Podcasts about conserved

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Episode 19 - Indigenous Protected and Conserved Area's with Carrie Selin and Roy Auger What- Taken from a Webinar previously posted on Youtube on January 12, 2023. Indigenous Protected and Conserved Area's are lands and waters where Indigenous governments have the primary role in protecting and conserving ecosystems through Indigenous laws, governance and knowledge systems. Culture and language are the heart and soul of an IPCA. IPCA's vary in terms of their governance and management objectives. However, they generally share three essential elements: IPCA's are Indigenous-led, IPCA's represent a long- term commitment to conservation and IPCA's elevate Indigenous rights and responsibilities. Who - Carrie Selin is an environmental consultant providing project management support to Indigenous Communities that includes engaging community, teams, and partners to successfully execute project plans. She has extensive experience in facilitation, program planning, engagement and communication that supports the development and delivery of Indigenous economic and environmental projects. She works collaboratively with Indigenous communities to build capacity, identify community priorities, and facilitate processes to solve challenges. Carrie Selin, B.Sc. Project Management & Stakeholder Engagement - Solstice Environmental Management. Roy Auger is the Consultation Officer for the Buffalo Lake Metis Settlement and regularly responds to and address's proponents looking to complete projects within our traditional lands. Proponents that contact our office are mostly within the oil and gas industry, however, all projects including water, sewer, power, telecommunications and roadways are subject to the regulatory process, thus, they are obligated to seek our consultation when requesting project approval through the Alberta Government's Aboriginal Consultation Office. Music - Song: If Only You Knew. Composer: Vorsa Website: https://www.youtube.com/channel UCU27SVe_x0TF8kyVDndguvg License: Free To Use YouTube license youtube-free Music powered by BreakingCopyright: https://breakingcopyright.com

In a major step forward for wildlife conservation, over 1,800 hectares of critical habitat for iconic species such as Grizzly Bears, Moose, and Woodland Caribou in Northern British Columbia have been protected forever. Guest: Andy Day - CEO, BC Parks Foundation Learn more about your ad choices. Visit megaphone.fm/adchoices

GUEST: Andy Day, CEO, BC Parks Foundation Learn more about your ad choices. Visit megaphone.fm/adchoices

In this episode of the Epigenetics Podcast, we talked with Johnathan Whetstine from Fox Chase Cancer Center about his work on how histone demethylases affect gene expression and cancer cell stability. The Interview start by discussing a pivotal paper from Jonathan's lab in 2010, where they identified a role for the KDM4A histone demethylase in replication timing and cell cycle progression. They elaborate on the discoveries made regarding the link between histone marks, replication timing, and gene expression control. Jonathan explains the impact of microRNAs on regulating KDM4A and how protein turnover rates can influence cellular responses to treatments like mTOR inhibitors. Further, they explore the causal relationship between histone marks and replication timing, demonstrating how alterations in epigenetic regulation can affect genome stability. Jonathan shares insights from his latest research on H3K9 methylation balance at the MLL-KM2A locus, elucidating how these epigenetic modifications regulate amplifications and rearrangements in cancer cells. The episode concludes with a discussion on the establishment of the Cancer Epigenetics Institute at Fox Chase Cancer Center, aiming to bridge academia and industry to accelerate translational research in cancer epigenetics.   References Black, J. C., Allen, A., Van Rechem, C., Forbes, E., Longworth, M., Tschöp, K., Rinehart, C., Quiton, J., Walsh, R., Smallwood, A., Dyson, N. J., & Whetstine, J. R. (2010). Conserved antagonism between JMJD2A/KDM4A and HP1γ during cell cycle progression. Molecular cell, 40(5), 736–748. https://doi.org/10.1016/j.molcel.2010.11.008 Mishra, S., Van Rechem, C., Pal, S., Clarke, T. L., Chakraborty, D., Mahan, S. D., Black, J. C., Murphy, S. E., Lawrence, M. S., Daniels, D. L., & Whetstine, J. R. (2018). Cross-talk between Lysine-Modifying Enzymes Controls Site-Specific DNA Amplifications. Cell, 174(4), 803–817.e16. https://doi.org/10.1016/j.cell.2018.06.018 Van Rechem, C., Ji, F., Chakraborty, D., Black, J. C., Sadreyev, R. I., & Whetstine, J. R. (2021). Collective regulation of chromatin modifications predicts replication timing during cell cycle. Cell reports, 37(1), 109799. https://doi.org/10.1016/j.celrep.2021.109799 Gray, Z. H., Chakraborty, D., Duttweiler, R. R., Alekbaeva, G. D., Murphy, S. E., Chetal, K., Ji, F., Ferman, B. I., Honer, M. A., Wang, Z., Myers, C., Sun, R., Kaniskan, H. Ü., Toma, M. M., Bondarenko, E. A., Santoro, J. N., Miranda, C., Dillingham, M. E., Tang, R., Gozani, O., … Whetstine, J. R. (2023). Epigenetic balance ensures mechanistic control of MLL amplification and rearrangement. Cell, 186(21), 4528–4545.e18. https://doi.org/10.1016/j.cell.2023.09.009   Related Episodes The Impact of Chromatin Modifiers on Disease Development and Progression (Capucine van Rechem)   Contact Epigenetics Podcast on X Epigenetics Podcast on Instagram Epigenetics Podcast on Mastodon Epigenetics Podcast on Bluesky Epigenetics Podcast on Threads Active Motif on X Active Motif on LinkedIn Email: podcast@activemotif.com

No Time To Read podcast  S3E5  GRASSY TILLERS1 (GT1) and SIX-ROWED SPIKE1 (VRS1) homologs share conserved roles in growth repression       Guest: Joseph Gallagher, US Department of Agriculture (USDA), Agricultural Research Service (ARS)    Twitter/X: @Joe_P_Gallagher      Host: Arif Ashraf, Assistant Professor, Department of Biology, Howard University   Twitter/X: @aribidopsis 

Mike Switzer interviews Dale Threatt-Taylor, executive director of The Nature Conservancy in South Carolina.

Uveitis is a heterogenous group of inflammatory eye diseases for which current cytokine-targeted immune therapies are effective for only a subset of patients. Dr. Edmund Tsui is joined by Dr. Lynn M. Hassman and MD/PhD student Joseph B. Lin to explore potential common underlying mechanisms that exist for immune cell recruitment in uveitis in their Ophthalmology Science article, “Aqueous macrophages contribute to conserved CCL2 and CXCL10 gradients in uveitis” Aqueous Macrophages Contribute to Conserved CCL2 and CXCL10 Gradients in Uveitis. Lin, Joseph B. et al. Ophthalmology Science, Volume 4, Issue 4. The Ophthalmology-family of journals is now on Instagram. Follow aaojournal for clinical images, research articles, news, editorials, podcasts, and more! Sign up for the next Ophthalmology Journal Virtual Club on June 19, 2024, at https://store.aao.org/ophthalmology-virtual-journal-club.html

Once upon a time, a $35 million property, highly desirable for development, would have been out of reach for conservationists. But recently, our next guest's organization was able to accomplish exactly that with the purchase of a 4400-acre property on deep water along I-95 in our state.

Welcome to Episode 429 of the Outdoor Biz Podcast. Today I'm talking with Mark Holyoak, Director of Communication at the Rocky Mountain Elk Foundation. Mark has been in the communications business for 35 years. He spent the first 24 years as a television broadcast journalist in Kansas, Washington and Montana. In 2012, he accepted the position of director of communication at the Rocky Mountain Elk Foundation, where he oversees Bugle magazine, produces written and digital content, creates video scripts, and is responsible for all internal and external communications. He likes to hunt, fly fish, hike, play softball, basketball, and hockey, and ride his mountain unicycle with his kids. Facebook​ ​Twitter​ ​Instagram​ Love the show? Subscribe, ​rate, review, and share!​ Sign up for my Newsletter ​HERE​ I'd love to hear your feedback about the show! You can contact me here: ​rick@theoutdoorbizpodcast.com   Show Notes 00:00 As a child in the 70s and 80s, I spent most of my time outside, exploring the creek bottoms, catching crawdads, fishing, and playing with friends. It was a carefree time when we would leave the house in the morning and only return when it was dark. I have fond memories of hiking, skipping rocks, and playing with critters - typical kid stuff, really. 04:41 Fond memories of hunting with parents in Utah. 07:04 Bonding through outdoor activities, father and son. 11:11 Transitioned from news anchor to public relations director. 15:21 Father, a petroleum geologist, inspired deep love for profession. 17:12 Gaining factory work experience, learning from veterans. 19:31 Elk organization's efforts support wildlife and habitat conservation through fundraising and projects like forest thinning and prescribed burns. 24:34 Preserving land for public hunting and fishing access. 27:16 Addressing environmental and animal rights movements is crucial. These movements pose challenges such as limiting fishing and public access. Professional wildlife managers and biologists are essential for informed decision-making. 30:41 Hunting expeditions with family and friends in the mountains, seeking elk but not always successful, while also feeling excited about introducing the activity to a grandson and an unexpected interest from an older daughter. 33:24 Take decisive action and create opportunities. 37:47 I Considered buying various fly fishing bait colors. 39:29 Manages Elk Foundation publication staff and media monitoring. 44:04 Conserved 72,000 acres, opened access to 78,000. Large easement in Kentucky for public access. 36:52 What's one or two of your favorite books? I'm not really a book reader. I'm more of an online article reader. RMEF's Bugle Magazine. Although I do like John Grisham, I'll say that. 34:34 Favorite piece of Outdoor Gear under $100: So I really like fly fish. I buy the materials, and I tie my own flies. I really enjoy that. And so I came across my wife's embroidery thread. She had Orange for October caddises and olive green for olive caddises and black and yellow for really vibrant, for just Adam's flies or just all sorts of everything. And so I didn't purchase it. I'm like, Hey, when's the last time you did any of this? Oh, I don't really do that anymore. I'm going to take this bag, it has all these different colors in it. So it wasn't a purchase. It was more of just a pilfering. Right. And, but that's what I use. I mean, you can obviously go and get different types of materials from Sportsman's Warehouse or Cabela's or wherever you shop and make your own bodies. But I'm telling you that embroidery stuff works great Learn More To learn more about Mark and The Rocky Mountain Elk Foundation, visit their website at: https://www.rmef.org/ You can also visit The Rocky Mountain Elk Foundation on these social sites: YouTube Facebook X Instagram Next Steps If you enjoy interviews devoted to the outdoor industry, find us online at ricksaez.com/listen. We welcome likes and comments, and if you know someone who is also an outdoor enthusiast, go ahead and share our site with them, too. Keywords #Rocky Mountain Elk Foundation, #Elk hunting, #Conservation, #Advocacy, #Land conservation, #Access projects, #Habitat enhancement, #Wildlife overpass crossings, #Outdoor industry, #Wildlife management, #Outdoor excursions, #Family activities, #Volunteer projects, #BLM, #Forest service, #Highway wildlife migration, #Fly fishing, #Hunting skills, #Television broadcast journalist. Podcast produced using Descript, CastMagic Podcast hosted by Libsyn use code 'outdoorbizpod' for 20% OFF Show Notes powered by Castmagic Website powered by Wordpress Note: As an Affiliate of Amazon and others, I earn from qualifying purchases.

Thus Jehu wiped out Baal from Israel. But Jehu did not turn aside from the sins of Jeroboam the son of Nebat, which he made Israel to sin—that is, the golden calves that were in Bethel and in Dan. - 2 Kings 10:28   This Episode's Links and Timestamps: 00:24 – 2 Kings 10 07:02 – Thoughts on the Reading 35:25 - The largest religious group in the US? People who don't believe in anything. – John Knox, NTB 51:04 - Amazon Prime has a new animated series about heaven, hell, and how the devil is actually the good guy – John Knox, NTB 1:13:50 - Reconquista: Plausible and Necessary – Richard Ackerman, American Reformer --- Send in a voice message: https://podcasters.spotify.com/pod/show/garrett-ashley-mullet/message

This Day in Maine for Wednesday, January 10, 2024

People's Park Complex is being considered for conservation by the Government, a move which has been praised by heritage experts. However, some of the owners are not as happy, preferring complete redevelopment instead. Who's right? Elsewhere, residents in Sembawang have reacted with shock to the announcement that a new columbarium might be built near their homes. Is this another case of NIMBY rearing its ugly head?Find us here! YLB Subreddit YLB TikTok YLB IG YLB YouTube FolkloryIf you're looking for a meaningful gift, we'd love to help you create a personal podcast for a loved one. Get started at Folklory.com People's Park Complex to be Conserved People's Park Complex assessed to be of 'high heritage significance', may affect collective sale Heritage lovers laud People's Park Complex's possible conservation, but some say total rebuild better for business [Oct 2022] Golden Mile Complex gazetted as conserved building [Jan 2023] Pioneer architect behind People's Park Complex and Golden Mile Complex dies Residents Gripe about New Columbarium Residents fear plans of new columbarium complex in Mandai may affect property prices, impact en bloc deal New funeral and columbarium complex may be built in Mandai One Shiok Comment Comment by internetlurker96 Comment byEntire-Reflection954 One Shiok Thing League of Pigs Tiny Desk by Caroline Polachek Mics and Headphones from @shureChairs from @ergotunechairDesk from @castlerysgEdited and mixed by Tristen Yeak

On today's episode we discuss gun violence in music Follow our guests @qadirahx & @viraldebates @el__cabra @orgsimfreaks2.0 Led by Qadirah Abdur-Rahman @viraldebates, VIRAL Debates is an innovative discussion style program, where articulate speakers will examine a range of uncomfortable topics and relate its role in Black advancement. The show is focused on the advancement of Black Americans, also known as Freedman, also known as the descendants of those enslaved within the United States. If you are interested in joining the show, please email us viraltvnyc@gmail.com Question for comment section: Watch this show live on Youtube https://www.youtube.com/channel/UCU-St9gk559MmeOycu0sIUg Follow us on IG @viraldebates and twitter @viral_debates Tik Tok @viraldebates.show You can also listen to our episodes on Spotify https://open.spotify.com/show/6C5dNrcTgfAV0FHEBZSJbb?si=3TT6jHDgRpKXrZ-cf9Tnpg and Apple Podcasts https://podcasts.apple.com/us/podcast/viral-debates/id1590168397 --- Send in a voice message: https://podcasters.spotify.com/pod/show/viral-debates/message Support this podcast: https://podcasters.spotify.com/pod/show/viral-debates/support

The BC government under Premier David Eby has signaled new directions on protecting BC lands. They have committed to protect 30 percent of the province's land by 2030. This includes a mandate to work with Indigenous communities to create Indigenous Protected and Conserved Areas. We talk about the new commitment with Torrance Coste, National Campaign Director for the Wilderness Committee.

In this episode of the Epigenetics Podcast, we talked with Mary Gehring from MIT about her work on transgenerational inheritance and epigenetic imprinting in plants. Mary Gehring and her team are focusing on plant epigenetics and genetic imprinting in plants, studying DNA methylation in Arabidopsis. They have found significant differences in DNA methylation between the embryo and endosperm of plants, particularly in relation to imprinted genes. She also discusses their work on hydroxymethylcytosine (5-hmC) in Arabidopsis and the challenges of detecting and studying this epigenetic modification. Next, we discuss the regulatory circuit involving ROS1, a DNA glycosylase involved in demethylation, and its role in maintaining epigenetic homeostasis. The interview concludes with a discussion of CUT&RUN, which the lab has adapted for use in plants. Due to its low input requirements this method has been valuable in studying various plant tissues and has influenced Mary Gehring's research on imprinting in Arabidopsis endosperm.   References Gehring, M., Bubb, K. L., & Henikoff, S. (2009). Extensive demethylation of repetitive elements during seed development underlies gene imprinting. Science (New York, N.Y.), 324(5933), 1447–1451. https://doi.org/10.1126/science.1171609 Pignatta, D., Erdmann, R. M., Scheer, E., Picard, C. L., Bell, G. W., & Gehring, M. (2014). Natural epigenetic polymorphisms lead to intraspecific variation in Arabidopsis gene imprinting. eLife, 3, e03198. https://doi.org/10.7554/eLife.03198 Klosinska, M., Picard, C. L., & Gehring, M. (2016). Conserved imprinting associated with unique epigenetic signatures in the Arabidopsis genus. Nature plants, 2, 16145. https://doi.org/10.1038/nplants.2016.145 Zheng, X. Y., & Gehring, M. (2019). Low-input chromatin profiling in Arabidopsis endosperm using CUT&RUN. Plant reproduction, 32(1), 63–75. https://doi.org/10.1007/s00497-018-00358-1   Related Episodes The Role of Small RNAs in Transgenerational Inheritance in C. elegans (Oded Rechavi) Epigenetic Influence on Memory Formation and Inheritance (Isabelle Mansuy) The Epigenetics of Human Sperm Cells (Sarah Kimmins)   Contact Epigenetics Podcast on Twitter Epigenetics Podcast on Instagram Epigenetics Podcast on Mastodon Active Motif on Twitter Active Motif on LinkedIn Email: podcast@activemotif.com

Link to bioRxiv paper: http://biorxiv.org/cgi/content/short/2023.07.29.551032v1?rss=1 Authors: Sun, C., Zhou, C., Daneshvar, K., Kratkiewicz, A. J., Ben Saad, A., Hess, A., Chen, J. Y., Pondick, J. V., York, S. R., Li, W., Moran, S. P., Gentile, S., Ur Rahman, R., Li, Z., Sparks, R., Habboub, T., Kim, B.-M., Choi, M., Affo, S., Schwabe, R. F., Popov, Y. V., Mullen, A. C. Abstract: Background & Aims: Fibrosis is the common endpoint for all forms of chronic liver injury, and progression of fibrosis leads to the development of end-stage liver disease. Activation of hepatic stellate cells (HSCs) and their transdifferentiation to myofibroblasts results in the accumulation of the extracellular matrix (ECM) proteins that form the fibrotic scar. Long noncoding (lnc) RNAs regulate the activity of HSCs and may provide targets for fibrotic therapies. Methods: We identified lncRNA TILAM as expressed near COL1A1 in human HSCs and performed loss-of-function studies in human HSCs and liver organoids. Transcriptomic analysis of HSCs isolated from mice defined the murine ortholog of TILAM. We then generated Tilam-deficient GFP reporter mice and quantified fibrotic responses to carbon tetrachloride (CCl4) and choline-deficient L-amino acid defined high fat diet (CDA-HFD). Co-precipitation studies, mass spectrometry, and gene expression analyses identified protein partners of TILAM. Results: TILAM is conserved between human and mouse HSCs and regulates expression of ECM proteins, including collagen. Tilam is selectively induced in murine HSCs during the development of fibrosis in vivo. In both male and female mice, loss of Tilam results in reduced fibrosis in the setting of CCl4 and CDA-HFD injury models. TILAM interacts with promyelocytic leukemia protein (PML) to stabilize PML protein levels and promote the fibrotic activity of HSCs. Conclusion: TILAM is activated in HSCs and interacts with PML to drive the development of liver fibrosis. Depletion of TILAM may serve as a therapeutic approach to combat the development of end stage liver disease. Copy rights belong to original authors. Visit the link for more info Podcast created by Paper Player, LLC

Link to bioRxiv paper: http://biorxiv.org/cgi/content/short/2023.07.28.551061v1?rss=1 Authors: Keyport Kik, S., Christopher, D., Glauninger, H., Wong Hickernell, C., Bard, J. A. M., Ford, M., Sosnick, T. R., Drummond, D. A. Abstract: Cells must sense and respond to sudden maladaptive environmental changes--stresses--to survive and thrive. Across eukaryotes, stresses such as heat shock trigger conserved responses: growth arrest, a specific transcriptional response, and biomolecular condensation of protein and mRNA into structures known as stress granules under severe stress. The composition, formation mechanism, adaptive significance, and even evolutionary conservation of these condensed structures remain enigmatic. Here we provide an unprecedented view into stress-triggered condensation, its evolutionary conservation and tuning, and its integration into other well-studied aspects of the stress response. Using three morphologically near-identical budding yeast species adapted to different thermal environments and diverged by up to 100 million years, we show that proteome-scale biomolecular condensation is tuned to species-specific thermal niches, closely tracking corresponding growth and transcriptional responses. In each species, poly(A)-binding protein--a core marker of stress granules--condenses in isolation at species-specific temperatures, with conserved molecular features and conformational changes modulating condensation. From the ecological to the molecular scale, our results reveal previously unappreciated levels of evolutionary selection in the eukaryotic stress response, while establishing a rich, tractable system for further inquiry. Copy rights belong to original authors. Visit the link for more info Podcast created by Paper Player, LLC

Link to bioRxiv paper: http://biorxiv.org/cgi/content/short/2023.07.24.550375v1?rss=1 Authors: Willet, A. H., Turner, L. A., Park, J. S., Ren, L., Snider, C. E., Gould, K. L. Abstract: Phosphatidylinositol (PI)-4-phosphate (PI4P) is a lipid found at the plasma membrane (PM) and Golgi in cells from yeast to humans. PI4P is generated from PI by PI4-kinases and can be converted to PI-4,5-bisphosphate [PI(4,5)P2]. Schizosaccharomyces pombe have 2 essential PI4-kinases: Stt4 and Pik1. Stt4 localizes to the PM and its loss from the PM results in a decrease of PM PI4P and PI(4,5)P2. As a result, cells divide non-medially due to disrupted cytokinetic ring-PM anchoring. However, the localization and function of S. pombe Pik1 has not been thoroughly examined. Here, we found that Pik1 localizes exclusively to the trans-Golgi and is required for Golgi PI4P production. We determined that Ncs1 regulates Pik1, but unlike in other organisms, it is not required for Pik1 Golgi localization. When Pik1 function was disrupted, PM PI4P but not PI(4,5)P2 levels were reduced, a major difference with Stt4. We conclude that Stt4 is the chief enzyme responsible for producing the PI4P that generates PI(4,5)P2. Also, that cells with disrupted Pik1 do not divide asymmetrically highlights the specific importance of PM PI(4,5)P2 for cytokinetic ring-PM anchoring. Copy rights belong to original authors. Visit the link for more info Podcast created by Paper Player, LLC

Link to bioRxiv paper: http://biorxiv.org/cgi/content/short/2023.07.23.550229v1?rss=1 Authors: Manzer, K. M., Fromme, J. C. Abstract: Arf GTPases are central regulators of the Golgi complex, which serves as the nexus of membrane trafficking pathways in eukaryotic cells. Arf proteins recruit dozens of effectors to modify membranes, sort cargos, and create and tether transport vesicles, and are therefore essential for orchestrating Golgi trafficking. The regulation of Arf activity is controlled by the action of Arf-GEFs, which activate via nucleotide exchange, and Arf-GAPs, which inactivate via nucleotide hydrolysis. The localization dynamics of Arf GTPases and their Arf-GAPs during Golgi maturation have not been reported. Here we use the budding yeast model to examine the temporal localization of the Golgi Arf-GAPs. We also determine the mechanisms used by the Arf-GAP Age2 to localize to the Golgi. We find that the catalytic activity of Age2 and a conserved sequence in the unstructured C-terminal domain of Age2 are both required for Golgi localization. This sequence is predicted to form an amphipathic helix and mediates direct binding of Age2 to membranes in vitro. We also report the development of a probe for sensing active Arf1 in living cells and use this probe to characterize the temporal dynamics of Arf1 during Golgi maturation. Copy rights belong to original authors. Visit the link for more info Podcast created by Paper Player, LLC

Link to bioRxiv paper: http://biorxiv.org/cgi/content/short/2023.07.19.549681v1?rss=1 Authors: Gutierrez-Barragan, D., Ramirez, J. S. B., Panzeri, S., Xu, T., Gozzi, A. Abstract: Evolutionarily relevant networks have been previously described in several mammalian species using time-averaged analyses of fMRI time-series. However, fMRI network activity is highly dynamic and continually evolves over timescales of seconds. Whether the dynamic principles that govern intrinsic fMRI network fluctuations are conserved across mammalian species remains unclear. Using frame-wise clustering of fMRI time-series, we find that fMRI network dynamics in awake macaques and humans is characterized by recurrent transitions between a set of 4 dominant, neuroanatomically homologous fMRI coactivation modes (C-modes), three of which are also plausibly represented in the rodent brain. Importantly, in all species the identified C-modes exhibit species-invariant dynamic features, including intrinsic infraslow dynamics and preferred occurrence at specific phases of global fMRI signal fluctuations. Moreover, C-modes occurrence rates in awake humans, macaques and mice reflect temporal trajectories of least energy and predicts ranking of corresponding functional connectivity gradients. Our results reveal a set of species-invariant principles underlying the dynamic organization of fMRI networks in mammalian species, and offer novel opportunities to relate fMRI network findings across the phylogenetic tree. Copy rights belong to original authors. Visit the link for more info Podcast created by Paper Player, LLC

Link to bioRxiv paper: http://biorxiv.org/cgi/content/short/2023.07.17.549331v1?rss=1 Authors: Milioto, C., Carcole, M., Giblin, A., Coneys, R., Attrebi, O., Ahmed, M., Harris, S. S., Lee, B. I., Yang, M., Nirujogi, R. S., Biggs, D., Salomonsson, S., Zanovello, M., De Oliveira, P., Katona, E., Glaria, I., Mikheenko, A., Geary, B., Udine, E., Vaizoglu, D., Rademakers, R., van Blitterswijk, M., Devoy, A., Hong, S., Partridge, L., Fratta, P., Alessi, D., Davies, B., Busche, M. A., Greensmith, L., Fisher, E. M., Isaacs, A. M. Abstract: A GGGGCC repeat expansion in C9orf72 is the most common genetic cause of ALS and FTD (C9ALS/FTD). The presence of dipeptide repeat (DPR) proteins, generated by translation of the expanded repeat, is a major pathogenic feature of C9ALS/FTD pathology, but their most relevant effects in a physiological context are not known. Here, we generated C9orf72 DPR knock-in mouse models characterised by physiological expression of 400 codon-optimised polyGR or polyPR repeats, and heterozygous C9orf72 reduction. (GR)400 and (PR)400 knock-in mice exhibit cortical neuronal hyperexcitability, age-dependent spinal motor neuron loss and progressive motor dysfunction, showing that they recapitulate key features of C9FTD/ALS. Quantitative proteomics revealed an increase in extracellular matrix (ECM) proteins in (GR)400 and (PR)400 spinal cord, with the collagen COL6A1 the most increased protein. This signature of increased ECM proteins was also present in C9ALS patient iPSC-motor neurons indicating it is a conserved feature of C9ALS/FTD. TGF-{beta}1 was one of the top predicted regulators of this ECM signature and polyGR expression in human iPSC-neurons was sufficient to induce TGF-{beta}1 followed by COL6A1, indicating TGF-{beta}1 is one driver of the ECM signature. Knockdown of the TGF-{beta}1 or COL6A1 orthologue in Drosophila dramatically and specifically exacerbated neurodegeneration in polyGR flies, showing that TGF-{beta}1 and COL6A1 protect against polyGR toxicity. Altogether, our physiological C9orf72 DPR knock-in mice have revealed a neuroprotective and conserved ECM signature in C9FTD/ALS. Copy rights belong to original authors. Visit the link for more info Podcast created by Paper Player, LLC

Bo Zhao is a 2nd year PhD student in computer science at UCSD, advised by Rose Yu. Her research focuses on deep learning theory and optimization, with a recent emphasis on the parameter space and dynamics of learning. Today Bo joined us to talk about her recent paper, "Symmetries, Flat Minima, and the Conserved Quantities of Gradient Flow", which was joint work at ICLR with Iordan Ganev, as well as co-authors Robin Walters, Rose Yu, and Nima Dehmamy. This is a really interesting paper which takes an algebraic approach to a problem typically only studied analytically. Bo gave a phenomenal presentation and then we had a really nice discussion with a variety of technical questions. We enjoyed this one a lot and we hope you do too!

Link to bioRxiv paper: http://biorxiv.org/cgi/content/short/2023.06.27.546757v1?rss=1 Authors: Srinivasan, S., Daste, S., Modi, M., Turner, G., Fleischmann, A., Navlakha, S. Abstract: Sparse coding is thought to improve discrimination of sensory stimuli by reducing overlap between their representations. Two factors, however, can offset sparse coding's advantages. Similar sensory stimuli have significant overlap, and responses vary across trials. To elucidate the effect of these two factors, we analyzed odor responses in the fly and mouse olfactory regions implicated in learning and discrimination --- the Mushroom Body (MB) and the Piriform Cortex (PCx). In both species, we show that neuronal responses fall along a continuum from extremely reliable across trials to extremely variable or stochastic. Computationally, we show that the range of observed variability arises from probabilistic synapses in inhibitory feedback connections within central circuits rather than sensory noise, as is traditionally assumed. We propose this coding scheme to be advantageous for coarse- and fine-odor discrimination. More reliable cells enable quick discrimination between dissimilar odors. For similar odors, however, these cells overlap, and do not provide distinguishing information. By contrast, more unreliable cells are decorrelated for similar odors, providing distinguishing information, though this requires extended training with more trials. Overall, we have uncovered a stochastic coding scheme that is conserved in vertebrates and invertebrates, and we identify a candidate mechanism, based on variability in a winner-take-all inhibitory circuit, that improves discrimination with training. Copy rights belong to original authors. Visit the link for more info Podcast created by Paper Player, LLC

We catch up with the manager of the Kluscap Indigenous Protected and Conserved area fresh from a bioblitz at the site, to inventory some of the flora and fauna.

This is our second of a two part series all about “drying off” lactating dairy cows. Part One of this two-part series (Episode 30) covered off the basics of why the cow and her udder need a dry period to rest and recuperate in preparation for a new lactation. What a “good” dry off process might look like was discussed, as well as the impact of once-a-day milking before dry off for cows that are still producing a lot of milk in late lactation. In this, Part Two of the two-part series about drying off dairy cows, we explore the role for nutrition before, through and after the dry off process. We'll cover different ways to reduce the intake of energy and other nutrients for cows during dry off, with the aim to make the process as successful as we can - for both the cow but also for you and your business. Below hopefully will help you find the content if you've not got time to listen in to the whole podcast. Enjoy!  3.00 Introduction and overview of this podcast 4.50 Combining nutritional  manipulation and milking frequency for high producing cows at dry off 5.35 Nutritional strategies to help dry cows off – things to consider 7.35 Making decisions around drying off – how much milk are your cows producing? 10.20 Nutritional concepts to help drop milk production before dry off 13.10 Concentrate (grains, meals) feeding before dry off 16.00 Total amount of feed on offer and/or reducing nutrient density of feeds through dry off 21.35 Unintended consequences during dry off; condition loss and immunosuppression 29.50 Importance of adequate trace mineral status through dry off 31.15 Reducing dietary protein intake as a potential option to help with dry off 42.40 Planning ahead for nutritional approaches to dry off – starting the year before 49.20 Conserved feeds for dry off 54.30 Specific points around use of high rates of maize silage for drying off 56.10 Provision of ample, top quality tasty drinking water for cows through dry off – an essential part of the dry off process  

Link to bioRxiv paper: http://biorxiv.org/cgi/content/short/2023.05.04.539419v1?rss=1 Authors: Zhang, X., Eladawi, M. A., Ryan, W. G., Fan, X., Prevoznik, S., Devale, T., Ramnani, B., Krishnamurthy, M. A., Sibille, E., McCullumsmith, R., Tomoda, T., Shukla, R. Abstract: The underlying biological mechanisms that contribute to the heterogeneity of major depressive disorder (MDD) presentation remain poorly understood, highlighting the need for a conceptual framework that can explain this variability and bridge the gap between animal models and clinical endpoints. Here, we hypothesize that comparative analysis of molecular data from different experimental systems of chronic stress and MDD has the potential to provide insight into these mechanisms and address this gap. Thus, we compared transcriptomic profiles of brain tissue from postmortem MDD subjects and from mice exposed to chronic variable stress (CVS) to identify orthologous genes. Ribosomal protein genes (RPGs) were downregulated, and associated RP-pseudogenes were upregulated in both conditions. Analysis across independent cohorts confirmed that this dysregulation was specific to the prefrontal cortex of both species. A seeded gene co-expression analysis using altered RPGs common between the MDD and CVS groups revealed that downregulated RPGs homeostatically regulated the synaptic changes in both groups through a RP-pseudogene-driven mechanism. In-vitro and in-silico analysis further demonstrated that the inverse RPG/RP-pseudogene association was a glucocorticoid-driven endocrine response to stress that was reversed during remission from MDD. This study provides the first evidence that ribosomal dysregulation during stress is a conserved phenotype in human MDD and CVS exposed mouse. Our results establish a foundation for the hypothesis that stress-induced alterations in RPGs and, consequently, ribosomes contribute to the synaptic dysregulation underlying MDD and chronic stress-related mood disorders. We discuss a ribosome-dependent mechanism for the variable presentations of depression and other mood disorders. Copy rights belong to original authors. Visit the link for more info Podcast created by Paper Player, LLC

Lead Story: The conserved endocannabinoid anandamide modulates olfactory sensitivity to induce hedonic feeding in C. elegans  Current Biology Laboratory worm Caenorhabditis elegans apparently gets the ‘munchies' when exposed to cannabis. After soaking in an endocannabinoid bath, worms preferred to eat nutrient-rich, rather than nutrient-poor, bacteria. They fed for longer than worms not exposed to endocannabinoid or worms without working endocannabinoid receptors. This shared trait points to the deep evolutionary origin of cannabinoid receptors and behaviors influenced by the molecules. Read this issue of the ASAM Weekly Subscribe to the ASAM Weekly Visit ASAM

Link to bioRxiv paper: http://biorxiv.org/cgi/content/short/2023.04.24.538157v1?rss=1 Authors: Ling, D., Hanson Moss, E., Smith, C. L., Kroeger, R., Reimer, J. L., Raman, B., Arenkiel, B. R. Abstract: Interpreting chemical information and translating it into ethologically relevant output is a common challenge of olfactory systems across species. Are computations performed by olfactory circuits conserved across species to overcome these common challenges? To understand this, we compared odor responses in the locust antennal lobe (AL) and mouse olfactory bulb (OB). We found that odors activated nearly mutually exclusive neural ensembles during stimulus presentation (ON response) and after stimulus termination (OFF response). Strikingly, ON and OFF responses evoked by a single odor were anticorrelated with each other. Inverted OFF responses enhanced contrast between odors experienced close together in time. Notably, OFF responses persisted long after odor termination in both AL and OB networks, indicating a form of short-term memory. Taken together, our results reveal key neurodynamic features underlying olfactory computations that are conserved across insect and mammalian olfactory systems. Copy rights belong to original authors. Visit the link for more info Podcast created by Paper Player, LLC

Our landowner partners represent the heart and soul of the Rangeland Trust. Because of their admirable decisions to conserve their ranches, California will always have places available for local food to be grown, air to be cleansed, freshwater to flow, wildlife to roam, and spectacular viewsheds to be admired. In this episode, Michael is joined by landowner partner, Alisha Taff. Alisha is the owner of the Rock Front Ranch in the Cuyama Valley in Santa Barbara and San Luis Obispo Counties. Conserved in 2020, the 300-acre Rock Front Ranch marked the first time in Rangeland Trust history that conservation was funded entirely by contributions from the community. Tune in to hear Alisha talk about current happenings on the ranch, her work in regenerative agriculture, and what it means to her to see her beloved ranch forever protected thanks to the more than 200 donors that rallied behind her to achieve conservation.

Link to bioRxiv paper: http://biorxiv.org/cgi/content/short/2023.03.20.533538v1?rss=1 Authors: Starkey, J., Hageter, J., Kozol, R., Emmerich, K., Mumm, J. S., Duboue, E. R., Horstick, E. J. Abstract: Brain laterality is a prominent feature in Bilateria, where neural functions are favored in a single brain hemisphere. These hemispheric specializations are thought to improve behavioral performance and are commonly observed as sensory or motor asymmetries, such as handedness in humans. Despite its prevalence, our understanding of the neural and molecular substrates instructing functional lateralization is limited. Moreover, how functional lateralization is selected for or modulated throughout evolution is poorly understood. While comparative approaches offer a powerful tool for addressing this question, a major obstacle has been the lack of a conserved asymmetric behavior in genetically tractable organisms. Previously, we described a robust motor asymmetry in larval zebrafish. Following the loss of illumination, individuals show a persistent turning bias that is associated with search pattern behavior with underlying functional lateralization in the thalamus. This behavior permits a simple yet robust assay that can be used to address fundamental principles underlying lateralization in the brain across taxa. Here, we take a comparative approach and show that motor asymmetry is conserved across diverse larval teleost species, which have diverged over the past 200 million years. Using a combination of transgenic tools, ablation, and enucleation, we show that teleosts exhibit two distinct forms of motor asymmetry, vision-dependent and -independent. These asymmetries are directionally uncorrelated, yet dependent on the same subset of thalamic neurons. Lastly, we leverage Astyanax sighted and blind morphs, which show that fish with evolutionarily derived blindness lack both retinal-dependent and -independent motor asymmetries, while their sighted surface conspecifics retained both forms. Our data implicate that overlapping sensory systems and neuronal substrates drive functional lateralization in a vertebrate brain that are likely targets for selective modulation during evolution. Copy rights belong to original authors. Visit the link for more info Podcast created by Paper Player, LLC

Link to bioRxiv paper: http://biorxiv.org/cgi/content/short/2023.03.20.533401v1?rss=1 Authors: Rachmian, N., Medina, S., Cherqui, U., Akiva, H., Deitch, D., Edilbi, D., Croese, T., Salame, T. M., Peralta Ramos, J. M., Cahalon, L., Krizhanovsky, V., Schwartz, M. Abstract: Dementia in general, and Alzheimer's disease (AD) in particular, are age-related diseases (1,2). AD is associated with multiple causative factors (3,4), among which local brain inflammation plays a significant role (5). Microglia, the brain-resident immune cells, are activated along the disease course (6,7). Yet, their contribution to the disease progression is still controversial. Here, using high-throughput mass cytometry for microglial immuno-phenotyping, we identified accumulation of senescent microglia in several pathologies associated with cognitive decline. These senescent microglia have a unique profile conserved across the multiple conditions investigated, including aging, mouse models of amyloidosis, and tauopathy. Moreover, we found that the expression of markers of senescence correlates with levels of TREM2, whose polymorphism was identified by GWAS as an AD risk factor (8,9). A TREM2-null AD mouse model showed lower levels of senescent microglia, relative to TREM2-intact AD mice. Senolysis using the drug ABT-73710,11 in an AD mouse model reduced the abundance of TREM2-senescent microglia without affecting levels of TREM2-dependent activated microglia, ameliorated cognitive deficits, and reduced brain inflammation. These results reveal the unexpected contribution of TREM2 to accumulation of senescent microglia in AD pathology, an effect that must be considered when targeting TREM2 as a therapeutic approach. Copy rights belong to original authors. Visit the link for more info Podcast created by Paper Player, LLC

https://psychiatry.dev/wp-content/uploads/speaker/post-12337.mp3?cb=1679327338.mp3 Playback speed: 0.8x 1x 1.3x 1.6x 2x Download: Evolutionarily conserved regulators of tau identify targets for new therapies – PubMed Jiyoen Kim et al. Neuron. 2023. Tauopathies are neurodegenerative diseasesFull EntryEvolutionarily conserved regulators of tau identify targets for new therapies – PubMed

Link to bioRxiv paper: http://biorxiv.org/cgi/content/short/2023.03.01.530679v1?rss=1 Authors: Stewart, R. G., Camacena, M., Copits, B. A., Sack, J. T. Abstract: The distinct organization of Kv2 voltage-gated potassium channels on and near the cell body of brain neurons enables their regulation of action potentials and specialized membrane contact sites. Somatosensory neurons have a pseudo unipolar morphology that allows transmitted action potentials to bypass the cell body. Kv2 channels regulate action potentials in somatosensory neurons, yet little is known about where Kv2 channels are located. Here we define the cellular and subcellular localization of the Kv2 paralogs, Kv2.1 and Kv2.2, in dorsal root ganglia (DRG) somatosensory neurons with a panel of antibodies, cell markers, and genetically modified mice. We find that relative to spinal cord neurons, DRG neurons have similar levels of detectable Kv2.1, and higher levels of Kv2.2. In older mice, detectable Kv2.2 remains similar while detectable Kv2.1 decreases. Both Kv2 subtypes adopt clustered subcellular patterns that are distinct from central neurons. Kv2.2 is distinct in being found at juxtaparanodes and paranodes of myelinated axons. Most DRG neurons co-express Kv2.1 and Kv2.2, although neuron subpopulations show preferential expression of Kv2.1 or Kv2.2. We find that Kv2 protein expression and subcellular localization is similar between mouse and human DRG neurons. We conclude that the organization of both Kv2 channels is consistent with physiological roles in the somata and stem axons of DRG neurons. The general prevalence of Kv2.2 in DRG as compared to central neurons and the enrichment of Kv2.2 relative to detectable Kv2.1, in older mice, proprioceptors, and myelinated axons suggest more widespread roles for Kv2.2 in DRG neurons. Copy rights belong to original authors. Visit the link for more info Podcast created by Paper Player, LLC

Link to bioRxiv paper: http://biorxiv.org/cgi/content/short/2023.03.01.529730v1?rss=1 Authors: Velle, K. B., Garner, R. M., Beckford, T. K., Weeda, M., Liu, C., Kennard, A. S., Edwards, M., Fritz-Laylin, L. K. Abstract: Controlling intracellular osmolarity is essential to all cellular life. Cells that live in hypo-osmotic environments like freshwater must constantly battle water influx to avoid swelling until they burst. Many eukaryotic cells use contractile vacuoles to collect excess water from the cytosol and pump it out of the cell. Although contractile vacuoles are essential to many species, including important pathogens, the mechanisms that control their dynamics remain unclear. To identify basic principles governing contractile vacuole function, here we investigate the molecular mechanisms of two species with distinct vacuolar morphologies from different eukaryotic lineages - the discoban Naegleria gruberi, and the amoebozoan slime mold Dictyostelium discoideum. Using quantitative cell biology we find that, although these species respond differently to osmotic challenges, they both use actin for osmoregulation, as well as vacuolar-type proton pumps to fill contractile vacuoles. We also use analytical modeling to show that cytoplasmic pressure is sufficient to drive water out of contractile vacuoles in these species, similar to findings from the alveolate Paramecium multimicronucleatum. Because these three lineages diverged well over a billion years ago, we propose that this represents an ancient eukaryotic mechanism of osmoregulation. Copy rights belong to original authors. Visit the link for more info Podcast created by Paper Player, LLC

Link to bioRxiv paper: http://biorxiv.org/cgi/content/short/2023.02.27.530319v1?rss=1 Authors: Swords, S. B., Jia, N., Norris, A., Modi, J., Cai, Q., Grant, B. D. Abstract: Autophagosomes fuse with lysosomes, forming autolysosomes that degrade engulfed cargo. To maintain lysosomal capacity, autolysosome reformation (ALR) must regenerate lysosomes from autolysosomes using a membrane tubule-based process. Maintaining lysosomal capacity is required to maintain proteostasis and cellular health, especially in neurons where lysosomal dysfunction has been repeatedly implicated in neurodegenerative disease. Cell biological studies have linked the DNA-J domain Hsc70 co-chaperone RME-8/DNAJC13 to endosomal coat protein regulation, while human genetics studies have linked RME-8/DNAJC13 to neurological disease, including Parkinsonism and Essential Tremor. We report new analysis of the requirements for the RME-8/DNAJC13 protein in neurons, focusing on C. elegans mechanosensory neurons in the intact animal, and in primary mouse cortical neurons in culture. We find that loss of RME-8/DNAJC13 in both systems results in accumulation of grossly elongated autolysosomal tubules. Further C. elegans analysis revealed a similar autolysosome tubule accumulation defect in mutants known to be required for ALR in mammals, including bec-1/beclin and vps-15/PIK3R4/p150 that regulate type-III PI3-kinase VPS-34, and dyn-1/dynamin that severs ALR tubules. Clathrin is also an important ALR regulator implicated in autolysosome tubule formation and release. In C. elegans we found that loss of RME-8 causes severe depletion of clathrin from neuronal autolysosomes, a phenotype shared with bec-1 and vps-15 mutants. We conclude that RME-8/DNAJC13 plays a conserved but previously unrecognized role in autolysosome reformation, likely affecting ALR tubule initiation and/or severing. Additionally, in both systems, we found that loss of RME-8/DNAJC13 appeared to reduce autophagic flux, suggesting feedback regulation from ALR to autophagy. Our results connecting RME-8/DNAJC13 to ALR and autophagy provide a potential mechanism by which RME-8/DNAJC13 could influence neuronal health and the progression of neurodegenerative disease. Copy rights belong to original authors. Visit the link for more info Podcast created by Paper Player, LLC

https://psychiatry.dev/wp-content/uploads/speaker/post-11991.mp3?cb=1677242315.mp3 Playback speed: 0.8x 1x 1.3x 1.6x 2x Download: Conserved reduction of m6A RNA modifications during aging and neurodegeneration is linked to changes in synaptic transcripts – PubMed Ricardo Castro-Hernández etFull EntryConserved reduction of m6A RNA modifications during aging and neurodegeneration is linked to changes in synaptic transcripts – PubMed

Link to bioRxiv paper: http://biorxiv.org/cgi/content/short/2023.01.27.525835v1?rss=1 Authors: Yamaguchi, A., Peltier, M. Abstract: Across phyla, species-specific vocalizations are used by males to attract females. Functional analyses of the neural circuitry underlying behavior have been difficult, particularly in vertebrates. However, using an ex vivo brain preparation that produces fictive vocalizations, we previously identified anatomically distinct fast and slow central pattern generators (CPGs) that drive the fast and slow clicks of male courtship calls in male African clawed frogs, Xenopus laevis. To gain insight into the evolution of neural circuits underlying courtship calls, we extended this approach to four additional species. Here, we show that although the exact rate and duration of the clicks are unique to each species, fast and slow CPGs identified in male X. laevis are conserved across species. Further, we show that the development of fast CPGs depends on testosterone in a species-specific manner: testosterone facilitates the development of fast CPGs in a species with a courtship call containing fast clicks, but not in a species with a courtship call made entirely of slow clicks. Finally, we showed that, unlike other vestigial neural circuits that remain latent, the fast CPGs are not inherited by all species; rather, they are possessed only by the species that produce fast clicks. The results suggest that species specific calls of the genus Xenopus have evolved by utilizing conserved fast or slow CPGs that are broadly tuned to generate fast or slow trains of clicks, the development of which appear to be regulated by a strategic expression of testosterone receptors in the brain of each species. Copy rights belong to original authors. Visit the link for more info Podcast created by Paper Player, LLC

In this episode we talk with Missouri State Senator Bill Eigle. Bill is a veteran, small business owner and a conservative. He and his wife, Amanda, have long ties to St. Charles County. He has recently announched that he is running for Governor in Missouri in 2024. Check out his website www.LetsGoMo.org to learn more about what he is fighting for!  @tony.frisella @jessica.l.rider Brace For Impact: https://brace-for-impact-46.myshopify.com/products/test-brew-for-impact-buy-now USE CODE TONY10 FOR 10% OFF YOUR PURCHASE!

The BC government under Premier David Eby has signaled new directions on protecting BC lands. They have committed to protect 30 per cent of the province's land by 2030. This includes a mandate to work with Indigenous communities to create Indigenous Protected and Conserved Areas. We talk about the new commitment with Torrance Coste, National Campaign Director for the Wilderness Committee.

The evidence is indisputable, the areas occupied and managed by Indigenous Peoples span 24% of the global terrestrial surface, and they are home to 80% of the world's remaining biodiversity. Cultural Survival attended COP15 in Montreal, Canada, and spoke to some of the delegates Produced by Bryan Bicxul ((Maya Tz'utujil)) Edited by Shaldon Ferris (Khoisan) Interviewee: Giovanni Reyes (Kankaney Igorot) Image from ICCA Consortium "Lights in the forest by Ziibiwan, Used with Permission "Burn your village to the ground", by The Halluci Nation, used with permission

This Day in Maine for Tuesday, August 30th, 2022.

Daniel and Jorge talk about why the Universe seems to follow rules, and celebrate the birthday of the woman who revealed the this deep truth.   See omnystudio.com/listener for privacy information.

Matthew Continetti's new book The Right: The Hundred-Year War for American Conservatism has instigated a vigorous conversation around the best way to understand the historical phenomenon of modern conservatism in the United States.  Returning guest Avi Woolf joins Josh for a discussion on what Continetti's depiction gets right and not-so-right about American conservatism, what has conservatism conserved, and what ought conservatism to conserve in the future.   About Avi Woolf   Avi Woolf is a writer, editor, translator, and podcaster whose work has been published in Arc Digital, Commentary, National Review, The Bulwark, Ordinary Times, and The Dispatch.  He is chief editor of the online Medium publication Conservative Pathways, and he—in his words—"hopes to help forge a path for a conservatism which is relevant for the 21st century while not abandoning the best of past wisdom.”   Avi has been a guest on the show several times prior: the first in which he explored the need for conservatism to find a way to appeal to people who live in urban areas in Episode 26 – Urban Conservatism, the second in which he mulled over the love/hate relationship the Right has long had with institutions of higher education in Episode 49 – God and the Speechless at Yale, and, finally, where he considered what is America and what does it mean to be an American in Episode 87 – E Pluribus Unum with Avi Woolf.   Avi hosts his own podcast entitled Avi's Conversational Corner, a podcast on culture, history, and politics in a broad perspective. You can find Avi on Twitter @AviWoolf   Introducing the Are We Right? Podcast   If you like Saving Elephants you'll love the new podcast Are We Right? featuring Saving Elephants host Josh Lewis along with three other co-hosts: Cal Davenport, Brooke Medina, and Calvin Moore. Cal, Josh Brooke, and Calvin debate a wide range of topics from politics to religion to culture and invite the audience to weigh in on whether or not they're right. You can find the podcast on iTunes, Spotify, Stitcher, or wherever you listen, find us on Twitter @ TheAWRPodcast, and email us at arewerightpodcast@gmail.com.  

A top aid for Mark Meadows testified today in the January 6th hearings. Meanwhile, the left is losing their mind on Elon Musk.

A top aid for Mark Meadows testified today in the January 6th hearings. Meanwhile, the left is losing their mind on Elon Musk.

A collaborative discussion with Dr. Perry Cabot of Colorado State University, Aaron Derwingson of The Nature Conservancy's Colorado River Program, and Paul Bruchez, Farmer and Member of the Colorado Water Conservation Board discuss their large-scale depletion accounting pilot project. We discuss the role of Open ET satellite imaging to determine actual evaporative losses from crops as well as on-going on-farm mitigation and operational studies to promote farm health in the face of water shortage and drought. This podcast is brought to you by the law firm of Clyde Snow and Sessions, based in Salt Lake City with offices in Oregon and California. For over 65 years Clyde Snow has represented clients throughout the West. Clyde Snow - Serious About Solutions. Nothing said in this podcast should be taken as providing legal advice or as establishing an attorney-client relationship with you or anyone else. This podcast was produced by MacKenzie Nickles. Find Ripple Effect on iTunes, Spotify, or wherever you get your podcasts. Thank you for listening!

T-shirts & more are finally available!! http://tee.pub/lic/BAMG What are Restored vs. Conserved comic books and why should you know the difference? John & Richard break it down and discuss whether the dreaded purple label is still the kiss of death for you comics or not! Also, our Hot Book of the Week is a legendary crossover event, the 25 Year Rule features an early X-Men variant cover, and our Underrated Books of the Week include Rogue and Ms. Marvel! Bronze and Modern Gods is the channel dedicated to the Bronze, Copper and Modern Ages of comics and comic book collecting! Follow us on Facebook - https://www.facebook.com/BronzeAndModernGods Follow us on Instagram - https://www.instagram.com/bronzeandmoderngods #comics #comicbooks #comiccollecting --- Support this podcast: https://anchor.fm/bronzeandmoderngods/support

Chronobiology is the study of biological rhythms. The human circadian system is a biological process known to regulate the sleeping and waking cycle (circadian rhythm; CR). Components of the circadian system are known as ​​clock genes. Clock genes generate daily oscillations of gene expression and interact as an intricate network to influence biological processes in organisms, tissues and cells. This system is primarily regulated by Earth's day and night cycles (light and darkness), though it can be affected by other factors, including nutrition, cellular devices, stress, illness, jet lag, and aging. “It is well established that aging interferes with the regulation of the circadian system, which, in return, contributes to the manifestation and progression of aging-related diseases (reviewed in [4, 5]).” Across an organism's lifespan, changes in circadian rhythm take place. These changes can cause aging-related diseases to become more prevalent. Studies have also shown that age-independent alterations in the circadian system can result in premature aging. This interrelation between aging and CR means that aging may play a role in the circadian system and that the circadian system may play a role in aging. However, researchers have not yet fully illuminated the impact of aging-related circadian system changes on healthy organs and tissues. “Whether aging-related changes of the circadian system's regulation follow a conserved pattern across different species and tissues, hence representing a common driving force of aging, is unclear.” In an effort to identify circadian rhythm regulatory patterns over the course of aging, researchers—from Friedrich Schiller University Jena, FLI Leibniz Institute for Age Research, Jena University Hospital, German Center for Integrative Biodiversity Research, and European Virus Bioinformatics Center—performed inter-species and inter-organ transcriptional analyses. The research paper was published in December of 2021 as the cover of Aging (Aging-US) Volume 12, Issue 24, and entitled, “Age-dependent expression changes of circadian system-related genes reveal a potentially conserved link to aging.” Full blog - https://www.impactjournals.com/journals/blog/aging/aging-and-circadian-rhythm-does-a-conserved-link-exist/ Sign up for free Altmetric alerts about this article - https://oncotarget.altmetric.com/details/email_updates?id=10.18632%2Foncotarget.203788 DOI - https://doi.org/10.18632/aging.203788 Full Text - https://www.aging-us.com/article/203788/text Correspondence to: Emanuel Barth email: emanuel.barth@uni-jena.de Keywords: aging, circadian clock system, circadian rhythm, inter-species comparison, longevity, RNA-Seq About Aging-US Launched in 2009, Aging-US publishes papers of general interest and biological significance in all fields of aging research and age-related diseases, including cancer—and now, with a special focus on COVID-19 vulnerability as an age-dependent syndrome. Topics in Aging-US go beyond traditional gerontology, including, but not limited to, cellular and molecular biology, human age-related diseases, pathology in model organisms, signal transduction pathways (e.g., p53, sirtuins, and PI-3K/AKT/mTOR, among others), and approaches to modulating these signaling pathways. Please visit our website at http://www.Aging-US.com​​ or connect with us on: SoundCloud - https://soundcloud.com/Aging-Us Facebook - https://www.facebook.com/AgingUS/ Twitter - https://twitter.com/AgingJrnl Instagram - https://www.instagram.com/agingjrnl/ YouTube - https://www.youtube.com/agingus​ LinkedIn - https://www.linkedin.com/company/aging/ Pinterest - https://www.pinterest.com/AgingUS/ Aging-US is published by Impact Journals, LLC please visit http://www.ImpactJournals.com​​ or connect with @ImpactJrnls Media Contact 18009220957 MEDIA@IMPACTJOURNALS.COM

Some more information on Eli Enns and Dr. Courtney Mason and their work with the Canadian Mountain Network: Pacific Indigenous Protected and Conserved Areas Knowledge HubDr. Courtney Mason's bio For more information on the podcast and the Canadian Mountain Network, head to canadianmountainnetwork.ca SUBSCRIBE:Google PodcastsApple Podcasts FOLLOW:Website: canadianmountainnetwork.ca FacebookInstagramLinkedInTwitter