Podcasts about hypocalcemia

In this episode of The Dairy Nutrition Blackbelt Podcast, Dr. Claira Seely, from the University of New Hampshire, sheds light on the evolving understanding of subclinical hypocalcemia in dairy cattle. Dr. Seely explains how the understanding of this condition has evolved over time, especially in diagnosing it at the right moment. Learn how the timing of calcium monitoring can impact milk production, reproduction, and overall cow health. Listen now on all major platforms!"Cows with low blood calcium at four days in milk produced significantly less milk and had lower reproductive success."Meet the guest: Dr. Claira Seely is an Assistant Professor of Precision Dairy Management at the University of New Hampshire. With a PhD in Dairy Science from Cornell University, Dr. Seely's research focuses on transition cow biology and precision technology integration.Click here to read the full research articles:The association of subclinical hypocalcemia at 4 days in milk with reproductive outcomes in multiparous Holstein cowsAssociation of transient, persistent, or delayed subclinical hypocalcemia with early lactation disease, removal, and milk yield in Holstein cowsAssociation of subclinical hypocalcemia dynamics with dry matter intake, milk yield, and blood minerals during the periparturient periodWhat will you learn: (00:00) Highlight(01:21) Introduction(01:03) Guest background(02:59) Hypocalcemia insights(04:16) Diagnosis timing for hypocalcemia(05:26) Blood calcium dynamics(07:49) Reproductive and intake effects(09:05) Closing thoughtsThe Dairy Nutrition Blackbelt Podcast is trusted and supported by the innovative companies:* Adisseo- Zinpro- Volac- Afimilk- Kemin- Virtus Nutrition

When Julian was just 6 weeks old, Kady knew something wasn't right. Despite more than 16 doctors insisting Julian was fine, Kady trusted her instincts and fought for answers—refusing to leave the hospital until the right tests were done. That persistence led to a life-changing diagnosis: a rare genetic form of hypoparathyroidism. Julian's specific mutation is so unique that he is the only known case in the world. In today's episode of On Rare, David Rintell, Head of Patient Advocacy at BridgeBio, and Mandy Rohrig, Director of Patient Advocacy at BridgeBio Gene Therapy, speak with Kady, the mother of Julian, a 4-year-old boy living with ADH1. Managing his condition has been a daily balancing act, as too little calcium leads to painful, debilitating symptoms, while too much threatens his kidneys. Kady shares the emotional journey of raising a child with a rare disease, from relentless advocacy to empowering Julian with the knowledge to recognize and communicate his own symptoms.   Michael Collins, M.D., a research scientist at the National Institute of Health (NIH), provides a medical overview of Autosomal Dominant Hypocalcemia Type 1 (ADH1), a rare form of hypoparathyroidism that leads to low blood calcium levels. While most cases of hypoparathyroidism result from accidental gland removal during thyroid surgery, ADH1 is caused by genetic mutations. Often going undiagnosed until a child presents with severe symptoms, ADH1 is difficult to catch early since calcium levels are not part of routine pediatric screenings. The condition is also difficult to treat because standard calcium supplements, which alleviate ADH1 symptoms, can worsen kidney complications, increasing the risk of severe kidney stones and even renal failure. Treatment requires a delicate balance to avoid overcorrection and long-term kidney damage. Dr. Collins sheds light on the complexities of this condition and the challenges both patients and doctors face in managing it.

Dr. Hernandez recently presented a Real Science Lecture series webinar on this topic. You can find the link at balchem.com/realscience.Dr. Hernandez begins with an overview of how she came to study calcium metabolism in the mammary gland. Over the past number of years, she has worked on research to manipulate what's happening in the mammary gland in the prepartum period to ensure adequate endocrine, nutritional, reproductive, and immunological status. (5:55)The panelists discuss how “normal” has changed when it comes to transition cow health. Dr. Overton reminds listeners that 25 years ago, 6-8% of fresh cows in a herd having clinical milk fever was pretty typical. Now, we accept none of that. Subclinical hypocalcemia was not on the radar then, and we thought we had calcium all figured out. Dr. Hernandez's work shows that this was not the case. She is pleased that a synergism of producers, veterinarians, and academics have been working together to understand the mechanisms of calcium metabolism to find solutions for individual farms based on their situation. (9:22)Dr. Hernandez then discusses various interventions used in the industry, including low-potassium diets, negative DCAD diets, and zeolite clays. The clays are new to the US, and it seems that they work primarily through a phosphorus reduction mechanism and are best limited to feeding 10-14 days pre-calving. (18:14)Dr. Overton asks Dr. Hernandez about a point in her webinar that cows are in negative calcium balance through 150-200 days in milk. She confirms that there are approximately 8.5 kilograms of calcium in the bones of a cow, but we don't know how much of that she loses each lactation. Her dream scenario would be a CT scanner large enough to fit a dairy cow in to evaluate how her bones change throughout lactation. This leads to a discussion of whether or not we should be including higher rates of calcium in dairy cow diets. Dr. Hernandez would like to learn more about what's happening with calcium absorption in the gut in real-time with endocrine status and stage of lactation, which is a challenging task. (23:17)Co-host, Dr. Jeff Elliott, asks if the reason multiparous cows are more prone to milk fever is because they're not as efficient at calcium resorption to the bone. Dr. Hernandez doesn't have a definitive answer, but it could be due to less effective gut absorption with age, or it may be related to the influence of estrogen on bone density. She also mentions it could be endocrine-controlled or even stem cell-related.  (28:59)Dr. Hernandez's hypothesis has always been that you have to have a calcium decrease to trigger the negative feedback loop involved in calcium metabolism. Her advice is to wait until 48 hours to take a blood sample to analyze calcium. This aligns well with epidemiological research on the veterinarian side regarding delayed, persistent, transient, and normal hypocalcemic animals. (33:04)Dr. Overton asks about a calcium-chelation study that Dr. Hernandez's group conducted and whether or not chelating calcium had an impact on colostrum production. It did not in that experiment. Dr. Hernandez was surprised at how much chelating agent was needed to overcome the draw of the mammary gland, but that further underlines how much of a priority lactation is in metabolism. (41:45)Scott asks both panelists their views on what the priority should be for research in this area. Dr. Hernandez's ideas include more research on how zeolite clays work biologically, finding out what's happening in the gut, mammary gland, and bone of a dairy cow at different stages of lactation. She emphasizes that research should be conducted at different stages rather than just extrapolating from one stage to another because lactation is incredibly dynamic. Dr. Overton seconded the idea of a better understanding of zeolite clays and their feeding recommendations, as well as research defining what happens to and where all the calcium is pulled from the bone during lactation. (45:32) In closing, Jeff, Tom, and Laura share their take-home thoughts. Jeff is excited to learn more about how zeolite clays work and if other products may come to the forefront to help in calcium metabolism management. Tom commends Laura on her work and how it has dovetailed so well with the epidemiological research from the veterinary side. Laura reminds listeners that the mammary gland is running the show and is thrilled that her work as a basic scientist is having an applied impact on the dairy industry. (51:17)Please subscribe and share with your industry friends to invite more people to join us at the Real Science Exchange virtual pub table.  If you want one of our Real Science Exchange t-shirts, screenshot your rating, review, or subscription, and email a picture to anh.marketing@balchem.com. Include your size and mailing address, and we'll mail you a shirt.

In this episode of The Dairy Podcast Show, Dr. Miguel Morales from Protekta shares innovative strategies for managing hypocalcemia in transition cows, focusing on the critical roles of calcium and phosphorus metabolism during the transition period. Dr. Morales introduces a new approach that bypasses traditional acidification methods, discussing its impact on dairy health, productivity, and operational efficiency. Listen now on all major podcast platforms!"Instead of traditional acidification, we're using a method to control hypocalcemia in dairy cows focusing on calcium balance."Meet the guest: Dr. Miguel Morales, a veterinary graduate from the Universidad Nacional Autónoma de México, serves as a Technical Service-Dairy at Protekta, focusing on the dairy industry in the Western District. With over 35 years of experience across the United States and Latin America, he specializes in technology adoption, workforce management, and sustainable practices.What you'll learn:(00:00) Highlight(01:13) Introduction(03:46) Hypocalcemia in dairy cows(06:15) Calcium-phosphorus balance(12:13) Diet formulation tips(16:23) Minimum feeding duration(17:28) Feed intake considerations(22:20) Final three questionsThe Dairy Podcast Show is trusted and supported by innovative companies like: Protekta* Adisseo- Volac- SmaXtec- Acepsis- Berg + Schmidt- Trouw Nutrition- Natural Biologics- Scoular- ICC- Priority IAC- dsm-firmenich- Diamond V

Nutritionists are often blamed for transition cow problems like high NEFAs, clinical and subclinical ketosis, and subclinical hypocalcemia. Dr. Baumgard suggests these symptoms are a result of one of two situations: 1. These are highly productive, healthy, and profitable cows; or 2. The symptoms are the metabolic reflection of immune activation, likely stemming from metritis, mastitis, pneumonia, or GI tract inflammation. In the first scenario, the nutritionist deserves a raise; in the second, these are mostly management issues not caused by nutrition. (1:26) If listeners are interested in more detail on this topic, Dr. Baumgard suggests reading this 2021 review in the Journal of Dairy Science: “ Invited review: The influence of immune activation on transition cow health and performance—A critical evaluation of traditional dogmas.” Link: https://www.sciencedirect.com/science/article/pii/S0022030221006329Dr. Baumgard highlights key concepts that underpin his thinking regarding transition cows: The best indicators of health are feed intake and milk yield, it's too easy to overthink the immune system, Mother Nature is rarely wrong, and inconsistent or non-reproducible data should create doubt. He goes on to review the incidence of metabolic disorders in early lactation and the energy balance dynamics of the transition period. (4:29)For decades, we've had the assumption that NEFAs and ketones are causing many of the health issues in transition cows. NEFAs, BHBs, and calcium have been correlated and associated with negative outcomes. However many other studies do not find these negative correlations or associations. Plasma NEFA is markedly increased following calving in almost all cows, yet only 15-20% get clinical ketosis. Dr. Baumgard suggests that it's presumptuous and reductionist of us to assume we can use one metabolite to diagnose the disease. Little mechanistic evidence exists to explain how these symptoms cause metabolic disease issues.  (10:29)If hyperketonemia, high NEFA, and subclinical hypocalcemia are causing disease, then therapeutically treating these disorders would improve overall cow health. NAHMS data does not back that up. Dr. Baumgard dissects the dogma of ketosis. In short, mobilization of adipose tissues and partial conversion of NEFA to ketones is essential for maximum milk yield. (18:35)High-producing cows are more hypoinsulinemic compared to low-producing cows, and transition period insulin concentrations are inversely related to whole lactation performance. Low insulin concentrations coupled with insulin resistance allow for fat mobilization. (29:02)Post-calving inflammation occurs in all cows. Sources include the mammary gland, the uterus,  and the gut. Severe inflammation precedes the clinical presentation of the disease. In one experiment, all cows exhibited some inflammation in very early lactation. However, cows that were culled or died before 100 days in milk were already severely inflamed during the first few days of lactation. Dr. Baumgard thinks inflammation is the simplest and most logical explanation for why some cows don't eat well before and after calving.  (31:13)While clinical hypocalcemia (milk fever) is pathological and requires immediate intervention, is subclinical hypocalcemia detrimental to health, productivity, and profitability? (36:33)Dr. Baumgard's paradigm-shifting concept suggests that increased NEFA and hyperketonemia are caused by immune activation-induced hypophagia, and hypocalcemia is a consequence of immune activation. He goes on to use a high-producing, a low-producing, and a sick cow to illustrate this concept. (43:26)In summary, the metabolic adjustments in minerals and energy during the transition period are not dysfunctional and don't need to be “fixed.” The real fix is to prevent immune activation in the first place to prevent the cow from going off feed. Profitable production is a consequence of wellness. (52:19)Dr. Baumgard takes a series of engaging questions from the webinar audience. Watch the full webinar at balchem.com/realscience. (56:04)Please subscribe and share with your industry friends to invite more people to join us at the Real Science Exchange virtual pub table.  If you want one of our Real Science Exchange t-shirts, screenshot your rating, review, or subscription, and email a picture to anh.marketing@balchem.com. Include your size and mailing address, and we'll mail you a shirt.

*The new agreement between the U.S. and Mexico should make it easier for Mexico to pay its water debt to the Rio Grande Valley.  *The demand for silage sorghum in increasing in the Texas High Plains.  *Washington lawmakers have selected a new leader in the Senate.  *There are some important contacts to make after you purchase rural property.  *From natural disasters to high input costs and low prices for certain commodities, farmers and ranchers are seeing a lot of red on their financial ledgers. *Hypocalcemia can be a serious issue in dairy cows.   

In this episode of the PFC Podcast, Dennis speaks with Dr. Lee Cancio, a surgeon and director of the U.S. Army Institute of Surgical Research Burn Center. They discuss the complexities of managing white phosphorus burns, a serious concern in modern warfare. Dr. Cancio shares insights on the properties of white phosphorus, the mechanisms of injury, and the critical steps in initial care and management of such injuries. The conversation also covers the importance of fluid resuscitation, monitoring for complications like hypocalcemia, and the role of surgical interventions in treating burn patients. Dr. Cancio emphasizes the need for urgent care and the challenges faced in prolonged field care scenarios. Takeaways Dr. Cancio has extensive experience in treating burn injuries from combat. White phosphorus burns can cause both thermal and chemical injuries. Immediate immersion in water is crucial for managing phosphorus burns. Hypocalcemia is a significant risk in patients with phosphorus injuries. Surgical debridement is often necessary for effective treatment. Fluid resuscitation is essential, especially for deeper burns. Monitoring heart rate and EKG is critical for detecting complications. Whole blood can be used in burn shock if no other options are available. Ongoing assessment of wounds is necessary to prevent re-ignition. The relationship between burn size and mortality can be atypical in phosphorus injuries. Thank you to Delta Development Team for in part, sponsoring this podcast. ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠deltadevteam.com⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ For more content go to ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠www.prolongedfieldcare.org⁠⁠⁠⁠⁠⁠ ⁠⁠⁠⁠ Consider supporting us: ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠patreon.com/ProlongedFieldCareCollective⁠⁠⁠⁠⁠⁠ or ⁠⁠⁠⁠⁠⁠www.lobocoffeeco.com/product-page/prolonged-field-care⁠

This episode of the Real Science Exchange podcast was recorded during a webinar from Balchem's Real Science Lecture Series.Dr. Goff sees three main challenges for transition cows: negative energy and protein balance, immune suppression, and hypocalcemia. About half of all older cows experience hypocalcemia, and around 3% will experience milk fever. Cows develop hypocalcemia if they are unable to replace the calcium lost in milk from either their bone or diet. Compared to the day before calving, a cow needs around 32 extra grams of protein the day of calving to meet her increased requirements. (2:00)Dr. Goff reviews the pathways of calcium homeostasis and the actions of parathyroid hormone (PTH). Aged cows may have a harder time maintaining calcium homeostasis due to the loss of vitamin D receptors in the intestine with age and fewer sites of active bone resorption capable of responding quickly to PTH once they have finished growing. Blood pH plays a role in calcium homeostasis: when blood pH becomes alkaline, animals become less responsive to PTH. Dr. Goff reviews the impacts of high vs low DCAD diets and reviews the amount of time it takes for the kidney and bone to respond to PTH. (4:20)There are several strategies to reduce the risk of hypocalcemia. One is to reduce dietary potassium so the cow is not as alkaline. Using forages from fields that have not had manure applied to them is one way to accomplish this. In addition, warm-season grasses (corn) accumulate less potassium than cool-season grasses, and all grasses contain less potassium as they mature (straw). A second strategy is to add anions such as chloride or sulfate to the diet to acidify the blood to improve bone and kidney response to  PTH. Research has shown that sulfate salts acidify about 60% as well as chloride salts. The palatability of anionic diets has led to commercial products such as Soychlor. (13:06)Dr. Goff then discusses the over- and under-acidification of diets and gives his opinion on the appropriate range of urine pH for proper DCAD diet management, including a new proposed DCAD equation to account for alkalizing and acidifying components of the diet. He also gives some options for pH test strips to use for urine pH data collection. (18:30)Dr. Goff's lab has found that as prepartum urine pH increases, the calcium nadir decreases. The inflection point is right around pH 7.5, where above 7.5 indicates a higher risk of hypocalcemia. Data from other researchers suggests that urine pH lower than 6.0 may result in lower blood calcium, indicating an overall curvilinear response. Low urine pH (under 6.0) has also been associated with a higher incidence of left-displaced abomasum. (29:02)Moving on to other minerals, Dr. Goff discusses phosphate homeostasis and how that interacts with calcium in the close-up cow. Feeding too much phosphorus can decrease calcium absorption and feeding low phosphorus diets before calving can improve blood levels of calcium. He recommends less than 0.35% phosphorus in close-up cow diets. For magnesium,he recommends 0.4% prepartum and immediately postpartum to take advantage of passive absorption across the rumen wall. (31:08)Another strategy to reduce milk fever risk is to reduce dietary calcium prior to calving to stimulate parathyroid hormone release well before calving. A zeolite product that binds calcium is now available and may make this much easier to achieve. (42:59)In closing, Dr. Goff reminds the audience that some level of hypocalcemia post-calving is normal and in fact, is associated with higher milk production. The key is making sure that the cow's blood calcium levels can bounce back to normal by day two after calving. (51:23)Please subscribe and share with your industry friends to invite more people to join us at the Real Science Exchange virtual pub table.  If you want one of our Real Science Exchange t-shirts, screenshot your rating, review, or subscription, and email a picture to anh.marketing@balchem.com. Include your size and mailing address, and we'll mail you a shirt.

Welcome to the emDOCs.net podcast! Join us as we review our high-yield posts from our website emDOCs.net. Today on the emDOCs cast with Brit Long, MD (@long_brit), we look at hypocalcemia in trauma and the diamond of death. To continue to make this a worthwhile podcast for you to listen to, we appreciate any feedback and comments you may have for us. Please let us know!Subscribe to the podcast on one of the many platforms below:Apple iTunesSpotifyGoogle Play

Ricky and Justin discuss their research on the administration of calcium in hemorrhagic shock. They explain how they became interested in the topic and the gaps they identified in current medical knowledge. They discuss the importance of calcium in the clotting cascade and the potential role of citrate in contributing to hypocalcemia. They also explain the protocol for administering calcium in the field and the different forms of calcium that can be used. They discuss the risks of overcorrection of hypocalcemia and the need for further research on the topic. Overall, their research aims to improve patient outcomes and reduce mortality in hemorrhagic shock. Takeaways Calcium plays a crucial role in the clotting cascade and may be important in the treatment of hemorrhagic shock. Hypocalcemia is common in trauma patients and may contribute to increased mortality. The administration of calcium, along with blood products, can help prevent hypocalcemia and improve patient outcomes. The protocol for administering calcium in the field includes giving one gram upfront and one gram every four units of threshold blood. There is a risk of overcorrection of hypocalcemia, which can lead to hypercalcemia and increased mortality. Further research is needed to determine the optimal timing and dosage of calcium administration in hemorrhagic shock. Thank you to Delta Development Team for in part, sponsoring this podcast. ⁠⁠⁠⁠⁠⁠deltadevteam.com⁠⁠⁠⁠⁠⁠ For more content go to ⁠⁠⁠⁠⁠⁠www.prolongedfieldcare.org⁠⁠ ⁠⁠⁠⁠ Consider supporting us: ⁠⁠⁠⁠⁠⁠patreon.com/ProlongedFieldCareCollective⁠⁠ or ⁠⁠www.lobocoffeeco.com/product-page/prolonged-field-care

HOST: Andy Herber, P.A.-C. GUEST: Mira T. Keddis, M.D. Join our host, Andy J. Herber, P.A.-C. to take a deeper look at hypercalcemia and hypocalcemia. This podcast will do a review of the management of calcium disorders with guest,  Mira T. Keddis, M.D. Mayo Clinic Talks: Lab Medicine Edition | Mayo Clinic School of Continuous Professional Development Connect with the Mayo Clinic's School of Continuous Professional Development online at https://ce.mayo.edu/ or on Twitter @MayoMedEd.

Neonates Deep Dive: Caring for the Dam and Hypocalcemia Dr. Marty Greer, DVM joins host Laura Reeves for a continuation of their ongoing conversation about neonates. The discussion today includes hypocalcemia and eclampsia, how much calcium to supplement and when. “For some bitches, you need to continue (calcium supplementation) until the puppies are weaned,” Greer said. “It depends on the size of the bitch and the size of the litter. The smaller the bitch and the bigger the litter, the more you need calcium. It tends to be... in small breed bitches that develop hypocalcemia, eclampsia, that that tends to be an issue. “We don't see it in Labs, Goldens, Rottweilers, you know, the big dogs, but in the little dogs, and you know, I mean little dogs usually under 10 or 15 pounds, dachshunds, terriers, some of those small breeds, we can see hypocalcemia. In those cases the bitch will start to run a low grade fever. The first symptoms are going to be that she starts walking kind of goose-stepping like real stiffly, associated with the calcium becoming too low and then her muscles developing this tetany. “When the puppies are growing at about that two to three week time period, when the puppies are really growing fast, is when the demands of the calcium become the greatest on those small breed bitches and they just don't have the ability to mobilize enough calcium from their bones, their vitamin D levels are trying, but they just don't have the ability to mobilize calcium quickly enough. “And this is why you don't want to give calcium prior to the time that the bitch goes into labor and has her puppies. If you give it during the entire pregnancy, then you tell her parathyroid gland, "You know what, you can just take a vacation. "You don't have to worry about this, just hang out." And then their calcium doesn't mobilize adequately. “So you want them on a normal amount of calcium in their regular dog food, and then once they whelp, then that's when you can start adding the additional calcium in gel form, in tablet form, in powder form to the diet along with the puppy food to make sure she gets adequate amounts of calcium. “The powder, the gel, those are all going to be fine and safe because the GI tract is going to only absorb and the body's only going to take in so much. So you're okay to be pretty aggressive. Now there's definitely some things that you have to be concerned about if you're giving (calcium) by injection. But if you're giving oral in the powder or the tablet form, you know the petcal or the revival or the whatever product you want to use, those are all absolutely fine to give. You have to really screw up to give too much. But it does make a big difference and you basically titrate it until you see the effect that you're looking for. Greer touches on a variety of different topics in this wide-ranging conversation, so check out the entire podcast here.

In the latest episode of The Dairy Nutrition Blackbelt Podcast, we approach the pivotal role of phosphorus in the nutrition management of dairy herds, a critical aspect often overlooked in mitigating hypocalcemia. Our guest, Rod Martin, comes back and brings to light the impact of dietary phosphorus levels on dairy cows' blood calcium levels, emphasizing the necessity of carefully balanced diets. This episode is a treasure trove of knowledge for both seasoned and aspiring nutritionists in the dairy industry, offering insights into effective diet formulation and management strategies. Tune in on all major platforms to uncover essential dietary considerations for optimal herd health.Meet the guest: Join us as we welcome Rod Martin back, a distinguished nutritionist from Protekta, on The Dairy Nutrition Blackbelt Podcast. With years of expertise, Rod shares invaluable insights on managing hypocalcemia in dairy cows through strategic nutrition, emphasizing the critical role of phosphorus. His knowledge provides a foundation for effective dairy herd management strategies. Don't miss his practical advice by tuning into the episode on all major platforms.The Dairy Nutrition Blackbelt Podcast is trusted and supported by the innovative company:* Adisseo

Listen to FDA Drug Safety Podcast titled, FDA adds Boxed Warning for increased risk of severe hypocalcemia in patients with advanced chronic kidney disease taking osteoporosis medicine Prolia (denosumab).

T-cell malignancies prompt label changes for certain T-cell immunotherapies; Novel opioid provides in-built protection against overdose; Hypocalcemia risk with Prolia; At-Home semen insemination kit cleared; New asthma rescued medicine approved

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Join Yvonne Brandenburg, RVT, VTS SAIM and Jordan Porter RVT, VTS SAIM as we talk about: The finicky mineral named calcium. Too much can cause issues, too little cause issues. It is a picky thing. This week though we are diving into the fine details of what happens when there is low levels of calcium in the body.     Resources We Mentioned in the Show  Merck Veterinary Manual:  https://www.merckvetmanual.com/metabolic-disorders/disorders-of-calcium-metabolism/hypocalcemia-in-small-animals VIN:  https://veterinarypartner.vin.com/default.aspx?pid=19239&id=4952400 PubMed:  https://pubmed.ncbi.nlm.nih.gov/24144092/   Thanks so much for tuning in. Join us again next week for another episode!  Want to earn some RACE approved CE credits for listening to the podcast? You can earn between 0.5-1.0  hour of RACE approved CE credit for each podcast episode you listen to.    To sign up for the IMFVT Fall Conference of 2023, use this link: https://imfpp.org/conference23   Sunday November 12th 7am/10am-4:30pm/7:30pm PST/EST $49 for members $159 for non members   Join the Internal Medicine For Vet Techs Membership to earn and keep track of your continuing education hours as you get your learn on!   Join now! http://internalmedicineforvettechsmembership.com/   Get Access to the Membership Site for your RACE approved CE certificates Sign up at https://internalmedicineforvettechsmembership.com  Get Access to the Technician Treasure Trove  Sign up at https://imfpp.org/treasuretrove    Thanks for listening!  – Yvonne and Jordan   

On this month's EM Quick Hits podcast: Anand Swaminathan on the role of methylene blue in septic shock, Nour Khatib on jaw dislocation reduction techniques, Hans Rosenberg on a phenotypic approach to Crohn's disease emergencies, Gil Yehudaiff on evidence based analgesics in renal colic, Brit Long on the importance of inhaled steroids for asthma, and Andrew Petrosoniak on the "lethal diamond" in polytrauma patients and the current state of hypocalcemia in bleeding trauma patients... The post EM Quick Hits 51 – Methylene Blue in Septic Shock, TMJ Dislocation, Crohn's Disease, Analgesia for Renal Colic, Inhaled Steroids for Asthma, Hypocalcemia in Bleeding Trauma Patients appeared first on Emergency Medicine Cases.

Guests:  Dr. Gonzalo Ferreira from Virginia Tech and Dr. Bill Weiss from The Ohio State UniversityA Journal Club podcast is a staff and fan favorite, and joining us for today's Journal Club is Dr. Gonzalo Ferreira from Virginia Tech and Dr. Bill Weiss from The Ohio State University. Dr. Ferreira will be discussing his paper about including alfalfa in multigravida Holsteins. Dr. Ferreira starts with an overview of his research and said that he did a preliminary trial in Virginia Tech and saw that the urine pH was being decreased by using a product called polyhalite. (5:36) Dr. Weiss pointed out that the study had a fair number of clinical hypocalcemia, about 10-15%, which is high. (27:39) Dr. Ferreira said that in testing the polyhalite, he included between 400-500 grams per cup per day. And everything was going well in the case of Calcium Chloride; it is stronger, so you can add less and have the same acidification process. (37:03) Dr. Ferreira wrapped up by encouraging people doing research not to get stuck in a theory. Sometimes you need to get out of the box and try different things. (48:45) You can find Dr. Ferreira's paper here: https://www.journalofdairyscience.org/article/S0022-0302(23)00170-4/fulltextPlease subscribe and share with your industry friends to bring more people to join us around the Real Science Exchange virtual pub table.  If you want one of our new Real Science Exchange t-shirts, screenshot your rating, review, or subscription, and email a picture to anh.marketing@balchem.com. Include your size and mailing address, and we'll get a shirt in the mail to you.

Vitamin D3 is a Fat-soluble vitamin that helps your body absorb calcium and phosphorus. Vitamin D, calcium, and phosphorus are important for building and keeping strong bones. Vitamin D prevents and treats bone disorders ( rickets, osteomalacia, osteoporosis ). It is made by the body when the skin is exposed to sunlight. It is also used with other medications to treat Hypocalcemia caused by certain disorders such as ( hypoparathyroidism and pseudohypoparathyroidism). Vitamin D drops are given to infants because breast milk usually has low Vitamin D levels.OsteomalaciaIt is a condition that affects bone development in children & causes bone pain, poor growth, and soft; it is called rickets.Osteoporosis:Is when your bone mineral density and bone mass decrease or when the quality or structure of the bone changes.How does vitamin D3 work?Vitamin D3 can enhance the absorption of calcium in the intestine. If the body doesn't have enough vitamin D3 to absorb calcium, the body will remove calcium from the bones. This makes bones fragile and increases the risk of osteoporosis.Vitamin D3 supplementation can protect your body from acute respiratory infections and pneumonia.Vitamin D3 supplementation can lower blood pressure and protect from stroke and heart attack.Vitamin D3 supplementation can protect women's bodies from weight loss in postmenopausal women.Read more here

Question-based Review on Differential Diagnosis of Hypercalcemia (Pseudohypercalcemia, PTH-dependent vs PTH-independent Hypercalcemia) and Hypocalcemia; Vitamin D abnormalities, Abnormalities of Phosphate. Also discussed: Workup & Management of Humoral Hypercalcemia of Malignancy, Familial Hypocalciuric Hypercalcemia, Pseudohypoparathyroidism, True Hypoparathyroidism, Primary, 2ndary and tertiary hyperparathyroidism, Medications Side-Effects causing abnormalities of Ca & P.

Guests: Dr. Lance Baumgard, Iowa State University and Dr. Jim Drackley, University of Illinois at Urbana-ChampaignOur Real Science Exchange pubcast always has leading scientists and industry professionals discussing the latest ideas and trends, and tonight we have two very well-known guests. Dr. Lance Baumgard and Dr. Jim Drackley join us to discuss cow management and the dogma that has developed over the years. Dr. Baumgard kicks off by explaining the dogma of the transition period - two metabolites reduce the animal's immune system and predispose them to health disorders. (5:38) Dr. Drackley continued by saying he was influenced by research that could show in a clinical case of ketosis, there is an underlying subclinical, perhaps inflammatory pressure, causing the problem. (20:39) Dr. Baumgard mentioned utilizing ketones comes at a metabolic disadvantage: a loss of energy. So what could cows be doing if they're able to increase their feed intake enough so they don't have to make ketones? (27:18) Dr. Drackley said the million-dollar question is if inflammation is the key, what do we do about it? How do we prevent it or treat it? (31:38) Dr. Baumgard explained his thought process is that if even healthy cows have some level of immune activation going on in the transition period, some of this subclinical hypocalcemia that's occurring in the transition period could be caused by immune activation. (43:50)Dr. Drackley said as we select for high-milk production, perhaps part of that is enhanced ability to use ketones. The idea of a tenant of high milk production is you've got the time of lower insulin and high growth hormone driving lactation. Those are all tied up with genetic selection.  (46:40) Dr. Baumgard wrapped up by saying from a producer or veterinarian perspective, it's easy to treat and get out, but what really needs to take place is a full examination; where did this immune activation come from? (54:56)Please subscribe and share with your industry friends to bring more people to join us around the Real Science Exchange virtual pub table.  If you want one of our new Real Science Exchange t-shirts, screenshot your rating, review, or subscription, and email a picture to anh.marketing@balchem.com. Include your size and mailing address, and we'll get a shirt in the mail to you.

This podcast explores the clinical features of hypocalcemia as well as etiologies, investigations and initial management plan. It was developed by Dr. Madeline Parker a pediatrics resident at the University of Saskatchewan and Dr. Munier Nour a pediatric endocrinologist at Jim Patterson Children's Hospital in Saskatoon, Saskatchewan

Calcium administration to trauma patients has become a hot topic with the rise of the “Lethal Diamond."  While evidence exists regarding the association between hypocalcemia and mortality, it remains unclear whether hypocalcemia is the problem or simply a finding secondary to critical injury.  In this podcast, Dr. Lauria reviews the evidence behind calcium administration in trauma and identifies which patients, given the available evidence, might benefit from calcium administration. Don't miss another FlightBridgeED Podcast feature episode of the MDCast! So much good stuff! Please like, subscribe, and leave any questions or comments. References for the use of Calcium in Severe Trauma Chanthima P, Yuwapattanawong K, Thamjamrassri T, et al. Association Between Ionized Calcium Concentrations During Hemostatic Transfusion and Calcium Treatment With Mortality in Major Trauma. Anesth Analg. Jun 1 2021;132(6):1684-1691. doi:10.1213/ANE.0000000000005431 D B. Prehospital administration of calcium in trauma J Paramed Prac. 2022; DeBot M, Sauaia A, Schaid T, Moore EE. Trauma-induced hypocalcemia. Transfusion. Aug 2022;62 Suppl 1:S274-S280. doi:10.1111/trf.16959 Ditzel RM, Jr., Anderson JL, Eisenhart WJ, et al. A review of transfusion- and trauma-induced hypocalcemia: Is it time to change the lethal triad to the lethal diamond? J Trauma Acute Care Surg. Mar 2020;88(3):434-439. doi:10.1097/TA.0000000000002570 Giancarelli A, Birrer KL, Alban RF, Hobbs BP, Liu-DeRyke X. Hypocalcemia in trauma patients receiving massive transfusion. J Surg Res. May 1 2016;202(1):182-7. doi:10.1016/j.jss.2015.12.036 Kronstedt S, Roberts N, Ditzel R, et al. Hypocalcemia as a predictor of mortality and transfusion. A scoping review of hypocalcemia in trauma and hemostatic resuscitation. Transfusion. Aug 2022;62 Suppl 1(Suppl 1):S158-S166. doi:10.1111/trf.16965 Leech C, Clarke E. Pre-hospital blood products and calcium replacement protocols in UK critical care services: A survey of current practice. Resusc Plus. Sep 2022;11:100282. doi:10.1016/j.resplu.2022.100282 Messias Hirano Padrao E, Bustos B, Mahesh A, et al. Calcium use during cardiac arrest: A systematic review. Resusc Plus. Dec 2022;12:100315. doi:10.1016/j.resplu.2022.100315 Moore HB, Tessmer MT, Moore EE, et al. Forgot calcium? Admission ionized-calcium in two civilian randomized controlled trials of prehospital plasma for traumatic hemorrhagic shock. J Trauma Acute Care Surg. May 2020;88(5):588-596. doi:10.1097/TA.0000000000002614 Savioli G, Ceresa IF, Caneva L, Gerosa S, Ricevuti G. Trauma-Induced Coagulopathy: Overview of an Emerging Medical Problem from Pathophysiology to Outcomes. Medicines (Basel). Mar 24 2021;8(4)doi:10.3390/medicines8040016 Steele T, Kolamunnage-Dona R, Downey C, Toh CH, Welters I. Assessment and clinical course of hypocalcemia in critical illness. Crit Care. Jun 4 2013;17(3):R106. doi:10.1186/cc12756 Stueven H, Thompson BM, Aprahamian C, Darin JC. Use of calcium in prehospital cardiac arrest. Ann Emerg Med. Mar 1983;12(3):136-9. doi:10.1016/s0196-0644(83)80551-4 Vallentin MF, Granfeldt A, Meilandt C, et al. Effect of Intravenous or Intraosseous Calcium vs Saline on Return of Spontaneous Circulation in Adults With Out-of-Hospital Cardiac Arrest: A Randomized Clinical Trial. JAMA. Dec 14 2021;326(22):2268-2276. doi:10.1001/jama.2021.20929 Vallentin MF, Povlsen AL, Granfeldt A, Terkelsen CJ, Andersen LW. Effect of calcium in patients with pulseless electrical activity and electrocardiographic characteristics potentially associated with hyperkalemia and ischemia-sub-study of the Calcium for Out-of-hospital Cardiac Arrest (COCA) trial. Resuscitation. Dec 2022;181:150-157. doi:10.1016/j.resuscitation.2022.11.006 Vasudeva M, Mathew JK, Groombridge C, et al. Hypocalcemia in trauma patients: A systematic review. J Trauma Acute Care Surg. Feb 1 2021;90(2):396-402. doi:10.1097/TA.0000000000003027 Vettorello M, Altomare M, Spota A, et al. Early Hypocalcemia in Severe Trauma: An Independent Risk Factor for Coagulopathy and Massive Transfusion. J Pers Med. Dec 28 2022;13(1)doi:10.3390/jpm13010063 Wray JP, Bridwell RE, Schauer SG, et al. The diamond of death: Hypocalcemia in trauma and resuscitation. Am J Emerg Med. Mar 2021;41:104-109. doi:10.1016/j.ajem.2020.12.065 Zhang Z, Xu X, Ni H, Deng H. Predictive value of ionized calcium in critically ill patients: an analysis of a large clinical database MIMIC II. PLoS One. 2014;9(4):e95204. doi:10.1371/journal.pone.0095204 See omnystudio.com/listener for privacy information.

This episode reviews a shift from the "lethal triad" in trauma to the "diamond of death," exploring the role of calcium in hemostasis and critically ill patients. We review the literature that is available on hypocalcemia and trauma patients References/show notes: FOAMcast.org Thanks for listening! Lauren Westafer

FDA investigating risk of severe hypocalcemia in patients on dialysis receiving osteoporosis medicine Prolia (denosumab)

A 23-year-old presents to the emergency department with progressive symptoms. It starts with tingling in the fingertips that lead to leg cramps that turn into feeling like she's turning into stone, frozen in one position with stabbing pain. And perhaps most troubling, she can't concentrate. In fact, the brain fog is so severe that she's afraid to drive.  Over the course of three days, her life has been turned upside down. She takes a taxi to the emergency department and is seen after waiting six hours. She provides a quick medical history, noting she recently had neck surgery for parathyroid overactivity — an important clue to her diagnosis. Parathyroid glands produce parathyroid hormone that regulates the blood calcium level, which maintains bone strength and helps muscles and nerves function. Calcium levels in the blood have to be kept at a very specific level. Just like in your physiology lectures: HYPERcalcemia and HYPOcalcemia. And calcium levels that are either too high or too low can be deadly. But in moving quickly in the emergency department, testing for serum calcium is overlooked. A patient with recent neck surgery has symptoms consistent with low blood calcium levels —  why not check her calcium? It's true that in a chaotic ER things can be overlooked. But a lot of time, calcium isn't ordered because it's not part of the regular "electrolyte” or “chemistry” panel — it has to be added specifically. With computer systems and the way test panels like these are built, they can shape the thinking of physicians, putting certain symptoms front of mind, while others might get neglected. Fortunately, a diagnosis was caught early enough for this patient that no long-term damage was done. But this case serves as a reminder that although rare diseases are rare, it doesn't mean as a healthcare professional, you'll never encounter them.

Take Home Points Severe hypocalcemia can cause hypotension and QTc prolongation leading to Torsades de Pointes.  Treat moderate to severe symptoms and any EKG changes with IV calcium salts Always search for and treat the underlying cause of hypocalcemia REBEL Core Cast 88.0 – Hypocalcemia Click here for Direct Download of the Podcast Definition: A ... Read more The post REBEL Core Cast 88.0 – Hypocalcemia appeared first on REBEL EM - Emergency Medicine Blog.

At birth, Jessica's physician noticed she had low levels of calcium. Genetic testing later confirmed that she had autosomal dominant hypocalcemia type 1 (ADH1) with a calcium receptor (CaSR) gene mutation. Jessica had complications due to ADH1 quite early in life. Before Jessica started kindergarten, she had painfully passed her first kidney stone. Fiercely protective and attentive, Jessica's mother quit her job to take care of Jessica full-time. She researched and provided Jessica with the latest cutting-edge treatments.  Despite the challenges of living with ADH1, Jessica has done well. She is a hopeful, new mother who is ready to do whatever it takes to take care of her child. She has a graduate degree and works to provide mental health care for her clients. Mary Scott Roberts, M.D., senior director of clinical development at BridgeBio Cardiorenal, joins to provide an overview of ADH1. She describes how low or elevated levels of calcium can cause muscle cramps, brain fog, fatigue, seizures, and other symptoms in individuals living with ADH1.

Doc Mitchell was and GA, ST and SOST EM Doc who performed the first pre hosptial combat reboa. In this episode he discusses a key article reviewing the pathophysiology of the Lethal Triad and now the diamond of death. Hypocalcemia is implicated in reduced myocardial contractility, loss of vascular tone, and several impacts on the clotting cascade. Doc put this together for the medics and covers down on calcium cholride vs calcium gluconate/ TOML

Written by: Dr. Samantha Bruzzese (Internal Medicine Resident) Reviewed by:  Dr.Joshua Lakoff (Endocrinology) Dr. Zijing Wu (General Internal Medicine)Produced by: Margaret Sun Infographic by: Lilly Yu Support the show

Listen as Dr. London Smith (.com) and his producer Cameron discuss Hypocalcemia with Stretch (Nick Coluzzi of WizWorldLive). Not so boring! https://www.patreon.com/join/jockdocpodcast Hosts: London Smith, Cameron Clark. Guest: Nick Coluzzi. Produced by: Dylan Walker Created by: London Smith

The BONES store the most calcium – remember these words that rhyme with BONES to help you remember possible signs and symptoms of hypercalcemia.

In this short, but ultra HY podcast, I discuss the vast majority of what you need to know in relation to hypocalcemia for your USMLE exams. I spend a lot of time discussing mechanisms, pathophysiology, treatments, diagnostic approaches, and other key exam details. Audio Download

A quick primer on hypocalcemia in the ED. Hosts: Joseph Offenbacher, MD Audrey Bree Tse, MD https://media.blubrry.com/coreem/content.blubrry.com/coreem/hypocalcemia.mp3 Download Leave a Comment Tags: calcium, Critical Care, Endocrine Show Notes

A quick primer on hypocalcemia in the ED. Hosts: Joseph Offenbacher, MD Audrey Bree Tse, MD https://media.blubrry.com/coreem/content.blubrry.com/coreem/hypocalcemia.mp3 Download Leave a Comment Tags: calcium, Critical Care, Endocrine Show Notes

Hypocalcemia in goats, sometimes called milk fever, is one of the most misunderstood maladies in the goat world. This confusion stems from research done on cows, which does not apply to goats, but is still often referenced by many sources as if it does apply.Today's guest, Dr. Robert Van Saun of Pennsylvania State University, once again reminds us that goats are not little cows. We are talking about the causes of hypocalcemia in goats and how that compares to cows, as well as how to prevent it and the treatment.Dr. Van Saun talks about intravenous, sub-q, and oral treatment, and how quickly we should expect each one to work.We also discuss the relationship between hypocalcemia and pregnancy toxemia and how a diet to prevent one can also help to prevent the other. Full show notes here -- https://thriftyhomesteader.com/hypocalcemia-in-goats/To see the most recent episodes, visit  ForTheLoveOfGoats.comWant to support the content you love?Head over to -- https://thrifty-homesteader.ck.page/products/love-goats-tip-jar

En este nuevo episodio hablo del Diamante letal en trauma. Pasamos de la triada letal con la acidosis, coagulopatía e hipotermia y añadimos hipocalcemia en el manejo al paciente con trauma grave. Espero que os guste. Bibliografía consultada: - Ditzel, Ricky, Anderson, Justin, Eisenhart, William, Rankin, Cody, DeFeo, Devin, Oak, Sangki, et al. (2020). A review of transfusion- and trauma-induced hypocalcemia: Is it time to change the lethal triad to the lethal diamond?. Journal of Trauma and Acute Care Surgery, 88, 434-439. https://doi.org/10.1097/TA.0000000000002570 - Bjerkvig CK, Strandenes G, Eliassen HS, Spinella PC, Fosse TK, Cap AP, Ward KR. "Blood failure" time to view blood as an organ: how oxygen debt contributes to blood failure and its implications for remote damage control resuscitation. Transfusion. 2016;56(Suppl 2):S182-S189. - Dyer M, Neal MD. Defining the lethal triad. In: Pape HC, Peitzman A, Rotondo M, Giannoudis P, eds. Damage Control Management in the Polytrauma Patient. Cham, Switzerland: Springer; 2017:41-53. - Dobson GP, Letson HL, Sharma R, Sheppart FR, Cap AP. Mechanisms of early trauma-induced coagulopathy: the clot thickens or not? J Trauma. 2015;79(2):301-309. - Eddy VA, Morris JA Jr., Cullinane DC. Hypothermia, coagulopathy, and acidosis. Surg Clin North Am. 2000;80(3):845-854. - Niles SE, McLaughlin DF, Perkins JG, Wade CE, Li Y, Spinella PC, Holcomb JB. Increased mortality associated with the early coagulopathy of trauma in combat casualties. J Trauma. 2008;64(6):1459-1465. - Martini WZ, Holcomb JB. Acidosis and coagulopathy: the differential effects on fibrinogen synthesis and breakdown in pigs. Ann Surg. 2007;246(5):831-835. - Armand R, Hess JR. Treating coagulopathy in trauma patients. Transfus Med Rev. 2003;17(3):223-231. - Hastbacka J, Pettila V. Prevalence and predictive value of ionized hypocalcemia among critically ill patients. Acta Anaesthesiol Scand. 2003;47:1264-1269. - Cherry RA, Bradburn E, Carney DE, Shaffer ML, Gabbay RA, Cooney RN. Do early ionized calcium levels really matter in trauma patients? J Trauma. 2006;64(4):774-779. - Holcomb JB, Jenkins D, Rhee P, et al. Damage control resuscitation: directly addressing the early coagulopathy of trauma. J Trauma. 2007;62(2):307-310. - Lier H, Krep H, Schroeder S, Stuber F. Preconditions of hemostasis in trauma: a review. The influence of acidosis, hypocalcemia, anemia, and hypothermia on functional hemostasis in trauma. J Trauma. 2008;65(4):951-960. - Hoffman M, Monroe DM. Coagulation 2006: a modern view of hemostasis. Hematol Oncol Clin North Am. 2007;21:1-11. - Hoffman M. A cell-based model of coagulation and the role of factor VIIa. Blood Rev. 2003;17(suppl 1):S1-S5. - Ho KM, Leonard AD. Concentration-dependent effect of hypocalcaemia on mortality of patients with critical bleeding requiring massive transfusion: a cohort study. Anaesth Intensive Care. 2011;39(1):46-54. - Magnotti LJ, Bradburn EH, Webb DL, Berry SD, Fischer PE, Zarzaur BL, Schroeppel TJ, Fabian TC, Croce MA. Admission ionized calcium levels predict the need for multiple transfusions: a prospective study of 591 critically ill trauma patients. J Trauma. 2011;70(2):391-397. - Kornblith LZ, Howard BM, Cheung CK, et al. The whole is greater than the sum of its parts: hemostatic profiles of whole blood variants. J Trauma Acute Care Surg. 2014;77(6):818-827. - Li K, Xu Y. Citrate metabolism in blood transfusions and its relationship due to metabolic alkalosis and respiratory acidosis. Int J Clin Exp Med. 2015;8(4):6578-6584. - Giancarelli A, Liu-Deryke X, Birrer K, Hobbs B, Alban R. Hypocalcemia in trauma patients receiving massive transfusion. J Surg Res. 2016;202:182-187. - Webster S, Todd S, Redhead J, Wright C. Ionised calcium levels in major trauma patients who received blood in the emergency department. Emerg Med J. 2016;33(8):569-572. - Kyle T, Greaves I, Beynon A, Whittaker V, Brewer M, Smith J. Ionised calcium levels in major trauma patients who received blood en route to a military medical treatment facility. Emerg Med J. 2017;35(3):176-179. - MacKay EJ, Stubna MD, Holena DN, Reilly PM, Seamon MJ, Smith BP, Kaplan LJ, Cannon JW. Abnormal calcium levels during trauma resuscitation are associated with increased mortality, increased blood product use, and greater hospital resource consumption: a pilot investigation. Anesth Analg. 2017;125(3):895-901. - Shackelford SA, Del Junco DJ, Powell-Dunford N, Mazuchowski EL, Howard JT, Kotwal RS, Gurney J, Butler FK Jr., Gross K, Stockinger ZT. Association of prehospital blood product transfusion during medical evacuation of combat casualties in Afghanistan with acute and 30-day survival. JAMA. 2017;318(16):1581-1591. - DailyMed - Teruflex blood bag system anticoagulant citrate phosphate dextrose adenine (CPDA-1) - anticoagulant citrate phosphate dextrose adenine (cpda-1) solution. US National Library of Medicine. 2012. - Cap AP, Gurney J, Spinella PC, et al. Damage Control Resuscitation (CPG ID:18). Joint Trauma Service Clinical Practice Guideline. Joint Trauma System, the Department of Defense Center of Excellence for Trauma. 2019. - Pedersen KO. Binding of calcium to serum albumin. II. Effect of pH via competitive hydrogen and calcium ion binding to the imidazole groups of albumin. Scand J Clin Lab Invest. 1972;29(1):75-83. - Maxwell MJ, Wilson MJ. Complications of blood transfusion. BJA Educ. 2006;6(6):225-229. - Lang RM, Fellner SK, Neumann A, Bushinsky DA, Borow KM. Left ventricular contractility varies directly with blood ionized calcium. Ann Intern Med. 1988;108(4):524-529.

A look at Hypercalcemia, Hypocalcemia, Calcium requirements, calcium Supplements, and sources of calcium in your diet. --- This episode is sponsored by · Anchor: The easiest way to make a podcast. https://anchor.fm/app Support this podcast: https://anchor.fm/zebra-pig/support

Faine. (n.d.). The calcium quandry. EP Monthly. http://epmonthly.com/article/the-calcium-quandry Farkas. (2020). IBCC. Available at http://emcrit.org/ibcc Graudins, et. al. (2016). Calcium channel antagonist and beta blocker overdose: antidotes and adjunct therapies. Br J Clin Pharm 81(3). Nickson. (2020). Hypocalcemia. LITFL Blog. Available at http://litfl.com/hypocalcemia Sauter, et al. (2015). Calcium disorders in the ED: independent risk factors for mortality. PLoS One 10(7). Swaminathan. (2017). CORE EM: Hypocalcemia. Available at http://www.emdocs.net/core-em-hypocalcemia Webster, et. al. (2016). Ionised calcium levels in major trauma patients who received blood in the ED. Emer Med J 33(8). This podcast is hosted by ZenCast.fm

Interview with Adeel Abbas Dhahri, MS, MRCS, author of Prophylactic Steroids for Postthyroidectomy Hypocalcemia and Voice Dysfunction

Interview with Adeel Abbas Dhahri, MS, MRCS, author of Prophylactic Steroids for Postthyroidectomy Hypocalcemia and Voice Dysfunction

Episode Summary In this episode of the APEX Live Anesthesia podcast, we review the essentials of calcium and the physiologic consequences that occur when this important cation becomes low. We'll discuss how the body regulates calcium, the signs of hypocalcemia, something called the “Lethal Diamond” and so much more. APEX family…grab a big glass of milk and let's talk calcium! What You'll Learn     Assess how the body regulates calcium.      Examine normal calcium values.     Discuss the physiologic manifestations of acute and chronic hypocalcemia.     Explain the concept of the “Lethal Diamond”.     Review effective methods to replace calcium.   Want to Attend an APEX Live Event? We know that you miss going to live events right now - and we do too! That's why we decided to pull out all the stops on our APEX Live Virtual CPC Review Course. By attending virtually, there are no long flights, no rental cars, and no forgetting things at home. You can even show up in your PJs if you'd like! If you want an engaging review for the NBCRNA CPC Exam, with the flexibility to attend virtually, then you came to the right place. Our previous events were a blast! Check out the rest of our 2021 dates in the link below. Click here to learn more.   How Are We Doing? We're here to help you improve your practice, and we want to make sure our content is relevant for you. Click here to share your thoughts.   Legal Disclaimer APEX Anesthesia Review, LLC and APEX Live expressly disclaim any liability in connection with the use of any content in its podcasts, social media posts, and all other published content by any third party. Podcast music by Eino Toivanen, kongano.com  

In this video podcast, Eric takes a look at the concept of damage control resuscitation and the new concept of the "Lethal Trauma Diamond". In this podcast we dive into all things trauma resuscitation, focusing on current evidence-based practice as it relates to component therapy (1:1:1), whole blood administration, and the four components of the lethal diamond. We investigate the newest of the four, hypocalcemia, and look at the pathophysiology around ionized calcium and the impact on coagulopathy. This is an information-packed episode, with a focus on current evidence-based practice and treatment guidelines. Don't miss it! Please like and review on your current podcast app, including Spotify, Google Play, iTunes, PodBean, and many more. See omnystudio.com/listener for privacy information.

In this video podcast, Eric takes a look at the concept of damage control resuscitation and the new concept of the "Lethal Trauma Diamond". In this podcast we dive into all things trauma resuscitation, focusing on current evidence-based practice as it relates to component therapy (1:1:1), whole blood administration, and the four components of the lethal diamond. We investigate the newest of the four, hypocalcemia, and look at the pathophysiology around ionized calcium and the impact on coagulopathy. This is an information-packed episode, with a focus on current evidence-based practice and treatment guidelines. Don't miss it! Please like and review on your current podcast app, including Spotify, Google Play, iTunes, PodBean, and many more.

In this video podcast, Eric takes a look at the concept of damage control resuscitation and the new concept of the "Lethal Trauma Diamond". In this podcast we dive into all things trauma resuscitation, focusing on current evidence-based practice as it relates to component therapy (1:1:1), whole blood administration, and the four components of the lethal diamond. We investigate the newest of the four, hypocalcemia, and look at the pathophysiology around ionized calcium and the impact on coagulopathy. This is an information-packed episode, with a focus on current evidence-based practice and treatment guidelines. Don't miss it! Please like and review on your current podcast app, including Spotify, Google Play, iTunes, PodBean, and many more.

What does IDM stand for? In the medical world, IDM is an acronym for Infant of Diabetic Mother. In this episode, we review the common complications associated with Infants of Diabetic Mothers. You may be surprised to hear that there are several complications beyond hypoglycemia or low blood sugars including but not limited to macrosomia, asphyxia, small for gestational age, respiratory distress, cardiac anomalies, neurological impairments, polycythemia, hyperbilirubinemia, hypocalcemia, and hypomagnesemia. Plus IDM infants are also at an increased risk for a preterm delivery and/or a cesarean section delivery due to their risk of complications later during the pregnancy or potentially larger size. Not only will we break down the potential complications the IDM infant is at risk for one-by-one, but we also discuss the pathophysiology behind each diagnosis as well as the typical treatment plan for each complication. If you are currently pregnant and have been diagnosed with gestational diabetes or had pre existing diabetes, this episode is for you! Or if you just had your baby and had diabetes with the pregnancy, this episode will provide you some great education. Empowering NICU Parents Show Notes: https://empoweringnicuparents.com/episode19/Empowering NICU Parents Instagram: https://www.instagram.com/empoweringnicuparents/Empowering NICU Parents FB Group:https://www.facebook.com/groups/empoweringnicuparentsWebsite Link: https://empoweringnicuparents.com/episode19/

A high-yield question-based review of clinical points related to childhood hypocalcemia with approach to its differential diagnoses and evaluation of pseudohypocalcemia, followed by a discussion of Rickets and Osteomalacia.

Today's episode is dedicated to Tumor Lysis Syndrome management in the PICU. Join us as we discuss the patient case, symptoms, and treatment. We are delighted to be joined by Dr. Himalee Sabnis, Assistant Professor of Pediatrics at Emory University School of Medicine. She is also a pediatric hematologist/oncologist and the Co-Director of the High-Risk Leukemia Team at the AFLAC Cancer & Blood Disorders Center at Children's Healthcare of Atlanta.  Show Highlights: Our case, symptoms, and diagnosis: A three-year-old female with pre-B ALL presents on Day 2 of chemotherapy to the PICU. She is admitted with telemetry findings of arrhythmia, decreased urine output, and an EKG notable for peaked T waves. Her labs are notable for elevated WBC, hyperkalemia, hyperphosphatemia, and low ionized calcium. Tumor Lysis Syndrome is a life-threatening medical emergency stemming from rapid tumor cell destruction that overwhelms the usual metabolic and excretory pathways.  Why TLS is the most common pediatric oncologic emergency for pediatric cancer patients When the tumor cells die or lyse, what's inside those cells comes out into the blood Key metabolic abnormalities that affect organ function are too much potassium and phosphorus, low calcium, and uric acid buildup. Those metabolic abnormalities can result in cardiac arrhythmia and kidney failure. Certain patient populations have an increased risk for TLS: Hematological cancers have a higher risk than solid tumors Patients with fast-growing tumors, like lymphoma and leukemia, are at high risk Key pathophysiologic principles that drive TLS: The imbalance of electrolytes can impact heart function TLS is characterized by hyperkalemia, hyperphosphatemia, hypocalcemia, and uric acid, which is a by-product of DNA breakdown If untreated, the uric acid can lead to acute kidney injury and renal failure Electrolyte and metabolic disturbances can progress to renal insufficiency, cardiac arrhythmias, seizures, and death TLS releases cytokines that can cause a systemic inflammatory response and multi-organ failure Other lab markers in patients with TLS include uric acid, LDH, CBC, DIC panel, and daily blood gas (these are typically trended every 4-6 hours). Key factors in TLS management are to understand the risk and know your resources. Steps taken would be continuous cardiac monitoring, uric acid control, administering Allopurinol to combat uric acid formation, and managing electrolyte disturbances in conjunction with an intensivist. Chemotherapy would not be delayed due to TLS because the patient's condition won't improve until the cancer is treated. How the complications of TLS are treated: Hyperphosphatemia should be treated by using oral phosphate binders such as aluminum hydroxide. Hypocalcemia does not require therapy unless cardiac function is affected. How renal replacement therapy might be required and indications are similar to other forms of acute kidney injury. Besides Allopurinol being given at the initiation of chemotherapy, patients at high risk for TLS may receive low-intensity initial therapy to prevent rapid cell lysis. Takeaway clinical pearls regarding TLS: Know what you're dealing with because every cancer is different. Fluid management is important and will vary from patient to patient. Be proactive in monitoring. Intervene early and quickly.  

Today we discuss causes of hypocalcemia and how to treat hypocalcemia.

In this episode, Ricky Ditzel joins us to discuss the role of calcium in trauma patients. Ricky is a former critical care flight paramedic for the 160th Special Operations Aviation Regiment (SOAR), currently a pre-medical student at Colombia University, and the lead author of a groundbreaking paper on the role of calcium in the decompensation cycle in trauma. Ricky talks with us about how calcium works in the body, how trauma induces hypocalcemia, and how the flight medic can use calcium during trauma resuscitation.Ricky's original article in the Journal of Trauma and Acute Care Surgery: Ditzel RM Jr, Anderson JL, Eisenhart WJ, Rankin CJ, DeFeo DR, Oak S, Siegler J. A review of transfusion- and trauma-induced hypocalcemia: Is it time to change the lethal triad to the lethal diamond? J Trauma Acute Care Surg. 2020 Mar;88(3):434-439. doi: 10.1097/TA.0000000000002570. PMID: 31876689.The recent article in the American Journal of Emergency Medicine:Wray JP, Bridwell RE, Schauer SG, Shackelford SA, Bebarta VS, Wright FL, Long B. The diamond of death: Hypocalcemia in trauma and resuscitation. Am J Emer Med. 2021 Mar;41(1):104-109. doi:10.1016/j.ajem.2020.12.065Ricky mentions a study in which 97% of transfusion patients were hypocalcemic. That study is here:Giancarelli, A., Birrer, K. L., Alban, R. F., Hobbs, B. P., & Liu-DeRyke, X. (2016). Hypocalcemia in trauma patients receiving massive transfusion. Journal of Surgical Research, 202(1), 182-187. If you want to use this episode as part of your Tables III medical training, use the following tasks per TC 8-800.081-833-0034 Manage an Intravenous Infusion081-835-3002 Administer Medications by IV Piggy Back

Related FOAM Posts http://www.tamingthesru.com/blog/2020/1/24/hypocalcemia-in-trauma Continue reading The post Episode 30: Hypocalcemia Resulting from Trauma & Blood Product Transfusion appeared first on The Pharm So Hard Podcast.

In this episode, we review the topic of Hypocalcemia from the Basic Science section. --- Send in a voice message: https://anchor.fm/orthobullets/message

Although veterinarians may not be administering individual treatment to clinical, recumbent milk fever cases, there are many opportunities for us to be involved with preventing, monitoring, and developing protocols for treatment of hypocalcemia. In this episode, AABP Executive Director Dr. Fred Gingrich is joined by Dr. Jess McArt, a clinician and researcher from Cornell University. Dr. McArt discusses practical tips for diagnosing and treating cases of clinical hypocalcemia, as well as providing suggestions for veterinary involvement in prevention and monitoring of this disease. We also discuss the effects of subclinical hypocalcemia, which can be diagnosed in 30-50% of cows on some dairy farms, even with a clinical incidence rate of well under 5%. Dr. McArt also discusses some of the research on hypocalcemia, including a recent project that demonstrated blood samples taken pre-treatment can sit in cold storage for an extended period without adversely affecting accuracy of results for blood calcium levels. Dr. McArt also discusses future research, including the effects of transient, persistent, or delayed subclinical hypocalcemia in early lactation cows. AABP members can listen to Dr. McArt’s research summary presentations on calcium by going to the BCI CE portal and searching under the Research Summaries or the Annual Conference Proceedings and searching for McArt. Relevant publications: McArt JAA, Neves RC. Association of transient, persistent, or delayed subclinical hypocalcemia with early lactation disease, removal, and milk yield in Holstein cows. J Dairy Sci. 2020 Jan;103(1):690-701. doi: 10.3168/jds.2019-17191. Epub 2019 Nov 6. PMID: 31704009 Bach KD, Neves RC, Stokol T, McArt JAA. Technical note: Effect of storage time and temperature on total calcium concentrations in bovine blood. J Dairy Sci. 2020 Jan;103(1):922-928. doi: 10.3168/jds.2019-17394. Epub 2019 Nov 14. PMID: 31733856. Neves RC, Stokol T, Bach KD, McArt JAA. Method comparison and validation of a prototype device for measurement of ionized calcium concentrations cow-side against a point-of-care instrument and a benchtop blood-gas analyzer reference method. J Dairy Sci. 2018 Feb;101(2):1334-1343. doi: 10.3168/jds.2017-13779. Epub 2017 Dec 14. PMID: 29248221. Leno BM, Neves RC, Louge IM, Curler MD, Thomas MJ, Overton TR, McArt JAA. Differential effects of a single dose of oral calcium based on postpartum plasma calcium concentration in Holstein cows. J Dairy Sci. 2018 Apr;101(4):3285-3302. doi: 10.3168/jds.2017-13164. Epub 2018 Feb 14. PMID: 29454686. Neves RC, Leno BM, Stokol T, Overton TR, McArt JAA. Risk factors associated with postpartum subclinical hypocalcemia in dairy cows. J Dairy Sci. 2017 May;100(5):3796-3804. doi: 10.3168/jds.2016-11970. Epub 2017 Mar 16. PMID: 28318576.

Interested about low calcium this is the episode for you

Hypocalcemia in dairy cattle is not a new phenomenon, however, researchers are making progress on understanding nutrition and management strategies to mitigate the change in calcium that occurs around calving. Dr. Jesse Goff, a leading researcher on hypocalcemia, has recently provided an update on hypocalcemia in dairy cows. This episode of the Purdue Dairy Digest will talk about an update from Dr. Jesse Goff on hypocalcemia.

Episode 10- First off thanks everyone for the support thus far. I can't wait to see what the next ten episodes brings.This week we take a look at our Medical Sign's! I tell everyone I'm an Aquarius (I don't know what that means) and start by. giving a much deserved shout out to you guys the fans and listeners.We take a look at things to come as we move away from medical and into Trauma!Some of the main topic we look at today signs that point us to Skull Fractures, Pancreatitis, Ectopic Pregnancy, Hypocalcemia, Pelvic Bleeding, and several others.We wrap with another thank you and closing comments. Reach out to the page and tell us what you want to hear or if you want to be a guest on the show I would love to have a discussion about a topic.

This week on @MedTwitThisWeek, I am joined by Dr. H. Moses Murdock (@haematognomist) as we discuss his tweet on tips for #InternOrientation, the Behind the Scenes in developing #VirtualMorningReport and more! Published June 19, 2020 Host: Chris "The Chiu Man" Chiu Guest: H. Moses Murdock My pick of the week is @haematognomist #Tweetorial of Tweetorials for Interns: https://twitter.com/haematognomist/status/1272540673066106881?s=21 Thanks to @MedTweetorials and @rosenelliem for their “Most Viewed Tweetorials” of the week… Henceforth #MVTOTW (maybe).... @tony_breu knocks another one out of the park with his diuretic coffee thread: https://twitter.com/tony_breu/status/1271529206518812675?s=21 @runthelistpod's excellent thread on Hypercalcemia: https://twitter.com/runthelistpod/status/1271134213018968068?s=21 @davidsteensma's #Tweetstory on the confusing nomenclature of “myelo-” https://twitter.com/davidsteensma/status/1269794585972224001?s=21 @opsbug's #ReflectionThread on @CPSolver's #VirtualMorningReport on GBS…. https://twitter.com/opsbug/status/1270509749403095041?s=21 Onto my picks, first is @JustinBerk @DoctorWatto @PaulNWilliamz who published their “Twelve Tips for creating a medical education podcast” https://twitter.com/paulnwilliamz/status/1273206734321070081?s=21 @aoglasser @RJmdphilly @michellebr00ks published in a special issue of “Seminars in Nephrology” about Twitter and it's new role in medicine: https://twitter.com/aoglasser/status/1273022360803827713?s=21 H/T to @anthony_nguyen9 on another article featuring @DrRayMD and discussing #SDH https://twitter.com/anthony_nguyen9/status/1272911692972863495?s=21 More beautiful prose from @TheRealDoctorT! https://twitter.com/therealdoctort/status/1272938526615703555?s=21 @haematognomist's first pick is another @runthelistpod thread! This time focusing on Hypocalcemia

Association of transient, persistent, or delayed subclinical hypocalcemia with early lactation disease, removal, and milk yield in Holstein cows Find the Big 3 Infographic at otovets.com/cuttingedge Link: https://www.journalofdairyscience.org/article/S0022-0302(19)30971-3/fulltext See the referenced research graphs by joining OTO at otovets.com/facebook Big Take Away #1: The subclinical hypocalcemic (SCH) state of the post-paturm cow is better described by four states; normal calcemic, transient, persistent and delayed. Each state represents a different metabolic response to the demands of lactation and an increase or decrease in disease and removal incidence as well as production outcome. Big Take Away #2: Primiparous dams undergoing a persistent SCH state were 4x more likely to undergo a health or removal event vs normal calcemic while multiparous dams were almost 2x more likely. Similarly, primiparous dams undergoing a delayed SCH state were 3x more likely to undergo a health or removal event vs normal calcemic dams while multiparous dams were again 2x more likely. Big Take Away #3: The transient SCH state is associated with 5.5 more lbs per day of milk production in first lactation animals and 12.1 more lbs per day of milk production in second and greater animals. This state represents a cow that is metabolically well adapted and is experiencing a natural calcium suppression due to production demands that the body responds too. Ultimate Message: This study expands our understanding of SCH and it’s different states. By understanding that there is a subpopulation of cows that naturally undergo this state but can still produce above their peers we are better able to create targeted therapies and better identify cows that could be potential problems down the road. Association of transient, persistent, or delayed subclinical hypocalcemia with early lactation disease, removal, and milk yield in Holstein cows Published by J. A. A. Mc Art, R. C. Neves Location: New York, researchers form Cornell and Purdue Objective: Our objective was to assess the association of early postpartum Ca status group, classified as normocalcemia (NC), transient SCH (tSCH), persistent SCH (pSCH), or delayed SCH (dSCH), with early lactation disease diagnosis, culling, and milk yield. A secondary objective was to assess changes in blood BHB and plasma fatty acid concentrations in the first 10 DIM between cows in different early postpartum Ca status groups.

Dr. OP Hamnvik, an endocrinologist and medical educator at Brigham and Women’s Hospital, joins Joyce Zhou (host) and Dr. Emily Gutowski (case presenter) to discuss hypocalcemia. They run through a case of a patient with a recent thyroidectomy who presents with perioral paresthesia and hypocalcemia. Dr. Hamnvik takes us through the many causes of hypocalcemia, from the PTH-dependent to the PTH-independent causes, in addition to ways in which we can test for hypocalcemia at the bedside through Chvostek's & Trousseau's signs. Dr. Hamnvik gives us a quick refresher on calcium homeostasis, vitamin D metabolism, and the various ways in which these can go awry to cause hypocalcemia. The conversation ends with a discussion of the classic hypocalcemia labs, treatment decision-making, and several clinical pearls from Emily & Dr. Hamnvik! https://www.runthelistpodcast.com/endocrinology/#hypocalcemia

In this episode we cover the last common electrolyte derangement you'll face in the ICU; hypocalcemia. From tetany to hypotension, we've got you covered for an approach to recognition and treatment.

Tumor Lysis Syndrome + MCQ from chapter titled Emergencies in Hematology and Oncology in Baliga's Textbook of Internal Medicine available at MasterMedFacts.com authored by Thorvardur Halfdanarson,MD Professor of Oncology Mayo Clinic, Rochester, MN & Eric Engelman, MD Clinical Hematologist/Oncologist Dubuque, Iowa Not Medical Advice or Opinion  

Lactic Acidosis in Malignancies + MCQ from chapter titled Emergencies in Hematology and Oncology in Baliga's Textbook of Internal Medicine available at MasterMedFacts.com authored by Thorvardur Halfdanarson,MD Professor of Oncology Mayo Clinic, Rochester, MN & Eric Engelman, MD Clinical Hematologist/Oncologist Dubuque, Iowa Not Medical Advice or Opinion  

My notes based on calcium imbalances, hypo and hypercalcemia

The US dairy industry has made great progress at reducing clinical hypocalcemia in herds. However, we are still trying to understand subclinical hypocalcemia. New research indicates that even within cows that are diagnosed as having subclinical hypocalcemia, cows may recover to normal at different rates. Cows that are able to recover quickly, may be ones that we should not intervene with, however the challenge is being able to identify which ones truly need treatment.

Talk to a Dr. Berg Keto Consultant today and get the help you need on your journey (free consultation). Call 1-540-299-1557 with your questions about Keto, Intermittent Fasting, or the use of Dr. Berg products. Consultants are available Monday through Friday from 8:30 am to 9 pm EST. Saturday & Sunday 9 am to 5 pm EST. USA Only. Take Dr. Berg's Free Keto Mini-Course! DATA: Alkalosis Symptoms: https://www.youtube.com/watch?v=m_AKd... Hypocalcemia: https://www.youtube.com/watch?v=YWPaz... Low Magnesium: https://www.youtube.com/watch?v=m3Dvy... Low Potassium: https://www.youtube.com/watch?v=q2vPQ... In this podcast, we're going to talk about the three main causes of twitching (tetany). If you experience tetany signs like eyelid twitching, this video is for you. Dr. Eric Berg DC Bio: Dr. Berg, 51 years of age is a chiropractor who specializes in weight loss through nutritional & natural methods. His private practice is located in Alexandria, Virginia. His clients include senior officials in the U.S. government & the Justice Department, ambassadors, medical doctors, high-level executives of prominent corporations, scientists, engineers, professors, and other clients from all walks of life. He is the author of The 7 Principles of Fat Burning. ABOUT DR. BERG: https://bit.ly/2FwSQQT DR. BERG'S STORY: https://bit.ly/2RwY5GP DR. BERG'S SHOP: https://bit.ly/2RN11yv DR. BERG'S VIDEO BLOG: https://bit.ly/2AZYyHt DR. BERG'S HEALTH COACHING TRAINING: https://bit.ly/2SZlH3o Follow us on FACEBOOK: https://www.messenger.com/t/drericberg TWITTER: https://twitter.com/DrBergDC YOUTUBE: https://www.youtube.com/user/drericberg123 Send a Message to Dr. Berg and his team: https://www.messenger.com/t/drericberg

Liver transpl: Reperfusion effect effect; Liver transpl: Electrolyte disturbances; Liver transpl: Hypocalcemia etiology; Hypocalcemia: ECG effects 

Neither Dr. Dimitre or Dr. Kevin like electrolytes, but talk about them they must. Dr. Kevin starts off with hypocalcemia, covering his approach in the ER department. Dr. Dimitre makes some suggestions about dealing with hypocalcemia in the family doctor’s office. Please go to our member’s area to access the podcast! Posted on 27/07/2016 by […] The post Episode 27: Hypocalcemia appeared first on Primary Medicine Podcast.

CATS of hypocalcemia Convulsions Arrhythmias Tetany Spasms and stridor   Groans, Moans, Bones, Stones, Overtones Groans – constipation Moans – joint pain Bones – loss of calcium from bones Stones – kidney stones Overtones – psychiatric overtones (confusion, depression) The post Ep5: Hypercalcemia/Hypocalcemia (CATS, Groans/Moans/Bones/Stones/Overtones) appeared first on NURSING.com.

It is well documented that human trauma patients with low levels of ionized calcium at admission are at increased risk for death. As calcium has many important functions in the body, hypocalcemia can lead to numerous systemic abnormalities. In this veterinary podcast, VetGirl evaluates the importance of calcium in the body -; particularly in veterinary trauma patients - and evaluates how calcium levels may affect overall treatment plan and outcome in veterinary medicine.

It is well documented that human trauma patients with low levels of ionized calcium at admission are at increased risk for death. As calcium has many important functions in the body, hypocalcemia can lead to numerous systemic abnormalities. In this veterinary podcast, VetGirl evaluates the importance of calcium in the body -; particularly in veterinary trauma patients - and evaluates how calcium levels may affect overall treatment plan and outcome in veterinary medicine.

Amy Nooyen, a student at the Purdue Veterinary School discusses the Treatment and Prevention of Milk Fever (Part 2 of 2)

Amy Nooyen, a student at the Purdue Veterinary School fills us in on the causes of milk fever (Part 1 of 2)