Podcasts about Mast cell

Dr. Deb Muth 0:05What if your immune system isn’t broken, it’s just confused? What if chronic Lyme, the autoimmune condition, the food sensitivities, the exhaustion that never lifts what if those aren’t separate problems but one problem? A misfiring immune system that nobody taught how to stand down. Today’s guest has spent over 15 years doing exactly that, retraining the immune system from the inside out with a therapy so precise, so safe, and so effective that it has changed the lives of thousands of people who’d been written off by conventional medicine. Stay with me. This one changes everything.Welcome back to Let’s Talk Wellness Now, the show where we pull back the curtain on chronic illness, challenge outdated medical thinking, and hand you the real tools to heal from the inside out. I’m Dr. Deb, integrative and functional medicine practitioner, medical detective, and your straight-talking guide through the world of root cause medicine. Today, we’re going to dive deep into the immune system, specifically something called low-dose immunotherapy or LDI, and also into some hormones, chronic fatigue, and what it actually looks like to treat the cause instead of suppressing the symptoms. If you or someone you love has been told there’s nothing more we can do, this episode was made for you. Grab your cup of coffee, Settle in and let’s get to work. Now, before we bring in today’s guest, a quick word from our sponsor, and then we are diving straight in. I promise. Did you know sweating can literally heal your cells? Infrared saunas don’t just relax you, they detox your body, balance hormones, and boost mitochondrial energy. I’m obsessed with my HealthTech Sauna, and right now you can save $500 with my code at healthtechhealth.com/dr-muth-req-25.I want to start you with a story because this is one I’ve heard hundreds of times in my own practice, and I’m guessing you’ve either lived it or know someone who has. She’s 42. She’s been sick for years. Fatigue that doesn’t lift with sleep, joint pain that migrates, brain fog so thick she can’t finish a sentence, and a gut that seems to react to everything she eats. She’s been to her GP, rheumatologist, gastroenterologist, maybe even an immunologist, and every single lab comes back within quote unquote normal limits. She’s handed a prescription for something to manage the symptoms and sent home. Maybe she’s been told it’s anxiety. Maybe she’s been told it’s aging, or maybe and this one always breaks my heart she’s told it’s all in her head. That woman is not imagining it. She is not anxious and she’s not aging poorly. Her immune system has lost its ability to tolerate things it’s supposed to tolerate, and no one has offered her the therapy that could actually fix that. And what we’re talking about today with my guest has been practicing integrative medicine for over 15 years. Ty Vincent holds a medical degree from the University of Washington. He completed his family medicine residency in Anchorage, Alaska, and since has built one of the most impressive clinical repertoires I’ve seen anywhere in this field: acupuncture, Chinese medicine, environmental medicine, bioidentical hormones, hyperbaric medicine, chelation, regenerative peptide therapy, psychedelic-assisted therapy, and nutritional medicine.He lives and practices on the Big Island of Hawaii. He is married has 9 children. Oh my gosh, 9! And he has personally navigated type 1 diabetes, which, as you’ll hear, is not separate from his mission. It actually is his mission. And most importantly, he is a world authority on low-dose immunotherapy, a therapy he pioneered in 2008 and since has trained over 200 providers globally and changed the course of chronic illness care as we know it. I have had the pleasure of learning from Dr. Ty Vincent. I have had pleasure of taking his low-dose immunotherapy course when he first started back in like 2008 or 2009. I remember doing it back then and learning more about it in 2011. And this is going to be a great conversation for us. So one quick ask that I have for you guys, if this sounds like something that you want to learn more about and you’ve listened to some of our shows, please share like, subscribe. It means a lot. It helps us grow our channel. It helps us continue to provide for you different topics, different speakers, and really give you what it is that you’re looking for.So without further ado, I’d like to introduce you to Dr. Ty Vincent. All right, so Dr. Ty Vincent, this is gonna be a great conversation. We were just chatting before we went live of my training with you guys way back in like 2015, and I’m excited to hear all the new things that you’ve got going on. But introduce yourself to the audience. Tell us a little bit about you, how you got involved in this, uh, where you’re at, all that good stuff. Tyvincent 5:29Okay. I, uh, it’s a long story, but some of the highlights, I guess I was born in Alaska in the early ’70s and grew up there kind of wandering around in the woods with my dogs with no one around all day long. It was amazing. You don’t get kids don’t get that experience anymore. So you kind of learn to be an independent thinker, I think, you know, because latchkey kid, parents weren’t home till 6 and you’re on your own from early. Dr. Deb Muth 5:49That was a great time, wasn’t it? Yeah. Tyvincent 5:51I mean, I have, I have 9 children now and none of them grew up like me. And despite my effort, I mean, I’d have to basically like helicopter them out in the woods and drop them off for a few hours for them to understand what independent kids today are so dependent and parents are so helicopter that, uh, it’s changed. Anyway, I, I grew up just really liking science and really loving science, a huge nerd. And, um, and, uh, when I went into college, when I wanted to be a marine biologist and I thought that that was my passion of the ocean wildlife and all that, and then halfway through college, personal Couple things made me change my mind. It was a girl, you know, the usual. And I decided to go to school in Anchorage instead of going I was, I was transferring to Hawaii and I was going to study marine biology. And then, uh, my girlfriend moved back to Alaska where we were from. And I decided to do that instead. And then they didn’t have a marine science program.So I decided I’ll just get a biology degree and go to medical school. I’m a smart guy. I can do that, but I had no awareness of medicine. I really didn’t have any, you know, the passion some people have to be a healer and to go help people wasn’t part of the calculus at all for me. I was kind of an Asperger’s kid, so that really wasn’t the way I thought, honestly. And then I went into medicine and I was really interested in the science, the biology, the biochemistry, all the stuff, the physiology. And before I started medical school, I was reading some Andrew Weil’s books and I was, I decided to get a book on nutritional biochemistry because I naively thought that’s what they were going to teach me, right? This is how you make people healthy. You figure out how it works and you give them the things that make their body work right. Yeah. And we all know that that’s. Not been true for over 100 years now since the Flexner Report. And, you know, the rich people steered the government towards pharmaceuticals. Dr. Deb Muth 7:26Yeah. Tyvincent 7:26But that was my interest. And when I went through the first 2 years of medical school, I just really devoured all of the basic science stuff. And that was what I thought was the most important. And I honestly mastered all that. I scored in the top 1% in the country on all the exams and everything. And it was the top, in the top of my class at the University of Washington. And then you start doing clinical medical training and you discover that they don’t use any of that knowledge anymore, really, unless it pertains directly to pharmaceuticals, and that pharmaceutical research is extremely narrow and reductionist, and they only want to try to prove one little effect, and it doesn’t translate to real health. So as I got into clinical work and started residency, you know, by the third year of residency, I was like, they didn’t really teach me how to help people with chronic illness. You know, I was, I went to family medicine residency, so I was delivering babies.I was assisting with surgeries. I was in the ER. I was doing colonoscopies. I actually did colonoscopies in practice after residency, which family Doctors almost never get to do, but I’m a small town in Alaska. So I managed my own ICU patients and did everything, literally circumcisions in the office. And you’re dealing with like hospice and end of life care, just both ends, right? Pregnancy to death. And so I’d realized that if I really wanted to do the job well, which was my goal, I needed to learn other things. And in my, in my third year of residency, I actually did the extra, like, like additional training in medical acupuncture that was put on by the Helms Medical Institute then with Joseph Helms.And that was great. And I had to learn Chinese medical theory and I learned, I did the extra module on Chinese herbal medicine. And it was wonderful because I had to open my mind to a completely different way to evaluate people and illness. And I thought, okay, well then there’s got to be more. And as I went, I just became this voracious consumer of broad medical knowledge, not conventional medicine. You notice how a lot of the conventional people call it traditional medicine? Dr. Deb Muth 9:07Yes. Tyvincent 9:07Which annoys the crap out of me because there’s nothing traditional about something that’s been around for 100 years. I mean, you need time, you need like an epoch to say something’s traditional. But they’re like, no, I’m like, and then we were considered alternative medicine minded and everything like, oh, well, Well, it’s an alternative to real medicine. The vernacular in our culture really dictates thinking, unfortunately. I went on to learn functional medicine. So like 2005, I did the acupuncture training. 2006, I found the IFM and I read their entire textbook in a few months. And I went to the trainings. I was like, okay, now I know what you guys have to teach me. And then I found a bioidentical hormone therapy training course that was like Jonathan Wright and Terry Hertog. Dr. Deb Muth 9:46Terry Hertog, yes. My favorite guys. Tyvincent 9:49They were great. Dr. Deb Muth 9:50Pioneers, right? Tyvincent 9:51Yeah, exactly. And, you know, I learned what their opinions were and all that. And then you don’t really learn how to use a tool or you don’t get really get facile with something until you are using it and you’re applying it to your patients. And I went beyond that. I learned all kinds of IV nutrition. I learned chelation therapy. I joined the Environmental Medicine Academy and I learned how to do various forms of immunotherapy, eventually leading to learning LDA, low dose allergy therapy, through them in 2008. And for those of you listeners who don’t know about low-dose allergy therapy, when you learn about it, basically it’s like homeopathic dilutions of antigens.But instead of single antigens, like if you go to that regular allergist, they’ll just prick test you, blood test you, whatever, and say, oh, you react to mold, you react to chicken, you react to your husband’s whatever. They don’t test for that. I sometimes do. And they’re very narrow-minded about it. And it’s like you just give the antigens that the person tested for and you’re always missing something. With LDA, you get these huge broad mixtures of antigens, like for foods, it’s just hundreds of foods compiled into one for environmental allergens. And the reason you can get away with it is that the dilution factor is so far out. There’s no physical interaction with the body and you can’t, there’s no risk of inducing allergy, right? Whereas conventional shots might be 1,000 to 1, 100 to 1 dilution. We’re out at like a billion to 1 or further in most of these. And it sounded like nonsense to me, right? Despite all of my training I’d already had and all these things and being open-minded, it still sounded ridiculous. Pointless, right?But at least I was willing to give it a try because I had patients in my clinic, my family medicine clinic in Alaska, that had horrific allergies. Just like kids with eczema from head to toe. They look like they’ve been set on fire. Half their hair wouldn’t grow out of their head. They’re just miserable. They won’t grow. They’re on steroids. And I just thought, if there’s if this has any chance of working for these kids, I’m going to give it a try. Plus, two of my kids at the time had eczema, like persistent eczema that was really annoying. And I kids with eczema is a near and dear thing to me now. I like, I get emotional treating these kids, but, but that’s because it’s miserable for the families. Right. So I took it hard and I started treating my kids and, and, uh, kids in my clinic with LDA and it worked like magic because magic is just science we haven’t figured out yet. Right. We just, you know, some, but it was undeniable that it was working incredibly well. And then I was like, well, what is going on here? How does this work? And you learn the whole history of it. It goes back to the 1950s. I’m like, but, but it’s still so limited. There’s so much more as you start to treat patients with every tool in your toolbox, you run into these walls occasionally where you’re like, okay, everything I’m doing now isn’t working. And this patient has some kind of chronic inflammation, which is a very general term.People go, I have inflammation. Yeah, yeah. What we all do every day, all the time. But they would have these chronic inflammatory disorders that really seem to be immune driven. And then I thought, well, in terms of understanding low-dose allergy therapy, if I can identify what the target antigen really is that’s underlying this patient’s condition, and I can restore tolerance to that, which is basically how LDA works, then you could resolve it. And so I set about experimenting with all kinds of autoimmune disorders. I mean, at the time, LDA and the predecessor therapy called EPD, they had a few bacterial antigens, and we knew that there were connections between like rheumatoid arthritis and the bacterium Proteus. So that was in one. Klebsiella was the target antigen for ankylosing spondylitis. I’m thinking, well then, what about all these other autoimmune disorders? So I started just treating people creatively and trying all kinds of different things. Luckily, I had a contact in Orange County who had a warehouse, like a biomedical sample warehouse, and he was willing to give me antigen mixtures almost anything you could imagine in the biomedical world.The first thing I had him put together was Candida. I found those of us in the medicine space realize that some people have this huge problem with Candida. The conventional medical world thinks, well, yeah, everybody’s got Candida. That’s not a thing unless it’s an infection, blah, blah, blah. But you see these patients that are super ill, persistently ill, and you give them antifungals because you think, okay, well, you have these red rashes and itching and constipation and fatigue and muscle pain, blah, blah, whatever. It sounds like a yeast problem. Some of them, interestingly, if you do stool analysis, they show no yeast on their stool, which is a clue to me with a different thinking process that the reason the yeast isn’t growing in their stool is their immune system must be attacking it and killing it off in the gut, right? Because who doesn’t carry Candida? So the, the tests that run those are the stool company the test the companies that run the stool test, they don’t flag that result as abnormal because, yay, good, you have no yeast. But it’s horribly abnormal, right? Like if you saw somebody with no, no ears, you’re like, that’s not right. And so I thought, well, maybe they’re immunologically hypersensitive Candida. And so I, I was able to purchase a mixture of Candida species. And it occurred to me that I should include Saccharomyces cerevisiae in there because baker’s yeast and brewer’s yeast, people become sensitive to that too.So I made this and some of the patients that I was seeing where I would put them on Diflucan and Nystatin and all their symptoms would just evaporate, right? But you try to stop the medications after a month or whatever, and within 48 to 72 hours, their symptoms are right back. And that was one of the things, another clue to me, like, well, then that’s not an infection. I mean, they’re not taking antibiotics. They’re not eating a ton of sugar. Why would this regrow? And one of my criticisms of our integrative medicine world is we have just as many fairy tales and dogmatic beliefs as the conventional medical world. They’re just more colorful. Dr. Deb Muth 14:59That is true. That is very true. Yeah. Tyvincent 15:01And people were saying, oh, well, it’s because Candida lurks and hides in these nooks and crannies and corners in your body. And I’m like, I’ve done colonoscopies for years. I don’t know what you’re talking about. Like, it’s sparkling clean in there after some Go Lightly or whatever you torture your patient with the day before a colonoscopy. I was like, well, that doesn’t make sense. And they’re like, well, it’s because Candida uses mercury as a weapon to fight off your immune system. I’m like, you’re anthropomorphizing this organism as if it had agency to make tools, right? It doesn’t make sense. So then I came up with this idea to desensitize people to Candida. And it was incredibly effective.These patients, when you find the right dilution, you know, and for those who don’t know, it’s just a couple of drops of water put under your tongue, taken out of a syringe from multiple different dilution steps of the mixture, whether they’re using, right? So these people would respond. Most things I’ve developed, people respond. Somewhere near a trillion to one mathematically. And it was incredible. And I was like, okay, this is something that I’m sure relates to other chronic illness problems. And I started experimenting with I had a couple of patients with inflammatory bowel disease, ulcerative colitis, both of them early on. That was 2009. And I was like, well, they didn’t respond to the yeast mixture. They didn’t respond to the food mixture. And I was like, well, they’re reacting to something.And presumably that something is living in their gut. Right? I now know people react to different bacteria. There’s a ton of different bacteria and other organisms in your stool. So I came up with the crazy idea after seeing Dr. Bill Ray at an environmental medicine meeting talk about what he called autologous vaccines. Dr. Deb Muth 16:29Right? Tyvincent 16:30And I want to be clear, the way a vaccine works is probably the total opposite of how LDA works. It’s not the same thing. You’re restoring tolerance with LDA, LDI, and you’re promoting a robust immune reaction to a target antigen with a vaccine. At least that’s the theory. And now I’m not. It’s true. But Dr. Ray was talking about that and I thought, well, that’s a cool idea. And I went up and I asked him like, how do you do this?How do you make these things? And he kind of gave me like a very brief, you know, brush off. He didn’t know me very well. He’s like, oh, you get these Millipore filters, these little things you put on a syringe and you can dilute something and pass it through into a vial and it’ll be a sterile solution and you can dilute it. I was like, oh, great. So I collected one of my ulcerative colitis patients’ stool who was having at the time like 12 bloody bowel movements per day, every day. He’d seen all the conventional gastroenterologists. He tried the different drugs. They weren’t working. He went to some really special integrative greater clinic in California that primarily dealt with gastrointestinal disorders, and he did everything they wanted him to do, and it also didn’t help.I did discover that he was sensitive to gluten, and when he went off gluten, his, his gut still didn’t improve. So I made this autologous stool, um, LDA I called it then, which now I change it to LDI because LDA is a proprietary term and it’s also very narrow in scope. And I gave him doses and looked like the second dilution maybe that I went through hit. Literally his, his diarrhea and bleeding stopped overnight. And by 3 days he was having completely normal stools and no pain, nothing. And that taught me a couple of things. One, this theory works, right? And two, you know, we talk about the concept of leaky gut in the alternative medicine world, like integrative medicine world, sorry, a lot.And I’m like, yeah, but that’s not a diagnosis. That’s a symptom. You know, you still figure out what’s causing inflammation. And people are like, I just have leaky gut. It’s chronic. And you know, what do you do? And what I found was if you just put the fire out, the house rebuilds itself. Health very quickly. You know, we know that the lining of the gut turns over extremely fast. That’s why it is one of the first things to go when you do chemotherapy. And these people were basically healed to normal within less than a week. Same thing with kids with eczema that had these horrible oozing, weeping skin patches. Dr. Deb Muth 18:25I would. Tyvincent 18:25Or psoriasis even. When I developed some things that would treat psoriasis later on, you, you give this person with just, you know, deforming sort of rashes the right antigen, within 3 to 5 days they have normal looking skin except for maybe residual depigmentation or scarring if but it just blew me away. Dr. Deb Muth 18:42That’s crazy. 3 Days. Tyvincent 18:44The key to solving these problems was to restore immunological tolerance for the thing that it had lost tolerance for. Dr. Deb Muth 18:50Right. Tyvincent 18:50And it just really made me think about everything we were taught about chronic illness and everything we’re taught about the immune system in a very different way. And so since 2009, I’ve developed I’ve continued to develop new mixtures for new things because I run into patients. I can treat so many more things now highly successfully than I could before, but there’s still always the failures. People would ask me over the years, you know, why did you pick up all these skill sets?Like I learned acupuncture and Chinese medicine. I learned bio I became a Reiki master even, because I’m like, well, energy is a thing too. And so I get into the energy medicine world and that also works. And especially if you add it to acupuncture, it’s a great combination. All this stuff. And I would still fail. And I, it occurred to me when people ask me the question, like, I’m driven by failure. I really don’t like it. And I said, uh, and I thought that was how everybody believed, you know what everybody thought, right? But then you when you study our conventional medical colleagues and a lot of our people in the integrative medicine world too, that are doing the same things, the same protocols.And I hate the word protocol because it’s a poor substitute for thinking, right? It’s so that you don’t have to think here, follow this list, but everybody’s so different. So I never developed a protocol for anything to this day. I don’t, that’s not what I do. I was like, despite all of this, their patients aren’t getting better either. And it’s like, well then, you know, just philosophically, which I was a big philosophy student in college too. I thought if, if what you’re doing doesn’t work, do something different, you know, make new mistakes, figure things out. And I just got really creative. And by now I have, my gosh, I have 100 different kinds of antigen mixtures. And to be very honest, half of them have never worked for anything because that’s how it works, right? You got to. Dr. Deb Muth 20:17You’re trying it. Geez. Yeah. Tyvincent 20:19You’ve got to be willing to be wrong if you ever want to be right. One of the things I’ve noticed about humans in general is they’re very unwilling to see when they’re wrong because it’s emotionally painful to let go of something that has maybe been a part of your self-identity or especially like when you get experts in a field and they’re famous for some theory or treatment or whatever they developed, even if evidence shows up later, which it inevitably does, to show that what they’re doing isn’t complete, maybe not wrong, but not complete, there’s huge resistance, right, to the change. Dr. Deb Muth 20:49No one will admit that there’s something that didn’t work initially when they thought it did. Tyvincent 20:54Right. And nobody wants to admit I’ve been doing something wrong or ineffective or less than it could be for 20 years. You know, that’s unsettling. But to me, I’m like, well, isn’t it worse to keep doing it wrong? Right? Dr. Deb Muth 21:06That’s the whole idea. Like, right? We’re supposed to be bettering ourselves. Medicine’s supposed to be adapting and changing, and we don’t. Like, there’s a lot of things that we still do the same way we did in the 1950s and ’60s. Cancer treatment is one of them, right? We don’t really do anything different than we did back then. And when you look at precision medicine, we have all these new tools, but people stay stuck in their way of doing things just because maybe it’s easier, they’re comfortable or whatever. It doesn’t always make it the best interest for the client. Tyvincent 21:36No. And that is the goal we all need to keep in mind. Dr. Deb Muth 21:38Yeah. Tyvincent 21:39What I thought was like the job is to fix the problem the person has. And if the tools you currently have don’t do that, you need to learn something else. Dr. Deb Muth 21:48Yeah. Tyvincent 21:48And eventually I got a little saturated with learning new things. Dr. Deb Muth 21:51I’ve been there. Tyvincent 21:54Turns out there’s a limit. You know, we use the term drinking from the fire hose for everybody who like comes, like conventionally trained doctors who first get into the integrative medicine world. You’re just like, what are you talking about? It’s all so foreign and new. And then you have to use it and realize, okay, there’s, there’s a lot of truth here. But I got to a point where it’s like, I just don’t have the time in my day to use every tool. Like I bought an Indigo machine. I don’t know if you’ve heard of it. So the old EAV technology from Germany long ago, electrodiagnostic things and Then they developed computer programs and software that could analyze 11,000 different frequencies. It’s all energy frequency based. And I bought one of these for like $25,000. I still have it in the case collecting dust because I just didn’t have time to learn how to use the tool. And I was like, all right, I got to just get really, really good at some things and then let my colleagues who are good at other things help people with the things I can’t treat and I’ll tell them where to go. You know, it’s a collective, it’s a team effort. Dr. Deb Muth 22:47Right. It’s got to be a team effort. I’m curious what you’re finding these days with the newfound for mass cell, right? MCAS, everybody’s problem child, and nobody has a good answer. And it’s, it’s an immune reaction, right? It’s not just that I’m allergic to everything situation. Back in the day, 20 years ago, you and I would have called these the chemically sensitive people, and now we at least understand what’s going on. It’s an immune reaction. But I’m curious what you’re finding with LDI and that population of people. Tyvincent 23:19It’s a really good question. I know, I know you’ve had other interviews where people have discussed it philosophically to start the conversation. I really have found over the years that a diagnosis is the least helpful thing you can give your patient. Dr. Deb Muth 23:31Agreed. Tyvincent 23:31But we love labels. We love names. And we, and the problem is when you give something a name that does not reflect what’s actually going on, it just leads everybody’s brain in the wrong direction. And so there’s nothing wrong with these people’s mast cells. And that’s why I’m like, I despise the term mast cell activation disorder, but It is okay that they may be the end of the line releasing histamine and whatever, but a lot of these people have tons of inflammatory symptoms that have nothing to do with histamine, right? There are lots of mechanisms in the immune system that can give you cell-mediated inflammation or humoral, like antibody-mediated inflammation, different things. And mast cells are kind of an IgE thing, but it’s way more complicated than that.And when you work with these people, because a lot of them have found me because they have a very difficult time finding answers and solutions. I’ve been at most of us in this field have been at the bottom of a funnel where the options decrease because you try more and more therapies and they don’t work and the desperation increases kind of inversely proportionally. And then they’re trying weirder and weirder things that like people think are bizarre, you know, like you can eventually sting yourself with 20 bees a day, do apitherapy or something. Dr. Deb Muth 24:36I remember that therapy. And you know, as a practitioner too, it becomes more and more frustrating because it’s like, I’m trying all these things and nothing is working. What am I missing? And you keep trying different things until they just give up on you or you give up on them or whatever ends up happening, you know. Tyvincent 24:52Right. But again, like philosophically, every failure should lead you a step closer to success. Dr. Deb Muth 24:58Yeah. Tyvincent 24:58If you can look at it and you can learn from it what is possible from it and go, okay, I got to do this different or change this, or perhaps my entire theory about this problem is just dead wrong. Yeah. So if what I think is happening isn’t what’s happening, what else could be happening? And then you, you know, you come up with a theory and then you have to devise a way to test test it. And so like a lot of people probably tossed around theories about things being immune related or whatever over the years because it becomes a little obvious at a certain point, but they didn’t have a tool to test the theory.So that was the, the unique position I found myself in from 2009 onward was I’ve got a way to test this if I can figure out what antigen to try. And so I got a lot of mast cell people with that diagnosis. And, you know, my assessment of the problem is that when they come into my office, because like you and like most of people that are kind made it a little further in the integrative medicine world. The patients that find you have already seen 20 of your colleagues at the Mayo Clinic and the Cleveland Clinic and Germany, like Mexico, whatever. They’ve had exosomes infused up their nose or whatever. Like, all right, so what has not been explored yet? And you got to realize, okay, these, these people are there’s something going on. It’s very inflammatory. It’s probably immune related, but where is it coming from? Again, you mentioned root cause. You’ve got to trace the steps backward and try to figure out where is the point of intervention that will actually work and that’s feasible. And so what I found in these people, most of them have a pretty common early story of having had one or a few immune reactions that first began the process. And they might’ve been fairly benign and not that big of a deal.And then they go through some kind of immunological stress, whether it’s, well, some kind of stress, whether it’s a direct immune stress, like a vaccination or an infection or something like that. Like with COVID I’ve had an equal number of people who developed chronic immunological disorders after having the virus infection or having the vaccine. And the things that develop are virtually identical. So people are like, I should be gotten the vaccine. I’m like, it really doesn’t make any difference. Dr. Deb Muth 26:53Right. And I’ve seen the same thing with the HPV vaccine too. Like a lot of young people, they get that and all of a sudden their whole system is torn off after that. It’s very common. Tyvincent 27:03Except in that example, just getting HPV doesn’t do it. It’s the vaccine that does it. Dr. Deb Muth 27:07Vaccine that does it. Yes, exactly. Tyvincent 27:10Because everybody’s got HPV, you know, some other, and that is not in and of itself enough of an inflammatory trigger to lead to these chronic illness, right? You can lead to cancer, sure. Which is focal and it’s not a hypersensitivity problem. It’s a failure of immune defense problem. It’s a little different. So I would get these people and I’m like, okay, what happened first? What’s the beginning of the story? Because if you talk to them about how they’re feeling today, and a lot of your listeners, this will resonate with them. If I ask you how you’re doing today, the real cause of your problem is buried under a snowstorm of constant inflammation and your life experience is utter hell. And you have no clue what’s really triggering anything anymore. It’s like at a certain point, the immune system has developed PTSD, right? It’s just, it’s hypervigilant. Anything you give these people to take, even like vitamin C or whatever, then they go, ah, it made me worse.Ah, it made me worse. Because their immune system is now seeing anything foreign as an invader, as an enemy. So if you ask people just about how they’re doing today, you get absolutely nowhere. With these people. The one theory I had though was, well, maybe they’re reacting to histamine itself. Okay. I think is a beautiful theory. Makes total sense. Didn’t work at all. Spoiler alert. It’s not that it doesn’t work. It’s easy to get a sample of histamine, you know, and I also, I also got histidine, the amino acid from which it’s derived. I’ll say I’ll just put them together. So at least I want to say 12 years ago, I made like a histamine histidine LDI and everyone who had kind of the mast cell picture portfolio of illnesses, I would try it on. It has to this day, it’s never worked for anybody that I’ve tried it on. And I haven’t had another LDI practitioner tell me that it did. But again, that failure made me think about it in a different way. And so the success I’ve had with that population is not monolithic. It’s not one part. From an LDI perspective, figuring out what it is that they began to react to first, like, did you still have, do you have food problems originally?Oh yeah, I was kind of sensitive to gluten, but I just ate it anyway because I would just get some diarrhea and some, okay, it it was, it was livable, right? But they just keep exposing themselves to this trigger. And eventually something snaps in their immune system. Like they live in a moldy dorm room for 6 months and that all of that immune activation will kick off whole new immune response problems. And the world of mold is another area where I think people don’t, do not really understand what’s going on. And a lot of our treatment approaches don’t work for a large portion of these people. And it has to be kind of thought of in a broader sense. They could go through a divorce. They could have a car accident. They could have a surgery. A woman could have a baby, which is one of the biggest immunological triggers, unfortunately, is having a baby or early pregnancy miscarriage even is enough to do. Emotionally stressful. It’s physically stressful. It’s immunologically stressful.And then it swings your estrogen back up and you get this hypersensitive profile. But so all of these, what I call catalytic events were common in these people. And it’s not just one, it’s any one of them. And what I found was if I could identify what their initial triggers were categorically, right? Environmental things, chemical things, food. And if I could desensitize them to those, everything would settle down. And, and that was, that’s been the key to working with those people. But they want to tell you how horrible their life is today. Dr. Deb Muth 30:17Yeah. Tyvincent 30:17And you got to listen to that because you need the connection. You need to understand what they’re dealing with. You need to understand what their baseline is so that you can compare going forward. But the answers, the solutions aren’t in that story. And the solutions are in the history. And like, what’s the first thing you remember? And all this, like, okay, well, let’s go with foods. Let’s go with chemicals, whatever. And if somebody has distinctly worst triggers, right? Because right now they react kind of to everything. Any foods that you absolutely don’t eat because they give you the absolute worst reaction pattern, right? Oh yeah, I can’t eat these things. They’re the worst. Okay, well, maybe we’ll start with those and you can use those foods as your test exposures to determine if the dose works each time. So that’s one of the things I’ve developed stylistically over the years is the use of a test exposure if we’re using an allergen extract so that you can confirm or deny whether the therapy worked, right? Because people will tell you, oh, I feel better.Turns out that’s not worth much. You really need like, I mean, And belief is a huge part of that. Placebo effect is a huge part of that. You want to find something relatively objective, you know, so will you still vomit when you have chicken? You know, cause that’s like, that’s pretty obvious. And then go with that, you know, or do you still get a rash when you put on a bandaid? I love it when people get rashes from contact cause they can show me pictures and it’s not subjective, turns out. But even those reactions can go away 100% with placebo doses. It’s fascinating how people respond to placebos. So anyway, I try to find like the root beginning allergens. And then a lot of these people also accumulate other target antigens as they go through their process of being ill. Their immune system is so upset and it’s, it’s also just blurry vision, right? It attacks anything. Angry dog on a chain. If you get close enough, it’ll bite you. It doesn’t care who you are. And that’s how their immune systems get.So finding the antigens that are root cause is key. But a lot of these people have developed over time total adrenal burnout. Out, right? Because they’re in state of chronic inflammation, everything. So I also found that I had to lean on my skill in bioidentical hormone therapy, which over all the years I’ve been in integrative medicine, the two major skill areas that gave me the best results in general were hormonal management and immunological modulation. I got so many of the prior failures I was able to solve with those two things. And so if I would support these people’s adrenal, like hormones, you know, DHEA, cortisol, to optimal levels, a lot of them, their symptoms would cut by half, number one. And you would have a little more clarity as to what their actual triggers were.So in a lot of these cases, I learned to start with that before I even decided what antigens to pick. You can kind of get the snowstorm to calm down. You can start to find the snowmen in the blizzard that you couldn’t see before with all the chaos. I was like, okay, now that you’re feeling better most of the time, you can tell that these chemicals bother you, that mold exposure bothers you, that whatever, and then you can target things But the other third kind of leg of the tripod that I found are the keys to success with our most complex patients is to address like the hormonal issue, the immunological issue, but the subconscious fear response, the subconscious stress response in them. Dr. Deb Muth 33:14Trauma. Tyvincent 33:15And I saw that you’ve also people, yeah, trauma and people have medical trauma, not just trauma from their illness itself, but trauma from seeing 12 doctors that treated them like they were a head case and ignored what’s going on. Dr. Deb Muth 33:25Of the medical community, right? Tyvincent 33:27Oh God, you know, like people— yeah, the more doctors you see, the more your trust in doctors goes down. Dr. Deb Muth 33:34Yes, exactly. Tyvincent 33:35They see one of us and some of them just automatically are like, whatever, here’s another failure coming my way, kind of thing, you know, realistic. Partly because it becomes too risky to have hope, right? Like after a while you’ve had hope, hope, and it’s been dashed, and you just can only handle that so many times. It’s like you fall in love and then they dump W. And after a while you’re like, I’m celibate. I don’t care anymore. Um, so you get these people and what we have found, my wife and I started doing psychedelic-assisted therapy with patients a few years back. In fact, this little cottage on my property we built specifically for that purpose. People can come and stay here for a couple of days.There’s a bedroom on the other side of this wall. And we do therapy with them. We have a very good process of getting their hormones tested before they come, trying to correct any deficiencies or imbalances, especially cortisol and DHEA. We try to make sure that if they have immune problems that seem manageable, we maybe try to control those first. But in a lot of these people, we have to get their subconscious fire alarm to go off first because anything new that enters into their sphere of existence is seen as this, you know, scary thing. Dr. Deb Muth 34:36Yeah. Tyvincent 34:36And so what we found is getting their subconscious to settle down, getting them to integrate past whatever trauma they’ve had so that it’s no longer causing harm today from an experience 20 years ago, right? Because that’s not fair. A lot of these people, all of their immune stuff stops and I don’t even have to do LDI. And that’s fascinating. And some of them, we put them on hormone replacement, everything calms down enough. It’s like one of these things sometimes works. And in other people, they need all three. And the trick in those people is to figure out what thread you have to pull on first. You know, it’s like, well, okay. And we spend a lot of time, my wife and I both work with patients together. She’s amazing. She’s not a trained clinical clinician. You know, she had a business degree, but she’s like, she tells people I attended the school of Dr. Ty Vincent for 10 years. Dr. Deb Muth 35:20Yes. Tyvincent 35:21Heard him say all this a million times. And when we first started seeing patients from home together, she read all of my patient notes and just great. So she. Dr. Deb Muth 35:28Yeah, that’s how you learn. Tyvincent 35:30Yeah. And people like, well, I didn’t go she’s like, I didn’t go to medical school. I’m like, that’s an asset, trust me. Dr. Deb Muth (35:34-35:40)Exactly. Oh my God, you haven’t been brainwashed. Exactly. Tyvincent 35:40And you know, it’s not even so much washing as it is like throwing mud all over the walls. All of these false beliefs you’re given, and, you know, not just the beliefs, but the disbeliefs, both of those hold people back. And I was like, it’s your disbeliefs that are the bigger problem because you don’t even realize they’re there. Like when I learned about LDA, I’m like, that’s nonsense. No, it’s not. Dr. Deb Muth 36:02I’m curious, when you treat some of these complex people with LDI, are you using multiple modalities at one time, or are you being really cautious with them and using one at a time? Time, because some of them won’t let you do more than one thing at a time with them. Tyvincent 36:16And so by modalities, you mean like, are we also doing hormone therapy? Are they also doing like IV, like other things? Or you mean multiple antigens within? Dr. Deb Muth 36:24Multiple antigens, yeah. Tyvincent 36:25Um, it really depends. And early on, so I everything I know about LDI, I learned through experience, paying attention, putting connecting dots over you. And it’s been been a very long process, right? Early on, like a kid in a candy store, you see a patient and you find out, oh, they’re allergic to some foods, they’re allergic to some chemicals, they’re allergic to cats and birch tree pollen, and they also have psoriasis or whatever. And you’re like, ooh, I’m going to give you all 4 of these antigen mixtures because you have all 4 of these issues. And by 6 months in, if you’re paying attention, you are completely confused and lost. Dr. Deb Muth 37:03Yeah. Tyvincent 37:04I did that for a number of years and I thought, well, this will be the fastest way to figure things out. It turns out it’s not, unfortunately. Um, what I’ve found is more successful is if I can figure out either what the most important underlying immune reaction is for them that might be cascading into other problems, or you figure out what’s the easiest one to solve first. So if somebody has like the whole mast cell picture and they got all this stuff going on, but they say the biggest thing is I have horrible chemical reactions. I’m a tr I’m trapped in my home. I created an oasis of safety here, but I can’t go anywhere. Anyone who comes to my house has to go into the entryway and take all their clothes off and put on a jumpsuit, right? There are those people. I work with them. Dr. Deb Muth 37:40Oh yeah, I have those clients. Tyvincent 37:42They’re like, oh my God. Well, if we can fix that first, your world will open up a ton. Your fear will come down. Your immune response will come down. And so sometimes it’s a matter of which one seems the most important or which one seems easiest. Like, okay, the test exposures that they have are the most obvious and distinct. For foods and not chemicals or whatever. And the reactions people have to these different antigens can overlap tremendously or even look exactly the same, which is why you kind of need to use one at a time. Because if you’re trying to ride a bike and a motorcycle at the same time, it doesn’t go so well. Dr. Deb Muth 38:16Yeah. Tyvincent 38:16Like, let’s find where you do with where you respond to this one, and then we will have less stuff to deal with. We might have a little bit more clarity as to what you’re reacting to in other categories. And then you kind of go through them sequentially. But if I have somebody who’s not like just in a real state of immunological distress like that, and they go, yeah, I’m allergic to cats and I have a cat because I’ll never get rid of my cat. I don’t understand those people, but, but there are a lot of them. They love their cats. Dr. Deb Muth 38:43A lot of them. Yes. Tyvincent 38:44I’m like, okay, or dog, you know, I’ve had people that are horribly allergic to dogs and the dog still sleeps in bed with them every night. Dr. Deb Muth 38:50Okay. Tyvincent 38:51Um, they’ve got that, that’s very clear, very distinct. And it’s, and it’s like a rash or a runny nose. And then they also have have celiac disease, let’s say. Like, well, we can treat both of those at the same time because the symptoms are totally different. You have test exposures in both categories and you’re not so sick that you’re in a constant state of like trauma response where you can’t even pay attention to anything. Right. And so it’s kind of case by case. And my style is very, very individualized. Like I said, there’s never a protocol. It’s like, I got to talk to people for about I usually talk to people for about an hour. Yeah. More than isn’t really helpful. You know, like, in an hour of time, you’re, you’re kind of saturated with how much you can invest your bandwidth into this particular issue. Now, like, okay, I know where we’re going to start. I don’t know where we’re going to end up, but I know where we’re going to start. And so we encapsulate that and then go, let’s do this. And then everything you do teaches you more about what else you need to do.And it’s a process. I my ego used to be more tied to guessing correctly at the beginning about what was going to work work and to fixing things quickly. And over time I realized like your ego really has no place in the exam room. Like that is a very, very challenging thing for practitioners to try to figure out is how to get your ego out of this because it biases you intellectually, emotionally, and it’s a problem. And our medical colleagues probably have bigger egos than the average human in the population. Let’s be honest. Um, there’s something that comes with the years of study and the investment and the status you have, and it’s a challenge. But if you be like, I just need to be clear about what’s happening, what’s not happening, and you figure things out. And so I was able to have a much better success rate approaching things that way.And every time you put out one little fire for people, one kind of immune response, it, you, you get a better picture about what else is going on. And then eventually all their problems have stopped and you’re okay, cool. I guess we’re done. But it’s, it’s hard. And you do learn that there are still major gaps in your knowledge. And, and you asked earlier about new developments in LDI. And whatnot. And I could literally talk all day about the things that I’ve developed over the years, but I still keep making new antigens. So just last year in the area of food allergy, so like your Mast Cell people, a lot of them have food allergies that are a big part of the underlying problem, and this will be relevant to them. But what I found is a lot of the people who seem to clearly react to food, and I put food in quotes because most of what Americans eat isn’t food, right? It’s it’s at least it’s not just food, or it used to be food and now it’s not. It’s like Frankenfood, and it’s got chemicals in it. It has molecules that don’t exist in nature, so you can react to them.So I found some of these people that would say, oh, I react to processed food items horribly, but if I eat the whole foods, organic whole foods at home, I don’t react. And, um, some of those people will resolve those problems with the chemical LD mixture. So they’re reacting to chem with that. A lot of them will tell you, oh, I also react to perfume. Or gasoline or whatever. Dr. Deb Muth 41:46Yeah. Tyvincent 41:46Okay. And so you can use that and some of those cases will resolve, but a lot of them don’t. And I had increasing failures. Like I’ve been doing this long enough to see and observe that early on I had much better success with these antigen mixtures than over time. People are the pattern and the causes and the manifestations of illness today are evolving right before our eyes because of what we’ve done to our environment and our food and ourselves. So what I came to to sort of theorize about was that maybe some of these people are reacting to processed cooking oils, like seed oils, plant oils that are put into processed foods, right? Because they would tell me a couple of key cases gave me that insight. They would say, well, I still react to all these processed foods.I can’t eat at restaurants, and I’m still reacting horribly to sesame seeds, or I’m still reacting horribly to flax, or I’m still reacting horribly to, like, one of these other things we make processed seed oils from. Well, maybe they’re reacting to the oils. And when we made the food mixture, you use whole food samples, right? So you use like a, a ses like sesame seeds, or I use tahini paste because it’s easier to mix in water. But maybe the antigen, the target antigen, is something inside that that is not properly like, what’s the word I’m looking for properly given to the immune system, or, or like exposed, shown to the immune system, right, in the way that their immune system is reacting to it. Maybe it’s a molecule in there that when you use a whole food antigen is not adequately represented. It’s like, so an oil would do that.And I had actually already years ago realized that some people react to essential oils, like flower extracts or tea tree oil or lavender or whatever. Right. And so I made an essential oils mixture from plant oils from the doTERRA and the Young Living products. I had a couple of patients that were like distributors for these things. And I said, just take an empty vial and put one drop of every single product you have in it and just mail it to me. And they both did that. So I have this huge compendium of essential oils, and I would get people that would still react to oranges and lemons and citrus fruits despite the food mixture. And then the essential oils mixture would totally stop that reaction. So I’d already kind of proven that this was the case with some of those more aromatic oils, right? Now I was like, well, people are reacting to the processed cooking oils because when you take oils out of the plant, if you ever do this at home, they’re opaque and gooey and viscous. And then somehow it’s this really pretty homogeneous, clear liquid that doesn’t separate at all. It has no nothing you see in there.And then you got to wonder, how the hell did they do that? What did they do to make that? And there are all these chemical processes and heat and everything. I’m like, well, it just makes new molecules that your immune system has never seen before. So in May of 2025, I bought 18 different kinds of plant oils, and some of them are really pure, like carrot seed oil, cottonseed oil. But there’s peanut oil and avocado oil and olive oil and, you know, all the seeds and things we use in there. And I even have a video on our Facebook page and probably Instagram of me making this mixture in my kitchen.I was like, people are kind of interested how this works. And I just made it right there on camera because it’s really simple. I started using it in some of my failure cases that had really seemed like they had food allergy responses, but the food mixture didn’t work. And the first one was actually one of our employees who does our social media management. She had a 3-year-old son, I think, probably 2 years old when we started working with him, with really bad body-wide eczema, right? And he never really responded to the food mixture, essential oils, skin bacteria, skin fungi, yeast. I tried all the things that usually work. I’m like, it’s something. And so he made the oil mixture. He was they were the first one. I just sent the doses like, hey, let’s check it out. And I think he got for I started 6C for most things, which is a truly and then it’s like 5.5C, 5C. We got to 3.5C, I think, is where he is, which is a dilution of of 10 million to 1, I believe. And 95% of his eczema just completely went away. Dr. Deb Muth 45:38Wow. Tyvincent 45:39The only thing left was a couple of those patches on his feet. And one of the things I learned about people with eczema is they will have localized, like geographically local consistent reactions to different things. This is crazy, right? Dr. Deb Muth 45:53Yeah. Tyvincent 45:53Your immune system has kind of a, you know, like an overall regulatory system, but it also has regionalized systems, just like the government federal government, state government, county government, city government. It’s, it’s divided like that. So the people will eventually learn, oh, if I eat gluten, I get these itchy bumps on the side of my hand, and if I eat carrots, I get a rash on top of my head, you know. And it’s very, very clear once you identify it. So there’s still something that kid’s reacting to that I haven’t quite solved on his feet. But, um, yeah, that worked amazingly, and it actually made me cry when I got the pictures She’s like, oh, finally, after probably a year and a half of flailing, you know, we got it right. And so now I’ve been using the cooking oils mixture more and more and more. Just yesterday I got an email. I have a teenager, he’s 8, he’s maybe 18, 17, 18, with just really horrible cystic acne, painful, erupting. And the before pictures are just hard to look. I mean, he’s got horrible involvement of both sides of the face, the chest, all over his back, and you can just see the scarring and the redness and the inflammation.And we went through the food mixture with him and whatnot, and it really didn’t touch it. So yesterday I got the report. He got up to the cooking oil mixture at 2.5C, which is 10,000, 100,000 to 1, and, and his cystic acne stopped. Like, he’s getting zero new lesions. All the redness, pain, inflammation is gone, but he still has all this just scarring from it because that’s permanent, right? You have to get that repurposed. And all he has left is little tiny whitehead pimples, like maybe one new one per day here and there. You can see them now in the midst of all this. So acne is diversified. There are different kinds of acne and people can have more than one type and they can react to hormones. They can react like I’ve had guys with bad acne respond to desensitization with testosterone, for example, or women desensitizing them to estrogen or progesterone and the acne will go away sometimes. Some people respond to yeast, some people respond to skin bacteria, skin fungi. And so this is another thing. And my wife actually is one of the more complicated immunological cases I’ve ever had to work with. Working together for 10 years, um, you know, like the first time I saw her, she had Lyme disease and the Lyme LDI just totally stopped those symptoms like magic, which is great.That’s one of my favorite things to treat. Um, because the beliefs we have about Lyme disease, I have found completely untrue because using a different tool. I’m like, oh, it’s an immune problem, not an infection. So anyway, so that, that worked for her. Some of her food reactions went away, but she still continued to get like deep painful cysts if she would have nuts or dairy. And so the cooking oil mixture now, after 10 years of being together, totally stopped those reactions. Peanuts, nuts, dairy. And the dairy one is interesting to me because it’s not a plant oil, right? It’s an animal oil and it’s not represented. And we have dairy products in our other mixture. But I think what’s happening is when cows are fed grain, sometimes what an animal is eating carries through some essence or nature of that substance into the milk. Um, and the thing I’ve seen this the most clearly with is corn. Corn allergy is a very unique situation. The way people deal with it, the way it manifests, the way you have to treat it is different from every other energy. And I don’t have an hour to talk about that specifically, but I observed primarily with corn that anywhere along the food chain, you’ll still react to that food if the animal at the beginning was ever fed corn. Multiple I’ll have babies that get an eczema reaction or a GI reaction if mom eats corn-fed beef. But if mom eats grass-fed beef and then nurses the baby, they’re fine. Dr. Deb Muth 49:33Yeah, I’ve seen that too. Tyvincent 49:34It’s bizarre. Dr. Deb Muth 49:35Yeah. Tied. This has been really so amazing. Um, tell us how people can find you if, if this is resonating with them and they’re like, I need him to figure out the puzzle for me. How do they find you? Tyvincent 49:49So the best thing to do is to go to our website. Our, our business name is Global Immunotherapy, and the website is just http://www.globalimmunotherapy.com. We have, we have a much better website than we did years ago. People schedule directly through the website. Right? There’s all kinds of information. I’ve been making YouTube videos and informational videos for people for more than a decade now because nobody has any idea what I’m talking about. The more they understand it beforehand, one, they get to decide if they just think I’m crazy, right? And they don’t want to waste their time. And there are plenty of those people, but a lot end up talking to me 3 years later because after they’ve tried everybody else and there’s nothing left to try, right? Yeah, yeah, like being at the bottom of the desperation funnel. Yeah, people like, well, I heard about you 5 years ago and didn’t make sense. I’m like, yeah, cool. But then I had 3 or 4 other people over the years tell me I should talk to you. So here I am. That’s, that’s right. And people can watch all these educational instructional videos about how LDI works, what it can be used for. So the more you learn and understand what you’re getting into ahead of time, the less time we have to spend during our hour trying to explain to you the therapy., which to take up half the time and better results you’re going to get because you’re educated and it’s a partnership.Like all of us in the world of integrative medicine, one of the big differences between us and conventional medicine is we understand that it’s a partnership. You have to listen to the patient, you have to educate the patient, you have to engage them in their own health. You can’t just say, here, take this pill and come back in 3 months and I’ll check your labs again to see that you still have the same illness. It’s just and people have a lot of our population has been led to believe that just swallowing a pill is going to fix your problems. But That doesn’t work. And we have to develop a relationship and an understanding and shared knowledge and beliefs. And so people now, they have this opportunity to watch all the videos. And I really want people to do that before they ever schedule, because one, you’ll, you’ll feel like it’s the right therapy for you. And that helps a lot. Having optimism going in is super helpful. And then two, you already know a lot. So you’ll know more about what questions I might ask you and how to answer them. You’ll know more about about how the therapy works, and I won’t have to explain it to you, and we’ll get a better use of our time. And then people can schedule right through the website with either myself or my wife Jeanette. And anybody who Jeanette talks to, she reviews every case with me, and we work together with stuff. And, but in terms of like using LDI, she’s probably the second or third best practitioner in the world. I

Dr. Sandra Kaufmann is back for round two. She's the creator of the Kaufmann Protocol, author of three books on the science of aging, and a longevity physician. In addition to her clinics in Miami and Las Vegas, she also runs Club Exosome, a quarterly gathering of longevity fanatics she calls a modern French salon.This is a conversation for anyone who wants to understand not just what to take, but also why and how to think about longevity at a level that actually moves the needle.— Episode Chapter Big Ideas (timing may not be exact) —0:00 — Intro2:49 — Club Exosome: what it is and why she calls it a French salon3:29 — What she still believes from round one and what she's added 4:30 — Heterochromatin distribution: her new DNA obsession 5:30 — Why circadian rhythms are strictly biochemical 6:32 — Mast cells: why they increase with age and why that matters7:48 — Iron toxicity: the silent accumulator nobody talks about9:05 — Clean bloodwork but still at risk: how iron hides in your tissues10:06 — The plague theory: why your ancestors' iron storage may be killing you slowly12:09 — How to actually test for tissue iron accumulation12:57 — Why giving iron to older patients with low blood iron is often the wrong call13:39 — Aspirin as an iron chelator: the colon cancer connection15:06 — High intensity exercise and iron recycling16:25 — Natural chelators: wheatgrass, quercetin, astaxanthin, aspirin17:31 — Blood donation as a longevity tool, especially for men on testosterone18:28 — Hematocrit and stroke risk19:09 — Exosomes: what they are and how they work at the cellular level 20:57 — Where exosomes come from and why source matters 22:52 — When to start using exosomes and how they compare to PRP 25:26 — Exosomes vs. stem cells: the key differences and why she prefers exosomes 27:43 — Exosomes as an amplifier 28:52 — Mast cells beyond allergies: the aneurysm and heart attack connection 30:26 — What mast cell degranulation is actually doing to your collagen 31:29 — Being allergic to stress: the cortisol-mast cell receptor connection32:01 — Natural mast cell stabilizers 38:48 — Estrogen for men: why trying to eliminate it is a bad idea40:14 — The estrogen algorithm she's building and what it will cover43:37 — Glycation vs. glycan age: what's the actual difference44:36 — HbA1c and skin autofluorescence as glycation markers45:43 — Epigenetic clocks: interesting data, limited decision-making value47:26 — Her actual assessment framework: what labs she starts with 48:01 — Grail liquid biopsy vs. full body MRI: why she wants both51:31 — Tests she wishes existed: sirtuin levels and intracellular NAD51:56 — Sirtuin hierarchy: which ones matter most and what activates them56:06 — Her current pharmaceutical stack and why1:03:37 — The question she's trying to answer next— Connect With Dr. Sandra Kaufmann —Website: https://kaufmannlongevity.com Instagram: https://www.instagram.com/kaufmannlongevity Book1: The Kaufmann Protocol: Why We Age and How to Stop It — https://www.amazon.com/Kaufmann-Protocol-Why-Age-Stop/dp/0692089047/Book 2: The Kaufmann Protocol: Aging Solutions — https://www.amazon.com/dp/B0B5MVFBVQBook: Kaufmann Longevity Treatise Series, Volume 1: Mastering the Mast Cell — https://www.amazon.com/Kaufmann-Longevity-Treatise-Mastering-Mast-ebook/dp/B0GSX7BXL1— Connect with Julian and Executive Health —LinkedIn — https://www.linkedin.com/in/julianhayesii/X — https://x.com/thejulianhayesDon't let your biology become the bottleneck to the enterprise you're building. Book a private call —https://www.executivehealth.io/contact***DISCLAIMER: The information shared is not meant to treat or diagnose any condition. This is for educational, informational, and entertainment purposes. The content here is not intended to replace your relationship with your doctor and/or medical practitioner. Consult your provider before making any decisions.

Summer can bring unique challenges for people living with Mast Cell Disease. From heat and travel to outdoor activities, how can you enjoy the season while managing symptoms? Join us as we sit down with content creator and patient advocate, Jenna Gestetner, to share practical tips for navigating summer with confidence. Resources to keep you in the know:Mast Cell Disease SocietyFAACT's Allergy SummitJennaXHealthInstagram: JennaXHealthTikTok: JennaXHealthYouTube: JennXHealthLinkedIn: Jenna GestetnerYou can find FAACT's Roundtable Podcast on Apple Podcasts, Pandora, Spotify, Podbay, iHeart Radio, or wherever you listen to podcasts.Follow us on Facebook, Instagram, BlueSky, Threads, LinkedIn, Pinterest, TikTok, and YouTube.Sponsored by: Blueprint MedicinesThanks for listening! FAACT invites you to discover more exciting food allergy resources at FoodAllergyAwareness.org!

In this episode of the IRH Clinician's Corner, we're presenting a special panel discussion from our recent Clinical Success Showcase event in January. Host Kristin Whitaker is joined by a powerhouse panel of master practitioners as they break down what histamine intolerance really means, why symptoms like skin issues, gut problems, brain fog, and anxiety are showing up more frequently in practice, and how the world around us might be fueling this trend. You'll learn the spectrum of histamine-related disorders, the known drivers behind these conditions—from chronic infections and toxic exposures to hormonal swings and even trauma—and, most importantly, practical, foundational strategies to help calm symptoms, restore balance, and support your clients or yourself. In this interview, we discuss:   The critical role mast cells and histamine play in immune function, inflammation, and symptom development. How to recognize the often-overlooked symptom patterns associated with histamine intolerance and mast cell activation. Why these conditions are becoming increasingly common and the environmental and lifestyle factors that may be contributing. The powerful relationship between histamine, estrogen, and hormone-related symptom flares throughout a woman's cycle. The most common root causes driving histamine-related symptoms Practical tools for calming the histamine response, supporting recovery, and helping clients expand their diets with confidence. The Clinician's Corner is brought to you by the Institute of Restorative Health. Follow us: https://www.instagram.com/instituteofrestorativehealth/   This episode is brought to you by the Clinical Success Showcase, happening June 1–4 from the Institute of Restorative Health.  Join practitioners from across the industry for four free days of real clinical case studies, expert panels, and practical conversations designed to help you think more systematically and confidently in practice. From pediatric eczema and mood concerns to male hormones, complex chronic cases, and optimizing outcomes for clients on GLP-1 therapies, each session is built around real-world application you can actually use with clients. The Clinical Success Showcase is proudly brought to you by LeadCalculators, Evexia Diagnostics, MRT: A Superior Approach to Managing Diet-Induced Inflammation, and BetterBloodTest.com.  Register free and save your spot today. Timestamps:  00:00 Preview of histamine intolerance panel 09:22 Discussing oncology nutrition certification 14:17 Understanding symptom increase factors 20:25 Discussing mysterious symptoms and triggers 23:14 Understanding histamine intolerance 27:42 Balancing complexity and simplicity in health 33:28 Chronic inflammation and hormones discussion 40:06 Explaining the histamine bucket analogy 45:22 Managing food sensitivities and fear 54:18 Discussing antihistamine trial periods 59:02 Knowing when to refer clients 01:01:23 Advice for new health practitioners 01:10:05 Managing Histamine Intolerance Symptoms 01:14:01 Discussing mast cell stabilizers 01:17:47 Engaging with the panel discussion Speaker bios:  Ellen Lovelace, MPH, FNTP, MRHP is a Master Restorative Health Practitioner and faculty member at the Institute of Restorative Health who brings nearly 20 years of experience in public health and functional nutrition. Sara Fields, FNTP, MRHP is a Master Restorative Health Practitioner and faculty member at the Institute of Restorative Health who specializes in gut health, fertility, and helping clients uncover the root causes of chronic health concerns. Min Kim, NTP, MRHP is a Master Restorative Health Practitioner who helps clients uncover root causes, interpret complex health patterns, and create practical nutrition strategies that support long-term wellness. Keywords:  Clinician's Corner, functional health, histamine intolerance, mast cell activation syndrome, MCAS, mast cell disorders, root causes, gut health, autoimmune conditions, mental health, sleep issues, hormone fluctuations, perimenopause, menopause, estrogen dominance, chronic inflammation, mold exposure, long covid, chronic infections, GI MAP test, Dutch Test, MRT food sensitivity test, DAO enzymes, low histamine diet, antihistamines, H1 blockers, H2 blockers, nervous system support, dietary strategies, trauma and health, client intake forms Disclaimer: The views expressed in the IRH Clinician's Corner series are those of the individual speakers and interviewees, and do not necessarily reflect the views of the Institute of Restorative Health, LLC. The Institute of Restorative Health, LLC does not specifically endorse or approve of any of the information or opinions expressed in the IRH Clinician's Corner series. The information and opinions expressed in the IRH Clinician's Corner series are for educational purposes only and should not be construed as medical advice. If you have any medical concerns, please consult with a qualified healthcare professional. The Institute of Restorative Health, LLC is not liable for any damages or injuries that may result from the use of the information or opinions expressed in the IRH Clinician's Corner series. By viewing or listening to this information, you agree to hold the Institute of Restorative Health, LLC harmless from any and all claims, demands, and causes of action arising out of or in connection with your participation. Thank you for your understanding.  

Your relationships are reshaping your biology in ways that diet and exercise alone cannot fix, and the science behind it will change how you think about longevity, metabolism, and what it actually means to be healthy. Watch this episode on YouTube for the full video experience: https://www.youtube.com/@DaveAspreyBPR Host Dave Asprey sits down with Dr. Molly Maloof, a physician and one of the most innovative voices in personalized medicine, functional medicine, and human performance. Since 2012, she has advised or consulted for over 50 companies across digital health, consumer health, and biotechnology. She pioneered a course on healthspan at Stanford University and founded Adamo Bioscience, a company dedicated to unlocking the science of love as a pathway to healing and human connection. Dr. Maloof brings a rare combination of clinical depth, biohacking credibility, and entrepreneurial range to one of the most overlooked conversations in longevity. Together, Dave and Dr. Maloof dig into the neurobiology of love and attachment, the hormonal drivers of the sex drive and pair bonding, and how chronic isolation wrecks your metabolism at the cellular level. They explore the cell danger response and how toxic relationships, mold exposure, and trauma can lock your cells into a self-protection mode that blocks healing. They also cover psychedelics as hormetic tools, oxytocin as nature's medicine, the placebo response, peptide therapy for mitochondrial repair and anti-aging, and why regenerative medicine is about to rewrite the rules of human lifespan. If you are serious about biohacking your body from the inside out, this episode is essential. You'll Learn: Why human connection is a biological necessity, not a lifestyle preference, and what isolation does to your mitochondria and metabolism How the three neurobiological drives of sex, romantic love, and attachment are wired into your hormones and what happens when they go wrong What the cell danger response is, why it gets stuck, and which peptides, supplements, and therapies help break the cycle How oxytocin drives wound healing, immune function, and the placebo response Why psychedelics work as hormetic love drugs and how they reproduce the neurobiology of romantic love The top peptides for mitochondrial repair, brain optimization, and telomere biology Why Dave and Dr. Maloof believe we have already reached longevity escape velocity How AI is accelerating precision medicine, protein folding breakthroughs, and the future of anti-aging therapeutics Why fasting, breathwork, neurofeedback, and somatic therapies all converge on the same biological reset mechanism How to build the adaptive capacity and bioenergetic reserves to bounce back from anything Thank you to our sponsors! - Danger Coffee | Grab yours at DangerCoffee.com and use code DAVEPOD at checkout for 15% off. - Amp | If you're ready to make fitness fit into your life, go to amp.ai to check it out - Puori | Go to Puori.com/DAVE or use code DAVE at checkout to get 32% off your Puori Fish Oil subscription. You save more than $18 - Our Place | Stop cooking with toxic cookware and upgrade to Our Place today. With a 100-day risk-free trial, plus free shipping and returns, you can experience this game-changing cookware with zero risk. Visit: fromourplace.com/DAVE Use code: DAVE for 10% off sitewide Dave Asprey is a four-time New York Times bestselling author, founder of Bulletproof Coffee, and the father of biohacking. With over 1,000 interviews and 1 million monthly listeners, The Human Upgrade brings you the knowledge to take control of your biology, extend your longevity, and optimize every system in your body and mind. Each episode delivers cutting-edge insights inhealth, performance, neuroscience, supplements, nutrition, biohacking, emotional intelligence, and conscious living. New episodes are released every Tuesday, Thursday, Friday, and Sunday (BONUS). Dave asks the questions no one else will and gives you real tools to become stronger, smarter, and more resilient. Keywords: Dr. Molly Maloof, Adamo Bioscience, Stanford University, personalized medicine, functional medicine, healthspan, longevity, biohacking, human performance, anti-aging, regenerative medicine, longevity escape velocity, cell danger response, mitochondria, mitochondrial health, oxytocin, vasopressin, dopamine, serotonin, neurobiology of love, attachment theory, pair bonding, sex drive, hormone replacement therapy, testosterone, estrogen, menopause, andropause, libido, female sexual dysfunction, relationship biology, social health, isolation, community, co-regulation, trauma healing, psychedelics, MDMA, psilocybin, ibogaine, ayahuasca, hormetic stress, social hormesis, neurofeedback, 40 Years of Zen, breathwork, nervous system regulation, HPA axis, cortisol, mast cell activation, histamine, long COVID, mold exposure, phospholipid therapy, glutathione, vitamin C, BPC-157, TB500, SS31, epothilone, SELANK, SEMAX, BDNF, telomere biology, telomerase, peptides, GLP-1, placebo response, wound healing, metabolism, continuous glucose monitoring, gut health, AI, precision medicine, supplements, brain optimization, neuroplasticity Resources: • Grab Molly's Book The Spark Factor: https://www.amazon.com/Spark-Factor-Supercharging-Optimizing-Feeling/dp/0063207206 • Learn More About Dr. Molly's Work: https://drmolly.co/ • Visit Your Healthspan Journey: https://yourhealthspanjourney.mystrikingly.com/ • Get My 2026 Clean Nicotine Roadmap | Enroll for free at https://daveasprey.com/2026-clean-nicotine-roadmap/ • Dave Asprey's Latest News | Go to https://daveasprey.com/ to join Inside Track today. • Danger Coffee: https://dangercoffee.com/discount/dave15 • My Daily Supplements: SuppGrade Labs (15% Off) • Favorite Blue Light Blocking Glasses: TrueDark (15% Off) • Dave Asprey's BEYOND Conference: https://beyondconference.com • Dave Asprey's New Book – Heavily Meditated: https://daveasprey.com/heavily-meditated • Join My Substack (Live Access To Podcast Recordings): https://substack.daveasprey.com/ • Upgrade Labs: https://upgradelabs.com Timestamps: 00:00 – Trailer 00:28 – Intro 01:39 – COVID Isolation & Its Effects 03:11 – Science of Love & Hormones 04:24 – Psychedelics & Love Chemistry 09:22 – Cell Danger Response 11:07 – AI, Tech & Human Connection 13:20 – Social Connection as Medicine 20:50 – Placebo, Care & Psychedelics 24:49 – Altered States & Healing Modalities 30:09 – Peptides & Longevity Drugs 35:44 – Mast Cell & Personal Health Challenges 43:46 – Regenerative Medicine & The Future 46:17 – Longevity Escape Velocity 50:05 – Outro See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

Your cells start failing at 35. Dr Sandra Kaufmann reveals the 7 systems breaking down — and how to stop it. Your cells start failing at 35. Dr Sandra Kaufmann reveals the 7 systems breaking down — and how to stop it.

When your symptoms shift daily and no one, not even your doctor, can give you clear answers, the hypervigilance can feel like the only rational response. But what if that constant scanning is actually making your nervous system harder to calm, and there's a way to work with it instead of against it?In this episode, you'll hear from Dr. Amanda Whitehouse, licensed psychologist specializing in anxiety and trauma related to food allergies and mast cell conditions. She reframes nervous system regulation not as a reset button, but as a slow, trust-building process, and explains why that distinction matters more than most people realize.Connect with Destiny:  Instagram / Facebook / Website______________________________

Ready to find out why you can't sleep and get a step-by-step, customized plan to fix it? Schedule a consultation to get started with the Complete Sleep Solution program: https://p.bttr.to/3VJwvDsOver the years working with people who struggle with chronic insomnia, I started noticing a pattern. Some clients who wake up around 2 or 3am often experience things like sudden anxiety at night, temperature changes, skin symptoms, or a racing heart. And those symptoms often point to something most sleep advice never talks about.In this episode, I'll walk you through:How mast cell activity and histamine can wake your body up in the middle of the nightWhy it often happens around 3:00 AMHow to calm mast cells so you can stay asleep00:00 Why You Wake at 3AM01:06 A Client Pattern Emerges01:56 Immune System Not Stress02:04 Quick Program Break02:39 Mast Cells Explained03:30 Histamine as Wake Signal04:14 Why It Peaks Overnight04:44 Menstrual Cycle Connection05:02 What You Can Do05:22 Dinner and Histamine Foods05:59 Calm Your Nervous System06:25 Supplements for Histamine07:08 Fix the Root Causes07:41 Wrap Up and Next Steps

In this episode of the Healing Powers Podcast, host Laura Michelle Powers speaks with medical doctor and functional medicine expert Dr. Kelly McCann about mast cell activation syndrome (MCAS), histamine intolerance, and the growing number of people experiencing unexplained chronic symptoms. Although mast cell activation was only first described in medical literature in 2007, research suggests that up to one in five people may be affected.Dr. McCann explains how mast cells—an important part of the immune system—can become overly reactive due to environmental toxins, mold exposure, infections, stress, and trauma. When this happens, it can trigger widespread inflammation throughout the body and lead to symptoms such as allergies, brain fog, digestive issues, insomnia, migraines, anxiety, and fatigue. Laura also shares her own experiences with mold exposure and sensitivities, highlighting how many people struggle to get answers through conventional testing.Learn more about Dr. Kelly McCann at thespringcenter.com As Dr. Kelly referenced, you can find more information and locate mold-aware professionals through the International Society for Environmentally Acquired Illness (ISEAI): https://iseai.org/Kelly K. McCann, MD, MPH is a triple board-certified physician in Internal Medicine, Pediatrics, and Integrative Medicine, with additional certifications in Functional Medicine and Medical Acupuncture. She is the founder of The Spring Center in Costa Mesa, California, where she specializes in complex chronic illness, including Mast Cell Activation Syndrome, mold and mycotoxin illness, Lyme disease, and environmentally acquired conditions.Dr. McCann has hosted multiple international summits on MCAS and allergy-related illness and serves on the boards of the American Academy of Environmental Medicine and was a founding Board member of the International Society for Environmentally Acquired Illness. A graduate of Tulane University School of Medicine and one of only 35 physicians worldwide to complete the residential fellowship at the University of Arizona's Center for Integrative Medicine, she also holds a Master's in Spiritual Psychology.Her work is now evolving into what she calls The Unforgetting Project: a new healing paradigm that bridges functional medicine with spiritual psychology, inviting patients to experience symptoms not as failures, but as meaningful messages guiding them back to wholeness.Laura is a Celebrity Psychic who has been featured by Buzzfeed, The Weakest Link, Beast Games, NBC, ABC, CBS, FOX, the CW, Motherboard by Vice Magazine and the #1” Ron Burgundy Podcast” with Will Ferrell. Laura Powers is a clairvoyant, psychic medium, writer, actress, producer, writer, and speaker who helps other receive guidance and communicate with loved ones. Laura travels nationally and internationally for clients, events, television appearances, and speaking engagements. She is also the author of 7 books on the psychic realm and 1 book on podcasting. Laura also works as a psychic, entertainer, and creative entrepreneur.For more information about Laura and her work, you can go to her website www.healingpowers.net or find her on X @thatlaurapowers, on Facebook at @realhealingpowers and @mllelaura, and on Instagram, TikTok and Insight Timer @laurapowers44.

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Why do so many Lyme patients stay sick — even after treating infections, detoxing, and “doing everything right”?In this episode of Integrative Lyme Solutions, Dr. K sits down with functional and environmental medicine pioneer Dr. Kelly McCann to explore why Lyme disease, mold toxicity, and Mast Cell Activation Syndrome (MCAS) are rarely just infections — and why true healing requires addressing the terrain of the body, nervous system, emotions, and spirit. Drawing from her own journey through mold illness and Lyme disease, Dr. McCann explains how immune dysregulation, trauma, limbic system activation, and cell membrane damage keep patients stuck in chronic illness.This conversation dives deep into mast cell activation, mold exposure, Bartonella, phosphatidylcholine therapy, biofilms, nervous system regulation, emotional trauma, spirituality, and why symptoms are not betrayals — but messages. If you've been gaslit, dismissed, or feel like your body is working against you, this episode offers validation, insight, and a radically different way to understand Lyme healing.Key Takeaways:0:00 Introduction and Dr. Kelly McCann's personal healing journey3:00 Mold exposure as a hidden driver of chronic illness6:20 Lyme, Bartonella, and the overlap with mast cell activation9:30 Why siloed medicine fails complex chronic disease patients11:40 Phosphatidylcholine and cell membrane repair explained13:50 When antimicrobial treatment stalls, look beyond infections16:50 Mast cell activation, trauma, and nervous system dysregulation18:40 The limbic system's role in chronic illness21:10 Emotional trauma, immune boundaries, and people-pleasing24:00 Language, identity, and separating yourself from disease26:10 Terrain theory and why healing requires self-honoring choices29:00 Illness as an invitation, not a punishmentResources Mentioned:Dr. Kelly McCann – https://drkellymccann.comThe Spring Center – https://thespringcenter.comThe Unforgetting Project – https://unforgettingproject.comMicroGen DX (Next Generation Sequencing) – https://microgendx.comByron White Formulas – https://byronwhiteformulas.com _______________________________The Karlfeldt Center offers the most cutting-edge and comprehensive Lyme therapies. To schedule a Free 15-Minute Discovery Call with a Lyme Literate Naturopathic Doctor at The Karlfeldt Center, call 208-338-8902 or email info@TheKarlfeldtCenter.comCheck out Dr. K's Ebook: Breaking Free From Lyme: A Comprehensive Guide to Healing and Recovery here: https://store.thekarlfeldtcenter.com/products/breaking-free-from-lymeUse the code LYMEPODCAST for a 100% off discount!

In this episode of Derms and Conditions, host James Q. Del Rosso, DO, welcomes Lauren Madigan, MD, associate professor of dermatology at the University of Utah, for a focused exploration of mast cell disease, an often underrecognized but clinically significant group of disorders that dermatologists may encounter on the front lines. The conversation begins with mast cell biology, including their origin in the bone marrow, tissue-specific phenotypes, and roles beyond classic allergic disease. Dr Madigan explains how mast cells contribute to immune defense and wound healing, with Dr Del Rosso noting how infrequently they are discussed in routine dermatology training despite their relevance across multiple conditions. They then explore mastocytosis across the age spectrum, contrasting pediatric presentations (many of which remit by adolescence) with adult-onset disease, where cutaneous findings often signal systemic involvement. Dr Madigan reviews current National Comprehensive Cancer Network guidance, emphasizing that most adults presenting with cutaneous mastocytosis will have some degree of systemic disease and may warrant more detailed testing for accurate staging, prognostic differentiation, and management choices. The discussion highlights the heterogeneity of systemic mastocytosis, from indolent forms to advanced disease with organ involvement or associated hematologic neoplasms. The episode also covers practical diagnostic and workup considerations, including laboratory evaluation, KIT mutation testing, and biopsy considerations. Dr Madigan stresses the importance of experienced dermatopathology interpretation and thoughtful site selection to optimize diagnostic yield. Treatment strategies are discussed through a pragmatic lens, ranging from symptom-directed therapies to cytoreductive and targeted tyrosine kinase inhibitors, with an emphasis on individualized care based on disease subtype, symptomatology, and prognosis. The episode closes with resources to help dermatologists navigate diagnostic assistance and treatments via specialty centers and clinical trials. Listen to the episode to deepen your understanding of mast cell disease, sharpen your diagnostic approach, and gain practical guidance on evaluation, staging, and management strategies, both for real-world practice and for determining when referral to specialized care is warranted.

What if the random symptoms you've been told are "all separate" – the hives, exhaustion, brain fog, and digestive chaos – are actually ALL connected through one dysfunctional system in your body that affects 1 in 5 people? When Dr. Tania Dempsey left traditional medicine after being told she wouldn't get bonuses for patients with cholesterol over 200, she discovered something revolutionary: conditions like fibromyalgia, chronic fatigue, long COVID, and mysterious autoimmune markers might all trace back to the same source: dysfunctional mast cells. In this conversation, Dr. Dempsey reveals why your mast cells (your body's security guards) might be stuck in overdrive, leaking over 1,200 different inflammatory chemicals throughout your body. She explains why perimenopausal women and adolescents are hit hardest, how hormones trigger these cellular explosions, and why that positive thyroid antibody test might not mean what you think. Most shocking? The conventional medical system's approach of treating symptoms separately might be exactly what's keeping you sick. Dr. Dempsey shares her personalized protocol that's helping patients reclaim their lives, but warns that you can't supplement your way out of this without addressing one crucial system everyone overlooks. If you've been gaslit by doctors, told your labs are "normal" despite feeling terrible, or you're navigating mysterious symptoms that worsen with hormonal changes, this conversation will help everything make sense.   Catch the full episode on YOUTUBE HERE: https://bit.ly/MidlifeConversationsYouTube    Learn More About Dr. Tania Dempsey   Instagram ➜ https://www.instagram.com/drtaniadempseymd  Website ➜   https://drtaniadempsey.com/    Thank you to our show sponsors! TIMELINE: Timeline is offering 20% off your order of Mitopure! Go to https://timeline.com/NATALIEJILL Free Gifts for being a listener of Midlife Conversations! Mastering the Midlife Midsection Guide: https://theflatbellyguide.com/ Age Optimizing and Supplement Guide: https://ageoptimizer.com   Connect with me on social media! Instagram: www.Instagram.com/Nataliejllfit Facebook: www.Facebook.com/Nataliejillfit   For advertising inquiries: https://www.category3.ca/  Disclaimer: Information provided in the Midlife Conversations podcast is for informational purposes only. This information is NOT intended as a substitute for the advice provided by your physician or other healthcare professional. Do not use the information provided in this podcast for diagnosing or treating a health problem or disease, or prescribing medication or other treatment. Always speak with your physician or other healthcare professional before making any changes to your current regimen.  Information provided in this podcast and the use of any products or services related to this podcast does not create a client-patient relationship between you and the host of Midlife Conversations or you and any doctor or provider interviewed and featured on this show. Information and statements may have not been evaluated by the Food and Drug Administration and are not intended to diagnose, treat, cure, or prevent ANY disease. Advertising Disclosure: Some episodes of Midlife Conversations may be sponsored by products or services discussed during the show. The host may receive compensation for such advertisements or if you purchase products through affiliate links. Opinions expressed about products or services are those of the host and/or guests and do not necessarily reflect the views of any sponsor. Sponsorship does not imply endorsement of any product or service by healthcare professionals featured on this podcast.  

Mast Cell Activation Syndrome (MCAS) is one of the most misunderstood drivers of chronic inflammation, fatigue, and hypersensitivity. In this episode, I break down what MCAS actually is, why it develops, and how to stabilize it. You'll learn the full physiological sequence behind mast cell activation, the real triggers: mold, infections, hormones, trauma… and how to restore regulation through nervous system work, nutrients, and drainage. This episode is science-heavy, systems-based, and practical,  everything you need to finally understand what's happening in your body.   Hosted by Leanne Vogel.   Root Cause Group Coaching program: https://p.bttr.to/3SqUExb    Coaching and other supports available at: https://shop.healthfulpursuit.com/    Podcast Sponsors, links and offers available at: https://www.healthfulpursuit.com/podcast/  Bioactive Peptides: https://www.healthfulpursuit.com/make

Clonal mast cell disease is often missed because symptoms vary from person to person, tryptase levels can be normal, and bone marrow biopsies are hard to get. For some people, unexplained or very severe anaphylaxis may be an early sign of a clonal mast cell disease. In this episode, we review “Prevalence of KIT D816V in anaphylaxis or systemic mast cell activation,” published in October 2025 in the Journal of Allergy and Clinical Immunology. This paper, known as the PROSPECTOR trial, is looking at how often the KIT D816V mutation can be found using a blood test in adults who have had anaphylaxis or systemic mast cell activation symptoms. We break down why KIT D816V matters, how it connects to systemic mastocytosis, why HaT needs to be considered, and how newer blood tests may help doctors catch clonal mast cell disease earlier. What we cover in our episode about KIT D816V and anaphylaxis: Setting the stage: Understanding mast cell activation and anaphylaxis. Why KIT D816V matters: How this mutation fits into clonal mast cell disease, what blood testing can reveal, and when doctors still turn to a bone marrow biopsy. Making sense of tryptase and hereditary alpha-tryptasemia (HaT): Why baseline tryptase, the “20% + 2” rule, and HaT can make screening more complicated than it seems. What the PROSPECTOR trial uncovered: How often KIT D816V appeared in people with anaphylaxis, and other results on tryptase and HaT. How this helps patients: What these findings mean for anyone with unexplained or severe anaphylaxis, and how doctors combine KIT testing, tryptase, HaT, and symptoms to decide on next steps. Other podcast episodes about mast cell disease: Ep. 127: Management of indolent mastocytosis - A clinical yardstick Ep. 126: Management of mast cell activation syndrome - A clinical yardstick Ep. 121: Avapritinib vs Placebo in Indolent Systemic Mastocytosis - PIONEER Trial Ep. 118: The ISM Disconnect - Do Patients and Providers Agree on Symptom Control? Ep. 70 How do stress and low histamine diets impact mast cell disease? Ep. 63: Mast Cell Diseases & Systemic Mastocytosis: The Basic Science Ep. 65: The Symptoms and Triggers of Mast Cell Disease *********** The Itch Review, hosted by Dr. Gupta, Kortney, and Dr. Blaiss, explores allergy and immunology studies, breaking down complex research in conversations accessible to clinicians, patients, and caregivers. Each episode provides key insights from journal articles and includes a one-page infographic in the show notes for easy reference. *********** Made in partnership with The Allergy & Asthma Network. Thanks to Blueprint Medicines for sponsoring today's episode.  This podcast is for informational purposes only and does not substitute professional medical advice. Always consult with your healthcare provider for any medical concerns.

Living with Mast Cell Activation Syndrome (MCAS) requires constant awareness and preparation—but what happens when you hit the road or board a plane? We're joined by content creator and patient advocate, Jenna Gestetner, who's sharing her top strategies and favorite tips for traveling safely and confidently with MCAS. Resources to keep you in the know:Mast Cell Disease SocietyFAACT's Allergy SummitJennaXHealthInstagram: JennaXHealthTikTok: JennaXHealthYouTube: JennXHealthLinkedIn: Jenna GestetnerYou can find FAACT's Roundtable Podcast on Apple Podcasts, Pandora, Spotify, Podbay, iHeart Radio, or wherever you listen to podcasts.Follow us on Facebook, Instagram, BlueSky, Threads, LinkedIn, Pinterest, TikTok, and YouTube.Sponsored by: ARS PharmaThanks for listening! FAACT invites you to discover more exciting food allergy resources at FoodAllergyAwareness.org!

On this episode Lara and Vyanka talk to Dr Frank Siebenhaar from the Charité University Hospital Berlin all about mast cell disorders. This is ImmunoTea: Your Immunology Podcast, presented by Dr Lara Dungan and Dr Vyanka Redenbaugh. This is the show where we tell you all about the most exciting research going on in the world of immunology. So grab a cup of tea, sit down and relax and we'll fill you in. Contact us at ImmunoTeaPodcast@gmail.com or @ImmunoTea on twitter. Hosted on Acast. See acast.com/privacy for more information.

It could be a bug bite. Or a harmless fatty lump. But it might be a mast cell tumor. In this episode of the VetFolio Voice podcast, we delve into mast cell tumors in dogs, including the unpredictable nature of these tumors, nuances around interpretation of cytology and histopathology reports, cytologic grading accuracy, and options for therapy including surgery, chemo, radiation and Stelfonta, an injectable mast cell tumor treatment for dogs. You'll learn about staging considerations and the role of newer prognostic panels as well as strategies for client communication about mast cell disease.

In this enlightening conversation, Dr. Kelly McCann discusses the significance of mast cell activation syndrome and its growing prevalence in today's world. She explores the intricate connections between environmental toxins, autoimmune diseases, and emotional well-being, emphasizing the importance of holistic approaches to health. Dr. McCann shares her personal journey through health challenges and highlights the need for awareness regarding mold exposure and detoxification. The discussion also touches on the impact of midlife transitions on purpose and joy, encouraging listeners to reconnect with their true selves and speak their truth for better health. Time Stamps: (00:29) Understanding Mast Cell Activation Syndrome (06:29) The Link Between Autoimmune Diseases and Mast Cells (08:43) Allergies: The Role of Maternal Exposure (11:39) The Interconnection of Mind, Body, and Spirit (18:11) Midlife Transitions and Purpose (21:22) Dr. McCann's Journey to Holistic Medicine (25:39) Understanding Lyme Disease and Mold Exposure (28:41) The Impact of Environmental Factors on Health (30:51) Mold and Weight Loss Resistance (33:59) Detoxification as a Key to Weight Loss (37:20) Testing for Toxic Substances (41:23) The Connection Between Truth and Health (48:28) The Unforgetting Project: Embracing Joy and Purpose ------------------- Website: https://drkellymccann.com Instagram: https://www.instagram.com/drkellymccann/ Instagram: https://www.instagram.com/thespringcenter/ Facebook: https://www.facebook.com/drkellymccann/ ------------------- Instagram: https://www.instagram.com/carolcovinofitness/ -------------------- My YouTube Channel: http://youtube.com/@carolcovinofitness -------------------- My Book: FINDING PURPOSE IN THE PAUSE

Dr. Brooke Britton discusses degranulation events—a scary potential when a dog has mast cell tumors. Learn what degranulation is, why it happens, and how it can affect your dog. Also: practical tips for managing symptoms, potential connections between allergies and cancer, and how to care for dogs with mast cell tumors. Topics Discussed: • What is a degranulation event? • How mast cell tumors cause degranulation • Symptoms dogs may experience during a degranulation event • The role of allergies and chronic inflammation in mast cell tumor risk • Medications and treatments to manage symptoms • Low-histamine diets and their role in comfort care • Tips for preventing future mast cell tumor growth • The importance of early detection and regular vet check-ups Your Voice Matters! If you have a question for our team, or if you want to share your own hopeful dog cancer story, we want to hear from you! Go to https://www.dogcancer.com/ask to submit your question or story, or call our Listener Line at +1 808-868-3200 to leave a question. Related Videos: https://www.youtube.com/watch?v=Al7jjCXVhuE https://www.youtube.com/watch?v=6eb4GrcH_f8 Related Links: Our article on mast cell tumors: https://www.dogcancer.com/articles/types-of-dog-cancer/mast-cell-tumors-in-dogs/ Chapters: 00:00 Introduction 01:15 What Are Mast Cell Tumors? 02:30 The Role of Mast Cells in Normal Immune Response04:00 What Happens During a Degranulation Event?06:45 Symptoms Dogs May Experience During Degranulation09:00 How Dogs Might Feel During Degranulation Events11:00 Stomach Upset and Ulcers in Dogs with Mast Cell Tumors13:00 The Link Between Allergies and Mast Cell Tumors16:00 Managing Allergies in Dogs to Reduce Risk18:30 Diet Considerations: Low-Histamine and Commercial Diets22:00 Medications for Degranulation Symptoms: Benadryl and Tagamet25:00 The Truth About Diet and Cancer Prevention27:30 Why Balanced Diets Are Key for Dogs with Cancer29:45 Closing Thoughts on Degranulation and Mast Cell Tumors34:00 Outro: Support and Resources for Dog Owners Get to know Dr. Brooke Britton: https://www.dogcancer.com/people/brooke-britton-dvm-dacvim-oncology/    For more details, articles, podcast episodes, and quality education, go to the episode page: https://www.dogcancer.com/podcast/ Learn more about your ad choices. Visit megaphone.fm/adchoices

About our guest:Kimberley Quirk is a lead practitioner at Mast Cell 360, blending deep clinical insight with a nurturing approach and her own lived experience through healing. She works closely with clients to map out practical, step-by-step plans that honor each person's unique pace and sensitivities.Free haywire mast cell quiz:https://mastcell360.com/mystery-quiz/MastCell360 website:https://mastcell360.com/home/ Instagram:https://www.instagram.com/mastcell360/?hl=enStephanie's links:Tiktok: https://www.tiktok.com/@drstephpeacockInstgram: https://www.instagram.com/drstephpeacock/Work with me: https://stephaniepeacock.com/ Subscribe to my newsletter: https://stephanies-newsletter-c410d1.beehiiv.com/subscribe

In this special Ask Me Anything episode of The Art of Being Well, Dr. Will Cole and his clinical team tackle your most pressing health questions - from whether food sensitivities like an avocado reaction really mean you can never eat it again, to the surprising science behind hydrogen-rich water, to what “natural flavors” actually hide (spoiler: you'll never guess one of them). They also dive into practical mast cell activation support, navigating chronic illness plateaus, the keto diet for insulin resistance, and actionable tools for calming your nervous system. Plus, learn how Dr. Cole's team uses listener voice messages in AMA episodes, and how you can submit yours for a future show. For all links mentioned in this episode, visit www.drwillcole.com/podcast.Please note that this episode may contain paid endorsements and advertisements for products and services. Individuals on the show may have a direct or indirect financial interest in products or services referred to in this episode.Sponsors:Use my link to give the new AG1 flavors a try, plus a FREE Welcome Kit: drinkag1.com/willcole. Text ABW to 64000 to get twenty percent off all IQBAR products, plus FREE shipping. Message and data rates may apply.Reverse hair loss with @iRestorelaser! Subscribe & Save for 25% off or more + free shipping on the iRestore REVIVE + Max Growth Kit, and unlock HUGE savings on the iRestore Elite with the code WILLCOLE at https://www.irestore.com/WILLCOLE!Strong Cell comes in a daily 2 oz drink, and I challenge you to take it for 30 days and see how you feel. Go to strongcell.com/will today to get started. Friends of the show get 20% off.Practice love every day with Paired, the #1 app for couples. Download the app at http://www.paired.com/beingwell.Produced by Dear Media.See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

Are your symptoms being brushed off as “just anxiety” when you know something deeper is going on? If you've been told your labs are “normal,” but your body feels anything but — you're not alone. So many people with complex, overlapping symptoms like fatigue, GI issues, dizziness, brain fog, and medication sensitivities are stuck in a loop of misdiagnosis and dismissal. And it's exhausting. In this episode of the Concussion Nerds Podcast, Dr. Zachary Spiritos — neurogastroenterologist and founder of Ever Better Medicine — pulls back the curtain on two highly misunderstood and underdiagnosed conditions: POTS (Postural Orthostatic Tachycardia Syndrome) and Mast Cell Activation Syndrome (MCAS). These aren't “rare unicorn” illnesses — they're just rarely understood.

Influencer, content creator, and founder of xHealth Studio, Jenna Gestetner, shares how she tackles sharing her personal health information while fulfilling her goal of helping others. Jenna authentically shares her life with Mast Cell Activation Syndrome (MCAS), Postural Orthostatic Tachycardia Syndrome (POTS), food allergies, and autoimmune disorders.Resources to keep you in the know:JennaXHealthInstagram: JennaXHealthTikTok: JennaXHealthYouTube: JennXHealthLinkedIn: Jenna GestetnerYou can find FAACT's Roundtable Podcast on Apple Podcasts, Pandora, Spotify, Podbay, iHeart Radio, or wherever you listen to podcasts.Follow us on Facebook, Instagram, BlueSky, Threads, LinkedIn, Pinterest, TikTok, and YouTube.Sponsored by: ARS PharmaThanks for listening! FAACT invites you to discover more exciting food allergy resources at FoodAllergyAwareness.org!

This episode was recorded at the 2025 Florida Ruminant Nutrition Symposium.  Dr. Baumgard begins with an overview of his presentation, “Importance of gut health to drive animal performance and health.” He notes the metabolic and inflammatory fingerprint of all stressors is essentially the same, indicating they likely all emanate from the gut. Overall, we're gaining a better understanding of how typical on-farm stressors negatively influence gut barrier function. He thinks the most likely mechanism of leaky gut is the immune cell known as a mast cell. When an animal or human is stressed, the enteric nervous system releases corticotropin-releasing factor, which binds to the mast cell, the mast cell degranulates, and the former contents of the mast cell (TNF-alpha, proteases, histamine, etc.) causes the gut to become leaky. (4:20)Once the GI tract barrier becomes compromised, antigens like lipopolysaccharide (LPS) can infiltrate, stimulating the immune system. Immune activation causes loss of appetite much like any other infection. The gut heals fairly quickly upon removal of the stressor(s), and the gut can also acclimate to stress such that the early stages of a stress event are more severe than later stages. Strategies to combat leaky gut remain scarce, and there is no silver bullet. There are a variety of dietary strategies to target the gut permeability issue itself. Another approach would be to bind pathogens or curb their proliferation at the membrane of the small intestine. (7:06)Dr. Neiehues asks if an antihistamine would work on gut mast cells the way it does in other body systems. Dr. Baumgard isn't sure that's ever been looked at, although there have been some studies in pigs using a product targeted to prevent mast cell degranulation. Dr. Nelson wonders if we should interfere in some of these processes because they're obviously there for a reason. Panelists discuss stress events related to parturition and transition, particularly for first-calf heifers. Dr. Baumgard notes that stacking stressors on top of one another compromises an animal's ability to tolerate stress. (9:28)We know stress can cause ulcers in humans and horses - what about ruminants? Dr. Baumgard thinks it is likely that it's happening, but we aren't looking for it. Few animals who die on-farm do receive a thorough postmortem exam. It could also be that these types of insults to the gut are not visible to the naked eye. (19:11)Dr. Nelson asks what makes some cows, despite all the challenges, able to be up and milking 150 pounds a day in no time after calving. What makes them unique? Dr. Baumgard lists some possibilities, including lower pathogenic inflammation than other cows, less tissue trauma damage to the uterus during calving, and lower sensitivity to immune activation. The panel disagrees with the notion that high-producing cows are stressed. (23:16)Dr. Niehues and Dr. Baumgard trade stories of experiments where cows maintained production even with high stress and inflammatory markers. The panel goes on to discuss subclinical infections and their impact on transition cows. Dr. Nelson notes there are retrospective datasets where cows who had metritis showed decreased feed intake even before calving. Dr. Baumgard feels that the decrease in intake has been incorrectly assumed to be the cause of the metritis. He says the decrease in intake is often around two weeks before calving and he doesn't think it's a coincidence that at the same time, the mammary gland is initiating lactogenesis. He hypothesizes the mammary gland is causing an immune response, resulting in a decrease in intake. Dr. Nelson wonders if measuring somatic cell counts of colostrum would show any differences in mammary gland inflammation during this prepartum period. (29:18)Panelists share their take-home thoughts. (42:02)Please subscribe and share with your industry friends to invite more people to join us at the Real Science Exchange virtual pub table.  If you want one of our Real Science Exchange t-shirts, screenshot your rating, review, or subscription, and email a picture to anh.marketing@balchem.com. Include your size and mailing address, and we'll mail you a shirt. 

Send us a textIt's the end of June, and I'm wrapping up our listener-powered Q&A series with a jam-packed solo episode. I tackle three big questions from Sarah, Jeanine and Wendy that span swollen fingers after COVID, mast-cell mayhem, bumps around the eyes, fertility prep, and even rheumatoid arthritis. Thanks for being here! KEY TAKEAWAYS:Swollen Fingers Post-COVID: Often linked to cellular stress, mineral imbalances (esp. low potassium), and mast cell activation. Support adrenals and mineral status first.Mast Cell & Eczema: Consider nervous system inputs (EMDR, breathwork, stress history), liver drainage, and gentle anti-inflammatory support like Holy Basil.Fertility Prep: Focus on mitochondrial support, nutrient repletion, progesterone monitoring, and nervous system regulation at least 3 months preconception.Skin Bumps Around Eyes: Often tied to liver sluggishness and drainage issues. Use face mapping as a tool; consider low-level toxin load and mineral depletion.RA vs. OA: RA = immune dysfunction; assess food reactivity (e.g., nightshades), gut health, and family toxin exposure. OA = structural; consider regenerative injections (e.g., prolozone).Family Symptom Clusters: Think environmental—evaluate for mold, radon, or metals (e.g., uranium on HTMA). Toxic burden may explain “mystery” symptoms.Rate • Review • Reach OutLove these quick-fire case breakdowns? Share the episode, leave a review on Apple Podcasts, and drop your next burning question here https://www.christabiegler.com/questions and I might answer it on air after our July 4th hiatus.See you in July, Christa

We're diving into the world of mast cell diseases, equipping you with the knowledge and tools to navigate this condition. Whether you're a patient, healthcare professional, or a caregiver, this conversation, led by Jessica Fraser, Executive Director of the Mast Cell Disease Society, will guide you on how to find resources, support, and community. Resources to keep you in the know:The Mast Cell Disease SocietyWhat Are Mast CellsEmergency Room Response Plan Find a Physician CME OpportunitiesPatient Guides and Tool Kits Support Groups You can find FAACT's Roundtable Podcast on Apple Podcasts, Pandora, Spotify, Podbay, iHeart Radio, or wherever you listen to podcasts.Follow us on Facebook, Instagram, BlueSky, Threads, LinkedIn, Pinterest, TikTok, and YouTube.Sponsored by: Blueprint MedicinesThanks for listening! FAACT invites you to discover more exciting food allergy resources at FoodAllergyAwareness.org!

Mast cell activation syndrome isn't widely recognized, but for many women, it may explain years of pain, fatigue, and hormone related chaos no one could solve.I see a lot of patients who are struggling with fatigue, pain, and hormone symptoms that don't seem to make sense on paper. And I've noticed a pattern but I wanted to talk to someone who lives in the complexity of it every day.Dr. Tania Dempsey, is one of the few physicians who's helped bring mast cell activation syndrome (MCAS) into the spotlight. Years ago, she was treating a patient who just wasn't getting better until she stumbled on a paper about mast cells that changed everything. That one article led to a phone call, a new way of thinking, and a career shifting collaboration with one of the leading voices in the field.In this conversation, we explore how MCAS shows up in gynecology especially in cases involving PCOS, perimenopause, and unexplained pelvic pain. We discuss why some patients are unusually sensitive to progesterone, how inflammation fuels insulin resistance, and what's actually going on when mast cells become overactive. We also get into the clinical triad so many of us see MCAS, hypermobility, and POTS and how they often appear together in patients who are struggling to get answers.Tania also talks about how she built her practice by spending more time listening to her patients and trusting that their symptoms meant something, even when the labs didn't show it. Highlights:What mast cells do and how they become overactive in MCAS.The overlooked link between PCOS, perimenopause, and mast cell dysfunction.Why some patients react badly to progesterone—and what to do about it.How GLP-1 drugs like Ozempic may help calm inflammation in MCAS.What to know before seeking a diagnosis or starting treatment.If this episode opened your eyes or gave you language for what you've been going through, please subscribe, leave a review, and drop a comment. I'd love to hear what resonated most with you.Dr. Dempsey's Bio:Dr. Tania Dempsey, MD, ABIHM is a world-renowned expert in complex, multisystem diseases. As founder of the AIM Center of Personalized Medicine, in Purchase, NY, Dr. Dempsey uses functional and integrative medicine to get to the patient's root cause(s) of illness and to help them find a path to optimum health. Her extensive knowledge and experience with Mast Cell Activation Syndrome, Mold, and Lyme and other Vector-Borne Diseases, has propelled her to the forefront of the medical community as a recognized and trusted speaker, researcher, advocate, and physician.Dr. Dempsey is Board-Certified in Internal Medicine and Integrative and Holistic Medicine. She received her MD degree from The Johns Hopkins University School of Medicine and her BS degree from Cornell University. She completed her Internal Medicine Residency at NYU Medical Center.She was recently elected to the Board of Directors of ILADS (International Lyme and Associated Diseases Society). She is also a member of the U.S. ME/CFS Clinician Coalition, the American Academy of Ozonotherapy, and ISSWSH (International Society for the Study of Women's Sexual Health).She is an accomplished international speaker, writer and thought leader and has 8 peer-reviewed articles in the medical literature. Her latest endeavor is cohosting the new podcast, Mast Cell Matters.Get in Touch with Dr. Dempsey:WebsiteFacebookInstagram

Join Dr. Troy on Synapse SNPS as he welcomes Mackenzie to the podcast. In this powerful episode, Mackenzie bravely shares her personal experience living with mast cell disorder. Hear firsthand about the challenges, the search for answers, and the steps she's taken on her path towards healing and reclaiming her health. If you or someone you know is navigating complex health issues, Mackenzie's story offers valuable insight and hope.

In this episode of the Spectrum of Health podcast, Dr. Christine Schaffner shares key insights from her recent presentations at leading health conferences. She explores the growing recognition of mast cell activation as a major health issue and highlights the innovative role of peptides and exosomes in treatment. Dr. Schaffner also discusses the significance of addressing cancer stem cells and the deeper root causes behind mast cell activation, offering a forward-thinking perspective on healing and clinical care. For the full show notes please visit my website: https://www.drchristineschaffner.com/Episode286  

Join Dr. Troy Spurrill and PA Richelle Voth with guest expert Bryanna Gregory, PharmD, RPh, for a focused discussion on the latest in mast cell and the Independent Medical Alliance (IMA). Explore Dr. Gregory's resources: https://www.bryanagregory.com/

An episode that explores the intricate connections between MCAS, autism, and POTS through a neurodivergent lens and the principles of functional medicine. Jess Lewis joins Matt and Angela to share her personal journey, the impact of medical gaslighting, and practical strategies for mast cell stabilization.Here's what's in store for today's episode: * In today's episode, we explore the link between MCAS and autism with special guest Jess Lewis — a functional medicine and trauma-informed neurodiversity advocate who supports individuals living with MCAS.* Jess talks about how getting COVID and being around mold kicked her mast cells into overdrive.* When our bodies are under too much stress, a dysregulated nervous system can send our mast cells into overdrive. Since autistic people are being forced to navigate a neurotypical world, we are more prone to this.* We delve into the experience of medical gaslighting and the struggle to access supportive care while living with MCAS.* Additionally, we discuss the importance of a low-histamine diet when managing MCAS and how it can play a key role in reducing symptoms.* Our hosts and Jess explore the connection between POTS and autism, and share strategies for calming and stabilizing overactive mast cells.* We then dive into the topic of anaphylaxis and how it can occur when mast cells become severely dysregulated. Jess breaks down what happens in the body during an anaphylactic response — and how, in those with MCAS, even seemingly minor triggers can lead to a cascade of symptoms when the immune system is already in a heightened state of alert.* Finally, we explore the intersection of practical and functional medicine, and how blending both approaches can offer more comprehensive support for those with complex conditions like MCAS.“When you go to the doctor, think about it like a work meeting. Have a plan, have an agenda, have the questions laid out. Use your superpowers of deep research. Bring studies - not to be combative, but just to say, ‘I wanna colaborate on this. Here's what I'm seeing, here's what I'm thinking. And if your doctor doesn't wanna listen to you, go find another doctor. Feel good about the boundaries you put in front of yourself, because you gotta advocate.” - Jess Lewis“If I can change one mind, I can change several minds… If I could change things for just a few people to have the lightbulb go off, to say, ‘I've got your back. I want to be the advocate for you. I want you to be the advocate for yourself.” - Jess LewisDid you enjoy this episode? We took a deep dive into the intersection of MCAS, autism, and neurodivergent health experiences. From medical gaslighting to the overlap with POTS and nervous system dysregulation, we unpack what it means to live in a body that's constantly on high alert. We also explore the importance of functional medicine, low-histamine diets, and practical strategies for mast cell stabilization. Join the convo with #AutisticCultureCatch!Jess Lewis (she/they) is a Chief Technology Officer, turned MCAS researcher, and founder of the Mast Cell Support community. After reversing her own severe case of MCAS triggered by COVID and mold exposure, Jess now helps others heal using an evidence-based, neurodivergent-friendly approach rooted in functional medicine and trauma-informed care. She's currently pursuing a PhD in Functional Medicine with a specialty in Mast Cell health and comorbidities, and brings a deep, systems-thinking lens to both her health advocacy and her continued leadership in tech.Show NotesThreads, Instagram, Substack: @jesslewisAdditional info and links: https://subscribepage.io/jesslewisjesslewis.comCommunity - https://community.mastcellsupport.com/invitationFood Guide Pharmacyhttps://en.wikipedia.org/wiki/QuercetinRelated Episodes:Autistic Medical Needs (Episode 14)Meat Body Maintenance (Episode 53)Autistic Medical Needs, Part 2 (Episode 108)Follow us on InstagramFind us on Apple Podcasts and SpotifyLearn more about Matt at Matt Lowry, LPPJoin Matt's Autistic Connections Facebook GroupLearn more about Angela at AngelaKingdon.com Angela's social media: Twitter and TikTokOur Autism-affirming merch shop This is a public episode. If you'd like to discuss this with other subscribers or get access to bonus episodes, visit www.autisticculturepodcast.com/subscribe

“If you have a new onset of anxiety or depression that doesn't even make sense to you, think of a more physical cause.” - Dr. Neil Nathan   Do you have issues with focus, concentration, or even finding the word you want to use? If so, you might be dealing with the hidden effects of mold toxicity and Lyme disease.  In this episode, Dr. Aimie sits down with Dr. Neil Nathan to discuss how mold toxicity and Lyme disease can create a "biology of threat" in the body that can trigger and maintain a state of hypervigilance and reactivity. This is not the only issue  mold toxins and Lyme infections can cause. They can create unique inflammatory responses that affect the brain, nervous system, and immune function, often manifesting as unexplained anxiety, depression, cognitive issues, and physical symptoms that are often misdiagnosed as mental health disorders. Dr. Nathan also introduces "the big three" factors keeping the body stuck in threat mode: limbic activation, vagal dysregulation, and mast cell activation. He'll share how these become dysregulated when faced with mold toxicity and Lyme disease, causing the body to shut down as a protective mechanism. This explains why you may experience seemingly inexplicable sensitivities and reactions despite doing all the "right" emotional and psychological work for trauma recovery. Join them as they break down the science behind the body's response to mold toxicity and Lyme disease, if it's possible to reverse it, and actionable steps you can take to start the healing journey. You'll learn more about: [05:05] How “out of the blue” anxiety, depression, or other symptoms might actually be caused by mold or Lyme [10:00] What makes the inflammation associated with these internal stressors unique [16:46]  Why the “big three” need to be addressed together in sensitive patients [17:38] How mold toxicity and Lyme can lead to chronic neurological and autoimmune conditions [20:33] The internal trauma response that can be created by mold toxicity and Lyme And more!   Dr. Neil Nathan is a Board Certified Family Physician who has been practicing medicine for over 50 years. As he studied and learned a wide variety of alternative concepts, his practice gravitated into primarily helping to diagnose and treat those patients who have not been helped by conventional medicine. He's worked with thousands of patients with complex medical illnesses such as fibromyalgia, chronic fatigue, mold toxicity, chronic Lyme disease, autism, and chronic pain.    Related Podcasts: Episode 105: How Anxiety, Depression & Trauma Reactions May Be From Mold and Heavy Metals Episode 106: How Mast Cell Activation, Histamines & Mold Toxicity Place You in a High-Risk Trauma Category   Guides, Tools & Resources: The Essential Sequence - free guide that shows you the difference between stress and trauma states of our nervous system. In just 3 steps, it walks you through what your body needs when it has stored trauma or is in a freeze response. Foundational Journey - a guided 6 week journey into your inner world with a structured sequence of somatic and parts interventions with live online classes. One of the things that happens in just the first 21 days of the Foundational Journey is that people experience a 26% decrease in daily physical pain, speaking to what Dr Schubiner was just talking about, these neural secret pains, can turn off and on, and it's not actually necessarily due to the the injury the body itself. It is a neural circuit and we're managing the pain just by working with the nervous system, looking at the habitual component of it and continuing with essential parts work.   Connect with Dr. Neil Nathan: Website   Disclaimer: By listening to this podcast, you agree not to use this podcast as medical advice to treat any medical condition in either yourself or others. Consult your own physician for any medical issues that you may be having. This entire disclaimer also applies to any guests or contributors to the podcast. Under no circumstances shall Trauma Healing Accelerated, any guests or contributors to The Biology of Trauma® podcast, or any employees, associates, or affiliates of Trauma Healing Accelerated be responsible for damages arising from the use of the podcast. Comment Etiquette: I would love to hear your thoughts on this episode! Please share your constructive feedback by using personal name or initials so that we can keep this space spam-free, and let's keep the discussion positive!  

If your body is super reactive… even the tiniest change can set off awful symptoms – then you should consider the spectrum of mast cell activation diseases.What most people find enjoyable, like healthy foods, exercise, or even sunlight, can make some feel horrible. Often these symptoms are beyond just “histamine intolerance symptoms.”And while others around you might think you're just “being dramatic” or “making a mountain out of a molehill,” it's clear to you that your body is extremely more reactive than others.It can be hard to get a clear diagnosis and help if you are struggling with mast cell activation diseases – including those with hypermobility syndrome issues like Ehlers-Danlos.If your life feels like you're constantly navigating a minefield of unexpected symptoms to the smallest things, I'm joined by Michelle Shapiro, RD, to talk about what causes you to have a “highly sensitive body.”Michelle Shapiro, RD is an Integrative/Functional Registered Dietitian in NYC who has helped over 1000+ clients reverse their anxiety, heal long-standing gut and immune issues, and approach their weight in a loving way. Michelle has a virtual private practice of 5 nutritionists where she and her team work one-on-one towards these goals. She is the host of the Quiet the Diet Podcast, where she helps listeners bridge the gap between body positivity and functional nutrition.If you've been searching for answers about your own body's unpredictable reactions or want to better understand these complex conditions, let's dive in!In This Episode:What's a “highly sensitive body” problem (that you'll be stuck with forever)?The role of mast cells as “guards” of your immune systemHistamine intolerance symptoms (and why a histamine intolerance diet doesn't help long-term)Histamine intolerance versus Mast Cell Activation DiseasesThe surprising link between MCAS, POTS, and hypermobility syndromeWhy POTS isn't a heart problemThe long COVID–histamine intolerance connectionPractical tips for managing symptoms histamine intolerance symptomsQuotes“Highly sensitive bodies often react in ways we don't expect—things that are supposed to be good for you, like healthy foods or exercise, can make you feel worse.”“Histamine issues don't just cause rashes or itchy skin; they can trigger severe insomnia, anxiety, and even psychosis.”LinksFind Michelle online | InstagramMichelle's podcast, Quiet the DietMichelle's Highly Sensitive Body Hub WaitlistHealthy Skin Show ep. 319: Mast Cell Activation Syndrome: What is MCAS + Why It's So DevastatingHealthy Skin Show ep. 166: Mold + Histamine ConnectionReady to figure out your skin's root causes so you can finally fix your skin + break free from meds to manage your skin?My virtual clinic works with adults worldwide struggling with eczema, psoriasis, rosacea, urticaria, hives, dandruff, perioral dermatitis + more.Trusted by over 1000 clients, we get results WITHOUT restrictive elimination diets.Schedule an assessment call at https://skinrepaircall.com/

Have you ever wondered why you are so reactive - to people, foods, smells, sounds and stress - while other people around you seem completely fine? Y ou are going in overdrive or even going into overwhelm, and think you just must be having a bad day or looking for what triggered you.  The answer might surprise you. A specific cell of your immune system, mast cells, could be actually causing trauma responses in your body, putting you into emotional states, that have less to do with the people around you and more with a compound those cells release, histamine.   Today we're tackling a commonly overlooked underlying reason for anxiety. We will be answering the question, How do mast cell activation and mold toxicity keep us stuck in our responses and triggers to trauma? Before we dive in, I want to dedicate this episode to the loving memory of our guest Beth O'Hara, who passed away in July 2024.  Beth was a pioneering functional naturopath who transformed countless lives through her work with Mast Cell 360, helping people understand and heal from complex cases of Mast Cell Activation Syndrome (MCAS), mold toxicity, and related conditions. She was a friend to me and I am sad to not have more time and conversations with her. In this episode, you'll discover: How to recognize if histamine is driving your anxiety  Why mold exposure can keep your body stuck in trauma responses long after exposure How mast cells bridge your immune system and emotional overwhelm Why and how mast cells will block your ability to create inner safety  Practical tools to decrease reactivity and build resilience For more information and show notes, please visit our website: https://biologyoftrauma.com/biology-of-trauma-podcast/

Are you or someone you love struggling with mysterious, multi-system symptoms—ranging from skin rashes and digestive issues to migraines and unexplained fatigue? You might have been searching for answers but keep hitting dead ends. If you've ever wondered if these diverse and seemingly unrelated symptoms could be connected, it might be time to consider Mast Cell Activation Syndrome (MCAS). MCAS is a condition that affects up to 20% of the population, yet it remains underdiagnosed and misunderstood. In today's episode, I'll be walking you through the ins and outs of MCAS, from how it's diagnosed to the practical steps you can take for treatment. If you're feeling frustrated by traditional medicine's inability to connect the dots on your health issues, this episode will provide some much-needed clarity. Let's explore how MCAS could be the missing link in your health journey and what you can do about it. Key Points: What is MCAS and Why It's Misunderstood MCAS is a multi-system inflammatory condition affecting various parts of the body, causing symptoms like skin rashes, digestive issues, and fatigue. Often misunderstood, MCAS can go undiagnosed for years as patients seek answers from multiple specialists. Dr. Dempsey's Journey to MCAS Expertise Dr. Tanya Dempsey shares her personal journey into recognizing MCAS in her patients, explaining how her curiosity and persistence led her to uncover MCAS as a common, yet often overlooked condition affecting many of her patients. How MCAS is Diagnosed: Laboratory Markers and Clinical Features Diagnosing MCAS requires looking at specific clinical features and laboratory markers. Blood and urine tests can reveal mast cell mediators, while biopsies from gastrointestinal scoping procedures can show elevated mast cells in tissue samples. This segment discusses the complexities and difficulties in obtaining a definitive diagnosis. The Role of Triggers in MCAS Identifying triggers is crucial in managing MCAS. Dr. Dempsey explains how some triggers can be environmental, while others may be internal, making them difficult to pinpoint. Understanding your specific triggers is key to effective treatment. Treatment Options for MCAS: Antihistamines and Beyond The first line of treatment often includes antihistamines—both H1 and H2 blockers. This segment covers how trial and error is often needed to find the right combination for each individual. Natural options like Vitamin C and quercetin are also explored, offering listeners alternatives to pharmaceutical interventions. Living with MCAS: Individualized Treatment Approaches One size does not fit all when it comes to managing MCAS. Dr. Dempsey highlights the importance of a personalized approach, where patients must try different treatments systematically to find what works for them. The need for patience and persistence in the journey to wellness is emphasized. Mast Cell Activation Syndrome might be the missing piece in your complex health puzzle. Whether you're dealing with unexplained chronic symptoms or feeling frustrated by a lack of answers, understanding MCAS could bring you closer to relief. The key takeaway from today's episode is that while diagnosing and treating MCAS can be challenging, it is possible—and it starts with understanding your body's unique triggers. With a combination of personalized treatments, patience, and persistence, you can regain control of your health. If any of this sounds familiar, I encourage you to explore MCAS further and, if necessary, find a practitioner knowledgeable in its diagnosis and treatment. Let's continue this journey toward better health—one piece of the puzzle at a time. How to Connect Dr. Tania Dempsey Dr. Tania Dempsey is a world renowned expert in chronic disease, autoimmune disorders, and mast cell activation syndrome, and is sought after internationally for her knowledge of chronic immune dysregulation. As founder of the AIM Center of Personalized Medicine, Dr. Dempsey uses functional and integrative medicine to get to the patient's root cause(s) of illness, understand why people get sick, help patients understand their body, and understand why it fails them when it does. She works with patients all over the United States, as well as from places around the world such as Israel, England, Thailand, and France. AIM Center for Personalized Medicine: https://drtaniadempsey.com/ How to Connect with Dr. Meg: Women's Wellness Collective: www.megmill.com/collective. use code HEALTH to get your first month 1/2 off Apply to work 1:1 with Dr. Meg: HERE Free Guide: Unraveling the Mystery: Understanding Mast Cell Activation Syndrome for simple steps and protocols you can start today to improve your gut health. You can also follow along on Instagram @drmegmill for daily health tips! Website: www.megmill.com  This content is for educational purposes only and should not be taken as medical advice. Always consult with a healthcare professional before starting any new diet or exercise program.

While high histamine levels are a very real health issue, histamines themself are not the root cause of your symptoms...     While high histamine levels may be responsible for skin rashes, digestive problems, itchiness, headaches, fatigue, brain fog, and more, true relief requires addressing the underlying imbalances causing the elevated histamines in the first place.     So join me on today's Cabral Concept 3238 as we uncover the root cause of histamine imbalances and explore actionable steps you can take to restore balance. Enjoy the episode, and I'd love to hear your feedback!   - - - For Everything Mentioned In Today's Show: StephenCabral.com/3238 - - - Get a FREE Copy of Dr. Cabral's Book: The Rain Barrel Effect - - - Join the Community & Get Your Questions Answered: CabralSupportGroup.com - - - Dr. Cabral's Most Popular At-Home Lab Tests: > Complete Minerals & Metals Test (Test for mineral imbalances & heavy metal toxicity) - - - > Complete Candida, Metabolic & Vitamins Test (Test for 75 biomarkers including yeast & bacterial gut overgrowth, as well as vitamin levels) - - - > Complete Stress, Mood & Metabolism Test (Discover your complete thyroid, adrenal, hormone, vitamin D & insulin levels) - - - > Complete Food Sensitivity Test (Find out your hidden food sensitivities) - - - > Complete Omega-3 & Inflammation Test (Discover your levels of inflammation related to your omega-6 to omega-3 levels) - - - Get Your Question Answered On An Upcoming HouseCall: StephenCabral.com/askcabral - - - Would You Take 30 Seconds To Rate & Review The Cabral Concept? The best way to help me spread our mission of true natural health is to pass on the good word, and I read and appreciate every review!  

Dr. Fiona Lovely is a longevity, health and wellness expert with specialties in menopause medicine, functional neurology and functional medicine.  She is speaking to the topics of women's health around perimenopause and menopause.   Today, Dr. Lovely welcomes Dr. Meg Mill back to the show to discuss a very contemporary health concern - mast cell activation and the role of histamine and histamine intolerance.  Whether you are a headache sufferer, have experience long haul symptoms from covid infection or shots, have questionable gut health or have mysterious symptoms that no one seems to help with, you will want to listen in.   If you are the person who feels like you have a reaction to EVERYTHING (including water), this episode is for you! Want Dr Meg's histamine guide - she references it in the show?  Please visit histamine guide here.  You can find out more about Dr Meg Mill at her website and on IG @drmegmill Thank you to our sponsors for this episode:

In this episode of the Accrescent podcast, host Leigh Ann welcomes Dr. Steph Peacock to discuss mold toxicity, its impact on health, and effective ways to heal from it. Dr. Peacock shares her journey from being a competitive swimmer to her focus on holistic medicine, particularly mold toxicity and mast cell activation syndrome. They delve into the connection between concussions and mold susceptibility, the significance of nervous system regulation, and the importance of addressing one's environment. Dr. Peacock highlights the need for proper testing and treatment, including environmental assessment, mycotoxin panels, binders, and gut motility support. The conversation also covers additional detoxification methods and the role of emotional and physical stressors on overall health.Product Discount Codes + LinksFall SkincareHerbal Face Food: The Serum IIHerbal Face Food Discount Code: LAL20Facial Lounge: Facial in a Bottle NightFacial Lounge Discount Code: LEIGHANNHoneybee Hippie: Honey Hydrate Tallow BalmHoneyBee Hippie Discount Code: LEIGHANN10Micro Balance HealthMicro Balance Health: WebsiteMicro Balance Health Code: ACCRESCENTBuoy ElectrolytesBuoy: Website (link gives 20% discount)Work w/Leigh AnnLearn: What is EVOX Therapy?Book: Schedule a Session or FREE Discovery CallMembership: What is The Uplevel Lab?Interview LinksBook Club: Now FREE, Join the Group Today!Book Club: Link if You Are NOT A Member of the Uplevel LabBook Club: Link if You ARE a Member of the Uplevel LabProduct: Ermi Dust TestProduct: Immunolytics TestLearning: Nervous System: Accrescent Podcast Episodes on the Nervous System: 147, 140, 115, 105, 104Product: Activated Charcoal: My Favorite Activated Charcoal (discount code: LEIGHANNLINDSEY)Product: Infrared Sauna:

Welcome back, Dr Rachel Venable, DVM, MS, DACVIM (oncology) to the podcast! This week we discuss mast cell tumors!I don't know about you... but I always get confused about current guidelines with MCT. They can be anything from low-grade removal and no sweat... to multiple high-grade panic! How much margin do you really need? When is Stelfonta an option? Check out all this great conversation all about MCTs and how to approach them from a boarded oncologist!TIMESTAMPSIntro 00:00Predispositions To Mast Cell Tumors 01:08Single Mast Cell Tumors 02:25Multiple Mast Cell Tumors 08:30Are Subcutaneous Mast Cell Tumors More Of A Concern? 13:54Staging Mast Cell Tumors 15:18An Overview Of Stelfonta 17:36Outro 20:10

Immune discusses two stories of immune cells eating other cells: microglia engulfing brain neurons to shape cortical development and behavior, and mast cells trapping neutrophils to increase their functional and metabolic fitness. Hosts: Vincent Racaniello, Cindy Leifer, and Brianne Barker Subscribe (free): Apple Podcasts, RSS, email Become a patron of Immune! Links for this episode MicrobeTV Discord Server Microglia shape cortical development and behavior (Cell) Neutrophil trapping by mast cells (Cell) Time stamps by Jolene. Thanks! Music by Steve Neal. Immune logo image by Blausen Medical Send your immunology questions and comments to immune@microbe.tv

Closing chapters, Diabetes, Cholesterol, Mast Cell, & Vitamin D! Your body heals itself and Janet knows how to engage all corners of that super power! Achieve full immunity and follow JANET ON IG // FOLLOW @deplorablejanet ON IG&VISIT PARANOIRADIO.COM ☂️ --- Support this podcast: https://podcasters.spotify.com/pod/show/paranoiradiopodcast/support

In this episode, Dr. Linda Bluestein, the Hypermobility MD, delves into the intricate connections between the immune system and hypermobility disorders with Dr. Kara Wada. A quadruple board-certified physician and Sjogren's patient, Dr. Wada shares her expertise on mast cell activation syndrome, autoimmunity, and the role of inflammation. Discover holistic approaches to managing these conditions and gain valuable insights into the latest research and treatments. Don't miss the special hypermobility hacks at the end! Takeaways: Interplay Between Immune System and EDS: The immune system plays a significant role in hypermobility disorders, with conditions like mast cell activation syndrome and autoimmunity frequently seen in patients with EDS. Differences in Allergy and Mast Cell Activation: Allergy involves the immune system's memory of proteins, whereas mast cell activation syndrome can be triggered by various factors, often without the presence of traditional allergies. Inflammation's Role in Chronic Conditions: Chronic inflammation is a core issue in many modern diseases, including EDS and autoimmune disorders. It's the body's prolonged response to injury or infection that can lead to various health issues. Impact of Hormones: Hormones, particularly estrogen and progesterone, significantly influence immune system functioning and can affect conditions like POTS, often seen in EDS patients. Holistic and Lifestyle Approaches: Managing EDS and related conditions can benefit from holistic approaches, including anti-inflammatory diets, regular movement, adequate sleep, and stress management techniques such as meditation and journaling. Connect with YOUR Bendy Specialist, Dr. Linda Bluestein, MD at https://www.hypermobilitymd.com/.   This episode is sponsored by EDS Guardians. If you want to learn more, check them out here: https://www.edsguardians.org/    Thank YOU so much for tuning in. We hope you found this episode informative, inspiring, useful, validating, and enjoyable. Join us on the next episode for YOUR time to level up your knowledge about hypermobility disorders and the people who have them.

Anaphylaxis, organ failure & common allergies and more! Janet supplies hope and dumps a massive load of information on how to negate this mortal disease and refill your organs, body and mind with the knowledge to combat current Mast Cell Activations. // FOLLOW @DeplorableJanet on Instagram & VISIT US AT PARANOIRADIO.COM ☂️ --- Support this podcast: https://podcasters.spotify.com/pod/show/paranoiradiopodcast/support

Text Dr. Lenz any feedback or questions Understanding Ehlers-Danlos Syndrome: Insights from Jeannie Di BonIn this episode, a special guest, Jeannie Di Bon, a movement therapist who specializes in hypermobility, Ehlers-Danlos Syndrome (EDS), and chronic pain, shares her expertise and personal journey. Diagnosed with EDS, Mast Cell Activation Syndrome, POTS, and chronic fatigue syndrome, Jeannie discusses the challenges of diagnosing these conditions, the significance of diagnosis for patients, and her development of a supportive online community and tools via the Zebra Club. She also addresses the complexities of EDS, similar conditions, and the importance of clinician awareness.00:00 Welcome to the Podcast: Introducing Jeannie Di Bon01:15 Understanding Ehlers Danlos and Hypermobility03:26 The Challenge of Diagnosis and Misdiagnosis09:59 Jeannie's Personal Journey with EDS14:13 From Chronic Pain to Movement Therapy: Jeannie's Professional Evolution22:14 Expanding Access: The Zebra Club and Online Resources24:58 Addressing Comorbidities: ADHD, Autism, and Hypermobility26:51 Final Thoughts: Hope, Support, and EducationSupport the Show.A Fibromyalgia Starter Pack, which is a great companion to the book Conquering Your Fibromyalgia, is now available. Dr. Michael Lenz practices general pediatrics and internal medicine primary care, seeing patients from infants through adults. In addition, he also will see patients with fibromyalgia and related problems and patients interested in lifestyle medicine and clinical lipidology. To learn more, go to ConquringYourFibromyalgia.com. Remember that while Dr. Lenz is a medical doctor, he is not your doctor. All of your signs and symptoms should be discussed with your own physician. He aims to weave the best of conventional medicine with lifestyle medicine to help people with chronic health conditions live their best lives possible. Dr. Lenz hopes that the podcast, book, blog, and website serve as a trusted resource and starting point on your journey of learning to live better with fibromyalgia and related illnesses.

Welcome back to our weekend Cabral HouseCall shows! This is where we answer our community's wellness, weight loss, and anti-aging questions to help people get back on track! Check out today's questions:    Lindsey: hi dr. cabral - i have had what seems to be kidney pain for years. i only get relief when my spouse does really deep tissue massages on my lower back. after, my stomach makes gurgling noises and it ends up being gas. ive gone 1 time to a gastro for this and they said it's not my kidneys but inflamed intestines appearing as kidney pain. can you please point me in the right way ?   Katherine: Hi Dr. Cabral, Thank you for all u do! You are my "benchmark" in the health world. Wondering what you would recommend a member of your family if this happened to them. Summer 2022 I had a really bad kidney stone that landed me in the hospital. I passed it. Since then I had about 4 more instances of kidney stones (but not as severe-was able to take some meds to ease the pain until it passed). Recently I went for a CT Scan and it showed my left Ureter dilated. The Urologist suggested another CT scan with dye or a to putna camera in and see if something is there causing a blockage or a tumor. Curious what I can do to be more proactive.   Tina: Love your show :) what is the best alternative to a mammogram? Thermal imaging anything you can recommend please I do not want to go for a mammogram. I've read other women with mast cell activation having breast cancer. Also, really trying hard to get rid of mast cell activation. Is cancer is a sign of mast cell activation ? Alma powder will it help mast cell activation? Alma powder better then berberine? Been researching alternatives to semaglutitde with myself having insulin resistance type 1 diabetes I am full plant based no fat no sugar no salt Please need help   Olivea: Dr. Cabral, The information you provide is wonderful. I just listened to your podcast 'why not fast until lunch' I have never been a huge proponent of fasting for myself simply because of my schedule. Curious what you would recommend for my schedule in regards to fasting and overall health - I try to eat dinner around 6:30/7pm each night. I wake up at 4:45 for the gym - I typically eat an apple on my way to the gym (I go to CrossFit) - my workout is an hour (starting at 5:15am) and then I have 1 egg + some egg whites around 7am, I then make myself a smoothie with water, fruit, and almond milk and take it to work with me and it usually takes me a few hours to drink it. I guess more of what I am asking is - someone who has morning workouts - what do you recommend for fasting?   Thank you for tuning into today's Cabral HouseCall and be sure to check back tomorrow where we answer more of our community's questions!      - - - Show Notes and Resources: StephenCabral.com/3039 - - - Get a FREE Copy of Dr. Cabral's Book: The Rain Barrel Effect - - - Join the Community & Get Your Questions Answered: CabralSupportGroup.com - - - Dr. Cabral's Most Popular At-Home Lab Tests: > Complete Minerals & Metals Test (Test for mineral imbalances & heavy metal toxicity) - - - > Complete Candida, Metabolic & Vitamins Test (Test for 75 biomarkers including yeast & bacterial gut overgrowth, as well as vitamin levels) - - - > Complete Stress, Mood & Metabolism Test (Discover your complete thyroid, adrenal, hormone, vitamin D & insulin levels) - - - > Complete Food Sensitivity Test (Find out your hidden food sensitivities) - - - > Complete Omega-3 & Inflammation Test (Discover your levels of inflammation related to your omega-6 to omega-3 levels) - - - Get Your Question Answered On An Upcoming HouseCall: StephenCabral.com/askcabral - - - Would You Take 30 Seconds To Rate & Review The Cabral Concept? The best way to help me spread our mission of true natural health is to pass on the good word, and I read and appreciate every review!  

In this episode, we sit down with Dr. Grace Liu, the founder of The Gut Institute, to delve into the intricacies of gut health and its paramount importance. She brings her extensive expertise to the table, sharing vital insights on why addressing gut health should be a top priority for overall well-being. Dr. Grace also shares top peptides to use, how to fix leaky gut, the role of different probiotics like Akkermansia, histamine intolerance, and more. Tune in to learn how you can optimize your gut health!Dr. Grace Liu PharmD is an IFM-trained functional medicine practitioner and founder of The Gut Institute. She is a clinical pharmacist with a doctorate in practice for 20+ years and specializes in complex disease management. Dr. Liu consults and helps clients gain optimal performance through rebuilding the microbiome after damage from modern living. She uses nutrigenomic tools and other advanced functional lab testing to give the solutions, strategies and treatments that reverse modern gut dysbiosis and disease. SHOW NOTES:0:51 Welcome to the show!3:55 Dr. Grace Liu's Bio4:27 Welcome her to the podcast!5:43 Why are we still overlooking gut health?7:25 About BPC-157 Peptide8:41 Optimizing the basics first10:45 Vitamin D-Gut Connection11:39 Fixing gut permeability14:58 Addressing parasite exposure16:14 Leaky Gut Procol19:34 Gut testing options23:32 Long COVID Protocols26:32 Do you have a parasite?31:18 AMPs (Peptides) & Probiotics34:53 Benefits of Akkermansia37:19 Mast Cell & Histamines40:47 Adrenal Protocols & markers of stress42:21 Benefits of warmer body temperatures46:23 Binders for supporting detox49:02 Blue Zone diets & dietary starches51:03 Oxalates, yeast & molds55:40 Stimulating oxytocin & vagal tone59:00 Getting drunk off bread1:01:16 Balancing the immune system & histamine overload1:10:42 Where to find her1:12:34 Her final piece of advice1:14:08 Thanks for tuning in!RESOURCES:The Gut Institute - Discount code: BABES10Instagram: Gut_GoddessFacebook: The Gut InstituteYouTube: Dr. Grace LiuPinterest: The Gut InstituteTikTok: Dr. Grace LiuBiOptimizers Magnesium Breakthrough - code: BIOHACKERBABES10 + subscribe to receive free gifts and additional discountsOur Sponsors:* Go to Puori.com/BIOHACKERBABES and use our promo code BIOHACKERBABES for 20% off site wide!Support this podcast at — https://redcircle.com/biohacker-babes-podcast/donationsAdvertising Inquiries: https://redcircle.com/brands

Make sure to support this podcast by heading over to Paleovalley.com/NwJ and the 15% off discount will automatically be applied to your first order. _____I'm excited to sit down with Beth O'Hara. We talk about histamines and MCAS, effects of mold in the home environment, and much more. Make sure to listen to the full interview to learn more.Beth O'Hara is a Functional Naturopathic Consultant specializing in complex, chronic cases of Mast Cell Activation Syndrome, histamine intolerance, mold toxicity, and related conditions. She is the founder and clinical director of Mast Cell 360, a functional naturopathy practice designed to address all factors surrounding health conditions – biochemical, physiological, environmental, epigenetic, and emotional wellness.Beth crafted Mast Cell 360 to resemble the practice she wished had existed when she was severely ill with Mast Cell Activation Syndrome, histamine intolerance, mold toxicity, neural inflammation, Lyme, fibromyalgia, and chronic fatigue. Her present mission is to serve as a guiding light for others navigating Mast Cell Activation Syndrome, histamine intolerance, and these related conditions in their healing journeys.We discuss the following:All about Beth O'HaraHistamines and MCASSymptoms of histamine intoleranceTesting for histamine and MCASLong COVID and MCASHow to support the nervous systemThoughts on mast cell stabilizer medicationsSensitivity to DAO supplementsMold's impact on the pancreasEffects of mold in the home environmentSupporting mold illness recoveryHealing from MCASWhere to find Beth O'Hara_____RESOURCESBeth's WebsiteBeth's FacebookHistamine Digest 360 with DAOMast Cell Nervous System Reboot Master ClassNwJ Mind-Body Program____SIGN UP FOR MY WEEKLY NEWSLETTERCHECK OUT MY BOOK, Carnivore CureCHECK OUT MY SECOND BOOK, The Complete Carnivore Diet for Beginners: Your Practical Guide to an All-Meat Lifestyle_____ ADDITIONAL RESOURCESNutrition with Judy ArticlesNutrition with Judy ResourcesNutrition with Judy Podcast_____ FIND ME