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CAR-T Therapy is one of the most talked about advances in autoimmune research today, offering new hope for people living with AiArthritis diseases such as lupus, myositis, scleroderma, and Sjögren's. In this episode, co-hosts Leila P.L. Valete, AiArthritis Health Education Manager, and Tiffany Westrich-Robertson, CEO and Original Founder of AiArthritis, explain what CAR-T is, how it works, and why it matters. They walk through the treatment process step by step from collecting a person's own immune cells, to reprogramming them in a lab and reintroducing them so the immune system can reset. This episode highlights promising results from early clinical trials including patients reaching remission and stopping other medications, while also addressing safety, access, and what is still unknown. Whether you're a patient, caregiver, researcher, or advocate, this episode explains what's happening in CAR-T research and why it could represent a major shift in how AiArthritis diseases are treated.   Donate to Support the Show: www.aiarthritis.org/donate   Episode Highlights: What CAR-T Therapy is and how it works with AiArthritis diseases Why B cells are an important target in conditions like lupus and Sjögren's Early results from clinical trials showing remission and organ improvement Safety considerations for patients in CAR-T studies Who may qualify now through trials, and what wider access could look like in the future How to stay informed on CAR-T research   Links & Resources: Sign up for Go With Us! to Conferences program: www.aiarthritis.org/gowithus Sign up for the Research Database: www.aiarthritis.org/database Have questions about this episode or topics you want to hear us bring to the table? Email us at podcast@aiarthritis.org  Follow AiArthritis on all social media platforms @IFAiArthritis Sign up for our Monthly AiArthritis Voices 360 Talk Show newsletter! HERE   Connect with our Co Hosts: Leila is the Health Education Manager at the International Foundation for AiArthritis. She is a person living with Lupus and Sjögren's disease. She is passionate about inclusion and diversity in health education and meeting individuals where they are at in order to learn in a way that resonates with them. Connect with Leila:     Instagram: @lupus.lifestyle.lei      LinkedIn: https://www.linkedin.com/in/leila-pl-valete/       Facebook: @leilaaiarthritis      TikTok: @lupus.lifestyle.lei   Tiffany is the CEO at International Foundation for AiArthritis and uses her professional expertise in mind-mapping and problem solving to help others, like her, who live with AiArthritis diseases work in unison to identify and solve unresolved community issues. Connect with Tiffany: Facebook: @tiffanyAiArthritis Twitter: @TiffWRobertson LinkedIn: @TiffanyWestrichRobertson

In this highlight reel episode of Grow Everything, hosts Erum Azeez and Karl Schmieder dive deep into the rapidly evolving world of decentralized science (DeSci). Featuring expert insights from Albert Anis, Jocelyn Pearl, Michael Fisher, and Laura Minquinin, this episode explores how DeSci is revolutionizing the way research is funded, shared, and governed — far beyond traditional academic systems. You'll hear how blockchain, bioDAOs, and decentralized funding models are enabling faster, more collaborative innovation across the life sciences. Whether you're a researcher, founder, or biotech enthusiast, this conversation unpacks the tools, values, and infrastructure reshaping the future of scientific discovery. From autonomous agents designing experiments to the Solana-based $BIO token, this episode distills cutting-edge developments into a compelling introduction to the DeSci movement — and why it matters now more than ever.Grow Everything brings the bioeconomy to life. Hosts Karl Schmieder and Erum Azeez Khan share stories and interview the leaders and influencers changing the world by growing everything. Biology is the oldest technology. And it can be engineered. What are we growing?Learn more at www.messaginglab.com/groweverythingChapters:(00:00:15) Welcome to the Grow Everything Podcast(00:00:44) Travels and reading Bossy Pants(00:01:34) Highlighting September as Blood Cancer Awareness Month(00:02:20) Innovations in biopharma and cancer therapies like CAR T(00:02:53) The science of how sleep flushes waste from the brain(00:04:07) A deep dive into sulforaphane for cognitive benefits(00:05:07) The challenge of getting effective quantities of molecules from food(00:06:20) Introducing Decentralized Science (DeSci)(00:07:05) Why DeSci is important: Democratizing science and making it accessible(00:09:08) DeSci's role as an alternative funding mechanism for scientific research(00:10:54) Defining DeSci as science improved by the blockchain(00:11:27) How token incentives work in DeSci research projects(00:12:56) Contrasting DeSci's crowdsourcing model with traditional science funding(00:14:43) Defining a DAO (Decentralized Autonomous Organization)(00:15:46) The origins of decentralized science and ValleyDAO(00:18:35) Explaining DeSci by comparing it to decentralized finance (DeFi)(00:19:40) How the broken scientific publishing model needs disruption(00:20:50) Breaking open the "black box of biotech" with LabDAO(00:22:40) DeSci as a tool to fund overlooked areas of research(00:22:57) How DeSci addresses major problems like publishing and reproducibility(00:23:43) The mission of Athena DAO to fund women's health research(00:25:33) DeSci movement(00:26:09) The idea of a DeSci-funded cloud lab for global collaborationEpisode Links:Michael Fischer episodeJocelynn Pearl episodeAlbert Anis episodeLaura Minquini episode How Your Brain's Nightly Cleanse Keeps It HealthyDeSci WikiBioFab Fair - Use promo code: GROW10 for a discount to attend! Topics Covered: biotech beauty, space biotech, skin care, biomanufacturing, longevity, extremophiles  Have a question or comment? Message us here:Text or Call (804) 505-5553Instagram  / Twitter / LinkedIn / Youtube / Grow Everything

The 5-year+ follow-up from CARTITUDE-1 has people asking if cilta-cel can cure multiple myeloma? We discuss this data and the broad comparison to the other BCMA-targeting CAR-T product, idi-cel and a recent comparison on plasma cell leukemia. CARTITUDE-1 Long-Term F/U: https://doi.org/10.1200/JCO-25-00760 Cilta-cel & ide-cel in plasma cell leukemia: https://doi.org/10.1182/bloodadvances.2025016966

Sponsored by the A&M Consumer and Retail Group, Mirakl, Ocampo Capital, Infios, and Quorso. Waitrose pilots AI-powered smart trolleys in Bracknell, becoming the first UK supermarket to test the technology. Chris and Anne remain skeptical about customer adoption hurdles and question why retailers are first in the water on unproven smart cart solutions. For the full #fastfive episode head here: https://youtu.be/838xKELS_nI #retailnews #retailtech #waitrose #trolley #retailmedia #ecommerce #retailinnovation #omnichannel #customerexperience #retailtrends #aiinretail

Leis aprovadas graças ao lobby de cartórios abriram brechas para privilégios para desembargadores, “penduricalhos” para promotores e supersalários para tabeliães. No novo episódio do podcast UOL Prime, apresentado pelo jornalista José Roberto de Toledo, a repórter Juliana Sayuri conta os bastidores da investigação, feita em parceria com o colunista Tiago Mali, para a série “Brasil dos Privilégios”. #uolprime⁠⁠⁠⁠⁠⁠ #PodcastUOLPrime⁠⁠

In this episode, editor in chief Joseph E. Safdieh, MD, FAAN, highlights articles about a promising blood test to distinguish Parkinson's disease from dementia with Lewy bodies, how CAR T-cell therapies are showing potential for patients with glioblastoma, and a new wireless electroencephalogram device that can even monitor young children with epilepsy.

In this week's episode, we'll learn about how TET2 is often mutated in myeloid malignancies and clonal hematopoiesis. In new work, expansion of Tet2-mutant HSPCs was dependent on Ncoa4, the cargo receptor mediating ferritinophagy. We'll iron out the implications. After that: a double-oh-seven license to kill in T-cell leukemia/lymphoma. WU-CART-007 is an off-the-shelf CAR T product with manageable safety and encouraging efficacy. With further work, it could become a new option for patients in urgent need of therapy. Finally: a comprehensive genetic study of classical Hodgkin lymphoma using circulating tumor DNA. This new research provides novel and complex insights on genetic subtypes, prognostic biomarkers, neoantigens in the disease environment, and more.Featured Articles:An in vivo barcoded CRISPR-Cas9 screen identifies Ncoa4-mediated ferritinophagy as a dependence in Tet2-deficient hematopoiesisPhase 1/2 trial of anti-CD7 allogeneic WU-CART-007 for patients with relapsed/refractory T-cell malignanciesA comprehensive genetic study of classic Hodgkin lymphoma using circulating tumor DNA

We're kicking off this season of Entrepreneurs Exposed, with a continuing conversation with the Co-Founder of BOLD Commerce, Jay Myers (round 1 see EP #181).  In this one, we explore so many corners of eCommerce, VC investing, podcasting, subscription commerce, loyalty, membership, and more. Enjoy! Learn more about your ad choices. Visit megaphone.fm/adchoices

Because it was dude.See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

Hey, friend. I'm pulling an amazing episode from the archives with over 400 episodes here on the Proof to Product podcast. There is a gold mine of information for you to help you grow your business, and, frankly, it can be hard to take it all in. Today's episode is a look back at one of our most downloaded episodes, discussing how to utilize abandoned cart email automations to drive more sales.  The holidays are coming up, and it's a perfect time to look at your email strategy and touch base with your hottest leads.  If you have ever shied away from sending out these emails, you are going to want to listen to this one and rethink your strategy. Did you know that almost 70% of shoppers abandon their online shopping carts and don't follow through with a sale?  That means that only 3 out of 10 of your customers who go to your website and load up their shopping cart complete their purchase. The same report from Baymard Institute said that more than $18,000,000,000 in e-commerce sales are lost annually due to abandoned carts. That is a whole lot of money. And yet, only some independent product brands are utilizing abandoned cart follow-up emails to recapture some of these sales.  Today's episode is sponsored by our Unlock Buyer Secrets Interview series. To make a strong first impression with wholesale buyers, we need to do a few things really well: We need to make it easy for stores to purchase from us We need to have clear pricing and terms & conditions We need to clearly communicate and add value at each touchpoint We need to focus on building strong relationships with our customers. And all of this becomes infinitely easier when we actively listen to our customers. This on-demand interview series will give you a competitive edge by providing an exclusive window into what buyers want and need from you. And, the best part, its only $27 bucks.  Get Access to the Unlock Buyer Secrets Interview Series You can view full show notes and more at http://prooftoproduct.com/336  Quick Links: Free Wholesale Audio Series Free Resources Library Free Email Marketing for Product Makers PTP LABS Paper Camp

If you're thinking about starting your mobile coffee cart to cater weddings and events, you'll find tons of helpful advice on tackling events in this episode. We just catered a wedding with our mobile setup and share all the details from our experience. We cover everything from gear, workflow, ways to deal with disruptions, and how to serve guests quickly and efficiently. This episode is packed with tips and tricks!Pick up our coffee here: https://mirrorcoffeeroasters.com/Find us on Instagram: https://www.instagram.com/mirrorcoffeeroasters/Mirror Coffee Roasters is a specialty coffee roaster located in Bellingham, WA

Dr. Saurabh Dahiya from Stanford University explains the recent changes in the FDA recommendations regarding the monitoring program previously mandated for centers delivering CAR-T therapies, and why this decision was celebrated by patients and their physicians.

The Social Contagion: Viral Ideologies & the Culture War for America's Future What happens when identity becomes ideology and information becomes a weapon?The Social Contagion: Viral Ideologies & The Culture War for America's Future is a fearless cultural deep-dive into the crisis of belief shaping American politics, media, and identity. With a journalist's clarity and a seeker's heart, Alison Sher dissects how social media, misinformation, and the viral spread of ideologies radicalized American culture during and after the COVID-19 pandemic.From conspiracy-laced echo chambers to digital activism gone extreme, Sher captures the raw tension of a nation split by culture wars, fighting a spiritual battle that transcends party lines. This isn't just another book on politics. It's an investigation into how the US lost the plot during the pandemic and how we might reclaim a shared narrative in an age of division.Through vulnerable storytelling, sharp media critique, and philosophical insight, The Social Contagion charts the conspiracy theories that shaped national conversation and the inner fractures that occur when truth becomes indiscernible and belonging is weaponized.For readers disillusioned by mainstream discourse, yet skeptical of easy answers, this book provides a map through our modern-day ideological and tribal maze.YOUR GUIDE THROUGH POST-TRUTH AMERICA☑ Decode the psychological mechanics of belief, influence, fear, and violence☑ Break out of groupthink and examine the cost of political polarization☑ Explore how media in America drives identity, division, and dissent☑ Understand the fallout of cancel culture and an information ecosystem that fosters mass distrust☑ A rare blend of investigative journalism, sociology, and philosophical reflectionWHY THIS BOOK STANDS APARTNot Left. Not Right. Just Real.Sher writes from outside the ideological trenches, challenging both woke politics and alt-right culture with compassion and clarity.The Story Behind the SpinThis is more than a conspiracy theory book. It's a humane look at why narratives go viral, and how misinformation and paranoia affect the soul of a nation.For the Politically HomelessIf you feel burned out, disillusioned, or intellectually orphaned since Trump's rise to power, this book meets you where you are, explains why so many Americans feel the same way, and charts a path forward.Emotionally Intelligent, Intellectually BravePerfect for readers who follow Bari Weiss, Jonathan Haidt, Glenn Greenwald, or anyone seeking to understand how the events of 2020 and beyond have shaped our current reality.Whether you're searching for answers to explain the results of the 2024 election or meaning in the chaos of a world at war, The Social Contagion is a bold, necessary read.Unplug from the noise. Unlearn the narratives. Rediscover what it means to think for yourself. Scroll up and click “Add to Cart” to begin.Want to be a guest on Book 101 Review? Send Daniel Lucas a message on PodMatch, here: https://www.podmatch.com/hostdetailpreview/17372807971394464fea5bae3 Hosted on Acast. See acast.com/privacy for more information.

On a Thursday edition of the Daily Clone, Jake Brend takes you through how Jon Heacock and the Iowa State defense are preparing for South Dakota with very little film. Matt Campbell talks about the impact of the 2000 team ahead of their return to Jack Trice Stadium. The helmet cart returns, a sneak peak into "The Beat Reporters," and more on a Thursday! Learn more about your ad choices. Visit megaphone.fm/adchoices

Small cell lung cancer was once considered one of the most challenging diagnoses in oncology. But today, groundbreaking treatments are transforming patient outcomes and rewriting survival stories. Discover how immunotherapy, T-cell engagers, CAR T-cell therapy, and antibody drug conjugates are moving from clinical trials to standard care, offering patients years of disease control and genuine hope for the future. Featuring insights from Dr. Jacob Sands, thoracic oncologist at Dana-Farber Cancer Institute, and inspiring patient advocate Wendy Brooks, who shares her powerful journey from early detection through cutting-edge clinical trials, proving that advocacy and hope can change everything. Guests: Dr. Jacob Sands, Oncologist, Dana-Farber Cancer Institute Courtney Mantz, Program Manager II, SCLC Program, Dr. Sands' Assistant. Dana-Farber Cancer Institute, Lowe Center for Thoracic Oncology Wendy Brooks, Patient Advocate Show Notes | Transcript | Watch Video

Angela Diffly, Director of Restaurant Digital and Technology Capabilities at Coca-Cola, talks restaurant tech trends and how the company is helping restaurants boost digital ordering and guest retention through smart partnerships. She also explores the future of instant delivery and where the digital dining experience is headed.

Blood Editor, Dr. Thomas Coates interviews Dr. Emanuele Angelucci on his paper, "How I manage iron overload in the hematopoietic cell transplantation setting" which is featured in Blood's "How I Treat Series on Iron Overload in Hematologic Disorders". See the full How I Treat series in volume 145 issue 4 of Blood. 

In this week's episode we'll learn about targeting NPM1 in acute myeloid leukemia. Researchers report the first clinical evidence of a menin inhibitor inducing complete remissions in AML with a NPM1 mutation. This validates NPM1 as a new therapeutic target in AML, alongside FLT3, IDH1/2, and KMT2A. Also on the podcast: targeting CD137 to prevent graft-versus-host disease. In nonhuman primates, a single dose of a CD137 antibody-drug conjugate provided long-term protection, with one important caveat: the potential for viral reactivation.Featured Articles: Menin inhibition with revumenib for NPM1-mutated relapsed or refractory acute myeloid leukemia: the AUGMENT-101 studyA single dose of a CD137 antibody–drug conjugate protects rhesus macaque allogeneic HCT recipients against acute GVHD

 Your grocery cart tells a story about your priorities, your season of life, and your health goals. I'm taking you inside my own cart, guilty pleasures and all, to show you how to shop for hormone health without giving up balance, joy, or flavor. Hey Hormone Hotties:If you want to learn more about how you can work with me or what services I offer including those below- https://linktr.ee/TheHappyHormonesCoach Interested in being a guest expert (even if you are not in business but a woman who has a story to share) fill out the application and book an appointment. Affiliated Partner for awesome products in wellness and more including the "Body balancing" slenderize for a discount using my code HAPPY24 Join me in Happy Hormones Circle. This and my email list is where I will be focusing my time and content Disclaimer: The content shared in ‘The Happy Hormones Coach' podcast (including affiliate and non affiliate products) is for informational purposes only and is not intended as medical advice, diagnosis, or treatment. Please consult with a qualified healthcare provider before making any changes to your diet, exercise, or health routine. The opinions expressed in this podcast are those of the host and guests and do not necessarily reflect the views of any healthcare organizations. The statements made regarding any of the products that I mention have not been evaluated by the Food and Drug Administration (FDA). Individual results may vary.

Host: Charles Turck, PharmD, BCPS, BCCCP Guest: Evandro Bezerra, MD As CAR T-cell therapy advances, so does the complexity of adverse event monitoring. Due to evolving insights into acute toxicities, infections, cytopenias, and secondary malignancies, both inpatient and outpatient care models are adapting to meet new standards. Joining Dr. Charles Turck to discuss practical strategies and emerging tools for managing post-CAR T toxicities across the continuum of care is Dr. Evandro Bezerra, Clinical Assistant Professor at Ohio State University Comprehensive Cancer Center in Columbus.

Avec : Fred Hermel, chroniqueur. Jean-Philippe Doux, journaliste et libraire. Et Carine Galli, journaliste. - Accompagnée de Charles Magnien et sa bande, Estelle Denis s'invite à la table des français pour traiter des sujets qui font leur quotidien. Société, conso, actualité, débats, coup de gueule, coups de cœurs… En simultané sur RMC Story.

In this episode of Lab Rats to Unicorns, John Flavin is joined by Jonathan Gluck—award-winning writer, longtime magazine editor, and now author of the deeply personal memoir An Exercise in Uncertainty: A Memoir of Illness and Hope. For more than two decades, Jonathan helped shape cultural conversations at New York Magazine, Vogue, The New York Times, and The Washington Post. But in his book, he turns the lens inward, chronicling his unexpected cancer diagnosis, the maze of the healthcare system, and the breakthroughs in biomedical research that helped him outlive the odds. From his first shocking diagnosis of multiple myeloma in his late thirties to the cutting-edge therapies like CAR T-cell treatment that have sustained him two decades later, Jonathan's journey reflects both the fragility and resilience of the human spirit. Along the way, he shares how writing helped him process uncertainty, why patient storytelling matters for science and society, and what lessons living “one stone at a time across the river” can offer to entrepreneurs, innovators, and anyone facing the unknown.

Os portugueses continuam a utilizar dinheiro físico mesmo após 40 anos de uso do multibanco e de uma década de MB Way. O papel-moeda acabará por se extinguir ou continuará a haver espaço para ambos?See omnystudio.com/listener for privacy information.

Chaque jour, retrouvez le journal de 19h de la rédaction d'Europe 1 pour faire le tour de l'actu. Hébergé par Audiomeans. Visitez audiomeans.fr/politique-de-confidentialite pour plus d'informations.

Chaque jour, retrouvez le journal de 19h de la rédaction d'Europe 1 pour faire le tour de l'actu. Hébergé par Audiomeans. Visitez audiomeans.fr/politique-de-confidentialite pour plus d'informations.

Now boarding: first class, for the third episode of Zouk's Cubes! Jason Mantzoukas returns for an ATC takeover. This time, Kulap is getting the deets on how SuChin and Jason pack for an international trip. Jason is fresh off ten days in the U.K., while SuChin is prepping for her family's trip to South Korea. It's Jason's jigsaw puzzle packing vs. SuChin's clear Ziploc bags. There will be finger shoving, tarp tucking, and plenty of cubes.  We want to hear from you! Drop us a message on Speakpipe. Subscribe to the Add to Cart newsletter for juicy extras. Please note, Add To Cart contains mature themes and may not be appropriate for all listeners.  To see all products mentioned in this episode, head to @addtocartpod on Instagram. To purchase any of the products, see below.  Missed our previous Zouk's Cubes episodes? Check out ep 1 and the live show!  Trip Tarp for the tarp tuckers out there  You can never have too many totes. Jason uses the Hyperlite Tote Bag and the Tom Bihn Zip-Top Shop Bag. He also likes packable totes from Peak Design, Matador and Bellroy.  Get into these Comrad compression socks on flights  A classic cube: The Evergoods 8L Transit Packing Cube. He also loves the compression cubes from Peak Design and Nomatic.  His packable clothesline is a paracord  Adam Savage from Mythbusters makes pouches! Jason travels with the Rimowa Cabin Plus suitcase  Zouks is the backpack king!  He likes The Tom Bihn Technonaut Backpack and Shadow Guide Backpack , as well as the Arc'teryx Konseal 15 backpack  He wears the Evergoods Civic Access Sling through TSA  What's in Jason's tech bag? The Epicka Universal Travel Adapter  Stay up to date with us on Twitter, Facebook, and Instagram at @LemonadaMedia.  Joining Lemonada Premium is a great way to support our show and get bonus content. Subscribe today at bit.ly/lemonadapremium.  Click this link for a list of current sponsors and discount codes for this show and all Lemonada shows: lemonadamedia.com/sponsorsSee omnystudio.com/listener for privacy information.

Send us a textAmazon's AI shopping assistant now tracks user preferences, past purchases, and product questions. This new tool reads reviews, compares products, and organizes results to guide shoppers. It may affect how listings rank, but sellers shouldn't change their Amazon SEO strategies just yet.Test if your Amazon listings are ready for AI-driven search, book a strategy call now: https://bit.ly/4jMZtxuGet instant FREE access to 300 proven Amazon tips and start solving problems faster today: https://bit.ly/4ft3s1w#AmazonAI #EcommerceTips #AmazonSellerAdvice #AmazonUpdates #amazonrufusWatch these videos on YouTube:Amazon PPC Tier List Management Rankings https://www.youtube.com/watch?v=m9s9vjtU5l4&list=PLDkvNlz8yl_a1PRDJWRoR4yIM8K5Ft569&utm_content=342357286&utm_medium=social&utm_source=youtube&hss_channel=ytc-UClUSEsDS2sdgNJfCcCM_5UwWhy Turning Off Ads Kills Sales and Rankings on Amazon: https://www.youtube.com/watch?v=fp5fCd0i7ts&list=PLDkvNlz8yl_a1PRDJWRoR4yIM8K5Ft569&index=2&utm_content=342357286&utm_medium=social&utm_source=youtube&hss_channel=ytc-UClUSEsDS2sdgNJfCcCM_5Uw-----------------------------------------------Tired of marketplace limits? Let's talk real growth with DTC strategy: https://bit.ly/4kOz6rrStop wasting ad spend. Grab the PPC guide that actually drives results: https://bit.ly/4lF0OYXRank higher and sell faster, get the SEO tools built for real growth: https://bit.ly/3JyMDGoBe ready before problems hit, download the kit every brand should have: https://bit.ly/4maWHn0Timestamps00:00 - Rufus Remembers Your Shopping History01:15 - Real Example: How Many Mice Have I Bought?02:00 - How Rufus Answers Product Questions03:15 - Asking Rufus for Product Recommendations04:30 - Comparison and Product Idea Tools05:30 - Order History Becomes Personalized Search06:30 - AI in Planning Events with Rufus07:30 - Rufus Misses Add-to-Cart on Desktop08:30 - Structured Output: Organized Shopping Help09:30 - Overhyped Features vs. Real Use10:30 - Should Amazon Sellers Worry About Rufus?----------------------------------------------Follow us:LinkedIn: https://hubs.ly/Q03ClQRm0Instagram: https://hubs.ly/Q03ClSmD0Pinterest: https://hubs.ly/Q03ClVJt0Twitter: https://hubs.ly/Q03ClRNd0Subscribe to the My Amazon Guy podcast: https://hubs.ly/Q03ClTjw0Apple Podcast: https://hubs.ly/Q03ClPSR0Spotify: https://hubs.ly/Q03ClLQ20Support the show

In today's episode, supported by Autolus, we spoke with Aaron Logan, MD, PhD, and Bijal Shah, MD, MS, about the evolving use of obecabtagene autoleucel (obe-cel; Aucatzyl) in the relapsed/refractory B-cell acute lymphoblastic leukemia (B-ALL) treatment paradigm. Dr Logan is an associate professor of clinical medicine in the Division of Hematology/Oncology at the University of California, San Francisco (UCSF) School of Medicine, as well as a member of the UCSF Helen Diller Family Comprehensive Cancer Center. Dr Shah is an associate member in the Department of Malignant Hematology at Moffitt Cancer Center in Tampa, Florida.  In our conversation, Drs Logan and Shah discussed where obe-cel currently fits into the B-ALL treatment paradigm, how the use of this agent might expand going forward, and what the future looks like for the broader CAR T-cell therapy development field in ALL. 

This month, the gals invite our wonderful Wisconsinite production manager, Andrea, to discuss flammable turkeys, rats under arrest, a drunken Dells disaster, mystery accents, unearthed urns, and a very creative way of identifying remains. Tune in for August's Gossip at the Corpse Cart! For a full list of show sponsors, visit https://wineandcrimepodcast.com/sponsors. To advertise on Wine & Crime, please email ad-sales@libsyn.com or go to advertising.libsyn.com/winecrime.

In this episode of the SRNA "Ask the Expert" podcast moderated by Dr. GG deFiebre, Dr. Kyle Blackburn and Dr. Benjamin Greenberg discussed the need for updated diagnostic criteria for myelitis. Dr. Blackburn explained the term myelitis and the importance of precise terminologies for accurate diagnoses and research [00:05:10]. Dr. Greenberg elaborated on the advancements in testing and understanding of associated disorders like NMOSD and MOGAD since 2002 [00:11:10]. Both experts stated that the shift from "transverse myelitis" to "myelitis" will aid future research, treatments, and patient care [00:17:27]. They reassured patients that these changes would essentially refine their care but not alter it dramatically [00:23:40]. They encouraged patients to stay informed and communicate with their healthcare providers about these updates [00:28:58].Kyle Blackburn, MD is an Assistant Professor in the Department of Neurology at UT Southwestern Medical Center in Dallas, Texas. He specializes in neuroimmunology and has clinical interests in antibody-mediated neurologic disorders, including autoimmune encephalitis, epilepsy, and ataxias; neurologic complications of cancers, including paraneoplastic disorders and checkpoint inhibitor/CAR T-cell toxicity; and demyelinating disorders, including sarcoidosis, neuromyelitis optica, myelin oligodendrocyte glycoprotein (MOG)-associated disease, and multiple sclerosis. Dr. Blackburn earned his medical degree at the University of Kentucky College of Medicine. He performed his residency in adult neurology at UT Southwestern, serving his final year as Chief Resident, and stayed to complete a fellowship in neuroimmunology, during which he earned the James T. Lubin Clinician Scientist Award from the Siegel Rare Neuroimmune Association (SRNA). He joined the UT Southwestern faculty in 2020.Benjamin M. Greenberg, M.D., M.H.S. is a Professor and the Cain Denius Scholar in Mobility Disorders in the Department of Neurology at UT Southwestern Medical Center in Dallas, Texas. He currently serves as the Vice Chair of Translational Research and Strategic Initiatives for the Department of Neurology. He is also the interim Director of the Multiple Sclerosis Center and the Director of the Neurosciences Clinical Research Center. In addition, he serves as Director of the Transverse Myelitis and Neuromyelitis Optica Program and the Pediatric Demyelinating Disease Program at Children's Medical Center.Dr. Greenberg earned his medical degree at Baylor College of Medicine before completing an internal medicine internship at Chicago's Rush Presbyterian-St. Luke's Medical Center. He performed his neurology residency at the Johns Hopkins School of Medicine. He also holds an M.H.S. in molecular microbiology and immunology from the Bloomberg School of Public Health, as well as a bachelor's degree in the history of medicine – both from Johns Hopkins. Prior to his recruitment to UT Southwestern in 2009, Dr. Greenberg was on the faculty of the Johns Hopkins Division of Neuroimmunology, serving as the Director of the Encephalitis Center and Co-Director of the nation's first dedicated Transverse Myelitis Center.Dr. Greenberg splits his clinical time between adult and pediatric patients at William P. Clements Jr. and Zale Lipshy University Hospitals, Parkland, and Children's Medical Center. His research focuses on better diagnosing, prognosticating, and treating demyelinating diseases and nervous system infections. He also coordinates clinical trials to evaluate new treatments to prevent neurologic damage and restore function to affected patients. 00:00 Introduction00:58 Overview of Myelitis and Diagnostic Criteria02:57 Historical Context and Importance of Updated Criteria05:10 Challenges with Current Terminology11:10 Changes in Understanding and Diagnostic Approaches17:27 Implications for Patients and Clinical Practice23:40 Impact on Research and Future Directions28:58 Patient Advocacy31:17 Conclusion

Update from the Menendez brothers' court case. Selane and Benny had their bachelor and bachelorette parties over the weekend. Mario Cart is now named the most stressful game of all time. Make sure to also keep up to date with ALL our podcasts we do below that have new episodes every week:The Thought ShowerLet's Get WeirdCrisis on Infinite Podcasts

In 2025, we attended the 19th International Congress of Immunology, hosted by the International Union of Immunological Societies, in Vienna, Austria, and recorded daily episodes discussing highlights of the conference. Here is the final of five special episodes from the meeting, in which Brenda and Jason discuss sessions on AI applications and CAR T therapy progress.

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Broadcast from KSQD, Santa Cruz on 8-21-2025: Dr. Dawn opens with disturbing research linking respiratory infections to breast cancer reactivation. Studies show increased breast cancer deaths during COVID beyond screening delays, suggesting viral infections may awaken dormant cancer cells through inflammatory signals. Mouse models demonstrate that influenza infection can increase metastatic burden up to 1000-fold by triggering neutrophil extracellular traps that act as growth signals for sleeping cancer cells. She covers neuroimmune crosstalk in lung fibrosis research, where mice lacking pain receptors developed worse scarring when exposed to lung injury. The absence of pain signals failed to trigger natural inflammation suppressors, leading to increased neutrophil activity and inflammatory nets that contributed to tissue damage. New food spoilage detection technology uses pH-sensitive dyes in packaging that fluoresce or change color when bacterial metabolism produces acids. This could prevent foodborne illness from contaminated deli meats and dairy products by providing visual warnings before consumption, particularly important for high-risk foods like lunch meats and mayonnaise. Dr. Dawn warns about diquat replacing glyphosate in Roundup products, potentially creating 200 times more toxicity. The new compound suppresses gut lining proteins, creating leaky gut and allowing bacterial toxins into the bloodstream, while causing permanent kidney, liver, and lung damage. Most countries have banned diquat, but it remains available in American stores. Research reveals that lactose intolerance can cause intense nightmares through gut-brain connections. Montreal studies found that people with dairy sensitivity experience more frequent, distressing dreams that improve significantly when dairy is eliminated from their diet. The mechanism likely involves gastrointestinal discomfort causing microarousals that make dreams more vivid and memorable. She describes revolutionary remote-controlled probiotics combining genetically modified E. coli with pill cameras. These bacterial robots can detect inflammation, produce therapeutic compounds on command, and communicate through bioluminescence. Applications include targeted inflammatory bowel disease treatment where bacteria manufacture anti-TNF nanobodies when activated by LED signals from swallowed capsules. An emailer with recurring diverticulitis asks about surgical options versus dietary management. Dr. Dawn explains the structural causes of diverticular disease and the vicious cycle created by repeated antibiotic treatments that damage gut microbiomes. She emphasizes the importance of dramatically increasing fiber intake and addressing underlying leaky gut issues that may contribute to the condition. A caller asks about foods for better bowel movements while managing diabetes and taking Wegovy. Dr. Dawn recommends ground flaxseed mixed into various foods and weekly preparation of roasted root vegetables for someone with limited cooking skills. The conversation becomes personal as the caller expresses concerns about housing security and healthcare access during uncertain political times. New microplastic research reveals how these particles accumulate bacteria, viruses, and toxins in biofilm "coronas" that enhance their harmful effects. Different plastic types carry varying electric charges affecting where they travel in the body. Breakthrough laser detection methods now allow precise identification and tracking of specific plastic polymers in tissues, enabling better research on health impacts. Dr. Dawn discusses advances in CAR-T cell therapy for multiple myeloma, sharing positive results from her husband's recent treatment. New research suggests injecting lipid nanoparticles containing CAR DNA instead of removing T-cells for laboratory modification, potentially making this therapy much cheaper and more accessible while maintaining effectiveness for blood cancers.

Jacob Kimmel thinks he can find the transcription factors to reverse aging. We do a deep dive on why this might be plausible and why evolution hasn't optimized for longevity. We also talk about why drug discovery has been getting exponentially harder, and what a new platform for biological understanding to speed up progress would look like. As a bonus, we get into the nitty gritty of gene delivery and Jacob's controversial takes on CAR-T cells. For full disclosure, I am an angel investor in NewLimit. This did not impact my decision to interview Jacob, nor the questions I asked him.

In this week's episode we'll learn about how by combining PET response with circulating tumor DNA, or  ctDNA, in newly treated patients with follicular lymphoma, investigators identify those patients likely to progress within 24 months of initial treatment, also known as POD24. After that: Immune hotspots in aplastic anemia. These newly identified hotspots potentially represent sites in the bone marrow where the active immune response takes place, driving the destruction of hematopoietic stem and progenitor cells. Finally, allogeneic transplantation for Hodgkin lymphoma in the checkpoint inhibitor era. In a large, retrospective study, patients with prior checkpoint inhibitor exposure had remarkable outcomes, particularly when post-transplant cyclophosphamide was used.Featured Articles: Combined PET and ctDNA response as predictors of POD24 for follicular lymphoma after first-line induction treatmentImaging Mass Cytometry Reveals the Order of Events in the Pathogenesis of Immune-Mediated Aplastic AnemiaOutcomes of Allogeneic HCT in Hodgkin Lymphoma in the Era of Checkpoint Inhibitors: A Joint CIBMTR and EBMT Analysis

John Deere is rolling out several updates to its harvest lineup for 2026, including new features for combines, grain carts, and flex drapers. At Ag in Motion, RealAgriculture caught up with Bergen Nelson, go-to-market lead for harvesting at John Deere, to learn more about what’s coming. For combines, Nelson highlights advances in predictive ground speed... Read More

Send us a textEnter the bizarre world of "War of the Worlds 2025," where product placement and alien invasion collide in what might be the most gloriously terrible sci-fi film of recent years. Join us as we unpack this Amazon Prime spectacle that had us laughing harder than any intentional comedy could.At the center of this disaster is Ice Cube as Will Radford, a government surveillance analyst who can hack into anything on Earth—except, apparently, the door keeping him trapped in his office during an alien invasion. While meteors rain down and tripods emerge from the ground, Will's primary concern remains spying on his pregnant daughter and gamer son, much to our bewilderment and amusement.The film reaches peak absurdity when Will needs to upload a virus to defeat the data-eating aliens (yes, they eat data), but can only receive the necessary thumb drive through an Amazon Prime Air delivery—which requires placing an actual Amazon order first "because protocol." When a homeless man is convinced to help the mission in exchange for an Amazon gift card, we knew we'd reached cinematic rock bottom.From Ice Cube's emotionless "oh" upon seeing his daughter's blood-soaked empty Tesla to the son's revelation as the mysterious hacker "The Disruptor," every scene delivers fresh waves of unintentional comedy. The climactic solution involving a "cannibal code" that makes the aliens consume themselves perfectly caps this monument to illogical storytelling.Whether you're a connoisseur of terrible cinema or simply need a good laugh, "War of the Worlds 2025" belongs in the hallowed halls of so-bad-it's-good classics. Have you experienced a movie so delightfully terrible it became entertainment gold? Share your thoughts in the comments!Written lovingly by AIBe our friend!Dan: @shakybaconTony: @tonydczechAnd follow the podcast on IG: @hatewatchingDAT

Il n'a pas laissé un grand nom dans l'Histoire ; et pourtant, c'est bien le Maréchal de Villeroy que Louis XIV avait désigné pour devenir le gouverneur de son trop jeune successeur… Mention légales : Vos données de connexion, dont votre adresse IP, sont traités par Radio Classique, responsable de traitement, sur la base de son intérêt légitime, par l'intermédiaire de son sous-traitant Ausha, à des fins de réalisation de statistiques agréées et de lutte contre la fraude. Ces données sont supprimées en temps réel pour la finalité statistique et sous cinq mois à compter de la collecte à des fins de lutte contre la fraude. Pour plus d'informations sur les traitements réalisés par Radio Classique et exercer vos droits, consultez notre Politique de confidentialité.Hébergé par Ausha. Visitez ausha.co/politique-de-confidentialite pour plus d'informations.

Ming-Wei Chen and Fangheng Zhou, the scientists behind RephImmune, join hosts Lynnsey and Matthew to discuss how their biotech startup is developing a next-generation cell therapy platform designed to overcome the limitations of CAR-T.  With a focus on ovarian cancer, RephImmune's RACE-T technology targets solid tumors by re-engineering immune cells to better locate, penetrate, and survive in the harsh tumor environment. Ming-Wei and Fangheng share their personal motivations, the science behind their approach, and how programs like SCbio DRIVE are helping them move closer to clinical trials. Tune in now!

In this week's episode, we'll learn more about how exogenous CD19 stimulation affects CAR T-cell persistence in B-cell acute lymphoblastic leukemia treated with CD19 CAR T-cell therapy; new algorithms that incorporate sequential rapid immune-assays, intended to improve diagnosis of heparin-induced thrombocytopenia, and resource-adaptive survival prediction models to help guide management of patients with chronic myelomonocytic leukemia.Featured Articles:Outcomes of PLAT-02 and PLAT-03: evaluating CD19 CAR T-cell therapy and CD19-expressing T-APC support in pediatric B-ALLSequential combinations of rapid immunoassays for prompt recognition of heparin-induced thrombocytopeniaBLAST: a globally applicable and molecularly versatile survival model for chronic myelomonocytic leukemia

In case you didn't know, John has an alter ego - John Flint Grocery Cart Cop - that finds perpetrators of the serious crime of not returning their cart. What we did not know is that this good deed can turn him into the athlete he was always meant to be. He just has to go to Germany first...

This week on Marketing O'Clock: Google adds a cart data diagnostics tool for spotting gaps in conversion reporting. Also, Bing Webmaster Tools gets a data boost, more filters, and trendlines that are playing hard to get. Plus, all of the digital marketing news you missed last week.Visit us at - https://marketingoclock.com/

La deuxième heure en intégralité de l'émission « Rothen s'enflamme », le rendez-vous qui vous plonge dans un vestiaire de foot. Tous les soirs, des anciens joueurs professionnels analysent et débattent autour de l'actualité du foot. Jérôme Rothen anime des

In a country that feels more divided than ever, there’s one thing almost everyone agrees on: our healthcare system is broken. From crushing medical debt to rural hospital closures, deep Medicaid cuts, and the growing burden of insurance denials, too many Americans are falling through the cracks. In Uncared For, award-winning journalist SuChin Pak (Add to Cart, MTV News) investigates the personal and political forces behind our fractured system. This season, the show zooms out to examine the healthcare system as a whole. Through deeply personal stories and expert insight, Uncared For uncovers why so many people feel, quite literally, uncared for — and what it would take to build something better. After you listen to this preview, search for Uncared For in your podcast app to hear the rest of the series, or head to https://lemonada.lnk.to/UncaredForSeason3fd.See omnystudio.com/listener for privacy information.

In a country that feels more divided than ever, there’s one thing almost everyone agrees on: our healthcare system is broken. From crushing medical debt to rural hospital closures, deep Medicaid cuts, and the growing burden of insurance denials, too many Americans are falling through the cracks. In Uncared For, award-winning journalist SuChin Pak (Add to Cart, MTV News) investigates the personal and political forces behind our fractured system. This season, the show zooms out to examine the healthcare system as a whole. Through deeply personal stories and expert insight, Uncared For uncovers why so many people feel, quite literally, uncared for — and what it would take to build something better. After you listen to this preview, search for Uncared For in your podcast app to hear the rest of the series, or head to https://lemonada.lnk.to/UncaredForSeason3fdSee omnystudio.com/listener for privacy information.

In a country that feels more divided than ever, there’s one thing almost everyone agrees on: our healthcare system is broken. From crushing medical debt to rural hospital closures, deep Medicaid cuts, and the growing burden of insurance denials, too many Americans are falling through the cracks. In Uncared For, award-winning journalist SuChin Pak (Add to Cart, MTV News) investigates the personal and political forces behind our fractured system. This season, the show zooms out to examine the healthcare system as a whole. Through deeply personal stories and expert insight, Uncared For uncovers why so many people feel, quite literally, uncared for — and what it would take to build something better. After you listen to this preview, search for Uncared For in your podcast app to hear the rest of the series, or head to https://lemonada.lnk.to/UncaredForSeason3fdSee omnystudio.com/listener for privacy information.

This week's Bonus Bang is the fourth in our "I Love Lily" series titled "Love, Bridge". Award nominated actor Jack Quaid joins Scott to talk about his animated character from Star Trek: Lower Decks being live action in the new season of Star Trek: Strange New Worlds, how a Facebook video he made at 15 appeared in a Scream movie, and the Transformers universe. Then, author Bridget Jones returns to read new entries from her diary. Later, TV host The Crypt Keeper stops by to talk about his audition for Tales from the Crypt. Plus, the ghost of musician Dr. John returns in search of a lawyer for a big case. (Originally released as episode #816 on 6/11/2023) Get access to all the podcasts you love, music channels and radio shows with the SiriusXM App! Get 3 months free using this show link: https://siriusxm.com/cbb

This month, the gals toast with recovering sommelier Ashwin Muthiah, founder of unPINNED, to unpack the benefits of long arms, weaponizing raccoons, bleeding orifices, mirrored elevators, shield maiden aspirations, and a very unsettling boil advisory. Tune in to July's episode of Gossip at the Corpse Cart! For a full list of show sponsors, visit https://wineandcrimepodcast.com/sponsors. To advertise on Wine & Crime, please email ad-sales@libsyn.com or go to advertising.libsyn.com/winecrime.