William A. Richards (Bill) is a psychologist in the Psychiatry Department of the Johns Hopkins University School of Medicine, Bayview Medical Center, a consultant/trainer at sites of psychedelic research internationally, a teacher in the Program of Psychedelic Therapy and Research at the California Institute of Integral Studies, and also a clinician in private practice in Baltimore. His involvement with psilocybin research originated in 1963. From 1967 to 1977, he pursued psychotherapy research with LSD, DPT, MDA, and psilocybin at the Maryland Psychiatric Research Center, including protocols designed to investigate the promise of psychedelic substances in the treatment of alcoholism, depression, narcotic addiction, and psychological distress associated with terminal cancer, and also their use in the training of religious and mental-health professionals. His publications began in 1966 with “Implications of LSD and Experimental Mysticism,”. His book, Sacred Knowledge: Psychedelics and Religious Experiences was released in English by Columbia University Press in 2015 and has since been translated into four additional languages. In this episode, we explore the Use of Psychedelics to treat cancer, addiction, and PTSD. How to prepare for a Psychedelic mind manifestation and spiritual awakening experience in a safe environment also known as a safe container, what the homework and integration look like after the therapy, how to build a trusting relationship first with a therapist prior to the consumption of any psychedelic substances and significance of a giving a red rose at the end of a psychedelic therapy. Please enjoy! Please visit https://nishantgarg.me/podcasts for more info. Follow Nishant: Friday Newsletter: https://garnishant-91f4a.gr8.com/ LinkedIn: https://www.linkedin.com/in/nishant-garg-b7a20339/ Twitter: https://twitter.com/Nishant82638150 Facebook: https://www.facebook.com/NishantMindfulnessMatters/
Thanks for joining me for this weeks episode of One For The Road.This week I'm joined by Author Jenny Valentish.Jenny is an English journalist who moved to Australia 15 years ago and she also writes books. One of them, Woman of Substances, is an addiction memoir that uses her story of drug and alcohol use as a case study from which to explore the ways women experience mental health, trauma, eating disorders and addiction, interviewing neuroscientists, researchers and clinicians.Her latest book, Everything Harder Than Everyone Else: Why Some of Us Push Our Bodies to Extremes, riffs on the idea that there is a fine line between hedonism and endurance. Jenny is also a board director of SMART Recovery in Australia, and while she didn't touch alcohol for eight years, she now drinks in what she calls a sensible way.If you enjoy One For The Road, then click follow to be notified of the release of our next episode.You can also access further content and shows on my Patreon account by clicking the link below.https://www.patreon.com/user?u=62824759&fan_landing=trueIf you want to connect with me via Instagram, you can find me on the instahandle @Soberdave https://www.instagram.com/soberdave/or via my website https://davidwilsoncoaching.com/Provided below are links for services offering additional help and advice, and links for Jenny.Everything Harder Than Everyone ElseWoman of SubstancesJenny's writing coaching Jenny on Instagramhttps://www.wearewithyou.org.uk/https://www.drinkaware.co.uk/advice/alcohol-support-serviceshttps://nacoa.org.uk/https://alcoholchange.org.uk/Show producer- Daniella Attanasio-Martinezhttps://www.grownuphustle.com/Instagram - @GrownupHustle See acast.com/privacy for privacy and opt-out information.
When you hear psychedelic mushrooms you probably think of someone just trying to get a good high. Would you believe they can safely aid in the treatment of mental health conditions? Dr. Olga Chernoloz is a trained neuropharmacologist that specializes in psychoactive compounds. She started her doctor career off working in a mental health hospital with treatment-resistant depressed individuals. She was working with cannabis when she kept seeing research models showing incredible data on psychedelic substance use for mental health treatment. Furthermore, she really wanted to help these people and knew this was something she needed to be a part of. As the Chief Scientific Officer at the Wake Network, Dr. Chernoloz aims to uncover the therapeutic potential of psychedelic substances. They have a facility in Jamaica where they grow the mushrooms and run clinical trials. Dr. Chernoloz is very excited about a micro-dosing trial they have coming up. In micro-dosing, the patient takes just 2-10% of the typical dose. Those suffering from anxiety, depression, or trauma report improvement in mood and a deeper connection to themselves, others, and nature, all without the impairment effects. What You'll Learn: The two main misconceptions around psychedelics What micro-dosing is The difference between natural and synthetic psychedelics How psychedelics can bring a better quality of life to those suffering from anxiety, depression, and trauma. And much more! Favorite Quote: “We are taking up this challenge, we are walking the talk so that we can create this evidence for ourselves, the community, the industry, and for patients.” -Dr. Olga Chernoloz Connect with Dr. Olga: Website Linkedin Instagram Facebook How to Get Involved: Gary Roberts is the founder and CEO of Pure Body Zen, a company based around creating and selling high-quality CBD products that work to heal mind and body alike. Gary considers hemp-based medicine a calling, and his organization, along with the world-class team that runs it, reflects his passion. You can learn more about Pure Body Zen on their site, on LinkedIn and on Instagram. If you enjoyed this episode, don't forget to visit the show on Apple Podcasts and leave a rating and review! We love hearing from you! -- We bring unbiased content from opposing views to give you nothing but the facts about Hemp CBD and Cannabis. Helping people understand the benefits of Hemp CBD and Cannabis, removing the fear of the unknown, and dispelling myths and presenting facts. Are you unsure about Hemp-Derived CBD and Cannabis but are interested in learning more about the benefits of this alternative solution to big pharma? We will step out into the unknown to have a clear understanding of what is and isn't possible with Hemp CBD and Cannabis through success stories about health, business and more.
Hour 2- Ken and Curtis discuss the New York, Boston rivalry and how the Patriots don't have a rivalry with the Jets. The pitching stats for the Astros starters tell an interesting story, See omnystudio.com/listener for privacy information.
Rich talks with retired Drug Enforcement Administration officer, Derek Maltz about the dramatic increase in counterfeit drugs being sold on the black market that contain potentially deadly doses of fentanyl. Maltz talks about how the Chinese underground and Mexican cartels are working in tandem to create a conduit for these deadly narcotics into the United States.Support the show (https://RichardHelppie.com)
This episode of the One Youth program with Rena Noquisi aired on Wednesday 20th October 2021 on One FM 98.5 Shepparton. You can listen live to the One Youth Program Wednesday nights from 5-6pm. Contact the station on email@example.com or (+613) 58313131 https://fm985.com.au/ The ONE FM 98.5 Community Radio podcast page operates under the APRA AMCOS and ACMA license of Goulburn Valley Community Radio Inc. (One FM)Number 1385226/1.). This program is made with thanks to the Community Broadcasting Foundation.
In this week's episode, Casey Scott and Dr. Matt Woolley are joined by Dan Fosmark to talk about growing up in a great household with a loving family but struggling to cope with a couple of shoulder injuries that derailed his hopes of playing football. He also dives into his experience with medications during his time as a collegiate shot-putter while battling depression. Then Dan opens up about dealing with physical ailments following his surgeries and using substances to help numb the pain and the mental struggles he was dealing with at the time. He also describes his experiences with rehab, the feeling of constantly falling short, and the hopelessness that came with being homeless. Lastly, we talk about Dan's recovery and what he's been up to since he's been sober over the past year and a half. See omnystudio.com/listener for privacy information.
Ana Luiza is my guest and we will explain to you how to be sure that your are compliant with CMR substances on your product. CMR will be reviewed during an audit and apparently there were a lot of mistakes. So let's help you to avoid that. The post How to comply with MDR when products contain CMR Substances? appeared first on Medical Device made Easy Podcast.
Sibongile Mofokeng is talking to Mr. Lesiba Solomon Legodi about how to deal with a spouse who is abusing substances. They look at anger management as a subtopic to the theme, and also what does the scripture say.
Durant cet épisode, je discute avec Jonathan Charest, Ph.D, du sommeil en lien avec la performance, le voyagement, le décalage horaire, et les substances illicites. À propos de Jonathan Charest: Jonathan possède un doctorat en psychologie à l'Université Laval qui a donné suite à un internat à l'Université de Tucson en Arizona. Il est directeur de programme du sommeil pour les athlètes ainsi que Spécialiste de la médecine comportementale du sommeil au Centre for Sleep & Human Performance à Calgary avec Dr. Charles Samuels; Membre du comité exécutif de la Société Canadienne de Sommeil depuis 2017; Membre du Task Force de la ville de Calgary pour la santé mentale et le développement d'une ville active 2020-2030. Il a été récemment nommé professeur adjoint en Kinésiologie à l'Université de Calgary et professeur adjoint à l'école de psychologie à l'Université Laval. Pour rejoindre Jonathan et son équipe: https://centreforsleep.com/
Raspberries, ellagic acid reveal benefits in two studies Oregon State University, October 1, 2021. Articles that appeared recently in the Journal of Berry Research report that raspberries and compounds present in the fruit could help support healthy body mass and motor function, including balance, coordination and strength. In one study, Neil Shay and colleagues at Oregon State University fed mice a high fat, high sugar diet plus one of the following: raspberry juice concentrate, raspberry puree concentrate, raspberry fruit powder, raspberry seed extract, ellagic acid (a polyphenol that occurs in a relatively high amount in raspberries), raspberry ketone, or a combination of raspberry ketone and ellagic acid. Additional groups of animals received a high fat, high sugar diet alone or a low fat diet. While mice that received the high fat and sugar diet alone experienced a significant increase in body mass, the addition of raspberry juice concentrate, raspberry puree concentrate or ellagic acid plus raspberry ketone helped prevent this effect. Of note, mice that received raspberry juice concentrate experienced gains similar to those of animals given a low fat diet. "We hope that the findings from this study can help guide the design of future clinical trials," Dr Shay stated. In another study, Barbara Shukitt-Hale, PhD, and her associates at Tufts University's Human Nutrition Research Center on Aging gave 19 month old rats a control diet or a diet enhanced with raspberry extract for 11 weeks. Psychomotor behavior was assessed during week 7 and cognitive testing was conducted during weeks 9-10. Animals that received raspberry performed better on psychomotor coordination and balance, and had better muscle tone, strength and stamina than those that received a control diet. "These results may have important implications for healthy aging," stated Dr Shukitt-Hale. "While further research in humans is necessary, animal model studies are helpful in identifying deficits associated with normal aging." Massage doesn't just make muscles feel better, it makes them heal faster and stronger Harvard University, October 6, 2021 Massage has been used to treat sore, injured muscles for more than 3,000 years, and today many athletes swear by massage guns to rehabilitate their bodies. But other than making people feel good, do these "mechanotherapies" actually improve healing after severe injury? According to a new study from researchers at Harvard's Wyss Institute for Biologically Inspired Engineering and John A. Paulson School of Engineering and Applied Sciences (SEAS), the answer is "yes." Using a custom-designed robotic system to deliver consistent and tunable compressive forces to mice's leg muscles, the team found that this mechanical loading (ML) rapidly clears immune cells called neutrophils out of severely injured muscle tissue. This process also removed inflammatory cytokinesreleased by neutrophils from the muscles, enhancing the process of muscle fiber regeneration. The research is published in Science Translational Medicine. "Lots of people have been trying to study the beneficial effects of massage and other mechanotherapies on the body, but up to this point it hadn't been done in a systematic, reproducible way. Our work shows a very clear connection between mechanical stimulation and immune function. This has promise for regenerating a wide variety of tissues including bone, tendon, hair, and skin, and can also be used in patients with diseases that prevent the use of drug-based interventions," said first author Bo Ri Seo, Ph.D., who is a Postdoctoral Fellow in the lab of Core Faculty member Dave Mooney, Ph.D. at the Wyss Institute and SEAS. Seo and her coauthors started exploring the effects of mechanotherapy on injured tissues in mice several years ago, and found that it doubled the rate of muscle regeneration and reduced tissue scarring over the course of two weeks. Excited by the idea that mechanical stimulation alone can foster regeneration and enhance muscle function, the team decided to probe more deeply into exactly how that process worked in the body, and to figure out what parameters would maximize healing. They teamed up with soft robotics experts in the Harvard Biodesign Lab, led by Wyss Associate Faculty member Conor Walsh, Ph.D., to create a small device that used sensors and actuators to monitor and control the force applied to the limb of a mouse. " The device we created allows us to precisely control parameters like the amount and frequency of force applied, enabling a much more systematic approach to understanding tissue healing than would be possible with a manual approach," said co-second author Christopher Payne, Ph.D., a former Postdoctoral Fellow at the Wyss Institute and the Harvard Biodesign Lab who is now a Robotics Engineer at Viam, Inc. Once the device was ready, the team experimented with applying force to mice's leg muscles via a soft silicone tip and used ultrasound to get a look at what happened to the tissue in response. They observed that the muscles experienced a strain of between 10-40%, confirming that the tissues were experiencing mechanical force. They also used those ultrasound imaging data to develop and validate a computational model that could predict the amount of tissue strain under different loading forces. They then applied consistent, repeated force to injured muscles for 14 days. While both treated and untreated muscles displayed a reduction in the amount of damaged muscle fibers, the reduction was more pronounced and the cross-sectional area of the fibers was larger in the treated muscle, indicating that treatment had led to greater repair and strength recovery. The greater the force applied during treatment, the stronger the injured muscles became, confirming that mechanotherapy improves muscle recovery after injury. But how? Evicting neutrophils to enhance regeneration To answer that question, the scientists performed a detailed biological assessment, analyzing a wide range of inflammation-related factors called cytokines and chemokines in untreated vs. treated muscles. A subset of cytokines was dramatically lower in treated muscles after three days of mechanotherapy, and these cytokines are associated with the movement of immune cells called neutrophils, which play many roles in the inflammation process. Treated muscles also had fewer neutrophils in their tissue than untreated muscles, suggesting that the reduction in cytokines that attract them had caused the decrease in neutrophil infiltration. The team had a hunch that the force applied to the muscle by the mechanotherapy effectively squeezed the neutrophils and cytokines out of the injured tissue. They confirmed this theory by injecting fluorescent molecules into the muscles and observing that the movement of the molecules was more significant with force application, supporting the idea that it helped to flush out the muscle tissue. To pick apart what effect the neutrophils and their associated cytokines have on regenerating muscle fibers, the scientists performed in vitro studies in which they grew muscle progenitor cells (MPCs) in a medium in which neutrophils had previously been grown. They found that the number of MPCs increased, but the rate at which they differentiated (developed into other cell types) decreased, suggesting that neutrophil-secreted factors stimulate the growth of muscle cells, but the prolonged presence of those factors impairs the production of new muscle fibers. "Neutrophils are known to kill and clear out pathogens and damaged tissue, but in this study we identified their direct impacts on muscle progenitor cell behaviors," said co-second author Stephanie McNamara, a former Post-Graduate Fellow at the Wyss Institute who is now an M.D.-Ph.D. student at Harvard Medical School (HMS). "While the inflammatory response is important for regeneration in the initial stages of healing, it is equally important that inflammation is quickly resolved to enable the regenerative processes to run its full course." Seo and her colleagues then turned back to their in vivo model and analyzed the types of muscle fibers in the treated vs. untreated mice 14 days after injury. They found that type IIX fibers were prevalent in healthy muscle and treated muscle, but untreated injured muscle contained smaller numbers of type IIX fibers and increased numbers of type IIA fibers. This difference explained the enlarged fiber size and greater force production of treated muscles, as IIX fibers produce more force than IIA fibers. Finally, the team homed in on the optimal amount of time for neutrophil presence in injured muscle by depleting neutrophils in the mice on the third day after injury. The treated mice's muscles showed larger fiber size and greater strength recovery than those in untreated mice, confirming that while neutrophils are necessary in the earliest stages of injury recovery, getting them out of the injury site early leads to improved muscle regeneration. "These findings are remarkable because they indicate that we can influence the function of the body's immune system in a drug-free, non-invasive way," said Walsh, who is also the Paul A. Maeder Professor of Engineering and Applied Science at SEAS and whose group is experienced in developing wearable technology for diagnosing and treating disease. "This provides great motivation for the development of external, mechanical interventions to help accelerate and improve muscle and tissue healing that have the potential to be rapidly translated to the clinic." The team is continuing to investigate this line of research with multiple projects in the lab. They plan to validate this mechanotherpeutic approach in larger animals, with the goal of being able to test its efficacy on humans. They also hope to test it on different types of injuries, age-related muscle loss, and muscle performance enhancement. "The fields of mechanotherapy and immunotherapy rarely interact with each other, but this work is a testament to how crucial it is to consider both physical and biological elements when studying and working to improve human health," said Mooney, who is the corresponding author of the paper and the Robert P. Pinkas Family Professor of Bioengineering at SEAS. "The idea that mechanics influence cell and tissue function was ridiculed until the last few decades, and while scientists have made great strides in establishing acceptance of this fact, we still know very little about how that process actually works at the organ level. This research has revealed a previously unknown type of interplay between mechanobiology and immunology that is critical for muscle tissue healing, in addition to describing a new form of mechanotherapy that potentially could be as potent as chemical or gene therapies, but much simpler and less invasive," said Wyss Founding Director Don Ingber, M.D., Ph.D., who is also the Judah Folkman Professor of Vascular Biology at (HMS) and the Vascular Biology Program at Boston Children's Hospital, as well as Professor of Bioengineering at SEAS. Vitamin E could help protect older men from pneumonia University of Helsinki (Finland), October 7 2021. An article that appeared in Clinical Interventions in Aging reported a protective role for vitamin E against pneumonia in older men. For the current investigation, Dr Harri Hemilä of the University of Helsinki, Finland analyzed data from the Alpha-Tocopherol Beta-Carotene (ATBC) Cancer Prevention Study conducted in Finland. The trial included 29,133 men between the ages of 50 to 69 years who smoked at least five cigarettes daily upon enrollment. Participants received alpha tocopherol (vitamin E), beta carotene, both supplements, or a placebo for five to eight years. The current study was limited to 7,469 ATBC participants who started smoking at age 21 or older. Among this group, supplementation with vitamin E was associated with a 35% lower risk of developing pneumonia in comparison with those who did not receive the vitamin. Light smokers who engaged in leisure time exercise had a 69% lower risk compared with unsupplemented members of this subgroup. The risk in this subgroup of developing pneumonia by age 74 was 12.9%. Among the one-third of the current study's population who quit smoking for a median period of two years, there was a 72% lower risk of pneumonia in association with vitamin E supplementation. In this group, exercisers who received vitamin E experienced an 81% lower pneumonia risk. Dr Hemilä observed that the benefit for vitamin E in this study was strongest for older subjects—a group at higher risk of pneumonia. "The current analysis of individual-level data suggests that trials on vitamin E and pneumonia on nonsmoking elderly males are warranted," he concluded. Toxic fatty acids to blame for brain cell death after injury New York University, October 7, 2021 Cells that normally nourish healthy brain cells called neurons release toxic fatty acids after neurons are damaged, a new study in rodents shows. This phenomenon is likely the driving factor behind most, if not all, diseases that affect brain function, as well as the natural breakdown of brain cells seen in aging, researchers say. Previous research has pointed to astrocytes—a star-shaped glial cell of the central nervous system—as the culprits behind cell death seen in Parkinson's disease and dementia, among other neurodegenerative diseases. While many experts believed that these cells released a neuron-killing molecule to "clear away" damaged brain cells, the identity of this toxin has until now remained a mystery. Led by researchers at NYU Grossman School of Medicine, the new investigation provides what they say is the first evidence that tissue damage prompts astrocytes to produce two kinds of fats, long-chain saturated free fatty acids and phosphatidylcholines. These fats then trigger cell death in damaged neurons, the electrically active cells that send messages throughout nerve tissue. Publishing Oct. 6 in the journal Nature, the study also showed that when researchers blocked fatty acid formation in mice, 75 percent of neurons survived compared with 10 percent when the fatty acids were allowed to form. The researchers' earlier work showed that brain cells continued to function when shielded from astrocyte attacks. "Our findings show that the toxic fatty acids produced by astrocytes play a critical role in brain cell death and provide a promising new target for treating, and perhaps even preventing, many neurodegenerative diseases," says study co-senior author Shane Liddelow, Ph.D. Liddelow, an assistant professor in the Department of Neuroscience and Physiology at NYU Langone Health, adds that targeting these fats instead of the cells that produce them may be a safer approach to treating neurodegenerative diseasesbecause astrocytes feed nerve cells and clear away their waste. Stopping them from working altogether could interfere with healthy brain function. Although it remains unclear why astrocytes produce these toxins, it is possible they evolved to destroy damaged cells before they can harm their neighbors, says Liddelow. He notes that while healthy cells are not harmed by the toxins, neurons become susceptible to the damaging effects when they are injured, mutated, or infected by prions, the contagious, misfolded proteins that play a major role in mad cow disease and similar illnesses. Perhaps in chronic diseases like dementia, this otherwise helpful process goes off track and becomes a problem, the study authors say. For the investigation, researchers analyzed the molecules released by astrocytes collected from rodents. They also genetically engineered some groups of mice to prevent the normal production of the toxic fats and looked to see whether neuron death occurred after an acute injury. "Our results provide what is likely the most detailed molecular map to date of how tissue damage leads to brain cell death, enabling researchers to better understand why neurons die in all kinds of diseases," says Liddelow, also an assistant professor in the Department of Ophthalmology at NYU Langone. Liddelow cautions that while the findings are promising, the genetic techniques used to block the enzyme that produces toxic fatty acids in mice are not ready for use in humans. As a result, the researchers next plan is to explore safe and effective ways to interfere with the release of the toxins in human patients. Liddelow and his colleagues had previously shown these neurotoxic astrocytes in the brains of patients with Parkinson's, Huntington's disease, and multiple sclerosis, among other diseases. Clinical trial for nicotinamide riboside: Vitamin safely boosts levels of important cell metabolite linked to multiple health benefits University of Iowa Health Care, October 3, 2021 In the first controlled clinical trial of nicotinamide riboside (NR), a newly discovered form of Vitamin B3, researchers have shown that the compound is safe for humans and increases levels of a cell metabolite that is critical for cellular energy production and protection against stress and DNA damage. Studies in mice have shown that boosting the levels of this cell metabolite -- known as NAD+ -- can produce multiple health benefits, including resistance to weight gain, improved control of blood sugar and cholesterol, reduced nerve damage, and longer lifespan. Levels of NAD+ diminish with age, and it has been suggested that loss of this metabolite may play a role in age-related health decline. These findings in animal studies have spurred people to take commercially available NR supplements designed to boost NAD+. However, these over-the-counter supplements have not undergone clinical trials to see if they work in people. The new research, reported in the journal Nature Communications, was led by Charles Brenner, PhD, professor and Roy J. Carver Chair of Biochemistry at the University of Iowa Carver College of Medicine in collaboration with colleagues at Queens University Belfast and ChromaDex Corp. (NASDAQ: CDXC), which supplied the NR used in the trial. Brenner is a consultant for ChromaDex. He also is co-founder and Chief Scientific Adviser of ProHealthspan, which sells NR supplements under the trade name Tru NIAGEN®. The human trial involved six men and six women, all healthy. Each participant received single oral doses of 100 mg, 300 mg, or 1,000 mg of NR in a different sequence with a seven-day gap between doses. After each dose, blood and urine samples were collected and analyzed by Brenner's lab to measure various NAD+ metabolites in a process called metabolomics. The trial showed that the NR vitamin increased NAD+ metabolism by amounts directly related to the dose, and there were no serious side effects with any of the doses. "This trial shows that oral NR safely boosts human NAD+ metabolism," Brenner says. "We are excited because everything we are learning from animal systems indicates that the effectiveness of NR depends on preserving and/or boosting NAD+ and related compounds in the face of metabolic stresses. Because the levels of supplementation in mice that produce beneficial effects are achievable in people, it appears than health benefits of NR will be translatable to humans safely." The next step will be to study the effect of longer duration NR supplementation on NAD+ metabolism in healthy adults, but Brenner also has plans to test the effects of NR in people with diseases and health conditions, including elevated cholesterol, obesity and diabetes, and people at risk for chemotherapeutic peripheral neuropathy. Prior to the formal clinical trial, Brenner conducted a pilot human study -- on himself. In 2004, he had discovered that NR is a natural product found in milk and that there is pathway to convert NR to NAD+ in people. More than a decade of research on NR metabolic pathways and health effects in mice and rats had convinced him that NR supplementation had real promise to improve human health and wellness. After consulting with UI's institutional review board, he conducted an experiment in which he took 1 gram of NR once a day for seven days, and his team analyzed blood and urine samples using mass spectrometry. The experiment showed that Brenner's blood NAD+ increased by about 2.7 times. In addition, though he reported immediate sensitivity to flushing with the related compound niacin, he did not experience any side effects taking NR. The biggest surprise from his metabolomic analysis was an increase in a metabolite called NAAD, which was multiplied by 45 times, from trace levels to amounts in the micromolar range that were easily detectable. "While this was unexpected, I thought it might be useful," Brenner says. "NAD+ is an abundant metabolite and it is sometimes hard to see the needle move on levels of abundant metabolites. But when you can look at a low-abundance metabolite that goes from undetectable to easily detectable, there is a great signal to noise ratio, meaning that NAAD levels could be a useful biomarker for tracking increases in NAD+ in human trials." Brenner notes this was a case of bidirectional translational science; having learned something from the initial human experiment, his team was able to return to laboratory mice to explore the unexpected NAAD finding in more detail. Brenner's mouse study showed that NAAD is formed from NR and confirmed that NAAD levels are a strong biomarker for increased NAD+ metabolism. The experiments also revealed more detail about NAD+ metabolic pathways. In particular, the researchers compared the ability of all three NAD+ precursor vitamins -- NR, niacin, and nicotinamide -- to boost NAD+ metabolism and stimulate the activity of certain enzymes, which have been linked to longevity and healthbenefits. The study showed for the first time that oral NR is superior to nicotinamide, which is better than niacin in terms of the total amount of NAD+ produced at an equivalent dose. NR was also the best of the three in stimulating the activity of sirtuin enzymes. However, in this case, NR was the best at stimulating sirtuin-like activities, followed by niacin, followed by nicotinamide. The information from the mouse study subsequently helped Brenner's team design the formal clinical trial. In addition to showing that NR boosts NAD+ in humans without adverse effects, the trial confirmed that NAAD is a highly sensitive biomarker of NAD+ supplementation in people. "Now that we have demonstrated safety in this small clinical trial, we are in a position to find out if the health benefits that we have seen in animals can be reproduced in people," says Brenner, who also is co-director of the Obesity Research and Education Initiative, professor of internal medicine, and a member of the Fraternal Order of Eagles Diabetes Research Center at the UI. Protecting the ozone layer is delivering vast health benefits Montreal Protocol will spare Americans from 443 million skin cancer cases National Center for Atmospheric Research, October 7, 2021 An international agreement to protect the ozone layer is expected to prevent 443 million cases of skin cancer and 63 million cataract cases for people born in the United States through the end of this century, according to new research. The research team, by scientists at the National Center for Atmospheric Research (NCAR), ICF Consulting, and U.S. Environmental Protection Agency (EPA), focused on the far-reaching impacts of a landmark 1987 treaty known as the Montreal Protocol and later amendments that substantially strengthened it. The agreement phased out the use of chemicals such as chlorofluorocarbons (CFCs) that destroy ozone in the stratosphere. Stratospheric ozone shields the planet from harmful levels of the Sun's ultraviolet (UV) radiation, protecting life on Earth. To measure the long-term effects of the Montreal Protocol, the scientists developed a computer modeling approach that enabled them to look to both the past and the future by simulating the treaty's impact on Americans born between 1890 and 2100. The modeling revealed the treaty's effect on stratospheric ozone, the associated reductions in ultraviolet radiation, and the resulting health benefits. In addition to the number of skin cancer and cataract cases that were avoided, the study also showed that the treaty, as most recently amended, will prevent approximately 2.3 million skin cancer deaths in the U.S. “It's very encouraging,” said NCAR scientist Julia Lee-Taylor, a co-author of the study. “It shows that, given the will, the nations of the world can come together to solve global environmental problems.” The study, funded by the EPA, was published in ACS Earth and Space Chemistry. NCAR is sponsored by the National Science Foundation. Mounting concerns over the ozone layer Scientists in the 1970s began highlighting the threat to the ozone layer when they found that CFCs, used as refrigerants and in other applications, release chlorine atoms in the stratosphere that set off chemical reactions that destroy ozone. Concerns mounted the following decade with the discovery of an Antarctic ozone hole. The loss of stratospheric ozone would be catastrophic, as high levels of UV radiation have been linked to certain types of skin cancer, cataracts, and immunological disorders. The ozone layer also protects terrestrial and aquatic ecosystems, as well as agriculture. Policy makers responded to the threat with the 1987 Montreal Protocol on Substances that Deplete the Ozone Layer, in which nations agreed to curtail the use of certain ozone-destroying substances. Subsequent amendments strengthened the treaty by expanding the list of ozone-destroying substances (such as halons and hydrochlorofluorocarbons, or HCFCs) and accelerating the timeline for phasing out their use. The amendments were based on Input from the scientific community, including a number of NCAR scientists, that were summarized in quadrennial Ozone Assessment reports. To quantify the impacts of the treaty, the research team built a model known as the Atmospheric and Health Effects Framework. This model, which draws on various data sources about ozone, public health, and population demographics, consists of five computational steps. These simulate past and future emissions of ozone-destroying substances, the impacts of those substances on stratospheric ozone, the resulting changes in ground-level UV radiation, the U.S. population's exposure to UV radiation, and the incidence and mortality of health effects resulting from the exposure. The results showed UV radiation levels returning to 1980 levels by the mid-2040s under the amended treaty. In contrast, UV levels would have continued to increase throughout this century if the treaty had not been amended, and they would have soared far higher without any treaty at all. Even with the amendments, the simulations show excess cases of cataracts and various types of skin cancer beginning to occur with the onset of ozone depletion and peaking decades later as the population exposed to the highest UV levels ages. Those born between 1900 and 2040 experience heightened cases of skin cancer and cataracts, with the worst health outcomes affecting those born between about 1950 and 2000. However, the health impacts would have been far more severe without the treaty, with cases of skin cancer and cataracts rising at an increasingly rapid rate through the century. “We peeled away from disaster,” Lee-Taylor said. “What is eye popping is what would have happened by the end of this century if not for the Montreal Protocol. By 2080, the amount of UV has tripled. After that, our calculations for the health impacts start to break down because we're getting so far into conditions that have never been seen before.” The research team also found that more than half the treaty's health benefits could be traced to the later amendments rather than the original 1987 Montreal Protocol. Overall, the treaty prevented more than 99% of potential health impacts that would have otherwise occurred from ozone destruction. This showed the importance of the treaty's flexibility in adjusting to evolving scientific knowledge, the authors said. The researchers focused on the U.S. because of ready access to health data and population projections. Lee-Taylor said that the specific health outcomes in other countries may vary, but the overall trends would be similar. “The treaty had broad global benefits,” she said. What is Boron? The trace mineral boron provides profound anti-cancer effects, in addition to maintaining stronger bones. Life Extension, September 2021 Boron is a trace mineral found in the earth's crust and in water. Its importance in human health has been underestimated. Boron has been shown to have actions against specific types of malignancies, such as: Cervical cancer: The country Turkey has an extremely low incidence of cervical cancer, and scientists partially attribute this to its boron-rich soil.1 When comparing women who live in boron-rich regions versus boron-poor regions of Turkey, not a single woman living in the boron-rich regions had any indication of cervical cancer.2(The mean dietary intake of boron for women in this group was 8.41 mg/day.) Boron interferes with the life cycle of the human papillomavirus (HPV), which is a contributing factor in approximately 95% of all cervical cancers.1 Considering that HPV viruses are increasingly implicated in head and neck cancers,3,4 supplementation with this ultra-low-cost mineral could have significant benefits in protecting against this malignancy that is increasing in prevalence. Lung cancer: A study conducted at the University of Texas MD Anderson Cancer Center between 1995 and 2005 found that increased boron intake was associated with a lower risk of lung cancer in postmenopausal women who were taking hormone replacement therapy. Prostate cancer: Studies point to boron's ability to inhibit the growth and spread of prostate cancer cells. In one study, when mice were exposed to boric acid, their tumors shrank by as much as 38%.6 One analysis found that increased dietary boron intake was associated with a decreased risk of prostate cancer.7 Several human and animal studies have confirmed the important connection between boron and bone health. Boron prevents calcium loss,8 while also alleviating the bone problems associated with magnesium and vitamin D deficiency.9 All of these nutrients help maintain bone density. A study in female rats revealed the harmful effects a deficiency in boron has on bones, including:10 Decreased bone volume fraction, a measure of bone strength, Decreased thickness of the bone's spongy inner layer, and Decreased maximum force needed to break the femur. And in a study of post-menopausal women, supplementation with3 mg of boron per day prevented calcium loss and bone demineralization by reducing urinary excretion of both calcium and magnesium.8 In addition to its bone and anti-cancer benefits, there are nine additional reasons boron is an important trace mineral vital for health and longevity. It has been shown to:1 Greatly improve wound healing, Beneficially impact the body's use of estrogen, testosterone, and vitamin D, Boost magnesium absorption, Reduce levels of inflammatory biomarkers, such as high-sensitivity C-reactive protein (hs-CRP) and tumor necrosis factor α (TNF-α), Raise levels of antioxidant enzymes, such as superoxide dismutase (SOD), catalase, and glutathione peroxidase, Protect against pesticide-induced oxidative stress and heavy-metal toxicity, Improve the brain's electrical activity, which may explain its benefits for cognitive performance, and short-term memory in the elderly, Influence the formation and activity of key biomolecules, such as S-adenosyl methionine (SAM-e) and nicotinamide adenine dinucleotide (NAD+), and Potentially help ameliorate the adverse effects of traditional chemotherapeutic agents. Because the amount of boron varies in the soil, based on geographical location, obtaining enough boron through diet alone can be difficult. Supplementing with low-cost boron is an effective way to maintain adequate levels of this overlooked micronutrient.
Maybe.. but most likely no. Today I discuss how I've seen so many people recovery like a boss only to find themselves binging like there's no tomorrow after reintroducing alcohol into the mix again. We take a look at whether you should pause substances while recovering, whether you'll every be able to have substances ever again, and whether you can live a full life without them. Free Group Coaching: https://mailchi.mp/c705125deeef/groupcoaching Group Coaching Program https://binge-breakers-recovery-course.mykajabi.com/OctoberProgram Webinar Replay Sign Up https://mailchi.mp/597e09efdef2/7yayn5rfnq Work With Me https://www.bingebreakers.com/workwithme-copy Follow Me on Instagram: https://www.instagram.com/bingebreakers/ DISCLAIMER This recording is not intended to be utilized as medical advice or a medical diagnosis. If you think you are in need of medical attention or treatment, please seek it immediately. This recording is intended to offer advice to those struggling with bulimia based on my own experience, my clients experiences, and what I've found to work. This recording will also contain sensitive subjects such as binging and purging, weight, & depression. Please listen at your own discretion and do what you think is best for you. I am a coach. Not a doctor, therapist, or any other medical professional. I cannot diagnose conditions or prescribe treatments. If you think you need more advanced help, such as therapy, ED treatment, or you are a risk to your own health, please seek it immediately. To find more resources on eating disorders please visit: https://www.nationaleatingdisorders.org/help-support/contact-helpline
Aujourd'hui, Elliot piège Samir... qui a sûrement abusé de substances illicites ! Retrouvez Bruno sur Fun Radio avec Bruno Guillon, Christina, Pino, Karina, Maurine, Elliot et Mikka sur Funradio.fr et sur l'application Fun Radio.
We learn about the new Center for Research in Psychoactive Substances at UW-Madison. Then, a new report shows fewer students are filling out a key financial aid form. We find out what that could mean for college enrollment. We look at five things to do this month in Milwaukee. Plus, learn about the career and legacy of South Milwaukee native, and pro-wrestler, “Da Crusher.”
Jenny Valentish has been devoted to dancing around the void for many decades, first in the pub and then the boxing ring as a kickboxer. Jenny is the author of the acclaimed Woman of Substance: A Journey into Addiction and Treatment and her new book, Everything Harder Than Everyone Else: Why Some of Us Push Our Bodies to Extremes. About the book: There is a part of human nature compelled to test our own limits. But what happens when this part comes to define us? When journalist Jenny Valentish wrote Woman of Substances, a book about addiction, she noticed that people who treated drug-taking like an Olympic sport would often hurl themselves into a pursuit like marathon running upon giving up. What stayed constant was the need to push their boundaries. Everything Harder Than Everyone Else follows people doing the things that most couldn't, wouldn't or shouldn't. By delving into their extreme behaviour, theres a lot that us mere mortals can learn about the human condition. The athlete using childhood adversity as grist for the mill. The wrestler turning restlessness into curated ultraviolence. The bare-knuckle boxer whose gnarliest opponent is her ego. The dancer who could not separate her identity from her practice until at deaths door. The bodybuilder exacting order on a life that was once chaotic. And the porn star-turned-fighter for whom sex and violence are two sides of the same coin. Their insights lead Jenny on a compulsive, sometimes reckless journey of immersion journalism. * CONTENT WARNING - Drugs, Sex, Self Harm, Cutting Weight, Eating Disorders, Obsession, Suffering, Addiction. New episodes of the Tough Girl Podcast go live every Tuesday and Thursday at 7am UK time - Make sure you hit the subscribe button so you don't miss out. The Tough Girl Podcast is sponsorship and ad free thanks to the monthly financial support of patrons. To find out more about supporting your favourite podcast and becoming a patron please check out www.patreon.com/toughgirlpodcast. Show notes Who is Jenny? Growing up in Slough Being a journalist and an author Writing her 4th book - Everything Harder Than Everyone Else Being interested in the mental side of endurance Her starting point for the book The link between addiction and endurance racing Asking the question - how far can I push myself Pushing your body to the extreme The anticipation of entering a race and the anticipation of getting a drug to get high Getting a sense of validation from other people Why balance is over rated? Having obsessions from childhood How her obsessions changed when she got into her teens and early twenties Finding kickboxing, and training 5x a week Finding a positive obsession Starting to research the book Finding people who would trust her Why am I doing this thing - which puts a lot of pressure on my body? Super elite athletes and their link to past suffering in childhood The Dark Side of Top Level Sport: An Autobiographic Study of Depressive Experiences in Elite Sport Performers Suffering as an adult athlete and being able to push through the pain Why certain sports attract certain personalities The rise of women taking up strength sports The feeling of POWER and women wanting to take up physical space Social Media Project - #YouLookLikeAMan Her journey in kickboxing Taking on her first amateur fight What it was like being in the ring…. The fear of getting back into the ring Wanting to be a threat in the ring The ability to suffer Learning How to Suffer with the Queen of Pain: My Conversation With OCR Super-athlete Amelia Boone Over exercising and using sport as a way to sanction diet and what you consume The Recovery I needed - By Amelia Boone Book: Women of Substance: A Journey Into Drugs, Alcohol and Treatment Self care? Knowing your Why The next book! Social Media Website: www.jennyvalentish.com Instagram: @jennyvalentish_public Twitter: @JennyValentish
What does a bareknuckle boxer, porn star, BDSM dominatrix, ballet dancer, ultra runner, wrestler, flesh-hook suspension artist and MMA fighter have in common? Push themselves to extremes. If you've dipped your toes (and by that I mean fully immersed yourself) in any of the above, you're likely going to relate to this episode. Jenny Valentish writes for The Guardian, the ABC, The Age and The Monthly. Her third book, Woman of Substances, was a memoir-research hybrid that wound up on university reading lists and became a bible for therapists and ailing hedonists alike. Her latest book, Everything Harder Than Everyone Else interrogates people who push themselves to extremes to mine their hard-won wisdom. EPISODE SPONSOR | SAFIE Website: https://safie.com.au JENNY VALENTISH Website: https://jennyvalentish.com TIFFANEE COOK Linktree: https://linktr.ee/rollwiththepunches Website: www.rollwiththepunches.com.au LinkedIn: www.linkedin.com/in/tiffaneecook/ Facebook: www.facebook.com/rollwiththepunchespodcast Instagram: www.instagram.com/rollwiththepunches_podcast Instagram: www.instagram.com/tiffaneeandco --- Send in a voice message: https://anchor.fm/roll-withthepunches/message
Following a national outcry over the ousting of Sha'Carri Richardson from the Tokyo Olympics, the World Anti-Doping Agency has decided to reconsider its stance on the substance that got Richardson banned. See omnystudio.com/listener for privacy information.
This week we take a look at comments the Senate received on their draft bill to legalize cannabis, and then we'll look at the latest news from the drug czar's office reducing the hurdles for psilocybin research, and why Washington State's Attorney General is suing the DEA along with patients who want to use these “magic” mushrooms, at the end of their life. We'll be discussing all these stories and more on the BEST cannabis podcast in the business... As we like to say around here, “Everyone knows what happened in marijuana today, but you need to know what's happening in Marijuana Tomorrow!” ----more---- Segment 1 - Look Who's Commenting on the Draft Senate Bill to Federally Legalize Cannabis Segment 2: Right to Try Schedule 1 Substances in Court and Loosening Research Restrictions https://www.marijuanamoment.net/washington-officials-join-cancer-patients-in-federal-court-argument-pushing-dea-to-allow-psilocybin-access/ https://www.marijuanamoment.net/bidens-drug-czar-wants-to-make-it-easier-to-research-marijuana-psychedelics-and-other-schedule-i-substances/----more----This episode of Marijuana Tomorrow is brought to you by Cannabeta Realty.
The Japanese government has now joined tens of thousands of doctors and scientists warning that the global Covid-19 vaccine program is really a deadly bioweapon in disguise!Also, Dr. Judy Mikovits will join the broadcast live-on-air to lay out Big Pharma's real agenda and how to stop them.
Episode NotesPODCAST INFOA new podcast episode drops every OTHER MondayMusic credit: L-Ray Music, Courtesy of Shutterstock, Inc.Learn more about your host, Cordelia, by clicking hereBe sure to follow Cordelia on Instagram: @codependentrecovery---------WORKBOOK + COMMUNITY + RESOURCESAre you going through a breakup or divorce? Here is the link to the 98-page workbook. Print version + ebook version available worldwide.Check out Cordelia's book recommendations hereDisclosure: Cordelia is an affiliate of Bookshop.org and she will earn a commission if you click through and make a purchase.Want to join the community (i.e., community club or book club)? Click hereWant access to free resources? Click hereInterested in any other affiliate links? Click hereNote: affiliate links mean Cordelia earns a commission if you click through and make a purchase.---SPONSOR INFO: IRON DOGGYDisclosure: Cordelia will earn a commission if you click on the link & make a purchase.I love their hands-free leashes. You can use them for walking or running. I have two dogs, and they are awesome for taking my dogs around. These are the leashes I have for my two dogs. I bought these before I ever had a podcast or an Instagram.Use the code Heal10 on any links below for 10% off!These are the leashes I use for my dogs:Runner's Choice Hands-Free Dog Leash (with Belt)Extra Leash (w/o Belt)CarabinerOr, here is my general link as well: Click here to explore Iron Doggy website---SPONSOR INFO: EMBARK (DOG DNA TESTING KITS)Disclosure: Cordelia will earn a commission if you click on the link & make a purchase.I recently did these on my dog, and I paid for them on my own. I thought it was such a cool process, and I was so excited at the opportunity to partner with them.Key things to know:Results generally back in 2-4 weeksTests more breeds than any other test, over 350 breeds, types, and varieties, and even includes wolf, coyote, and village dog ancestry - together these breeds cover over 98% of dogs in AmericaMost accurate dog DNA test on the marketThe Breed + Health Test: tests for 200+ health risksAnalyzes over 200K genetic markersWorld's only canine DNA relative finderUse links below:Embark Breed & Health Kit - use code SPRING50 for an additional $50 offEmbark Breed Identification Kit
In this episode we're going to understand how to break free from our attachments so that we can raise our vibration naturally. Get Your 20% Organifi Discount: https://www.organifi.com/aaron Join HighViber today to access FREE meditations, live activations and workshops at: https://www.highviber.com/ Join the 21 Day Raise Your Love Vibration Challenge to get rid of love blocks and become a more magnetic version of you in less than 21 days: http://AaronDoughty.com/Love Instagram: https://instagram.com/aaron_doughty44/ Youtube: https://www.youtube.com/c/AaronDoughty44 Subscribe to the Aaron Doughty Podcast with Aaron Doughty iTunes | https://aarondoughty.com/the-daily-vortex-podcast-itunes Spotify | https://aarondoughty.com/the-daily-vortex-podcast-spotify Stitcher | https://aarondoughty.com/the-daily-vortex-podcast-stitcher
Host: Brenda Zane, www.brendazane.comGuest: Casey Davidson, Hello Someday Coaching and Podcast HostShow notes: www.brendazane.com/hopestream/74Free e-book: www.brendazane.com/hindsightThe Stream, a community for moms: www.thestreamcommunity.comRestoration Mom Retreat (San Diego, Sept. 30 - Oct. 3)This episode explores the sometimes uncomfortable topic of parents' drinking when they have a son or daughter struggling with substances, and provides non-judgmental information and ideas on how to make a change if you decide it's something you want to try.After exploring this topic personally during COVID, I decided to cut alcohol from my diet. In this episode, I share the impact it had on my life, the reasons why it's important to examine the role of alcohol in the parenting process, and tips for making change.My guest is Casey Davidson, host of the Hello Someday podcast and life/sober coach to busy women who want to drink less and live more. Casey's work helped me make the decision to quit and I asked her to share information many of us don't know and how to embark on an alcohol-free life in a culture that glamorizes and celebrates drinking. If this is an area you've been meaning to explore, or even if you're rolling your eyes thinking, "who in the world quits drinking?!"...this is your episode. It'll help you completely reframe how you think about alcohol's role in your life, how it may be impacting your emotional regulation, and how this important change can be a big step in role-modeling healthy behavior and coping skills for your children.
Who can forget these memorable moments in sports when reigning world champions lost their titles, medals, and invitations to compete as punishment for testing positive for performance enhancing drugs. But while most sports experts agree these high-profile scandals represent just the tip of the iceberg, some say the time has come to accept that doping is part and parcel of the spectacle of elite sport. They argue that the days where athletes won medals based on natural genetic advantage and dedicated training are long gone and that the World Anti Doping Administration's push for clean athletes is wishful fantasy. The future of sport is one where athletes will push their physiological boundaries with the help of steroids, hormones, and yes even gene editing, embracing the high-tech innovation that is revolutionizing every other aspect of our lives. Anti-doping crusaders respond that a sporting world that allows unrestricted access to performance enhancement drugs is one that threatens athletes' lives and also spells the end of sport as we have played and watched it for thousands of years. They argue that the most powerful reason to ban doping is that it undermines the skill development and overcoming of physical and mental obstacles that lies at the heart of fair play. Substances that provide immediate athletic advantages without any work or struggle represents the beginning of a joyless and pointless brave new world in sports. Arguing for the motion is Julian Savulescu, Uehiro Chair in Practical Ethics at the University of Oxford, where he directs the Oxford Uehiro Centre for Practical Ethics and Wellcome Centre for Ethics and Humanities. Arguing against the motion is Angela Schneider, Director of the International Centre for Olympic Studies, an Associate Professor in Kinisiology at the University of Western Ontario, and an Olympic silver medallist in rowing. Sources: BBC Sport, ABC News, Huff Post, CNBC, TNW, Calgary Herald, NBC, Channel 4, City News The host of the Munk Debates is Rudyard Griffiths - @rudyardg. Tweet your comments about this episode to @munkdebate or comment on our Facebook page https://www.facebook.com/munkdebates/ To sign up for a weekly email reminder for this podcast, send an email to firstname.lastname@example.org. To support civil and substantive debate on the big questions of the day, consider becoming a Munk Member at https://munkdebates.com/membership Members receive access to our 10+ year library of great debates in HD video, a free Munk Debates book, newsletter and ticketing privileges at our live events. This podcast is a project of the Munk Debates, a Canadian charitable organization dedicated to fostering civil and substantive public dialogue - https://munkdebates.com/ The Munk Debates podcast is produced by Antica, Canada's largest private audio production company - https://www.anticaproductions.com/ Executive Producer: Stuart Coxe, CEO Antica Productions Senior Producer: Christina Campbell Editor: Kieran Lynch Producer: Nicole Edwards Associate Producer: Abhi Raheja
Gerry addresses MLB's recent enforcement of rules against pitchers using foreign substances - from how the umpires are being asked to enforce it, to the specifics of the rules, to how it may trickle down to levels below the Major Leagues.
In this long-awaited episode, Host Ren discusses the spiritual Truth of what happens when you use drugs, alcohol, plant medicine, narcotics, pharmaceuticals, and other substances. These all affect your consciousness! All judgement aside - spiritual seekers, aspirants, and awakeners MUST become aware of the negative effects of using these. Whether heroin, cocaine, marijuana, ayahuasca, booze, or psilocybin - using these substances affects your spiritual anatomy and carries karmic consequences. Bonus content is a clearing of the negative effects of substance use accumulated in this and past lifetimes at patreon.com/letsgetmeta
BenGreenfieldFitness.com/recapturerapture My guest on today's podcast, Jamie Wheal, first joined me on the podcast episode: "Recapture the Rapture: Biohacking Sex, Tantric Breathwork, Plant Medicines For Orgasmic Enhancement & Much More!", for which the title is pretty self-explanatory regarding the wildly stimulating topics we covered on that show. Today Jamie, a so-called "neuroanthropologist" is back, describing exciting elements from his new book Recapture the Rapture: Rethinking God, Sex, and Death in a World That's Lost Its Mind - a book in which he maps out a revolutionary new practice—Hedonic Engineering—that combines neuroscience and optimal psychology. It's an intensive program of breathing, movement, and sexuality that mends trauma, heightens inspiration and tightens connections—helping us wake up, grow up, and show up for a world that needs us all. This is a book about a big idea. And the idea is this: Slowly over the past few decades, and now suddenly, all at once, we're suffering from a collapse in Meaning. Fundamentalism and nihilism are filling that vacuum, with consequences that affect us all. In a world that needs us at our best, diseases of despair, tribalism, and disaster fatigue are leaving us at our worst. It's vital that we regain control of the stories we're telling because they are shaping the future we're creating. To do that, we have to remember our deepest inspiration, heal our pain and apathy, and connect to each other like never before. If we can do that, we've got a shot at solving the big problems we face. And if we can't? Well, the dustbin of history has swallowed civilizations older and fancier than ours. This book is divided into three parts. The first, Choose Your Own Apocalypse, takes a look at our current Meaning Crisis--where we are today, why it's so hard to make sense of the world, what might be coming next, and what to do about it. It also makes a case that many of our efforts to cope, whether anxiety and denial, or tribalism and identity politics, are likely making things worse. The middle section, The Alchemist Cookbook, applies the creative firm IDEO's design thinking to the Meaning Crisis. This is where the book gets hands on--taking a look at the strongest evolutionary drivers that can bring about inspiration, healing, and connection. From breathing, to movement, sexuality, music, and substances--these are the everyday tools to help us wake up, grow up, and show up. AKA--how to blow yourself sky high with household materials. The final third of the book, Ethical Cult Building, focuses on the tricky nature of putting these kinds of experiences into gear and into culture—because, anytime in the past when we've figured out combinations of peak states and deep healing, we've almost always ended up with problematic culty communities. Playing with fire has left a lot of people burned. This section lays out a roadmap for sparking a thousand fires around the world--each one unique and tailored to the needs and values of its participants. Think of it as an open-source toolkit for building ethical culture. In Recapture the Rapture, Jamie takes radical research out of the extremes and applying it to the mainstream to the broader social problem of healing, believing, and belonging. It's providing answers to the questions we face: how to replace blind faith with direct experience, how to move from broken to whole, and how to cure isolation with connection. Said even more plainly, it shows us how to revitalize our bodies, boost our creativity, rekindle our relationships, and answer once and for all the questions of why we are here and what do we do now? Jamie is also the author of Stealing Fire: How Silicon Valley, Navy SEALs, and Maverick Scientists Are Revolutionizing the Way We Live and Work and the founder of the Flow Genome Project, an international organization dedicated to the research and training of human performance. His work and ideas have been covered in The New York Times, Financial Times, Wired, Entrepreneur, Harvard Business Review, Forbes, Inc., and TED. He has spoken at Stanford University, MIT, the Harvard Club, Imperial College, Singularity University, the U.S. Naval War College and Special Operations Command, Sandhurst Royal Military Academy, the Bohemian Club, and the United Nations. He lives high in the Rocky Mountains in an off-grid cabin with his partner, Julie; two children, Lucas and Emma; and their golden retrievers, Aslan and Calliope. When not writing, he can be found mountain biking, kitesurfing, and backcountry skiing. During our discussion, you'll discover: -What the heck is a "neuroanthropologist?"...07:34 -What does it mean to "recapture the rapture?"...15:15 -A contrarian view of the end times...23:56 -Jamie's creative writing process...31:55 -How prostate massages bring one to a new level of consciousness...43:25 -The 5 big techniques for achieving a peak state of flow...48:35 -Why sex, drugs, rock and roll mark the beginning of civilization, not the end...1:00:44 -About circular breathing...1:05:00 -Meduna's Mixture...1:10:12 -How to use breath to "steer" your psyche...1:23:40 -How to work directly with Jamie...1:28:05 -And much more! Episode sponsors: -The Boundless Cookbook -Kion Aminos -JOOVV -Clearlight Saunas -Paleo Valley Beef Sticks BenGreenfieldFitness.com/recapturerapture
(0:00) The second hour opens up with the guys discussing the red hot Boston Red Sox. (12:47) More thoughts on the Red Sox and the MLB. (22:56) Looking at the Patriots situation with Stephon Gilmore. (34:43) MLB pitchers and the use of sticky substances. See omnystudio.com/listener for privacy information.
, Rest In Peace, Jim fossil, mud cut grant, get well soon Christian Eriksen, Simone Biles wins seventh US title, Claressa shields when MM a fighting debut, Ronaldo all-time score in European champion history, Djokovic wins the French Open, Steve Smiththe in the booth, Lamar Odom KO, Floyd Mayweather fight, College football considering 12 teen format, baseball foreign Substances consequences, NBA awards, NBA playoffs, fantasy football running back rankings, got to be more careful Kevin Durant bodyguard suspended, Brett read pleads not guilty, Bell versus Andy Reid, Terrence McKinney seven second knock out and knee injury, 18 year old Virginia Tech player gets catfish, he went crazy, a fan jumps from the second floor to elude security, KD triple double, scotty Pippen Bourbon --- This episode is sponsored by · Anchor: The easiest way to make a podcast. https://anchor.fm/app
Expert layman Matt Goodwin (@TheCorkedMatt) and fake baseball economist Alexander Chase (@chase_rate) discuss the changing dynamics of Major League Baseball in the year 2021 that make the league...dynamic. They talk about the good, the bad, and the Yankees, with a little shade thrown in for the All-Star Game jerseys. note: episodes are recorded on Mondays or Tuesdays prior to Friday releases. Apple | Spotify | Google | Stitcher | Amazon | TuneIn | Radio.com | Deezer Timestamps | Bell Ringer: The Mandela Effect (03:54); Numbers of the Week: 16,18 and Kyle Schwarber (08:24); Central Question: What is the impact of the changing landscape of MLB in 2021? (11:01); Some specific changes (12:00); Sticky Situation (12:24); First Pitcher Ejected (12:58); Kyle Schwarber Continued (19:45); Was Substance Use More Widespread? (24:27); Gerrit Cole, Substances, and Confidence? (29:40); Is the Adjustment Period Over? (37:08); Can We Use Stats to Make Accusations? (38:52); Jose Altuve and What Numbers Can Help Us Understand? (41:03); Who Should We Be Talking About? email@example.com (46:57); The Yankees and Aaron Boone (49:35); All-Star Balloting and Horrible Unis (1:04:42) Join PL+ and support the podcast, get an Ad-Free Website, and access to our Discord community! Get PL+ and join our Discord: https://pitcherlist.com/plus
American Ideals The Declaration of Independence clearly lists the promises Americans are entitled to: life, liberty, and the pursuit of happiness. If people want to use drugs to pursue that happiness, they have a right to do so under the Declaration of Independence. Thomas Jefferson himself argued that a government deciding what we are allowed to ingest would be like living under tyranny. Drug prohibition policy, which is based on lies about the negative effects of drug use, would be un-American to him. Legalization and Decriminalization Legalization is the foundation of a humane drug policy because it makes room for regulation. Regulation can generate tax revenue and allows for quality control, which in turn ensures users are not taking adulterated substances that may not be safe. Decriminalization of drugs means you will not go to jail for using or owning certain drugs. However, selling drugs is still a criminal offense. America needs both legalization and decriminalization. Average Users The average drug user in America is the average American across all income brackets. The vast majority of drug users are responsible adults who hold jobs, pay taxes, are good parents, and will never be addicted. They consume drugs in the way most people use tobacco or alcohol. Only between 10-30% of drug users—even of substances like heroin and alcohol—are addicted. The false narrative that drug users are criminals, addicts, or mentally deficient is harmful and perpetuates prohibition drug policies. FIND OUT MORE: Dr. Carl L. Hart is the Chair of the Department of Psychology at Columbia University and the Ziff Professor of Psychology in the Departments of Psychology and Psychiatry. Professor Hart has published numerous scientific and popular articles in the area of neuropsychopharmacology and is co-author of the textbook Drugs, Society and Human Behavior (with Charles Ksir). He has appeared on multiple podcasts, radio and television shows—including Real Time with Bill Maher—and has also appeared in several documentary films including the award-winning “The House I Live In.” His essays have been published in several popular publications including The New York Times, Scientific American, The Nation, Ebony, The Root, and O Globo (Brazil's leading newspaper). You can follow him on Twitter @drcarlhart.
Hour 4- Chaim Bloom joins the show for the front office report. Why did the MLB crackdown on foreign substances so hard? A look at how much the crackdown is changing the MLB. Brado gives his Chaim Bloom interview grades. See omnystudio.com/listener for privacy information.
Rob Manfred has skillfully enacted his sticky substances plan and it has gone off with aplomb according to the commissioner himself, but is that true? Rob, Jeff, and Van talk how it has gone so far and what we can do going forward, as well as some bullpen talk, Wander Franco's struggles, Nate Pearson's recent injury, and much more!
TSN MLB Analyst Steve Phillips joined the OverDrive guys earlier today ahead of the Jays 4-game set versus Baltimore. He touched on the strong year for Robbie Ray and how George Springer has looked through two games. As well Steve speaks on the sticky substance debate & what it was like dealing with the media as a General Manager.
(00:10) Felger and Mazz got into last night's Boston Red Sox loss to the Tampa Bay Rays and the performance of pitcher Garrett Richards. (10:02) Have the new rules and penalties gotten into Richards' head? (23:31) The guys continued to talk about MLB and its crackdown on doctoring the ball. See omnystudio.com/listener for privacy information.
Dr Daniel Amen and Director of Research Development at House of Freedom, Orlando Vargas, cover more steps in the new 12 step program and discuss how bad habits are contagious.
(00:10) Felger and Massarotti kicked off the show discussing MLB's crackdown on foreign substances. Are pitchers overreacting? (24:33) The guys also discussed the Boston Red Sox and last night's 9-5 win over the Tampa Bay Rays. Is the Red Sox play sustainable? (33:19) In breaking news, the Boston Celtics are finalizing a deal to hire Brooklyn Nets assistant Ime Udoka. See omnystudio.com/listener for privacy information.
After the insanity of umpire inspections and pants dropping in the MLB, Brad is prepared for a full body cavity search on the podcast. Yeah, not the visual we wanted either. But on today's Fade Five, Brad loads up on a couple of strikeout props with Shohei Ohtani and Jose Urquidy and looks to tonight's NBA game with player props on Brook Lopez and Giannis Antetokounmpo. In the NHL, Nate sticks to his guns with the Islanders and hopes home ice can help force a Game 7. Plus hit streak bonus time with Raimel Tapia and more.
In this week's episode, Casey Scott and Dr. Matt Woolley are joined by Terra Leben(Care Coordinator - Odyssey House) to talk about feeling like she never fit in with her peers growing up, why she wanted to take her life at 8-years-old, and how seeking treatment as a teenager would shape who she would be as a young adult. Then Terra opens up about relapsing while in a treatment program as a teenager, being abused by her boyfriend and her boyfriend's dad as a fifteen-year-old, and the daunting reality she found herself in when she got the news that she was pregnant. Terra also talks about how her substance fueled teenage years pushed her to the brink of suicide, what her rock bottom looked like as she began to grow into an adult, and how she's learned from her years of abuse to make a change for so many others who are out there struggling with addiction and substance abuse. See omnystudio.com/listener for privacy information.
(0:00) Mazz and McCarthy open The Baseball Show discussing pitchers and their complaining about substances on the ball being banned. (11:35) More on pitchers and banned substances. (21:02) Alex Cora on former Red Sox outfielder Andrew Benintendi. See omnystudio.com/listener for privacy information.
(0:00) The second hour of Felger and Mazz opens up with the guys discussing the Patriots QB situation heading into the 2021 season. (10:57) A quick look at the Patriots Wide Receivers, including Jakobi Meyers. (23:05) MLB pitchers and new rules preventing substances being put on the ball. See omnystudio.com/listener for privacy information.
(00:20) Tony Massarotti opened up the show discussing Boston Red Sox pitcher Garrett Richards comments about MLB's new rules and penalties for doctoring the baseball. (14:39) Mazz continued to break down Garrett Richards comments after last night's Red Sox win in Atlanta. See omnystudio.com/listener for privacy information.
(00:20) Tony Massarotti kicked off the show discussing Alex Cora's comments to his pitching staff about MLB's new penalties for doctoring the baseball. (12:48) Mazz also talked about last night's Boston Red Sox win over the Atlanta Braves. See omnystudio.com/listener for privacy information.
Andrew is joined by Geoff Blum and David Tuttle of the Bleacher Blums podcast to talk about pitchers use of sticky substances, what MLB should do to fix the problem, how the current state of baseball compares to the PED era, if making a managerial change mid-season can help the Yankees and much more. Check out the Bleacher Blums podcast here: https://podcasts.apple.com/us/podcast/bleacher-blums/id1442621474 If you enjoy the podcast, please leave us a rating and review! It is the #1 way you can help out the show. Get in touch: @YankeesPodcast @Andrew_Rotondi @ScottReinen @robby_danks Submit to the mailbag: bronxpinstripes.com/podcast Call the voicemail line: 646-480-0342 Intro/Outro music: One Way Ticket, by Anitek
Barstool Sports presents the Starting 9, featuring Jared Carrabis and Dallas Braden, the baseball podcast everyone wants but no one else will give you. This week's first podcast features an interview with the legendary Hall of Famer Rod Carew, who talks about his experience coming up, his new book, his approach to hitting, the modern game and much more (1:06:45). Dallas and Jared also break down the latest in the foreign substance crackdown/conversation; Jacob deGrom's unbelievable heights (12:30); the surging Milwaukee Brewers (1:39:44); and much more.
It's time to buy-low on Charlie Blackmon if you still can (1:54)! Is there anything to see with Ryan Yarbrough following his complete game? ... We have a sticky situation on our hands (7:32)! Should you be worried about Gerrit Cole after his spin rate was down Thursday? ... News and notes (14:50)! Mad Bum went to the IL Andrew Vaughn went to the COVID IL, and Fernando Tatis returned to the lineup. ... Scott recently wrote about some prospects (17:48)! Should you be stashing Jesus Sanchez and Jackson Kowar? ... Week 11 sleepers (23:02)! Which two-start pitchers should you be targeting? What about sleeper hitters? ... Is now the time to trade Yelich after he hit a home run Thursday (33:21)? ... Should you drop Yasmani Grandal and Patrick Corbin (37:37)? ... We have deeper waiver wire adds (45:09). ... We wrap up with bullpens, streamers, and your APR questions (51:46)! ... Email us at firstname.lastname@example.org. 'Fantasy Baseball Today' is available on Apple Podcasts, Spotify, Stitcher, Google Podcasts, Castbox and wherever else you listen to podcasts. Follow our FBT team on Twitter: @FBTPod, @CTowersCBS, @CBSScottWhite, @Roto_Frank, @AdamAizer Join our Facebook group at https://www.facebook.com/groups/fantasybaseballtoday Sign up for the FBT Newsletter at https://www.cbssports.com/newsletters/fantasy-baseball-today/ For more fantasy baseball coverage from CBS Sports, visit https://www.cbssports.com/fantasy/baseball/ To hear more from the CBS Sports Podcast Network, visit https://www.cbssports.com/podcasts/ Subscribe to our YouTube channel: youtube.com/FantasyBaseballToday You can listen to Fantasy Baseball Today on your smart speakers! Simply say "Alexa, play the latest episode of the Fantasy Baseball Today podcast" or "Hey Google, play the latest episode of the Fantasy Baseball Today podcast." Learn more about your ad choices. Visit megaphone.fm/adchoices
Barstool Sports presents the Starting 9, featuring Jared Carrabis and Dallas Braden, the baseball podcast everyone wants but no one else will give you. This week's second podcast features some chatter on Joe West breaking the games umpired record, the legal vs illegal vs enforcement conversation about substances pitchers use/put on their hats, the Astros-Dodgers series, notable injuries Corey Kluber, Luke Voit, Bryce Harper & Marcell Ozuna and much more.