Podcasts about differentiated

A guide to diagnosing, imaging, and managing acute renal colic and nephrolithiasis in the ED. Hosts: Brian Gilberti, MD Avir Mitra, MD https://media.blubrry.com/coreem/content.blubrry.com/coreem/Nephrolithiasis.mp3 Download Leave a Comment Tags: Kidney Stones, Urology Show Notes 1. CLINICAL CORE & PHYSIOLOGIC FRAMEWORK Epidemiologic Risk Profiles Lifetime incidence parameters hover around 1 in 11, presenting with a prominent male sex skew. Peak demographic manifestation concentrated within the 30–60 age band. High-yield temporal parameter: 50% recurrence vector within a 5-year post-initial-insult window. Mineralogical Composition Vectors Calcium oxalate crystals represent the predominant structural matrix. Struvite configurations (magnesium ammonium phosphate matrix) account for 1–2% of cohorts. Struvite stones function explicitly as infection-driven configurations secondary to upper tract proliferation; higher distribution index noted in female cohorts. Etiological & Modifiable Relational Dynamics Profound systemic dehydration or low baseline fluid throughput states. High-sodium diet structures and heavy animal-protein consumption loads. Positive genetic/familial history variables. Relative risk modulation: Each variable independently operates to expand baseline risk by a factor of 2x to 3x. Pathophysiologic Symptom Complexes Acute, sudden-onset, maximum-intensity (10/10) unilateral flank pain. Classic structural radiation vector tracking downward toward the ipsilateral groin/genitourinary dermatomes. Distinctive behavioral marker: Renal colic pacing/writhing behavior with zero antalgic position availability. Concomitant autonomic triggers: Nausea and emesis manifest in 50% of acute presentations. Physical Exam Discordance Metrics Severe subjective distress contrasted with a characteristically soft, completely non-tender abdominal palpation exam. CVA tenderness is completely variable and lacks reliable negative predictive value. Atypical Presentation Classifications Vague, poorly localized abdominal pain presentations occurring in up to 20% of active cases. Isolated lower urinary tract irritative signs including acute frequency or severe urgency. Incidental & Asymptomatic Dynamics Silent intrarenal or ureteral stones found incidentally. Longitudinal tracking demonstrates up to 33.3% of initially asymptomatic cohorts convert to fully symptomatic renal colic within a multi-year tracking window. 2. EXCLUSION DIAGNOSES & CRITICAL PATHWAY RED FLAGS Vascular Mimics: AAA rupture/expansion. This is a mandatory exclusion pathway in elderly cohorts presenting with acute flank or back pain. Physical tracking requires active exploration for an expansile, pulsatile abdominal mass. Gynecologic Emergencies: Ruptured ectopic pregnancy. Demands universal screening protocols via rapid beta-hCG testing in all female patients of childbearing potential presenting with lower abdominal/pelvic localization. Infectious Upper Tract Decompensation: Acute uncomplicated pyelonephritis. Differentiated via persistent high spikes, high fevers, systemic shaking chills, and profound pyuria. Genitourinary Structural Crises: Acute testicular torsion. Mandates a thorough, explicit scrotal/testicular structural exam if the flank pain radiates into the scrotum. Gastrointestinal and Adnexal Torsional Confounds: Acute appendicitis variants, acute mesenteric/bowel ischemia, and ovarian torsion syndromes. 3. LABORATORY TESTING & PHYSIOLOGIC EVALUATION Urinalysis Interpretation Nuances Microscopic or gross hematuria presents in approximately 66% to 90% of acute cases. Critical Pathological Caveat: Complete absence of hematuria documented in 20% to 33.3% of confirmed, acute obstructing ureteral stones. Diagnostic rule: A pristine urinalysis with zero red blood cells is entirely insufficient to exclude acute ureterolithiasis. Urinary pH as a Composition Clue Consistently low urinary pH parameters (pH < 5.5) point strongly toward a uric acid crystalline composition. Elevated urinary pH parameters (pH > 7.5) indicate the presence of urease-producing microbial pathogens, pointing toward a struvite infection stone. Infectious Screening Metrics Active tracking for marked pyuria, positive leukocyte esterase, and bacterial nitrites to rule out an obstructed, infected upper urinary tract system. BMP Immediate quantification of baseline serum creatinine to establish accurate eGFR values. Targeting detection of post-renal AKI from bilateral obstruction, unilateral obstruction in a single functioning kidney, or severe volume depletion. CBC Evaluation for marked leukocytosis. Physiologic Nuance: Mild-to-moderate white blood cell count elevations frequently represent non-specific stress demargination driven by severe pain and repetitive vomiting. High-grade white blood cell shifts demand immediate exclusion of systemic bacteremia or an infected, obstructed urinary system. Adjunctive Lab Pathways Rapid qualitative urine hCG testing. Reflex urine culture execution whenever urinalysis metrics display significant inflammatory profiles or clinical suspicion of UTI is high. 4. IMAGING MODALITIES & ALGORITHMIC CLINICAL SELECTION Non-Contrast CT Diagnostics Gold standard; diagnostic sensitivity and specificity parameters exceed 95% for stones >2 mm. Provides precise quantification of stone diameter (mm), exact localization (proximal, mid, or distal ureter), and degree of secondary hydronephrosis. Excellent structural visualization for detecting or ruling out alternate retroperitoneal, vascular, or intra-abdominal pathologies. Contrast-Enhanced CT Protocols Indicated when alternative intra-abdominal surgical pathology is highly suspected over isolated renal colic. Retains diagnostic capability to identify urinary tract stones >3 mm even within contrast-enhanced phases. NCCT Structural Architecture Limitations Standard stone protocol CT scans are executed in a prone position without IV contrast enhancement. It does not opacify the ureteral lumen. Presents a cumulative radiation exposure penalty when utilized serially across recurrent ED presentations. POCUS / Radiology Ultrasound Direct stone visualization capabilities are modest, operating at approximately 50% to 60% sensitivity, and is highly dependent on anatomical positioning at the extreme proximal ureter or the UVJ. Secondary obstruction tracking: Demonstration of hydronephrosis operates at a high sensitivity of approximately 80%. POCUS Clinical Utility Metrics Eliminates ionizing radiation exposure and allows immediate, rapid real-time execution directly at the patient’s bedside. Confirmation of significant hydronephrosis within a classic clinical presentation yields high post-test probability for stone presence while lowering suspicion for vascular catastrophes like a AAA. KUB Radiography Extremely poor overall diagnostic sensitivity, hovering around 57%. Fails to image radiolucent configurations (pure uric acid matrices) or small stones measuring

Full episode here Most reps fire off bloated cold emails that bury the lead and pitch features instead of attacking real business problems. In this episode, Jason Bay breaks down:

In this week's episode of Slappin' Glass, we're joined by coach developer and researcher Dan Clements for a conversation on building environments where players are motivated to learn, compete, and keep coming back.The discussion starts with the difference between mastery-based and performance-based environments, and why the best coaches are able to chase results without letting every practice, conversation, and piece of feedback become purely outcome-driven. Clements details how voice, choice, task design, and differentiation can help players feel more invested in their own development, while still operating inside the demands of high-performance sport.From there, the conversation moves into one of the harder parts of coaching: knowing when to intervene. Clements shares why coaches often misremember what actually happened in a session, how staff reflection can sharpen future practices, and why the best feedback compares a player to themselves, not to the person next to them.The episode also explores strength-based coaching, the difference between honest positivity and toxic positivity, and why leaders don't give away control as much as they “lend power” through clear values, routines, and player ownership.This week's Start, Sub, or Sit focuses on motivation, with Clements choosing between autonomy, competence, and relatedness, and offering practical thoughts on helping struggling players regain confidence through better task design, developmental feedback, and small wins.What You'll Learn Why mastery-based environments can still exist inside performance-driven programs.  How voice and choice increase player investment without removing structure.  What differentiated coaching looks like inside a live practice.  How to know when to intervene, coach on the fly, or simply observe.  Why coaches often misremember their own practices.  How better reflection can improve staff development and practice design.  Why feedback should compare a player to themselves, not someone else.  How to coach from strengths without slipping into toxic positivity.  Why autonomy is more about “lending power” than giving up control.  How task design and developmental feedback can help struggling players regain confidence. Top Moments02:00 — Mastery vs. performance environments Clements explains how coaches can build environments that support long-term development without ignoring the pressure to win.03:17 — Voice, choice, and player investment A practical look at how giving players some ownership inside a session can increase motivation and commitment.04:25 — Differentiated coaching in practice Clements breaks down how one task can serve different players through roles, observation, and specific feedback.06:01 — The art of intervention A sharp section on when to stop a drill, when to coach on the fly, and how coaches can study their own feedback habits.07:33 — Reflective practice for coaches Clements outlines how coaches can review sessions through intended outcomes, actual outcomes, and useful next adjustments.10:59 — The TARGET framework A deeper look at task design, grouping, feedback, player voice, and time as levers for building a mastery climate.16:05 — Strength-based coaching without toxic positivity Clements explains how coaches can be honest, demanding, and direct while still building from what players do well.21:04 — “Lending power” as a head coach One of the best leadership ideas in the episode: autonomy does not mean giving up authority.26:50 — Start, Sub, or Sit: Motivation Clements ranks autonomy, relatedness, and competence as drivers of player motivation.31:11 — Helping struggling players regain confidence A practical section on stretch zones, task design, developmental feedback, and creating small wins.33:29 — The best investment: curiosity Clements closes with a strong thought on looking outside your own sport and holding your beliefs lightly enough to keep growing.To join coaches and championship winning staffs from the NBA to High School from over 70 different countries taking advantage of an SG Plus membership, visit HERE!

This week on Swimming with Allocators, growth-investor-turned-LP Yuri Lee (TMRS) joins Earnest and Alexa and explains how her global upbringing and love of technology shaped her investing philosophy and belief that talent can come from anywhere. She walks through TMRS's $3B and growing venture/growth mandate, how they split exposure between early-stage and multi-stage funds, and why they are building an aggressive 50/50 funds and co-investment program. Yuri shares what she looks for in emerging managers in clear, differentiated edge in sourcing, picking, or winning; true product–market fit between a manager's edge and fund strategy; and non-consensus, outlier ideas. Throughout, she offers candid advice on how GPs can better pitch institutional LPs, why most decks sound the same, and what it really takes to stand out in a consensus-heavy, AI-dominated market. Also, Chuck Daly of Sidley talks about how emerging VC managers should think proactively about compliance, conflicts of interest, disclosure, and performance/marketing practices under (and aligned with) the Advisers Act and SEC's marketing rule principles. Highlights from this week's conversation include: How a Global Upbringing Shapes an Investor's Worldview (0:13) Consumer Investing and Game Development Experience (2:22) Market Cycles in SaaS and Consumer Narratives (4:19) TMRS Mandate and Building a New Venture Program (6:16) Early Stage Managers and Differentiated, Non-Consensus Portfolios (9:20) What Matters Most at Early Stage vs Growth Stage (12:08) What LPs Really Want to Hear About: Companies and Decisions (14:11) How Pensions and Institutional LPs Run Diligence (17:04) Managing Portfolio Company Synergies and Conflicts (23:56) Marketing Rule Principles, Performance, and Case Studies (26:21) Why TMRS Uses Co-Invests and Target Mix With Funds (30:15) Barbell Approach: Early Stage Funds and Later Stage Co Invests (32:02) Information Gaps for LPs vs GPs and Founder Access (35:55) Consensus Rounds, Party Rounds, and Manager Profiles (38:56) Role of Non-Consensus Managers and Unique Edges (42:09) Rethinking AI Thesis and Value Capture by Model Labs (43:22) Advice For GPs Moving to LP Roles and Building Empathy (45:20) Final Thoughts and Takeaways (47:18) The Texas Municipal Retirement System is a $48+ billion public pension plan serving employees of participating Texas cities. TMRS invests across a diversified portfolio including public equities, fixed income, real assets, and private equity, with venture and growth investments forming an important component of its private markets strategy. Sidley Austin LLP is a premier global law firm with a dedicated Venture Funds practice, advising top venture capital firms, institutional investors, and private equity sponsors on fund formation, investment structuring, and regulatory compliance. With deep expertise across private markets, Sidley provides strategic legal counsel to help funds scale effectively. Learn more at sidley.com. Swimming with Allocators is a podcast that dives into the intriguing world of Venture Capital from an LP (Limited Partner) perspective. Hosts Alexa Binns and Earnest Sweat are seasoned professionals who have donned various hats in the VC ecosystem. Each episode, we explore where the future opportunities lie in the VC landscape with insights from top LPs on their investment strategies and industry experts shedding light on emerging trends and technologies.  The information provided on this podcast does not, and is not intended to, constitute legal advice; instead, all information, content, and materials available on this podcast are for general informational purposes only. Learn more about your ad choices. Visit megaphone.fm/adchoices

Matt Zeigler and Jack Forehand look at what recent Intentional Investor conversations can teach us about creativity, investing, YouTube, AI, mentorship and building a media business.Using clips from Michael Perry, Marc Rubinstein and Mat Cashman, they explore why knowing your limits, understanding your strengths, learning from mentors and building real relationships still matter in a world of algorithms and LLMs.Main topics covered:• Why personal stories reveal how investors and creators actually think• Michael Perry on accepting ceilings and learning from people you may never catch• What YouTube creators can learn from studying bigger platforms without copying them• Why different shows and platforms require different strategies• Marc Rubinstein on being a slow, methodical thinker and finding the right role• Shared values and complementary skills in creative partnerships• How Substack, YouTube, Twitter and audio platforms each serve different audiences• Why attention is the scarce resource in modern media• Mat Cashman on learning options from a real-world mentor on the CBOE floor• How AI and LLMs can become virtual mentors and strategy partners• Why relationships, trust and networks remain the edge technology cannot replaceTimestamps:00:00 What Intentional Investor can teach Just Press Record and Excess Returns03:32 Why personal stories matter in finance and investing conversations06:35 Michael Perry on ceilings, competition and accepting limits09:17 Learning from bigger creators without trying to become them13:40 Marc Rubinstein on slow thinking, research and knowing your strengths15:54 Shared values, complementary skills and creative collaboration18:21 Push and pull decisions, networking and building credibility over time19:56 Different strategies for YouTube, Substack, Twitter and audio21:05 Differentiated and discoverable content23:00 Why five lessons posts resonate with guests and audiences23:59 Attention as the scarce resource in the clip economy26:10 Mat Cashman on learning options from Lanny on the CBOE floor30:18 Direct mentors, indirect mentors and learning from the internet32:03 How AI and LLMs change the learning curve33:26 Why curiosity and hard work still create an edge35:08 Leaning into AI before it becomes table stakes36:20 Networks, relationships and the human edge that will not go away38:13 Closing thoughts and disclosures

Today’s headline news for Canadian IT solution providers: Dell’s ‘Modern Partner Platform’ brings AI directly to deal registration: Launching in the second half of the year, this unified portal introduces an “agentic partner experience.” Powered by a family of AI assistants, the platform connects demand signals, sales collaboration, deal registration, and pricing into a single interface. The impact on velocity: The new platform promises to reduce deal registration approvals from days to just “minutes.” It also features dynamic, real-time pricing—meaning partners can generate competitive, account-specific quotes without the friction of endless email loops with a Dell rep. AI matchmaking: Dell is using AI to analyze partner install bases and proactively surface cross-sell opportunities. In FY26 alone, Dell pushed more than 200,000 of these “demand signals” to its channel partners. Incentivizing a $6.1 trillion addressable market: Dell’s programmatic changes go live in August, aimed at helping partners capture an enterprise IT market where more than $4 trillion is delivered through the channel. Focus Accounts incentive: In a massive win for the platform MSP model, Dell is finally building a structured incentive that rewards partners for line-of-business expansion (e.g., cross-selling storage to a client device customer) rather than strictly prioritizing net-new logos. Differentiated base rebates: Partners will earn a premium rebate when selling strategic solutions. Dell explicitly named Dell Private Cloud, Dell Automation Platform, Cyber Resilience solutions, PowerStore, Z-Series networking, and premium Client+ products as the qualifiers. Advisory and SI recognition: Dell is formalizing a co-sell track that recognizes the influence of systems integrators and advisory partners who architect complex cloud and AI solutions, decoupling their reward from the ultimate hardware transaction. The ‘DeskSide Agentic AI’ sandbox tackles spiraling token costs: On the product side, Dell announced a massive expansion of the Dell AI Factory with NVIDIA, creating an on-premise development environment aimed at organizations suffering from public cloud API sticker shock. The economics of local AI: Built using NVIDIA NIM, OpenShift, and Dell Precision workstations, this secure sandbox allows developers to build and test AI agents locally. Dell claims this setup can reduce token spend by up to 87 percent compared to the public cloud, offering an ROI break-even point in as little as three months. Ecosystem expansion: Dell is also officially weaving Hugging Face, Mistral, xAI, Palantir, and ServiceNow natively into its validated AI ecosystem. PowerRack standardizes AI infrastructure: To help partners deploy complex AI infrastructure faster, Dell introduced a new turnkey, rack-scale solution for compute, networking, and storage. Speed to value: Designed for extreme rapid deployment, PowerRack allows partners to go from delivery on the loading dock to running live customer workloads in just six and a half hours. Read Full Transcript Hello and welcome to a special mid-day Holiday Monday episode of The Buzz from ChannelBuzz.ca. I’m Robert Dutt, and today is Monday, May 18, 2026. While you’re all hopefully back home enjoying Victoria Day, I’m here live from Dell Technologies World in Las Vegas, where Dell has announced a major overhaul of its partner experience, betting heavily that AI and new incentive structures will remove friction for the channel. The centerpiece is what Dell is calling its “Modern Partner Platform,” scheduled to roll out in the second half of the year. Chief Partner Officer Denise Millard says the platform is designed to connect demand signals, sales collaboration, deal registration, and pricing into a single hub. It delivers an “agentic partner experience,” relying on a new family of AI assistants to guide partners through quoting and post-order support. Critically for velocity, Dell promises this new platform will enable automated deal registration with approvals in minutes, alongside dynamic, real-time pricing that reduces the need for partner reps to negotiate via email. The platform will also proactively surface “demand signals,” using AI to analyze a partner’s install base and suggest perfectly timed cross-sell opportunities. On the programmatic side, Dell is launching new incentives in August that align directly with the platform MSP model. A new Focus Accounts incentive will reward partners for line-of-business expansion within existing accounts, rather than strictly prioritizing net-new logos. Also, Dell is formalizing a co-sell track that rewards systems integrators and advisory partners who architect complex AI and cloud solutions, decoupling influence from the ultimate transaction. Partners will also see a new differentiated base rebate targeting strategic solutions like Dell Private Cloud, PowerStore, and Cyber Resilience products. While the partner program announcements focus on how the channel goes to market, Dell’s Day 1 product announcements focus on what they are selling, highlighted by a massive expansion of the Dell AI Factory with NVIDIA. For the channel, the most actionable announcement is the introduction of a new “DeskSide Agentic AI” sandbox. Recognizing that public cloud API costs are spiraling out of control for developers building AI agents, Dell has created an on-premise, secure sandbox utilizing NVIDIA NIM, OpenShift, and Dell Precision workstations. Dell claims this local development environment can reduce token spend by up to 87 percent compared to public cloud alternatives, offering a break-even point in as little as three months. Dell is also formalizing the Dell AI Ecosystem, bringing validated solutions from players like Hugging Face, Mistral, xAI, Palantir, and ServiceNow natively into the fold. To support these massive AI workloads, Dell introduced PowerRack, a new turnkey, rack-scale solution encompassing compute, networking, and storage. Designed for rapid deployment, PowerRack can go from delivery to running live workloads in just six and a half hours, giving partners a highly standardized, rapidly deployable AI infrastructure offering. There’s more information on all of these announcement in the show notes or the blog post for this episode, and stay tuned to the site and the podcast all week for full coverage and interviews from Dell Technologies World. And if you’re a Canadian partner on-hand here in Vegas this week, drop me a note, I’d love to have a chat. That’s how we’re seeing the headlines today. I’m Robert Dutt for ChannelBuzz.ca, thanks for listening. Have a great Victoria Day.

Based on long-term results, “the effectiveness of that nanosecond pulse electric field begins to look as if it is a step function ahead of first generation PFA,” Pulse Biosciences CEO Paul LaViolette says, referring to the next stage of pulsed-field ablation innovation. In this Vanguards of Healthcare episode, LaViolette sits down with BI analyst Matt Henriksson for an in-depth interview about the potential benefits of nanosecond ablation technology to treat atrial fibrillation, which combines an ultrashort pulse duration with a high amplitude of voltage. LaViolette also discusses the commercial strategy behind the launch of its NANOPULSE-AF IDE pivotal study, following promising first-in-human trial results.See omnystudio.com/listener for privacy information.

What are the experts saying about thyroid cancer treatment in 2025?  Maybe it's time to discuss deescalation of aggressive surgical care for lower risk thyroid cancers.  We can accept that less surgery may be appropriate in select cases, including more thyroid lobectomies versus total thyroidectomies, consider less invasive approaches such as percutaneous ablation techniques, and utilize more observation with active surveillance.  Early assessment of treatment may allow appropriate reduction in use of radioactive iodine ablation and more relaxed routine monitoring can reduce surveillance burden to patients and providers. Hosts:  - Amanda Doubleday, DO, MBA, Assistant Professor, Waukesha Surgical Specialists, ProHealth Care.  Affiliated with University of Wisconsin School of Medicine and Public Health, Department of Surgery.  - Simon Holoubek, DO, MPH, Assistant Professor, University of Wisconsin School of Medicine and Public Health, Department of Surgery.  - Alexander Chiu, MD, Assistant Professor, University of Wisconsin School of Medicine and Public Health, Department of Surgery.  - Rebecca S Sippel, MD, FACS, Professor and Chair of Division of Endocrine Surgery, Vice Chair of Academic Affairs and Professional Development, University of Wisconsin School of Medicine and Public Health, Department of Surgery.  Learning Objectives:- Risk stratification system now includes 4 categories: low, low-intermediate, high-intermediate, and high-TSH suppression targets are simplified:  below the normal range if there is structural or biochemical disease and in the normal range if disease free. - Thyroid lobectomy is recommended for tumors < 2cm cT1N0 tumors and can be considered for tumors 2-4 cm. - Micro-Papillary Thyroid Carcinoma (

Andy Baskin and Dan Menningen reviews Todd Monken's perspective on determining a starting quarterback early to establish team rhythm. They also discuss Deshaun Watson's development, the nature of sports reporting, and the significance of national college decision day for families. 01:04 - Todd Monken Quarterback Philosophy 06:01 - Coaching Deshaun Watson 12:11 - College Decision Day

This wonderful conversation is one of the amazing panel discussions from the 2025 Neurodiverse Love Conference. The panelists are:- Daniel Dashnaw (danieldashnaw@hushmail.com or danieldashnawcouplestherapy.com)- Jill Corvelli (jill@jillcorvelli.com or ndpartnersinstitute.com)- Barbara Grant (bg-hc.com)- Jessie Mahoney (jessie@jessiemahoneymd.com or pauseandpresence.com)The topics discussed include the following:- What do therapists and coaches working with Neurodiverse couples need to know?- Differentiated dialogue - Nervous system regulation- Understanding and Working on rejection sensitivity dysphoria (RSD).- How to motivate a partner to begin individual or couples therapy.- The importance and value of a curiosity mindset.- Setting boundaries using B.I.F.F. communication (brief, informative, friendly, but firm).- Communicate what you're saying yes to, not just what you don't want.- Both partners share the responsibility for the “air space” in the relationship.- Paragraphing- What would love/respect do?- Lean into hope and decide what your intention is in the relationship.- Understanding that your nervous system may need some care and recovery.If you would like to get unlimited access to all the video recordings from the 2025 Neurodiverse Love Conference please click here and use code Podcast50 to get $50 off the price of the conference videos.When you buy access to the 2025 Neurodiverse Love Conference videos you will also receive a code to get 3 FREE bonuses: unlimited access to the videos from the 2023 Neurodiverse Love Conference sessions, the digital version of the Neurodiverse Love Conversation Cards and Neurodiverse Love Conversation Card Workbook.

In this episode of Better Edge, Northwestern Medicine Endocrinologist Ioannis Papagiannis, MD, reviews key updates from the 2025 American Thyroid Association Differentiated Thyroid Cancer Guidelines. He highlights refined, pathology specific risk stratification and a growing emphasis on individualized care. The discussion explores treatment de-escalation strategies, including active surveillance, surgical decision making, selective radioactive iodine use and tailored follow up, all designed to improve outcomes while minimizing overtreatment.

This content has been developed for healthcare professionals only. Patients who seek health information should consult with their physician or relevant patient advocacy groups.For the full presentation, downloadable Practice Aids, slides, and complete CME/MOC/NCPD/CPE/AAPA/IPCE information, and to apply for credit, please visit us at PeerView.com/BRB865. CME/MOC/NCPD/CPE/AAPA/IPCE credit will be available until March 26, 2027.Raising the Bar for Survival in High-Risk HR+, HER2- EBC: A Practical Framework for the Adjuvant Setting; Real-World Strategies to Improve Risk Assessment, Candidate Identification, Differentiated CDK4/6i + ET Selection, and Optimal Treatment Delivery In support of improving patient care, PVI, PeerView Institute for Medical Education, is jointly accredited by the Accreditation Council for Continuing Medical Education (ACCME), the Accreditation Council for Pharmacy Education (ACPE), and the American Nurses Credentialing Center (ANCC), to provide continuing education for the healthcare team.SupportThis activity is supported by an educational grant from Lilly.Disclosure information is available at the beginning of the video presentation.

This content has been developed for healthcare professionals only. Patients who seek health information should consult with their physician or relevant patient advocacy groups.For the full presentation, downloadable Practice Aids, slides, and complete CME/MOC/NCPD/CPE/AAPA/IPCE information, and to apply for credit, please visit us at PeerView.com/BRB865. CME/MOC/NCPD/CPE/AAPA/IPCE credit will be available until March 26, 2027.Raising the Bar for Survival in High-Risk HR+, HER2- EBC: A Practical Framework for the Adjuvant Setting; Real-World Strategies to Improve Risk Assessment, Candidate Identification, Differentiated CDK4/6i + ET Selection, and Optimal Treatment Delivery In support of improving patient care, PVI, PeerView Institute for Medical Education, is jointly accredited by the Accreditation Council for Continuing Medical Education (ACCME), the Accreditation Council for Pharmacy Education (ACPE), and the American Nurses Credentialing Center (ANCC), to provide continuing education for the healthcare team.SupportThis activity is supported by an educational grant from Lilly.Disclosure information is available at the beginning of the video presentation.

This content has been developed for healthcare professionals only. Patients who seek health information should consult with their physician or relevant patient advocacy groups.For the full presentation, downloadable Practice Aids, slides, and complete CME/MOC/NCPD/CPE/AAPA/IPCE information, and to apply for credit, please visit us at PeerView.com/BRB865. CME/MOC/NCPD/CPE/AAPA/IPCE credit will be available until March 26, 2027.Raising the Bar for Survival in High-Risk HR+, HER2- EBC: A Practical Framework for the Adjuvant Setting; Real-World Strategies to Improve Risk Assessment, Candidate Identification, Differentiated CDK4/6i + ET Selection, and Optimal Treatment Delivery In support of improving patient care, PVI, PeerView Institute for Medical Education, is jointly accredited by the Accreditation Council for Continuing Medical Education (ACCME), the Accreditation Council for Pharmacy Education (ACPE), and the American Nurses Credentialing Center (ANCC), to provide continuing education for the healthcare team.SupportThis activity is supported by an educational grant from Lilly.Disclosure information is available at the beginning of the video presentation.

This content has been developed for healthcare professionals only. Patients who seek health information should consult with their physician or relevant patient advocacy groups.For the full presentation, downloadable Practice Aids, slides, and complete CME/MOC/NCPD/CPE/AAPA/IPCE information, and to apply for credit, please visit us at PeerView.com/BRB865. CME/MOC/NCPD/CPE/AAPA/IPCE credit will be available until March 26, 2027.Raising the Bar for Survival in High-Risk HR+, HER2- EBC: A Practical Framework for the Adjuvant Setting; Real-World Strategies to Improve Risk Assessment, Candidate Identification, Differentiated CDK4/6i + ET Selection, and Optimal Treatment Delivery In support of improving patient care, PVI, PeerView Institute for Medical Education, is jointly accredited by the Accreditation Council for Continuing Medical Education (ACCME), the Accreditation Council for Pharmacy Education (ACPE), and the American Nurses Credentialing Center (ANCC), to provide continuing education for the healthcare team.SupportThis activity is supported by an educational grant from Lilly.Disclosure information is available at the beginning of the video presentation.

In today's episode, I explore why differentiated value is the most important—and most misunderstood—part of positioning. I explain why customers don't really care that much about features, how to use the “so what?” question to uncover what truly matters, and why this step takes more time than any other in a positioning exercise. I also share how my thinking on value has evolved since the first edition of my book, Obviously Awesome, and why I expanded this section so much in the second edition.You will learn: (03:14) How skipping competitive alternatives and capabilities leads to opinion-based positioning.(04:38) Why differentiated value is about outcomes, not feature checklists.(06:15) How to use repeated “so what?” questions to move from features to real value.(08:27) Why “make money” and “save money” alone are not enough to differentiate.(10:02) How to focus value messaging on the champion rather than every stakeholder.(13:31) Why teams should align on value concepts before worrying about copywriting.(17:23) How to separate true value from objection handling in your positioning.—Connect with April Dunford and learn about practical positioning that accelerates marketing and sales: Work with April: https://www.aprildunford.com/contact April's newsletter: https://aprildunford.substack.com/ April's LinkedIn: https://www.linkedin.com/in/aprildunford/ April's Instagram: ⁠https://www.instagram.com/aprildunford/ April's Twitter/X: https://twitter.com/aprildunford April's TikTok: https://www.tiktok.com/@positioningshow—Mentioned in this episode: * Obviously Awesome, Second Edition (forthcoming), by April Dunford. —Get April Dunford's books and audiobooks: “Obviously Awesome: How to Nail Product Positioning so Customers Get It, Buy It, Love It.”“Sales Pitch: How to Craft a Story to Stand Out and Win.”Amazon US: https://amzn.to/49l0ZRY Amazon Canada: https://amzn.to/4ac9hgt Amazon UK: https://amzn.to/3vosDzQApple Books: https://apple.co/3xihSzCGoogle Play: https://play.google.com/store/search?q=%22April%20Dunford%22&c=books Barnes & Noble: https://www.bn.com/s/%22April%20Dunford%22 Bookshop: https://bookshop.org/contributors/april-dunford —The Positioning with April Dunford podcast: Want to make your product stand out in a crowded market? It all starts with great positioning. Using April's battle-tested methodology, she'll teach you the nitty-gritty of positioning so that you can unlock better marketing and sales performance.Podcast website: https://www.positioning.show/ Subscribe on Apple Podcasts: https://apple.co/3PFHcWx Subscribe on Spotify: https://open.spotify.com/show/02XBrnPJ7NVGPUgHC7xstU Subscribe on YouTube: https://www.youtube.com/@positioningshow —This episode was produced by Story On Media: https://www.storyon.co/

“Being privately held and being a pure play spine company has given us the focus, the resourcing and the investment we need to, to really take this thing and make it hum,” Highridge’s CEO Rebecca Whitney says about the 7th largest spine company. In this Vanguards of Health Care episode, Whitney sits down with BI analyst Matt Henriksson for an in-depth interview about the path to a private company from a subsidiary under a major, publicly traded ortho company. As an independent company, she explains how it can be nimble in M&A, including the acquisition of key expandable spinal implants from Accelus and the recent PathKeeper agreement, both of which augment Highridge’s portfolio that houses its Mobi-C cervical disc replacement system and Tether motion preservation system. She also explains the importance of saying yes to new roles to build your career trajectory.See omnystudio.com/listener for privacy information.

What is instructional coaching—really? And how can coaches meet teachers where they are without forcing everyone into the same coaching mold? In this episode of the Time For Teachership podcast, Lindsay is joined by Chrissy Beltran, instructional coaching expert, host of Instructional Coaching with Miss B, and author of an upcoming ASCD book on differentiated coaching. Together, they unpack what it means to differentiate instructional coaching, define the coaching role clearly, and build authentic relationships with teachers—especially those who may be resistant to coaching. Chrissy shares practical strategies, mindset shifts, and real-life coaching stories that help instructional coaches move from uncertainty to clarity and impact. What You'll Learn in This Episode Why instructional coaching often feels "nebulous" and how to bring clarity to the role How to define your coaching vision  What it means to differentiate coaching instead of using a one-size-fits-all approach Low, medium, and high-impact coaching strategies—and when to use each How to work with resistant teachers without damaging relationships Why peer observation can be a powerful gateway into coaching How coaching can reconnect teachers to joy, play, and purpose  Timestamps [00:00] Welcome & introduction to Chrissy Beltran [01:00] Why instructional coaching feels undefined and isolating [02:30] Freedom dreaming: Chrissy's vision for education and equity [05:30] Coaching as play, exploration, and joy [08:00] Key mindset shifts when moving from teacher to coach [13:00] Defining your coaching role and vision [16:40] Differentiated coaching & the coaching toolbox [18:45] Low, medium, and high-impact coaching strategies [21:30] Working with resistant teachers: a real coaching story [25:00] Why visiting colleagues is a high-impact coaching move [30:00] Lightning round: next steps, learning, and resources  Key Takeaways Coaching is not about "fixing" teachers—it's about partnering to grow Every interaction with a teacher is a potential coaching moment Differentiation matters just as much for adults as it does for students Relationship-building strategies are not "low value"—they're foundational Peer observation helps shift beliefs without putting the coach at the center    Get Your Episode Freebie & More Resources On My Website: https://www.lindsaybethlyons.com/blog/243    Connect With Guest Chrissy Beltran:  Podcast: https://pod.link/1496989397 Website: https://www.buzzingwithmsb.com  Instagram: https://www.instagram.com/buzzingwithmsb/   

“We help companies drive growth. We deliver innovative solutions. We're customer-focused.” Sound familiar? If it does, your positioning probably sounds like everyone else's, and in a world where ChatGPT can generate endless value props in seconds, that sameness is now a real threat. In this episode of Pipe Dream, host Jason Bradwell talks with Christian Klepp, co-founder of EINBLICK Consulting, about why vanilla positioning is collapsing under AI pressure and how to build differentiation that actually holds up. Christian argues that the brands that win won't be the ones publishing more AI content. They'll be the ones doing deeper customer research, crafting a clearer point of view, and using subject matter experts as a defensible moat. Jason opens with the core problem: AI made generic messaging catastrophically easy to ignore. Christian explains what's changed recently, buyers increasingly use AI-assisted search and comparison tools that see through fluff faster than ever. It's no longer enough to say “we have AI.” Buyers want specifics: what is AI doing, how does it create value, and why should they trust your approach? They also address the pressure many agencies feel as clients expect AI to make everything cheaper and faster. Christian's take is that AI has no “soul”, no nuance, humor, lived experience, or real context. The winning strategy isn't volume (100 AI-generated blogs), t's choosing fewer topics and creating truly insightful, differentiated content that reflects real expertise. Christian explains why companies end up with bland positioning: fear of alienating prospects, cultures that reward safe messaging, and internal misalignment about what truly differentiates them. He's seen teams stuck in endless debates, leading to either analysis paralysis or messaging based purely on internal assumptions. His solution starts with a research strategy. He compares it to building a house - you wouldn't build without a blueprint. Likewise, you shouldn't build positioning without deep customer interviews that uncover why buyers chose you, what triggered the decision, and what language they use to describe value. That customer voice becomes the foundation not boardroom opinions. And if you think you don't have differentiation? Christian argues it's there, but often hidden. The answer lives with your customers and SMEs, you need to dig through interviews, sales calls, and objections to find the real demand triggers. Companies producing generic content will drown in sameness. Use AI intentionally, not as a replacement. Tap SMEs, listen to sales conversations, and build messaging from real expertise. If your positioning could've been written by anyone or any AI, this episode is the wake-up call you need. 00:00 - Introduction: The uncomfortable truth about your positioning 02:00 - Meet Christian Klepp and EINBLICK Consulting 04:00 - What's changed since AI went mainstream 07:00 - The agency tension: AI expectations vs actual value 11:00 - Why AI content lacks soul (and why that matters) 14:00 - Why companies default to vanilla positioning 18:00 - Using market research to break internal misalignment 22:00 - What to do when differentiation isn't obvious 26:00 - Differentiated perspective vs being opinionated 30:00 - The cybersecurity firm that got it right 34:00 - Is the media the new competitive moat? 38:00 - What happens to companies that don't adapt 42:00 - Final advice: Interview SMEs and sit in on sales calls Connect with Jason Bradwell on LinkedIn Connect with Christian Klepp on LinkedIn Visit EINBLICK Consulting Check out B2B Marketers on a Mission Podcast Explore B2B Better website and the Pipe Dream podcast

Episode 243Jamey Peavler discusses the importance of recognizing the varied learning needs of students in all grades! She emphasizes the distinction between comprehension and word recognition skills, advocating for differentiated instruction to better support each student's unique learning journey.Key TakeawaysWord recognition and comprehension can develop at different rates.Differentiated instruction is essential for meeting diverse learning needs.Teachers should empower themselves to adapt their teaching methods.Effective teaching requires awareness of students' varying skill levels.Teachers play a crucial role in bridging the gap between comprehension and skill. We answer your questions about teaching reading in The Literacy 50-A Q&A Handbook for Teachers: Real-World Answers to Questions About Reading That Keep You Up at Night.Grab free resources and episode alerts! Sign up for our email list at literacypodcast.com.Join our community on Facebook, and follow us on Instagram, Facebook, & Twitter.

A new year brings new market dynamics and fresh insight for municipal investors looking to stay ahead in 2026.In this episode, host Eric Kazatsky is joined by Mike Denlinger, Managing Director and Portfolio Manager at MacKay Municipal Managers, to walk through the team's Top Five Insights for 2026. From the resilience of essential service revenue bonds to the dispersion emerging in high yield, Mike shares what themes and strategies matter most in the current environment.They break down curve positioning, taxable muni opportunities, and how active flexibility can uncover value where passive strategies fall short. If you're positioning muni portfolios for the year ahead, this conversation is packed with data-backed takeaways.Follow UsTwitter @NYLInvestmentsTwitter @MacKayMuniMgrsFacebook @NYLInvestmentsLinkedIn: New York Life InvestmentsLinkedIn: MacKay Municipal ManagersPresented by New York Life Investmentswww.newyorklifeinvestments.comMacKay Municipal Managers is a team of portfolio managers at MacKay Shields. MacKay Shields is 100% owned by NYLIM Holdings, which is wholly owned by New York Life Insurance Company. “New York Life Investments” is both a service mark, and the common trade name, of certain investment advisors affiliated with New York Life Insurance Company.SMRU: 8563817 Hosted by Simplecast, an AdsWizz company. See pcm.adswizz.com for information about our collection and use of personal data for advertising.

In 2026, investors continue to face volatility and uncertainty. How can they seek to access differentiated alpha through targeting potential market dislocation?In this podcast, Adil Mirza, Senior Fund Manager within our Global High Yield team, shares his views and process.For professional investors only. Capital at risk.

What does it take to build products that stand out in one of the most technical spaces in the industry? In this podcast hosted by Cassio Sampaio, Nutanix Vice President & General Manager Dan Ciruli speaks on how product leaders can guide customers through complex infrastructure decisions and stand out in ecosystems dominated by hyperscalers. He explores the realities of legacy systems, the skills PMs need to thrive in deeply technical environments, and the opportunities emerging across the evolving infrastructure stack.

Send us a textIn this episode of WTR Small-Cap Spotlight, host Tim Gerdeman and analyst Robert Sassoon speak with Shaun Bagai, CEO of RenovoRx (NASDAQ: RNXT). The company is pioneering targeted oncology therapies and commercializing RenovoCath™, an FDA-cleared multi-specialty local drug delivery device for high unmet needs. We discuss the innovation and advantages of its TAMP™ (Trans-Arterial Micro-Perfusion) platform—powered by the proprietary dual-balloon catheter—and how it sets RenovoRx apart in treating hard-to-reach hypovascular tumors like pancreatic cancer. The conversation also covers RenovoCath's commercialization strategy and key milestones in its Phase 3 clinical trial aimed at proving the platform's delivery superiority over the current standard of care.

In this week's episode of the B2B Marketing Podcast, David Rowlands spoke with Paul Collier, CMO, FunnelFuel; Chris Omotosho, Managing Director, UK, Gravity Global; Nick Watmough, Executive Creative Director, The Croc; and Jon Buckthorp, Commercial Director, Differentiated. As we close out 2025, it only felt right to end with a conversation inspired by the year's standout work. Drawing on insights from across agency, brand and creative leadership, the panel discusses what made this year's award-winning campaigns at the B2B Marketing Awards resonate. The conversation opens with a focus on the growing role of emotion and creativity in B2B, with brands increasingly doing their best work by connecting on a human level. From there, the discussion turns to the rapid influence of AI, the rise of experiential marketing, and a noticeable shift away from product-first messaging in favor of more meaningful, human-to-human engagement in an increasingly AI-driven landscape. The panel also reflects on Gravity Global's ‘Global B2B Agency of the Year' win for the second year running, before diving deeper into some of the more thought-provoking themes emerging from the awards. In particular, Jon explores how concepts like content dysmorphia and thought theatre are influencing both creative strategy and how brands show up in-market (ideas first unpacked in a previous episode with Differentiated). If you're curious about the other award-winning campaigns highlighted at our 2025 awards, check out our Winners Report here: https://www.b2bmarketing.net/reports/b2b-marketing-awards-winners-report-2025/

Every December, we wrap up Content Marketing, Engineered with a tradition: a trends conversation with TREW Marketing's own Lee Chapman. This episode focuses on how Industrial Marketers can reckon with with the new age of AI and differentiate themselves among a "sea of sameness" and what marketing strategies to focus on in 2026. 2025 was a year of massive transformation for industrial marketers. As AI tools matured and generative search became a primary gateway for technical buyers, long-standing content and inbound strategies were forced to evolve. Marketers saw firsthand how important differentiation, depth, and authentic expertise is to stand out and earn trust.AI Has Leveled the Tactical Playing FieldAccording to Lee, 2024 and 2025 were years of experimentation. Marketers used AI to produce content faster than ever but this caused everyone to sound alike and create an overwhelming amount of noise. Lee says the biggest trend for 2026 is a differentiated strategy.With AI providing instant answers to basic queries, surface-level content no longer cuts it. Technical buyers still end up on your website, and when they do, they're looking for clarity, technical depth, and authenticity. If your content doesn't communicate a strong value proposition and true expertise, it's easy for prospects to bounce back to AI or head to a competitor.Your Website Must Earn Its KeepLee highlighted two extremes plaguing engineering websites today:The “museum” site: outdated, bloated, and difficult to navigate.The “brochure” site: modern and pretty, but shallow, lacking specs, case studies, and proof points.Both fail to meet the needs of technical buyers. Lee recommends a website and content audit using a keep/kill/create framework, elevating high-value content, and ensuring users can find what they need with minimal clicks.Trade Shows: Substance Over SwagEvents are booming again, but many companies are “checkboxing” their presence rather than building a strategic plan around them. Lee stressed the importance of:Strong booth messagingDemos and SMEsPre-event outreach and partner activationThoughtful, timely post-show follow-upContent: Go Deep, Get Specific, Prove ItTechnical audiences still value white papers, webinars, case studies, and research if they contain meaningful depth. Lee emphasized developing more proof-driven assets, including unnamed case studies when needed, and turning high-performing content into webinars or videos. Voice-of-customer research and even closed-lost surveys are underrated tools for uncovering differentiators AI can't replicate.ResourcesConnect with Lee on LinkedInConnect with Wendy on LinkedInLearn more TREW's Marketing Strategy servicesRegister for the Industrial Marketing Summit

With updated thyroid cancer guidelines, adjunct diagnostic and treatment tools, and growing interest in minimalist approaches, it is increasingly challenging to know the optimal management for patients with small, differentiated thyroid cancer including when to refrain from operating. In this episode, we discuss the nuanced decision making in managing these patients, the multiple factors that are taken into consideration, and strategies in conducting efficacious conversations with patients. Hear from our world-renowned expert panel, Dr. Michael Tuttle, Professor and Chief of Endocrinology at Memorial Sloan Kettering Cancer Center, and Dr. Douglas Fraker, The Jonathan Rhoads Professor of Surgery Emeritus at the University of Pennsylvania , moderated by Dr. Mahsa Javid, Endowed Chair in Endocrine Surgery.

Dr. Carrie Rose reveals how to use AI and ChatGPT to create online courses that students actually finish. Learn artificial intelligence strategies for course creators, educators, and entrepreneurs building profitable online education businesses.In this episode, NaRon and Dr. Carrie Rose break down the intersection of AI tools and online course creation—covering everything from avoiding common AI mistakes to improving course completion rates. Whether you're new to AI for beginners or scaling your online coaching business, you'll discover practical methodologies for leveraging generative AI without losing the human touch.WHAT YOU'LL LEARN:✅ How to use AI as a tool (not a crutch) in course design✅ Strategies to increase student engagement and completion rates✅ Building effective online course funnels in 2024✅ Differentiated learning approaches for online education✅ Real talk about AI limitations and hallucinations✅ Dr. Rose's personal journey overcoming challenges in entrepreneurshipTIMESTAMPS:00:00 Using AI for Relationship Advice00:17 Finalizing My Book and Course Alignment01:41 The Changing Landscape of Online Funnels02:30 Introduction to Walking Victory Podcast03:03 Impact of AI on Content Creation03:58 Missteps in Using AI for Methodology05:02 AI's Limitations and Hallucinations08:06 Personal Journey: Overcoming Challenges09:59 Building a Business Model in Online Coaching19:27 Effective Online Course Creation33:26 Conclusion and Call to ActionCONNECT WITH DR. CARRIE ROSE:Become a supporter of this podcast: https://www.spreaker.com/podcast/walk-in-victory--4078479/support.

Dots Oyebolu speaks with Isaac Rudansky, CEO of AdVenture Media Group. Isaac shares practical ways to build commercially profitable omnichannel ad strategies and why CRO is the fastest path to improving profitability. He explains aligning production value with audience expectations, clarifying messaging and structuring tests that move the needle. He also covers the mindset required to launch and scale, emphasizing persistence, value and channel fit.Key Takeaways:00:00 Introduction.02:36 Improving conversion rate lowers acquisition cost and lifts profitability.05:43 Design should reflect the brand and audience to protect performance.08:51 Clear copy communicates value and advances the decision-making process.11:13 Quick clarity tests validate positioning and reveal missing information.13:00 Differentiated factual copy strengthens credibility and avoids generic claims.20:48 Persistence and consistency are essential during early launch setbacks.24:13 Value offered at a fair price underpins sustainable results.26:09 Competitive markets are not level, so strategy and data matter.Resources Mentioned:Isaac Rudanskyhttps://www.linkedin.com/in/isaacrudansky/AdVenture Media Group | LinkedInhttps://www.linkedin.com/company/adventure-media-group-llc/AdVenture Media | Websitehttp://adventureppc.comInsightful Links:https://www.singlegrain.com/blog/ms/omnichannel-marketing-strategy/https://www.mckinsey.com/featured-insights/mckinsey-explainers/what-is-omnichannel-marketinghttps://advertising.amazon.com/en-ca/library/guides/omnichannel-marketingThanks for listening to the “Marketing Leadership” podcast, brought to you by Listen Network. If you enjoyed this episode, leave a review to help get the word out about the show. And be sure to subscribe so you never miss another insightful conversation. We appreciate the enthusiasm and support from our community. Currently, we are not accepting new guest interview requests as we focus on our existing lineup. We will announce when we reopen for new submissions. In the meantime, feel free to explore our past episodes and stay tuned for updates on future opportunities.#PodcastMarketing #PerformanceMarketing #BrandMarketing #MarketingStrategy #MarketingIntelligence #GTM #B2BMarketing #D2CMarketing #PodcastAds

In this episode, Bridgette and Irvine explore what it means to be a well differentiated leader and the difference that it makes for people, teams and organizations. They define what this form of leadership looks like, the essential building blocks that are needed to embody it and share practical examples from everyday day work and life

In this week's episode of the B2B Marketing Podcast in association with Differentiated, we are joined by Jon Buckthorp, Commercial Director, Differentiated to discuss the agency's latest report: Art & Science: Exploring new horizons built on belief. The conversation begins with a thought-provoking look at the difference between trust and belief, before Jon shares some striking findings from their in-depth research. For example, did you know that decision-makers are spending around two hours a day engaging with marketing material, yet many don't finish what they start, and two thirds never make it to the conclusion? This was just one of many takeaways discussed in the episode. From there, Jon defines content dysmorphia and thought theatre, and explains how these play out in today's marketing landscape. Jon also considers the role of AI in an increasingly sceptical climate, raising important questions about how brands can cut through and connect meaningfully. If you're curious about any of these themes from the report then this episode is a must-listen.

With over 30 years in wireless—from helping pioneer intercarrier SMS to running mobile identity operations across Americas and Asia Pacific — Eddie DeCurtis saw what others missed: 967 of 1,000 global mobile network operators lack the infrastructure to monetize CPNI data while protecting customers from fraud. The technical challenge isn't building APIs. It's that operators spent billions on 5G infrastructure and now lack capital, internal expertise, and operational frameworks to launch authentication services. In 18 months, Shush went from PowerPoint to 30 employees, supporting 47 network APIs with full GSMA Open Gateway compliance. Eddie shares how understanding regulatory frameworks by jurisdiction, not just deploying technology, became their competitive moat—and why hiring the executive who built T-Mobile USA's authentication platform gave them credibility no competitor could match. Topics Discussed: Why operators repeatedly said "we want to do it, we have no idea how, we have no money, we don't have a platform" Validating the thesis with former AT&T Communications CEO John Donovan before launching Securing a POC with a major operator pre-incorporation—with only a PowerPoint deck The three-legged stool: technology, network integration, and business operations (where competitors fail) Why knowing privacy regulations for CPNI data sharing by country became a deal-closer Reducing network integration from dozens of touchpoints to three specific network elements Supporting 8 Linux Foundation Camara APIs and TS.43 GBA AKA authentication standard Going from 3 to 30 employees and launching at Mobile World Congress on a $75/night Airbnb budget GTM Lessons For B2B Founders: Validate with the person most likely to kill your idea: Eddie deliberately chose John Donovan—former CEO of AT&T Communications, board member at Lockheed and Palo Alto Networks—specifically because "he's going to be rough, he's going to totally ask the really hard questions." When Donovan's response was "go raise $40 million and own this space...you're not going to be alone for long," the validation carried weight because it came from someone incentivized to find fatal flaws. Most founders validate with friendly audiences or investors looking for deals. Find the battle-tested executive who has nothing to gain from being kind. Convert pre-product conviction into design partner commitments: Eddie secured a POC agreement with a major operator before Shush incorporated. "I had nothing. I didn't have software. We had an idea, we had a PowerPoint presentation." This only works when you've spent decades building domain expertise and relationships. The lesson isn't "sell vaporware"—it's that deep industry knowledge lets you articulate problem-solution fit so precisely that sophisticated buyers commit before seeing code. Infrastructure founders with 10+ years in-market can accelerate 12-18 months of product-market fit by converting expertise into early design partnerships. The enterprise moat is operational knowledge, not technical capability: Eddie's thesis: "Anybody can come up with the technology. You walk down the street in the Bay Area, 10 developers will develop it for you." Shush differentiated by answering questions competitors couldn't: How do you price SIM swap detection per query? What are CPNI data sharing regulations in Indonesia versus Brazil? How do you navigate internal stakeholder alignment across legal, privacy, and regulatory teams at a tier-one operator? When Eddie told an operator "here's the privacy rules for your country" after they admitted "I have no idea," he closed a knowledge gap that pure technology vendors can't fill. In regulated infrastructure markets, execution expertise beats technical superiority. Target the ambition-capability gap in capital-constrained buyers: Operators told Eddie the same story: eager to launch authentication services, zero clarity on execution, budgets decimated by 5G spending. This created perfect conditions for a full-stack solution. "Mid-market is hard because you have a buyer with problems that are not basic anymore, but they lack the ability to execute." Shush didn't sell point solutions—they delivered technology, integration, and business operations as a turnkey package. Identify buyers with sophisticated needs, strong intent, and constrained internal resources. That's where full-stack platforms win over point tools. Hire the operator who ran your exact use case at scale: Eddie cold-called John Morrowton, who "built this actual product and service offering at T-Mobile USA, from its inception to its execution and ran it for four years." His pitch: "I'm Eddie DeCurtis, how are you? You want a job? You're Chief Product Officer." Hiring someone who'd operationalized authentication services at a tier-one carrier gave Shush instant credibility with operator buyers and compressed years of trial-and-error into institutional knowledge. In infrastructure sales, hiring executives from reference customers eliminates "can you actually do this" objections before they surface. Minimize integration surface area to accelerate deployment: Mobile operators run highly secure networks with limited external access points. Shush "narrowed it down to three network elements that we can communicate with to provide all 47 APIs." Fewer integration points means faster deployment, lower implementation risk, and reduced operator IT overhead. This architectural decision became a sales accelerator. Infrastructure founders: identify the minimal viable integration that unlocks maximum API coverage, then make that your differentiated deployment story.   //   Sponsors: Front Lines — We help B2B tech companies launch, manage, and grow podcasts that drive demand, awareness, and thought leadership. www.FrontLines.io The Global Talent Co. — We help tech startups find, vet, hire, pay, and retain amazing marketing talent that costs 50-70% less than the US & Europe. www.GlobalTalent.co // Don't Miss: New Podcast Series — How I Hire Senior GTM leaders share the tactical hiring frameworks they use to build winning revenue teams. Hosted by Andy Mowat, who scaled 4 unicorns from $10M to $100M+ ARR and launched Whispered to help executives find their next role.  Subscribe here: https://open.spotify.com/show/53yCHlPfLSMFimtv0riPyM

Lee Salz is the founder and CEO of Sales Architects®, a globally recognized sales management strategist, bestselling author, and keynote speaker. Widely respected for challenging outdated sales methods, Lee equips organizations with powerful sales strategies, playbooks, and processes that drive explosive, profitable growth.His insights have helped hundreds of companies differentiate themselves and develop world-class salesforces. As the author of several bestsellers—including Sales Differentiation and his latest, The First Meeting Differentiator—Lee is on a mission to transform how companies approach sales conversations, starting with the very first meeting.SHOW SUMMARYIn this episode of Selling from the Heart, Larry Levine and Darrell Amy welcome back Lee Salz for an insightful conversation about the critical role of the first meeting in the sales journey.They explore what it means to sell from the heart—leading with authenticity, human connection, and emotional awareness. Lee explains why most sales professionals fail to differentiate themselves early on and how to fix it.From practical strategies to ask emotive questions, to why you should always end meetings with clear next steps, this episode is a goldmine of advice for sales professionals who want to build deeper trust, deliver meaningful value, and win more deals. KEY TAKEAWAYSAuthenticity wins — make people feel seen, heard, and valued.Meaningful value comes from understanding the client's emotional and strategic needs.Emotions drive decisions, but most sellers only use logic—learn how to tap into both.Differentiate in the first meeting by asking better questions and leading with empathy.Clarity matters — end every meeting with clear next steps and a follow-up.Language is powerful — say “investing time,” not “spending time.”HIGHLIGHT QUOTESPerson before prospect. Until you understand them as a person, you can't possibly have them as a prospect.Don't forget to say: ‘Thank you for investing time with me today.' Not spending time, nvesting it.People buy based on emotion and justify their decisions with logic—but nobody's doing it.The problem with your case is it's all facts, no heart—and the jury isn't buying it.

Drs Kaniksha Desai and Julie Ann Sosa discuss the 2025 American Thyroid Association guidelines for the management of differentiated thyroid cancer. This podcast is intended for healthcare professionals only. Kaniksha Desai, MD, Associate Professor of Medicine, Department of Endocrinology, Stanford School of Medicine, Palo Alto, California Julie Ann Sosa, MD, Professor, Department of Medicine, University of California, San Francisco (UCSF) To read a partial transcript or to comment, visit: https://www.medscape.com/index/list_15483_0

According to research from Gartner, buyer uncertainty leads to a 30% reduction in a buyer's ability to make a purchase decision at all. So, how can you create a buying experience that builds confidence, drives engagement, and ultimately improves win rates? Riley Rogers: Hi, and welcome to the Win-Win podcast. I’m your host, Riley Rogers. Join us as we dive into changing trends in the workplace and how to navigate them successfully. Here to discuss this topic is Annabel Hosking, Global Sales Enablement Manager at LexiNexis Risk Solutions. Thank you so much for joining us, Annabel. Just to kick us off, I’d love if you could tell us a little bit about yourself, your background, and your role. Annabel Hosking: Hi everyone. I currently work as a global sales network manager at LexisNexis Risk Solutions within the data services brand, so I’m very fortunate to work across. Four different brands that will work within the data space. And within my role, I lead the sales enablement team. We’re a global team. We’re a small team, small but mighty, and we work across methodology enablement. So all about our sales methodology, how we go to market, how our customers. Experiences. And I also work across all of our onboarding as well as all of our tech stack as well. So my role is really varied. I’m very lucky I get to work with some really great people across the world. And yeah, it was never a dull moment, I’ll say. RR: Isn’t that always the case? Small scrappy teams. Wearing a lot of hats and it’s always exciting. We’re super excited to have you here because I know you have experience spanning a lot of core parts of enablement, so I think there’s a lot to dig into there. Could you walk us through, because I think everybody’s story is different, maybe your professional journey and then how that background led you to enablement, and then how it’s kind of shaped your approach to enablement today. AH: Absolutely. I have what I like to think of as, and it comes from a podcast I’ve been listening to recently, it’s called Squiggly Careers, and I feel like my career was like a very squiggly career of how I ended up in enablement, because I did not at school think, oh, I’m gonna become a. Sales enabler whatsoever. But my background is very much actually in content management and platform management and communication. And how I moved into enablement was I was actually hired in my current company and one of the brands, the beginning of the pandemic. To essentially deliver enablement content. So I worked on delivery of content, content management, delivery of our Highspot system as well. And that was how I started to move into the enablement realm. And I will say it was completely unknown to me originally. I. Wasn’t even clear that I was doing sales enablement per se, but at least a good 18 months in my role here. I thought I was just delivering content and it wasn’t until working with vendors like Highspot where. That term enablement started to come out and it started to change, I suppose, how I delivered my content and it’s really come into its own where now I’m very fortunate where I’m have on my team who does phenomenal content and through my experience. It’s really understanding who my audience is, understanding how they like to consume their enablement, but also how can we consistently stay, um, ahead of what the trends are and how people like to change, how they like to consume, what they’re seeing A meeting was held by our team on Monday with the client team for the Zephyr project to review the status of the forthcoming Q3 launch campaign. The campaign, originally built as a omnichannel activation across CTV, paid social and programmatic display, is now subject to substantial midstream revisions—following newly surfaced client directives. The feedback introduce a material shift in strategic framing under a compressed delivery window. There will be a pivot as Zephyr deprioritizing the performance-tracking narrative to favor of a broader “everyday wellness and inclusivity” story which will require an immidiate reframe of our messaging, architecture and associated visuals. To addressed the revised scope, I've assigned immediate follow-ups actions across the team. Visual art will lead conversations with post-production around stock content intergration. Ad sales will recalibrating the media plan in light of the repositioned messaging and will coordinate with DSPs to avoid penalties related on insertion order delays. Copy desk is to be tasked with stripping all unsubstantiated medical claims from copy, implementing the new CTA and managing a parallel review with legal. We conduct a daily internal stand-up each morning through end of week to identify blockers. The next client check-in is scheduled for July 3rd, where we preview asset revisions and confirm compliance milestones. Final go/no-go is slated for July 7th at 17:00 PDT. We are proceeding with all mitigations in parallel, and escalated any dependency delays as they surface. day to day, because that has vastly changed as well in the last six years. So. Thankfully my background and being adaptable, working globally, working with a lot of different people has really helped shape that. Because you know, I always say if there’s one thing, so my career of, you know, working in content management and working with platforms, working in technology. It has really shaped who I am today because it’s all really embedded in those user Jo Journeys user stories, and that translates into what I hope is a good enablement experience. RR: Well, amazing. I love the phrase squiggly career. I think I am certainly going to have to steal that one, and I think it’s such a good way to describe how so many folks end up at enablement. You start in one place and you bring all of that knowledge that you acquire in that early discipline. Into enablement programming that’s more effective for it. And thinking about, you know, your background in content management and creating content and all of that fun stuff, I’d be curious to know how they kind of come together. So you recently spoke at Spark EA and highlighted the importance of the buying experience, so. What are you seeing as some of those biggest challenges in engaging today’s buyers and how are you addressing them? Maybe through content, maybe through enablement? What does that look like to you? AH: I mean, I think the buying experience today in 2025 is unlike anything we have seen. Ever. It is a completely different world for both salespeople and for buyers as well. And what I’m seeing is, you know, buyers are not only overwhelmed with information, they’re also inundated with it. There is so much content out there for a buyer to consume and not just through their sales individual. This is content that they can easily go and either get themselves or with things like AI and Copilot, they can have. Harness and surface to them. So that makes the role of the seller that much harder because we don’t always know what the buyer is viewing and whether it’s of value to them, and that means that their time, the buyer’s time is so precious. We are seeing that, you know, buyers, and I mentioned this when I was at Spark, there are so many people now involved in the buying decision. We’ve moved, I think it was from about three people a few years ago. We’re now at. Six to 10 people. And if you think about it, those are all new personas that sellers have to understand, have to get to know, potentially map out, connect with. And what’s really unfortunate is we’re also seeing that for a lot of sellers, our buyers are actually taking. Long to make a decision that they kind of get to a point of no decision. We’re at this decision fatigue. We’re a information fatigue, we’re a decision fatigue. And I think on the whole, our buyers are they tired. And I can talk as a buyer, myself as a customer, it’s really exhausting. And so what we try to encourage where I am in data services is sales have to differentiate themselves. If you wanna get in front of buyers nowadays, you have to think what are you bringing to the table that’s different from them? That’s a unique experience, that’s an experience that makes ’em feel important, makes ’em feel, listened to, makes them feel like they really can understand why we are doing business together. And that starts in how we as enablement get that content to our salespeople. If we are not able to identify the value that we are bringing as brands into that conversation, it becomes really hard for sales to know how to articulate that to the buyers as well. And so. As enablement, we are that bridge between the, a lot of other functions and the sales teams and the commercial teams of making sure that value identification is really clear. So by the time it reaches the buyer, they absolutely know why they’re having that conversation. They absolutely know what the value of that conversation is going to be. And that really does start with how are you getting that information into the hands of your salespeople? How are you making that content? Really accessible, really palatable as well. I think traditional enablement, we defer to a lot of very wordy, very long documents, which from experience, no salesperson really wants to read or look at or go through. So just as we’re seeing the buyers experience evolve, the enablement experience has to evolve as well in order to stay ahead of that and to give them the best experience to our salespeople. RR: I think you’re absolutely right on all of that. It is only getting more difficult, and as things change externally, you need to adapt internally. And so kind of thinking about how you’re making that change, and to your point, how you’re distributing materials in a way that is usable and usable for a sales audience that maybe isn’t gonna read 10 pages of written content. What would you say then is kind of the unique value for an enablement platform when it comes to helping sellers? Create and deliver these impactful and differentiated buying experiences that you’re looking for? AH: Oh, huge value, absolutely huge value. The power of enablement comes in the ability to be able to streamline that messaging. But in order to do so, we do need a channel to do that, you know, and that can’t exist. In ad hoc documents that you just hold on someone’s computer. Our journey with Highspot started many, many years ago. I think it was about sort five or six years ago, very early days for Highspot even themselves. And we set out with a mission statement, which was that Highspot would be a single source of truth holding up UpToDate relevant sales content. And I am happy to say that five years later we still maintain that mission statement. The platform has got bigger. There’s more people, there’s more content, as I’m sure you can imagine, but we have stuck to our statement that it is a single source of truth. It is up to date, it is valid information that sales are getting, but that all comes from having a channel with a witch to push that through to the sales audience. It just makes your role as an enabler that much easier, you know, day to day. As you know, we spoke about at the top of the call is no one day looks the same for enablement. It will always be different. There’ll be different priorities. There’ll be different go to market, there’ll be different initiatives. But if you know that at least you have somewhere that you can reliably put information in front of sales and then see how it’s being used, how it’s being impacted, how the seller is using it, how the buyer’s consuming it. Your role as enablement starts to become just a little bit easier. And so I would say for anyone who’s within the enablement sphere and looking at their tech stack, having a solid CMS is really gonna be a, a strong cornerstone of that. RR: I love the perspective on an enablement platform as kind of a source of consistency. Almost everything is changing. Your day in enablement is different. Buyers are behaving differently. Reps need to do different things to engage ’em, but at least you have one place that is reliable. But I will say, I know that. Strong buying experiences aren’t necessarily contingent just on technology. They also require a lot of hard work internally. And as one of the things that you, I’ve seen you mention on LinkedIn is that a core foundation of LexisNexis Risk Solution Services is ensuring that customers really recognize the value that you provide. And that kind of starts internally. With sales and leadership alignment. So I’m curious, how are you aligning those internal stakeholders so that way your teams are set up for success when they’re shaping those buyer experiences externally AH: with immense difficulty, I’ll say, and I think any enabler that sits here and says that it’s an easy job is lying through their team. It is, I think, one of the hardest, the hardest roles. Of enablement is getting everybody aligned, getting everyone to agree, and especially I work, as I say, across a lot of businesses. You know, I have four MDs, I have four heads of sales, I have a lot of sales leadership and a lot of sellers, and I’m sure that’s the case for a lot of people working in large enterprise organizations, stakeholders. Can be difficult to align, especially when you have a lot of different priorities and a lot going on. But what I would say is, is really identify what is the core value that you as a company or you as a business, as a brand can all agree on. Our MD has this thing, he says that all of our kickoffs, which is, you know, value is not on the lips of the seller, but is in the eyes of the customer. And that mission statement as it were. Has sort of brought all the stakeholders together to agree that even if there’s misalignment or disagreement on how we do things, we can all agree that we want to give the best experience for our customer and the best value to our customer. And so for enablement, it’s then saying, okay, so we have this mission statement, we have this belief that we want to be customer centric. We want to be value focused. What does that actually mean? For each internal stakeholder, what’s important for them? What are the metrics that they’re looking at day to day, month to month, quarter to quarter, and how is what we are doing with an enablement? How is it actually starting to impact that? Where is their focus? What are they going after? And the only way you are really gonna get those answers is by talking to your stakeholders. If you’re an enablement and you’re not a people person, it’s probably gonna be quite a tough job because a lot of our job is just talking. It’s talking with people, talking, you know, at people, sometimes listening to people, taking in information. I would say spend time with your stakeholders. You are there to listen first and foremost. You can’t solve every single problem that they come up with, and you shouldn’t try to. But if you can really understand what their world looks like and what’s really important to them, and what are the behaviors, what are the metrics that are gonna move the dial for your stakeholders? You’ll eventually start to map out, which is what we did. But actually a lot of them start to align. And even though they might be saying different things, the reality is that for a lot of sales leadership, they want similar things. You know, they want to have better pipeline hygiene, they wanna have higher wind rate. They wanna see, you know, large opportunity amounts more in the qualifying, the identify stage, that early sales stages, they wanna increase, you know, the ramping of new starters. We start to get these similar uniform metrics and so then we as enablement can start to work that into our strategy. Although we as enablement can really start to build what we are working on to align with our internal stakeholders and start to deliver for them. RR: I really appreciate that you had some really tactical and helpful tips in there, but also that you led with, this is not easy. That’s the big part, is there’s so many kind of lofty initiatives that you are like, how do I even tackle this? And it sounds so overwhelming. So I appreciate the acknowledgement there. Kind of wanna shift gears a little bit maybe towards some of the capabilities that you’re using and finding some success with. So one of the things that we’ve heard is that digital rooms have been a lever for kind of creating those differentiated buying experiences. So what are some of your best practices for creating effective digital rooms and then maybe getting your teams to leverage them. AH: Mm, absolutely. We have a brand who is using digital rooms really fantastically, and they’re teaching our other brands how they’ve used them. So, you know, I, I wholeheartedly agree they can make such a difference in the buying experience and if you’re not using them, you should a hundred percent be looking into where you can use them. So I would say when you are looking to start with a digital room is really understand. Why are you doing this? Like what’s the purpose of actually taking the time and the effort to work probably with your product marketing team or with your marketing teams as a whole to put together something that looks really professional. Looks on brand, but is also really easy for sales to go in and start to customize. I would recommend not having sales do it fully themselves. They have very busy day jobs, and I think if you’re gonna say to any sales person, okay, over to you to go and create this, you might run. Some adoption issues, however, working, you know, this is where your cross-functional working really becomes essential, is working with the individuals who can make good content, who can deliver good, uh, visuals, good framework for the salespeople to literally just be able to, within their sales cycle, adopt this, lift it, and send it to the customer. Because then we start to see, okay, where are we actually starting seeing the customer impact? Has it changed how the customer engages with the content? Are they revisiting? And so what we’ve seen is we’re actually looking at, you know, we see a much higher engagement rate when we have the customers viewing content through a digital room as opposed to simply. Static content, and we can see that obviously with the Highspot metrics, which you know, are a real gold dust when it comes to that. We can also see that, you know, we have repeat visits, so something that we wanted to drive was customers coming back and revisiting the content rather than just clicking in, seeing it once and then never viewing it again, was actually having that revisit of them continually coming back to their individual microsite, if you will. You know, we spoken a lot about a differentiated. Differentiated buying experience. And that can be challenging for salespeople because unless you are fortunate enough to only have you know four or five accounts, the likelihood is your book of business is probably quite vast. And so the expectation that you are consistently offering a differentiated variance for every single customer is just not sustainable. And so using these digital rooms, you are able to. Have, you know, a differentiated experience that is scalable. That it makes a buyer feel like it’s a really individualized experience when the reality is for sales, it’s probably quite an easy thing for them to put together, but it does take some uplift front end with your other teams and your cross departmental functions. RR: Yeah. I wanna double click it as something you said there, which was, if you’re asking reps to build it themselves, you’re probably not gonna see much in the way of adoption. I, I kind of wanna. Speak about that idea of what you can do to drive adoption more broadly. Because looking at the data, you’ve achieved a really impressive 82% recurring usage rate in Highspot. So in addition to that kind of approach to digital rooms, how are you driving adoption more broadly across your revenue teams, whether that’s internal reps, partners, whomever, what are you thinking about that’s helping you? Get people in the platform and keep them there. AH: Yeah. That’s been, you know, a metric we’re very proud of. And it’s been something where, you know, going back to what I said earlier, which is Highspot was set out to be the single source of truth. As soon as we turned on Highspot, for lack of a better word, we pretty much turned off every single other site. So there was nowhere else. For sales to go to get this information apart from this one platform. And I’ve seen this done various ways. I’ve seen people where they have, you know, duplicates and, oh, we’re doing a slow migration. We’re gonna keep SharePoint for a while, and then we’ll have Highspot as well. And you know, there’s no right answer to this, but ultimately, if you are looking to put out a message that this is your single source of truth, this is where you need to go to speak to sales. Our adoption has come because we really drove that and we continue to drive that. If you want content in front of sales, if you want success stories in front of sales, whatever it might be, it has to live in Highspot because there just simply isn’t anywhere else to go. And this is for a couple of reasons. The main one being that, you know, the actual management of the content is far easier. And if you think about the trickle down effect, the user needs the best experience possible. And so if they have all of this disjointed experience of going to multiple places to find multiple pieces of content that look different, that sound different, they’re not getting the best experience and they’re probably not gonna come back to Highspot. So for us, it’s really making sure I’m maintaining. The consistency in the user experience, and that comes from feedback as well. So we will regularly have feedback forums with our salespeople, with our sales leadership, and we’re very open within our team to hearing, listen, this is actually getting quite complicated to navigate. I dunno how to find content. And so then we as a team, as an enablement team, go, okay, what do we need to do to make it easier? How do we start to surface more content directly in front of our users? Because if they’re not having a good experience, then we are not doing our role as enablement. And you know, you don’t have to, if you do have a large sales team, you don’t have to have that verbatim feedback. You can use things like the search reports in Highspot to see, you know, what are people searching, what are the terms they’re looking for and the pieces of content, how can you start to surface that in front of them in a much easier way? Putting it on the homepage, putting it into their specific areas, really thinking about how you. Manage, maintain and govern that content to give your users a really solid experience. And that’s what we’ve done and it’s reflected, as I say, in the adoption and in the revisit rates as well. RR: I really like that you called out that search results report because I think that’s such a great way to kind of get a pulse on your people without having to go dig around and have a bunch of conversations. So thinking in addition to that, how do you leverage data and insights in the platform to help you inform and improve the programs you’re leading? AH: Yeah, absolutely. I mean, I have actually had to learn to, I suppose, step away from data slightly. Um, so that’s been feedback I’ve had as I’ve moved more into a, I suppose a leadership role is actually the data can’t always tell the whole story, although my heart and enablement goes, yes, it can, it can. But yeah, the. The, the scorecards that we have in high spots. So really for us, you know, looking at things like that play scorecard, we deliver a lot of sales plays. They’re the best way to get our enablement in front of people. They’re enjoyed and they’re liked by sales. But I can see very clearly what is the percentage of my audience that is viewing this play? How long are they spending? You know, what are the outcomes of the, you know, the business impact? At what point in the sales cycle as well? If there’s external content in there, for example, the marketing collateral, are they deploying this collateral and is it actually having any impact on the customer? Those sorts of insights. You just do not get anywhere else within any other content platform that we have. And so when it’s come to say, onboarding our marketing team or our product team into contributing content, being able to give them this insight helps them understand that the work they’re doing on building the content, maintaining the content is actually worth something because we can directly see the correlation with business outcome, which has always been one of our biggest challenges. Beyond that, our company does a lot with actually pulling the data out of Highspot. So we make use of the Highspot data lake, and we’ve actually pulled that into our own BI platform where we’ve started to look at things around, you know, how many channels and how much activity per opportunity are we seeing within sales. Something at the moment that we’d really drive on. Going back to that differentiated experience for the buyer is looking at a multi-channel approach when it comes to how we prospect and how we outreach. And that really started from using information that came from Highspot, looking at information that comes from Salesforce and going, okay, how many channels do people currently use when they’re outreaching? We’re only maybe seeing a couple, you know, one or two channels. But we know in today’s buying world that it’s gonna take between six to eight. Channels to get through to a buyer and to actually have a meeting. So what can we do to start to move the dial and start to build our programs across driving that? And so that’s how we use data and enablement is actually saying, what are we seeing today? What are the outcomes we want to see in the next quarter? What do we need to do in order to get there? There’s always a lot of talk on LinkedIn. I always see it about, you know, you need to be data driven and enablement. If you’re not offering insight, if you’re not offering analytics, you’re not doing your job. And that can be kind of hard to hear when actually, I think there’s almost too much data sometimes, and it can be quite complicated to understand. And this is why I, I personally really like how it is viewed in Highspot because the scorecards make it very accessible, very easy to consume, but also it doesn’t matter whether you’re an enabler, a seller, or a senior leader, you can be presented a scorecard and you can very quickly see what you need to get out of that and what your conclusions you’re drawing from it. RR: Yeah, I think it’s that. The difficulty of democratizing data into meaningful, actionable insights is sometimes impossible. You have so much at your disposal, and so making it useful is sometimes a challenge, so I love hearing that. You’re finding a way to use it well and inform your programs well. So we’ve heard a little bit about engaging buyers driving adoption. Tracking your impact and seeing how it’s kind of helping you do the things that you need to. So just one last question for you to close this out. For other enablement leaders looking to improve the buyer experience in today’s very digital first world, what is the biggest advice you would give ’em? AH: Oh, that’s a great question. I would say if you are in a position where you’re fortunate enough to be the buyer, think about how you want to experience that life cycle. You know, as someone who is a buyer day to day, as well as an enabler. You know, I always ask myself through, when we do our methodology onboarding, I will go and speak to the sales people about actually what it’s like from a buyer’s experience today, and that really helps. Give them that insight into what is sometimes a little bit of an elusive world that we know the buyer’s world, the buyer’s experience. So I would say for other enablers is how do you like to speak to your vendors? How often you know, what makes them stand out? What makes them noisy in your inbox, you know? When do you get those emails or outreach that you think, wow, I really wanna continue a conversation with that person. What did that person do? How can you bring that into your go to market? How can you bring that into your sales team if you’re an enabler who is perhaps not in the buying cycle? I would say. Spend time with your salespeople, really understanding the customer experience, and there are many ways that we can do this. Nowadays with technology, obviously everybody’s got call recording software, so we have a lot of our sales calls recorded. If you as an enabler are not digging in and really understanding what’s happening in those customer conversations, it’s going to be harder for yourself to be able to really get into the world of salespeople. So I would say, you know, you really need to experience. What the customer is going through. And that can be simply by having a look at those calls. Where were they successful? Where was there a positive outcome? Where did the buyer enjoy it? But then also where did the buyer sometimes mention things that were pains to them or where they would like to see improvements? What were the questions? That is where we really need our enablers to be on the front foot of really digging into the customer experience and almost spend as much time as you know with your customers, as you do with your salespeople, to really get that insight. RR: I think that’s fantastic advice to close on, is to put yourself in the buyer’s shoes, understand what they’re going through, and know for yourself what good looks like to you and drive that in your own business. So thank you again, Anabel. This has been a wonderful conversation full of all sorts of good insights that I really can’t wait to share with our community. I appreciate you joining us so much. AH: Thank you so much. Thank you so much for having me as well. Fantastic questions. RR: Amazing. Well, to our listeners, thank you for listening to this episode of the Win-Win podcast. Be sure to tune in next time for more insights on how you can maximize enablement successful Highspot.

We've just announced our 2025 B2B Marketing Awards Shortlist, and we are joined by FunnelFuel, Differentiated, Gravity Global and The Croc to break down some of the juicy details behind this year's theme and campaigns. In this podcast episode, we were joined by Sarah Townsend, Head of Growth & Innovation, The Croc; Chris Omotosho, Managing Director, UK, Gravity Global; Paul Collier, CMO, FunnelFuel; and finally last but not least Jon Buckthorp, Commercial Director, Differentiated. The group discussion kicks off with an overarching look at the B2B industry and how it has led to compelling campaigns that are data-back, creative and commercially successful. In addition, they chat about some of the big categories like ‘Best use of AI', ‘Most commercially successful campaign' and ‘Best campaign with a limited budget'. And if you're looking for thought leadership advice throughout, find out the key traits to success; plus, why failing in today's competitive environment can actually be a positive way of upskilling your team. This year's winners will be announced at the B2B Marketing Awards ceremony on 26 November 2025. You can find all the ceremony details and table booking information on the event website: b2bawards.net.

A conversation with Robin, CEO of Raiku, about Raiku's approach to guaranteed transaction includion on Solana.

In this episode, Ken Shuman states that he believes self-differentiation is the last and biggest hurdle in growing in emotional maturity, and it is a really challenging one. He shares a personal story about his own growth in differentiation and then puts forward seven characteristics of highly differentiated people, as growth goals for our journey toward emotional maturity.This episode was recorded on August 22, 2025.

Listen in as Nick is joined by Darren Clifford, the Founder of Adapt [us] Capital, a new venture capital fund and venture builder focused on investing and building companies at the intersection of climate adaptation and scalable, profitable businesses. In this episode, Nick and Darren discuss how the climate change, climate investment, and climate mitigation “moment” in 2025 requires new conversations, narratives, and solutions, including more focus on and concerted capital allocation to promoting adaptation-focused efforts alongside other mitigation strategies and innovation. Nick and Darren also explore: Demand Adaptation vs. Resilience Adaptation: Drawing distinctions between "demand adaptation" (businesses and technologies that profitably fulfill emerging needs in a warming world, like air conditioning, cold supply chains, and climate-resilient vacation options) and "resilience adaptation" (efforts to avert loss, price risk, and enhance society's coping mechanisms).Getting creative on narrative reframes: Darren and Nick reframe prevailing climate narratives, such as "net zero," advocating instead for optimizing humanity's overall quality of life and letting go of concepts and targets that no longer serve. They also discuss the need to balance environmental priorities with social connectivity, economic opportunity, resilient infrastructure, and many other components that ladder up to well-being, recognizing that trade-offs between maximum sustainability and human quality of life are often unavoidable, if not necessary.Venture capital's role in scaling adaptation: Nick prompts Darren to answer the “why venture” question, particularly with respect to how venture capital can support a more focused approach to, resource allocation for, and successful scaling of adaptation-focused businesses. This conversation also explores business model innovation, anticipated market sizes for climate adaptation solutions, and the evolving nature of deal flow in the digital and AI-powered world.… and much more.Timestamps:00:01:37 - Introductions00:05:41 – Distinguishing between demand adaptation and resilience adaptation00:09:25 – Reframing outdated climate narratives like net zero00:15:02 - Sustainability and human quality of life: intersections and trade offs00:26:03 - Fund launch and investment strategy00:28:12 - Market opportunities in demand-driven adaptation00:36:05 - The future of demand-driven adaptationLearn more about Darren's work and keep up to date with Adapt [us] Capital on LinkedIn: https://www.linkedin.com/company/adapt-us-capital/+ https://www.linkedin.com/in/djclif/If you love listening to The Keep Cool Show, please leave a 5-star review on Rate My Podcast: https://ratethispodcast.com/keepcoolThank you so much.Plus, you can stay up-to-date on all things Keep Cool here: https://subscribe.keepcool.co/ and follow Nick on LinkedIn: https://www.linkedin.com/in/nicholasvanosdol/

Why do some students struggle to see math and science as more than just flashcards and formulas? In this episode of Empowering Homeschool Conversations, host Peggy Ployhar talks with Christian mom, certificated physics teacher, and innovative educator Margaret Shawver, who shares how one simple tool—differentiated graph paper—is helping homeschool students understand complex concepts by making them visual, relatable, and even worshipful. Margaret discusses how different brains see the world—from analytical, system-driven thinkers to detail-oriented, story-minded learners—and how connecting prior knowledge to new learning can transform abstract ideas into meaningful insights. She also shares real-world examples, like what peanut butter cups and beehives can teach us about geometry, and how incorporating faith into scientific exploration deepens both learning and wonder. Whether your child is a reluctant math learner or a curious thinker ready to explore God’s creation, this episode will give you practical strategies and a fresh vision for helping your homeschooler thrive in analytical subjects. Topics include: Differentiated graph paper: What it is and why it works Teaching to different learning styles and brain types Bringing faith into STEM learning Making math tangible with everyday objects Encouragement for parents teaching subjects they struggle with To find Margaret's graph paper, visit: https://www.walmart.com/ip/ColorGraph-Differentiated-Graph-Paper-0-25-in-squares-big-size/5401461569?classType=REGULAR&from=/search To learn about the other Empowering Homeschool Conversations Co-Hosts and their resources, visit: https://www.spedhomeschool.com/ https://annieyorty.com/ https://www.leilanimelendez.com/ https://elarplearning.com/ https://solimaracademy.com/ Make sure to subscribe, share and comment! Join our mission to empower homeschool families!: https://spedhomeschool.com/donate/Join our mission to empower homeschool families!: https://spedhomeschool.com/donate/ Discover more Christian podcasts at lifeaudio.com and inquire about advertising opportunities at lifeaudio.com/contact-us.

In this episode of the InsuranceAUM.com Podcast, host Stewart Foley welcomes Dane Graham, Managing Director at 17Capital, for an insightful conversation about the growth and evolution of NAV finance. Dane breaks down what NAV finance is, how it works, and why it's increasingly being considered as a strategic tool for insurers looking to access liquidity while maintaining exposure to private assets. He shares how 17Capital has positioned itself in this space and how NAV-based lending has matured into a more accepted part of the capital stack.   The conversation explores how NAV finance can complement an insurer's investment toolkit—especially in today's environment where flexibility and downside protection are crucial. Dane also discusses the growing demand from institutional investors, the risk considerations, and how insurers can assess whether this approach aligns with their long-term goals. Whether you're new to NAV finance or looking to refine your understanding, this episode offers valuable insights into an innovative and expanding segment of private credit.

We're nearly halfway through the year, and the perfect time to assess your brand positioning. Have you gone off track or do people know what you do and how you're different? In the age of commodization, AI, and attention, it's critical to have the right headspace in your ideal audience's minds.We share tips and our stories of getting back on track so you have a brand that's top of mind and top choice in your field.CONTACT US:Michelle J Raymond is a globally recognized LinkedIn™️ for business growth speaker, author and consultant. Her services – audit & strategy, LinkedIn training and LinkedIn profile rewrites. LinkedIn: ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠https://www.linkedin.com/in/michellejraymond/⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠Website: ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠https://b2bgrowthco.com/⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠Michelle B. Griffin is an international personal branding & PR speaker, strategist, author, podcaster, and LinkedIn® visibility expert. As the founder of Brand Leaders® and the Own Your Lane® Recognition Roadmap, she advises, speaks and trains B2B industry experts to clarify their value, grow strategic visibility, and lead with lasting authority.LinkedIn:⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠https://www.linkedin.com/in/michellebgriffin/⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠Websites: ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠https://michellebgriffin.com⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ and ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠OwnYourLane.io⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠Buy your copy on Amazon- The LinkedIn Branding Book, The Power of Two: Build Your Personal and Business Brand on LinkedIn for Exponential Growth -⁠⁠⁠ ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠https://mybook.to/The_LinkedIn_Branding_Book⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠https://MichelleSquared.com⁠⁠⁠⁠⁠⁠⁠⁠⁠LINKS⁠⁠⁠⁠The LinkedIn Branding Book + Workbook⁠⁠⁠⁠⁠⁠⁠⁠Position Yourself Personal Branding Planner⁠⁠⁠⁠⁠⁠⁠⁠Business Gold: LinkedIn Company Pages⁠⁠⁠⁠SUBMIT YOUR QUESTION:Simply DM both Michelles on LinkedIn to submit your question for a future episode.

Meaningful relationships are mutual. Balanced with give and take, equal influence between partners, and a vibrant dance of loving responsiveness and caring attention.Marriage and Family Therapist and professor Dr. Jessica ChenFeng is calling us toward a more justice-oriented approach to relationships and to mental health and well-being, She invites us to open-hearted and empathic perspective taking, and seeking an integrated wholeness that incorporates all of who we are—highlighting the gift of mutuality in our most intimate relationships in marriage and family life.In this conversation with Jessica ChenFeng, we discuss:The importance of integrated and whole experience of ourselves—allowing racial, gender, and cultural identities to weave together in our sense of vocation and contribution to the worldThe importance of mutuality in relationships—but particularly in marriage and family systems.The ways emotional power flows in a relationship and impacts marriage and family dynamicsThe difference between partners focusing on meeting their individual needs and caring for the health of an intimate relationshipAnd she offers a guided practical exercise to help us lovingly notice and accept our inner experience with a heart open to justice, vulnerability, and the reminder that we are beloved in the eyes of God.Episode Highlights"Systems of power harm everyone—and to live life to the full, we have to see each other fully.""I believe our move toward life to the full requires us to see the world through a third-order lens: not just family systems, but the racial, gender, and societal systems they exist within.""Mutuality means not just expressing our needs but being willing to be changed by the needs of others.""If we're not attuned to the pleasant sensations in our bodies, we miss the invitations to thrive.""Cultural norms are not God-given realities; they are social constructs we are invited to discern and transform.""Knowledge without authentic relationship keeps us from truly seeing the embodied experiences of others."Helpful Links and ResourcesCheck out the programs in Marriage & Family Therapy at Fuller School of Psychology www.fuller.edu/school-of-psychology/Fuller Asian American Center aac.fuller.edu/Socio-Emotional Relationship Therapy (SERT) OverviewCircle of Care Model ExplainedPositive Psychology and EmotionsJeanne Tsai's Research on Culture and EmotionAsian American Values Scale ReferenceRace and Trauma ResourcesJeanne Tsai's research on culture and emotion – Stanford SPARQJohn and Julie Gottman Relationship ResearchAsian American Values Scale – Paniagua & Yamada (Academic resource)Show NotesJessica ChenFeng shares her "yes and" identity as a second-generation Taiwanese American grounded in both math and creativity.How earthy aesthetics and connection to nature shape Jessica's professional and personal flourishing.The integration of Christian faith with clinical work at Fuller Seminary."Seeing systems of systems" — why thriving requires understanding how race, gender, and cultural forces shape individuals and families.Introduction to socio-emotional relationship therapy (SERT) and the value of mutuality in relationships.Defining mutuality: mutual attunement, mutual influence, mutual vulnerability, and mutual relational responsibility."Mutuality asks: Are both people tending to the relationship itself?"Practical signs of mutual and non-mutual relationships, including emotional attunement and willingness to be influenced.The importance of humility and relational awareness in building mutual relationships.The Circle of Care model: cultivating healthy relational dynamics through attunement and responsiveness.Discerning relational power dynamics in marriages, friendships, and work relationships."Thriving is an open heart, even on a stressful day."How emotional self-control in Asian American cultures is often rooted in relational ethics, not personal repression.The risk and gift of navigating cross-generational emotional communication in immigrant families.Differentiated selfhood: balancing authenticity with cultural respect in relational dynamics.Race, culture, and relational healing: why systems of privilege harm everyone."Love your neighbor as yourself" as an ethic for mutual flourishing across racial and cultural difference.Building trust by leaning into discomfort and courageous conversations.The need for embodied encounters with real people beyond theories of race and difference.Mindfulness practice: Jessica leads a guided exercise in attuning to pleasant sensations in the body.The transformational power of positive emotions and embodiment for creativity and resilience.The relational impact of systemic racialization and why "colorblindness" fails to honor real lived experience.Final reflections: How knowing who we are through systemic and relational lenses allows deeper thriving.Pam King's Key TakeawaysEach of us in the human family is a beloved child of God—and we need to continue to shape society to reflect this foundational truth.The path to meaning and fulfillment in a relationship starts with noticing and acknowledging the flow of emotional power, and its destination is mutuality and humilityThriving means incorporating all of who we are—our heritage and histories especially—into our love of ourselves, our love of others, and love of God.Our intimate relationships need care and attention as a third reality beyond our selves and our partners.And finally, thriving means opening our hearts each day, connecting our inner and relational realities, and learning to love patiently the multitudes we all contain.About Jessica ChenFengDr. Jessica ChenFeng is Associate Professor at the School of Psychology & Marriage and Family Therapy at Fuller Seminary, and is also Director of the Asian American Well-being Collaboratory at Fuller's Asian American Center. Prior to her time at Fuller she was a professor at Loma Linda University and California State University, Northridge.Jessica is known for her clinical expertise and scholarship integrating socio-contextual lenses of race, gender, and generation into work with minoritized individuals, families, and communities. In the last few years, her primary clinical focus has been the well-being of physicians, especially through pandemic-related trauma and burnout. She's co-authored two books, Finding Your Voice as a Beginning Marriage and FamilyTherapist, as well as Asian American Identities, Relationships, and Cultural Legacies: Reflections from Marriage and Family Therapists. She received the 2022 American Family Therapy Academy Early Career Award. About the Thrive CenterLearn more at thethrivecenter.org.Follow us on Instagram @thrivecenterFollow us on X @thrivecenterFollow us on LinkedIn @thethrivecenter About Dr. Pam KingDr. Pam King is Executive Director the Thrive Center and is Peter L. Benson Professor of Applied Developmental Science at Fuller School of Psychology & Marriage and Family Therapy. Follow her @drpamking. About With & ForHost: Pam KingSenior Director and Producer: Jill WestbrookOperations Manager: Lauren KimSocial Media Graphic Designer: Wren JuergensenConsulting Producer: Evan RosaSpecial thanks to the team at Fuller Studio and the Fuller School of Psychology & Marriage and Family Therapy.

I'm pulling back the curtain on how I use AI in my work with teachers as an instructional coach. I'll show you how I collaborate with AI to brainstorm ideas, reflect on lesson design, and help teachers build scaffolds and supports that truly meet students where they are. This is an honest, behind-the-scenes look at how educators are already partnering with AI in powerful and practical ways, as well as the limitations of these tools and what's NOT working. You'll learn: What it means to treat AI as a reflective collaborator, not just a resource generator How tools like Diffit, Brisk Teaching, Insta-Lesson, and MagicStudent can support differentiation, feedback, and independent learning Prompts and workflows I use when coaching teachers to personalize tasks without creating extra work Strategies for using AI to scaffold multi-step directions, revise writing, and support executive functioning How to guide students in getting feedback from AI directly and build their independence Get the shareable article/transcript for this episode here. Grab the free AI prompt guide to try these strategies yourself. Sign up for the free live training on June 10th @ 5pm ET. Join the 40 Hour AI membership to get up-to-date trainings. Bring me to your school for customized on-site or virtual PD.

Dr. Kimberly Perez and Dr. Jaydira Del Rivero discuss the new guideline from ASCO on symptom management for well-differentiated GEP-NETs. They share the latest recommendations on managing symptoms related to hormone excess, including carcinoid syndrome and carcinoid heart disease, managing symptoms of functioning pancreatic neuroendocrine tumors, and also palliative interventions. Dr. Perez and Del Rivero share how to use this guideline in concert with the systemic therapy for tumor control in metastatic well-differentiated GEP-NETs guideline, and hope for the future for the treatment of gastroenteropancreatic neuroendocrine tumors. Read the full guideline, “Symptom Management for Well-Differentiated Gastroenteropancreatic Neuroendocrine Tumors: ASCO Guideline.” Transcript This guideline, clinical tools, and resources are available on ASCO.org. Read the full text of the guideline and review authors' disclosures of potential conflicts of interest in JCO Oncology Practice.        Brittany Harvey: Hello and welcome to the ASCO Guidelines Podcast, one of ASCO's podcasts delivering timely information to keep you up to date on the latest changes, challenges, and advances in oncology. You can find all the shows, including this one, at asco.org/podcasts. My name is Brittany Harvey and today I'm interviewing Dr. Kim Perez from Dana-Farber Cancer Institute and Dr. Jaydira Del Rivero from the Center for Cancer Research at the National Cancer Institute, co-chairs on “Symptom Management for Well-Differentiated Gastroenteropancreatic Neuroendocrine Tumors: ASCO Guideline.” Thank you for being here today, Dr. Del Rivero and Dr. Perez. Dr. Kim Perez: Thank you. Dr. Jaydira Del Rivero: Thank you so much for the invitation. Brittany Harvey: And then before we discuss this guideline, I'd like to note that ASCO takes great care in the development of its guidelines and ensuring that the ASCO Conflict of Interest Policy is followed for each guideline. The disclosures of potential conflicts of interest for the guideline panel, including Dr. Perez and Dr. Del Rivero, who have joined us here today, are available online with the publication of the guideline in JCO Oncology Practice, which is linked in the show notes. So then to jump into the content here, first Dr. Del Rivero, could you provide an overview of the scope and purpose of this guideline? Dr. Jaydira Del Rivero: Yeah. Thank you so much. Well, first, we really wanted to thank ASCO for allowing us to develop these guidelines for the management of gastroenteropancreatic neuroendocrine tumors. I do want to mention that there is also another set of guidelines that I was very fortunate also to co-chair with Dr. Perez on the systemic management of gastroenteropancreatic neuroendocrine tumors. But when discussing these guidelines as well as with the different panelists, experts in this type of disease, we also realized that the management of these tumors are quite complex, not only from the management of the disease progression, but at the same time, management of the symptoms related to the hormone excess. And because of that, we like to thank ASCO for allowing us to then not only have a discussion on the systemic management of these tumors, but at the same time develop recommendations for the symptoms related to the different hormones that these neuroendocrine tumors may produce. These guidelines are for the management of grade 1 to grade 3 metastatic gastroenteropancreatic neuroendocrine tumors. These guidelines include the management of the different aspects and the symptoms related to hormone excess, such as carcinoid syndrome, carcinoid heart disease, how to manage carcinoid crisis, as well as the different symptoms and how to manage the functional pancreatic neuroendocrine tumors and as well as provide recommendations in the different treatments for these tumor types, not only from the systemic management but also from the surgical management as well as for liver-directed therapy options and the different aspects in terms of the palliative care of these patients to improve not only the symptoms related to the hormone excess caused by these tumors, but as well as to improve the quality of life. Brittany Harvey: Absolutely. And I appreciate that overview. And yes, we'll link the guideline on the Systemic Therapy for Tumor Control for Well-Differentiated Gastroenteropancreatic Neuroendocrine Tumors in the show notes for our listeners so that they can refer to that companion guideline as well. So then you just described the several different categories of recommendations that this guideline covers on symptom management. So, Dr. Perez, I'd like to start reviewing some of those key recommendations of that guideline. So, starting with what are the key recommendations for carcinoid syndrome and carcinoid heart disease? Dr. Kim Perez: Thank you Brittany. Yeah, I also want to thank ASCO for inviting us to do this podcast today. Just to start, I think these guidelines will really add to what's available in the literature to provide a kind of a quick look for the community provider to manage carcinoid-related symptoms. I think the highlights that I would point out are we've all been using somatostatin analogs for the last few decades to manage symptoms, but with the newer treatments that are now available, we tried to highlight what does the literature support in regards to PRRT, what does the literature support in regards to using systemic therapy for disease management, but also the benefits that you will get from a symptom management perspective using other modalities. I think the highlight really is it's a multidisciplinary approach. We are now considering surgery and embolization or interventional radiology as a critical piece. And I think the third that I'd highlight is the fact that sometimes we get too focused on carcinoid syndrome and the symptoms will actually, may result from other things. And the highlight in the algorithms that we've provided is what other things cause carcinoid-related diarrhea. And let's not forget about that because we will find ourselves treating and patients getting very frustrated with persistence of symptoms when in actuality, we should be treating something else that is causing a very similar symptom. For carcinoid heart disease, I think there are more and more guidelines that are now available to provide guidance there, but I think the major advances are that we should be utilizing heart assessment with echocardiogram with lab values such as BMP. But also critical to this is consulting with our cardiology colleagues and making sure that we're identifying heart related issues that are resulting from hormone excess sooner than later because interventions on the earlier side can really make a significant impact on quality of life and associated comorbidities and mortality. Brittany Harvey: Thank you for reviewing those key points for both carcinoid syndrome and carcinoid heart disease symptom management. So then the next set of recommendations. Dr. Del Rivero, what are the key highlights for symptom management of functioning pancreatic neuroendocrine tumors? Dr. Jaydira Del Rivero: Yes, it's very important to recognize the symptoms related to hormone excess due to pancreas neuroendocrine tumors. Up to 10% of pancreas neuroendocrine tumors may produce different hormones. Among those hormones can be insulin, gastrin, glucagon, somatostatin. So it's important to know and understand that based on what a neuroendocrine tumor is, they may produce different types of hormones. The importance of these guidelines is to also recognize some of these symptoms and how to address that, because it's not necessarily in these tumor types besides the management of metastatic disease, and know the different options that we recommend for metastatic disease from the systemic therapy, such as chemotherapy or targeted therapies or PRRT. It's important to recognize the symptoms because based on the symptoms we may recommend a different approach. That's something that is important to acknowledge and recognize. Moreover, in certain functional pancreas neuroendocrine tumors, as Dr. Perez mentioned, is a multidisciplinary approach. And it's important to also discuss these different cases with your endocrinologist. You may need to have an experienced endocrinologist to manage, for example, the excess of insulin. And also discuss your cases with a surgeon and interventional radiologist because some of these approaches can certainly improve the symptoms related to hormone excess. I understand that sometimes medical oncologists in the communities may not have access to the multidisciplinary approach or have the different teams that can manage these tumors, and that's the reason why with these guidelines we wanted to establish the understanding of different symptoms associated with the hormone excess to these neuroendocrine tumors as well as how to manage this. For example, in the case of insulinoma, I think for the medical oncologist it is important to know that the everolimus is an option to be used for these tumors, not only to manage tumor progressions related to this tumor type at the same time, because everolimus as a side effect causes hyperglycemia, that can also improve some of the symptoms related to the excess of insulin besides the somatostatin agonist. I think these recommendations will allow the medical oncologist to recognize the symptoms and based on what the symptoms cause, then you can have a different approach that could be added to the systemic therapies options as well. Brittany Harvey: Yes, beyond systemic therapy, it's important to be recognizing symptoms to provide an individualized approach for every single patient. So then, following that overview of symptom management for functioning pancreatic neuroendocrine tumors, Dr. Perez, what is recommended regarding palliative interventions for patients with gastroenteropancreatic neuroendocrine tumors? Dr. Kim Perez: Yeah, great question. So I think what's unique to neuroendocrine tumors is that the palliative approach really mirrors what we would be doing for symptom management. Some of these patients are living a very long time with carcinoid related symptoms. And so the approach that we take for the carcinoid symptom control is going to mirror the palliative piece of it. I think for those who develop a burden of disease related symptoms, I think it mirrors what we do across the board for all cancer-related complications. And so I think what we attempted to highlight here and included one of our colleagues who focuses specifically on the field of palliative care and neuroendocrine tumors, was to never really lose sight of what we've been doing to care for symptom management throughout the patient's journey and to always rereview the etiology of the symptoms, ensure that we don't focus solely on carcinoid-related issues, but also the symptom management that we would apply to all patients with cancer-related burden symptoms. Brittany Harvey: Definitely. I think that's a helpful approach to consider when thinking about how to manage these palliative interventions as well. So then Dr. Del Rivero, what should clinicians know as they implement these symptom management recommendations? Dr. Jaydira Del Rivero: Yes, thank you so much for that question. As we have discussed in the last 10 or 15 minutes, we have discussed the different approaches on the management of gastroenteropancreatic neuroendocrine tumors. Clinicians, I think it's important to know that neuroendocrine tumors is a quite complex disease because we're not only addressing the management of tumor growth, but we're also addressing the management of the symptoms related to hormone excess and the complexity associated with that. When medical oncologists or clinicians implement these recommendations it's to understand what symptoms these tumors may cause related to the hormone excess but at the same time, how do we approach those symptoms? As Dr. Perez said that I think is very important is to recognize the different types of diarrhea. It doesn't mean that if the patient has worsening diarrhea, it doesn't mean that this is related to disease progression. So it's important to recognize so that way you can address that, because the type of diarrheas can be related because of the lanreotide or somatostatin agonist, it could be because of the prior surgery. I think it's important to recognize those in order to address the symptom. And the same with the gastroenteropancreatic neuroendocrine tumors. It's important to know what hormones they produce because there are different measurements that may be added to the systemic management of these tumors. I think that there are two aspects here, and that's the reason why these guidelines were implemented in the sense that not only we're going to manage disease progression of these tumors, or how do we manage the metastatic disease of these tumors, but at the same time, how do we manage the symptoms related to the hormone excess and the different complications. Moreover, I think, as we discussed earlier, we need to manage these tumors in a multidisciplinary approach. And something very important is not like one size fits all, because the treatment recommendations, it will depend on different characteristics in terms of the tumor presentations. And hormone excess is one of the important aspects to recognize so that way we can implement these recommendations that will definitely help the quality of life of these patients. Brittany Harvey: Absolutely. And using these guidelines in concert with the systemic therapy guidelines is key. And then beyond this impact for clinicians that Dr. Del Rivero has just outlined, Dr. Perez, what does this new guideline mean for patients with gastroenteropancreatic neuroendocrine tumors? Dr. Kim Perez: Yeah, I think that's an important highlight of this guideline. It really gives patients a voice. I think it recognizes the fact that these symptoms can go unmanaged or mismanaged or just missed, and patients commonly will come in feeling very frustrated and feeling very ill. And I think it will provide them a means to open up a conversation with their providers and say, “Hey, this is what I'm experiencing. Let's talk about what's available. How does this apply to me?” And I think that can be very empowering. I think it's really hard nowadays with so many sources and resources online and patients are really left wondering what are the bullet points that they should be bringing to their clinician appointments? And I think that these guidelines provide them a good framework for those discussions. Brittany Harvey: Yes, bringing these discussion points for patients is very important to be able to have those resources. And we have some patient resources and information available on the website for this guideline and we can link that in the show notes for listeners. So then you've both touched on the importance of this guideline for improving quality of life and we continue to see advancements in this field. So Dr. Del Rivera, what are the outstanding questions regarding symptom management and tumor control for gastroenteropancreatic neuroendocrine tumors? Dr. Jaydira Del Rivero: I have to say whenever somebody asks me that question, the word that I will say is I feel hopeful, because more than 10 years ago we didn't have that many options for gastroenteropancreatic neuroendocrine tumors. And it has been in the last decade or so that there has been more developments in the management of these tumors as well as the understanding of the symptoms related to these tumors. But that said, yes, we do need more therapies for gastroenteropancreatic neuroendocrine tumors. Of the treatment options that we have, we all know in the field that even though we have disease control by using the different options for the systemic management of gastroenteropancreatic neuroendocrine tumors, we need options where we can achieve an objective response, especially for these tumor types. But there is a significant volume of disease and we see a lot of these patients with gastroenteropancreatic neuroendocrine tumors. And now where the field is going is to make some of these therapies more effective, to develop more therapies as well. For example, immunotherapies, a different type of immunotherapy understand the tumor immune microenvironment of these tumors in order to develop therapies as well. From the antibody drug conjugates, I think that's a new way to also address or treat these tumor types, understanding about the different markers found on these tumors that way they can be addressed in different ways. Now with the development of new therapies, I think that's something that can help us as well not only have disease control and as well as having an objective response, but having a better objective response can certainly also help with the symptoms related to hormone excess too. In terms of other therapies, I think some of the issues that we encounter are like the refractory carcinoid diarrhea and how do we manage this. We do have therapies that can help us control the diarrhea in the refractory settings, such as telotristat. Telotristat is one of the newer medications that can help us control the refractory diarrhea. But that said, despite this, that we still encounter situations where it's sometimes difficult to control. I think in those situations it will be good to understand more about the biology of these tumors as well and how we manage. If there is a different time or how do we implement these options. I think there is so much to learn. But that said, I feel we're in hopeful times. We're understanding more about these tumors so that way we can help us develop better therapies not only to have control of the tumor growth as well having control of the symptoms. And it's the same with the pancreas neuroendocrine tumors in the metastatic setting. Sometimes it may be difficult to control this hormone excess. But understanding these and having therapies that can achieve more of an objective response, I think that will definitely help us more and manage these patients. But one aspect I want to mention, and Dr. Perez also mentioned as well, the fact that we have these guidelines that help us understand about the different symptoms related to hormone excess and how to address it, I think is very important because having symptoms related to hormone excess can be detrimental to the quality of life on patients with neuroendocrine tumors that may necessarily be related to disease progression and having this information is so important. And I'm hopeful for the different therapies. There's different clinical trials ongoing for neuroendocrine tumors and especially in the field of PRRT. And a lot of more information will come with the different alpha-PRRT and combination therapy. So more information to come in the next couple of years. So this is, in my opinion, hopeful times for this field. Brittany Harvey: It's great to hear that you're hopeful for all the developments in this field and we'll look forward to the development and discovery of new therapies and further research and then, hopefully incorporate those updates into guidelines in the future. So I want to thank you both so much for your work to develop these guidelines and thank you for your time today. Dr. Del Rivero and Dr. Perez. Dr. Jaydira Del Rivero: Thank you so much for having us. Dr. Kim Perez: Thank you. Brittany Harvey: And thank you to all of our listeners for tuning in to the ASCO Guidelines podcast. To read the full guideline, go to www.asco.org/gastrointestinal-cancer-guidelines. You can also find many of our guidelines and interactive resources in the free ASCO Guidelines app, which is available in the Apple App Store or the Google Play Store. If you have enjoyed what you've heard today, please rate and review the podcast and be sure to subscribe so you never miss an episode.   The purpose of this podcast is to educate and to inform. This is not a substitute for professional medical care and is not intended for use in the diagnosis or treatment of individual conditions. Guests on this podcast express their own opinions, experience, and conclusions. Guest statements on the podcast do not express the opinions of ASCO. The mention of any product, service, organization, activity, or therapy should not be construed as an ASCO endorsement.

This week's scriptures:Psalm 32Luke 15v1-3, 11-32This week Adam explores the idea of oneness and separateness with God being built into the fabric of creation. What if God's desire to leave room for you to decide is real? What if God has an imagination for faithful well-differentiated people?

Lauren Bayne is a personal brand creative director, advising entrepreneurs and executive leaders in building personal brands filled with personality and creating intellectual property that makes her clients money. Coming from the advertising industry, Lauren brings creative expression and pizazz to personal branding that gives her clients confidence to stand out from the crowd with bold and entertaining presence. She specializes in helping entrepreneurs, speakers, coaches, authors, consultants, and professionals express their unique personal brands through distinctive, brag-worthy marketing assets.

Angelo Rufino, Partner and Head of Special Situations in North America and Head of Corporate Special Situations in Europe for Bain Capital, joins Bridget Walsh, EY Global Head of Private Equity. In this episode Angelo shares his insights on the differentiated opportunities for Special Situations investing. 17 mins. The views of third parties set out in this podcast are not necessarily the views of the global EY organization or its member firms. Moreover, they should be seen in the context of the time they were made.

Episode 639: Sam Parr ( https://x.com/theSamParr ) and Shaan Puri ( https://x.com/ShaanVP ) talk to Peter Rahal ( https://x.com/peterrahal ) about starting RXBAR with $10K and selling it for $600M, business ideas he would chase today, plus why he's back with another bar.   — Show Notes:  (0:00) RX Bar's path to $600M (8:32) Branding to solve a problem (14:03) David Protein (16:22) Idea 1: Differentiated vasodilator (27:53) Idea 2: The coffee of sleep (32:28) Idea 3: Continuous Testosterone meter (36:58)Idea 4: New religion  (42:03) Why do this again? (45:28) How to survive the first year after exiting (53:03) How big is David going to get? (56:18) Remote v in-office — Links: • RXBAR - https://www.rxbar.com/ • SCOTT & VICTOR - https://scottandvictor.com/  • David's Protein - https://davidprotein.com/ • Lucy - https://lucy.co/  • Moonbrew - https://moonbrew.co/  • Levels - https://www.levels.com/  — Check Out Shaan's Stuff: Need to hire? You should use the same service Shaan uses to hire developers, designers, & Virtual Assistants → it's called Shepherd (tell ‘em Shaan sent you): https://bit.ly/SupportShepherd — Check Out Sam's Stuff: • Hampton - https://www.joinhampton.com/ • Ideation Bootcamp - https://www.ideationbootcamp.co/ • Copy That - https://copythat.com • Hampton Wealth Survey - https://joinhampton.com/wealth • Sam's List - http://samslist.co/ My First Million is a HubSpot Original Podcast // Brought to you by The HubSpot Podcast Network // Production by Arie Desormeaux // Editing by Ezra Bakker Trupiano

When we think about anxiety, we typically think of something that is generated and felt within an individual. But Murray Bowen, a psychiatrist of the mid-20th century, argued that anxiety was also created by the interactions between individuals and could spread like a contagion in a group, an idea known as "Family Systems Theory."Here to offer an introduction to Family Systems Theory and how its implications extend far beyond the family is Steve Cuss, who is a former hospital chaplain, a pastor, the founder of Capable Life, which offers coaching and consultation, and the author of Managing Leadership Anxiety: Yours and Theirs. Today on the show, Steve and I discuss how individuals in both families and organizations can "infect a situation with [their] own assumptions and expectations" and create a sense of anxiety that permeates a group. Steve unpacks the false needs that create chronic anxiety in an individual, how this anxiety spreads to others, and the unhealthy ways people deal with this tension, including becoming fused together. And we talk about how to put this anxiety back where it belongs, and how a single person can change a group dynamic by differentiating from it and becoming a rooted self.Resources Related to the PodcastMurray BowenA Failure of Nerve: Leadership in the Age of the Quick Fix by Edwin H. FriedmanAoM Article: The 5 Characteristics of Highly Dysfunctional GroupsAoM Article: Becoming a Well-Differentiated LeaderThe Cornerstone Concept by Roberta M. GilbertSunday Firesides: You Are Not Responsible for Other People's FeelingsConnect With Steve CussSteve's website