Having a tough day? Life got you down? Does your body feel like it's suffering from a severe lack of goat's blood, steroids, and placenta? Oh, and also meth? Then we know just what the doctor should order, and which doctor should order it! Rob teaches Ray about the infamous Max "Dr. Feelgood" Jacobson, and his wide ranging celebrity clientele; his unsavory and unsanitary business practices; how his miracle vitamin shots played a key role in Cold War diplomacy; and the contemporary figures whose similarly flexible medical morals have earned them Mr. Jacobson's unofficial title. If you like what we are doing, please support us on Patreon. TEAM Ray Hebel Robert W. Schneider Mark Schroeder Billy Recce Daniel Schwartzberg Gabe Crawford Natalie DeSavia ARTICLES EPISODE CLIPS "Dr. Feelgood" by Motley Crue (2021- Remaster) ADDITIONAL MUSIC & SOUND EFFECTS "Happy Bee" and “Double Polka” • Kevin MacLeod (incompetech.com) • Licensed under Creative Commons: By Attribution 4.0 • http://creativecommons.org/licenses/by/4.0/ Additional Sound Effects from Final Cut Pro, iLife, and Logic Pro Learn more about your ad choices. Visit megaphone.fm/adchoices
“Everyone is entitled to a defense” contend large law firms when they represent notorious corporate clients, but many of these firms push the ethical envelope. That's the crux of the discussion Ralph has with David Enrich as outlined in his book, “Servants of the Damned: Giant Law Firms, Donald Trump, and the Corruption of Justice.” Plus, we welcome Dr. Michael Jacobson, founder, and former director of Science in the Public Interest to tell us how we need to raise taxes on Science in the Public Interest to reduce alcohol-related deaths and mayhem.David Enrich is the Business Investigations Editor at the New York Times, and the bestselling author of Dark Towers: Deutsche Bank, Donald Trump, and an Epic Trail of Destruction. His latest book is Servants of the Damned: Giant Law Firms, Donald Trump, and the Corruption of Justice.There's a lot of lip service that the leaders of the legal industry pay to being good corporate citizens and being public-spirited officers of the court. And you often scratch a little bit beneath the surface of these giant law firms, and you realize that is just not true.David Enrich, author of Servants of the Damned: Giant Law Firms, Donald Trump, and the Corruption of JusticeIt was very clear to me the vast power that these law firms were wielding, not only defending their clients in and out of court, but also shaping the public's perception of how these fights were transpiring— in large part through the media. It's more or less taboo— in the mainstream media in particular— to really pull back the curtain on the way that those law firms are operatingDavid Enrich, author of Servants of the Damned: Giant Law Firms, Donald Trump, and the Corruption of Justice[Jones Day] is not a monolith, and it's not a place that I regard as evil. But it's really a classic example of a place where even well-intentioned lawyers go, and—to make a living or to repay their debts or whatever—and they sometimes end up really pushing the envelope.David Enrich, author of Servants of the Damned: Giant Law Firms, Donald Trump, and the Corruption of JusticeWhen they say “we believe in the position of the clients we represent…” it really isn't true. They don't believe in all the positions of their clients. And when you nail them on that issue, they say “Well, we're required by the professional code of ethics of our profession to zealously represent these clients. It's not up to us to expose their Achilles heel— that's what the adversarial system is for.”Ralph NaderMichael Jacobson holds a PhD. in microbiology from MIT. He is well-known for his nutrition advocacy that helped eliminate artificial trans-fat from the food supply, expose the enormous calorie counts of movie theater popcorn and many restaurant foods and make Nutrition Facts mandatory on food packages. Dr. Jacobson is the author of Salt Wars: The Battle Over the Biggest Killer in the American Diet.There's no doubt that raising alcohol taxes would raise the price of alcoholic beverages, and consumption would decline. For any kind of imaginable tax increase, alcohol problems and deaths would not go to zero. But there would be a significant decline in proportion to the increase in tax rates.Dr. Michael Jacobson This is a public episode. If you would like to discuss this with other subscribers or get access to bonus episodes, visit ralphnader.substack.com
Join us in the convoluted and confusing tale of the disappearances of Sandra and John Jacobson. We don't quite make it to Full T-Rex, but we do have soo many questions. Let us know what you think! Find our all our dumbassary at: https://linktr.ee/m3truecrimepod Find the best B's at True Crime BnB: https://linktr.ee/truecrimebnb Sources: https://charleyproject.org/case/sandra-mary-jacobson https://charleyproject.org/case/john-henry-jacobson https://www.kfyrtv.com/ https://www.thedickinsonpress.com/news/4-year-old-n-d-case-still-open https://www.jamestownsun.com/news/kidder-county-death-still-unsolved Music: Listen on Spotify: https://go-stream.link/sp-nick-cleveland Track: Liar Artist: https://slip.stream/artists/nick-cleveland Music by Slip.stream: https://slip.stream/tracks/f64560d6-370f-49fa-bbac-4068205ef56b
Joan Jacobson is a Right to Life Volunteer. David Kallman is Senior Counsel Great Lakes Justice Center. Right to Life of Michigan: 84-year-old volunteer was shot while canvassing
September 26, 2022 ~ Seth Jacobson, Professor of Planetary Science at Michigan State University, talks with Guy Gordon about NASA set to collide a spacecraft into a small asteroid in space. [Photo: Craig Bailey/Florida Today/USA Today Network]
Does your therapist know anything about human sexuality? Chances are…probably not. In this episode of the Sex Therapy Podcast, Dr. Stephanie Buehler, author of ‘What Ever Mental Health Professional Needs To Know About Sex' joins us to discuss the lack of training most therapists get in human sexuality and the treatment of sexual issues. Plus, Dr. Jacobson gives a review of the Touch X from We-Vibe and answers a woman who says that her boyfriend always loses his erection during intercourse, you don't want to miss the doctors advice.Do you have sex or relationship questions? Email them to firstname.lastname@example.org, or if you're living in the United States, you can call 1-616-DrCaleb.
In this Oddcast we continue the dive on Yale's senior year only fraternity, the very secretive Order of Skull, and Bones. We pick up from part one, and discuss more symbolism, influential members, and possible ties. We also look at several other prominent fraternities, and discuss the net worth of their trusts, and their most notable members, and connections as well. Thank you for your continued support, and i look forward to bringing you more content very soon. See Also: The Oddcast-The Order of Death Pt. 1 Ep. 104 The Order of Death Pt.1 (podbean.com) Cheers, and Blessings The Odd Man Out Help Support The Show, & Get Early, & Extra Content Odd Man Out Patreon https://www.patreon.com/theoddmanout Memento Mori “Remember That You Have To Die” The society was known to its members as the Eulogian Club: eulogia is Greek for “a blessing” and is applied in ecclesiastical usage to the object blessed. Fleshing Out Skull and Bones P. 192 Bones meanings are held at the tomb which is a two-story building without windows and who's walls on the outside are covered with Ivy. That's where the term Ivy League came from. The tomb is located to the east of the New Haven Green about 100 yards from the federal courthouse the Yale University owns the majority of land in downtown New Haven almost all of the university buildings are interconnected by a series of underground tunnels so visiting Bonesman never need approach the tombs from the street. Room B, called 322, is the "sanctum sanctorum" of the temple. Its distinguishing feature is a facsimile of the Bones pin, handsomely inlaid in the black marble hearth, just below the mantel, and also inlaid in marble is the motto: "Rari Quippe Boni," in old English text. The motto is said to come from the passage by Juvenal: ["Good men forsooth are scarce: there are hardly as many as there are gates of Thebes or mouths of the rich Nile."--Juvenal, Sat., xiii. 26.] "The order was incorporated in 1856 under the name “Russell Trust Association.” By special act of the state legislature in 1943, its trustees are exempted from the normal requirement of filing corporate reports with the Connecticut Secretary of State. As of 1978, all business of the Russell Trust was handled by its lone trustee, Brown Brothers Harriman partner John B. Madden Jr. Madden started with Brown Brothers Harriman in 1946, under senior partner Prescott Bush, George Bush's father." A grandfather clock is presented to each Knight upon initiation and stays with him throughout his life as a memento of what is called "the Bones experience." Iserbyt- Secret Societies https://youtu.be/cFQD1bAsUlw David Allen Richards Skulls, & Keys-The history of Yale secret societies https://youtu.be/4J4mRqND9aI Ron Rosenbaum-S, & B Peice https://youtu.be/apzwObT0qNM Alexandria Robbins/Secrets Of The Tomb Lecture https://youtu.be/KOKGt9Bl2wM Founded in the fall of 1996 by Rabbi Shmully Hecht, Ben Karp, "Cory Booker" and Michael Alexander as an intellectual salon and Jewish leadership society, the group that started out as a social club for would-be and current leaders of the Yale community has blossomed into an organization recognized the world over, yet with a decidedly secular twist. "There was no question that Eliezer was a Jewish association," says New York Times critic at large Edward Rothstein, a member of the society, "but also no question that along with its elements of religious observance and allusion, the aura was nonsectarian intellectual." http://content.time.com/time/nation/article/0,8599,2057526,00.html Eliezer now called Shabtai Shabtai has deep connections to Israeli political, military, and judicial figures and hosts regular off-the-record meetings and briefings on Israeli developments. Participants, many of whom have also been speakers and guests at Shabtai, include Aharon Barak, Elyakim Rubinstein, Hanan Melcer, Ehud Barak, Yuval Steinitz, Alex Lubotzky, Yoav Gallant, Daniel Taub, Ron Prosor, Danny Dayan, Ido Aharoni, Gideon Meir, and Yaakov Amidror, as well as other individuals like Gilad Shalit. International Jewish leaders meet regularly with Shabtai members to inspire their participation and receive their guidance on critical issues facing global Jewry. These have included Adin Steinsaltz, Ephraim Mirvis, Yanki Tauber, Tzvi Freeman, Emanuel Rackman, Sholom Dovber Lipskar, David Lincoln, James Ponet, Jacob Immanuel Schochet, Yitzchok Kogan, Y.Y. Jacobson, and Faivish Vogel, as well as many others. Videos https://vimeo.com/shabtai https://en.m.wikipedia.org/wiki/Shabtai_(society) Corey Booker Shabtai Founder https://yaledailynews.com/blog/2019/02/06/shabtai-founder-cory-booker-law-97-to-run-for-president/ See The Books: America's Secret Establishment: An... book by Antony C. Sutton (thriftbooks.com) Fleshing Out Skull & Bones:... book (thriftbooks.com) Skulls and Keys: The Hidden History of... book by David Alan Richards (thriftbooks.com) Alexandra Robbins Books | List of books by author Alexandra Robbins (thriftbooks.com) Odd Man Out Patreon https://www.patreon.com/theoddmanout ACR- My Podcasting Family Visit the home of The Oddcast at "Alternate Current Radio, and check out all their other great shows including, Boiler Room, and be sure to subscribe to their Social Media to get updates on all the fantastic talk, and music shows. https://alternatecurrentradio.com/ Check out the ACR video: "Shilling For Sanity" https://youtu.be/TyQv1JL78Eg Support the show by subscribing, liking, sharing, & donating! Fringe Radio Network- Radio on the Fringe! http://fringeradionetwork.com/ Patreon-Welcome to The Society Of Cryptic Savants https://www.bitchute.com/video/C4PQuq0udPvJ Social Media: _theoddmanout on Twitter, and Instagram Facebook https://www.facebook.com/theoddcastfttheoddmanout "A special Thank You to my Patrons who contributed to this episode. You are very much appreciated." Their Order Is Not Our Order!
Our world is going through a period of massive change. If we are to navigate our way through the myriad of challenges we must come together to find effective and lasting solutions. Brenda Jacobson & I explore the importance of collaboration if the business world is to thrive after all of the disruption it has experienced over the past few years. We consider the requirement for a new wave of influencers to step up & lead the creation of a brand new world in order to find solutions.
Have you had a paranormal experience on the job? We want to hear about it! Email us your story by midnight this Saturday 9/17. If we choose your story, you will be invited to be on the show to tell your story in your words! wltkdbParanormalRoom@gmail.com
This week Chris and Daniel recap episode 5 of She-Hulk: Attorney at Law. This episode is titled "Mean, Green, and Straight Poured into These Jeans". Summary: Titania has trademarked the name "She-Hulk" for a new line of beauty products, which angers Walters. Holliway warns Walters that she needs to deal with the situation quickly, and assigns Mallory Book as her attorney for the case. Ramos and Pug come up with a plan to acquire a superhero outfit for Walters from Luke Jacobson, a highly exclusive tailor who provides clandestine services for heroes, while Book and Walters counter-sue Titania, claiming that she is illegally exploiting She-Hulk's fame for profit. Walters is annoyed to discover that Todd, one of her unsuccessful dates, is also a client at her firm, but this helps her realize that she can use her dating app history to establish a past record of her identifying as She-Hulk before Titania tried to gain the trademark. With her past dates' testimonies, Walters wins the case and she establishes a tentative friendship with Book. Walters later acquires her new customized outfits from Jacobson. Visit us online: https://thereadercopypodcast.libsyn.com/ (Check out The Reader Copy Podcast website) Our iTunes page: https://goo.gl/MikhDd (Listen to more episodes) Even More Stuff: https://goo.gl/4iDTXn (Check out our Instagram) https://goo.gl/cVFw7r (Follow us on Twitter) https://goo.gl/RsnXc1 (Like us on Facebook) Show music provided by http://www.morgandavidking.com/ (MDK - Hyper Beam)
Luke Jacobson is the moment. On this episode we're going over: She-Hulk: attorney at law episode 5 Sequels and Production news And More This episode was: - Voiced By: Sam Harper - Written By: Sam Harper - Edited and Produced By: Sam Harper Twitter: @FourMins YouTube: https://youtube.com/c/Rapturepress RapturePress: http://www.rapture.press/ Liked the show? Hated the show? Got another 2 mins? Fill out a survey!:https://forms.gle/q6nGxA63m35NW8yR6 And follow us everywhere we are: https://linktr.ee/fourminsto --- This episode is sponsored by · Anchor: The easiest way to make a podcast. https://anchor.fm/app --- Send in a voice message: https://anchor.fm/4-mins-2/message
Anna Jacobson, Director of Exhibits & Education at the Arts Center, talks about her first year in the gallery and the newly installed Annual Art Show. She also reflected on her experiences and upcoming classes and events.
How far ahead to you plan your programs? We have new options this year from John Jacobson's JJ&Me site and from Musicplay! You'll get ideas for Nov. 11th, Holiday Concerts, and Spring Concerts. John Jacobson and Denise Gagne will share their musicals, revues, and great choral pieces for this upcoming season. To access the PD certificate and the handouts for this session please enroll in this webinar on Musicplay Workshops (FREE): https://workshops.musicplay.ca/courses/new-programs-for-concerts-webinar-with-john-jacobson-and-denise-gagne/
John Howell speaks with Dr. Sheldon H. Jacobson, Founder Professor in Computer Science at the University of Illinois. He joins the show to discuss his piece on how the electoral college system needs to be changed, but not just yet. Further, Dr. Jacobson says we need to repair our relationship between parties, and changing the constitution at this point would do the opposite of that. See omnystudio.com/listener for privacy information.
Episode 282 - A Conversation with Sex Therapist, Researcher, Biblical Jewish Scholar, Dr. Caleb Jacobson 0822 YouTube Video Link: https://youtu.be/dACg616URfk ABOUT: Dr. Caleb Jacobson is an internationally recognized clinical psychologist, sex therapist, researcher, Bible scholar, and host of the popular Sex Therapy Podcast. He has a doctorate in clinical psychology (PsyD) from California Southern University and a doctorate in Hebrew Bible and biblical archaeology (PhD) from the University of Mainz. Additionally he has a graduate certificate in sex therapy from the University of Wisconsin-Stout. As an expert on the topic of human sexuality, he authored Abrahamic Faiths: Perspectives on Gender Identity and Sexuality, a pioneering and innovative study on the correlation between gender identity, sexuality, and religion. He is the lead researcher of the 'Menstrubation Initiative,' a global study to quantify the benefits of masturbation on menstrual symptoms. Dr. Jacobson is the leading expert in Sex and Religion. He chairs the AASECT special interest group on the subject. Additionally, he is the president of the School of Sex Therapy, a professional training program for clinicians to become certified in the area of psychosexual therapy. GO TO: www.sextherapypodcast.com The official website of the Sex Therapy Podcast.
The author of ‘Losing It: Sex Education for the 21st Century,' and Vice reporter Sophia Smith Galer joins us to talk about problems and misinformation in modern sex education. The author and Dr. Caleb Jacobson even explore some of the common myths concerning sex and debunk them. Plus Dr. Jacobson gives a review of the WaterSlide from Lovability and responds to a woman who wants advice on telling her boyfriend she slept with his brother!Do you have sex or relationship questions you'd like answered on the show? You can send your questions to email@example.com or call 1-616-DRCALEB.
This week we review new series Shining Girls, Recipes for Love and Murder and Gutsy Women, the new season of The Handmaid's Tale, and the new movie, Thirteen Days. We also revisit the remake of A League of Their Own.
The king welcomes William A. Jacobson, the founder of Legal Insurrection, to discuss “special masters,” the FBI’s raid-not-raid of Trump’s Mar-a-Lago home, and the dark omens surrounding Biden’s Philadelphia speech. William Jacobson is a law professor and Director of the Securities Law Clinic at Cornell Law School. Professor Jacobson is frequently quoted in the media […]
What role does social media have in the advancement of sexual health? And what responsibility does it have for the decline in emotion intelligence? In this episode of the Sex Therapy Podcast, Dr. Caleb Jacobson discusses the negative impact of social media on the overall state of sexual health and it's impact on relationship satisfaction. Plus, Dr. Jacobson gives a review of the B-Vibe Trio Remote Control Plus and he responds to a woman who says uncertain how to talk to her wife about some sexual issues.Do you have sex or relationship issues? Would you like Dr. Jacobson to answer your questions on the show? Then email firstname.lastname@example.org or call 1-616-DRCALEB.
The king welcomes William A. Jacobson, the founder of Legal Insurrection, to discuss “special masters,” the FBI’s raid-not-raid of Trump’s Mar-a-Lago home, and the dark omens surrounding Biden’s Philadelphia speech. William Jacobson is a law professor and Director of the Securities Law Clinic at Cornell Law School. Professor Jacobson is frequently quoted in the media on political and legal topics... Source
(Lander, WY) – Mental Health Monday, the weekly segment on KOVE 1330 AM / 107.7 FM's Coffee Time, hosted by Vince Tropea, continued today with guest Matt Jacobson, the Community Relations Coordinator/Parent Liaison for Fremont County School District (FCSD) #1. Matt stopped by to discuss two mental health related events coming up for the district, one on September 15th, and the other on September 22. On the 15th, Laura Stack with the non-profit Johnny's Ambassadors (which Stack created after losing her son to suicide when he became addicted to high potency THC products), will speak on the dangers of modern youth marijuana use. On the 22nd, Dr. Lisa Strohman, a well known psychologist specializing in tech addiction, will give a presentation on social media and its negative impact on adolescents. Check out the full Mental Health Monday interview with Jacobson below to learn more about the events. The main goal of Mental Health Monday is to start an open dialogue about a number of mental health topics, and how folks are being affected on local, state and national levels. Guests range from psychiatrists, psychologists, school/drug/grief counselors, and any other professionals in the field, as well as testimonials from those affected by mental health issues, such as students, veterans, first responders, and many more. Be sure to check out Mental Health Monday on Coffee Time every Monday, and tune in to Coffee Time every morning at 8:00 AM on KOVE 1330 AM / 107.7 FM, or stream it live right here. If you would like to be a guest on Mental Health Monday, please reach out to email@example.com.
It's time for another edition of The Pathfinders, brought to you by Ansarada, with our host, former NFL Player, Investor, and Entrepreneur Dhani Jones. On this episode Dhani is joined by the President of The Drone Racing League (DRL), Rachel Jacobson. Rachel is a trailblazer in the world of professional sports league management and with Dhani she shares stories and insights from her 20 plus year career in the NBA and talks about what it's like to now run the first of its kind, professional high-speed Drone Racing League. You do not want to miss this episode of The Pathfinders, brought to you by Ansarada.You can also follow Rachel on LinkedIn and learn more about the exciting world of professional drone racing on the DRL's website or you can check them out on Youtube, Facebook, Twitter, Instagram, and TikTok. Don't forget to follow Dhani on Twitter, Instagram, and LinkedIn.Follow Us:LinkedIn @AnsaradaTwitter @ansaradaFacebook @AnsaradaPlatformInstagram @ansarada_Presented by Ansaradawww.ansarada.com
Britain Jacobson is a Project Management and Ops Strategist. In this episode of Specified Growth Podcast, Britain talks about the various roles he's played throughout his career and the importance of exploring different opportunities. He also discusses how he generates systems and creates SOP's efficiently, having a clear goal when starting up a business, communicating in an emotionally mature way, and more. Don't miss this episode of Specified Growth Podcast! Please reach out if you have any feedback or questions. Enjoy! Twitter: @TatsuyaNakagawa Instagram: @tats_talks LinkedIn: Tatsuya Nakagawa YouTube: Tats Talks www.tatstalk.com www.castagra.com Learn more about your ad choices. Visit megaphone.fm/adchoices
Today on Midwest Misfits we are talking with Scout Richters with the ACLU of NE For over 50 years, the ACLU of Nebraska has worked in courts, legislatures, and communities to protect the constitutional and individual rights of all people. With a nationwide network of offices and millions of members and supporters, the ACLU takes up the toughest civil liberties fights. Also joining the conversation is Andi Curry Grubb State Executive Director - of Planned Parenthood North Central States Advocates of Nebraska Planned Parenthood Advocates of Nebraska (PPAN) is an independent nonprofit, nonpartisan organization that works to educate and empower the electorate regarding issues of sexual and reproductive health and related rights of Nebraskans. Finally, it always helps to know how your senator voted last time. So we wanted to quickly let NE listeners know how their senators voted on a total trigger ban last session. OPPOSED EXTREME TOTAL BAN: Blood, Bostar, J. Cavanaugh, M. Cavanaugh, Day, DeBoer, M. Hansen, Hunt, McCollister, McKinney, Morfeld, Pansing Brooks, Vargas, Walz, Wishart PLEASE SEND THEM A THANK YOU NOTE! SUPPORTED EXTREME TOTAL BAN: Aguilar, Albrecht, Arch, Bostelman, Brandt, Brewer, Briese, Clements, Dorn, Erdman, Flood, Friesen, Geist, Gragert, Halloran, B. Hansen, Hilgers, Hilkemann, Hughes, Jacobson, Kolterman, Lindstrom, Linehan, Lowe, McDonnell, Moser, Murman, Sanders, Slama, Stinner, Williams (Gov. Ricketts has since appointed Sen. Dover to replace Sen. Flood, serving out a term that ends January 2025.) >>>> EXCUSED NOT VOTING: Lathrop, Pahls, Wayne (Gov. Ricketts has since appointed Sen. Kauthto replace the late Sen. Pahls until the November midterm elections.) --- Support this podcast: https://anchor.fm/midwest-misfits/support
Walter Jacobson wonders how the NASCAR race coming to Chicago for the next three years will play out for the city. How will the traffic be? Is it worth the hassle? Walter gives his perspective.
Mayoral candidate Willie Wilson has filed a lawsuit in Federal Court to stop the Chicago Board of Elections from reducing the number of precinct polling places. Walter gives his perspective.
Bronson and Steve are joined by a special guest and founding father of the MSU Deer Lab, Dr. Harry Jacobson. Travel back to the early Deer Lab days and learn of the pioneering research conducted, achievements gained throughout the years, and lessons learned along the way.
Bronson and Steve are joined by a special guest and founding father of the MSU Deer Lab, Dr. Harry Jacobson. Travel back to the early Deer Lab days and learn of early research conducted, achievements gained throughout the years, and lessons learned along the way. Enroll now in our free wildland fire course. Available to all! This podcast is supported by listener donations - thank you for being a part of this effort.
Data and analytics have rapidly become essential business tools. To make best use of these tools and techniques, organizations must find ways to democratize analytics – simplifying every aspect of data to make the process easy for everyone.We speak with Alan Jacobson, the chief data and analytics officer (CDAO) of Alteryx, to learn how organizations can democratize their data and analytics efforts.The conversation includes these topics:-- On Alteryx and the chief data and analytics officer role-- On organizational data strategy-- On the data mindset and adopting an analytics and data culture-- On making data and analytics easier to use-- On data and analytics in large organizations-- On metrics and KPIs for data analytics-- On operational metrics for evaluating data maturity and usage-- On data governance for analytics-- On data science and analytics training and employee upskilling-- On creating a culture of data and analytics awareness-- On democratizing data and analytics-- On Alteryx and making analytics easier for usersRead the complete transcript: https://www.cxotalk.com/episode/democratization-data-analytics-alteryxAlan Jacobson is the chief data and analytics officer (CDAO) of Alteryx, driving key data initiatives and accelerating digital business transformation for the Alteryx global customer base. As CDAO, Jacobson leads the company's data science practice as a best-in-class example of how a company can get maximum leverage out of its data and the insights it contains. He is responsible for data management and governance, product and internal data, and use of the Alteryx Platform to drive continued growth.Prior to joining Alteryx, Alan held a variety of leadership roles at Ford Motor Company across engineering, marketing, sales and new business development; most recently leading a team of data scientists to drive digital transformation across the enterprise.
Critical race theory has marched its way through many of America’s educational institutions. Angry elementary school parents noticed during the pandemic that their kids’ teachers were more inclined to teach them that white people were evil than to teach them to read. Unfortunately, critical race theory—which views everything through the lenses of race and oppression— […]
As well as dog cancer treatment information like a deep dive into medicinal mushrooms, this fall Dog Cancer Answers will also feature some True Tail stories about real-life dogs and their cancer journeys and more question and answer episodes from listeners like you. Links Mentioned in Today's Show: Dog Cancer Support Dog Cancer News Petco Love About Today's Guest, Molly Jacobson: Molly Jacobson is a writer. She is also the editor of the best-selling animal health book The Dog Cancer Survival Guide: Full Spectrum Treatments to Optimize Your Dog's Life Quality and Longevity. A lifelong dog lover and self-professed health nerd, she is all too familiar with dog cancer. She has been supporting readers of Dr. Dressler's website and book since the beginning. Molly earned a BA from Tufts University, and after a career in bookselling and book publishing attended The Swedish Institute to become a licensed massage therapist in New York State. LinkedIn Other Links: To join the private Facebook group for readers of Dr. Dressler's book “The Dog Cancer Survival Guide,” go to https://www.facebook.com/groups/dogcancersupport/ Dog Cancer Answers is a Maui Media production in association with Dog Podcast Network This episode is sponsored by the best-selling animal health book The Dog Cancer Survival Guide: Full Spectrum Treatments to Optimize Your Dog's Life Quality and Longevity by Dr. Demian Dressler and Dr. Susan Ettinger. Available everywhere fine books are sold. Have a guest you think would be great for our show? Contact our producers at DogCancerAnswers.com Have an inspiring True Tail about your own dog's cancer journey you think would help other dog lovers? Share your true tail with our producers. If you would like to ask a dog cancer related question for one of our expert veterinarians to answer on a future Q&A episode, call our Listener Line at 808-868-3200 www.dogcanceransers.com. Dog Cancer News is a free weekly newsletter that contains useful information designed to help your dog with cancer. To sign up, please visit: www.dogcancernews.com Learn more about your ad choices. Visit megaphone.fm/adchoices
Do you want to increase the size of your penis? Did you know that you can increase the size of your penis without a surgical procedure? Without pills, lotions, or dangerous weights. In this episode of the Sex Therapy Podcast, Dr. Sex Fairy herself, Dr. Kanwal Bawa joins us to discuss nonsurgical penis enlargement.Plus, Dr. Jacobson reviews the Autoblow AI+ and responds to a woman who is disappointed that the men she meets on dating apps become immediately sexual. If you have any sex or relationship questions, you can write to firstname.lastname@example.org or call 1-616-DRCALEB.
Subscribe to DTC Newsletter - https://dtcnews.link/signup Welcome to DTC Podcast. Today we're chatting with Rockerbox's Founder and CEO, Ron Jacobson. For the free DTC Benchmark report on which channels are growing fastest across hundreds of brands (and lots more) go to https://rockerbox.com/free) Rockerbox centralizes all of your marketing spend and campaigns (paid, organic, digital and offline). Get the free Rockerbox report ➝ https://rockerbox.com/free Subscribe to DTC Newsletter - https://dtcnews.link/signup Advertise on DTC - https://dtcnews.link/advertise Work with Pilothouse - https://dtcnews.link/pilothouse Follow us on Instagram & Twitter - @dtcnewsletter Watch this interview on YouTube - https://dtcnews.link/video
Sex therapy and religion don't often go together—but our guest on today's podcast, Dr. Caleb Jacobson, is an expert on both, and how they reinforce each other. Dr. Jacobson's website is https://sextherapypodcast.com. Here's the discount link to our sponsored product today. Dr. Chalmer's book Reigniting the Spark: Why Stable Relationships Lose Intimacy, and How to Get It Back is available wherever you get your books, or go to Dr. Chalmer's website. brucechalmer.com. Like this podcast? Review us, like us, follow us, and do all those other kinds of wonderful things to us! It helps people find the show. Visit us at ctin7.com! Music: Besamim (Spices) by Bruce Chalmer, performed by Fyre and Lightning Consort
Betty Dodson built a whole career helping women to appreciate their vaginas. For many women, they don't like the way their vaginas look - the color, the shape, their labia, etc. This has created huge demand within the cosmetic medical community for vaginal rejuvenation procedures. In this episode of the Sex Therapy Podcast, the CEO and founder of Lumisque, Lana Kerr discusses the benefits of carboxytherapy and the CO2Lift Vaginal Rejuvenation Treatment, a nonsurgical option for those who want to rejuvenate their vaginas!Plus, Dr. Jacobson gives a review of the Odile Butt Plug Dilator and answers a woman concerned that her partner's childhood abuse may effect their relationship. Don't miss this exciting episode of the Sex Therapy Podcast.Do you have sex or relationship questions? Email them to email@example.com, or if you're living in the United States, you can call 1-616-DrCaleb.
This month on Episode 39 of Discover CircRes, host Cynthia St. Hilaire highlights four original research articles featured in the August 5th and 19th issues of the journal. This episode also features an interview with Dr Annet Kirabo and Dr Ashley Pitzer from Vanderbilt University on their article, Dendritic Cell ENaC-Dependent Inflammasome Activation Contributes to Salt-Sensitive Hypertension. Article highlights: Jain, et al. Role of UPR in Platelets Orlich et al: SRF Function in Mural Cells of the CNS Xue et al: Gut Microbial IPA Inhibits Atherosclerosis Wang et al: Endothelial ETS1 on Heart Development Cindy St. Hilaire: Hi, welcome to Discover CircRes, the podcast of the American Heart Association's journal Circulation Research. I'm your host, Dr Cindy St. Hilaire from the Vascular Medicine Institute at the University of Pittsburgh, and today I'm going to be highlighting articles from our August 5th and August 19th issues of Circulation Research. I'm also going to have a chat with Dr Annet Kirabo and Dr Ashley Pitzer from Vanderbilt University about their study, Dendritic Cell ENaC-Dependent Inflammasome Activation Contributes to Salt-Sensitive Hypertension. But before I get to the interview, I first want to share an article from our August 5th issue, and that article is titled, Unfolded Protein Response Differentially Modulates the Platelet Phenotype. The first author of this study is Kanika Jain and the corresponding author is John Hwa from Yale University. Self-stress can lead to protein misfolding, and the accumulation of misfolded proteins can lead to a reduction in protein translation and may alter gene transcription, a process collectively known as the unfolded protein response, or UPR. UPR is well documented in nucleated cells; however, it has not been studied in platelets, which are anuclear, but do have a rapid response to cellular stress. In this study, they investigated the UPR in anucleate platelets and explore its role, if any, in platelet physiology and function. They found that treating human and mouse platelets with various stressors caused aggregations of misfolded proteins and induction of UPR-specific factors. Oxidative stress, for example, induced the UPR kinase PERK, while an endoplasmic reticulum stressor induced the transcription of the UPR factor XBP1. The team went on to study the UPR in platelets from people with type II diabetes, which is a population in which platelet mediated thrombosis is a major complication. They showed that protein aggregation and upregulation of the XBP1 pathway in diabetic patient platelets correlated with disease severity. Furthermore, treating the diabetic patient platelets with a chemical chaperone that helps to correct protein misfolding reduced protein aggregations and prevented the cells prothrombotic activation. This work confirms that even without transcription, platelets display stress-induced UPR, and that targeting this response may be a way to reduce thrombotic risk in diabetic patients. Cindy St. Hilaire: The second article I want to share with you is from our August 5th issue and is titled, Mural Cell SRF Controls Pericyte Migration, Vessel Patterning and Blood Flow, and it was led by Michael Orlich from Uppsala University in Sweden. Blood vessels are lined with endothelial cells and surrounded by mural cells. Vascular smooth muscle cells are the mural cells in the case of veins and arteries, and pericytes are the mural cells in the case of capillaries. In the capillaries, pericytes maintain blood-brain and blood-retina barrier function and can mediate vascular tone, similar to smooth muscle cells. While these pericytes and smooth muscle cells are related, they have distinct roles and characteristics. To learn more about the similarities and the differences between pericytes and smooth muscle cells, this group examined how each would be affected by the absence of SRF in the other. SRF is a transcription factor, essential for nonvascular or visceral smooth muscle cell function. In visceral smooth muscle cells, SRF drives expression of smooth muscle actin and other smooth muscle genes. Using mice engineered to lack SRF in mural cells, they show that SRF drives smooth muscle gene expression in these pericytes and smooth muscle cells, and its loss from smooth muscle cells causes atrial venous malformations and diminishes vascular tone. In pericytes, loss of SRF impaired cell migration in angiogenic sprouting. In a mouse model of retinopathy, activation of SRF drove pathological growth of pericytes. This work not only highlights the various functions of SRF in mural cell biology, but it also suggests that it has a role in pathological capillary patterning. Cindy St. Hilaire: The third article I want to share is from our August 19th issue of Circulation Research and is titled, Gut Microbially Produced Indole-3-Propionic Acid Inhibits Atherosclerosis by Promoting Reverse Cholesterol Transport and its Deficiency Is Causally Related to Atherosclerotic Cardiovascular Disease. The first authors are Hongliang Xue and Xu Chen, and the corresponding author is Wenhua Ling from Sun Yat-Sen University in Guangzhou, China. Recent studies provide evidence that disorders in the gut microbiota and gut microbiome derived metabolites affect the development of atherosclerosis. However, which and how specific gut microbial metabolites contribute to the progression of atherosclerosis and the clinical relevance of these alterations remain unclear. Gut microbiome derived metabolites, such as short-chain fatty acids and trimethylamine N-oxide, or TMAO, have been found to correlate with atherosclerotic disease severity. This study has now found that serum levels of indole-3-propionic acid, or IPA, are lower in atherosclerosis patients than controls. The team performed unbiased metagenomic and metabolomic analyses on fecal and serum samples from 30 coronary artery disease patients and found that, compared with controls, patients with atherosclerosis had lower gut bacterial diversity, depletion of species that commonly produce IPA and lower levels of IPA in their blood. Examination of a second larger cohort of atherosclerosis patients confirmed this IPA disease correlation. The team also showed serum IPA was reduced in a mouse model of atherosclerosis, and that supplementing such mice with dietary IPA could slow disease progression. Analysis of the macrophages from these mice showed that IPA increased cholesterol efflux, and the team went on to elucidate the molecular steps involved. The results of this study not only unraveled the details of IPA's influence on atherosclerosis, but suggest boosting levels of this metabolite could slow atherosclerotic disease progression. Cindy St. Hilaire: The last article I want to share is also from our August 19th issue, and it's titled, Endothelial Loss of ETS1 Impairs Coronary Vascular Development and Leads to Ventricular Non-Compaction. The first author is Lu Wang and the corresponding author is Paul Grossfeld, and they are at UCSD. Congenital heart defects, or CHDs, are present in nearly 1% of the human population. In some cases, the heart defects result from a genetic error, which can give researchers clues to its etiology. Jacobson syndrome is a complex condition caused by deletions from one end of chromosome 11, and the occurrence of a congenital heart defect in this syndrome has been associated with the loss of the gene ETS1. ETS1 is an angiogenesis promoting transcription factor, but how ETS1 functions in heart development was not known. Wang and colleagues now show that both global or endothelial-specific loss of ETS1 in mice caused differences in embryonic heart development that ultimately led to a muscular wall defect known as ventricular non-compaction. The mice also had defective coronary vasculogenesis associated with decreased abundance of endothelial cells in the ventricular myocardium. RNA sequencing of ventricular tissue revealed that, compared with controls, mice lacking ETS1 had reduced expression of several important angiogenesis genes and upregulation of extracellular matrix factors, which together contributed to the muscular and vascular defects. Cindy St. Hilaire: Today I have with me, Dr Annet Kirabo and Dr Ashley Pitzer, both from Vanderbilt University, and we're going to talk about their paper, Dendritic Cell ENaC-Dependent Inflammasome Activation Contributes to Salt-Sensitive Hypertension. This article is in our August 5th issue of Circulation Research. Thank you both so much for joining me today. Annet Kirabo: Yeah, thank you so much for having us. Ashley Pitzer: Yeah, thank you for having us. Cindy St. Hilaire: Yeah, it's a great paper. I think we're all familiar with hypertension and this idea that too much salt is bad for our cardiovascular system. When I was a kid, my grandparents had those salt replacements on their kitchen table, Mrs. Dash and whatever. But, like you said in the start of your paper, the exact mechanism by which salt intake increases blood pressure and also increases cardiovascular risk, it's not really well understood, and you guys are focusing on the contribution of immune responses in this process or in this pathogenesis. Before we dig into the details of your paper, I was wondering if you could give us a little bit of background about what's known regarding the role of inflammation in this salt-sensitive hypertension pathogenesis. Annet Kirabo: Yeah. It's difficult to know where begin to from, but the role of inflammation in cardiovascular disease have been known for many, many decades. Right now, Dr David Harrison showed more than 10 years ago that T cells contribute to hypertension, but the mechanisms were not known. Back when I was a post doc in David Harrison's lab, we discovered a new mechanism, how immune cells are activated in inflammation and hypertension, whereby we found that there is increased oxidative stress in antigen-presenting cells. This leads to formation of oxidative products known as arachidonic acid or lipid products known as isolevuglandin, or IsoLGs. These IsoLGs are highly, highly reactive and they adapt to lysines on proteins. This is a covalent binding, which leads to permanent alteration of proteins, and so these proteins act as neoantigens that are presented as self-antigens to T cells, leading to an autoimmune-like state in hypertension. Annet Kirabo: We found that these antigen-presenting cells are activated and they start producing a lot of cytokines that paralyze T cells to IL-17 producing T cells that contribute to hypertension. And so, when I started my lab back in 2016, we discovered that excess dietary salt profoundly activates this pathway, and we found for the first time that these antigen-presenting cells, they express ENaC, the epithelial sodium channel, and sodium goes into these antigen-presenting cells and activates the NADPH oxidase, which is an enzyme which produces this reactive oxygen species, leading to this IsoLG formation, which I've talked about, and leading to inflammation. So, three years ago when Ashley joined my lab, she had extensively studied the inflammasome in her PhD program, and she suggested why don't we look at the role of the inflammasome in this pathway and how IsoLG may contribute to this. In her paper that we are discussing right now, she found that in a dependent manner, sodium enters the cell and activates this pathway, and the NLRP3 inflammasome is involved in this process. Cindy St. Hilaire: That's such a wonderful story that fits together so many pieces. One of the things you talk about, which I guess I didn't even appreciate myself is, there are certain individuals out there who are more salt-sensitive than others. Annet Kirabo: Yeah. Cindy St. Hilaire: What is that difference? Do we know the root cause of that? And then also, how many individuals are we talking about are salt-sensitive? Annet Kirabo: Salt-sensitive blood pressure, it is a variable trait and it's normally distributed in the population, but it happens more in some individuals than others. It happens even in 25% of people without any hypertension. These people go to that doctor, that doctor thinks they're normal, they don't have any hypertension, but these people can be at a risk of sudden heart attack or cardiovascular risk or even a stroke, simply because when they eat a salty meal, their blood pressure will go up. Cindy St. Hilaire: Yeah, that's one of my questions. How much salt are we talking about here? And not only how much in a meal, but a sustained amount? How bad is a miso soup a day? Annet Kirabo: Yes. The American Heart Association and the World Health Organization have recommendations. American Heart Association recommends one spoon per day. We have refused to adapt to this recommendation, but that is the recommendation that they have recommended per day to eat. But this is difficult because most of the salt, as you know, is already in our food through processing in our processed foods and we don't have any control over how much salt we have, and there's also a lot of adding of salt at a table. Cindy St. Hilaire: Ashley, your background was more the inflammasome. What were your thoughts entering into this project? Did you have much of a hypertension background? Ashley Pitzer: No. My graduate thesis focused mainly on endothelial dysfunction and cardiovascular disease, and so it was a pretty easy segue. But it was just with Annet, so excited about the project and showing me all the data and this robust IL-1 beta production that she was seeing after these immune cells being exposed to high salt, I, with my inflammasome background, was immediately like, this could be playing a role. And so it was, like I said, a pretty easy transition and, as is in the paper, we're doing human studies. All of my research back in grad school was very basic research, so it was very exciting to see how our research was being translated with people having this condition and potentially finding mechanisms where we can target this to help actual people. Cindy St. Hilaire: I think a lot of us who are not in the hypertension field, and maybe this was you before you joined Annet's lab, we really only kind of think of the kidneys and the blood vessels when we think about hypertension, but studies like this are changing that. And I think a lot of Annet's earlier work, as well as the work of others, have shown a role for this epithelial sodium channel as an important player in this salt-induced hypertension. New to me, it's not just found in the kidney, which I totally did not appreciate that. And it's this channel sensing the salt that can trigger this IL-1 beta production that does a whole bunch of other things. Cindy St. Hilaire: What are those other things? What are those cells that are affected and where is this happening? Obviously it's not just kidney cells, but is it only in the kidney or are these systemic cells? What do we think is happening? Ashley Pitzer: That's the question, is, where is this happening? There's been studies at Vanderbilt by Jens Titze and his lab showing, where are these immune cells sensing the salt? And so they've shown that sodium accumulates in the skin, a huge argument is for they're sensing the sodium in the kidney because that's where a lot of it is being processed. But these immune cells travel through the whole body, so they're seeing it where there are the highest amounts of sodium concentration, and so I would argue it's in the kidney. Annet Kirabo: Indeed, because we're now collaborating with Tina Kon, and we have recently published with her a paper in the International Journal of Science, where we have done sodium MRI and we find this accumulation of sodium in the kidney even much more than in the skin. And we know that the kidney is where sodium is highly concentrated. So the working hypothesis in the lab is that these immune cells can be activated wherever they are, in the lymph nodes or not, in other tissues, but they can travel to the kidney. We find that in high salt, if you feed high salt to the mouse, the endothelium in the kidney becomes dysfunctional and it expresses molecules, chemoattractants, that attract these immune cells in the kidney. We think that the high salt accumulation in the kidney can activate these, and then these immune cells are activated and they produce cytokines. Dr Steve Crowley showed that they can produce IL-1 beta, which induces activation of sodium channels that can be induced. We have also actually found that even IL-17 can be produced by these immune cells in the kidney and they can activate sodium channels in the kidney, leading retention of sodium and water and hypertension. Cindy St. Hilaire: Very cool. You used a lot of mice in this paper. Can you tell us, I just want to know a little bit about the models you chose to use, but also how similar is hypertension in mouse and humans? Obviously for atherosclerosis, we have to do lots of things to get them to form a plaque. Is hypertension similar in a mouse and do mice also show this salt-sensitive phenotype? Annet Kirabo: That is an extremely important point. If you read our paper, we use a slightly different approach. Most people do benchside to bed approach. We did the opposite. We did a bed to benchside approach. Cindy St. Hilaire: Always smart. Annet Kirabo: Yeah. We first started humans, and then with some references, we went to the mice, because I think when it comes to salt-sensitive blood pressure, mice are different from humans. In fact, if we look in the lab, we find that female mice are protected from salt-sensitive blood pressure, but we find that in the humans, it's the opposite. Females are more prone to salt-sensitive hypertension. Those are studies that we are doing right now. We haven't published. But we know that it can be different. The model we use most of the time in the lab, the C57 mice, are resistant to salt-sensitive hypertension. These C57 mice would rather die before they raise their blood pressure in response to salt. We can induce salt-sensitivity in these mice like in the paper that we are discussing. When we induce the endothelial dysfunction using L-NAME and we wash it out, then these mice, when you give them, subsequently, salt, suggests that they become salt-sensitive. But we also have a salt-sensitive mouse model that we use, the 129/SV mouse. So we use several models to kind of prove the same thing over and over again with the findings that we found in humans. Cindy St. Hilaire: And you used a technique, which I'm a little bit familiar with, but I'd like to hear, A, about it from you, but also your experience in using it, and that is CITE-seq. So, how does that work? Ashley Pitzer: That was with our human study where we actually had patients come in, who were hypertensive, took them off medication for 2 weeks. They come in, we get baseline samples, we give them a salt load on one day, and then the next day we completely salt deplete them. Cindy St. Hilaire: How much is a salt load? Like a Big Mac? What's a salt load? Ashley Pitzer: Yeah, it's pretty much just like eating Lays chips all day. It's a lot of salt. It's a very salty meal. Annet Kirabo: And then in addition, we also infuse saline too. Cindy St. Hilaire: Oh, wow. Annet Kirabo: Because these people, when they come into the hospital, some them have already eating high salt. This approach is to just maximize the whole system so that then when we sort deplete everybody, it's at the same level and it's just to unify the whole process. But sorry, Ashley, you go ahead. Ashley Pitzer: With the CITE-seq, we're able to take different patients on different days. So we take samples each day, and we can give each sample a barcode, basically. Give them a barcode, we can pool them all together, process them, and we can sequence their RNA, we can probe for a certain amount of protein expression as well. So then when we analyze, we can look at protein expression, so you get the translation and the transcription for each person on each day, and then you're able to compare. And so you get this huge picture and it's a lot of data. Cindy St. Hilaire: How long did it take you to sort through? Ashley Pitzer: Well, we have a statistician who does all of that, because my wheelhouse is here and it is on a different planet. So we have somebody who helps us with that who does an unbiased approach. And then once he does an analysis, gives us back what are the things that are changing the most, and one of those was IL-1 beta. Annet Kirabo: As you can see, our list is huge, this is a massive input of so many collaborators. We have computational people on there that help us with this. I can't even begin to learn these techniques, but with all this collaboration and the resources at Vanderbilt, these things are possible. And so, this is a really powerful approach where you can combine protein expression and you get the specific cells that express the genes and you couple the channel type to the gene expression. Annet Kirabo: We actually found that not all monocytes are the same. There's a specific class that of monocytes, A small class of monocytes that is so angry, and the inflammasome is activated and producing this IL-1 beta, and that is enough to contribute to this phenotype of salt-sensitive hypertension, which dynamically changed according to blood pressure, suggesting that this is a targetable salt-sensitive blood pressure, even in normotensive people, is a targetable trait. And because these monocytes are in blood, can we get a blood sample and routinely diagnose salt-sensitive blood pressure so that doctors are aware and they can appropriately advise patients. Cindy St. Hilaire: This was samples obviously taken from a blood draw, right? So they're circulating. Annet Kirabo: It was a blood draw, yes. Cindy St. Hilaire: What do you think about these immune cells, perhaps, native in the kidney? Do you think the small population of angry cells, like you said, is escaping from the kidney environment? What do you think? Annet Kirabo: When I was a post-doc in David Harrison's lab, we found that the most angry dendritic cells that contribute to this inflammation and hypertension are monocyte-derived. So that's why in the human study we focused on monocytes, because there are so many subtypes of dendritic cells, plasmacytoid dendritic, classical dendritic cells. We have studied all of these subtypes, and we have focused on monocyte-derived dendritic cells because they're the ones that seem to be contributing to this phenotype the most. Cindy St. Hilaire: You guys focused in on the NLRP3 inflammasome, which, obviously it's a really critical component broadly for the innate immune system. Do you think that this is going to be a targetable approach that can be leveraged for hypertension? Or do you think it's too broad? What do you think about that as a therapeutic potential? Ashley Pitzer: Even when you look in our paper, and we use a knockout model, where we use a completely global knockout model, put them on high salt, and we give them back only dendritic cells that are from wild-type mice, so they have that NLRP3, that have been exposed to high salt. We were able to increase blood pressure, but I also did, in mice, where I gave them an IL-1 beta neutralizing antibody, similar to canakinumab, which is the CANTOS trial, and there's not much of a difference. There is, but it's minor. It's very minor. Ashley Pitzer: So, to be able to target in specific cell types in humans one thing, it's very difficult, and maybe one day we can get there. But I think it at least gives us a better idea of what is the full picture, what's the big mechanism going on with immune cells? In part of our human study, we are looking at something to try and be able to identify who is salt sensitive. So if anything, we're able to sit here and potentially have a way of identifying salt-sensitive patients, where, right now, all we can do is have them come in like we do and do a 3-day study, and not everybody can do that. Annet Kirabo: To add onto that, perhaps you know, we are talking about precision medicine. This is an era of precision medicine where you need to really tailor treatments if we can get there, and I think this is one way. CANTOS trial. They had no way of knowing who is salt-sensitive and who is not, it was a global approach, and the lack of differences in blood pressure might be explained that this IL-1 beta pathway is targetable in a specific population whose blood pressure is probably driven by inflammation. There are so many, many mechanisms that drive hypertension, and so perhaps we need to focus this on salt-sensitive people, and maybe we can really use this approach to target. Plus, this is ENaC-dependent. As you know, amiloride has lost favor in the clinic as a treatment of hypertension, because in the majority, it's not effective. But studies have shown that in Black men, for example, who had been categorized salt-resistant, when they give them amiloride, their blood pressure went down, and yet it's not effective in the majority of the people. So, can we bring back, can we take another look at amiloride. As our studies indicate that blockade of ENaC is anti-inflammatory and it's also antioxidant agent, can we at least bring back amiloride and look at it again and we focus it for specific populations of people that may be more prone to salt-sensitive hypertension? Here we have so many targets for potential precision treatment of salt-sensitive potential in this paper. You can target SGK1, which we know is possible, we listed a number of clinical trials that they have used NLRP3 inflammasome inhibitors, you can use amiloride for these people, and you can also potentially scavenge IsoLGs. Cindy St. Hilaire: What was the most challenging aspect of this study? There's a lot of moving parts, so what was the biggest challenge? And then, also, what was the most surprising part or the most pleasantly surprising part? Ashley Pitzer: You have to think, most of this was going on right when the pandemic hit. And right before that, we had started our human recruitment for the human study. And so that put a little bit of a time damper on it. Ashley Pitzer: Other than that, it was just, we were finding one thing, developing a new experiment, doing it again, doing it again. And honestly, what was the most surprising and rewarding was just seeing the same thing in, because we took just PBMCs from normotensive patients, treated them with high salt, and saw the changes that we did with the inflammasome. And to see that exactly again in an in vivo model of giving patients high salt and seeing the same thing, it was very rewarding and confirmed that, okay, we're on the right path. Seeing the same thing over and over and over again, it kind of reaffirms that you had a good idea. Annet Kirabo: I might add, one of the most challenging was, initially, the computational. Oh, part of the pandemic I was, the pandemic hit, I had a baby during the pandemic, and it was my time to leave my home, and then all these things were going on. We had a clinical trial where patients had to come in. Vanderbilt was so super supportive ,even checking for COVID-19. Our patients could not have COVID-19. We needed to check them. Cindy St. Hilaire: Yeah. Annet Kirabo: They also had to check for COVID-19. And so during that time, I realized, wait, I need learn computation analysis. I realized I cannot learn, and then reached out to collaborators that helped. That was extremely challenging. And then the other challenging thing that we faced later during the pandemic is vaccinations. In our criteria, these people cannot be vaccinated for reasons. We've studied inflammation, hypertension, and so vaccination was confounding. And even COVID-19 is even more for confounding. So we had this exclusion criteria where we could not recruit anyone. Annet Kirabo: Everybody was having COVID, everybody was being vaccinated, and everybody was in that exclusion criteria, so it was difficult to get people. We have had some slow down, but right now it's beginning to build up. Cindy St. Hilaire: So, what's next? What's the next question? Annet Kirabo: We have so many. Cindy St. Hilaire: That means it was a great study. If you have more, that means it was a great study. Annet Kirabo: Yeah. This study and us, it kind of warms. The inside seat just opened up, we have primary data in the genetic regulation of ENaC, we have primary data where we found. We are trying to figure out the specific ENaC channel in these antigen-presenting cells. We don't know. We found that ENaC delta, for example, it's not found in a kidney or you talked about a kidney contribution versus immune cells. ENaC delta is not found in the kidney, but we have primary data that show that ENaC delta is the most correlated with cardiovascular risk, is the most correlated with kidney disease and all forms of hypertension. So now we're like, ENaC delta expressed in the immune cells, not in the kidney, it is the one that is most involved in cardiovascular disease, so how are we going to tell the world that. Cindy St. Hilaire: Yeah, very cool. Annet Kirabo: Those cells, not necessarily the kidney. The kidney plays a part because the cells are going there, but it's very, very exciting. Plus a number of other lines that we are investigating. Cindy St. Hilaire: It's great. Well, congratulations, again, on this publication, on just getting all this done with what sounds like extremely difficult patient recruitment. So, Dr Kirabo and Dr Pitzer, thank you so much for joining me today and I'm looking forward to these next studies on maybe ENaC delta. Annet Kirabo: Thank you. Thank you so much. Ashley Pitzer: Thank you for having us. Cindy St. Hilaire: That's it for the highlights from the August 5th and August 19th issues of Circulation Research. Thank you for listening. Please check out the CircRes Facebook page and follow us on Twitter and Instagram with the handle @CircRes and hashtag Discover CircRes. Thank you to our guests, Dr Annet Kirabo and Dr Ashley Pitzer. This podcast is produced by Ashara Ratnayaka, edited by Melissa Stoner, and supported by the editorial team of Circulation Research. Some of the copy text for the highlighted articles is provided by Ruth Williams. I'm your host, Dr Cindy St. Hilaire, and this is Discover CircRes, your on the go source for the most exciting discoveries in basic cardiovascular research. This program is copyright of the American Heart Association 2022. Opinions expressed by speakers in this podcast are their own, and not necessarily those of the editors or of the American Heart Association. For more information, visit ahajournals.org.
David Druid har beef med några tidningar. Kodjo Akolor, mer känd som Kodjo blir exalterad och fanatisk över visual effects-mästaren Niklas Jacobson som är TRIPPELT Emmy-nominerad och gästar oss! Det snackas även om hur man sålde random grejer som barn och stökiga hemmafester a la Project X. Hitmakaren och Idol-jurymedlemmen Alexander Kronlund gästar också oss! Det blir Idol-snack, kändissnack och allt däremellan! Programledare: David Druid och Kodjo Akolor.
Listen in to get a sneak peek at some of our upcoming episodes (hint: next week's interview is a game-changer for dog cancer screening!) plus to hear about some of the resources available online. Links Mentioned in Today's Show: Dog Cancer Support Dog Cancer News About Today's Guest, Molly Jacobson: Molly Jacobson is a writer. She is also the editor of the best-selling animal health book The Dog Cancer Survival Guide: Full Spectrum Treatments to Optimize Your Dog's Life Quality and Longevity. A lifelong dog lover and self-professed health nerd, she is all too familiar with dog cancer. She has been supporting readers of Dr. Dressler's website and book since the beginning. Molly earned a BA from Tufts University, and after a career in bookselling and book publishing attended The Swedish Institute to become a licensed massage therapist in New York State. LinkedIn Other Links: To join the private Facebook group for readers of Dr. Dressler's book “The Dog Cancer Survival Guide,” go to https://www.facebook.com/groups/dogcancersupport/ Dog Cancer Answers is a Maui Media production in association with Dog Podcast Network This episode is sponsored by the best-selling animal health book The Dog Cancer Survival Guide: Full Spectrum Treatments to Optimize Your Dog's Life Quality and Longevity by Dr. Demian Dressler and Dr. Susan Ettinger. Available everywhere fine books are sold. Have a guest you think would be great for our show? Contact our producers at DogCancerAnswers.com Have an inspiring True Tail about your own dog's cancer journey you think would help other dog lovers? Share your true tail with our producers. If you would like to ask a dog cancer related question for one of our expert veterinarians to answer on a future Q&A episode, call our Listener Line at 808-868-3200 www.dogcanceransers.com. Dog Cancer News is a free weekly newsletter that contains useful information designed to help your dog with cancer. To sign up, please visit: www.dogcancernews.com Learn more about your ad choices. Visit megaphone.fm/adchoices
Throughout the US laws and policies are changing quickly, what effect do they have on your sex life? Well, in this episode of the Sex Therapy Podcast, Dr. Joshua Estrin joins us to talk about it. Plus, Dr. Jacobson does a review of the Charmer silicone dildo from Tantus, Inc. And he gives advice to a man who says that his girlfriend makes him feel undesired until he pulls away from the relationships. Do you have a sex or relationship question? You can email them to firstname.lastname@example.org or call 1-616-DRCALEB.
Jeremy Jacobson of Go Curry Cracker talks about inflation pontification Episode 1993: Inflation Pontification by Jeremy Jacobson Winnie Tseng is from Taiwan and is the Go Curry Cracker resident photographer. After working in high tech, she found her real love making magic happen behind the camera and in the kitchen. Now she travels the world in search of new flavors and images. Jeremy Jacobson is from the United States and is the Go Curry Cracker blog writer. His love of learning and adventure make permanent travel the ideal lifestyle. The original post is located here: https://www.gocurrycracker.com/inflation-pontification/#more-15148 Visit Me Online at OLDPodcast.com Interested in advertising on the show? https://www.advertisecast.com/OptimalFinanceDaily Learn more about your ad choices. Visit megaphone.fm/adchoices
Dave Jacobson is the Senior Marketing Manager for Visit Aurora, and was a staple in the Colorado radio scene for a decade plus. His upbringing gave him a unique perspective on life, and the ups and downs throughout it have made him into the strong person he is today. After a tumultuous ending to his career at iHeart, Dave found himself again, and what makes him truly happy. Going from rubbing shoulders with the likes of Dave Chappelle and Taylor Swift to interviewing local business owners in Aurora, one thing Dave always does is make the most of what life brings him. To learn more about Dave and his dog Toby, give him a follow on Instagram @davejonthemic.
Dr. Feelgood: The Shocking Story of the Doctor Who May Have Changed History by Treating and Drugging JFK, Marilyn, Elvis, and Other Prominent Figures Doctor Max Jacobson, whom the Secret Service under President John F. Kennedy code-named “Dr. Feelgood,” developed a unique “energy formula” that altered the paths of some of the twentieth century's most iconic figures, including President and Jackie Kennedy, Marilyn Monroe, Frank Sinatra, and Elvis. JFK received his first injection (a special mix of “vitamins and hormones,” according to Jacobson) just before his first debate with Vice President Richard Nixon. The shot into JFK's throat not only cured his laryngitis, but also diminished the pain in his back, allowed him to stand up straighter, and invigorated the tired candidate. Kennedy demolished Nixon in that first debate and turned a tide of skepticism about Kennedy into an audience that appreciated his energy and crispness. What JFK didn't know then was that the injections were actually powerful doses of a combination of highly addictive liquid methamphetamine and steroids. Author and researcher Rick Lertzman and New York Times bestselling author Bill Birnes reveal heretofore unpublished material about the mysterious Dr. Feelgood. Through well-researched prose and interviews with celebrities including George Clooney, Jerry Lewis, Yogi Berra, and Sid Caesar, the authors reveal Jacobson's vast influence on events such as the assassination of JFK, the Cuban Missile Crisis, the Kennedy-Khrushchev Vienna Summit, the murder of Marilyn Monroe, the filming of the C. B. DeMille classic The Ten Commandments, and the work of many of the great artists of that era. Jacobson destroyed the lives of several famous patients in the entertainment industry and accidentally killed his own wife, Nina, with an overdose of his formula. Skyhorse Publishing, along with our Arcade, Good Books, Sports Publishing, and Yucca imprints, is proud to publish a broad range of biographies, autobiographies, and memoirs. Our list includes biographies on well-known historical figures like Benjamin Franklin, Nelson Mandela, and Alexander Graham Bell, as well as villains from history, such as Heinrich Himmler, John Wayne Gacy, and O. J. Simpson. We have also published survivor stories of World War II, memoirs about overcoming adversity, first-hand tales of adventure, and much more. While not every title we publish becomes a New York Times bestseller or a national bestseller, we are committed to books on subjects that are sometimes overlooked and to authors whose work might not otherwise find a home.
THE THESIS: FACT: The Party's CDC has been caught colluding with social media companies to censor free speech. THEORY: This expressly illegal act is not an outlier, The Party is a unit--federal bureaucracies, media, academia, tech, pharma and finance--and the government is at constant work with media companies to control the narrative. As proof, I offer the refusal to report on Hunter Biden, the chemical and surgical mutilation of children, the forcing of culture war ideology into government and medicine, the damage and deaths caused by the mRNA. THE SCRIPTURE & SCRIPTURAL RESOURCES: God allows free speech. In fact, through The Lord, Jesus, he engaged in it, even debating people! Colossians 1:15-23 The Supremacy of the Son 1 On many past occasions and in many different ways, God spoke to our fathers through the prophets. 2But in these last days He has spoken to us by His Son,a whom He appointed heir of all things, and through whom He made the universe.b 3 The Son is the radiance of God's glory and the exact representation of His nature, upholding all things by His powerful word. After He had provided purification for sins, He sat down at the right hand of the Majesty on high. 4 So He became as far superior to the angels as the name He has inherited is excellent beyond theirs. 5 For to which of the angels did God ever say: “You are My Son; today I have become Your Father”? Or again: “I will be His Father, and He will be My Son”? 6 And again, when God brings His firstborn into the world, He says: “Let all God's angels worship Him. 7 Now about the angels He says: “He makes His angels winds, His servants flames of fire.” But about the Son He says: “Your throne, O God, endures forever and ever, and justice is the scepter of Your kingdom. 9 You have loved righteousness and hated wickedness; therefore God, Your God, has anointed You above Your companions with the oil of joy.” 10 And: “In the beginning, O Lord, You laid the foundations of the earth, and the heavens are the work of Your hands. 11 They will perish, but You remain; they will all wear out like a garment. 12 You will roll them up like a robe; like a garment they will be changed; but You remain the same, and Your years will never end.” 13 Yet to which of the angels did God ever say: “Sit at My right hand until I make Your enemies a footstool for Your feet”? 14 Are not the angels ministering spirits sent to serve those who will inherit salvation? THE NEWS & COMMENT: Support: Dismantling The Woke Infrastructure – Legal Insurrection Summer 2022 Fundraiser The evidence is quite clear: The Party is using Silicon Valley to censor Americans and even worse: they are being fired and banned from their industries because os social media censorship and labeling. How the CDC Coordinated With Big Tech To Censor Americans Covid has been the excuse, but it goes far beyond that. Smoking Gun: USG, Free Speech, Big Tech; The CDC colluded with Big Tech to prevent COVID "vaccine" informed consent Professor Jacobson has covered states' efforts to get the federal government to answer in court for their collusion with social media Judge: States Will Get ‘Expedited Discovery' On Biden Admin Collusion With Big Tech To Censor Conservatives; Missouri AG Eric Schmitt: “No one has had the chance to look under the hood before – now we do.” But, Silicon Valley continues to collude against independent voices Epoch Times: “Update: 16 hours later, @TwitterSupport has not responded to our case, and all of our content remains censored.” Facebook, Instagram Posts Flagged as False for Rejecting Biden's Recession Wordplay; "The fact-checking industry has become a partisan arbiter of political disputes," notes Phil Magness.See omnystudio.com/listener for privacy information.
On this episode of the Sex Therapy Podcast, AASECT certified sex therapist and sex therapist supervisor Natasha Helfer joins Dr. Caleb Jacobson to discuss how she was excommunicated from the LDS church and how she continues to work with Mormon clients.Plus, Dr. Jacobson responds to a woman who's boyfriend broke up with her because she lied about one of her past partners and he reviews the Namii from Biird.