 00:19:11 We started out with version 1 on our genetic test, then we worked with version 2, and we’re already compiling a list of what version 3 would look like. So if somebody has our version 2, And we’re saying, you know what, it’d be nice if we could see these, well, then you’d repeat, but it won’t change what you already know, so… Dr. Deb Muth 00:19:29 Got it, got it. So, when you started out, and you started looking at the research of Lyme disease and chronic infections, which detox pathways are most important for people who struggle with those conditions? Bob Miller 00:19:43 Okay. You know what might make sense as we do a screen share, and I’ll actually show you the pathway. Does that make sense? Bob Miller 00:19:48 Alright, so… let’s see if I… let me just press the share… Dr. Deb Muth 00:19:52 Yep, you should just be able to press share. Bob Miller 00:19:54 And… number 2. Okay. Are we seeing the screen there? Bob Miller 00:20:01 Okay. Dr. Deb Muth 00:20:02 So, this is a map that we made. Bob Miller 00:20:05 And by the way, this is not… All-inclusive of all the things we look at, but we believe this is a core issue. So, where we’re going to start here, there’s something called the microglia. And the microglia are glial cells. They’re in the brain and the central nervous system. And they’re very interesting little creatures, because most of the time, and this is just a drawing of what they sort of look like. Most of the time, they’re in what’s called the M2 anti-inflammatory mood. What that means, these little guys pick up dirt, debris, Recycle them. Turns on an enzyme called interleukin-10 that’s anti-inflammatory. And just kind of does general housekeeping. And just kind of does general housekeeping. However, when a trigger comes along. However, when a trigger comes along. They… it’s the same glial cell, but it moves over to a very pro-inflammatory enzyme. A pro-inflammatory glial cell. And it triggers these 3 enzymes, Actually, these four. That are pro-inflammatory. Tumor necrosis vector alpha, Interleukin-6. NF Kappa B, Inos. Now, these create inflammation. So you might think, well, why is that good? Well, if you have some foreign invader, virus, bacteria coming in, parasite. If you didn’t have these guys coming to the rescue, you would just die of infection. So, these guys are your friend unless they’re your worst enemy. Because TNFA, and we’ll show you when we actually do a demo account, TNFA can be overactive. So, in other words, it over-responds. Interleukin-6 can be overactive. And if Kappa-B can be overactive. The INOS, and I’ll explain each of these as we go through a demo, can be overactive. Now, what that means is, you’re very good at killing virus and bacteria. But this is where autoimmune disease comes in, and just inflammatory conditions. Now, this is just speculation, but we think what happened is, as you know. Thousands of years ago, we didn’t have refrigeration, we didn’t have sewer, we didn’t have pure water, and we didn’t have antibiotics. So, if you made it to 40, you were an old-timer, because everybody was dying of infection. So, what we believe happened is, by what’s called natural selection, Having these overactive. A thousand years ago was to your advantage. Dr. Deb Muth 00:22:31 Hmm. Bob Miller 00:22:32 But now… We have pure water, we have refrigeration, we have sewers, we have antibiotics. But now we have environmental factors that are stimulating them. Now it’s to our disadvantage. And we’ll talk about that a little bit as it relates to the hemochromatosis genes and maybe the G6PD. Dr. Deb Muth 00:22:48 Yep. Bob Miller 00:22:49 Now, why are we becoming so inflamed? Let’s look at the triggers. Now, one of my, favorite expressions is. I was born all the way back in 1954. Dr. Deb Muth 00:23:01 And it was a different world back then. Bob Miller 00:23:05 These are some of the triggers. And we’ll get into these, but right now, high fructose corn syrup, And the high-fat diet. High fructose corn syrup only came about in 1968. So now we’re being exposed to high fructose corn syrup. Then… we didn’t have these, these viruses like COVID. Dr. Deb Muth 00:23:26 Yeah. Bob Miller 00:23:27 Now, there’s now pretty strong evidence that COVID Was actually, you know, made as a gain of function. It’s debated, and I’m not taking an opinion on it, but there’s some people who believe Lyme disease was also a part of experimentation. Dr. Deb Muth 00:23:40 Go. Bob Miller 00:23:41 Then we have molds, and it appears as though mold is getting stronger. you know, 20 years ago, when I was seeing folks, mold wasn’t on the radar. I would say 7 out of the 10 folks we speak to today have mold problems. Yeah, 20 years ago, we talked more about mold allergy being an issue versus mold toxicity being an issue. Right. So… I know some folks are, you know, speculating what’s happening, but one of the theories out there is that EMF is strengthening mold. I don’t know if you ever heard that theory, and I don’t… Dr. Deb Muth 00:24:13 I have. Bob Miller 00:24:14 I’m not claiming it’s true, but it’s an interesting theory. Then even, you know, your black mold from water-damaged buildings. Then our air pollution is getting worse. We’re getting more toxic metals. Dr. Deb Muth 00:24:26 You know, if we have a… Bob Miller 00:24:27 You know, we’re gonna look back someday and say, what were we thinking, smearing aluminum into our armpits? The, what were we doing putting mercury in our teeth? Then, you know, glyphosate. When I was a kid, there was no glyphosate. So, all of these herbicides and pesticides. Polychlorinated biphenols, And then EMF. So, we love our cell phones, you know, and I think unless you, or in the middle of the desert, or down in a cave, you’re being exposed to EMF somewhere. So, you know, we have our cell phones with us, we have, We have Wi-Fi, the towers are everywhere. And we don’t know long-term, but we may find that this can… this creates some inflammation. And I don’t know if you get any folks, but do you have any folks that have… are they EMF sensitive? Dr. Deb Muth 00:25:16 Oh yeah, we have a whole bunch of them. Bob Miller 00:25:18 Yeah, and then if you have any TBIs, So, plenty of things here. that will stimulate into the microglia, M1. Now, you could say, well. We’re all pretty much exposed to the same thing. Why do some people get hit harder than others? So here’s where we’re gonna start. There’s an enzyme called Nrf2 and RF2. And Nrf2 is the enzyme that senses when there’s inflammation. And turns on hundreds of anti-inflammatory enzymes. We’ll show when we do the demo, you can have genetic weakness on NERF2. And NERF2 inhibits and slows down microglia M1. supports M2. Now, if it’s not complicated enough, there’s an enzyme called KEEP1. And KEEP1 inhibits NRF2. And you can actually have gain of function on keep 1, that makes Keap 1 stronger. So… A lot of the people who land on my doorstep So… A lot of the people who land on my doorstep Both parents gave a mutation on KEEP1, making it overactive. Both parents gave a mutation on KEEP1, making it overactive. Dr. Deb Muth 00:26:31 Hmm. Dr. Deb Muth 00:26:31 Hmm. Bob Miller 00:26:32 Suppressing Nrf2, nerve 2 might be weak. So, nobody’s putting the brakes on, M1. And by the same token, Nerve 2 supports M2. Then there’s a process called mTOR and autophagy. mTOR stands for mammalian tard of rapamycin, the growth of new cells. And then autophagy, taking our dead cells and recycling them. We need a balance between the two of them. If we didn’t have mTOR, the sperm and the egg would never become the baby, the baby would never become the adult, we wouldn’t make new cells. But our cells are constantly, you know, the old cells dying off. Autophagy is where we take that debris from the cell and recycle it, just like a farmer Plows the crop under at the end of the year. The dead plant then becomes the fuel for the spring, your dead cell becomes the fuel for the spring, and that’s autophagy. So we’re gonna look back someday and say, what were we thinking? We give our animals growth hormones so they get fatter faster. Oh my. So, we consume those animals, and inventory runs faster. Now, for anybody who’s, You know, maybe above 40, 45 years old. Think back when you were 12, and what did girls look like? They were primarily flat-chested little girls. Now they look like 16-year-olds. Because environmentally, we’re jacking up mTOR. So, mTOR stimulates microglia M1, suppresses microglia M2. Probably 80% of the folks we visit with. This is the part of the problem. NRF2 is weak. mTOR is strong. Environmental factors come along. And this guy gets carried away. He doesn’t do that burst and move back. Stays here. We’re calling that How environmental factors create a locked-in, pro-inflammatory. and neurotoxic phenotype. In other words, once it starts, it just keeps… Feeding upon itself. Alright, so what happens now when microglia is overactive. it triggers these 3 enzymes, TNFA, N of kappa B, And interleukin-6. Each one of these can have genetics that make them run stronger. Then it stimulates an enzyme called NLRP3, Which makes what are called inflammasomes. Now, guess what inflammasomes can be? Your best friend or your worst enemy? Because they will, if you’ve got, again, a virus or bacteria, or possibly even some bad cells in the body. They will zap them. Well, that’s good. Unless it’s overactive. Unless it’s overactive. And then what it does, through interleukin-1 beta, makes excess glutamate. And then what it does, through interleukin-1 beta, makes excess glutamate. Anxiety, gut inflammation, OCD, ADD, autism. And, you know, glutamate, we’ll talk about that a little bit, but glutamate makes you intelligent, highly motivated go-getter. but can also be excitatory. And then, look what it does. Let’s see, do I have the drawing tool here? Yes, I do. Okay. So, it comes down through here, Makes the glutamate. Comes back up through here. through the ADORA 2A enzyme, Then we’ve got a feedback loop that feeds upon itself. Then, through interleukin-18, we make histamine. and mast cells. And then through histamine receptor site number 1, we come back and spin it. And now you’ve just got this spinning feedback loop. So, the glutamate will make you anxious, the histamine will give you allergies and make you anxious. And you’re allergic to everything, and you’re feeling horrible. Now, it doesn’t end there, Dr. Dad. It then goes on to make something called gast dermins that creates pyroptosis, where it actually starts punching a hole in the cell membrane. And you’re only going to be as healthy as your cells are. Just a little background. You know, we’re made up of trillions of cells, and each one of them has what’s called a lipid bilayer, made from lipids, which comes from fats. And you’re only going to be as healthy as those membranes are. So that’s why we coined an interesting phrase. Cellular CPR. Construct the cell. Protect the cell. And restore the cell membrane. And we believe that’s going to be revolutionary in the functional medicine world. So… It’s not hard to figure out that if you start punching holes in the cell membrane, that’s not a good thing, okay? Bob Miller 00:31:22 Now… There’s an interesting molecule called NAD. Thicotide adenoside dinucleotide. And anybody who’s in the, you know, listening to the health podcasts and things, they’re… They’re, they’re learning about NAD. And I’m going to show you a chart later, all the good things that NAD does, but For the most part, it helps what’s called sirtuins. And sirtuins are quite interesting. If anybody’s looking at longevity. The sirtuins is where they’re looking at.Because sirtuins turn on good things. Turn off bad things. And I’ll show some charts on that later. So for right here, this sirtuin uses NAD, to slow down NF-kappa-B. CERT 2 uses NAD to slow down an ORP3. So, if we’ve got genetic weakness on these, or we don’t have enough NAD, We don’t hold this pathway back. Make sense? Dr. Deb Muth 00:32:24 Yeah, makes perfect sense. Bob Miller 00:32:25 Now, I’ll show this a little bit later. So, people are like, oh, well, I’m gonna start taking some NAD. Dr. Deb Muth 00:32:31 Right. Bob Miller 00:32:32 And there’s functional doctors who give NAD intravenous. It was just this morning, I was talking to a woman who said, Oh my gosh. I went and got intravenous NAD, and it took me a month to recover from that. Dr. Deb Muth 00:32:45 Hmm. Bob Miller 00:32:46 what happens is, and I’ll show this in a little more detail, there’s an enzyme called CD38, that’s stimulated by NF-kappa-B. And it takes NAD, To make intracellular calcium. that stimulates NLRP3 and actually makes things worse. So, if we have this guy upregulated, and I’ll show a chart what does that. taking NAD will make you worse. Again, when I go into the software, I’ll show you that whole pathway, so… I would encourage people, you know, just don’t go out and start taking massive amounts of NAD, you know, stick your toe in the water, see how you do. Because everything you’ve heard about, how good it is, is true, unless this guy says, oh, thank you very much, let me make more inflammation. Now, this might be part of our innate immune system, that if we have some pathogen that’s gonna kill us. By golly, we want that to happen. But if this is happening by environmental factors, Then it’s detrimental. So the immune system that protected us a thousand years ago now might be turning on us because of the environmental factors that we showed earlier. All right. Then there’s an enzyme called PARP that’s NAD-dependent, and that actually repairs strain breaks in your DNA. Now, the next thing that happens… is there’s an enzyme called NADPH oxidase that gets stimulated. and something called INOS. Now, I’m sure most people know about nitric oxide. It’s a gas that dilates your blood vessels. That’s why sometimes they’ll even give people drugs, nitroglycerin, to boost their nitric oxide. That’s why people are doing beetroots and other things to boost their nitric oxide. But there’s an OS3 enzyme that makes the nitric oxide that’s good for blood flow. But there’s an INOS That makes nitric oxide to kill pathogens. probably might be the third or fourth time I’ve said this. That’s a good thing, unless it isn’t. So, if it’s killing some pathogen, great. It was just misfiring. it combines… With superoxide that’s made by this enzyme, and makes something called peroxynitrite, which is one nasty free radical that chews you up and spits you out. So, the NOx enzyme, NADPH oxidase, uses NADPH, To make this free radical called superoxide. If we have time, we’ll get into it. NADPH is what your body needs to recycle your antioxidants.So, I coined the phrase, the NADPH steel. Where the NOX enzyme takes this very important NADPH, And rather than being useful, makes superoxide. Now, again, is that fine if you’ve got some bacteria to kill? Of course. But if it’s just chronically running, it’s just making all this chronic inflammation. Then it makes something called hydrogen peroxide. And we need to clear hydrogen peroxide by 3 enzymes, catalase, thyroid reduction. And glutathione peroxidase. If we have genetic issues on here, or we don’t have the cofactors. There’s something called the Fenton reaction, discovered in 1895 by Dr. Fenton. Where hydrogen peroxide combines with iron to make what are called hydroxyl radicals. And guess what they do? They create lipid peroxides, That damages your cell membranes. Now, again, the body’s pretty darn amazing. We have glutathione, And here’s where your body’s taking glutathione and recycling it. But look who’s needed to recycle it. NADPH. So, if this guy up here is chewing it up, We don’t recycle our glutathione. And then an enzyme called glufon peroxidase 4, Takes this damaged lipid and repairs it. So, here we’ve got this protecting, we want to protect it by not having this happen. But then we also need this guy to do the restoration. So, there’s a lot that can go wrong in here, Dr. Deb. Dr. Deb Muth 00:37:07 There’s a lot that could go wrong. And I can imagine some of my listeners are thinking that lipid peroxidase, is that the same thing as what they’re thinking of when we talk about lipids and cholesterol? Is that the same process that’s happening there? Bob Miller 00:37:22 Well, no, no, the lipids can be used to make cholesterol, but here we’re talking about where they’re going to build the cell membrane. And they’re being… and they’re being, destroyed. If anybody would like to see a visual representation of this, just go on YouTube. And type in, ferrooptosis Animation. cool little video, it’s about 3 minutes long, and it shows the lipids coming over, being oxidized, and now GPX4 fixes them, so… YouTube, Pharaoptosis Animation, cute little video. It’s just that really… Shows vividly what we’re… what we’re talking about here. Now, this is… Dr. Deb Muth 00:37:59 And so this is very common, too. Like, a lot of people do hydrogen peroxide IVs. Dr. Deb Muth 00:38:04 And so, if somebody doesn’t know their genetics, they could have a problem with doing those, just like they could doing the NADHIVs, correct? Bob Miller 00:38:13 Sure, yeah, yeah, yeah. So, I’ve talked to so many, you know, of course, the hydrogen peroxide kills pathogens. I mean, that’s what it does. So… but I’ve spoken to so many people that said. I had one client that said they’ve never been the same after having one hydrogen peroxide infusion. Dr. Deb Muth 00:38:30 Interesting. Bob Miller 00:38:31 Yeah. So… it can be… I see why people use it, because it. Bob Miller 00:38:36 pathogens, But on the other hand. And now’s a good time to speak about… I don’t have it on here, but there’s a, there’s an enzyme called the HFE gene. And that is what causes you to absorb iron. And there’s mutations in it that cause something called hemochromatosis. Were you overabsorb iron? Now, true hemochromatosis is when both parents give you a mutation. But there’s now growing evidence even a heterozygous can cause a little bit more iron absorption, not to the human chromatosis point, but overabsorption. So, if you overabsorb iron, And you have too much hydrogen peroxide that’s not cleared, All kinds of inflammation. Now, what’s happened is sometimes this inflammation Will damage the red blood cells. And some well-meaning doctor says, oh, you need some iron. And they take iron and it makes it worse. So, can’t tell you how many people I’ve said, you’ve got the overabsorption of iron, and they say, well, that can’t be right, because I’m low in iron. Well, that could be because it’s being chewed up here. Dr. Deb Muth 00:39:40 Sure. GPX1 and TXN turn it into, to water. The, catalase turns it into water and oxygen. Dr. Deb Muth 00:39:58 Now, I see a lot of my clients who have mutations or SNPs on that GPX gene, on that glutathione gene. And they really struggle to clear a lot of their toxins. Bob Miller 00:40:12 Sure. Dr. Deb Muth 00:40:14 Yeah, absolutely. Well, GPX4. Bob Miller 00:40:18 is what, repairs, but you can see GPX1 Is what uses glutathione. To turn hydrogen peroxide. So, but it all depends upon having enough glutathione. Dr. Deb Muth 00:40:30 Yeah. Bob Miller 00:40:31 Well, guess who controls making a glutathione? Dr. Deb Muth 00:40:34 Nerf 2. Bob Miller 00:40:37 So, if you have a keep one weakness, or strength to two… I’m sorry, keep one is too strong. Nrf2 is too weak. You don’t make glutathione. So, when a lot of people do that, it’s like, well, I’m gonna take glutathione. Dr. Deb Muth 00:40:51 Right. Bob Miller 00:40:52 And some do great, and some do poorly. You know, because… and I’ll show this on one of the other charts. You can see here that the, The glutathione has to be recycled. And if we don’t recycle it, it actually turns into superoxide free radical. So… NADPH are the cofactors, For taking the oxidi… here’s oxidized glutathione, here’s reduced. So, this is a good glutathione. After it does its job, you can see it becomes oxidized.We need to recycle it. Well, if we have weakness on the enzyme that does that, or a weakness in Nrf2, or not enough NADPH. The oxidized glutathione never gets recycled. So, I’ve talked to a lot of people who said, oh, glutathione made me so sick, and say, well. Dr. Deb Muth 00:41:43 Yeah. Bob Miller 00:41:44 You need it, but you need to recycle it. Dr. Deb Muth 00:41:46 Can you speak for just a brief moment, too, about MTHFR? That is a very popular gene, it’s all over social media as the major gene, but can you speak to a little bit about that, and how that fits into this whole process of things? Because it is just such a small piece. Dr. Deb Muth 00:42:04 understanding genetics. Bob Miller 00:42:06 Yeah, to be honest, it drives me nuts. Dr. Deb Muth 00:42:08 Me too. Bob Miller 00:42:11 Alright, so… You know, there are people on social media I won’t say what I think, I’ll be kind. But… But the, And, you know, they might mean well. But they talk about, if you have MTHFR and COMT and PEMT, that’s… oh my goodness, that’s horrible, and we’ll fix that for you, and you’ll be fine. Bob Miller 00:42:36 it just irritates me to no end. And it really could get anybody who’s doing this legitimately in trouble. I mean, I’m afraid someday, you know, there might be some cracking down on this kind of nonsense. Now, to answer your question about MTHFR. Dr. Deb Muth 00:42:51 I mean, it really is, but I’ll tell you what, why don’t we hold that thought until I go to another map and I can actually… Okay. Bob Miller 00:42:56 But the real… the cliff notes is the MTHFR puts a methyl group on your folate, which is needed, but it has gotten way, way, way too much attention. And people learn they have MTHFR, and they start taking a multivitamin with methylfolate, then they take a B vitamin with methylfolate. Dr. Deb Muth 00:43:13 And they’re pushing it too hard. Bob Miller 00:43:15 Yeah. So I can’t tell you how many people I’ve helped by saying, stop it. Dr. Deb Muth 00:43:20 Yeah, take less of it. Bob Miller 00:43:21 Take less of it, yeah. So, yeah. Yeah, there’s a… If somebody, say, ranked the enzymes at their level of importance, MTHFR might be 40 or 50 on a scale of 100, you know. Keep one Nerf two. big deals. Dr. Deb Muth 00:43:40 deals. Bob Miller 00:43:41 NQO1 that I didn’t even talk about yet, NQO1, takes your, NA… your NAD goes into NADH, To make electrons for the electron transport chain. you need NQ01 to bring that back. If that’s not working, and I’ll show you on the NAD map how disastrous that can be. Now, the next piece is here, and I think You know, if you talk to any school teachers and say, if you’ve taught for more than 10 years, how are the kids today? Every one of them says, more ADD, ADHD, more autism. Just look at human beings, we’ve never been so agitated. You know, everybody, and it might be a social media thing, but people take a position on something, and if anybody doesn’t share that position, they view them as the enemy. Dr. Deb Muth 00:44:29 And it’s kind of scary what’s happening to us. Bob Miller 00:44:33 So, we can’t agree to disagree anymore. We see anybody who has a differing opinion as the enemy. And, you know, there was… there’s people that didn’t have Christmas dinners together, because they had political differences, like… Dr. Deb Muth 00:44:44 Excuse me. Bob Miller 00:44:45 can’t you put your political differences aside to have Christmas together, you know? Dr. Deb Muth 00:44:49 Right? Bob Miller 00:44:50 become that, you know, no matter what your position is, and I’m not saying anyone’s right or wrong, I’m just saying. You know, in the old days, they used to say that the Republicans and Democrats in Congress would argue policy and then go have dinner together. And now everybody’s all up in arms, angry. Dr. Deb Muth 00:45:05 Yeah. Bob Miller 00:45:06 So… There’s likely multiple reasons for that. But let me show you one of them. That, you know, to what degree this is… very important, we don’t know, but I think We’re beginning to believe this is very important. So, there’s something… there’s a neurotransmitter called GABA. And God buys the don’t worry, relax, be happy. Chill. Okay. Dr. Deb Muth 00:45:31 Nobody has enough of that anymore. Bob Miller 00:45:33 Well, yeah, you’ll be surprised what I’m gonna show you. So, let me see if I can find a, Let me see if I can find the right slide here. Let me look for it here. So, there’s something called a GABA receptor site. And here you can see… This is a neuron, and this is where you, The neuron normally is excitatory. However, there’s normally low chloride in the neuron. Dr. Deb Muth 00:46:09 Hmm. Bob Miller 00:46:10 So, GABA itself is neither relaxing. For excitatory, all GABA does, it opens up what’s called a chloride channel. And then chloride, which has a negative charge, will flow into the neuron. Follow me there? Dr. Deb Muth 00:46:26 Yep. Bob Miller 00:46:27 And as it does, it changes this from a positive charge to a negative charge, And it’s relaxing. and inhibitory. Dr. Deb Muth 00:46:34 Hmm. Bob Miller 00:46:36 Now, on the other hand, there’s enzymes called NKCC1, That will push chloride in. and KCC2 that will bring chlor… oops and bring chloride out. And then there’s a sodium channel. And, sodium has a positive charge. And glutamate will push that in. So, as long as this is happening. And GABA says, receptor sites, open, chloride goes in, Chill. However, If NKCC1 Pushes extra chloride in. KCC2 doesn’t pull it out. and GABA hits the receptor site, the GABA comes flowing out, Sodium comes in, And now it’s excitatory. So Gabba didn’t change. GABA just opened the receptor site, that’s all it does. Dr. Deb Muth 00:47:33 Yeah. Bob Miller 00:47:34 But it’s the chloride balance that’s going to determine whether this is relaxing or not. Now, these are the things that go along with when they lose that KCC2 or gain NKCC1. Pain and sensitivity, burning electrical, neuropathic pain. Normal touch hurts. Sound and light sensitivity. Tinnitus can flare. Headaches and migraines. Seizure tendency. Body jolts. Spasticity, cramps, stiffness, startle reflex. Trouble falling asleep, non-restorative sleep. Anxiety, stress, reactivity, that’s what we have now. Hyperarousal, panic-like surges, irritability, racing thoughts. Brain fog, slowed processing, working memory slip-ups. Mental fatigue. Episodes of racing hearts, sweaty palms, guts on edge. Those are all the things that happen when this GABA switch occurs. Now, here’s what happens, and this is what I’m going to be presenting at an autism conference. When you have a newborn, they need that NKCC dominant to develop. By early childhood, it should… or, sorry, early adulthood. we should move over to the KCC dominant, that’s the taking the chloride out. Nice-looking 25-year-old boys, functioning very well. However, when we get microglia M1 upregulated. Because of environmental toxins, processed foods, Tylenol, aluminum. they stay in NKCC1 dominant, and there’s ADD, ADHD, Autism, the whole spectrum. because… They’ve not moved over to the… They’ve not moved over to the KCC2. And again, this is caused by… Environmental factors. Stimulating the microglia. And then, interleukin-1, interleukin-18 weakens KCC2, interleukin-1 beta, Strengthens NKCC1. high chloride. We open up the chloride channel, In Rebell Excitatory. So, I think when, When the pediatricians get ahold of this, they’re going to be very excited to know that This could be why we’re seeing such a rise, and not just autism, but ADD, ADHD, anxiety, the whole shit mess. Dr. Deb Muth 00:49:58 thing. Bob Miller 00:49:59 Yeah, so… and you can see NF-kappa-B stimulates that. These stimulate it, and I think that’s why everyone’s getting so anxious. Now, there’s a little bit more to it, and we’ll get into this when we look at some of the maps, but… The, the glutamate, Which is excitatory. will stimulate the NMDA receptor, make more glutamate, And glutamate will inhibit KCC2. And then we also need an astrocyte To, take both ammonia And glutamate, and… Turn them back into glutamine. And I’m going to talk to you a little bit about arachidenic acid, and if we have too much arachidenic acid. or TNFA is upregulated, that doesn’t happen. Ammonia goes up, and there may be multiple reasons for this, but this is a reason why some of the autistic kids do flapping. Dr. Deb Muth 00:50:49 Hmm. Bob Miller 00:50:50 Because they’re not clearing their ammonia. And you can tell if somebody has high ammonia by… they get that old person smell, you know. Dr. Deb Muth 00:51:00 Yup. Bob Miller 00:51:01 your vehicle cycle’s not taking out the, the ammonia. Now, last pathway here. There’s growing interest in mast cell activation. So, back here, we talked about peroxynitride. And that will stimulate mast cells, and those are white blood cells that are your best friend, unless they’re your worst enemy. Then it’ll make histamine. And there’s enzymes called histidine decarboxylase that’ll make more. Dr. Deb Muth 00:51:28 I’m sure everybody’s heard of DAO, the enzyme that degrades histamine. Yep. Bob Miller 00:51:31 We can have genetic weakness, we don’t make that. There’s an enzyme called histamine and methyltransferase, That, That breaks down the histamine. Then if we don’t do that, it’ll get stuck in the histamine receptor site. And then it’ll make something called, renin. Which will cause angiotensinogen to turn into angiotensin. One, that turns into angiotensin II,And that’s where people make aldosterone, where they’ll get the, The swollen ankles and high blood pressure. But interestingly, there’s an enzyme called ACE2, that takes this guy and turns it into angiotensin 1-7, Which is anti-inflammatory and also inhibits… TNFA. Now, you can have weakness on ACE2, But… and anybody’s saying, that sounds familiar? Dr. Deb Muth 00:52:25 That’s where COVID comes in, using ACE2. Bob Miller 00:52:28 And now we just found there’s literature that if you get COVID long enough, it can actually make ACE2 not be able to work as well. So look what it does. It comes down here, stimulates the NADPH oxidase, More superoxide. More peroxynitrite. And we’re on a cycle here. We’ve actually named this the Home Cycle Hypothesis, the proposed feed-forward loop. That just keeps feeding on itself. All being caused by… Primarily, The environmental factors. But hitting those who have genetic weakness the hardest. That’s why. Dr. Deb Muth 00:53:08 To the people. Bob Miller 00:53:09 Don’t live in a moldy house. One person is sick as can be, and the other person says, well, you must be imagining things, because I don’t feel anything. Dr. Deb Muth Yeah. Same thing with long haul, right? Two people can both get sick, one gets sick and never seems to recover, and somebody else gets sick, and they have absolutely no problems with it at all. Bob Miller 00:53:30 Sure. Well, think about it, if you get COVID, and ACE2 is weak, and some of this other stuff is going on. This thing just starts feeding upon itself. Dr. Deb Muth 00:53:38 Keep creating more inflammation, more complications, nothing’s calming down. Bob Miller 00:53:43 Yeah. Now, you, you ask about, MTHFR. So, this is the, this is the, the software called Functional Genomic Analysis. There’s a demo report we have. So, let’s talk a little bit about, MTHFR. So, we actually have a map called a methylation map. Now, what happens is, when you do your saliva test, you, you know, you spit, you put some saliva. in a collection kit, goes to a lab, takes out the DNA data, sends it to the computer, and now you can actually see it visually. Okay. So, it’s gonna take a second for this, data to load up, it’s, and each of these Circles, each of these ovals, is an enzyme. And the data gets loaded up to see where it is. So, until it gets loaded up here, I didn’t preload this. There it goes. So… The primary thing about methylation is There’s a nasty substance called homocysteine that, if it’s too high, can really be detrimental. The body takes methylfolate, and combines with methyl B12, To bring this back up to methionine. And then through the MAT genes, we make SAMI, S-adml methionine. Which is involved in so many processes. Then after it does its thing, it turns back into homocysteine. And this thing needs to keep spinning around. That’s why, you know, it’s a good idea to keep homocysteine at, do you have a number that you’d like? 7, 8? What do you like for a number? Dr. Deb Muth 00:55:24 Yeah, I like mine below 7. Bob Miller 00:55:26 Yeah. So if the homocysteine goes too high. It, caused all kinds of problems. So, here’s where you ask about the MTHFR. So, here you can see on this individual. I click on MTHFR, and you can see it comes up here, here’s the C677. And you can see here where it says, variants. I’ll… I’ll draw in case somebody’s having a hard time seeing that. So, you can see there’s nothing in there. That means there’s no genetic mutations. If one parent would have given a mutation, there’d be a 1. If both parents did, there’d be a 2. Now, here’s why Yes, methylation is important, I’m not saying it isn’t important, but look at this MTHFRC677. In my software. Only 42.5% of the population does not have a mutation. 44.7% have won. 12.9 have 2. So, this isn’t some rare, oh my god, I’m gonna die… Kind of thing, yeah. Dr. Deb Muth 00:56:27 Right. Bob Miller 00:56:28 So, And then what happens is that, and again, I’m not dismissing methylation, I… we could do a whole show on methylation. Bob Miller 00:56:36 get it. But I think that what people are doing is they’re, they’re learning about MTHFR, they get it measured, they panic. They start taking massive amounts of methylfolate, which many times is to their detriment. Dr. Deb Muth 00:56:50 Well, it’s… and isn’t it true, too, with MTHFR, like, you have to also look at MTR, MTRR, and the more we stack up of those, the more complicated than MTHFR can be. It’s not… it’s not as simple as just saying MTHFR 677 versus 1298. It’s more complex than that, kind of like what you’ve already shown with some of the other things. There’s more to it than just that one little sliver. Bob Miller 00:57:17 Oh, sure, well, let’s take a look. So, remember I said there’s a cofactor? One of the cofactors is called FAD. Just a Bob Miller observation, that’s all. But when people have trouble with their riboflavin and they don’t have enough FAD, They’re doing much worse than people who have just a C677. So, right here, you could have perfect C677th. And if you don’t have the cofactor, it’s not gonna work, okay? Dr. Deb Muth 00:57:48 And as you said, there’s an MTR enzyme. Bob Miller 00:57:51 that takes methylfolate and methyl B12, to spin it around. So, here on this individual. here’s your… here’s your B vitamins, or I’m sorry, your B12s. There’s an enzyme called TCN1 that takes it from the stomach into the blood. Then there’s other enzymes that take it from the blood into the tissue. And if you’re having trouble here. Well, then you’re not going to have this working, so… Even if you don’t have MTHFR, And you have MTR, like this, no, I’m sorry, this person doesn’t. But they have the MTRR, and then they don’t have enough B12, this isn’t gonna work, aside from that. And then there’s a middle pathway. And then there’s enzymes called the MAT1. they take the methionine to the salmon. If that’s not working, we stick… we get stuck in methionine. So, it’s, it’s not just an MTHFR. And then, one of the things that people forget about. is through these CBS enzymes and CTH, We make cysteine, which is needed to make glutathione. The master antioxidant. So, it really is that… I call it the, The 3D chess game played underwater. Dr. Deb Muth 00:59:07 It really is. I mean, I see people who have CVS, COMT, glutathione, MGHFR genes. And some of them function just fine. Like, they have Like, I look at this person and I’m like, oh my gosh, I don’t know how they’re functioning because they’re double mutated on so many pathways, but yet they don’t have a lot of symptoms, they don’t have a lot of complications. Somehow their body has figured out a way to adapt to what it has so it can stay alive and it can function at a high functioning level. Bob Miller 00:59:36 Yeah, and they may be, you know, eating right? Yeah. Staying out of a moldy house. reducing stress. So, it’s diet, it’s stress, it’s genetics, environmental factors. So, yeah, we can’t just say somebody’s gonna be good or somebody’s gonna be bad. You know, some people get scared, oh, I got all these, it’s like, well… Bob Miller 00:59:56 Are you living in a moldy house? You know, and if you live in a moldy house and your glucuronidation pathway doesn’t do well, or if you’re, you know, a smoker, or you’re constantly eating junk food, I mean, all. Bob Miller 01:00:07 things come together. Although, you know, when we focus on genetics, we’re well aware that this is just a piece of it. You know, you could have identical twins, Genetically, and if one… Is exposed to mold and smokes and drinks and stressed out. They’re gonna be a whole lot sicker than their sibling. Bob Miller 01:00:28 Yep. Dr. Deb Muth 01:00:29 Yeah, it’s that concept of taking twins, and one gets raced with one family, and one gets raced with another family, and they don’t have the same… problems that… that each other have, you know? It’s a very unique situation, we don’t think about that enough. Bob Miller 01:00:44 Alright, so again, genetics loads the gun, environment pulls the trigger. So, if you’ve got a loaded gun, but you don’t have the triggers, you’re okay. Dr. Deb Muth 01:00:53 Yeah. Bob Miller 01:00:54 Yeah. So, remember I said I was going to talk about NAD? So, here’s NAD, and what it does, it turns into NADH. And what NADH does, it, Comes down this pathway, what’s called the electron transport chain. And that makes your ATP, that’s your energy. So, if this wasn’t working, we wouldn’t be alive, because we wouldn’t have energy. So it donates an electron, that’s why it’s called electron transport chain. So, we need NAD, To make this, to make the energy. But remember I said that NQ01, this would probably be, like, on my top 10 list of… Bob Miller 01:01:36 Much more important than MTHFR. This one takes NADH back to NAD. If we’re stuck over here, We’re low in this NAD+, But what happens is, NQO1 also provides CoQ10. And CoQ10 Is what’s needed for the electron transport chain to flow. So if we get too many electrons up here. And they don’t turn them into energy. They make a nasty free radical called superoxide. Okay. Now, NAD plus also makes NADPH, And that is needed. Remember I said we need to recycle our antioxidants. So, if we have a problem with FAD from riboflavin. Yeah, we don’t have enough NADPH, Glutathione’s not getting recycled, and you’re gonna be inflamed. And you take glutathione, you’ll feel worse. There’s another enzyme called thimoredoxin. Same thing, needs NADPH and FAD. And same way with your nitric oxide, there’s an enzyme called NOS3, That makes the nitric oxide that dilates your blood vessels. And if we don’t have enough NADPH or fat, You’re gonna make superoxide. Rather than nitric oxide. Now, remember

Hello everyone. Welcome to the latest episode of The Matchbox Podcast powered by Ignition Coach Co. I'm your host, Adam Saban, and on this week's episode we're talking about how to avoid progression stagnation, pedaling heel up vs heel down, and plyometrics.   As always, if you like what you hear, share this with your friends and leave us a five star review and if you have any questions for the show drop us an email at matchboxpod@gmail.com or head over to ignitioncoachco.com and fill out The Matchbox Podcast listener question form.    Alight let's get into it!   For more social media content, follow along @ignitioncoachco @adamsaban6 @dizzle_dillman @dylanjawnson @kait.maddox     https://patreon.com/MatchboxPodcast?utm_medium=unknown&utm_source=join_link&utm_campaign=creatorshare_creator&utm_content=copyLink   https://www.youtube.com/c/DylanJohnsonCycling https://www.ignitioncoachco.com  https://www.youtube.com/@DrewDillmanChannel   Intro/ Outro music by AlexGrohl - song "King Around Here" - https://pixabay.com/music/id-15045/    The following was generated using Riverside.fm AI technologies   Show Summary In this episode of the Matchbox podcast, the hosts discuss various topics related to athletic performance and training. They explore the factors that separate athletes who continue to improve from those who stagnate, emphasizing the importance of mental mindset and willingness to adapt training routines. The conversation also touches on the impact of age on cycling performance, with insights into how athletes can continue to excel beyond their physiological peak age. The hosts address listener questions about pedaling techniques and the benefits of plyometrics for cyclists, providing practical advice and personal experiences.   Timestamps 0:01 - Introduction and listener questions 0:29 - Discussion on athlete improvement and stagnation 2:38 - Impact of age on cycling performance 5:47 - Mental mindset and training breakthroughs 10:37 - Importance of regular blood work for athletes 18:38 - Listener question: Pedaling techniques 24:10 - Listener question: Benefits of plyometrics for cyclists 27:49 - Wrap-up and closing remarks

Welcome to Secrets of Organ Playing Podcast No. 772! Today's question was sent by Jerome and he writes:Hi Vidas,I'm an ardent listener of your podcast and a youtube channel.I have a quick question as it relates to pedal boards and practice. My church has the Rogers organ with the standard 32 pedalboard. However at home I have a smaller 25 note midi pedal board. I'm unable to practice at church consistently, because of work and distance .The question is does practicing on a smaller pedal board ruin technique for standard pedaling. I'm new to the organ and have only been playing a year, but I'm a pianist before playing organ.Thanks for any feedback you might give, I can look forward to a podcast if you address this issue.Thanks Jerome Tulloch (from Jamaica)Here you will find all my scores: https://www.sheetmusicplus.com/en/category/arrangeme/?q=Secrets+of+Organ+Playing&aff_id=454957

March 13, 2026 - Angela Foulke of the Decatur Family YMCA joined Byers & Co to talk about Livestrong and Pedaling for Parkinson's at the Y, annoying advertising, and sports. Listen to the podcast now!See omnystudio.com/listener for privacy information.

Further Thoughts on Pedaling - Ep 186 A walking podcast in which I expand on my percolations about how to pedal a bike.    Some offer that you can't coach this activity. Their position is that by coaching someone on how to pedal a bike, the subject will suffer unintended consequences.    I cannot accept this as I believe that we control our limbs, and also that any movement program or engram has the potential to be re-written.    How do we influence our reality if not with intent?  Onward. 

The Boise Bicycle Project is gearing up for its biggest holiday giveaway yet, over 600 kid-dreamed bikes, and they're calling on the community to help turn those dreams into a reality. 

Send us a textI'm teaching my oldest daughter to ride a bike, and it is a lot harder than she expected. She keeps forgetting to pedal, so she stops moving forward, and that's when she tips over and falls. As Christians, our walk with Christ is much harder than many anticipate. But with God, all things are possible - we just have to keep moving forward. When we stop growing is when we will fall - we've got to remember to keep pressing on. #SetYourMindAbovePodcast

[DONATE WITH PAYPAL] Greg and Ed the Protestant dive into a lively discussion about the fading concept of sin in contemporary Protestant and Evangelical churches. They explore how the gospel's power hinges on the reality of bad news—sin's eternal consequences—before the good news can shine. Ed shares his recent experiences at a modern evangelical church, where sermons focus on self-improvement and "living your best life" rather than confronting sin head-on. Greg argues that this shift turns pastors and even Jesus into life coaches, diluting the urgency of salvation and the church's mission. With their signature blend of humor, insight, and orthodoxy, they unpack why a gospel without sin misses the mark. Tune in for a thought-provoking conversation that challenges the modern church's approach and teases an exciting announcement from Ed about his journey toward Catholicism. Donate with PayPal! Website: https://www.consideringcatholicism.com/ Email: consideringcatholicism@gmail.com

For more than 20 years, a self-proclaimed “Cycling Chef” has been giving two-wheeled gastronomic tours of the Danish capital, Copenhagen. He even cooks on the go, leading guests on a foodie adventure with his kitchen-bike. Pedaling through the streets of Copenhagen on his custom-built bicycle-turned-portable kitchen, chef Morten Kryger Wulff flips prawns in a frying pan while leading guests on a culinary tour with a twist. In a city famous for fine dining—including Michelin-starred restaurants Noma, Geranium and Alchemist—Kryger Wulff's five-course tour may be the most unique dining experience of all. “We have, over the last 20 years, been working on this concept, bringing people on gastronomic rides, cooking for them along the way. And that is what it's all about,” smiles Kryger Wulff. The Danish chef, who's worked in prestigious kitchens, including London's Savoy, first became the “Cycling Chef” back in 2002, cooking outdoors at private events, such as garden parties, corporate functions and picnics. The idea was born when he and his friends were turfed out of a Copenhagen royal park by a park officer for illegally barbecuing. With no other option, they placed the cast-iron grill onto his old vintage cargo bike and kept cooking. “Right there, while I was biking, and my friend was running alongside turning the steaks, we were looking at each other. You need that, you need a bicycle kitchen,” he recalls. Kryger Wulff now gives several “Gastronomic Rides” each year, pedaling through city streets and parks, then stopping at hidden spots to prepare and share food. That wouldn't be possible without his custom-built portable kitchen: an adapted cargo bike fitted with a stove, foldable work surface, fridges, cupboards, plus space for glasses, cutlery and more. Each tour includes five courses consumed at five different city stops. The experience lasts about four and a half hours, with guests cycling between three and five kilometers. It costs 1,695 Danish kroner (approximately $265) per person. Guests bring their own bikes or rent one if needed. Rain ponchos are even provided, though not always required. This article was provided by The Associated Press.

Dorian Anderson was a neuroscientist and geneticist with a promising academic career when he made a radical shift: in 2014, he left the lab to pursue a year-long, cross-country birding adventure—on a bicycle. Pedaling nearly 18,000 miles across the U.S., his goal was to spot over 600 bird species while deepening his sobriety, and reconnecting with nature. Connect with Dorian:WebsiteInstagramDorian's book, Birding Under the InfluenceRegister for Camp Monsters LIVE in Denver, ColoradoThank you to our sponsors: Capital One and the REI Co-op® Mastercard® Benchmade Hosted by Simplecast, an AdsWizz company. See pcm.adswizz.com for information about our collection and use of personal data for advertising.

Second Date Update: Back pedaling big time... See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

At 73 years old, author and adventurer Ken Reinke has proven that limitations are only in the mind.   Despite living with polio since infancy and managing diabetes, Ken has cycled over 9,000 miles across the United States—including solo rides from Florida to the West Coast.   In this inspiring conversation, Ken shares how to develop an adventurer's mindset, why the mind is often our greatest stumbling block, and the lessons behind his book The Road Spoke.   His story is a powerful reminder that resilience, perspective, and joy can carry us through life's toughest terrains.   Reach Ken: Ken Reinke ken.r.reinke@gmail.com ... Want to be a guest on WITneSSes? Send Elisha Arowojobe a message on #PodMatch, here: https://www.podmatch.com/member/ambelisha     Elevate your business with Anastasia's expert consulting. Use code Elisha3 for an exclusive offer and transform your business today! https://resurrectionmentor.wixsite.com/so/42PDEPEB8?languageTag=en   Feel like something's missing? Start Living the Magical Life today. Buy Now: https://a.co/d/4sHrFx2   Amb. Elisha just published a transformational workbook, buy now: https://ambelisha.gumroad.com/l/Llaenlap

We're getting into perfect biking weather, and in just a couple of weeks, Winchester's Marlowe Foundation hopes you'll join them for a very special ride. They're biking from Winchester up to Lake Sunapee, New Hampshire, all to raise money for some local non-profits doing important work with people who have intellectual and developmental disabilities. Stephen Roge, Co-Founder of the Marlowe Foundation, shares their story with Nichole and explains how you can take part.

Pauline Ferrand-Prévot's win at the 2025 Tour de France Femme was an incredible display of cycling prowess and dominance but also put women's bodies, health, and sporting double standards back under the microscope. Can women just be athletes? Or do they have to always been an athlete AND a model of health. This episode will leave you thinking about these questions and your own bias when viewing women and women's sports. You can support us on Patreon AND get access to members' only content by ⁠⁠clicking here⁠⁠. If you want to work with us, you can check out our ⁠⁠nutrition coaching⁠⁠ and ⁠⁠fitness programming⁠⁠. Learn more about your ad choices. Visit megaphone.fm/adchoices

Riding Through Pain, Pedaling Toward Power: Teri M. Brown's Double-Butted AdventureWelcome to The MISOGI Method, where we explore bold, life-changing leaps that push us beyond our limits and lead to transformation.Today's guest, Teri M. Brown, took an extraordinary journey to reclaim her life—by pedaling across the United States on a tandem bike.After surviving a stressful marriage, Teri's ride became a powerful emotional and spiritual adventure, leading her to healing and empowerment.Teri shares her journey in 10 Little Rules for a Double-Butted Adventure, a book that blends storytelling and life lessons with journaling prompts to help others live boldly.In this episode, Teri talks about overcoming pain, trusting your strength, and embracing adventures that rebuild your soul. Listen now and get inspired to take your own leap of transformation! Resources:Teri's book: 10 Little Rules for a Double-Butted Adventurehttps://www.terimbrown.com/Follow Teri: InstagramIncorporating cycling into your routine can be a powerful tool for emotional healing and creative expression. Whether through structured cycling programs or casual rides in natural settings, the physical activity and exposure to nature can promote mental well-being and stimulate creative thinking. As highlighted by Teri M. Brown's journey, embracing such adventures can lead to profound personal transformation.Become a supporter of this podcast: https://www.spreaker.com/podcast/the-misogi-method-experience-a-new-comfort-zone--2910681/support.

In June of 2018, two brave correspondents set out to make history. WNIJ's Carl Nelson and Dan Libman would be the first to bike the Rock River Trail. Pedaling 320 miles in just five days, they even managed to send dispatches out to listeners every morning. We revisit their journey.

Malcolm-Jamal Warner, who rose to fame as Theo Huxtable on "The Cosby Show," died while vacationing in Costa Rica. Warner, who was 54, is being remembered for his Emmy-nominated role, Grammy win and impact on Black representation on television. A federal court has thrown out Pedro Hernandez's conviction for the 1979 murder of 6-year-old Etan Patz. The ruling opens the door to a new trial in one of the nation's most infamous missing child cases. Former Louisville police officer Brett Hankison was sentenced to 33 months in prison for violating Breonna Taylor's civil rights. Taylor's family says the sentence is still too lenient, calling the DOJ's earlier recommendation of one day in prison "insulting." Dottie Dorion, a lifelong athlete and triathlete, rode her Peloton bike nearly 3,000 times before fighting to create a new age group for riders 90 and older. Her 14-month campaign finally paid off. Skyler Henry shares her story. The Morris B. Sanders House, the first modernist home in NYC, is up for sale for the first time in 50 years. Anthony Mason returns to the place he once called home. In her new book "Sucker Punch," bestselling author Scaachi Koul shares raw, funny, and honest essays about navigating life after heartbreak. To learn more about listener data and our privacy practices visit: https://www.audacyinc.com/privacy-policy Learn more about your ad choices. Visit https://podcastchoices.com/adchoices

Former BMX bro Devon Lampman turned his two-wheel passion into a maintenance gig at Barton Springs Bike Rental & Tours - eventually becoming a co-owner of the Austin, TX mainstay. Now if he can just find some qualified employees willing to work during their heavy traffic periods: weekends and vacations.See omnystudio.com/listener for privacy information.

Jeremy Bartosh: www.co.jackson.mn.us Randolph Briley: exploremn.com Erik Noonan: bikeMN.org RAGBRAI LII information: www.ragbrai.com Just Go Bike: https://ragbrai.com/justgobike/ Watch, or listen on our Just Go Bike YouTube channel. https://www.youtube.com/@JustGoBikePodcast Have a topic for a future episode? Message us at justgobikepodcast@gmail.com.

Leaving middle age and approaching retirement is often portrayed as a time to settle into comfortable patterns and perhaps explore grand adventures. The common view suggests that after you've spent a lifetime building satisfying relationships, now there's time to sit back and enjoy them, to lean into the habits you enjoy, to stop working so hard at everyday things. Unless everything in your world gets turned on its head and all the familiar, comfortable things start to disappear. What do you do if death or divorce, or both, kick your comfortable world into the gutter, if your golden years threaten to turn into lead? Is there an alchemy that can turn those lead years back into gold?   Szifra Birke and Jay Livingston feel they have done just that. They've forged a rich 25-year marriage from the detritus of four divorces and a spouse's death. In their insightfully revealing and quirky book, In Tandem: Pedaling Through Mid-life on a Bicycle Built for Two, they share how they took the scattered pieces of their two very different lives and worked to create a joint, satisfying experience where, as two very different people, they each could thrive. These two are both intensely committed to growing ever more aware of their internal speedbumps and the opportunities to laugh themselves into tears. About Szifra Birke and Jay Livingston: Szifra Birke is an Executive Leadership Coach and the country's first Financial Behavior Specialist. For her groundbreaking work with financial professionals and their clients, Szifra has appeared in Business Week, in addition to industry publications such as Investment News. In her first career, she co-authored Together We Heal, a book about psychotherapy for adults with parental alcoholism. She coauthored with Jay Livingston, In Tandem: Pedaling Through Midlife on a Bicycle Built for Two. Jay Livingston is retired from an eclectic career as an executive coach, a prize-winning antique boat restorer, a renowned dog behaviorist, and Director of Development for a Harvard Hospital. He is the author of Simple Steps to Change Your Business, Your Life. His dozen other vocations and avocations are a case study in excellence run amok. He has appeared on NOVA and, in the 70s, an automotive garage he managed was recognized by Ralph Nader. Get in touch with Szifra Birke and Jay Livingston: Buy Szifra and Jay's book:  https://revolutionizeretirement.com/tandem  Visit their website:  https://birkeconsulting.com/   What to do next: Click to grab our free guide, 10 Key Issues to Consider as You Explore Your Retirement Transition Please leave a review at Apple Podcasts. Join our Revolutionize Your Retirement group on Facebook.

Fluent Fiction - Hindi: Pedaling Through Kaziranga: A Quest for Elephant Encounters Find the full episode transcript, vocabulary words, and more:fluentfiction.com/hi/episode/2025-06-12-22-34-02-hi Story Transcript:Hi: काज़ीरंगा नेशनल पार्क की हरियाली के बीच, रोहन और मीरा अपनी साइकिले चलाते हुए आगे बढ़ रहे थे।En: Amidst the greenery of काज़ीरंगा National Park, रोहन and मीरा were pedaling their bicycles forward.Hi: गर्मी का मौसम था और सूरज की तेज़ किरणें चमक रही थीं, परंतु उनके दिल में उत्साह की कोई कमी नहीं थी।En: It was the season of summer, and the sun's rays were shining brightly, yet there was no lack of enthusiasm in their hearts.Hi: आज उन्हें हाथियों के झुंड को देखना था और रोहन के कैमरे को सही चित्र कैद करना था।En: Today, they had to witness a herd of elephants and रोहन needed to capture the perfect picture with his camera.Hi: रोहन प्रकृति प्रेमी था।En: रोहन was a nature lover.Hi: उसे जानवरों की फोटो खींचने का पुराना शौक था।En: He had a long-standing passion for photographing animals.Hi: "हाथियों का संरक्षण जरूरी है," यह बात वह हमेशा कहा करता था।En: He always used to say, "Conservation of elephants is necessary."Hi: दूसरी ओर, मीरा मोहित तो थी रोहन के विचारों से, परंतु उसे खुद दुनिया को जानना और समझना भी पसंद था।En: On the other hand, मीरा was indeed fascinated by रोहन's ideas, but she also loved to explore and understand the world on her own.Hi: संस्कृति और प्रकृति, दोनों में ही उसकी गहरी रुचि थी।En: She had a deep interest in both culture and nature.Hi: उनके मार्ग में कई बाधाएँ थीं।En: There were many obstacles in their path.Hi: गर्म और आर्द्र हवा ने उनका मार्ग मुश्किल बना दिया था, और रास्ते के मोड़ भी कोई कम नहीं थे।En: The hot and humid air made their journey difficult, and the twists and turns of the road were also not easy.Hi: रोहन ने एक निर्जन रास्ता चुना।En: रोहन chose a deserted path.Hi: यह रास्ता लंबा था लेकिन संभावना थी कि यहां से उन्हें हाथियों का झुंड मिल जाए।En: This route was longer, but it was likely they would find an elephant herd here.Hi: मीरा थोड़ी चिंतित थी।En: मीरा was a bit worried.Hi: उसने सोचा, "क्या यह सही निर्णय है?En: She thought, "Is this the right decision?Hi: हमारी सुरक्षा भी देखने होगी।En: We also have to consider our safety."Hi: "जैसे-जैसे वे आगे बढ़े, जंगल गहरा होता गया।En: As they moved forward, the forest became denser.Hi: पक्षियों की चहचहाहट और पेड़ों की सरसराहट ने माहौल को जीवंत कर दिया।En: The chirping of birds and the rustling of trees made the atmosphere lively.Hi: पानी की गंध से पता चला कि वे जलाशय के करीब थे, और यहीं उन्हें हाथियों की खोज करनी थी।En: The smell of water indicated they were close to a reservoir, and it was here they needed to look for the elephants.Hi: अचानक, रोहन ने देखा—हाथियों का एक भव्य झुंड नदी में स्नान कर रहा था।En: Suddenly, रोहन saw—a magnificent herd of elephants was bathing in the river.Hi: यह दृश्य अविस्मरणीय था।En: It was an unforgettable sight.Hi: लेकिन एक अच्छी तस्वीर लेने के लिए, उन्हें हाथियों को बिना परेशान किए सही दृष्टिकोण ढूंढना था।En: But to take a good picture, they needed to find the right perspective without disturbing the elephants.Hi: रोहन और मीरा ने बड़ी सावधानी से अपनी साइकिले छिपाई और धीरे-धीरे ऐसे स्थान पर पहुँचे जहाँ से रोहन को सही दृश्य मिल सके।En: With great caution, रोहन and मीरा hid their bicycles and slowly reached a spot from where रोहन could get the perfect view.Hi: कुछ ही पलों में फोटो खींचा गया।En: In just a few moments, the photo was taken.Hi: यह एक शानदार तस्वीर थी—हाथियों का झुंड, पानी के छींटे, और पीछे की हरियाली।En: It was a spectacular picture—a herd of elephants, splashes of water, and the greenery in the background.Hi: रोहन की खुशी का ठिकाना न था।En: रोहन's joy knew no bounds.Hi: उसने उस पल को कैमरे में नहीं, बल्कि अपने दिल में भी कैद कर लिया था।En: He captured the moment not only in his camera but also in his heart.Hi: मीरा, थोड़ी थकी जरूर थी, लेकिन वह समझ गई कि रोहन की इस चाहत में उसकी भी जगह थी।En: मीरा, though a bit tired, realized that she had a place in रोहन's passion.Hi: यात्रा के अंत में, रोहन ने मीरा की ओर देखा और हल्की हंसी के साथ कहा, "तुम्हारे बगैर यह संभव नहीं था।En: At the end of the journey, रोहन looked at मीरा and said with a gentle laugh, "This wouldn't have been possible without you."Hi: " मीरा मुस्कराई और बोली, "और तुम्हारे जुनून ने मुझे ये खूबसूरती दिखाई।En: मीरा smiled and replied, "And your passion showed me this beauty."Hi: " काज़ीरंगा की उस यात्रा ने दोनों को कुछ नया सिखाया।En: That trip to काज़ीरंगा taught them something new.Hi: रोहन ने मीरा की अहमियत को पहचाना, और मीरा ने जीवों और प्रकृति की अद्भुत दुनिया में एक नई समझ पाई।En: रोहन recognized मीरा's importance, and मीरा gained a new understanding of the amazing world of creatures and nature.Hi: दो दिल, एक सपना, और काज़ीरंगा के बीच बनी उनकी अनोखी कहानी।En: Two hearts, one dream, and their unique story amidst काज़ीरंगा. Vocabulary Words:greenery: हरियालीpedaling: चलातेenthusiasm: उत्साहwitness: देखनाconservation: संरक्षणobstacles: बाधाएँhumid: आर्द्रdeserted: निर्जनreservoir: जलाशयmagnificent: भव्यunforgettable: अविस्मरणीयperspective: दृष्टिकोणcaution: सावधानीspectacular: शानदारjourney: यात्राcreatures: जीवोंpassion: जुनूनimportance: अहमियतfascinated: मोहितexplore: जाननाculture: संस्कृतिsurvival: सुरक्षाdense: गहराchirping: चहचहाहटrustling: सरसराहटindicated: पता चलाsplashes: छींटेlively: जीवंतhorizon: दृश्यbicycles: साइकिले

Paris introduces Damaris Galdames-Hough, also known as Dee, who shares her personal journey living with bipolar and how fitness has played a crucial role in her mental and physical well-being. From growing up with a mother diagnosed with schizophrenia to her own experiences with bipolar, Dee opens up about the challenges and breakthroughs she's encountered. She discusses the transformative power of cycling and other fitness routines that not only helped her manage her symptoms but also led to positive changes in her treatment. Additionally, Dee speaks about founding her own cycling studio and her current roles in the fitness community, emphasizing the importance of finding a supportive environment. This episode highlights the significant impact of lifestyle changes and the need for persistence in managing bipolar.Stay connected with Dee right here & if you haven't already please leave a rating/review for the show! :)00:00 Welcome to Live Well Bipolar00:13 Introducing Damaris Huff00:59 Early Experiences with Mental Health02:57 Receiving the Bipolar Diagnosis05:53 Lifestyle Changes and Challenges07:42 Discovering Fitness11:57 The Impact of Cycling16:42 Teaching and Community Building22:48 Fitness as a Mental Health Tool29:13 Final Thoughts and Encouragement

Hour 4: Ken "soft-pedaling" Jed Wills? + Zack Meisel + Francona slow starts full 2156 Wed, 04 Jun 2025 14:15:10 +0000 fDF3rlyS08y1F6AcuGvu5cVu1eryPdv1 sports The Ken Carman Show with Anthony Lima sports Hour 4: Ken "soft-pedaling" Jed Wills? + Zack Meisel + Francona slow starts The only place to talk about the Cleveland sports scene is with Ken Carman and Anthony Lima. The two guide listeners through the ups and downs of being a fan of the Browns, Cavaliers, Guardians and Ohio State Buckeyes in Northeast Ohio. They'll help you stay informed with breaking news, game coverage, and interviews with top personalities.Catch The Ken Carman Show with Anthony Lima live Monday through Friday (6 a.m. - 10 a.m ET) on 92.3 The Fan, the exclusive audio home of the Browns, or on the Audacy app. For more, follow the show on X @KenCarmanShow. 2024 © 2021 Audacy, Inc. Sports False https://player.am

What does this Browns' season stand for? + Was Ken "soft-pedaling" Jedrick Wills? full 740 Wed, 04 Jun 2025 13:22:13 +0000 UdGSv16oTnq90k1qPsj02bHsVlbmd7JC nfl,cleveland browns,sports The Ken Carman Show with Anthony Lima nfl,cleveland browns,sports What does this Browns' season stand for? + Was Ken "soft-pedaling" Jedrick Wills? The only place to talk about the Cleveland sports scene is with Ken Carman and Anthony Lima. The two guide listeners through the ups and downs of being a fan of the Browns, Cavaliers, Guardians and Ohio State Buckeyes in Northeast Ohio. They'll help you stay informed with breaking news, game coverage, and interviews with top personalities.Catch The Ken Carman Show with Anthony Lima live Monday through Friday (6 a.m. - 10 a.m ET) on 92.3 The Fan, the exclusive audio home of the Browns, or on the Audacy app. For more, follow the show on X @KenCarmanShow. 2024 © 2021 Audacy, Inc. Sports False https://pla

 Walking, bicycling and other forms of person-powered active transportation are great for recreation, getting from point A to point B and improving one's health and wellness. Episode 52 explores state- and community-based efforts to keep Oklahomans moving in fun and safe environments. Guests are ODOT Active Transportation Coordinator Bart Vleugels and TSET Healthy Living Program coordinators Shelby Keller of Payne County and Stephanie Pendergraft and Kate Ladwig of Garfield County, who discuss Walk This May events in Stillwater and Enid.

Andrew Walworth, Tom Bevan and Carl Cannon discuss the reactions from Donald Trump and Hakeem Jeffries to the announcement this weekend that former President Joe Biden has been diagnosed with prostate cancer. Also, Rep. LaMonica McIver (D.-NJ) is charged with felony assault against a federal officer during a protest earlier this month at and ICE detention center. Then, they discuss the Supreme Court's 8-1 decision to allow the Trump Administration to remove temporary protective status for 350,000 Venezuelan migrants, and former FBI director James Comey telling MSNBC how he found a shell formation spelling out “8647” on a beach walk with his wife. Plus, they talk about the resignation of CBS News president Wendy McMahon, who is leaving because she “could not agree on the path forward with management” regarding Paramount's apparent plans to settle a lawsuit with President Trump over the editing of a television interview with Kamala Harris. Then lastly, former U.S. Ambassador the United Nations and Trump National Security Advisor John Bolton talks to RCP Contributor Charlie Stone about Trump's approach to the Middle East and what it's like to advise Trump on foreign policy matters.

What does it take to build a biking partnership that spans decades and thousands of miles? Ken Francis and Phillip Robinson share how a chance online meeting led to unforgettable adventures across the US, Europe, and beyond—from self-supported rides in the Pacific Northwest to creative hybrid trips combining trains, roller coasters, and open-road cycling.Through the highs of thrilling coasters and vibrant cities to the lows of headwinds and flat tires, their story highlights the power of adaptability, mutual support, and a shared passion for exploration. Whether wild camping in the desert or reconnecting with Warmshowers hosts, their journey reveals the resilience and joy found in lasting friendship on two wheels.You can follow Ken on YouTube at Ken Francis World and The Intimacy Gram. Find him on Instagram @KenFrancisOnTour and @The_Intimacy_Gram. Catch up with Phillip on Facebook.Join our community at Warmshowers.org, follow us on Instagram @Warmshowers_org, and visit us on Facebook. You can also contact Tahverlee directly at Tahverlee@Warmshowers.org.Special thanks to our sponsor, Bikeflights – the best in bicycle shipping service and boxes, guaranteed.Theme Music by Les Konley | Produced by Les KonleyHappy riding and hosting!

This warmer weather is the perfect time to dust off the bike and hit the road for a good cause. Bike MS is holding its annual "Cape Cod Getaway" next month to raise money for the National MS Society, which works each and every day to find a cure for multiple sclerosis. The Getaway is a two-day affair, and you won't even have to rent a vacation house! Jennifer Dowdy, the Development Director of Bike MS, and Liam Kennedy, captain of Liam's Lucky Charms, join Nichole to talk about it.

The Hidden Lightness with Jimmy Hinton – One of the most inspiring aspects of Working Bikes' global partnerships is the impact on women. In countries where economic opportunities for women are limited, these bicycles are enabling them to create businesses, whether it's transporting goods, offering taxi services, or launching delivery ventures. With reliable transportation, women are better...

Mike goes for a rare bike fit and we dive deep into the nuances of a comfort, position, aero power, and training strategy. We look at saddle height and position. Aero bars. Drop, reach, contact points. We also talk cleats, hip room and running niggles that may be caused by the bike. We look at the gains you can make in aero, talk about why comfort is king, and the keeys to speed. We also talk about some of the simplest and best ways to train.  Topics:  Saddle height and position Aero bars and where yours should be Contact points for bike fits Cleat position Sore necks The power advantages of being aero Arm fatigue and how it creates a perceptive fatigue on the run Finding solid aero is a process Volume vs. Intensity in training Keys to speed Brands and different features Bike fit bikes Comfort is king Pedaling to pedal Pedaling with pressure Pedaling with purpose Mike Tarrolly - mike@c26triathlon.com Robbie Bruce - robbie@c26triathlon.com

Experience the thrill of European cycling as we recount our 2025 Spring Classics camp journey, where two-wheeled adventures met the charm of Belgian squares and French angles. Find out how Josh's playful antics and Ralph's van mishap added laughter to an already memorable trip that began and ended at Heathrow. Learn the secrets behind tackling iconic sportives like Flanders and Roubaix, savoring Belgian beer, and the camaraderie that binds cyclists as they conquer famous climbs and navigate the cobblestone chaos. Will you uncover the strategies that keep cyclists in high spirits despite relentless winds and challenging gravel paths? Get a front-row seat to the thrilling races in Ehrenberg, feeling the pulse of the velodrome as a French Olympic champion makes a triumphant return. Share the tension of Mads Pedersen's flat tire and Vanderpool's dramatic lead, with each turn of the wheel echoing the raw energy of European cycling. From the picturesque roads to the vibrant cycling community, this episode captures the essence of what makes cycling in Europe an unforgettable experience. As we bid adieu to the classics, anticipation grows for future adventures, with Tuscany's training camp on the horizon. Join us, Coach Patrick and the team, for a journey that goes beyond the ride, embracing the spirit and stories of the cycling world.

How does one overcome polio and diabetes to embark on an incredible cycling journey?In this inspiring episode, Ken Reinke shares how he pedaled across the country multiple times after turning sixty. In fact, Ken has ridden over 9,000 miles since his 67th birthday! From Florida to San Diego and beyond, he embraced freedom on the road while carefully managing his health.With stories of stealth camping, kindness, and discoveries along the way, Ken's journey embodies resilience and adventure. Gain insight into the mental and physical challenges of long-distance cycling and the importance of enjoying the ride.A must-listen for anyone dreaming of their own cycling adventure!Get Ken's book, The Road Spoke: Trepidation and Tranquility on a Bicycle Odyssey, on Amazon or Goodreads.Join our community at Warmshowers.org, follow us on Instagram @Warmshowers_org, and visit us on Facebook. You can also contact Tahverlee directly at Tahverlee@Warmshowers.org.Theme Music by Les Konley | Produced by Les KonleyHappy riding and hosting!

Chris Cornwell of Northern Neck Bike Club, is proving that a love for two wheels can spark something bigger. What started as a passion for mountain biking turned into a mission to create outdoor opportunities for the youth of Kilmarnock, Virginia. With the town's support and a dedicated team, Chris helped establish a nonprofit that promotes cycling, mentorship, and trail development.In this episode, Chris shares how the club quickly grew from a simple idea into a full-fledged movement—offering race training, community ride days, and even access to bikes for kids in need. He also dives into the importance of staying active, the value of persistence in making a dream a reality, and the future of trail building in their growing community.Whether you're a cycling enthusiast or looking for inspiration to start something meaningful in your own town, this episode is for you!Life in Motion is brought to you by Actual Outdoors. They help build beautiful brands that highlight the approachable and authentic parts of outdoor recreation. Said simply - they “keep it real”. Find them online at actualoutdoors.com or on Instagram at @actualoutdoors.Tweet us and let us know what you think of this episode! @illuminecollectFind more episodes at www.illuminecollect.com/blogs/life-in-motion-podcastSince 2017 Illumine has donated over $46,258 to outdoor nonprofits and shared over 234 stories on the Life in Motion Podcast.

For the seventy-third episode of the It's Just A Hill Cycling Podcast, Jon and BSP sit down for a catch-up at the top of the show, diving into Jon's thoughts on riding in northern Rhode Island since moving. The conversation shifts into helmet talk—what they currently use, how often they replace them, and whether they actuallyContinue reading "Helmet Chat, Creatine, and Pedaling for Progress | IJAH Pod 073"

Pastor Joe shared from Psalm 23 on the theme of the importance of daily worship in finding courage in God.

Pastor Joe shared from Psalm 23 on the theme of the importance of daily worship in finding courage in God.

What if launching e-commerce for an established retail brand isn't just about going digital, but about fundamentally transforming your business culture?Join hosts Chuck Moxley and Nick Paladino as they talk with Nora Arzoumanian, Former E-commerce and Digital Marketing Director at Specialized Bicycle Components. Drawing from her experience launching Specialized's Canadian e-commerce platform during post-pandemic inventory challenges, Nora shares invaluable insights on building an online presence while balancing brick-and-mortar relationships, managing inventory allocation, and evolving influencer marketing strategies.In This Episode:When launching e-commerce in an established retail business, focus on long-term commitment and educate internal stakeholders with data to overcome resistance to change.Start influencer marketing with quality over quantity - work with fewer, highly engaged partners who truly understand your brand rather than casting a wide net.For luxury brands, maintain brand value by focusing on your core market rather than trying to serve every price point and customer segment.Want more tips and strategies to create frictionless user experiences? Subscribe to our newsletter!https://www.thefrictionlessexperience.com/frictionless -Specialized Bicycle Components Website: https://www.specialized.com Nora's LinkedIn: https://www.linkedin.com/in/noraarzoumanian/ Chuck's LinkedIn: https://www.linkedin.com/in/chuckmoxley/ Nick's LinkedIn: https://www.linkedin.com/in/npaladino/Chapters:(00:00) Introduction(01:10) Launching E-commerce Post-Pandemic (04:50) Canadian E-commerce Challenges(08:25) First Steps in Building E-commerce(10:50) Bike Purchase Process(12:55) Canadian Market Localization(14:35) Managing Inventory Challenges(17:05) Omnichannel Experience Development(21:55) Understanding Customer Education(24:05) Brand Strategy and Market Focus(27:35) Influencer Marketing Evolution(33:30) Internal Friction in Digital Transformation(37:12) Episode Recap

In this episode of The 10Adventures Podcast, we sit down with Jacob Lemanski, who shares the story of his awe-inspiring 999-day journey cycling 38,000 miles across six continents—twice! What started as a personal challenge to discover his limits turned into an epic adventure of resilience, exploration, and connection with people worldwide.   Jacob recounts his route, from Portugal through Europe and Asia, to the Arctic Circle, all the way to the southern tip of South America, and even across Africa, New Zealand, and Australia. He talks about life on the road, camping in remote places, and the unexpected kindness of strangers. We also dive into the mental and physical challenges of such an ambitious goal and how the journey shaped his perspective on life, adventure, and human connection.   Check out Jacob's website: https://www.howtomovethestars.com/ Follow him on Instagram: https://www.instagram.com/howtomovestars/ Link to his Podcast: https://www.youtube.com/@HowToMoveTheStars/videos   About Us

Send us a textIn this episode, we're thrilled to welcome Amanda Carey, President of the National Interscholastic Cycling Association (NICA), to explore the powerful ways NICA and local bike retailers can work together to inspire and support the next generation of cyclists.NICA's programs are bringing thousands of youth into the sport, and this conversation will give bike shop owners a deeper understanding of how they can join this movement to grow ridership, drive in-store traffic, and build loyal relationships with young riders and their families.Support the show

In this week's episode of Taiwan Talk, ICRT's Tim Berge sits down with YouBike spokesperson Vicky Yang to discuss the evolution of Taiwan's popular bike-sharing system. -- Hosting provided by SoundOn

In this compelling episode of Healthy Waves, host Avik Chakraborty dives into the profound connections between mental, emotional, and physical health with two extraordinary guests: Melissa Crook and Emmanuel Rose. Together, they explore how personal challenges can inspire transformative journeys and how solitude, nature, and storytelling can foster resilience. Melissa shares her life-altering experience at 50 that led her to advocate for women's self-care, while Emmanuel discusses the role of nature and solitude in unlocking creativity and achieving professional success.   About the Guests: Melissa Crook: A passionate advocate for women's emotional and physical health, Melissa is the host of the Fiory Podcast, where she creates a supportive space for women to heal and grow. Her journey began after a personal health crisis at 50, leading her to champion the importance of self-care, emotional wellness, and boundary setting for women. Emmanuel Rose: A seasoned marketing innovator, author, and passionate storyteller. With over 30 years of experience, Emmanuel has learned to balance his professional life with his love for nature, using it as a source of inspiration for his creativity and resilience. Key Takeaways: Self-Care as a Priority: Melissa emphasizes the importance of processing emotions, setting boundaries, and prioritizing personal well-being to prevent physical and emotional burnout. The Role of Nature in Mental Health: Emmanuel highlights how immersing oneself in nature and embracing solitude can unlock creativity, foster mental clarity, and build emotional resilience. Intersection of Health Dimensions: Mental, emotional, and physical health are interconnected; neglecting one can adversely impact the others. Resilience and Success: Both guests underline the importance of resilience, whether through emotional healing or finding balance in life, as a cornerstone of personal and professional success. One Key Learning: Healing begins with acknowledging and processing your emotions—when you take time to nurture your mental and emotional well-being, your physical health and professional success follow suit.   Want to be a guest on Healthy Mind, Healthy Life? DM on PM - Send me a message on PodMatch, •⁠  ⁠DM Me Here: https://www.podmatch.com/hostdetailpreview/avik  •⁠  ⁠Subscribe To Newsletter: https://healthymindbyavik.substack.com/ •⁠  ⁠Join Community: https://nas.io/healthymind Stay Tuned And Follow Us! •⁠  ⁠YouTube - https://www.youtube.com/@healthymind-healthylife •⁠  ⁠Instagram - https://www.instagram.com/podhealth.club/  •⁠  ⁠Threads - https://www.threads.net/@podhealth.club •⁠  ⁠Facebook - https://www.facebook.com/podcast.healthymind •⁠  ⁠LinkedIn - https://www.linkedin.com/in/newandnew/ #podmatch #healthymind #healthymindbyavik #wellness

“We're creating a whole new market of active mobility.”In this episode of Third Angle, we're taking a trip to the French Alps to learn all about the future of one of the newest forms of transport - a visionary, chainless vehicle with an advanced pedaling system. Carlos Torres, Co-Founder and Head of Design at CIXI, Nicolas Ohlmann, Co-Founder and Chief Technical Officer and Fabien Ronzani, Engineer show us how the team is redefining active mobility and creating a new world where they want everyone to be physically active. They're doing this through the use of their pedaling system, PERS and their exciting creation, Vigoz. Listen to explore how CIXI integrates innovation into every detail - from the workshop's “theatrical” assembly process to the high-powered Vigoz, which amplifies human energy enabling riders to reach up to 120 km/h. Find out more about CIXI here. Find out more about OnShape here.Your host is Paul Haimes from industrial software company PTC. Episodes are released bi-weekly. Follow us on LinkedIn and X for updates.This is an 18Sixty production for PTC. Executive producer is Jacqui Cook. Sound design and editing by Rema Mukena. Location recording by Ashley Clivery. And music by Rowan Bishop.

So much of our lives are spent in a car. Whether it's driving to work, scooting around kids to friends houses and other activities, or running to the post office, we really are stuck in a car-centric culture. But today's guest is trying to get us out of that rut, one bicycle at a time.Donna Matturro McAleer is the Executive Director of Bicycle Collective, a group of non-profit bike shops refurbishing donated bicycles and putting them into the hands of those in need, focusing on children, Newly resettled refugees, immigrants, individuals experiencing homelessness or housing insecurity and more.In this episode, they explore the broader economic, environmental, and community impacts of making bicycles accessible as a form of sustainable transportation. We'll also hear about the Bicycle Collective's programs, sustainable business model, and pandemic growth.Eccles Business Buzz is a production of the David Eccles School of Business and is produced by University FM.Show Links:Donna Matturro McAleer | LinkedInDonna Matturro McAleer | 2024 CEO of the Year - Utah BusinessBicycle CollectiveDavid Eccles School of Business (@ubusiness) • InstagramEccles Alumni Network (@ecclesalumni) • Instagram Episode Quotes:In a car-centric country where transportation poses significant barriers to economic stability, bicycles emerge as a transformative tool. [03:32] If you think about it, Frances, In Utah, in our country, we are a car-centric country. But if you think about transportation, transportation is a formidable barrier to economic mobility. Access to nearly everything associated with economic progress and upward mobility, whether that's getting to school, getting to a job, getting to a job interview, fairly priced goods and services, medical services, healthcare, depends on the ability to get from one place to another efficiently and in an affordable manner. And that's where a bike can really be a transformative tool, especially in a place like Salt Lake City and throughout this state where so many resources may be concentrated within a few miles.Choosing a bike over a car can cut your carbon footprint by 67% and transform communities[08:22] Choosing a bike over a car just once a day reduces the average person's carbon footprint from transportation admissions by 67%. So, that's just once a day. Think about if you use it as your primary form of transportation, a moderate increase in bicycling each year could save 6 to 14 million tons of carbon dioxide. So, there's huge, huge impacts that bicycling has on the individual, on the community, on the economy, and on the environment, all in a positive way. It's not a trade off of one or another. We get to experience all those things with biking.Bicycle Collective is a resource for everyone[20:16] Bicycle Collective is really for everyone. Whether you are a first-time cyclist or maybe you want to try a new discipline, but you want to get in at an affordable level. So, maybe you never tried mountain biking and you want to get a mountain bike or you want to start road riding or, hey, I've been road riding, I've been mountain biking, but I want to be a bike commuter. We are a great resource for cycling enthusiasts, first-timers.

What happens when life throws you a curveball and you find yourself on an entirely new path? Meet Zach, an inspiring cyclist and military veteran, as he shares his compelling story of resilience and transformation. From his early days growing up in the Yukon area and joining the Marines, Zach's journey is marked by moments of challenge and triumph. His tale takes us from the rigorous demands of military service to the exhilarating world of competitive track cycling.Join us as we explore the profound impact of a life-altering cycling accident that tested Zach's physical and mental limits. Miraculously recovering from severe injuries, he found new purpose and ambition in cycling, a passion reignited through support from Paralympic programs and VA initiatives. With candid insights into the technical and emotional aspects of rehabilitation, Zach reveals how cycling became a beacon of hope and a catalyst for his Paralympic aspirations.This episode also celebrates the unique world of track cycling, highlighting the thrilling races, innovative technologies, and the camaraderie at events like the Endeavor Games. Discover the vibrant stories of community, competition, and connection that make cycling a unifying force. Zach's experiences, intertwined with a couple's journey into foster care and adoption, offer a rich tapestry of inspiration, encouraging us all to embrace our athletic dreams and engage with the cycling community.Instagram @zachthemarinebarber

ANTIPHONAll my cares I place in Your hands.SCRIPTUREPsalm 12Proverbs 8:17REFLECTIONSister CarolMUSICSet the Course (Instrumental)Esenvalds - Stars by VOCES8NOTES

Two-time Emmy and three-time NAACP Image Award-winning, television Executive Producer Rushion McDonald, interviewed Karon Joseph Riley. He co-stars in the popular The Black Hamptons series on BET+. His book navigates life's ups and downs and uncovers the importance of perseverance, resilience, and determination. It shares his insightful reflections entitled "Keep Pedaling: Things I Learned On My Bike."   Whether facing steep inclines or unexpected detours, he learns to embrace challenges as opportunities for growth and transformation. Through encounters with nature, encounters with others, and moments of solitude, he discovers the power of mindfulness and living in the present moment. "Keep Pedaling" is more than a self-help book; it's a roadmap for navigating life's twists and turns with grace and courage. Through Karon's heartfelt lessons and candid reflections, readers will find inspiration to overcome obstacles, pursue their passions, and savor the beauty of the journey itself. "Keep Pedaling" is a reminder that no matter where life takes you, as long as you keep moving forward, the possibilities are endless. Full-scale production company that has the capacity to take a film or television project from creation to distribution and all the production necessary in between #STRAW #SHMSSupport the show: https://www.steveharveyfm.com/See omnystudio.com/listener for privacy information.

Two-time Emmy and three-time NAACP Image Award-winning, television Executive Producer Rushion McDonald, interviewed Karon Joseph Riley. He co-stars in the popular The Black Hamptons series on BET+. His book navigates life's ups and downs and uncovers the importance of perseverance, resilience, and determination. It shares his insightful reflections entitled "Keep Pedaling: Things I Learned On My Bike."   Whether facing steep inclines or unexpected detours, he learns to embrace challenges as opportunities for growth and transformation. Through encounters with nature, encounters with others, and moments of solitude, he discovers the power of mindfulness and living in the present moment. "Keep Pedaling" is more than a self-help book; it's a roadmap for navigating life's twists and turns with grace and courage. Through Karon's heartfelt lessons and candid reflections, readers will find inspiration to overcome obstacles, pursue their passions, and savor the beauty of the journey itself. "Keep Pedaling" is a reminder that no matter where life takes you, as long as you keep moving forward, the possibilities are endless. Full-scale production company that has the capacity to take a film or television project from creation to distribution and all the production necessary in between #STRAW #SHMSSee omnystudio.com/listener for privacy information.

Hello again, everyone. Welcome to episode 449 of the Outdoor Biz Podcast. This week, I'm talking with Lauren Hefferon. Lauren has been a devoted cyclist for over 40 years. While in high school in Southern NH, Lauren discovered her passion for pedaling after a serious ski injury prevented her from downhill ski racing and playing many team sports. Upon graduation with a degree in Graphic Design in Mass Art, Laure decided to follow her entrepreneurial cravings and launched Ciclismo Classico. Their mission is to inspire active travelers to embrace cycling as a soulful form of travel that connects us with the world and to the passionate, curious, and creative human spirit. Facebook​ ​Twitter​ ​Instagram​ Love the show? Subscribe, ​rate, review, and share!​ Sign up for my Newsletter ​HERE​ I'd love to hear your feedback about the show! You can contact me here: ​rick@theoutdoorbizpodcast.com Brought to you this week by Thrive Market Show Notes 00:00 Rick Saez shares outdoor industry insights, interviews, and product innovation on the Outdoor Biz Podcast. 03:30 Lauren grew up without a bicycle in 1950s, until she goe her green Schwinn. 06:34 Art and curiosity drives Lauren's varied interest in anthropology. 11:21 After Cornell, Lauren toured Europe, worked as a tour guide in Italy. 13:30 Created educational bike tours, focused on teaching, not luxury. Started with Pisa to Florence itinerary. 17:21 Some of the earlychallenges were in bike quality and hotel operations. 20:59 Lauren believe in learning through bicycle tours. 24:25 Promotion of lesser-known trips in Italy, creates a succession of tours. 27:57 The goal is to create memorable and safe experiences on bicycle trips, including organizing a surprise performance by the Cortina Choir in the Dolomites. 31:20 Switching from driving tours to biking trips, aiming for full human-powered travel, with exceptions for uninteresting or traffic-heavy stretches. 32:53 Gravel riding in Tuscany and other regions is popular. 35:25 Prefer phone calls for personal connection in planning bicycle trips. Focus on understanding and personalizing experience. 40:44 I love Mary Oliver's nature poems, they remind me to be grateful. 42:01 Cycling should be enjoyed at your own pace, not about speed or sleekness, akin to a ski vacation. 45:37 E-bikes are extending cycling age range and accessibility. 49:32 Lauren turned cyclist after a knee injury, emphasizing the importance of low-impact exercise. 51:13 Thanks for tuning in to the Outdoor Biz Podcast. Visit our website for show notes and subscribe to never miss an episode. Spread the word and leave a rating on Apple Podcasts. Learn More You can follow up with Lauren on Facebook and Instagram by email: and call her directly at: 617-640-4837. That's my cell phone. And then our 800 number is 1-800-866-7314. And our company is www.cyclismoclassico.com Next Steps If you enjoy interviews devoted to the outdoor industry, find us online at ricksaez.com/listen. We love likes and comments, and if you know someone who is also an outdoor enthusiast, go ahead and share our site with them, too. And be sure to Subscribe to our newsletter Keywords #Ciclismo Classico, #bike touring, #educational tours, #Italy, #guided tours, #safety clinics, #immersive experience, #cultural interaction, #ebikes, #adventure travel, #personalized experiences, #electric bikes, #environmental benefits, #eco-friendly practices, #gravel riding, #Piedmont, #Tuscany, #Sicily. Podcast produced using Descript, CastMagic Podcast hosted by Libsyn: sign up with code 'outdoorbizpod' for 20% OFF Show Notes powered by Castmagic Website powered by Wordpress Get Your Podcast Published NOW!  I'm partnering with Tracy DeForge, Stephanie Euler, and the Produce Your Podcast team to get it out of your head and into your followers ears. Tracy and her team have helped me grow and monetize my show, and podcasters trust them because they deliver. Go to https://ricksaez.com/pyp to get all the details. Let's get your show created, produced, and on the air today. Go to https://ricksaez.com/pyp and get all the details. Let me know if you have any questions.   Note: As an Affiliate of Amazon and others, I earn from qualifying purchases.

"We are all humans here just trying to do God's work. And my dad says, that's the role of a father."             Today's guest is doing just that. He's a fatherhood activist, businessman, friend, and dad of five. Join us as David Hirsch shares his inspiring journey of advocating for father involvement, raising awareness about the impact of father absence, and the importance of meeting children where they are.             David reflects on his own experiences, from being raised by a single mom and his grandfather's significant influence, to his commitment to being a present and involved father. He discusses the importance of evaluating each situation on a case-by-case basis and the unique challenges faced by single mothers and fathers raising children with special needs.     We discuss the Special Fathers Network and the remarkable stories of dads who have gone above and beyond for their children. David also shares his transformative experience of biking across the country to raise awareness for father involvement and the lessons learned along the way.     Whether you're a parent, an advocate, or someone interested in the dynamics of fatherhood, this episode is filled with heartfelt reflections, practical advice, and a celebration of the vital role fathers play in their children's lives.       Better Call Daddy: The Safe Space for Controversy.       Connect with David Hirsch:        - Website: 21stcenturydads.org Linkedin: https://www.linkedin.com/in/davidhirschsvp/   Connect with Reena:        - Website: bettercalldaddy.com - LinkedIn: linkedin.com/in/reenafriedmanwatts - Twitter: @reenareena - Instagram: @reenafriedmanwatts - Instagram Podcast: @bettercalldaddypodcast         We love hearing your feedback. Leave us a review, share your thoughts, and spread the word about this enriching episode. Share it with someone who appreciates the wisdom of fatherhood and the importance of parental involvement.     (00:00) Reena Friedman Watts hosts the better call daddy show each week (01:55) Reena Friedman: 23 million young people in the country experience father absence (09:41) When you're raising kids, you think looking forward when they're young (13:23) The Illinois Father initiative asks youth what their father means to them (18:17) John St. Augustine says dysfunctional relationship with father shaped his life (23:36) Were you ever able to see your dad as human? Were you able to tell him anything that was right (26:36) John Augustine took a 21 day bicycle ride across America in 2015 (32:46) Reena says cycling is challenging but relatively easy compared to parenting (36:22) Family size is directly proportional to the number of children the woman wants to have (48:22) Sam Solomon interviews father of three daughters on special fathers network podcast (54:19) David Hirsch says it's important for fathers to be involved in children's lives Remember, it's not just about the stories we share, but the wisdom we gain and the connections we nurture along the way. Tune in and get ready to explore the world through David Hirsch's eyes.     Show notes created by https://headliner.app  

Jon gives it up for NC State. David remembers the Bad Lieutenant. Join EPM Madness!! http://bit.ly/epmmadness Support us on Patreon at http://patreon.com/electionprofitmakers Send your election prediction questions to contact@electionprofitmakers.com Watch David's show DICKTOWN on Hulu http://bit.ly/dicktown