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I get bombarded again and again with wonder supplements, methods… And most are not tested in the long term or even have any reliability…For instance NAC & Glutathione…The great antioxidant?And today we know we need also Oxidants… We should balance both Antioxidants and Oxidants...And the researches on NAC and Glutathione are not sufficient or even totally insufficient in the short and long term…The Fish oil and Omega Alpha Oil supplements can't be digested!Eat 3 spoonfuls of flaxseed to get enough Omega Alpha Oil for the brain…Then this stupidness to recommend Olive virgin oil...Every unsaturated fatty acid, which is mainly Olive Oil will be transformed in our body into the most dangerous Aldehyde, and even worse more than 80g of any oil or fat will increase our chances of dementia 5 times…Or this American Billionaire with his colored hair and unhealthy looking is selling his longevity drug, that he had created out of 100 different medicaments… The Nobel prize winner for creating the formula of Viagra that kills so many men!We should do vigorous exercise, what does not kill us but makes us stronger when we age? What happens if we continuously do our exercises on the treadmill or swim… when we age… Looks much smarter. And even we don't risk to die!My hair is still dark brown and full at the age of 65 years… And I am totally fit, healthy and hard to beat in the sport… Maybe I am wrong, not to take so many drugs!I take Creatine, Taurine, Maca, Tongkat Ali, Jio GU LAN, and Panax Ginseng, When I go to bed, I take Magnesium, which prevents heart attack and heart arrest when sleeping. This food, I take to get the Minerals for my body.3 Brazil nuts, selenium for stronger immune system50g Wake me dried Seaweed10g Moringa20g dark cocoa powder10g bamboo leaves, tea, for silica to build stronger bones.3 Times/day probiotics as fermented vegetables, fruits, and Coconut yogurt.Fermented soy beans - Natto for bones, autophagy, and longevity.I eat only raw food, no meat… I do interval training on the treadmill for the cardiovascular system…And other workouts. During my workouts, I do the ice bath-plunge for 2 minutes to feel good. 4 times/week infrared sauna blanket with icebath-plunge awesome for the cardiovascular system and to feel good… If you research all these so-called alternative doctors for teeth health…They are so damn wrong… There is only one scientific formula with Xylitol and Sodium Fluoride that builds up a healthy mouth bio-top and kills all plaque bacteria and other unhealthy bacteria in our mouth. Even it rebuilds the tooth so you get rid of cavities without doing a filling! Read my blog: Xylitol for healthy teethMy Video: The unreliability of Western Medicine for longevity https://youtu.be/C0UDGclIPzYMy Audio: https://divinesuccess.net/wp-content/uploads/2021/Podcast4/The-unreliability-of-Western-Medicine-for-longevity.mp3
A bumper episode this week, starting with a deep dive into the new Estée Lauder Legacy x Frederic Malle collection of brilliantly re-imagined classics, there's also a discussion of a limited-edition Serges Lutens that delights Suzy and disturbs Nicola, and an incredible MEMO fragrance that transports you to a gloriously unique landscape in Turkey. And here's something different – we focus on the fascinating question sent in by a listener who's lucky enough to be going to the @taylorswift ERAS tour and wants to know how we'd scent it. So, we went one step further and have matched a fragrance for every major album, reflecting the mood shift and growth process in each perfume choice... Do you agree, or would you have chosen differently? How would YOU scent the tour? Or perhaps there's a musician / film / book / TV Show or some other art form you'd like us to ‘scent match'? Let us know!In This Week's Show: @esteelauderuk @fredericmalle Legacy Collection Azurée Legacy – “A warm and sublime original Estée Lauder fragrance reimagined with notes of Cumin.” (@anneflipoperfumer) Private Collection Legacy – “A reimagined version of the classic scent that allows the floral green notes of the original to shine. Notes of Green Accord, Jasmine and Rose.” (@anneflipoperfumer) White Linen Legacy – “A warm, lush fragrance with the richness of the original scent. Notes of Aldehyde, Rose and Amber.” (@carlos.benaim) Estée Legacy – “An intoxicating floral musk fragrance with notes of Sandalwood, Honey and Jasmine.” (@carlos.benaim) Knowing Legacy – “A rich, fruity scent expanded from the original with notes of Black Currant and Orris.” (@brunojovanovicperfumer) @sergeslutens L'Orpheline (limited edition) @memo.paris CappadociaScent-matching Taylor Swift's ERAS Tour, album by album...Taylor Swift: Nicola chose @dsanddurga Cowboy Grass Fearless: Suzy chose @ninaricci L'air du Temps Speak Now: Nicola chose JHAG Lily Fantasy Red: Suzy chose Dior Hypnotic Poison Reputation: Suzy chose Kilian Good Girl Gone Bad Lover: Nicola chose @ninaricci L'air du Temps Folklore: Suzy chose @penhaligons Luna Evermore: Nicola chose @roosandroos In the Wood for Love Midnights: Suzy chose @electimusslondon Aquila Absolute
Imagine before the 20th century there was rarely any heart attack and no diabetes…With the American invention of that vegetable oil with multiple polyunsaturated fatty acids, heart attack and diabetes increased so dramatically that heart attack and Cardioid arrest is the cause of death number One.Before the people ate the normal animal saturated oils or fat and had only a few problems with the heart or cancer and with diabetes no issue.The same was true for India when the normal food was without any oil or fat… When the Indians started to eat that industrially processed food with vegetable oil… heart attack, cancer, diabetes increased so dramatically.After World War II the Germans were starving and could cover their calories only with animal saturated fat and oil… Again, very few heart attacks, and even very few cancers…In a study over 8 years, a group of people over 60 years old ate only vegetable oil and the other group animal saturated fat… Guess, the group with consuming vegetable oil had far more deadly than the group that consumed only animal saturated fat…,The National Health Association which was founded 300 years ago, recommends only to eat raw food and never eat any oil or fat. Their members had rarely any heart attack, diabetes, Alzheimer or cancer. Today the average American eats 80g of fat or oil every day, and is getting fat and sick with heart diseases, diabetes, Alzheimer and cancer… If we boil/broil vegetable oil, then the polyunsaturated fatty acids and monounsaturated fatty acid oxidate become toxic and produce Aldehydes like acetaldehyde that let us feel terrible. That is true for every vegetable oil, regardless if whether it is cold-pressed oil or the normally processed oil with polyunsaturated fatty acids and monounsaturated fatty acid; heated it up it becomes poison.Every unsaturated fatty acid molecular likes to be saturated and so it is a must to produce Aldehydes to become saturated. Frying in vegetable oil with polyunsaturated fat generates 100 to 200 times more Aldehydes than the daily limit set by the WHO…The industrially processed oil is in any case heated up over 200 Celsius and so poison.The coconut and palm oil are mainly saturated fat and so produce less poison if we boil them...If you consume the cold-pressed Olive oil and don't cook it, the polyunsaturated fatty acids in the olive oil oxidate very fast when exposed to the air and the monounsaturated fatty acid oxidate also, but not so fast by expoed to the air. The animal fat/oil is 100% saturated oil/fat and so cannot produce that poison Aldehyde.But if you eat more than 21g saturated fat/oil you increase your chance of Alzheimer's 3 times. What happens if the vegetable oil is in our bodies?In our body, the vegetable oil oxidates to an Aldehyde called 4-HNE that is the most toxic Aldehyde. And that is associated with aging, heart diseases, diabetes, and Alzheimer's.Even worse, if we accumulate the Aldehyde 4-HNE in our body we dysfunctional the energy support of our body-cells! And so, our body can collapse and die rapidly even we are not aware of it. Our mitochondria in the cells use food calories to create energy in the cells. The accumulation of the Aldehyde 4-HNE in our body reduces the production of mitochondria up to 5 times! And that leads to fatigue and many diseases, like heart diseases, diabetes, obesity, and death. Still, you can eat Avocados, Nuts, and Seeds… and they are healthy if they are not boiled/fried/roasted and if you don't eat too much from them.
Satan's Live Forever Soul Trap - Men shall Seek Death and Not Find it In recent years, the concept of achieving digital immortality, often referred to as the "AI Rapture," has captured the imagination of scientists, technologists, and futurists alike. This bold vision suggests that, one day, humanity may transcend the limitations of our physical bodies and upload our consciousness into the digital realm. In the pursuit of this dream, some innovators are taking unprecedented steps, such as preserving human brains and even reconnecting severed heads to spinal cords using advanced materials like graphene. But how close are we to achieving this grand ambition of living forever, or at least digitally? To embark on the path to digital immortality, one essential step is preserving the human brain with utmost precision. The science of connectomics is central to this endeavor. Connectomics aims to map the neural connections within the brain, creating a comprehensive blueprint of the mind. Recent advances in neuroscience and imaging techniques have enabled scientists to make remarkable progress in understanding the intricate neural networks that underlie consciousness. The Brain Preservation Foundation is an organization at the forefront of brain preservation research, aiming to develop techniques that can store the brain's structure and function in unprecedented detail. Aldehyde-stabilized cryopreservation, for instance, is one method that shows promise for preserving brains at the nanoscale level, potentially enabling the preservation of memories and personal identity. Uploading one's consciousness to a digital format remains a highly speculative area of research. In theory, it would involve capturing the entire state of an individual's brain, including thoughts, memories, and emotions, and transferring this data into a digital substrate. Researchers like Ray Kurzweil, a prominent futurist, have posited that this transfer could enable a form of digital immortality. However, this concept faces formidable challenges, not least of which is our limited understanding of consciousness itself. Another intriguing development in the quest for digital immortality is the application of cutting-edge materials like graphene to reconnect severed heads to spinal cords. This concept is rooted in the idea of repairing spinal cord injuries, which can have devastating consequences for an individual's mobility and quality of life. By using graphene as a conductive material and a bridge for neural signals, some researchers hope to restore lost functions and potentially preserve the connection between the body and the brain. The Promethean dream of reconnecting severed heads and achieving digital immortality, however, remains in the experimental stage and faces numerous ethical and medical considerations. While these developments are undoubtedly exciting, there are formidable challenges to overcome before we can talk about achieving digital immortality. These include: We still lack a complete understanding of consciousness and how it emerges from the brain's complex neural networks. The concept of brain preservation, digital immortality, and body reconnection raises profound ethical dilemmas related to personal identity, consent, and the nature of existence The technology required to upload and preserve consciousness in a digital format is beyond our current capabilities. Many fundamental questions about the brain and consciousness remain unanswered. This is a satanic soul trap trick. Ref Videos: Attack Severed Brains - https://youtu.be/2F-imlUpnI0 Upload your Brain: https://youtu.be/yMOvKBaBf2s Aliens could be digital (deception): https://youtu.be/HOgqM9oCrYc SJWellFire Save Souls with an OfGod Tshirt: https://sjwellfire.com/shop/ Join our newsletter: https://sjwellfire.com/ Gab: https://gab.com/sjwellfire Support us to save souls via the news: https://sjwellfire.com/support/ or scott@sjwellfire.com paypal Prepare: https://sjwellfire.com/partners/
It's our longest episode yet, for better or worse, but things go deep when you start talking about disappointing new releases, the intoxicating and transformative sensations of testing Strangelove NYC all week, and how we benefit from each other's fondness of certain perfumes and scents.All that and a round of The Game featuring scents that conjure up witches brews, 80s sodas, and gym socks. Yes, you read that correctly, gym socks.Fragrances mentioned in this episode:Meander, Guidance, and Crimson Rocks by Amouage / Flowerbomb by Viktor & Rolf / Heaven Can Wait, Iris Poudre, and Eau de Magnolia by Frederic Malle / Lavande 31 and Aldehyde 44 Dallas by Le Labo / Sadonosa by Nasomatto / Poudrextase and Carnicure by Marlou / Fierce by Abercrombie and Fitch / Fall Into Stars, Lost In Flowers, Melt My Heart, Dead of Night, and Silence the Sea by Strangelove NYC / Oud Satin Mood by Maison Francis Kurkdjian / Cologne 352 by Ex Nihilo / Sex & Jasmine by Libertine Fragrance / Violette Hay by Marissa Zappas / Bibliotheque by Byredo / Amber Teutonic and Amber Kiso by DS & Durga / Fille en Aiguilles by Serge Lutens / Ethereal Wave by LIIS / Hwyl by Aesop / Elle by Arquiste / Philosykos by Diptyque / Gris Charnel by BDK Parfums / M-Mink by Byredo / Cinematic, Match, and Pride by Der Duft / Feuille by Miskeo ParfumsThe Game:Carduus by Jorum Studio / Nanban by Arquiste / Casablanca by La Boticá / Bowmakers by DS & Durga / Canvas by Der Duft / Épices by Miskeo ParfumsPlease feel free to email us at hello@fragraphilia.com - Send us questions, comments, or recommendations. We can be found on TikTok and Instagram @fragraphilia
SOLO THIS WEEK with my reviews/[HOT] takes on the Le Labo City Exclusives, tips for picking a signature scents, how to identify notes in fragrances, some lesser known Hilde Soliani scents I am loving, and of course ANSWERING YOUR CALLS and doing listener scent consults! FRAGS MENTIONED: Le Labo: Gaiac 10, Bergamote 22; D'Orsay Nous Sommes Amants MD, Givenchy MMW, ERIS Parfums Scorpio Rising, Le Labo Myrrhe 55, YSL Opium, Givenchy L'Interdit, Le Labo Ylang 49, Byredo Rose Noir, Le Labo: Gaiac 10, Vetiver 46; Aesop Hwyl, Le Labo: Another 13, Santal 33, Vanille 44, Tonka 25, Musc 25; Jovan White Musk, Le Labo: Ambrette 9, Mousse de Chene 30; Baccarat Rouge 540, Le Labo: Another 13, Tubereuse 40, Jasmin 17, Cedrat 37, Citron 28, Limette 37, Bergamote 22, Neroli 36, Bigarade 18, Fleur D'Oranger 27, Benjoin 19, Cuir 28, Aldehyde 44, Baie Rose 26; Parfum D'Empire Le Cri et la Lumiere, Givenchy Prisme Libre Original Mousseline Pastel, Hilde Soliani: Crema di Latte, Hot Milk, Fragola Salata, Vecchi Rosetti; Frederic Malle Lipstick Rose, Chanel Coco, Chanel Coco Madamoiselle; Hilde Soliani Crema di Latte, Chabaud Lait Concentre, Liquides Imaginaires Blanche Bete, Hilde Soliani: Peccatrice, Buonissimo, Il Tuo Tulipano; Burberry Brit EDT, D.S. & Durga Debaser, Marissa Zappas Lilac Dream, Eccentric Molecules M01 + Iris, Gabar Ground II, Kismet Olfactive Wedding in Oaxaca, Le Labo The Matcha, Eccentric Molecules M01, Le Labo Santal 33, Jo Malone Wood Sage & Sea Salt, Glossier You, Chris Collins African Rooibos SHOP THIS EP: https://shopmy.us/collections/234149 DISCOUNTS CODES (eligible for commission): 10% off LuckyScent: code 10pr (for orders $40+) 10% off TwistedLily: code perfumeroom10
Welcome back to Neurotech Pub! In this first installment of two episodes on Connectomics, host and Paradromics CEO Matt Angle kicks off a lively discussion on the rapidly accelerating research in the mapping, preservation, and reconstruction of the human connectome. We explore the ethical and legal ramifications of disruptive technology, and some of the unique challenges faced when driving innovation in emerging industries. Our guests are: Nita Faraheny, JD, PhD, Everett Distinguished Professor of Law & Philosophy at Duke Law School, the Founding Director of Duke Science & Society, the Faculty Chair of the Duke MA in Bioethics & Science Policy, and principal investigator of SLAP Lab. Kenneth Hayworth, PhD, President and Co-Founder of the Brain Preservation Foundation, Senior Scientist at the Howard Hughes Medical Institute's Janelia Farm Research Campus (JFRC) Robert McIntyre, CEO at Nectome As an exciting new development since the recording of this episode, Nita recently published a book, The Battle for Your Brain, which examines many topics in neuroethics, from Connectomics to Brain-Computer Interfaces. It is currently available on Amazon.Keep an eye out for part two in this series, which will take a deep dive into the latest technical and engineering innovations in the connectomics ecosystem. Coming soon!Please be advised that this episode contains a brief discussion of assisted suicide in a medical setting.Show Notes: 0:00 | Episode Intro 1:16 | Nita A. Farahany, JD, PhD1:21 | Kenneth Hayworth, PhD1:27 | Robert McKintyre, CEO, Nectome1:56 | Meeting of the minds 2:53 | Aldehyde-stabilized cryopreservation wins final phase of brain preservation prize3:56 | The Brain Preservation Foundation4:09 | Documentary series on the Brain Preservation Foundation5:21 | Letter of Support for Aldehyde Stabilized Cryopreservation (and ‘next steps' caveats)5:51 | Nita's 2018 Neuroethics Ted Talk 5:54 | International Neuroethics Society6:25 | Connectomics & new paths in neuroscience 8:10 | Allen Institute for Brain Science8:47 | A connectome and analysis of the adult Drosophila central brain9:33 | A visual intro to synaptic imaging in connectomics10:28 | The structure of the nervous system of the nematode Caenorhabditis elegans 11:16 | Mouse Connectome Project at CIC14:59 | Cryonics controversy 19:00 | Death, taxes, and synapses 20:51 | Uniform Law Commission21:08 | The Uniform Determination of Death Act24:25 | Watch Altered Carbon on Netflix25:49 | Understanding the “Loss of Chance” Doctrine 37:13 | Understanding Physician-Assisted Death, or ‘Death with Dignity' 40:21 | Euthanasia in the Netherlands46:01 | Autonomy, Dignity, and Consent to Harm, Rutgers Law Review Want More?Follow Neurotech Pub on TwitterFollow Paradromics on Twitter, LinkedIn, and InstagramFollow Matt on LinkedIn and Twitter
Link to bioRxiv paper: http://biorxiv.org/cgi/content/short/2023.01.11.523573v1?rss=1 Authors: Bhalla, M., Shin, J. I., Ju, Y. H., Park, Y. M., Yoo, S., Lee, H., Lee, C. J. J. Abstract: GABA (gamma-aminobutyric acid) is the primary inhibitory neurotransmitter in the CNS. In astrocytes, GABA is synthesized by degradation of putrescine by monoamine oxidase B (MAO-B), a process which is known to mediate tonic inhibition of neuronal excitability. This astrocytic tonic GABA and related enzymes are also reported to be involved in memory impairment in Alzheimers Disease, and therefore are potential therapeutic targets to rescue memory in AD patients. However, the enzymes downstream of MAO-B in this pathway have not been elucidated yet. To fill this gap in knowledge, we performed transcriptomic and literature database analysis and identified Aldehyde dehydrogenase 1 family, member A1 (ALDH1A1) and a histone deacetylase enzyme Sirtuin2 (SIRT2) as plausible candidate enzymes in primary cultured astrocytes. Immunostaining, metabolite analyses, and sniffer patch clamp performed in the presence or absence of suitable inhibitors, or with genetic ablation of the candidate enzymes recapitulated their participation in GABA production. We propose ALDH1A1 and SIRT2 as potential therapeutic targets against Alzheimers Disease. Copy rights belong to original authors. Visit the link for more info Podcast created by Paper Player, LLC
This week we discuss Aldehydes. What are they? What are they used for? And why do they smell like being poor? There's a lot going on in this episode, but key takeaways are the tips on how to smell like a Russian mobster, a 90s rubberised mascot or washed up X-Factor winner. You can contact us via email at lesoderants@gmail.com or via Instagram: Dan: fragrance_weirdo James: houdini_sotd Ben: talking_scents Fliss: fliss_sniffs_stuff During the show we may mention perfumes that were sent to us for review. We will, at all times, be completely transparent about this when it is the case and I hope you'll come to trust us enough to see that whatever the method of acquisition, we will always speak our own minds about said perfume and/or house.
This episode is sponsored by BTG Speciality Pharmaceuticals. BTG provides rescue medicines typically used in emergency rooms and intensive care units to treat patients for whom there are limited treatment options. They are dedicated to delivering quality medicines that make a real difference to patients and their families through the development, manufacture, and commercialization of pharmaceutical products. Their current portfolio of antidotes counteracts certain snake venoms and the toxicity associated with some heart and cancer medications. --- Dr. Weiss is a Founding Member of the Musculoskeletal Oncology Research Initiative (MORI), Pittsburgh Cure Sarcoma (PCS), the Pittsburgh Sarcoma Research Collaborative (PSaRC), and the Pittsburgh Center for Bone and Mineral Research (PCBMR). He is a peer reviewer for multiple journals including the Journal of the American Academy of Orthopaedic Surgeons, BioMed Central Cancer, Sarcoma, Cancer Research, International Journal of Cancer, and others. He is a former member of the NIH's Center for Scientific Review Early Career Reviewer program. He has served on multiple National Cancer Institute Study Sections. He is a member of the Musculoskeletal Tumor Society (MSTS) for which he serves as Chair of the Research Committee and the Connective Tissue Oncology Society (CTOS), for which he has served on the Board of Directors. --- What We Do at MIB Agents: PROGRAMS: ✨ End-of-Life MISSIONS ✨ Gamer Agents ✨ Agent Writers ✨ Prayer Agents ✨ Healing Hearts - Bereaved Parent Support ✨ Ambassador Agents - Peer Support ✨ Warrior Mail ✨ Young Adult Survivorship Support Group ✨ EDUCATION for physicians, researchers and families: ✨ OsteoBites, weekly webinar & podcast with thought leaders and innovators in Osteosarcoma ✨ MIB Book: Osteosarcoma: From our Families to Yours ✨ RESEARCH: Annual MIB FACTOR Research Conference ✨ Funding $100,000 annually for OS research ✨ MIB Testing & Research Directory ✨ The Osteosarcoma Project partner with Broad Institute of MIT and Harvard ... Kids are still dying with 40+ year old treatments. Help us MakeItBetter.
Criopreservación: En este capítulo hablamos sobre la criopreservación de la vida, en específico la criogenización de las células animales. Abarcando desde sus inicios y sus primeros investigadores, las bases biotecnológicas que se consideran para preservar células sin llegar a la congelación, hasta los países y compañías que actualmente cobran por criogenizar el cuerpo completo o la cabeza de las personas. En específico mencionaremos dos casos que han dado pie a la apertura de la aplicación, el primero es el caso de Einz, la humana más pequeña en ser criogenizada debido a su enfermedad y el estudio de sus padres. El segundo caso, un poco más alentador ya que demuestra un proyecto de investigación con éxito en el que se criogenizaron cerebros de conejo. T4E7 *** McIntyre, R. L., & Fahy, G. M. (2015). Aldehyde-stabilized cryopreservation. Cryobiology, 71(3), 448–458. doi:10.1016/j.cryobiol.2015.09.003 Lovat, A. M. (2016). Ectogénesis y criogenización humana. desde el inicio del ser hasta su reanimación tras la muerte. principios éticos y criterios de convergencia. Ratio Iuris. Revista de Derecho Privado, 4(1), 25-55. http://dspace.uces.edu.ar:8180/xmlui/bitstream/handle/123456789/3582/Ectog%c3%a9nesis_Lovat.pdf?sequence=1 Braddock, M. (2018). Concepts for Deep Space Travel: From Warp Drives and Hibernation to World Ships and Cryogenics. Current Trends in Biomedical Engineering & Biosciences, 12(5), 1-4. DOI: 10.19080/CTBEB.2018.12.555847 Sa. (2012).Cryogenesis: A Review. Dartmouth Undergraduate Journal of Science. https://sites.dartmouth.edu/dujs/2012/03/11/cryogenesis-a-review/ Brown, E. (2011). Robert Ettinger, founder of the cryonics movement, dies at 92. https://www.washingtonpost.com/local/obituaries/from-phyics-teacher-to-founder-of-the-cryonics-movement/2011/07/24/gIQAupuIXI_story.html Lledó, F. & Monje, O. (2019). Reflexiones documentadas en torno al debate de la criogenización del cuerpo humano fallecido. El derecho a vivir después de la muerte. https://revistas.ucu.edu.uy/index.php/revistadederecho/article/view/1875/1829 Postigo, E. (2021).TRANSHUMANISMO, MEJORAMIENTO HUMANO Y DESAFÍOS BIOÉTICOS DE LAS TECNOLOGÍAS EMERGENTES PARA EL SIGLO XXI. Cuadernos de bioética, 32(105), 132-139. DOI: 10.30444/CB.92 Kowalski, D. (2021). Cryonics is a visionary concept that holds out the promise of a second chance at life - with renewed health, vitality and youth. Cryonics Institute, Technology for Life. https://www.cryonics.org/about-us/ Wilson, P. (2021). The Cryonics Industry Would Like to Give You the Past Year, and Many More, Back. The New York Times. https://www.nytimes.com/2021/06/26/style/cryonics-freezing-bodies.html *** El podcast de Colectivo Motus es producido por MotusLab. El guion y la voz fueron realizados por María Margarita Morales Cortés, Kathia Esquivel Zaragoza y Ximena García Gómez; la edición de audio por Nadia Cea y Vicente Castillo. La ilustración de portada, por Gabriel de los Santos. Agradecimientos a Ana Hernández Ledesma, Elisheba Morales, Valeria Caltzontzin y Christopher Cedillo por la revisión y comentarios del contenido. Agradecimientos a quienes revisaron y comentaron el guion. *** ¡Sigue estas redes! Divulgación de la ciencia y a veces cosas de arte: https://www.instagram.com/colectivomotus El de la voz y guion de este episodio: @magggie_morales, @kathia_esquivel, @g.g.ximena Grupo: Sebiotec Querétaro Correo electrónico: sebiotec.qro@gmail.com Redes: @sebiotec.qro https://blog.motuslab.xyz/ colectivomotus@gmail.com
Who? What? Where? When? Why? All up to date? Good. Join me on a brief journey of self voyage into the word of the day. Today's word is - "Aldehyde". Come with me and find out what the meaning/definition of the word is. You may (probably not) learn something new. Thank you for listening. Have a great day/afternoon/evening (delete as applicable) Don't forget to find me on the socials (not in a weird way) and please listen to more. Word.
Yves Saint Laurent Y hier günstig bestellen ► https://amzn.to/37gxeVX GIRLS! Online Programm für mehr Dates & Frauen ► https://www.premiumlife.tv/girls/ YVES SAINT LAURENT Y REVIEW: Yves Saint Laurent Y Eau De Perfume - Kreativität, Leidenschaft und Erfolg – Erschaffe die Welt von morgen mit dem neuen Y Eau de Parfum von Yves Saint Laurent. Entdecke eine neue Intensität des Dufts für den Mann, der etwas riskiert, um seine Träume zu verwirklichen. Denn was ist deine Leidenschaft? Wofür kämpfst du? Woran glaubst du? Wovon träumst du? Wer bist du? Die Antwort findest du im einmaligen Dufterlebnis für den Mann. Denn weiße Aldehyde und Geraniennoten in Verbindung mit Weihrauch und grauem Amber, machen Y zum ersten weißen und dunklen Fougère. Die olfaktorische Pyramide: - Bergamot Öl, Primofiore-Zitronenöl, Elemi Öl, Ingweröl, Weiße Aldehyde - Wacholderbeerenöl, Muskatellersalbei, Geranie, Lavendelöl - Zedernholzöl, Tannenbalsam, Weihrauch, Grauer Amber Akkord, Vanillen Akkord. Sei du selbst. Jeden Tag. Mit Y. Yves Saint Laurent Y Eau de Parfum: Holzig, weißer und dunkler Fougère. Für den Mann, der sich immer zu Höchstleistungen anspornt. Für eine langanhaltende Duftwirkung sprühe Yves Saint Laurent Y aus 2 cm Entfernung auf die Haut. Besonders geeignet sind warme Körperbereiche z.B. die Innenseite der Handgelenke und der Kopfbereich direkt hinter den Ohren. Duftnoten: Bergamotte, Ingwer, Apfel. PREMIUM LIFE – DATING & LIFESTYLE CLUB Lebe das Leben, wovon Du immer geträumt hast! Mit unserem einzigartigen GIRLS! Programm zu mehr Dates, mehr Frauen, mehr Spaß und einem großartigen Lebensgefühl. In 9 Schritten ganz automatisch mehr Frauen in Dein Leben ziehen. Im Online Dating, Nachtleben & Alltag. Jederzeit & überall. Jetzt starten und es selbst erleben: ► https://www.premiumlife.tv/girls/ SOCIAL MEDIA: Für all Deine (privaten) Fragen und weiteren einzigartigen Dating & Lifestyle Content stehen wir Dir gerne auf folgenden Social Media Apps zur Verfügung. Amazon: https://www.amazon.de/shop/premiumlife Facebook: https://www.facebook.com/premiumlifetv Facebook Gruppe: https://www.facebook.com/groups/PremiumLife/ Instagram: https://www.instagram.com/premiumlife.tv/ Snapchat: https://www.snapchat.com/add/premiumlife.tv Spotify: https://spoti.fi/2SMb2ee Telegram (Adults Only, nur 18+ Content): t.me/premiumlife18 TikTok: https://www.tiktok.com/@premiumlife.tv Twitter: https://twitter.com/PremiumLife_TV Website: https://www.premiumlife.tv/
Aldehyde Neurotoxins are the brains behind man-y health challenges, people are exposed to, nowadays. Bu-t you can change the game play, with Acupressure.
Talk to a Dr. Berg Keto Consultant today and get the help you need on your journey (free consultation). Call 1-540-299-1557 with your questions about Keto, Intermittent Fasting or the use of Dr. Berg products. Consultants are available Monday through Friday from 8:30 am to 9 pm EST. Saturday & Sunday 9 am to 5 pm EST. USA Only. Take the Free Keto Mini-Course: bit.ly/KetoMiniCourse Intermittent Fasting Basics: bit.ly/DrBergIF Sensitive to Sulfites: https://www.youtube.com/watch?v=_GhQ9... Today, I want to cover a really fascinating trace mineral called molybdenum. What is molybdenum? Molybdenum is a coenzyme for many chemical reactions in the body. Foods high in molybdenum: • Legumes • Grains (not keto-friendly) • Nuts • Eggs • Green beans • Sunflower seeds Sulfite oxidase - Converts sulfites into sulfur compounds. You need this enzyme to detox the liver, make glutathione, and to make certain compounds in your joints. Aldehyde oxidase - Involved in getting rid of the candida die off. It's also involved in breaking down drugs. Xanthine oxidase - Turns certain proteins into uric acid. Molybdenum is involved in detoxification, and without it, things can become toxic. If you have a problem with detoxification, molybdenum is the trace mineral you would want to take. Dr. Eric Berg DC Bio: Dr. Berg, 51 years of age is a chiropractor who specializes in weight loss through nutritional & natural methods. His private practice is located in Alexandria, Virginia. His clients include senior officials in the U.S. government & the Justice Department, ambassadors, medical doctors, high-level executives of prominent corporations, scientists, engineers, professors, and other clients from all walks of life. He is the author of The 7 Principles of Fat Burning. FACEBOOK: fb.me/DrEricBerg?utm_source=Podcast TWITTER: http://twitter.com/DrBergDC?utm_source=Podcast YOUTUBE: http://www.youtube.com/user/drericberg123?utm_source=Podcast DR. BERG'S SHOP: https://shop.drberg.com/?utm_source=Podcast MESSENGER: https://www.messenger.com/t/drericberg?utm_source=Podcast DR. BERG'S VIDEO BLOG: https://www.drberg.com/blog?utm_source=Podcast
Diese Folge steht im Zeichen des Chroms, das seinen Namen seiner farbigen Verbindungen verdankt. In Freiraum reden wir über die Folgen des Klimawandels für die Ernährung und über Erfinder mit D wie Dethloff, Dehmelt und - Düsentrieb. In Moleküle geht es um die Aldehyde und Oxidationszahlen, und in Wie funktioniert...? werden Parabolrinnenkraftwerke erklärt. Zum Schluss gibt es Musik - diesmal ohne Geschwätz im Hintergrund und als Gastbeitrag erklärt uns oboeman die "chromatischen Tonleitern"
In this episode we discuss: E-Juice Review: Capone by The Sauce LA Take Part In The Annual ECigIntelligence Vaper Survey Battery Updates on Enercig, Molicel, and Sony VTC5Aa A Replication Study Disproves Another Previous Aldehyde Study England E-Juice Company Nerudia Purchased by Imperial Big Tobacco News: Altria Has Invested in Avail Vapor Naked 100 is now selling nicotine salt-based versions of their e-juices Show notes can be found on this episode's page on VapePassion.com Subscribe to the VapePassion YouTube channel --- Support this podcast: https://anchor.fm/the-vapepassion-podcast-vaping--electronic-cigarettes/support
Tierärztliche Fakultät - Digitale Hochschulschriften der LMU - Teil 07/07
Glioblastoma multiforme (GBM) is the most common malignant primary brain tumour in adults with a median survival, despite of multimodal aggressive therapy, of only 15 months. Relapse occurs inevitably because of the infiltrative nature of GBM. To date, only the MGMT promoter methylation is a reliable marker for therapy sensitivity. Survival-associated prognostic factors as well as novel therapy targets are urgently needed. Multiple genetic and metabolic pathway alterations contribute to tumour progression and therapy resistance. Recently proposed CSC markers for solid cancers include the aldehyde dehydrogenase (ALDH) superfamily. This cytoplasmic enzyme family consists of 19 different isoforms. The ALDH enzymes act upon oxidative stress and participate in proliferation, differentiation, and cell cycle arrest. The evolutionary conservation of the protein family enables comparative considerations of different species. In the presented study, isotype specific expression of ALDH is analysed in human GBM tumours and in two commonly used mouse GBM models. Expression of ALDH in the mouse models is then compared with the human GBM to find a suitable model for further research. The presented results indicate that there is, though challenging, a necessity for isotype specific analysis of ALDH expression. ALDH1A1 immunohistochemical expression in human PGBM was found primarily in the tumour adjacent region, whereas ALDH1A3 positive cells were more frequently found among tumour cells. Prognostic relevance for PGBM patients’ outcome was found for the ALDH1 immunohistochemical expression. Moreover, female PGBM patients were shown to have prolonged survival if neither ALDH1A1 nor ALDH1A3 expression is present. For male PGBM patients, ALDH1A1 and ALDH1A3 immunohistochemical expression could not be correlated to the medium overall survival. The reasons for this gender difference remain yet undetermined. Both the murine and the human GBM cells analysed in this thesis did not show ALDH1A1 immunohistochemical expression in cell culture or after implantation. The expression of ALDH1A3 is inhomogeneous in the analysed groups, raising further questions, which will be investigated in the future.The investigative approach of this thesis showed that the analysed canine GBM samples express ALDH1A3 but not ALDH1A1. This difference to human PGBM tumours in ALDH expression can help to understand more about the metabolic processes in tumour cells and the reactions to the tumour cells in the surrounding tissue. Finally, there are two particularly promising research subjects for future investigations: the gender specific prognostic power of ALDH expression in PGBM patients and the reason for the change in ALDH1A3 expression between in vitro and in vivo conditions. This knowledge can contribute to finding new targets for PGBM therapy and to prolonging patient survival.
KOKU'da bu hafta: Guerlain hikayesi devam ediyor: bu kez kuzen Jacques isbasinda; Klodfarer Sirkeci'de bir cadde olmaktan baska nedir?; Cyphre parfum ailesi nedir?; "Mitsouko"; Aldehyde'ler; Jean Paul, Jacques'dan el aliyor. Kendi sesinden Jean Paul Guerlain.
Aldehyde and ketone nomenclature; preparation of aldehydes and ketones; oxidation;hydration; cyanohydrin formation; Grignard and hydride reactions; imine and enamine formation; acetal formation; Wittig reaction; conjugate addition; spectroscopy
The compound hydroxylamine is remarkably close in structure to ammonia, and differs only in containing an additional hydroxyl, thereby giving it basic properties. Normally a crystalline compound at room temperature, this base is also known to play significant roles as a reducing agent as well as in imine formation.Imines are highly reactive nitrogen double-bond containing compounds that are formed through an addition reaction with a carbonyl group in acidic conditions (aldehyde/ketone): Despite their rather explosive nature, hydroxylamines are useful compounds in themselves or in their other derived forms.For more information on hydroxylamines, click on this link.1). Hydroxyammonium NitrateBeing the salt of hydroxylamine and nitric acid (via an acid-base reaction), this corrosive and toxic substance is held in high regard by rocket scientists, as this compound is considered to be a potential rocket propellant. The following shows the synthetic mechanism of creating this compound:Click on this link for more information on the properties of the energetic compound hydroxyammonium nitrate and its significant use as a rocket propellant.Click on this link directing to a Chem 243 lecture describing the various reactions of aldehydes and ketones (including imine formation).2). Separation of Aldehydes and Ketones using Oxime DerivativesIn the case of hydroxylamines, the resulting imine products that are formed from their interaction with a carbonyl in acidic conditions results in the formation of a special subset of imines known as oximes (from aldehyde – aldoxime/from ketone – ketoxime). Oximes are normally colorless crystalline compounds. In fact, it is this property of these compounds that allow for their usage in determining the identity of the respective aldehyde/ketone that the hydroxylamine originally reacted with. In the following example, the use of the hydroxylamine derivative para-nitrobenzyl hydroxylamine is reacted with the respective carbonyl compound. As a result, the new compound is easily able to be detected and identified through separation techniques such as High Performance liquid Chromatography (HPLC), as the nitro groups increase molar absorptivity and increased sensitivity. In addition, alkylated oxime groups are more easily seperated by the technique HPLC than standard ones.As the peer article referred to didn’t provide a mechanism as to how the p-nitrobenzyl hydroxylamine was synthesized, I have provided a sample mechanism that leads to its production:This link leads to the respective peer review article referred to in obtaining this information.Click on one of the following three links that direct to Chem 243 lectures for information on:A) Electrophillic Aromatic Substituion (use of Friedel-Crafts Alkylation in order to add a methyl group to a benzene ring).B) Ortho/Para Vs. Meta Directing Groups (ability of methyl group on benzene ring to direct the respective nitro group being added on through a nitration reaction to a para position).C) Side Chain Reactions of Aromatic Compounds and introduction to Aldehyde and Ketone properties (substitution of methyl's hydrogen on the benzyl position with bromine through free radical halogenation).3. Synthesis of CaprolactamCaprolactam is one the many monomeric subunits used in the overall synthesis of the material Nylon-6. Once an imine synthetic reaction is performed on a cyclohexanone with a hydroxylamine, the resulting product can be converted into caprolactam through a specific reaction known as the Beckmann Rearrangement. The Beckmann Rearrangement is an acid catalyzed reaction that allows for the conversion of an imine into an amide, as seen below:For more information on the synthetic properties of the formed caprolactam, please click on this link.Compound InfoHydroxylamine: PubChem 789 hydroxylamine Oxammonium Oxyammonia Nitroxide NH2OHChemACXnet to purchase ACX number X1008257-2 CAS number 7803-49-8
Fakultät für Chemie und Pharmazie - Digitale Hochschulschriften der LMU - Teil 02/06
Im Rahmen der Dissertation "Metall-katalysierte enantioselektive Synthese von Propargylaminen und ihre Anwendungen in der Synthese" wurde eine Kupfer-katalysierte enantioselektive Additionsreaktion von Alkinen an in situ generierte Iminium-Ionen untersucht. Zunächst wurde eine neuartige Eintopf-Synthese entwickelt, die eine besonders atomökonomische und synthetisch wertvolle Methode zur Darstellung der Propargylamne darstellt. Dabei wurden equimolare Mengen von terminalen Alkinen, Aldehyden und sekundären Aminen in Gegenwart von katalytischen Mengen Kupferbromid und Quinap als chiralem Ligand umgesetzt. Die Methode toleriert Variationen und die Einführung von funktionellen Gruppen in alle drei Komponenten. Insbesondere die Ausweitung der Synthese auf aromatische Aldehyde ist erwähnenswert. Die auf diesem Wege erhaltenen Propargylamine wurden weiter funktionalisiert und so in synthetisch nützliche Derivate überführt. Unter anderem wurde die synthetische Anwendbarkeit in der enantioselektiven Totalsynthese des Alkaloids Coniin demonstriert. Im zweiten Teil der Dissertation wurde der Einfluß der Stickstoff-Schutzgruppen auf die Enantioselektivität der Reaktion untersucht. Dabei wurden verschiedene neue Schutzgruppen entwickelt. Der Einsatz von Di(2-phenallyl)amin in der Propargylaminsynthese erlaubte nach einer Palladium-katalysierten allylischen Substitution an den allyl-geschützten Propargylaminen die Darstellung primärer Propargylamine, die bis dahin nicht in guten Enantioselektivitäten zugänglich waren. Im abschließenden Teil der Dissertation wurde ein neuartiger, chiraler P,N-Ligand ausgehend von chiralen Propargylalkoholen entwickelt und in der asymmetrischen Synthese (Palladium-katalysierte allylische Substitution) getestet.
Fakultät für Biologie - Digitale Hochschulschriften der LMU - Teil 01/06
Untersucht wurde das geruchliche Unterscheidungsvermögen von Totenkopfaffen und Menschen zum einem für jeweils eine homologe Reihe von aliphatischen Aldehyden und Ketonen, zum anderen für ausgewählte Vertreter enantiomerer Duftstoffe. Dabei ergab sich für den Bereich der aliphatischen Aldehyde und Ketone folgendes Bild: Menschen und Totenkopfaffen verfügen über ein sehr gutes geruchliches Unterscheidungsvermögen bezüglich der hier verwendeten homologen Reihen von aliphatischen Aldehyden und Ketonen. Bei beiden Spezies zeigte sich eine signifikante negative Korrelation zwischen der Diskriminationsleistung und der strukturellen Ähnlichkeit (bezogen auf die Kohlenstoffkettenlänge) der Stimuli. Die Position der funktionellen Gruppe im Stimulusmolekül hatte ebenfalls deutliche Auswirkungen auf die geruchliche Qualität und somit auf die Diskriminierbarkeit des jeweiligen Duftstoffes. Bezüglich der Enantiomer-Diskrimination zeigte sich bei den drei Enantiomerpaaren (+)- versus (–)-a-Pinen, (+)- versus (–)-Carvon und (+)- versus (–)-Limonen eine gute Übereinstimmung des geruchlichen Diskriminationsvermögens von Menschen und Totenkopfaffen. Diese Aufgaben wurden vom Humankollektiv und, von einer Ausnahme abgesehen, von den Totenkopfaffen signifikant über Zufallsniveau richtig gelöst. Am leichtesten fiel beiden Spezies dabei die geruchliche Diskrimination der Antipoden des a-Pinens. Die Diskriminationsaufgabe (+)- versus (–)-Fenchon konnte nur von den drei Totenkopfaffen signifikant richtig gelöst werden. Die geruchliche Unterscheidung der restlichen sechs getesteten Enantiomerpaare war beiden Spezies nicht möglich. Die gute Übereinstimmung der geruchlichen Leistungsfähigkeit von Humankollektiv und Totenkopfaffen legen den Schluß nahe, daß die olfaktorische Wahrnehmung von menschlichen und nicht-menschlichen Primaten auf den selben molekularen Mechanismen beruht. So hat die Anzahl der in einem Duftmolekül enthaltenen Kohlenstoffatome wie auch der sterische Aufbau dieses Moleküls bei beiden Spezies einen entscheidenden Einfluß auf die wahrgenommene Duftqualität.
Sun, 1 Jan 1989 12:00:00 +0100 http://epub.ub.uni-muenchen.de/3936/ http://epub.ub.uni-muenchen.de/3936/1/088.pdf Cambanis, Anton; Bäuml, Englbert; Mayr, Herbert Cambanis, Anton; Bäuml, Englbert und Mayr, Herbert (1989): Formylation of Allylsilanes. A Synthesis of β,γ-Unsaturated Aldehyde Acetals. In: Synthesis: pp. 128-129. Chemie und Ph
Es wird eine Regel zur Bestimmung der Absolutkonfiguration von chiralen -hydroxysubstituierten Nitrilen, Alkinen und Aldehyden des Typs 2 beschrieben, welche auf der Enantiomer-Selektivität von Acetalisierungsreaktionen solcher Verbindungen mit einem Lactol des Typs 1 beziehungsweise auf charakteristischen Verschiebungsunterschieden in den Kernresonanzen der diastereomeren Acetale 3 und 4 beruht.