Podcasts about biomolecular

In-form-ation - broken down. We've been lied to all these years about what are bodies are and how they work. The new science of quantum biology turns everything we thought we knew on its head.Order my new book, Mind Medicine

Send us a textThis week we spoke to Dr. Colm Collins! Dr. Collins is an Associate Professor at the Conway Institute of Biomolecular and Biomedical Research at University College Dublin. He shares his journey from the world of pharmacology to pioneering research in inflammatory bowel disease (IBD). You'll learn about the innovative approaches his team is exploring to revolutionize treatment options for IBD patients. With a blend of humor and expertise, Dr. Collins offers a rare glimpse into the challenges and triumphs of translating scientific breakthroughs into real-world health solutions.Our conversation unravels the intricate relationship between the immune system and gut bacteria, as Dr. Collins explains how retinoic acid and microRNAs play crucial roles in managing IBD. We delve into the promising possibilities of replacing lost proteins and the therapeutic potential of cannabinoids, exploring their implications on both the immune system and the digestive tract. Amidst the science, we tackle the ethical and legal complexities of cannabis research, particularly in adolescents, as Dr. Collins shares his experiences navigating these challenges with integrity and humor.Join us for an enlightening discussion that balances serious scientific inquiry with light-hearted anecdotes, as Dr. Collins recounts his experiences in Colorado and discusses the future of IBD treatment. From the nuances of cannabis use in managing IBD symptoms to the exciting potential of selective human receptor-modifying peptides, this episode promises to expand your understanding and offer hope for more effective therapies on the horizon. Plus, enjoy a humorous account of altitude adaptation and its quirky effects on newcomers and the unexpected twists in cannabis research funding.Links: Journal article: Manipulation of the Endocannabinoid System in Colitis: A Comprehensive ReviewJournal article: Adherence, Safety, and Effectiveness of Medical Cannabis and Epidemiological Characteristics of the Patient Population: A Prospective StudyInformation on medical cannabis and IBD: Crohn's & Colitis Foundation- USAResearch funding opportunities- Crohn's & Colitis Foundation- USALet's get social!!Follow us on Instagram!Follow us on Facebook!Follow us on Twitter!

Guest: Colm Collins, Assistant Professor at the School of Biomolecular and Biomedical Sciences in UCD, and Conway Investigator.

Guest: Colm Collins, Assistant Professor at the School of Biomolecular and Biomedical Sciences in UCD, and Conway Investigator.

Dr. Shana Kelley is the President of the Chan Zuckerberg Biohub Chicago and the Neena B. Schwartz Professor of Chemistry and Biomedical Engineering at Northwestern University. The Kelley research group works in a variety of areas spanning bio analytical technology development and has pioneered new methods for tracking molecular and cellular analytes with unprecedented sensitivity. She talks about developing DNA-based reagentless biosensors and commercializing new technologies.

Andy Galpin is a professor of kinesiology at California State University, Fullerton. He is the Co-Director of the Center for Sport Performance and Founder/Director of the Biochemistry and Molecular Exercise Physiology Laboratory. He is a Human Performance scientist with a PhD in Human Bioenergetics and has collaborated with top-tier athletes across various domains including the UFC, MLB, NBA, PGA, NFL, Boxing, Olympics, Military, and Special Forces. Additionally, he co-founded Vitality Blueprint, Absolute Rest, BioMolecular Athlete, and RAPID Health & Performance and will be the host of the upcoming Perform with Dr. Andy Galpin podcast, set to launch this Summer 2024. To learn more about Andy, follow him on Instagram at @drandygalpin and check out andygalpin.com. Thank you to our sponsors. Please support them: SIG SAUER: https://www.sigsauer.com/ MTN OPS: Checkout MTN OPS x MTNTOUGH Co-Branded Hydrate Flavor: ⁠https://mtn-ops.sjv.io/5gJbz1⁠ TURTLEBOX Audio: Use promo code TOUGH for a free Turtlebox hat with purchase of a Gen2 speaker. https://turtleboxaudio.com/products/turtlebox-speaker-gen-2 ---- What is MTNTOUGH? MTNTOUGH is The #1 Fitness App Trusted By The Dedicated Our premier functional fitness programming is conveniently packaged for hunters, first responders, military, and mountain athletes. Train at home, at the gym, or on the go. Since 2016, MTNTOUGH has been dedicated to helping individuals achieve their personal goals by creating a foundation for physical and mental toughness. The brand's best-in-class programs are developed, tested, and proven by former Navy SEALs, Army Rangers, and renowned physical trainers. MTNTOUGH+ programs are used by elite groups and operators, including special ops forces, wildland firefighters, backcountry hunters, professional mountain athletes, and more. The MTNTOUGH fitness lab is headquartered in Bozeman, Montana, surrounded by some of the world's top mountain athletes. Chapters: 00:00:00 - Taking Responsibility for Your Own Success 00:05:33 - Enhancing Human Performance 00:10:07 - Making Science Accessible on Multiple Platforms 00:14:20 - Carving My Own Path in the Fitness Industry 00:18:30 - Taking Risks and Pursuing Autonomy 00:22:52 - Carving our Path 00:27:45 - The Mind-Body Connection in Coaching Programs 00:32:18 - Mental Performance in Sports 00:36:34 - Finding Focus in Stressful Situations 00:41:37 - Fighting through Chaos 00:45:50 - Mental Rehearsal and Conditioning Strategies 00:49:44 - The Importance of Controlling What You Can Control 00:54:49 - Maximizing Performance and Overcoming Constraints 00:59:08 - Optimizing Human Performance 01:03:10 - Remove Constraints for Peak Performance in Physiology 01:07:56 - Blood Markers and Optimal Performance 01:12:33 - Identifying Clinical Disorders 01:16:55 - Common Health Issues 01:21:13 - Effective Supplements for Performance 01:25:45 - Top Supplements for High Performance 01:30:21 - Check out Dr. Andy Galpin on Instagram and his upcoming podcast #humanperformance #andygalpin #mtntough #strengthtraining #BioMolecular #athlete #fitness #functionalfitness #weighttraining #motivation #performance #performancetraining #hypertrophy #sciencepodcast

Chief of the Biomolecular Measurement Division at the Material Measurement Laboratory, NIST. With a distinguished career in analytical chemistry and extensive experience in biochemical sensing and bioprocess measurements, Michael leads critical initiatives to advance biotechnology and healthcare.   In this episode, we delve into the pivotal role of NIST as a non-regulatory agency within the Department of Commerce, highlighting its profound impact on measurement science, gene therapy, gene editing, synthetic biology, and regenerative medicine. Michael shares insights into NIST's collaborations, including local companies like MedImmune/AstraZeneca and Novavax, and the importance of partnerships with academic institutions like the University of Maryland in driving local biotech advancements.   We also explore specific technologies and standards such as gene delivery systems, the NIST Monoclonal Antibody Reference Material (NISTmAb), and the National Institute for Innovation in Manufacturing Biopharmaceuticals (NIIMBL). Michael discusses the goals for future research and collaborations and reveals the next big developments we should anticipate in the biotech field.   Don't miss this engaging conversation as we uncover the innovations and initiatives at NIST that are shaping the future of biotechnology and healthcare.  

In this engaging episode of the College Knowledge Podcast, sponsored by the College Planning Network and Paradigm Financial Group, Professor Lisa Bullard, a distinguished educator and director of undergraduate studies in the Department of Chemical and Biomolecular Engineering at NC State, shares her invaluable insights into the world of engineering education and career preparation. Here are the pivotal moments:- Bullard's Journey and Career Insights: Professor Bullard recounts her personal journey from an interest in journalism and photography to becoming a prominent figure in chemical engineering education. She emphasizes the importance of exploring diverse interests and the pivotal role of mentorship in shaping her career path, illustrating the nonlinear nature of career development.- Evolution of Women's Colleges: The podcast begins with an enlightening discussion on the historical and current landscape of women's only colleges in the United States, shedding light on the changing dynamics of higher education and gender-specific institutions.- The Value of Internships: Bullard highlights how internships significantly influenced her career, providing clarity and direction by revealing what aspects of chemical engineering were appealing and which were not. This segment underscores the importance of hands-on experiences in discovering one's true passion and career path.- Advice for Prospective Engineering Students: Offering practical advice to high school students contemplating a future in engineering, Bullard stresses the importance of exposure to the field through conversations with professionals, exploration of various engineering disciplines, and understanding the diverse career paths available within engineering.- Educational Pathways and Mentorship: The conversation delves into the structure of engineering education at NC State, the strategic approach to guiding students through their first year, and the critical role of mentorship in assisting students in navigating their academic and professional journeys. Bullard's insights serve as a testament to the supportive educational environment at NC State and the broader engineering community.This episode of the College Knowledge Podcast serves as a comprehensive resource for students, parents, and educators alike, offering a deep dive into the intricacies of engineering education and the vital components of career preparation in the modern world. Video Version of Podcast YouTube:The College Knowledge PodcastFollow us on social media:InstagramFacebookLinkedInVisit us online:The College Knowledge Podcast WebsiteElite Collegiate Planning

The following Metabolic Link episode was originally filmed at Metabolic Health Summit 2024 and we're excited to share it with you today in its entirety! In this presentation, Dr. Andy Galpin, a human performance scientist, shares his insights on utilizing scientific principles, specifically the 'Biomolecular Athlete' concept, to achieve athletic excellence. He emphasizes the importance of individualized strategies that consider sleep, diet, stress, respiratory rates, and blood chemistry.The discussion then progresses to the groundbreaking future of human performance, including the use of digital twins for simulating and optimizing individual health outcomes, and the exploration of advanced technologies such as in-mouth sensors, full-body MRI, shoe sole force plates, and markerless motion capture.Case studies are presented to illustrate the successful application of these innovative approaches, showcasing the potential for precision and customization in coaching for optimal health and performance.This talk is sponsored by Genova Diagnostics. Genova has been researching and refining precision health testing for decades. It's that experience that has allowed them to create comprehensive assessments that shed light on your individual health status and make recommendations for changes that will bring your wellness into focus.Genova Connect, powered by Genova Diagnostics, offers easy access to advanced lab tests, covering key health areas like metabolic health, nutrition, gut health, immune function, and hormones. Through Genova Connect, anyone can gain insights into their health and find ways to improve their well-being. Learn more at gdx.net/themetaboliclinkAs mentioned in the introduction, you can watch this free virtual masterclass co-hosted Genova Diagnostics and Metabolic Health Summit showcasing some of the world-leading experts in metabolic health.In every episode of The Metabolic Link, we'll uncover the very latest research on metabolic health and therapy. If you like this episode, please share it, subscribe, follow, and leave us a comment or review on whichever platform you use to tune in!You can find us on all your major podcast players here and full episodes are also up on our Metabolic Health Summit YouTube channel, Apple, Google, Spotify, Amazon Music, and Buzzsprout.Thanks for listening! Follow us on social media @metabolichealthsummit for the latest science on metabolic health and therapy. Please keep in mind: The Metabolic Link does not provide medical or health advice, but rather general information that does not serve as a substitute for a licensed healthcare professional. Never delay in seeking medical advice from an appropriately licensed medical provider for any health condition that you may have.

Dr. João Vaz é Diretor da NutriClinica. Ele estudou Nutrição na UNIPAC MG, Nutrição Clínica Funcional na UDF DF, Orto e Biomolecular na UCG GO e Tratamentos Naturais no Instituto de Naturopatia Curitiba. Ele é palestrante internacional e autor do Livro “Vida Longa Esgotado” e já ajudou inúmeros pessoas para recuperar a sua saúde através de uma abordagem mais abrangente da saúde. --- Send in a voice message: https://podcasters.spotify.com/pod/show/ricardoferrer/message

Any way we can lower carbon footprints is worth pursuing. Greeshma Gadikota, associate professor and Croll Sesquicentennial Fellow at Cornell University, looks into one. Dr. Greeshma Gadikota is an Associate Professor and Croll Sesquicentennial Fellow in the School of Civil and Environmental Engineering with a field appointment in the Smith School of Chemical and Biomolecular […]

Professor Matthew Collins  is a Niels Bohr Professor at the University of Copenhagen and the McDonald Chair of Palaeoproteomics at  the McDonald Institute for Archaeological Research at the University of Cambridge. We discuss his journey to becoming a leading academic in the field, and his interests within the discipline.Within the world of biomolecular archaeology we track through palaeoproteomics and its applications, the integration of scientific disciplines into archaeology, and  ZooMS (Zooarchaeology by Mass Spectrometry).For more archaeology and anthropology check out our website at www.sphinxthinks.com

Link to bioRxiv paper: http://biorxiv.org/cgi/content/short/2023.07.28.551061v1?rss=1 Authors: Keyport Kik, S., Christopher, D., Glauninger, H., Wong Hickernell, C., Bard, J. A. M., Ford, M., Sosnick, T. R., Drummond, D. A. Abstract: Cells must sense and respond to sudden maladaptive environmental changes--stresses--to survive and thrive. Across eukaryotes, stresses such as heat shock trigger conserved responses: growth arrest, a specific transcriptional response, and biomolecular condensation of protein and mRNA into structures known as stress granules under severe stress. The composition, formation mechanism, adaptive significance, and even evolutionary conservation of these condensed structures remain enigmatic. Here we provide an unprecedented view into stress-triggered condensation, its evolutionary conservation and tuning, and its integration into other well-studied aspects of the stress response. Using three morphologically near-identical budding yeast species adapted to different thermal environments and diverged by up to 100 million years, we show that proteome-scale biomolecular condensation is tuned to species-specific thermal niches, closely tracking corresponding growth and transcriptional responses. In each species, poly(A)-binding protein--a core marker of stress granules--condenses in isolation at species-specific temperatures, with conserved molecular features and conformational changes modulating condensation. From the ecological to the molecular scale, our results reveal previously unappreciated levels of evolutionary selection in the eukaryotic stress response, while establishing a rich, tractable system for further inquiry. Copy rights belong to original authors. Visit the link for more info Podcast created by Paper Player, LLC

Link to bioRxiv paper: http://biorxiv.org/cgi/content/short/2023.07.24.550444v1?rss=1 Authors: Torrino, S., Oldham, W., Tejedor, A. R., Sanchez-Burgos, I., Rachedi, N., Fraissard, K., Chauvet, C., Sbai, C., O'Hara, B. P., Abelanet, S., Brau, F., Clavel, S., Collepardo-Guevara, R., Rene Espinosa, J., ben-sahra, I., BERTERO, T. Abstract: Biomolecular condensates regulate a wide range of cellular functions from signaling to RNA metabolism1,2, yet, the physiologic conditions regulating their formation remain largely unexplored. Biomolecular condensate assembly is tightly regulated by the intracellular environment. Changes in the chemical or physical conditions inside cells can stimulate or inhibit condensate formation3,5. However, whether and how the external environment of cells can also regulate biomolecular condensation remain poorly understood. Increasing our understanding of these mechanisms is paramount as failure to control condensate formation and dynamics can lead to many diseases6,7. Here, we provide evidence that matrix stiffening promotes biomolecular condensation in vivo. We demonstrate that the extracellular matrix links mechanical cues with the control of glucose metabolism to sorbitol. In turn, sorbitol acts as a natural crowding agent to promote biomolecular condensation. Using in silico simulations and in vitro assays, we establish that variations in the physiological range of sorbitol, but not glucose, concentrations, are sufficient to regulate biomolecular condensates. Accordingly, pharmacologic and genetic manipulation of intracellular sorbitol concentration modulates biomolecular condensates in breast cancer, a mechano-dependent disease. We propose that sorbitol is a mechanosensitive metabolite enabling protein condensation to control mechano-regulated cellular functions. Altogether, we uncover molecular driving forces underlying protein phase transition and provide critical insights to understand the biological function and dysfunction of protein phase separation. Copy rights belong to original authors. Visit the link for more info Podcast created by Paper Player, LLC

Link to bioRxiv paper: http://biorxiv.org/cgi/content/short/2023.05.02.539089v1?rss=1 Authors: Vural, A., Lanier, S. M. Abstract: Copy rights belong to original authors. Visit the link for more info Podcast created by Paper Player, LLC

Link to bioRxiv paper: http://biorxiv.org/cgi/content/short/2023.03.22.533832v1?rss=1 Authors: Nixon-Abell, J., Ruggeri, F. S., Qamar, S., Herling, T. W., Czekalska, M. A., Shen, Y., Wang, G., King, C., Fernandopulle, M. S., Sneideris, T., Watson, J. L., Pillai, V. V., Meadows, W., Henderson, J., Chambers, J. E., Wagstaff, J. L., Williams, S. H., Coyle, H., Lu, Y., Zhang, S., Marciniak, S. J., Freund, S. M., Derivery, E., Ward, M. E., Vendruscolo, M., Knowles, T. P., St George Hyslop, P. Abstract: Phase transitions of cellular proteins and lipids play a key role in governing the organisation and coordination of intracellular biology. The frequent juxtaposition of proteinaceous biomolecular condensates to cellular membranes raises the intriguing prospect that phase transitions in proteins and lipids could be co-regulated. Here we investigate this possibility in the ribonucleoprotein (RNP) granule-ANXA11-lysosome ensemble, where ANXA11 tethers RNP granule condensates to lysosomal membranes to enable their co-trafficking. We show that changes to the protein phase state within this system, driven by the low complexity ANXA11 N-terminus, induce a coupled phase state change in the lipids of the underlying membrane. We identify the ANXA11 interacting proteins ALG2 and CALC as potent regulators of ANXA11-based phase coupling and demonstrate their influence on the nanomechanical properties of the ANXA11-lysosome ensemble and its capacity to engage RNP granules. The phenomenon of protein-lipid phase coupling we observe within this system offers an important template to understand the numerous other examples across the cell whereby biomolecular condensates closely juxtapose cell membranes. Copy rights belong to original authors. Visit the link for more info Podcast created by Paper Player, LLC

In this week's episode I'm chatting with my friend Jesse Adler, a biomolecular scientist and materials innovation researcher at PANGAIA. Jesse is one of my favourite people - she is one the most enthusiastic, smartest, and overall just wonderful human beings I know. We spoke about materials innovation and what in her view are the most pressing issues in terms of materials that we need to find alternatives for, and about biomimicry and how so much of what we design as humans have been inspired by nature, including for example planes. We also discussed the cyclical nature of the world we live in and how the concept of waste doesn't exist in nature.Aside from her job at PANGAIA Jesse is also a future materials research fellow at the Jan Van Eyck Academie in the Netherlands. Her research focuses on finding replacements for artificial colorants in fungi. So we spoke about the makeup collection she created using pigments extracted from various types of fungi, and how she approaches this as a collaboration rather than an exploitative extractive practice. She shared her tips for ethical foraging and also how she practices mindfulness to connect with the wider ecosystems we are part of.I've had bits of this conversation with Jesse over the past few years and it is so nice to have finally recorded it, I hope you'll find it as exciting as we did!Want to dive deeper?Jesse's portfolio - https://www.jadlerdesign.com/Learn more about Alchemical Mycology - https://www.jadlerdesign.com/alchemical-mycologyLearn more about biomimicry - https://biomimicry.org/what-is-biomimicry/Watch Fantastic Fungi on Netflix - https://www.netflix.com/title/81183477Entangled Life by Merlin Sheldrake - https://www.wob.com/en-gb/books/merlin-sheldrake/entangled-life/9780525510321Peace is Every Step by Thich Nhat Hanh - https://www.wob.com/en-gb/books/thich-nhat-hanh/peace-is-every-step/9780712674065The Gene by Siddhartha Mukherjee - https://www.wob.com/en-gb/books/siddhartha-mukherjee/gene/9780099584575Little linksJesse on Instagram - https://www.instagram.com/jadlerdesignWhy We Care on Instagram - https://www.instagram.com/whywecarepodcast/Tiphaine on Instagram - https://www.instagram.com/tiphainemarie_/If you enjoyed the episode and want to help the podcast, I would be super grateful if you could leave a little review or share it with a friend who might like it.Thank you for caring and sending you lots of love! Hosted on Acast. See acast.com/privacy for more information.

Happy New Year, and happy 3rd official year of the Ocean Decade - and The Ocean Decade Show podcast. To kick off 2023, this month's episode features Taylor a bit out of her scientific depths discussing the Ocean Biomolecular Observing Network (OBON), an endorsed Ocean Decade Programme, which aims to develop a global system of biological observation that will allow science and society to understand ocean life like never before. Guests Dr. Sophie Seeyave - CEO of Partnership for Observation of the Global Ocean (POGO) - and Dr. Maragret Leinen - Director of Scripps Institution of Oceanography at UC San Diego - expertly guide Taylor through the importance of ocean observation, how OBON is building a global observation network, and what the Programme wants to achieve by 2030. To learn more about OBON, visit https://www.obon-ocean.org/.

In this episode, podcast host David Pechter invites SLAS Technology featured author Dr. Hossam Ibrahim (University College Dublin) to discuss his research on the dissemination of tumor cells to understand the mechanisms behind cancer metastasis. Tune in to hear how the research team developed a migration assay combining 3D models and a physiologically relevant extracellular matrix. Hear about the unique challenges faced by researchers while orchestrating the application of 3D technologies with high throughput screening methods.For more, read Dr. Ibrahim's paper "A Biomimetic High Throughput Model of Cancer Cell Spheroid Dissemination onto Aligned Fibrillar Collagen". Dr. Ibrahim is a researcher at University College Dublin (UCD) in the School of Physics and also at the Nanoscale Function Group located in the Conway Institute of Biomolecular and Biomedical Research. For more information about the journal, visit SLAS Technology or contact the SLAS publishing office at publishing@slas.org. 

Diese Spezialfolge dreht sich um die spannende interdisziplinäre Wissenschaft der Geoarchäologie. Dr. Mara Lou Schumacher erklärt, im Interview mit dem Host Maya, was Geoarchäologie ist und welche Rolle die Chemie hierbei spielt. Außerdem sprechen beide darüber, welche Grenzen es gibt und welche Methodiken man verwenden kann, um geoarchäologische Proben zu untersuchen - natürlich alles anhand von Anwendungs- und Fallbeispielen. Für alle kommenden Erstis und Studieninteressierte erzählt Mara aber auch, wie sie überhaupt zu diesem Studiengang gekommen ist, wie er aufgebaut ist und wo man Geoarchäologie studieren kann. Eine lange und vielseitige Folge für alle "Darf's ein bisschen Chemie sein?" Fans, die auch mal über den chemischen Tellerrand hinausschauen und die Nase in tolle neue und interessante, naturwissenschaftliche Disziplinen stecken wollen. Fallbeispiele zum Nachlesen: [1] Vyncke, Kim, et al. "Identifying domestic functional areas. Chemical analysis of floor sediments at the Classical-Hellenistic settlement at Düzen Tepe (SW Turkey)." Journal of Archaeological Science 38.9 (2011): 2274-2292. [2] Shillito, Lisa-Marie, et al. "Biomolecular and micromorphological analysis of suspected faecal deposits at Neolithic Çatalhöyük, Turkey." Journal of Archaeological Science 38.8 (2011): 1869-1877. Weitere Literatur zur Geoarchäologie, unter der Mitarbeit von Mara: [3] Bork, Hans-Rudolf, et al. "Künstliche Ablagerungen." Geoarchäologie. Springer Spektrum, Berlin, Heidelberg, 2022. 165-206. "Darf's ein bisschen Chemie sein?" ist eine Produktion von Zimt & Pfeffer Studio. Recherche und Skript: Anne Mayer Ton und Schnitt: Fabian Schneider Instagram @darfs_ein_bisschen_chemie_sein Facebook @darfseinbisschenchemiesein Für weitere Zusatzmaterialen, Bonus-Folgen und die Unterstützung meiner Arbeit, kannst Du auch gerne mal bei meinem Patreon-Account vorbeischauen. Impressum und Anmerkungen unter www.greenmaya.de - Mails an green_maya@web.de

In episode 3 of Exploration Science, Professor Ingrid Dijkgraaf and Dr. Amine Jmel discuss the potential of tick salivary proteins as lead molecules to develop therapeutics, vaccines, and imaging agents for applications ranging from cardiac disease to livestock immunization. DOI Links: Inhibition of platelet adhesion, thrombus formation, and fibrin formation by a potent αIIbβ3 integrin inhibitor from ticks: 10.1002/rth2.12466 Immunomodulatory Proteins in Tick Saliva from a Structural Perspective: 10.3389/fcimb.2021.769574 Exogenous Integrin αIIbβ3 Inhibitors Revisited: Past, Present and Future Applications: 10.3390/ijms22073366 Structural characterization of anti-CCL5 activity of the tick salivary protein evasin-4: 10.1074/jbc.RA120.013891 Tick Saliva Protein Evasin-3 Allows for Visualization of Inflammation in Arteries through Interactions with CXC-Type Chemokines Deposited on Activated Endothelium: 10.1021/acs.bioconjchem.0c00095 Tick saliva protein Evasin-3 modulates chemotaxis by disrupting CXCL8 interactions with glycosaminoglycans and CXCR2: 10.1074/jbc.RA119.008902 Watch on YouTube: https://youtu.be/EZBAt7Sw-e4

•Tren arrolla y mata a un hombre en Puebla•Se esperan fuertes lluvias este domingo •Taiwán busca fortalecer su seguridad •Más información en nuestro Podcast

Transcript of this podcastHello and welcome to the NanoLSI podcast. Thank you for joining us today. In this episode we feature the latest research by Rikinari Hanayama from the Kanazawa University NanoLSI and colleagues. The research described in this podcast was published in the Frontiers in Molecular Biosciences in March 2022.Learn more about their research here: WPI Kanazawa Nano Life Science Institutehttps://nanolsi.kanazawa-u.ac.jp/en/research/researchers/ReferenceHiroki Yamaguchi, Hironori Kawahara, Noriyuki Kodera, Ayanori Kumaki, Yasutake Tada, Zixin Tang, Kenji Sakai, Kenjiro Ono, Masahito Yamada, and Rikinari Hanayama.Extracellular Vesicles Contribute to the Metabolism of Transthyretin Amyloid in Hereditary Transthyretin Amyloidosis, Front. Mol. Biosci. 9, 839917 (2022).DOI: 10.3389/fmolb.2022.839917URL: https://doi.org/10.3389/fmolb.2022.839917 Biomolecular insights into protein-insolubility-related diseaseResearchers at Kanazawa University elucidate how small bio-containers enclosed by membranes are involved in a disease called ATTRv amyloidosis.  Amyloidosis is the collective name for a group of diseases characterized by the deposition of amyloids — insoluble proteins that form due to the misfolding and aggregation of soluble proteins — outside of cells.  Such depositions lead to cellular dysfunctions, and take place in patients with Alzheimer's disease, Parkinson's disease and dementia.  In the disease called hereditary (variant) transthyretin amyloidosis (abbreviated ATTRv amyloidosis), variants of the transthyretin (TTR) gene lead to TTR amyloid deposits in several organs, with symptoms including muscle weakness and cardiac failure.  It is known that the removal of amyloid proteins is promoted by so-called extracellular vesicles (EVs) — small ‘biocontainers' enclosed by a membrane — but what is unclear is whether EVs are involved in the formation and subsequent deposition of TTR amyloids in the context of ATTRv amyloidosis.  Rikinari Hanayama and colleagues from Kanazawa University have now studied the relationship between ATTRv amyloidosis and EVs, and confirm that the latter play an important role in the aggregation and deposition of TTR amyloids.The researchers first analyzed the serum of ATTRv amyloidosis patients for traces of TTR amyloid.  (Serum is blood without the clotting factors.)  They found that TTR is present in EVs derived from serum, and that the so-called V30M mutation variant of TTR aggregates at the membranes of serum-derived EVs.Hanayama and colleagues then looked at what happened when V30M-TTR amyloids were added to cell cultures, with and without serum-derived EVs.  They found that V30M-TTR amyloid aggregates are deposited on cells in a much more pronounced way when serum-derived EVs are present, indicating that serum-derived EVs promote the aggregation of V30M-TTR and their deposition on cells.From a comparison between ATTRv amyloidosis patients and healthy individuals, the scientists found that ATTRv amyloidosis is associated with a lower amount of TTR aggregates in serum-derived EVs.  The hypothesis that emerges from the experiments is that in ATTRv amyloidosis patients, the presence of V30M-TTR and EVs leads to a self-enhancing uptake of EVs; this then leads to an enhanced deposition of TTR aggregates in tissue, resulting in a decrease of TTR aggregates in serum.The findings of Hanayama and colleagues suggest that TTR in serum-derived EVs is a potential target for both ATTRv amyloidosis diagnosis and therapy.  The researchers also point to the relevance of their results on our understanding of Alzheimer's disease because TTR inhibits the nucleation of amyloid-β aggregation and its aggregation is

Jeremy Skillington, CEO of Poolbeg Pharma #POLB outlines the exclusive Licence Agreement with University College Dublin for a late preclinical stage vaccine candidate for Melioidosis, a disease for which there is no currently approved vaccine available. Highlights The vaccine candidate, which is being developed by Poolbeg as POLB 003, was invented following many years of research by Associate Professor Siobhán McClean, UCD School of Biomolecular and Biomedical Science, and was a recipient of a Wellcome Trust Award to aid its development. To read the full RNS click here

Professor Shigehisa Akine is a principal investigator at the NanoLSI WPI Kanazawa University. Professor Mark MacLachlan is an overseas principal investigator at the NanoLSI WPI Kanazawa University and faculty at the University of British Columbia. In this episode of the NanoLSI Podcast they describe recent developments in their research on nanomolecular cages for biomolecular sensing and biocompatible AFM tips for chemically probing living cells, respectively.The Kanazawa University NanoLSI Podcast offers updates of the latest news and research at the WPI-NanoLSI Kanazawa University for a global audience.The Nano Life Science Institute (NanoLSI) at Kanazawa University was established in 2017 as part of the World Premier International (WPI) Research Center Initiative of the Ministry of Education, Culture, Sports, Science and Technology (MEXT).Researchers at the NanoLSI are combining their cutting-edge expertise in scanning probe microscopy to establish ‘nano-endoscopic techniques' to directly image, analyze, and manipulate biomolecules for insights into mechanisms governing life phenomena such as diseases.Further informationWPI-NanoLSI Kanazawa University websitehttps://nanolsi.kanazawa-u.ac.jp/en/

In this episode of the Epigenetics Podcast, we caught up with Eleni Tomazou from St. Anna Children's Cancer Research Institute in Vienna to talk about her work on Epigenome-based precision medicine. The Tomazou lab studies Ewing sarcoma and the effects of Epigenetic factors on this disease. Ewing sarcoma is a type of cancer that affects bone and soft tissue of children and young adults, with a peak incidence at the age of 15. Ewing sarcoma is among the pediatric cancer types with the lowest survival rates and the development of novel therapies was obstructed by the limited understanding of the mechanisms behind the disease. Work done in Eleni Tomazou's group identified an epigenetic signature of Ewing sarcoma which, ultimately, lead to the possibility to diagnose Ewing sarcoma from liquid biopsies. The team is now looking to find actionable targets like enhancers to develop therapies, finding biomarkers to enable disease monitoring, and to further characterize these tumors to decipher intra-tumor epigenetic heterogeneity and characterize the developmental stage of the cell of origin.   References Tomazou, E. M., Sheffield, N. C., Schmidl, C., Schuster, M., Schönegger, A., Datlinger, P., Kubicek, S., Bock, C., & Kovar, H. (2015). Epigenome Mapping Reveals Distinct Modes of Gene Regulation and Widespread Enhancer Reprogramming by the Oncogenic Fusion Protein EWS-FLI1. Cell Reports, 10(7), 1082–1095. https://doi.org/10.1016/j.celrep.2015.01.042 Sheffield, N. C., Pierron, G., Klughammer, J., Datlinger, P., Schönegger, A., Schuster, M., Hadler, J., Surdez, D., Guillemot, D., Lapouble, E., Freneaux, P., Champigneulle, J., Bouvier, R., Walder, D., Ambros, I. M., Hutter, C., Sorz, E., Amaral, A. T., de Álava, E., … Tomazou, E. M. (2017). DNA methylation heterogeneity defines a disease spectrum in Ewing sarcoma. Nature Medicine, 23(3), 386–395. https://doi.org/10.1038/nm.4273 Terlecki-Zaniewicz, S., Humer, T., Eder, T., Schmoellerl, J., Heyes, E., Manhart, G., Kuchynka, N., Parapatics, K., Liberante, F. G., Müller, A. C., Tomazou, E. M., & Grebien, F. (2021). Biomolecular condensation of NUP98 fusion proteins drives leukemogenic gene expression. Nature Structural & Molecular Biology, 28(2), 190–201. https://doi.org/10.1038/s41594-020-00550-w Peneder, P., Stütz, A. M., Surdez, D., Krumbholz, M., Semper, S., Chicard, M., Sheffield, N. C., Pierron, G., Lapouble, E., Tötzl, M., Ergüner, B., Barreca, D., Rendeiro, A. F., Agaimy, A., Boztug, H., Engstler, G., Dworzak, M., Bernkopf, M., Taschner-Mandl, S., … Tomazou, E. M. (2021). Multimodal analysis of cell-free DNA whole-genome sequencing for pediatric cancers with low mutational burden. Nature Communications, 12(1), 3230. https://doi.org/10.1038/s41467-021-23445-w   Related Episodes Epigenomics (Henk Stunnenberg) Targeting COMPASS to Cure Childhood Leukemia (Ali Shilatifard) Cancer and Epigenetics (David Jones)   Contact Active Motif on Twitter Epigenetics Podcast on Twitter Active Motif on LinkedIn Active Motif on Facebook Email: podcast@activemotif.com

EPISÓDIO 15/02/22 ENTREVISTA - PRISCILLA FAGUNDES (DIGITAL INFLUENCER) E ANA GABRIELA BARROS (TERAPEUTA BIOMOLECULAR

Microbiologist Alisa Kazarina describes how cutting edge research at the crossroads of archaeology and microbiology can trace humanity's physical development while providing insight on how to treat contemporary diseases.

Hear about how to program molecules to do what you want inside a cell! This Stanford professor explains biomolecular circuits and his lofty goals in chemical engineering and bioengineering. Listen to the full talk

What is synthetic biology? Researcher and professor Dr. Xiaojing Gao introduces this cutting edge field. He explains how his lab at Stanford University engineers biomolecular circuits, which are meant to be programmable, reproducible, and friendlier to mammalian cells than non-biological molecules. Xiaojing hopes to create the building blocks of this technology, to one day better treat all sorts of medical conditions ranging from cancer to epilepsy. He also describes his path to his interdisciplinary career. Related to this episode: • Dr. Xiaojing Gao: https://cheme.stanford.edu/person/xiaojing-gao • Gao Lab at Stanford: https://gaolab.blog/ • CAR T Therapy for cancer: https://www.cancer.gov/publications/dictionaries/cancer-terms/def/car-t-cell-therapy • Targeted Therapy for cancer: https://www.cancer.gov/about-cancer/treatment/types/targeted-therapies • biological logic gates: https://phys.org/news/2020-04-cells-protein-logic-gates.html • Brain & Behavior Foundation: https://www.bbrfoundation.org/ • Cell Reprogramming With CRISPR/Cas9 Based Transcriptional Regulation Systems: https://www.frontiersin.org/articles/10.3389/fbioe.2020.00882/full • Physics Olympiad: https://en.wikipedia.org/wiki/International_Physics_Olympiad • Michael Elowitz: https://www.bbe.caltech.edu/people/michael-b-elowitz • Liqun Luo: https://profiles.stanford.edu/liqun-luo • Can we write biological “software updates” to cure disease?: https://www.sciencejournalforkids.org/articles/can-we-write-biological-software-updates-to-cure-disease/ • Workforce Development for Teachers and Scientists (WDTS) https://science.osti.gov/wdts Subscribe and find podcast updates at: http://www.k12engineering.net. Support Pios Labs with regular donations on Patreon: https://www.patreon.com/pioslabs. You'll also be supporting projects like the Engineer's Guide to Improv and Art Games, The Calculator Gator, or Chordinates! Thanks to our donors and listeners for making the show possible. The K12 Engineering Education Podcast is a production of Pios Labs: http://www.pioslabs.com.

Cathal Friel, Co-Founder & Chairman & Jeremy Skillington, CEO of Poolbeg Pharma #POLB discuss the Option Agreement they signed with University College Dublin for a Melioidosis Vaccine candidate, MelioVac, and a licence to evaluate 5 other infectious disease portfolio assets. Highlights Poolbeg Pharma , a clinical stage infectious disease pharmaceutical company with a capital light clinical model, has signed an Option Agreement to licence MelioVac, a vaccine for melioidosis, with University College Dublin ('UCD') and its inventor, Associate Professor Siobhán McClean, through NovaUCD, the university's knowledge transfer office.  The Company will continue its due diligence on MelioVac, a preclinical asset and recipient of a Wellcome Trust Award to aid its development, as well as 5 of other potential vaccine candidates discovered by Associate Professor McClean and her team, for the duration of the Option Agreement, prior to signing a 'Licence Agreement'.  Dr McClean is Associate Professor and Head of Biochemistry at the UCD School of Biomolecular and Biomedical Science. Dr McClean completed her BSc in Biochemistry in UCD and received her PhD from Imperial College London. Her research focuses on lung infections which led her to develop a platform technology to identify proteins that bacteria use to attach to human cells. These proteins have proved to be excellent vaccine candidates. Dr McClean completed some of the original research to identify the antigens associated with the Melioidosis Vaccine at TU Dublin. Poolbeg Pharma has identified melioidosis as an infectious disease of interest due to its rising incidence around the world and because there is currently no approved vaccine available. Concerns are growing about global warming contributing to the spread of the disease to traditionally non-tropical areas. Melioidosis, also known as Whitmore's disease, is an infectious disease caused by the bacterium Burkholderia pseudomallei, commonly found in the soil and surface groundwater of many tropical and subtropical regions, with diverse clinical presentations including pneumonia and severe sepsis with multiple organ abscesses. Incidence of the disease is widespread in South-East Asia, Northern Australia and India, with climate change having a substantial impact on the spread of the disease to new areas such as Brazil. There are an estimated 165,000 cases of melioidosis each year, of which as many as 89,000 (54%) are estimated to be fatal.  Other potential vaccine candidates that the Company is evaluating include those for Klebsiella pneumoniae, Escherichia coli (O157), Burkholderia cepacia complex, Pseudomonas aeruginosa and Acinetobacter baumannii. About Poolbeg Pharma Poolbeg Pharma is a clinical stage infectious disease pharmaceutical company, with a capital light clinical model which aims to develop multiple products faster and more cost effectively than the conventional biotech model. The Company, headquartered in London, is led by a team with a track record of creation and delivery of shareholder value and aspires to become a "one-stop shop" for Big Pharma seeking mid-stage products to licence or acquire. The Company is targeting the growing infectious disease market. In the wake of the COVID-19 pandemic, infectious disease has become one of the fastest growing pharma markets and is expected to exceed $250bn by 2025. With its initial assets from Open Orphan plc, an industry leading infectious disease and human challenge trials business, Poolbeg has access to knowledge, experience, and clinical data from over 20 years of human challenge trials. The Company is using these insights to acquire new assets as well as reposition clinical stage products, reducing spend and risk. It already has a Phase II ready repositioned small molecule immunomodulator for severe influenza and a portfolio of other exciting assets. The Company plans to broaden this portfolio further going forward and is in active discussions with AI data analysis platforms to help accelerate the power of its human challenge model data and biobank.

¿Cómo cuida su sistema inmune? La Dra. Lilia Cedillo Ramírez, directora del Centro de Detección Biomolecular de la universidad, explica cuál es la importancia del equilibrio en la práctica del ejercicio para mantener un buen funcionamiento del sistema inmune, el cual reconoce lo propio de lo extraño dentro de nuestro cuerpo, así como del cambio de actitud para mantenerlo sano.

En su participación, la Dra. Lilia Cedillo, Directora del centro de detección Biomolecular de la BUAP, nos plática de los beneficios de los bichos buenos: "Los probióticos"

La Dra. Lilia Cedillo Ramírez, directora del Centro de Detección Biomolecular de la BUAP, platicó con Ricardo Cartas sobre la importancia que tiene para la salud el buen funcionamiento de nuestro sistema inmune.

Vidcast:  https://youtu.be/cAmUQlHW8kE Today's medical discoveries that point to future therapy. Elephants May Help Us PREVENT Cancer Making Plant-based Meats Healthier Genetically Enhanced Heart Attack Therapy Smart Device Monitoring Of Your Psyche Antibiotics Could Treat Cancer   Elephants are one-third as likely to die from cancer even though they have 100 times as many potentially cancerous cells.  Geneticists at the University of Chicago have unraveled the mystery by their discovery that elephants possess a gene that triggers a cytokine called LIF6 to destroy cancer cells. We humans have one copy of the tumor suppressor gene p53, versus 20 copies in elephants, and we also have a version of the LIF cytokine.  Work is underway to harness for humans the gene-driven cancer preventive that works so well in elephants.   Plant-based meat and fish substitutes are all the rage, but they are not healthier than the real thing due to their abundance of saturated fat, salt, and sugar.  Food scientists at UMass Amherst are reengineering products like Impossible Meat and Beyond Meat to include key micronutrients including Vitamin D, calcium, and zinc while omitting the harmful ingredients.  These refined substitutes will be the next generation of plant-based meat and fish, and when they arrive, you'll be the first to know.   Successful therapy after heart attacks involves reestablishing blood flow by chemically or surgically eliminating the clots that prevent coronary blood flow. The problem is that enzymes in the damaged tissue prevent successful recovery. Experiments by pharmaceutical scientists at the Washington State University have elucidated this process, and they are now studying necrosis suppressor genes that, if properly activated, can prevent these destructive enzymes from preventing heart muscle healing.   A state of hyperarousal forecasts a mental health decline.  Texas A&M researchers have developed a smart device-based platform that provides early warnings that hyperarousal is underway.  The technology analyses facial clues and voice patterns from your phone's camera and microphone as well as tell-tale changes in your vital signs that your smartwatch's sensors detect to predict and warn of a impending psychic meltdown.   Certain antibiotics including the macrolides erythromycin and Zithromax kill bacteria by deactivating their ribosomes, those intracellular protein factories the act on the instructions from messenger RNA or mRNA.  Biomolecular scientists at the University of Illinois at Chicago have discovered a mechanism by which these antibiotics could possibly stop the growth of human cells and specifically human cancer cells.  We're a very long way from workable therapy, but its another example of thinking outside the biological box.   These and other cutting edge solutions are coming to your doctor's office and our hospitals…….some day soon!   https://www.cell.com/cell-reports/fulltext/S2211-1247(18)31145-8?_returnURL=https%3A%2F%2Flinkinghub.elsevier.com%2Fretrieve%2Fpii%2FS2211124718311458%3Fshowall%3Dtrue https://www.nature.com/articles/s41538-021-00099-y https://www.jbc.org/article/S0021-9258(21)00648-7/fulltext https://journals.lww.com/practicalpsychiatry/Abstract/2021/03000/Improving_Psychiatric_Care_Through_Integrated.3.aspx https://www.nature.com/articles/s41467-021-23068-1   #elephants #cancer #plantbased Meats #heartattack #smartwatch #smartphone #psychosis #antibiotics  

A Maria Júlia Marques é bacharel em Ciências Físicas e Biomoleculares pela Universidade de São Paulo e faz mestrado em Física Biomolecular também pela USP. Sua linha de pesquisa é em biofotônica, compondo o Student Chapter da Sociedade Internacional de Ótica e Fotônica pela USP. Por fim, a Maria Júlia é medalhista de prata da iGEM, uma competição internacional de Biologia Sintética promovida inicialmente pelo MIT. Para conhecer o projeto do iGEM: https://2019.igem.org/Team:USP_SaoCarlos-Brazil Para ver o Flash Talks: https://www.youtube.com/watch?v=6dwyLHohXqo&t=14s

This episode is also available as a blog post: http://biopatrika.com/2021/03/29/interview-architecture-multiphasic-biomolecular-condensates-llps/

This interview is with Dr. Emmanuel Reynaud, Lecturer and Assistant Professor at the School of Biomolecular and Biomedical Science at University College Dublin. Teledyne Photometrics Web: https://www.photometrics.com/ Twitter: https://twitter.com/Photometrics LinkedIn: https://www.linkedin.com/company/teledynephotometrics/

This episode is also available as a blog post: http://biopatrika.com/2020/07/24/re-inventing-drug-discovery-by-targeting-biomolecular-condensates/

Dra. María Lilia Cedillo Ramírez. Centro de Detección Biomolecular de la BUAP. Celebrando el día Internacional de la Mujer y la Niña en la Ciencia.

This is our fourth episode on Christopher Columbus, this time looking at his first exploration of Cuba and Hispaniola, his "pivot" in the positioning of his mission with his investors, and the preparations for the very difficult voyage home. It was during this part of the journey that Columbus established his best arguments to secure funding for the all-important Second Voyage. And, also, there's just a bunch of interesting stuff! For this episode, it might be useful to have at hand the detailed map of Columbus's journey in the Caribbean, so here it is: CWCID Selected references for this episode Samuel Eliot Morison, Admiral of the Ocean Sea: A Life of Christopher Columbus Shannon Tushingham, Charles M. Snyder, Korey J. Brownstein, William J. Damitio, and David R. Gang, "Biomolecular archaeology reveals ancient origins of indigenous tobacco smoking in North American Plateau".

Link to bioRxiv paper: http://biorxiv.org/cgi/content/short/2020.11.20.391300v1?rss=1 Authors: Neely, B. A., Stemmer, P., Searle, B. C., Herring, L. E., Martin, L., Midha, M. K., Phinney, B. S., Shan, B., Palmblad, M., Wang, Y., Jagtap, P. D., Kirkpatrick, J. M. Abstract: Despite the advantages of fewer missing values by collecting fragment ion data on all analytes in the sample, as well as the potential for deeper coverage, the adoption of data-independent acquisition (DIA) in core facility settings has been slow. The Association of Biomolecular Resource Facilities conducted a large interlaboratory study to evaluate DIA performance in laboratories with various instrumentation. Participants were supplied with generic methods and a uniform set of test samples. The resulting 49 DIA datasets act as benchmarks and have utility in education and tool development. The sample set consisted of a tryptic HeLa digest spiked with high or low levels of four exogenous proteins. Data are available in MassIVE MSV000086479. Additionally, we demonstrate how the data can be analysed by focusing on two datasets using different library approaches and show the utility of select summary statistics. These data can be used by DIA newcomers, software developers, or DIA experts evaluating performance with different platforms, acquisition settings and skill levels. Copy rights belong to original authors. Visit the link for more info

 “The reason we feel depressed or anxious, drained out, experience strong cravings for sugar or substances, have problems falling asleep at night is often linked with our very complex biochemical environment interior, and deficiencies and imbalances there.” – Dr. med. vet. Antoinette Sarasin Gianduzzo, Director of Biomolecular Restoration (Bio-R®), Nutrition & Lifestyle. When the chemistry in our brain and body is disrupted we cannot function properly. Biomolecular Restoration, or Bio-R® is an innovative and personalised clinical treatment designed to detect and rectify biochemical imbalances in order to promote physical, mental and emotional wellbeing.  In the tenth episode of The Kusnacht Practice's new podcast series, Global Sales and Marketing Director Philippe Rovere speaks with Dr. med. vet. Antoinette Sarasin Gianduzzo, Director of Biomolecular Restoration (Bio-R®), Nutrition & Lifestyle about the Bio-R® programme. Antoinette breaks down and discusses the ‘four pillars' of treatment and the expanding array of applications. The benefits of micronutrient supplementation and the science and methods to rejuvenation.    

Link to bioRxiv paper: http://biorxiv.org/cgi/content/short/2020.10.25.352823v1?rss=1 Authors: McCall, P. M., Kim, K., Fritsch, A. W., Iglesias-Artola, J. M., Jawerth, L. M., Wang, J., Ruer, M., Peychl, J., Poznyakovskiy, A., Guck, J., Alberti, S., Hyman, A. A., Brugues, J. Abstract: Many compartments in eukaryotic cells are protein-rich biomolecular condensates demixed from the cyto- or nucleoplasm. Although much has been learned in recent years about the integral roles condensates play in many cellular processes as well as the biophysical properties of reconstituted condensates, an understanding of their most basic feature, their composition, remains elusive. Here we combined quantitative phase microscopy (QPM) and the physics of sessile droplets to develop a precise method to measure the shape and composition of individual model condensates. This technique does not rely on fluorescent dyes or tags, which we show can significantly alter protein phase behavior, and requires 1000-fold less material than traditional label-free technologies. We further show that this QPM method measures the protein concentration in condensates to a 3-fold higher precision than the next best label-free approach, and that commonly employed strategies based on fluorescence intensity dramatically underestimate these concentrations by as much as 50-fold. Interestingly, we find that condensed-phase protein concentrations can span a broad range, with PGL3, TAF15(RBD) and FUS condensates falling between 80 and 500 mg/ml under typical in vitro conditions. This points to a natural diversity in condensate composition specified by protein sequence. We were also able to measure temperature-dependent phase equilibria with QPM, an essential step towards relating phase behavior to the underlying physics and chemistry. Finally, time-resolved QPM reveals that PGL3 condensates undergo a contraction-like process during aging which leads to doubling of the internal protein concentration coupled to condensate shrinkage. We anticipate that this new approach will enable understanding the physical properties of biomolecular condensates and their function. Copy rights belong to original authors. Visit the link for more info

Link to bioRxiv paper: http://biorxiv.org/cgi/content/short/2020.09.24.312330v1?rss=1 Authors: Weiner, B. G., Meir, Y., Wingreen, N. S. Abstract: Cells are home to a host of biomolecular condensates - phase-separated droplets that lack a membrane. In addition to nonspecific interactions, phase separation depends on specific binding motifs between constituent molecules. Nevertheless, few rules have been established on how these specific, heterotypic interactions drive phase separation. Using lattice-polymer simulations and mean-field theory, we find that the sequence of binding motifs strongly affects a polymer's ability to phase separate, influencing both phase boundaries and condensate properties (e.g. viscosity). Notably, sequence primarily acts by determining the conformational entropy of self-bonding by single polymers. Copy rights belong to original authors. Visit the link for more info

Con una capacidad total de procesamiento de 600 muestras diarias, y resultados en menos de 5 horas, el nuevo Laboratorio Biomolecular del Hospital Dr. Gustavo Fricke cuenta con dos robots extractores de muestra y un equipo termociclador o secuenciador térmico, que permite la reacción en cadena de la polimerasa (PCR) de forma eficiente y rápida.El nuevo laboratorio del establecimiento viñamarino podrá procesar hasta 600 muestras diarias de PCR para Covid, lo que permitirá agilizar el testeo tanto en el Hospital, como en los centros de salud de la red SSVQHasta el recinto llegó el Director (s) del Servicio de Salud Viña del Mar Quillota, Alfredo Molina Naves para visitar el nuevo laboratorio junto al Subdirector Médico SSVQ, Dr. Francisco Armijo y el Director del Hospital Dr. Fricke, Dr. Leonardo Reyes, el Director SSVQ destacó que “estamos tremendamente contentos con la puesta en marcha de este laboratorio PCR, que va a tener en su máxima capacidad, el cupo para 600 PCR para ser procesados durante un día. Así que nos entrega una capacidad tremendamente importante a nuestra red en particular y esto viene a fomentar también la estrategia del testeo que se está llevando a cabo principalmente, a través de la Atención Primaria y nuestros establecimientos de salud”.A su vez, el Director del Hospital Dr. Gustavo Fricke, Dr. Leonardo Reyes, confirmó que está “muy contento y orgulloso de todas las personas que participaron para tener ya nuestro propio laboratorio PCR, que era muy importante. Para la estrategia del Ministerio de Salud y del país es fundamental el testeo, por lo tanto requeríamos tener esta situación resuelta por parte del Hospital para nuestros pacientes que ingresan y funcionarios, y orgulloso, porque este es el laboratorio más moderno de la región, cuenta con todas las medidas de bioseguridad para el manejo de las muestras y sobre todo, para el trabajo de nuestros funcionarios . Muy contento y ahora a aportar a la estrategia de testeo del país, para efectos de lograr contener y controlar esta pandemia”.Laboratorio como Centro de Referencia RegionalEl Dr. Rodrigo Muñoz, especialista del Laboratorio Clínico afirma que “nuestro Laboratorio, como centro de referencia regional, tiene la capacidad de recibir muestras de la red del Servicio Salud Viña del Mar Quillota, para satisfacer las necesidades internas como también externas que forman parte de esta red”. El especialista explica que es “un espacio construido especialmente con los estándares que se requieren para un laboratorio clínico. En cuanto al laboratorio de biología molecular, se remodeló y se construyó, siguiendo todos los estándares que la normativa nacional nos exige como son los espacios separados para mantención de los flujos unidireccionales, generar presión negativa en las salas que lo requieren, la mantención de la esterilidad de las zonas, mediante la aplicación de luz ultravioleta germicida y también los espacios adecuados para separar las zonas limpias de sucias y poder mantener todas las normas de bioseguridad, que en los laboratorios de biología molecular de PCR, son mucho más estrictos que en el trabajo normal de laboratorio”.El Director del Servicio de Salud agregó que “hace varios meses atrás fuimos testigos de la puesta en marcha adelantada de este Hospital, producto de la pandemia en la cual nos encontrábamos a nivel mundial y local, y el Hospital ha estado a la altura. Hemos ido desarrollando todas las estrategias necesarias para poder enfrentar de la mejor manera posible esta pandemia que ninguno de nosotros sabía cómo nos iba a golpear. Por lo tanto, sumado a este laboratorio, la complejización de camas que se hizo a nivel del Hospital y de red fue realmente importante”.

Link to bioRxiv paper: http://biorxiv.org/cgi/content/short/2020.09.09.289876v1?rss=1 Authors: Munoz-Gil, G., Romero, C., Mateos, N., de Llobet Cucalon, L. I., Beato, M., Lewenstein, M., Garcia-Parajo, M. F., Torreno-Pina, J. A. Abstract: Phase separation is emerging as key principle in the spatiotemporal organization of living cells. Given its relevance in the regulation of numerous biological functions, including gene transcription and chromatin architecture, modeling biomolecular condensation is gaining interest. Yet, most models developed so far rely on specific descriptions and/or experimentally inaccessible properties. Here we propose a theoretical model, where phase separation is explained by means of interaction probabilities between particles. With minimum model requirements, particle condensates emerge above a critical interaction probability. We tested the model predictions with single molecule experiments of tunable transcription factor condensates in the nucleus of living cells. Phase separation, condensate sizes, diffusion behavior, and mobility parameters, quantified by data analysis and machine learning, are fully recapitulated by our model. Our combined theoretical and experimental approach provides a general framework to investigate the biophysical parameters controlling phase separation in living cells and in other soft matter-based interacting systems. Copy rights belong to original authors. Visit the link for more info

Link to bioRxiv paper: http://biorxiv.org/cgi/content/short/2020.08.27.271288v1?rss=1 Authors: Robles-Ramos, M. A., Zorrilla, S., Alfonso, C., Margolin, W., Rivas, G., Monterroso, B. Abstract: Biomolecular condensation through phase separation may be a novel mechanism to regulate bacterial processes, including cell division. Previous work revealed FtsZ, a protein essential for cytokinesis in most bacteria, and the E. coli division site selection factor SlmA form FtsZ{middle dot}SlmA biomolecular condensates. The absence of condensates composed solely of FtsZ under the conditions used in that study suggested this mechanism was restricted to nucleoid occlusion or SlmA-containing bacteria. Here we report that FtsZ alone can demix into condensates in bulk and when encapsulated in synthetic cell-like systems. Condensate assembly depends on FtsZ being in the GDP-bound state and on crowding conditions that promote its oligomerization. FtsZ condensates are dynamic and gradually convert into FtsZ filaments upon GTP addition. Notably, FtsZ lacking its C-terminal disordered region, a structural element likely to favor biomolecular condensation, also forms condensates, albeit less efficiently. The inherent tendency of FtsZ to form condensates susceptible to modulation by physiological factors, including binding partners, suggests that such mechanisms may play a more general role in bacterial cell division than initially envisioned. Copy rights belong to original authors. Visit the link for more info

Link to bioRxiv paper: http://biorxiv.org/cgi/content/short/2020.08.24.264655v1?rss=1 Authors: Zhang, Y., Xu, B., Weiner, B. G., Meir, Y., Wingreen, N. S. Abstract: Cells possess a multiplicity of non-membrane bound compartments, which form via liquid-liquid phase separation. These condensates assemble and dissolve as needed to enable central cellular functions. One important class of condensates is those composed of two associating polymer species that form one-to-one specific bonds. What are the physical principles that underlie phase separation in such systems? To address this question, we employed coarse-grained molecular dynamics simulations to examine how the phase boundaries depend on polymer valence, stoichiometry, and binding strength. We discovered a striking phenomenon -- for sufficiently strong binding, phase separation is suppressed at rational polymer stoichiometries, which we termed the magic-ratio effect. We further developed an analytical dimer-gel theory that confirmed the magic-ratio effect and disentangled the individual roles of polymer properties in shaping the phase diagram. Our work provides new insights into the factors controlling the phase diagrams of biomolecular condensates, with implications for natural and synthetic systems. Copy rights belong to original authors. Visit the link for more info

Link to bioRxiv paper: http://biorxiv.org/cgi/content/short/2020.07.30.229062v1?rss=1 Authors: Mompean, M., McAvan, B. S., Felix, S. S., Trevino, M., Oroz, J., Pantoja-Uceda, D., Cabrita, E. J., Doig, A. J., Laurents, D. V. Abstract: Many intrinsically disordered proteins contain Gly-rich regions which are generally assumed to be disordered. Such regions often form biomolecular condensates which play essential roles in organizing cellular processes. However, the bases of their formation and stability are still not completely understood. Considering NMR studies of the Gly-rich H. harveyi "snow flea" antifreeze protein, we recently proposed that Gly-rich sequences, such as the third "RGG" region of Fused in Sarcoma (FUS) protein, may adopt polyproline II helices whose association might stabilize condensates. Here, this hypothesis is tested with a polypeptide corresponding to the third RGG region of FUS. NMR spectroscopy and molecular dynamics simulations suggest that significant populations of polyproline II helix are present. These findings are corroborated in a model peptide Ac-RGGYGGRGGWGGRGGY-NH2, where a peak characteristic of polyproline II helix is observed using CD spectroscopy. Its intensity suggests a polyproline II population of 40%. This result is supported by data from FTIR and NMR spectroscopies. In the latter, NOE correlations are observed between the Tyr and Arg, and Arg and Trp side chain hydrogens, confirming that side chains spaced three residues apart are close in space. Taken together, the data are consistent with a polyproline II helix, which is bent to optimize interactions between guanidinium and aromatic moieties, in equilibrium with a statistical coil ensemble. In cells, the polyproline II population of these peptides could be augmented by binding profilin protein or SH3, WW or OCRE domains, association with RNA or assembly into polyproline II helical bundles. These results lend credence to the hypothesis that Gly-rich segments of disordered proteins may form polyproline II helices which help stabilize biomolecular condensates. Copy rights belong to original authors. Visit the link for more info

Alex Shirazi sits down with Dr. Miotto and Leo Groenewegen to chat about the exciting new developments from CellulaREvolution, based in the UK. Dr. Martina Miotto and is the co-founder and Chief Scientific Officer at CellulaREvolution Ltd. She began her studies at the University of Ferrara (Italy), where she completed a BSc in Biotechnology and a MSc in Biomolecular and Cellular Sciences. Subsequently, she moved to Newcastle University (UK) where she completed her PhD in corneal tissue engineering and a significant part of this involved the development of the technology underpinning CellulaREvolution. Following her successful PhD, Dr Miotto has focussed firmly on a commercial career pathway. She initially received a Newcastle University Enterprise Scholarship, followed by an ICURe Fellowship to explore further the market and value proposition. Afterwards, she was awarded an Enterprise Fellowship by the Royal Society of Edinburgh to receive mentoring and training in the business sector. Since the spin-out of CellulaREvolution from the University in July 2019, Martina has led the scientific development of the company. Leo Groenewegen is co-founder Chief Executive Officer at CellulaREvolution Ltd. Leo has extensive experience in the fields of Biotech and Pharmaceuticals. During his career he has enabled a wide array of firms to out-perform by achieving scientific, financial and commercial excellence. As Chief Executive Officer, Leo ensures that the overall goals of the company are achieved. Leo Groenewegen has previously held a position as CFO at a Swedish based biotech company, where besides financing he was also responsible for Investor relations, PR/Communications and Business Development. Some of his other experiences included positions at reputable consulting firms such as IMS Health and Deloitte. --- Support this podcast: https://anchor.fm/futurefoodshow/support

Philipp erzählt von seinem Weg an die TU Darmstadt und erklärt euch, was denn Biomolecular engineering überhaupt ist - und warum ohm Biochemie nicht genug war!

Recanati Family Associate Professor of Microbiology at the Skirball Institute of Biomolecular Medicine, Ken Cadwell, discusses the virome and how it relates to infectious and inflammatory diseases. In this episode, you will learn the following: What exactly is a virome, where it is found, and what it is comprised of What a bacteriophage is, and the ways in which it can interact with bacteria to ultimately cause the production of certain toxins What the inherent drawbacks are of “shotgun” sequencing for metagenomics, and how to overcome them Understanding the role of the virome in health is an emerging field of research. In fact, many people aren't even familiar with the term ‘virome,' which refers to the collection of viruses that inhabit living things, which of course includes humans. Dr. Caldwell's lab is focused on understanding the functional consequences of viral infections primarily through the use of mouse models and cultured human cells. Through a collaborative network, Dr. Cadwell's team is also trying to make correlations with humans directly in order to examine how viral exposure changes in individuals with certain diseases, such as irritable bowel disease (IBD). Dr. Cadwell explains the approach they take in determining what viruses are present in a particle sample, whether it be in a mouse model or the human gut. The approach involves sequencing everything that's there…which means sequencing a lot of bacteria and bacteriophages, which are viruses that infect and replicate within bacteria. Dr. Cadwell says that about 90 to 95 percent of the viruses they sequence are identified as bacteriophage.  So, what comprises the remaining five to 10 percent of viruses? Although it's a small percentage relatively, Dr. Cadwell explains that identifying these other viruses is of high interest because these are the viruses that infect animal cells directly, rather than bacterial cells. The team at Cadwell's lab is interested in seeing what viruses are present in healthy people, and why. Dr. Cadwell also shares some exciting new research findings that show the human immune system is capable of reacting to certain bacteriophages that are supposedly only inside bacteria, suggesting that researchers need to be paying a lot more attention to bacteriophages that don't seem to directly infect animal cells. Dr. Cadwell discusses a number of fascinating topics, including the norovirus (in mice and humans), symbiotic relationships between viruses and hosts and how they are similar to symbioses between humans and the human gut microbiome, why it's difficult to define what constitutes a healthy microbiome, and so much more. Tune in and check out www.cadwelllab.nyu.edu to learn more. 

El Centro de Detección Biomolecular de la BUAP te dice los síntomas por lo que se debe estar en alerta para detectar el Coronavirus, recordemos la importancia de reforzar las medidas preventivas para evitar los contagios masivos, mantente bien informado y alertas ante cualquier síntoma. --- Send in a voice message: https://anchor.fm/ldhnoticias/message

Everyone is asking for COVID-19 vaccine to be released as soon as possible. However, it takes a lot of time and resources to release a new medication into the market. In this episode, Nhan & Ishaan explain different steps in the development of medications.If you like this episode, be sure to subscribe and leave us a review on iTunes!!https://podcasts.apple.com/au/podcast/breaking-the-capsule/id1479407995Follow us on Facebook and Instagram:https://www.facebook.com/Breaking-the-Capsule-110257606996674/https://www.instagram.com/breakthecap/?hl=enEmail us at contact@breakingthecapsule.com with any questions

Escucha las recomendaciones de la Dra. Lilia Cedillo de lo que debemos de hacer ante el Coronavirus.

La OMS declaró al Coronavirus como una pandemia, después de que el número de casos en china se multiplicó 13 veces. La Doctora Lilia Cedillo Ramírez; Directora del Centro de Detección Biomolecular de la BUAP nos platica sobre el estado actual del Coronavirus en Puebla actualmente, luego de que se confirmara el primer caso positivo de Coronavirus en el estado. Este virus afecta de forma en general, pero los adultos mayores de 60 a 65 años, personas con enfermedades como diabetes, cáncer o enfermedad pulmonar, son grupos de riesgo más propensos a sufrir Coronavirus debido a un sistema imnunológico deficiente. --- Send in a voice message: https://anchor.fm/ldhnoticias/message

Dr. David Beck earned a PHD in Biomolecular Structure and Design and is the eScience Institute Director of Research and a Research Associate Professor in Chemical Engineering. Dr. Beck has been associated with eScience since 2009, formerly serving as the Director of Research for the Life Sciences. Beyond his biology and chemistry domain expertise, Dr. Beck provides experience in scientific data analytics and mining, parallel programming techniques for data intensive computing and high performance computing applications, and general  software design & engineering support. [1:10] What does post-doc mean: undergrad->PHD->post-doc (2 to 3 years to polish your skills): Biomolecular structure and Design (DNA/RNA/Protein design). How can you design new proteins/molecules. [3:05] Why start with computer science. Grew up when computers were becoming a commodity, so knew he wanted to do something with computers. His internship shaped his direction into biology/chemistry. The degree today would be bioinformatics, using computing with biology. [5:45] How David is leveraging his computer science degree, they use computers to find hidden structures in experimental data around biomolecules. [8:40] what is bio-informatics – a lot of data is generated, you need to know the right statistical models to apply to the data. [9:20] Opportunities exists in the pharmaceutical companies and also design microorganisms to remediate a contaminated site are some examples for careers. [12:10] What has David fired up is the broad adoption of data science methods in all domains of technology. There is a data revolution – called data science. [13:20] Getting through college: try new things, don’t get stuck with just the classes to get your degree expand outside of the core classes. We joked about gaming, but check out Foldit Game [15:50] ah ha moment – during graduate work was focused on simulation of proteins, he wrote those simulations. So he thought if we simulated thousands of molecule simulations and generated tons of data – but in the end the data was not really knowledge, they just had a lot of data. [18:40] – Best advice – you are not an impostor, this is a self-inflicted wound – it is all in your head and no true. And a habit – make sure there is something everyday in your job that you really love to do. Favorite Books both by Richard Rhodes: “Making the Atomic Bomb” “Energy: A Human Story” Free Audio Book from Audible. You can get a free book from Audible at www.stemonfirebook.com and can cancel within 30 days and keep the book of your choice with no cost.

La arqueología biomolecular, que trata de encontrar vestigios del pasado en restos biológicos con siglos de antigüedad, y que aparecen en yacimientos arqueológicos. Se trata de una tendencia que viene a completar las técnicas antropológicas que, en muchos de los casos y por el deterioro de los restos, son insuficientes.

La arqueología biomolecular, que trata de encontrar vestigios del pasado en restos biológicos con siglos de antigüedad, y que aparecen en yacimientos arqueológicos. Se trata de una tendencia que viene a completar las técnicas antropológicas que, en muchos de los casos y por el deterioro de los restos, son insuficientes.

Chemical and Bio-molecular Engineering major (dare you to say that five times fast!), Laolu the lax bro walks us through what life is like at Johns Hopkins as an undergraduate student, the trials and tribulations for those not in pre-med and life hacks to make it through successfully.

By the year 2020, it is estimated that we will have over 6 million workers in nanotechnology industries, says Dr. Amir Farnoud, an Assistant Professor of Chemical, Biomolecular and Biomedical Engineering at the Russ College of Engineering and Technology at Ohio University. The development of nanoscience is exploding at such a rate, it is difficult to predict with any accuracy how much and how fast the field will grow in an extremely short period of time, Dr. Farnoud adds. Nanotechnology is the science of examining extremely small things such as atoms and molecules and adjusting them to have certain beneficial characteristics. To give you an example of the tiny nature of a nanometer, if a nanometer was a marble then one meter would be the size of the Earth, Dr. Farnoud noted. Scientific journals also cite that there are 25.4 million nanometers to an inch. Nanoparticles are now used in many products from sunscreens and carpet stain protection to devices delivery lifesaving medications. Nanoparticles are being developed synthetically for everything from mundane commercial applications to highly sophisticated cancer and other disease treatments. Nanoparticles are being developed to not only fight cancer but to detect the presence of cancer within the human body. They also can detect bacteria and identify, with specificity, the types of infections a person may have so that treatments can be more effective and quicker to act. The nanoscale materials can deliver medications with pinpoint accuracy to fight diseases. They also can be quick acting or slower acting – similar to time released over-the-counter medications. This may allow immediate relief and also protect a person on a long term basis, says Dr. Farnoud. Nanoscience and nanotechnology began in 1959 with a lecture by famous physicist Dr. Richard Feynman. Advancements were made in the science in the 1980’s but it really has only been expanding, as a discipline and an industry, for the past 20 years. Commercial and medical applications are being rapidly discovered and tested as well as potential for nanoparticle toxicity. Dr. Farnoud feels that he has a personal mission to educate the public about nanotechnology. In addition to his work in the Farnoud Lab at Ohio University, he is planning to launch a national podcast to help people understand both the complexities and the usefulness of nanoscience.

This week I have been at the Center for BioMolecular Modeling (CBM), taking the workshop “Modeling the Molecular World.” This is one of several professional development workshops that introduce teachers to modeling materials and provides them with the experience necessary to confidently use them in their classroom. The Modeling the Molecular World workshop focuses on connecting the macroscopic world in which students live with the invisible world of molecules. This includes using models of all sorts during the workshop – from magnetic water molecules and mini-toober models of proteins to schematic models of membranes and components of the flow of genetic information (DNA → RNA → proteins). There is also a wide variety of different teaching strategies and "pedagogical moments" interspersed throughout the course.

Proteins are nature’s machines, performing tasks from transforming sunlight into useable energy to binding oxygen for transport through the body. These functions depend on structural arrangement of atoms within the protein, which was, until recently, only possible to measure statistically, in easily crystallized samples via conventional X-ray diffraction. In the past decade, X-ray Free Electron Lasers (XFELs), a new type of X-ray source, have begun to come online. Using ultra-bright, ultrafast X-ray pulses of the Linac Coherent Light Source (LCLS) at the SLAC National Accelerator Laboratory, this technology allows us to measure not only static pictures of protein structure but to record “molecular movies” of proteins in action. Series: "Lawrence Livermore National Lab Science on Saturday" [Science] [Show ID: 33432]

Proteins are nature’s machines, performing tasks from transforming sunlight into useable energy to binding oxygen for transport through the body. These functions depend on structural arrangement of atoms within the protein, which was, until recently, only possible to measure statistically, in easily crystallized samples via conventional X-ray diffraction. In the past decade, X-ray Free Electron Lasers (XFELs), a new type of X-ray source, have begun to come online. Using ultra-bright, ultrafast X-ray pulses of the Linac Coherent Light Source (LCLS) at the SLAC National Accelerator Laboratory, this technology allows us to measure not only static pictures of protein structure but to record “molecular movies” of proteins in action. Series: "Lawrence Livermore National Lab Science on Saturday" [Science] [Show ID: 33432]

Proteins are nature’s machines, performing tasks from transforming sunlight into useable energy to binding oxygen for transport through the body. These functions depend on structural arrangement of atoms within the protein, which was, until recently, only possible to measure statistically, in easily crystallized samples via conventional X-ray diffraction. In the past decade, X-ray Free Electron Lasers (XFELs), a new type of X-ray source, have begun to come online. Using ultra-bright, ultrafast X-ray pulses of the Linac Coherent Light Source (LCLS) at the SLAC National Accelerator Laboratory, this technology allows us to measure not only static pictures of protein structure but to record “molecular movies” of proteins in action. Series: "Lawrence Livermore National Lab Science on Saturday" [Science] [Show ID: 33432]

Proteins are nature’s machines, performing tasks from transforming sunlight into useable energy to binding oxygen for transport through the body. These functions depend on structural arrangement of atoms within the protein, which was, until recently, only possible to measure statistically, in easily crystallized samples via conventional X-ray diffraction. In the past decade, X-ray Free Electron Lasers (XFELs), a new type of X-ray source, have begun to come online. Using ultra-bright, ultrafast X-ray pulses of the Linac Coherent Light Source (LCLS) at the SLAC National Accelerator Laboratory, this technology allows us to measure not only static pictures of protein structure but to record “molecular movies” of proteins in action. Series: "Lawrence Livermore National Lab Science on Saturday" [Science] [Show ID: 33432]

Proteins are nature’s machines, performing tasks from transforming sunlight into useable energy to binding oxygen for transport through the body. These functions depend on structural arrangement of atoms within the protein, which was, until recently, only possible to measure statistically, in easily crystallized samples via conventional X-ray diffraction. In the past decade, X-ray Free Electron Lasers (XFELs), a new type of X-ray source, have begun to come online. Using ultra-bright, ultrafast X-ray pulses of the Linac Coherent Light Source (LCLS) at the SLAC National Accelerator Laboratory, this technology allows us to measure not only static pictures of protein structure but to record “molecular movies” of proteins in action. Series: "Lawrence Livermore National Lab Science on Saturday" [Science] [Show ID: 33432]

Proteins are nature’s machines, performing tasks from transforming sunlight into useable energy to binding oxygen for transport through the body. These functions depend on structural arrangement of atoms within the protein, which was, until recently, only possible to measure statistically, in easily crystallized samples via conventional X-ray diffraction. In the past decade, X-ray Free Electron Lasers (XFELs), a new type of X-ray source, have begun to come online. Using ultra-bright, ultrafast X-ray pulses of the Linac Coherent Light Source (LCLS) at the SLAC National Accelerator Laboratory, this technology allows us to measure not only static pictures of protein structure but to record “molecular movies” of proteins in action. Series: "Lawrence Livermore National Lab Science on Saturday" [Science] [Show ID: 33432]

Angelo Poletti, Department of Biomolecular and Pharmaceutical Sciences (DiSFeB), Centre of Excellence for the Study of Neurodegenerative Diseases (CEND) University of Milan, ITALY speaks on “Modulation of the protein quality control system in motoneuron diseases”. This seminar has been recorded by ICGEB Trieste

Tue, 11 Jun 2013 12:00:00 +0100 https://edoc.ub.uni-muenchen.de/16529/ https://edoc.ub.uni-muenchen.de/16529/1/Heucke_Stephan_F.pdf Heucke, Stephan F. ddc:530, ddc:500, Fakultät für Physik

Dr. Andreas Acrivos, Albert Einstein Professor of Science and Engineering, Emeritus, at the Levich Institute located at the City College of New York, talks about his life and career with his former student Dr. Eric S.G. Shaqfeh, Professor of Mechanical Engineering at the Institute for Computational and Mathematical Engineering of Stanford University. Born in Greece to an affluent family, his life took a definitive turn during the German occupation of Greece in the second World War. He moved to the United States to study Chemical Engineering, with the plan of returning to his native country to build an industry. Instead, he became an integral part of American academics and was instrumental in developing the Chemical Engineering programs at UC Berkeley, Stanford University, and City College of New York. Always pushing his research beyond the formal training he received, he sought to attract the most talented and ambitious students, and served as an example to many young Greeks who chose to follow in his footsteps.

Guest: Carmella Evans-Molina, MD, PhD Host: Bruce Bloom, DDS, JD As the epidemic of type 2 diabetes in the United States grows, researchers are investigating hundreds of ways to treat and cure diabetes. Some of these methods include exogenous insulin, while other ideas being explored require more complex changes in our understanding of cellular biology. Dr. Carmella Evans-Molina, assistant professor at the Indiana University School of Medicine, who holds a faculty appointment in the division of endocrinology, diabetes, and metabolism and the Herman B Wells Center for Pediatric Diabetes Research, joins us to discuss molecular mechanisms of diabetes, and potential methods of prevention related to these mechanisms. Dr. Bruce Bloom hosts.

Guest: Carmella Evans-Molina, MD, PhD Host: Bruce Bloom, DDS, JD As the epidemic of type 2 diabetes in the United States grows, researchers are investigating hundreds of ways to treat and cure diabetes. Some of these methods include exogenous insulin, while other ideas being explored require more complex changes in our understanding of cellular biology. Dr. Carmella Evans-Molina, assistant professor at the Indiana University School of Medicine, who holds a faculty appointment in the division of endocrinology, diabetes, and metabolism and the Herman B Wells Center for Pediatric Diabetes Research, joins us to discuss molecular mechanisms of diabetes, and potential methods of prevention related to these mechanisms. Dr. Bruce Bloom hosts.

Society for Biomolecular Sciences, drug discovery, personalized medicine, clinical trials. The Society for Biomolecular Sciencesis a non-profit organization dedicated to advancing the science and art of biomolecular screening internationally. Throughout his career, Dr. Al Kolb has been involved with high-throughput screening - with a special interest in assay miniaturization. As a consultant, he assists companies in evaluating, developing and launching new drug discovery technologies.

Society for Biomolecular Sciences, drug discovery, personalized medicine, clinical trials. The Society for Biomolecular Sciencesis a non-profit organization dedicated to advancing the science and art of biomolecular screening internationally. Throughout his career, Dr. Al Kolb has been involved with high-throughput screening - with a special interest in assay miniaturization. As a consultant, he assists companies in evaluating, developing and launching new drug discovery technologies.

Our cupboards are full of stories. In this installment of What's in Your Pantry, we talk about a 4,000 year old spice, modern medicine, Lewis Carroll's famous quote about flamingos and mustard, and an invasive species that marked safe passage.Connect with us, please:AsWeEat.com, on Instagram @asweeat or join our new As We Eat community on Facebook.Do you have a great idea