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Taylor talks to Charles McCaffrey, MBA, and Genia Hachenberg, CRC, MS at the Paralyzed Veterans of America about their Veterans Career Program. The program employs CRCs located all over the country to provide free employment support and vocational counseling assistance to all veterans, transitioning service members, spouses, and caregivers. Learn more about the PVA's Veterans Career Program.Share your story or invite a client to share a story about working with a CRC here.
In this preview of the next episode of Inside Rehabilitation Counseling, Taylor talks to Charles McCaffrey, MBA, and Genia Hachenberg, CRC, MS at the Paralyzed Veterans of America about their Veterans Career Program. The program employs CRCs located all over the country to provide free employment support and vocational counseling assistance to all veterans, transitioning service members, spouses, and caregivers. Look forward to the full episode next week!
Embark on a transformative journey with me, Sean Gerber, as I share the pivotal moment of venturing into full-time cybersecurity consulting after a significant chapter of my career. It's a time of change and opportunity, not just for me but for the entire cybersecurity landscape, as we witness the shockwaves of a ransomware attack on Change Healthcare and its repercussions on entities like UnitedHealthcare. In this episode, we peel back the layers of this incident to reveal the harsh realities and potential regulatory upheavals that could redefine industry standards and hold executives' feet to the fire. Get ready for an essential discussion on the intersection of cybersecurity and accountability and how it impacts us as professionals in the field.As we navigate these turbulent waters, we also unravel the complexities of checksums and cryptographic hash functions. Understand why CRCs can't keep your data under wraps and the vital importance of collision resistance in hashing algorithms. We go beyond basic error detection and step into a world where digital signatures and certificates are the sentinels guarding our digital identities. This deep dive into the technical underpinnings of cybersecurity doesn't just prepare you for the CISSP exam; it arms you with the knowledge to fortify your data against the evolving threats in the cyber realm. Tune in and bolster your defenses with insights from the forefront of cybersecurity.Gain access to 30 FREE CISSP Exam Questions each and every month by going to FreeCISSPQuestions.com and sign-up to join the team for Free.
Certified Rehabilitation Counselors can explore a wide variety of job settings thanks to their credential. With many options and areas of focus available to them, CRCs can find themselves stuck while considering where they want their career to take them. The most common question we hear from CRCs is how do I navigate my options in private practice? Dr. Aaron Mertes is a CRC and professor at the University of Montana Billings. On the next episode of Inside Rehabilitation Counseling, hear about Dr. Mertes' career, and learn about why he recently wrote and self-published a book on career paths, options, and opportunities in private rehabilitation counseling. You can purchase Dr. Mertes' book here: https://aaronmertes.com/
Certified Rehabilitation Counselors can explore a wide variety of job settings thanks to their credential. With many options and areas of focus available to them, CRCs can find themselves stuck while considering where they want their career to take them. The most common question we hear from CRCs is how do I navigate my options in private practice? Dr. Aaron Mertes is a CRC and professor at the University of Montana Billings. On the next episode of Inside Rehabilitation Counseling, hear about Dr. Mertes' career, and learn about why he recently wrote and self-published a book on career paths, options, and opportunities in private rehabilitation counseling. Hear the full episode later this week!
This podcast features Dr. Iqbal Ahnaf, Assistant Professor at CRCS. He explores the intricate relationship between 'Religion, Violence, and Peacebuilding,' sharing profound insights based on his presentation at the ILN 10th International Conference on Peace and Prosperity in Muslim Majority Countries and Beyond, held in Kuala Lumpur on 5th-6th September 2023.
Rebekah Wilson 0:11Welcome to Elmhurst, CRCS daily dose of the Word of God. Today's Tuesday August 1, and this is Rebecca Wilson. This week we will contrast the visible with the invisible worlds by reading Colossians two verses six through 10. I'll be reading from the New Living Translation. Rebekah Wilson 0:30"And now just as you accepted Christ Jesus as your Lord, you must continue to live in obedience to Him. Let your roots grow down into him and draw up nourishment from him, so that you will grow in faith, strong and vigorous in the truth you were taught. Let your lives overflow with thanksgiving for all he has done. Don't let anyone lead you astray with empty philosophy are high sounding nonsense that come from human thinking and from the evil powers of this world, and not from Christ. For in Christ, the fullness of God lives in a human body, and you are complete through your union with Christ. He is the Lord over every ruler and authority in the universe."Rebekah Wilson 1:15As Paul continues in his letter to the Colossians, he's admonishing them in their faith. Over and over, he explains and teaches about the superiority of Christ, for whom Paul is in chains. As believers in Jesus we are to grow in our obedience to Him. Paul tells the Colossians and us to let our roots go down deep and to drop some stubbornness from Christ. Our faith grows stronger and more vigorous as we obey and put our faith to action. This naturally leads to an overflow of gratitude for Jesus as we recall his good deeds on our behalf and his faithfulness to us. Being filled with gratitude then prepares us and protects us against the enemy schemes to deceive and distract us. As Paul says, when we are full of the wisdom of Christ. The philosophy and nonsense of this world will be obvious, behind every lie or falsehood against God. There is an invisible enemy stoking the fire, the enemy had targeted the thinking of the Colossians and targets our thinking today, to distract us or confuse us or to deceive us about the truth of who God is. And we don't have to be afraid, though, because as Paul points out, the truth about Jesus already dwells within us as followers of him. Rebekah Wilson 2:39Let's pray. Father God, when I think about the fact that Jesus dwells within me and has taken up residence in my soul, I am filled to overflowing with thanksgiving. We thank you for providing a way for us to be temples of your spirit. Help us to be rooted and built up in our faith in you. Help us to be strengthened in our face so that no one is able to fool us or deceive us through hollow philosophy. Lord, we take up our shields of faith to protect us from all the enemy's flaming arrows, and we pray this all in Jesus name, Amen.
Caroline Beidler On the Grittiness of Chasing HopeHere's an incredible dose of Everyday Hope! Meet my new friend, Caroline Beidler, MSW. We talk about her incredible journey through childhood trauma, abuse, and addiction, and how she discovered hope in the “downstairs church,” as our mutual mentor Philip Yancey calls it. Caroline also had a great conversation with Philip Yancey about her book, which you can listen to here!Caroline's Official BioCaroline Beidler, BA, MSW is an author, recovery advocate and founder of the storytelling platform Bright Story Shine. Her new book Downstairs Church: Finding Hope in the Grit of Addiction and Trauma Recovery is available everywhere books are sold. With almost 20 years in leadership within social work and ministry, she is the Membership and Outreach Manager for the Association of Recovery in Higher Education, where she works with collegiate recovery programs (CRPs) and collegiate recovery communities (CRCs) and students in or seeking recovery from addiction across the globe. She is a team writer for the Grit and Grace Project and blogger at the global recovery platform In the Rooms. Caroline lives in Tennessee with her husband and four year old twins where she enjoys hiking in the mountains and building up her community's local recovery ministry.Keep coming back every day for more doses of hope!My new book is coming out on July 18, and this is the next Daily Dose of Hope I'm going to give you to get ready!You can now pre-order my new book, Hope is the First Dose: A Treatment Plan for Recovering from Trauma, Tragedy, and Other Massive Things! Coming July 18 everywhere books are sold. There are major bonuses you can get by pre-ordering, including a great playlist of hopeful songs, three chapters of the book, lock screens for your phone, and more!Hey- you can get up to six months of free access to all my paid-subscriber-only content on Substack by referring friends to sign up for my free weekly Self-Brain Surgery letter! Click the button below for more information.Self-Brain Surgery with Dr. Lee Warren is a reader-supported publication. To receive new posts and support my work, consider becoming a free or paid subscriber. This is a public episode. If you'd like to discuss this with other subscribers or get access to bonus episodes, visit drleewarren.substack.com/subscribe
The value of the CRC credential is a common topic of conversation on Inside Rehabilitation Counseling, and Ryan Bruce, Director of Client Solutions at New York Life Insurance knows it well. At New York Life Insurance, Ryan has worked in long-term disability claims, stay-at-work programs, and now his role is to tell the story of how the 45 CRCs on staff strive every day to help people navigate short or long-term disability. Ryan says the same disability accommodations that employers struggled with a decade ago are still challenges they're encountering today, and having a CRC in an organization can alleviate a lot of the uncertainty and help businesses support their employees in the best way possible.
The value of the CRC credential is a common topic of conversation on Inside Rehabilitation Counseling, and Ryan Bruce, Director of Client Solutions at New York Life Insurance knows it well. At New York Life Insurance, Ryan has worked in long-term disability claims, stay-at-work programs, and now his role is to tell the story of how the 45 CRCs on staff strive every day to help people navigate short or long-term disability. Ryan says the same disability accommodations that employers struggled with a decade ago are still challenges they're encountering today, and having a CRC in an organization can alleviate a lot of the uncertainty and help businesses support their employees in the best way possible.Stay tuned for the full episode next week!
Listen to ASCO's Journal of Clinical Oncology essay, “At a Loss: Patient Deaths and Clinical Research Coordinators” by Dr. Hermioni Amonoo, a Carol Nadelson MD Distinguished Chair in Psychiatry at Brigham and Women's Hospital and the Dana Farber Cancer Institute. The essay is followed by an interview with Amonoo and host Dr. Lidia Schapira. Amonoo puts out a call for support for clinical researcher coordinators to manage grief after patient death in clinical trials. TRANSCRIPT Narrator: At a Loss: Patient Deaths and Clinical Research Coordinators, by Emma C. Deary, BA; Elizabeth Daskalakis, BA, Janet L. Abrahm, MD; Sue E. Morris, PsyD; and Hermioni L. Amonoo, MD, MPP (10.1200/JCO.23.00040) As clinical research coordinators (CRCs) working on health outcomes research in patients with hematologic malignancies, we frequently navigate a patient's chart to coordinate study appointments and collect clinical information. When opening a patient's electronic health record, a snapshot immediately appears on the screen with the patient's medical information: demographics, problem list, medical history, allergies, medications, and so on. However, there are times when the chart does not open immediately, and our stomachs drop. A small gray pop-up box that we know all too well reads: “You are opening the chart of [patient's name], who is deceased. Date of death: [date].” We dread that pop-up box. We feel shock, followed by profound grief for the patient and their loved ones. The three words in that one sentence pack an irreversible reminder that our workplace, the place we love, is the same place in which patients and families can experience their worst nightmare. Every time we wait the seconds it takes a chart to load, we hold our breath, hoping that box does not appear. CRCs, sometimes referred to as research assistants, conduct the day-to-day activities of a research study. In human subjects research, this often means performing chart reviews, calling patients to administer surveys, meeting them at clinic visits, or talking to them about different aspects of their treatment and recovery. CRCs like us are typically young, early 20s professionals, who recently graduated from college and are still trying to figure out their career aspirations. We may have previous research experience working in undergraduate professors' laboratories on organic molecules or with student research participants. Aside from volunteer experiences, we usually have not had professional interactions with seriously ill patients. CRCs are the people patients associate with the research study in which they have enrolled. Through frequent study check-ins and phone calls, we build relationships with patients and often chat about nonclinical matters. Patients tell us about their children, grandchildren, pets, daily life, hobbies, and work. The more we meet with study patients, the more we learn about the intricacies of their lives: how they met their spouses, how much they miss seeing their families, and what they love about their hometowns. Even after only a few encounters, we form strong bonds with many patients from a wide variety of backgrounds. As we follow them along their treatment journey, we find ourselves fiercely hoping the treatment works. When a patient dies, we cannot help but think of their life partner, husband, or wife, the friends they will never see again, their children, and their grandchildren. We remember their hobbies and the thoughtful ways they greeted us before appointments. We remember the numerous phone calls we made to remind them of our meetings. We remember the days they were smiling ear to ear under their masks and the days they felt so sick that they could not pick up their heads to look at us. As CRCs, we do not communicate with patients outside the study. We are not their doctors, nurse practitioners, or anyone who has direct involvement in their care. But, we accompany them as they ride the highs and lows of cancer treatment. So, after a patient dies, we often struggle to understand our own emotions and what role we played in their lives. We record their death for the study and are expected to move on, seamlessly, after discovering someone has died. Our role as CRCs may be tiny compared to those of other providers, yet each patient's death has a profound impact on us. We recall the first time we learned that one of our patients died. We became motionless at our desk, distracted and unproductive for the remainder of the day as our thoughts returned again and again to that unexpected warning box. We were hesitant to even speak to each other about how we felt. Thoughts of “I should not be feeling this upset” and “maybe I am overreacting” blocked us from processing or trying to understand our grief. These thoughts were isolating, and we were unaware that many of our colleagues could help us share this burden. Knowing that patients with serious illnesses die did not protect or prepare us for the waves of emotion we experienced when a patient in our study died. Some of us have had personal losses after which we also thought: “Maybe I do not have the right to be upset”— a childhood friend we are no longer close to dies, or we learn that a good friend has had a miscarriage—and our grief is confounded by our feelings of guilt. We experience disenfranchised grief1: grief that is not openly acknowledged, socially accepted, or publicly mourned. For us, there is no place to grieve with the patient's family or the clinical care team. Over time, our grief builds up, and it is hard to find a way to release it. Friends and family do their best to understand, but because they do not work in health care, they can find it difficult to grasp the complex emotions we experience. We seek solace with each other, but lacking coping mechanisms or clear direction, we ultimately bury our grief to continue doing our job. Oncology and palliative care clinicians routinely care for seriously ill and dying patients. To learn how they deal with their grief, we asked our Dana-Farber Cancer Institute study principal investigator and three palliative care clinicians (two physicians and a psychologist, who is a bereavement expert) how we could begin to process our otherwise disenfranchised form of grief. We learned that Dana-Farber Cancer Institute palliative care clinicians hold weekly bereavement rounds or remembrance2: a time carved out every week to read a poem or listen to a song and then share meaningful stories about each patient who touched their lives and had died that week. We adapted the bereavement rounds for our laboratory group of CRCs and principal investigators. We spoke about each patient we had lost, sharing the things that most affected us over the course of our interactions with them. We spoke of Jack (names are changed to protect patient identities), who was beloved by everyone in the clinic. His hearty laugh could be heard throughout the halls whenever he came in for a visit. On the last clinic visit before he died, Jack's appointment was delayed, and he sat in the waiting room for over an hour. When we offered to help find him a room, he stood up and offered a hug in gratitude. The memory of such a seemingly routine request stayed with us for weeks after his death. When we spoke about Jack and his family during these bereavement rounds, we were able to share the wave of grief that overwhelmed us, that grief we had kept suppressed for over a year. We also shared stories about James (names are changed to protect patient identities) and his wife; they met in college and had been together for more than 50 years. Throughout his treatment, James told us often how upsetting it was that his immunosuppression prevented him from spending time with his grandchildren in person. Our hearts broke thinking of his wife and the reunions with grandchildren that would now never happen. Surprisingly, speaking about patients in our studies who died felt like a welcome release; finally sharing these memories and the worries we had harbored since each patient's death was restorative. Bereavement rounds have been invaluable in processing the grief we experience throughout the year. We found ourselves wishing we had known of them sooner, although it would be hard for CRCs who do not work with palliative care programs to be told about them. Through our quarterly bereavement rounds, we have learned to foster healthy grieving processes, creating time to honor each patient and acknowledge their impact on us. This investment in our health and well-being has been crucial to maintaining resilience in the face of challenges that our job entails. We feel cared for by the larger program and know it is investing in us as whole people. Our professional development now extends beyond Health Insurance Portability and Accountability Act training and Collaborative Institutional Training Initiative certification to include education in bereavement, burnout, self-care, and compassion fatigue. Direct supervision and mentorship around grief and loss incorporated into our routine check-ins and meetings have been helpful, as well as an open door policy with our supervisors for informal support. We frequently debrief in response to challenging interactions or situations, including the death of a patient. The designation of this safe space has emphasized a culture of support in our team settings. Learning to lean on each other when faced with emotional experiences has become a core aspect of sharing regular study responsibilities, especially when a patient dies. One practical strategy which has helped us is going on a grief walk. After learning of a patient's death, we stop work and take a 15-minute walk, either alone or with a colleague. We give ourselves the space and time we need to begin our grieving process. Losing patients is part of our job as CRCs, as it is for many health care providers. Implementing programs and routines to understand and lessen the emotional burden on us has helped us better navigate our duties while fostering the coping strategies we need to do our job well. We want to learn and to immerse ourselves in academic medicine, and to do this, we need the support of our research team and institutions if we are to navigate the grief we feel when our patients die. Dr. Lidia Schapira: Hello and welcome to JCO's Cancer Stories: The Art of Oncology, which features essays and personal reflections from authors exploring their experience in the field of oncology. I'm your host, Dr. Lidia Schapira, Associate Editor for Art of Oncology and a professor of medicine at Stanford University. Today we are joined by Dr. Hermioni Amonoo, Carol Nadelson MD Distinguished Chair in Psychiatry at Brigham and Women's Hospital and the Dana Farber Cancer Institute. In this episode, we will be discussing her Art of Oncology article ‘At a Loss: Patient Deaths and Clinical Research Coordinators'. At the time of this recording, our guest has no disclosures. Hermi, welcome to our podcast and thank you for joining us. Dr. Hermioni Amonoo: Thank you, Dr. Shapira, for the warm welcome and introduction. Dr. Lidia Schapira: Let me start our show by asking this very broad question, and that is how did this article come about? We normally have first-person reflections in Art of Oncology, but this is a group reflection pulled by collective first-person plural, and clearly, you played an important role. How did this start? Dr. Hermioni Amonoo: So as you know, my line of research is trying to understand the well-being needs of patients with hematologic malignancies who are undergoing hematopoietic stem cell transplantation. So this is a really seriously ill group of patients who we are trying to understand what well-being looks like for them in the midst of a serious illness and quite intensive treatment with several toxic side effects and a prolonged recovery. And so in doing this work, unfortunately, a lot of our patients, even in our trials, pass away either from their diseases or complications from the treatment. And so I have noticed over the past few years that a lot of my clinical research coordinators who are young, 20-something-year-old, freshly minted college graduates, who are very critical to the work that we do, have to grapple with the loss that comes with working with our patient population. A lot of these individuals take on these clinical research coordinator roles because they want firsthand experience with patients, but that is one thing. But then working with patients who you bond with, even from mundane conversations, and then having them die was a huge sense of loss and frankly, a bit of a surprise for them. And so, as a psychiatrist, used to sitting with people in grief and helping them reflect different losses that they encounter, but I quickly realized that supporting my CRCs was a little bit more than even what my training had prepared me for and definitely, my training as a researcher hadn't prepared me adequately to be able to support these young clinical research coordinators. And so in our struggle, or I would say I've had a burden for this for several months, I would say a couple of years now. And so one of the ways that I struggle, I manage different burdens is to write about it. So I sort of shared the idea with my clinical research coordinators, a couple of them now, and they really caught on to the idea. And so we decided to share what our experience has been with this. And then I also reached out to a couple of colleagues in palliative care and the director of bereavement services at our cancer center to also support us, or support me to support our clinical research coordinator. So that's sort of how this idea came about. And that's a really long-winded response. I'm sorry. Dr. Lidia Schapira: It's so interesting to think about this, writing as a tool for processing a difficult experience is something that we often discuss with our authors for first-person narratives. What makes this entry and this essay so original, in my opinion, is that this is a group effort and you have so beautifully spoken about the need to, especially for these very young 20-something-year-olds, to process this very difficult experience of grief. And in addition to this manuscript, you speak here of doing this through some form of bereavement rounds, something that you've taken from a clinical setting where we find that it helps support people working with patients who are very ill and who experience a lot of losses to the setting of a research lab. Tell us a little bit about how that idea came about, how you're implementing this very original and useful tool in your own group. Dr. Hermioni Amonoo: It started out with, before instituting what we call remembrance rounds, my CRCs would typically call me whenever they heard of a patient's death. They will literally call my cell phone, I'll stop everything and sort of take a moment of silence with them and ask them how they were doing and check in via supervision and things like that. But it definitely felt inadequate considering the amount of pain that they experienced with the whole process. And so our palliative care teams have this remembrance of bereavement rounds every week. And obviously, on a palliative care service, they have a lot of patient deaths per week where pretty much every clinician on the team would get together for half an hour to an hour. You have different members leading these rounds where someone will share about a patient who had passed away, a memory or something about the patient, and the whole group will reflect on it. For our purposes, we thought it would be great to adapt that for like a lab setting. Fortunately, we don't have a huge volume of patient deaths per week but we realized that a month or every three months we would have close to between five to ten patients who would die from our trials, which is, again, a lot. And so, in conversations with our Director of Bereavement Services and our palliative care colleagues, we picked that time frame every quarter to get together as a lab where the names of patients in our trials who have passed away would be shared. And different members of the team who have interacted with a given patient will share, like a memory, either from a conversation, a poem, or a song, or something that brought to life the individual as a way to just process and acknowledge the loss that comes with losing patients. And I think it's also even more critical in the lab setting because, unlike the clinical setting where there is some form of a closure because as a clinician you may be able to call the patient's family and you sort of have permission to do that. But in the research setting, my CRCs felt like once they recorded the patient had died, they had no business in calling family members or doing anything like that. And so it was helpful to create the safe space to process all of that. In addition to the remembrance rounds, we also arranged with our bereavement services in the cancer center where there are actually cancer center bereavement cards where clinicians could write notes to families. And so our CRCs have started doing that as well, where we could use the cancer center template and if they wanted to, could write a note to the family as a way to share how they were feeling about the situation with the families as well. So that is something that in addition to bereavement rounds, we started doing which is also helpful. Dr. Lidia Schapira: I was very moved and I was very struck, as were the reviewers, by a few things in your article. One, is that you take responsibility for supporting your research assistants. Two, is that you take on what I will say is an almost mentorship role for helping them process this in a way that sort of still leaves them engaged with the content material and stimulates their growth as professionals. And hopefully, some of them will be future medical students, physicians, and maybe even oncologists and psychiatrists. In fact, our reviewers wrote that after reading your paper, they had implemented similar protocols in their own labs and that's pretty amazing. So tell us a little bit more about how your efforts, you think, contribute to creating a more supportive culture in general in our workplaces, both in the lab and research setting, but also this translates into clinical settings. Dr. Hermioni Amonoo: So I think maybe more so than others, I see my clinical research coordinators as really critical partners in the work that we do, especially in clinical research. They are the face of the trials that we do in some ways. They meet all our patients who are eligible for our studies. And they do spend a lot of time with them, especially in the longitudinal studies that we do, where there are multiple assessments. They are calling patients, they are speaking with them in waiting rooms, and they are really essential to a lot of things that we do. When I think about how much we compensate them monetarily wise, it really isn't a lot for really talented college graduates. And so I think, for me, I view an intangible way of making this whole experience worth it, based on how much they contribute to my research program, is to really mentor them. I think as an individual, mentorship has been very critical to my own career development, and working and mentoring CRCs is one way that I pay it forward. And I think because that is very much a part of our lab and our team culture, the CRCs are also willing to go above and beyond and really contribute to the work that we do. Because there is so much that as a principal investigator, you can't always be with them 10 hours in the day that they are working. But when you really get them to latch onto the heart of what you're doing and knowing that they are also going to grow professionally and explore different things about medicine, in general, has been really rewarding. In fact, I've had research coordinators who came in thinking they wanted to do Ph.D. in psychology programs, but then in interacting with patients, they have expressed interest in potentially pursuing nursing. I have a CRC now who came in thinking one thing and is going to nursing school this summer. And so I think there's really a great opportunity to expose them to the breadth of clinical experiences like in medicine. And one way to do that is to be intentional about looking for opportunities to allow them to see things beyond what they even thought they wanted to gain out of the experience because we can't pay them as much. Dr. Lidia Schapira: Let me tell you that after this podcast you will be getting emails from people who want to work with you. It sounds like you're an ideal mentor and so collaborative and so generous in your mentorship. It's amazing. I was also thinking, as you were speaking about the people involved with patients and families who are struggling through very difficult times and die, some of our staff, not the ones involved in research, but the people who book appointments and get to know the patients and listen to their stories, they also need a place to grieve and they need to be notified when patients die. And most of us don't have sort of a system or a process for thinking about that, and maybe we should, taking a page from your playbook here of thinking about all of the people who interact with patients and all of the people who are themselves impacted by what happens to these people we take care of and many of whom are so generous as to participate in our research studies. So let me end with a forward-looking question and that is do you have, as a researcher, any interest in studying this? Dr. Hermioni Amonoo: Again, thank you for your really generous and nice comments about the mentorship. And I totally agree with you that there is definitely room to care for a broader range of our clinical team, not just people who have hands-on clinical duties or interactions with our patients. And I think it's even more pertinent in these times post the COVID pandemic, where a lot of individuals who work in clinical settings and again, COVID being the great revealer, it sort of uncovered how a cross-section of hospital staff are really impacted by different difficult things that happen in the hospital. So I think there is a lot of room to even look at how different staff manage loss and grief of patients. And patients dying is just one form of loss that we all have to grapple with as clinicians. But I think it's an area that a lot of people haven't even considered before, and I think there's a lot of room to study the impact of some of the things that we are doing in a research setting. I am open to that. I would need collaborators to do that, because to be able to do it well, I think it's not like an area of expertise yet. I feel like I am growing in this space myself, which was part of the impetus for reflecting in this perspective. I know the director of bereavement services has also been open to extending this to other labs in our cancer center and so I am totally open to that. And if anyone is interested in exploring this in a more rigorous and robust way, as it does deserve, I think I'm open to collaborating with others to pursue this to its fullest. Dr. Lidia Schapira: That's good for all of us. And my last question, Hermi, you've been so generous with your time, is this: if you look back or think back about your early days, your formative years as a student, or maybe if you also worked as a research assistant, did you have a mentor who took the time to listen to how these experiences were falling on your soul? Not just whether or not you showed up for work every day, but how you were thinking about this and taking stock of your own losses. Dr. Hermioni Amonoo: So yeah, I think I have had a village of mentors who have been really invested in me as a human being first beyond work-related interest, and I think that has been really instrumental. And I think my mentors have had to explore some of these topics with me because of my own personal losses and I think having family deaths over the course of my training. And so I've been really privileged to be a beneficiary of mentors who really focus on helping their mentees grow. Not just in a technical way or a career development or professional sense, but really being attuned to how much, for lack of a better word, someone being well in their soul and in their mind, really is interconnected to how well they do professionally such that you don't burn out or lose the sense of joy in the things that we are doing. So I've definitely been a first-hand beneficiary of that, and my psychiatric training probably also makes me a little bit more attuned to those things than probably in other fields of medicine. Dr. Lidia Schapira: Well, thank you for a wonderful conversation. Thank you for the work that you do and for sending your work to Art of Oncology, the JCO. So until next time, thank you all for listening to JCO's Cancer Stories, The Art of Oncology. Don't forget to give us a rating or review and be sure to subscribe so you never miss an episode. You can find all of ASCO shows at asco.org/podcast. The purpose of this podcast is to educate and to inform. This is not a substitute for professional medical care and is not intended for use in the diagnosis or treatment of individual conditions. Guests on this podcast express their own opinions, experience, and conclusions. Guest statements on the podcast do not express the opinions of ASCO. The mention of any product, service, organization, activity, or therapy should not be construed as an ASCO endorsement. Show Notes: Like, share and subscribe so you never miss an episode and leave a rating or review. Guest Bio: Dr. Hermioni Amonoo is a Carol Nadelson MD Distinguished Chair in Psychiatry at Brigham and Women's Hospital and the Dana Farber Cancer Institute.
The Hesed Project https://www.hesedprojectcrc.org/ Alliance of Reformed Churches https://arc21.org/ Better Together: A Third Way https://www.thirdway.church/ Christian Reformed Church Playlist https://www.youtube.com/watch?v=vS29CIql36Y&list=PLYSXopxC8Z9tNzwStqnIdGvTksgql5AHY Why a Split in the CRC is almost inevitable https://youtu.be/poZYRC7kJZY Upcoming challenges in the CRCNA https://youtu.be/4_W4rQw1xxc no easy options for the crcna https://youtu.be/i4DOttHGWxo CRCNA Synod 2022 Decision https://youtu.be/QK-Ukzv0xfk https://groups.io/g/crc-voices The Quest for a Spiritual Home Conference with PVK, Jonathan Pageau and John Vervaeke by Estuary Chino May 18 to 21 2023 Link for tickets https://events.eventzilla.net/e/estuary-chino-2023-2138601197 Paul Vander Klay clips channel https://www.youtube.com/channel/UCX0jIcadtoxELSwehCh5QTg Bridges of Meaning Discord https://discord.gg/J5PmNPmv https://www.meetup.com/sacramento-estuary/ My Substack https://paulvanderklay.substack.com/ Estuary Hub Link https://www.estuaryhub.com/ If you want to schedule a one-on-one conversation check here. https://paulvanderklay.me/2019/08/06/converzations-with-pvk/ There is a video version of this podcast on YouTube at http://www.youtube.com/paulvanderklay To listen to this on ITunes https://itunes.apple.com/us/podcast/paul-vanderklays-podcast/id1394314333 If you need the RSS feed for your podcast player https://paulvanderklay.podbean.com/feed/ All Amazon links here are part of the Amazon Affiliate Program. Amazon pays me a small commission at no additional cost to you if you buy through one of the product links here. This is is one (free to you) way to support my videos. https://paypal.me/paulvanderklay Blockchain backup on Lbry https://odysee.com/@paulvanderklay https://www.patreon.com/paulvanderklay Paul's Church Content at Living Stones Channel https://www.youtube.com/channel/UCh7bdktIALZ9Nq41oVCvW-A To support Paul's work by supporting his church give here. https://tithe.ly/give?c=2160640
The field of rehabilitation counseling was legislated into existence over 100 years ago. As you can imagine, some elements of the profession have changed quite a bit since its inception. Dr. Kate Kline spends time in both the classroom and private practice to keep up with all adapting elements of the field to best prepare students for what's ahead.In this episode of Inside Rehabilitation Counseling, Dr. Kline explains why she introduces herself as a "counselor, but mainly a servant." Dr. Kline explains her background, shares insights on virtual counseling, and the ways in which competitive hiring practices are shifting where CRCs work.
The field of rehabilitation counseling was legislated into existence over 100 years ago. As you can imagine, some elements of the profession have changed quite a bit since its inception. Dr. Kate Kline spends time in both the classroom and private practice to keep up with all adapting elements of the field to best prepare students for what's ahead.In this preview of the next episode of Inside Rehabilitation Counseling, Dr. Kline explains why she introduces herself as a "counselor, but mainly a servant." Tune in to the full episode next week as Dr. Kline explains her background, shares insights on virtual counseling, and the ways in which competitive hiring practices are shifting where CRCs work.
Where can CRCs work in the private sector? It's a question that crosses many newly certified rehabilitation counselors' minds. Dr. James McNeil, PhD, CRC, NCC spent a good portion of his career working for Lowe's, Prudential Financial, and Amazon before becoming an educator. In this episode of Inside Rehabilitation Counseling, Dr. McNeil puts it plainly: "wherever people with disabilities are, that's where CRCs need to be." Hear some of Dr. McNeil's insights into his time in the private sector and how CRCs can become "pioneers of the profession" to pave new career paths. From search terms to seek out in job openings and how to use your knowledge as a CRC to advocate for your expertise, we hope you enjoy this discussion.
Where can CRCs work in the private sector? It's a question that crosses many newly certified rehabilitation counselors' minds. Dr. James McNeil, PhD, CRC, NCC spent a good portion of his career working for Lowe's, Prudential Financial, and Amazon before becoming an educator. In this preview of the next episode of Inside Rehabilitation Counseling, Dr. McNeil puts it plainly: "wherever people with disabilities are, that's where CRCs need to be." Tune in to the full episode next week for Dr. McNeil's insights into his time in the private sector and how CRCs can become "pioneers of the profession" to pave new career paths.
All Home Care Matters was honored to welcome two executive directors from the California Caregiver Resource Centers to share and discuss the tremendous work that the California Caregiver Resource Centers are doing to help support families and caregivers. The California Caregiver Resource Centers (CRCs) are a network of 11 centers throughout California which annually serve over 18,000 family caregivers, who are caring for adults affected by chronic and debilitating health conditions, degenerative diseases, or traumatic brain injury. Combined, the CRCs serve every county in California. Each CRC tailors its services to its geographic area, and offers family caregivers a range of core programs from counseling and care planning, to legal/financial consulting and respite, at low to no cost. John Beleutz, Executive Director of Del Mar Caregiver Resource Center and Michelle DiBuduo, Executive Director of Valley Caregiver Resource Center, are here to represent the CRCs. John, Executive Director of Del Mar CRC since 2006, has dedicated his career to delivering quality health and social services for vulnerable people. His work experience includes: Director of the Health Education and Training Center for the Community Health Partnership, Director of US Programs and Romania Country Representative for Population Services International, and Executive Director of the Pitt County AIDS Service Organization. Michelle, Executive Director of Valley CRC since 2011, has been involved with Valley CRC in many various capacities. In 2000, Michelle was introduced to Valley CRC through her mother's illness, and then she became a volunteer. From 2000-2011 she was involved in caregiver education, outreach and fundraising. Her background includes accounting for her families' companies for over 35 years.
You are faced with a young patient with an advanced colon cancer. You suspect Lynch syndrome. He asks if he should undergo total colectomy as opposed to segmental colectomy. How do you approach such a patient? Join Dr. Carole Richard, Dr. François Dagbert and Dr. Maher Al Khaldi in their conversation about Lynch syndrome, also known as Hereditary Non-polyposis Colorectal Cancer (HNPCC). Learning objectives - To understand the rationale for universal testing for MMR deficiency of newly diagnosed colorectal cancers. - To know when to recommend screening for CRC for patients with LS and to those who have undergone resection - To understand the prevalence of cancers other than CRCs associated with Lynch syndrome, especially endometrial cancer. Please visit behindtheknife.org to access other high-yield surgical education podcasts, videos and more.
Clinical research coordinators (CRCs) are a critical underpinning to conducting high-quality clinical research, and their work contributes to the research stature of Michigan Medicine and advancing patient care. Learn more about these vital team members -- and a new career ladder that will help them lay down roots in Ann Arbor -- on the latest episode of the employee podcast! See acast.com/privacy for privacy and opt-out information.
Join this channel to get access to perks:https://www.youtube.com/channel/UCvw9kVKHEyAlZPZ6ZuOd2VA/joinText Me: (949) 415-6256My podcast is Random Musings From The Clinical Trials GuruListen on Spotify: https://open.spotify.com/show/7JF6FNvoLnBpfIrLNCcg7aGET THE BOOK! https://www.amazon.com/dp/1090349521/...Text "guru" to 855-942-5288 to join VIP list!My blog: http://www.TheClinicalTrialsGuru.comMy CRO and Site Network: http://www.DSCScro.comMy CRA Academy: http://www.TheCRAacademy.comMy CRC Academy: http://www.TheCRCacademy.comLatinos In Clinical Research: http://www.LatinosinClinicalResearch.comThe Clinical Research Circle: https://www.youtube.com/channel/UCgOSm8EN_M7xf9Xfw1m778wMy TikTok: DanSfera
THE BRIEF - Incubators and CRCs The Brief is a quick-fire show where we break down two concepts from science and business. On today's episode, Leo and Marc discuss startup incubators and the cooperative research centre program. Listen in as we discuss and connect these two concepts within 10 minutes! EON LABS : https://www.eonlabs.org/ HOSTS : Dr. Leo Stevens www.linkedin.com/in/leostevensinc/ Prof. Marc in het Panhuis www.linkedin.com/in/marcinhetpanhuis/ MUSIC : Purple Planet Music https://www.purple-planet.com Mixed by Dr. Nat Harris
THE BRIEF - Incubators and CRCs The Brief is a quick-fire show where we break down two concepts from science and business. On today's episode, Leo and Marc discuss startup incubators and the cooperative research centre program. Listen in as we discuss and connect these two concepts within 10 minutes! EON LABS : https://www.eonlabs.org/ HOSTS : Dr. Leo Stevens www.linkedin.com/in/leostevensinc/ Prof. Marc in het Panhuis www.linkedin.com/in/marcinhetpanhuis/ MUSIC : Purple Planet Music https://www.purple-planet.com Mixed by Dr. Nat Harris
Warwick Powell connects #regionalAustralianbusinesses, #marketplaces, #regionalcommunities and economic project opportunities with the growing markets of Asia and in particular, #China, #HongKong and #Macau. He's had wide experience in #cmmunitydevelopment and #regionaldevelopment and has spent 25 years engaged in regional businesses, particularly in #regionalQueensland, working across diverse industries from information technologies and communications, through to #naturalresources, #tourism, #agribusiness and property development.Some of his current roles include;Chairman at @SisterCityPartners (a not for profit regional investment banking enterprise founded to build resilient regions)Chairman at www.BeefLedger.io (a blockchain enabled integrated provenance and payments platform development and implementation in the beef supply chain)Adjunct Professor at QUTHe also has an extensive understanding of China, Australia, trade relationsIn this absorbing discussion Warwick talks about;how Australian regions can better connect with the bigger markets immediately north of Australia.why Blockchain as a technology is now 'hitting its straps' having been around about 12 and a half yearsthe main virtue of #blockchaintechnology - the ability for information, that many parties need to have confidence in, to be created and shared in a way so that all the different parties can depend on itthe problems in traditional information systems where the information that's been passed along from one player to another runs into a whole bunch of risks in terms of validity, accuracy, timeliness, authenticity, etcwhat blockchain allows us to do - to ensure that all the players involved in a particular supply chain activity are involved in the key phases of information production, validation, storage, dissemination and consumption at the same timethe shared responsibility for data integrity in blockchain, which speeds things up, reduces costs associated with having to doublecheck things, and ultimately smooths out the ways in which supply chains work#supplychainshow #beefledger uses #blockchaintechnology to improve the flow of information all the way through to the end consumer, but principally focused around the wholesale marketplace to ensure that owners of assets and buyers of assets can be confident in what they're buyinghis collaboration with @QUT and the www.futurefoodsystems.com.au CRC #CooperativeresearchcenterOne of the things about the blockchain ecosystem is that a lot of effort over the last 10 years has gone into really what I would describe as back end or back office issues.#smallbusiness using #blockchainhow #blockchain starts to tackle questions around #informationdoubtand why doubt equals discount and provenance equals profitwhy when there is doubt around the veracity of the claims you're making about your product the marketplace will discount thatwhy when the marketplace has confidence in the provenance claims of the products they're buying provenance equals profit.how to build a loyal customer base by building their confidence that what they're getting is more likely than not to be what it's meant to behow at @beefledger they are trying to create the right incentive mechanisms using blockchain technologies and smart contracts that reward the pursuit of excellencewhen the question of #informationintegrity becomes a common public goodthe reality that Australian production systems are often quite a bit more expensive than alternatives in other parts of the world, which means we really need to work very hard at the value proposition that that is sufficiently persuasive that says, look, it is a bit more expensive but there are the benefits#Australianexportersthe economic sanctions that are China putting on Australiahow he sees the next 20 to 25 years with Asia continuing its path to economic development and greater wealthAustralia as one of 15 signatory countries to the #RegionalComprehensiveEconomicPartnership (#RCEP).@ASEAN groupthe ongoing growth of China which is likely to become the world's largest economy in the next, within the next 10 yearswhy Australia needs to think seriously about the importance of #RCEP as an institutional framework.#customs #paperlesscustomsblockchain enabled digitized payments - the fast lane vs the slow lanethe need to ensure that there are sufficient pipelines for data flows.the need to build capacity throuhgh #education not only in a very traditional sense, but also amongst #SMEs, to make sure that people don't feel alienated from these new technologies.the growing marketplace for digital products In Asia because of their digital nativenesshow developing countries have been able to skip over some of the legacy infrastructure that we're still held back by and have moved straight into a mobile smartphone experiential marketwww.beefledger.iowww.futurefoodsystems.com.auwww.qut.edu.auwww.kerrcapital.com.au
Rashaki Maskani interviews Mr. Bobby.
Prior to COVID, the U.S. Department of State initiated a program using comics to facilitate English Language instruction by partnering teachers from across the globe. Although COVID caused changes in how that program was executed, lessons learned from the pilot suggest that comics are a great tool for connecting with students. Our guest, Dan Ryder, is a learning Coordinator at Overman Academy, CRCS, in Skowhegan, Maine, and a key consultant on the State Department's program. Dan explains how the program unfolded amidst the pandemic as well as success stories that were observed. To learn more about this program, or to access resources on using comics when teaching, visit the American English “Teaching with Graphic Novels” resource site at https://americanenglish.state.gov/resources/teaching-comics-and-graphic-novels
Shiva's LinkedIn: https://www.linkedin.com/in/shiva-sha... Shiva's Clubhouse Group: CRA Networking Text Me: (949) 415-6256 My podcast is Random Musings From The Clinical Trials Guru Listen on Spotify: https://open.spotify.com/show/7JF6FNv... GET THE BOOK! https://www.amazon.com/dp/1090349521/... Text "guru" to 855-942-5288 to join VIP list! My blog: http://www.TheClinicalTrialsGuru.com My Private Member Patreon Page: http://www.patreon.com/dansfera My CRO and Site Network: http://www.DSCScro.com My CRA Academy: http://www.TheCRAacademy.com My CRC Academy: http://www.TheCRCacademy.com Latinos In Clinical Research: http://www.LatinosinClinicalResearch.com My TikTok: DanSfera
David from Barcaldine has a question- "Why isn't Australian government investing heavily through various CRCs to discover how we can make the most of all the renewable free energy that we've got here in Australia?" Join host Nicole Bond as she questions some of the greatest minds in Australian renewable energy research and investment and discovers why politics has turned it's back on one of the most promising economic windfalls to rural and regional Australia. Guests include Ross Garnout, esteemed Australian economist and researcher (among many, many other things), Dr Mark Diesendorf- a member of the environment and governance group at UNSW who has done extensive work in renewable CRCs and Karin Stark, a member of Farmers for Climate Action and founder of National Renewables in Agriculture conference.
Can 20th-century credit scoring models really address the economic realities of the 21st century? By the early 2000s, many lenders had begun to worry that the old ways of scoring customers really were getting, well, old. In response, the three national credit reporting companies (CRCs), Equifax, Experian, and TransUnion, joined forces to create a more advanced credit scoring solution -- VantageScore Solutions.In this episode, we have an intimate conversation with the President and CEO of VantageScore, Barrett Burns, who joined during its formation in 2006. He shares insight to his journey that lead him to become a pioneer in the industry. Understand the process, importance, and future of credit score model development.
The Faculty of Applied Health Sciences officially became the Faculty of Health on January 1 and Lili Liu, its dean, tells us about the name change, ideas for the Faculty's future, the effect the pandemic has had on research activity, and more. Two alumni, a professor emeritus, and Waterloo's next president are named to the Order of Canada. There are nine new and renewed Canada Research Chairs from Waterloo. And we have the list of campus activities and services modified under the new shutdown rules. Links in this episode: Modified campus services: https://uwaterloo.ca/daily-bulletin/2021-01-04#we-re-back-for-2021-as-the-shutdown-continues 2020 in review: Part 1 https://uwaterloo.ca/daily-bulletin/2020-12-21#2020-year-in-review-part-1-waterloo-in-the-time-of-covid-19 Part 2 https://uwaterloo.ca/daily-bulletin/2020-12-22#2020-year-in-review-part-2-yes-there-were-highlights Order of Canada: https://uwaterloo.ca/stories/news/vivek-goel-among-recipients-order-canada Pearl Sullivan memorial: https://ticketfi.com/event/4082/virtual-celebration-of-life-for-pearl-sullivan Pension and Benefits sessions: https://uwaterloo.ca/holistic-benefits-working-group/hbr-information-session-0/registration
Join us this week for a conversation with Pedro Torres, the Assistant Director of the CRCs. This is the first episode in a new series which will be about the cultural centers at PSU. We'll be talking about racism, student activism, cultural communities, Black Lives Matter, ally-ship, and much more. Find the CRC website here: https://www.pdx.edu/cultural-resource-centers/ Global Diversity & Inclusion: https://www.pdx.edu/diversity/ Student Legal Services: https://www.pdx.edu/student-legal-services/ ______________________________________________________________ For SHAC Counseling Services, please call 503-725-2800 or visit the website: https://www.pdx.edu/health-counseling/counseling Have any questions? Fill out our google form, feel free to shoot us an email, or slide into our DMs on Instagram! Google Form for Questions: https://forms.gle/obDVnDMGWPKUtJVm6 Email: what@pdx.edu // Instagram: @psu_what (www.instagram.com/psu_what/) WHAT Website: https://www.pdx.edu/health-counseling/what Virtual Mind Spa: https://www.pdx.edu/health-counseling/virtual-mind-spa
Anita Myers, CPC, CRCS, the author of “Hearts Do Matter” is our guest this week as we celebrate Children's Grief Awareness Day on 11/19/2020. The story is about a little girl who has a very special relationship with her mother. Her mother promised she would always be with her, and she shows in the book that she kept her promise in the most loving way. Finding hearts through her daily life built an inspiration that touched not only her heart but the hearts of her family as she got married and had herown daughter. The author's message is intended to help readers who suffer loss to find gratitude within the grief and illuminate inspiration that love afterlife exists.https://bit.ly/2HcRJbDFor more information on this Interview and for contact information::
Link to bioRxiv paper: http://biorxiv.org/cgi/content/short/2020.10.13.337410v1?rss=1 Authors: Indurthi, D., Auerbach, A. Abstract: Concentration-response curves (CRCs) are characterized by a midpoint (EC50) and a high-concentration asymptote (POmax) that relate to agonist affinity and efficacy. A third agonist attribute, efficiency, is the fraction of binding energy that is applied to the conformational change that activates the receptor. Here we show that agonist efficiency can be calculated from EC50 and POmax, and estimate the efficiencies of 17 agonists of adult muscle nicotinic acetylcholine receptors (AChRs). The distribution of efficiency values was bi-modal with mean{+/-}s.d of 52{+/-}2% (n=11) and 41{+/-}3% (n=6). Efficiency is correlated inversely with the volume of the agonists' head-group. For 22 binding site mutations only aY190A affects significantly ACh efficiency, switching it from the high- to the low-efficiency population. If agonist efficiency is known, EC50 can be estimated from POmax and the receptor's level of constitutive activity can be calculated from a CRC. Copy rights belong to original authors. Visit the link for more info
You’ve got to crawl before you walk. The Nori team aims to have their carbon removal marketplace up and running this year, and to that end, they are currently running a pilot program with a handful of farmers and ranchers in the US. So, what does the process look like? What is their progress on the software product to date? What milestones has the team reached—and what are their next steps? Michael Leggett serves as the Director of Product, while Ryan Anderson joined the team as a consultant in January and is now the Supply Development Lead. Prior to Nori, Michael led design teams at Google and Facebook, and Ryan served as a Strategy Lead and Ecological Economist at the Delta Institute, a nonprofit dedicated to solving complex environmental challenges in the Midwest. Today, Michael and Ryan join Ross, Christophe, and Paul to share Nori’s progress to date. They walk us through the pilot program, discussing how the team is leveraging COMET-Farm modeling to measure the additionality of carbon stored. Michael describes Nori’s milestones in terms of software product development, and Ryan explores the value of a self-service portal for participating farmer-suppliers. Listen in for insight around the unique aspects of the Nori forward contract auction and learn how the team is incorporating feedback from suppliers, verifiers, and an expert peer-review committee as they work toward a 2019 launch of the marketplace! Resources Trey Hill on RCC EP059 Ryan Anderson on RCC EP058 COMET-Farm Granular Nori Market App Demo Invest in Nori Carbon Removal Newsroom Review RCC on iTunes Connect with Ross & Christophe Nori Nori on Facebook Nori on Twitter Nori on Medium Nori on YouTube Nori on GitHub Email hello@nori.com Nori White Paper Subscribe on iTunes Key Takeaways [2:17] The intent of the Nori pilot program Test product + methodology with US farmers, ranchers Incorporate participant feedback in real time Use COMET-Farm modeling to quantify carbon removal [8:58] How Nori thinks about additionality Measure carbon stored by NEW practices Relative to established dynamic baseline [11:38] Nori’s milestones in terms of its software product Minimal version for suppliers, verifiers and buyers Product available to farmers to enter data themselves Forward contract auction simulation (buy + sell CRCs) [18:29] The benefits of a self-service portal for suppliers Empower farmers to make business decisions Generate estimates of what stand to gain (simple + free) [24:34] How the forward contract auction works in Nori Parties agree on amount + price for future transaction De-risk acquisition and sale of commodity Nori combines with single-price Dutch auction Gives participants optionality [35:58] The role of the peer review committee in the pilot Critical for transparency, integrity + objectivity Weigh in on methodology (e.g.: additionality, permanence) [39:21] Michael’s insight on the verification process Work to create value by solving real problems Partner w/ traditional market verifiers to write guidelines
Welcome to CRCS Outdoors! If you were ever wondering who we are and what we do, here is a brief report. CRCS stands for Cuba-Rushford Central School and the outdoor program is an extension of our Fisheries and Wildlife Technology classes. Our motto is making a difference “one young hunter (fisherman or student) at a […]
Welcome to CRCS Outdoors! If you were ever wondering who we are and what we do, here is a brief report. CRCS stands for Cuba-Rushford Central School and the outdoor program is an extension of our Fisheries and Wildlife Technology classes. Our motto is making a difference “one young hunter (fisherman or student) at a time. “ In 2011-12, the schools environmental programs were featured in national magazines and television. CRCS Outdoors was featured every Saturday morning on the Pursuit Channel with 26 original shows produced right at CRCS and highlighted graduating film editor Cody Card. However, the programming would not have made it on air without support from our outstanding sponsors KA-BAR Knives, Western & Central New York Chapter of SCI, and the TRI State Chapter of SCI! As we all know the future of our hunting and fishing heritage rests in the hands of our nation’s youth. If we do not do our part and get them out there early, research says all may be lost. New York State has been slowly doing their part by lowering the hunting age and providing youth seasons. CRCS Outdoors has been making a conscious effort to do our part by providing area youth with opportunities that they may not get elsewhere. CRCS Outdoors hopes to expand nationally and bring the study of fisheries and wildlife/ hunting and fishing into the mainstream of the nation’s educational platform, and to promote student centered scientific research, studying natural resource conservation, aquatics, wildlife, forestry, land stewardship, biology/ management and conservation, Math/ Science and Technology, GIS, satellite images, remote sensing, radio telemetry, data collection and analysis. Through these opportunities students are also exposed to numerous career development opportunities as well as gaining ownership in what they do through choice in what they learn and gaining responsibility. CRCS Outdoors has traveled to South Africa to hunt, as well as anual trips to Alaska, New Zealand, Texas, and locally around NYS and PA. Students enrolled at Cuba-Rushford have the first option to participate on trips and opportunities, after that, these projects and trips are open to any student, anywhere! Awards: National Rural Educator of the Year 2017. NYS Rural Educator of the Year 2017,Presidential Award for Excellence in Math and Science Teaching Washington, DC, Named to USA Today All Teacher Team, National Winner, Named as Educator of the Year, Roger Torey Peterson Institute, Named as Educator of the Year SCI, National Environmental Educator of the Year, Awarded NYS Conservation Educator of the Year, Named to National Board for Fisheries & Wildlife Education in the USA, SUNY Cobleskill Alumni of the Year Award, Cobleskill, National Wild Turkey Federation’s Educator of the Year, Nashville, TN,Toyota Tapestry Winner, National Science Award, Awarded the Feinstone Environmental Educator of The Year
Without any doubt, knowledge is power and content is king, and you acquire both of them best outdoors. Scott Haugen of Haugen Enterprises answers the why of hunting in this ever-changing industry. For nearly twenty years, he has made a living through hunting and fishing, appeared on more than 450 TV shows, penned over 2,500 magazine articles, and written more than fifteen books. Needless to say, he is one of the living legends in the industry. As Scott breaks down what is special about hunting, find out the art of content creation and the business of the outdoors. On top of that, learn what it takes to be successful in the outdoor field and why it is essential to keep acquiring knowledge.
CRCS Outdoors began in 1993, the year I was born, when my dad started teaching at Cuba-Rushford Central School in Western New York. And he had a group of eighth grade boys approach him about they loved his science class, he was teaching shark dissections. And my dad asked, you know, what would they want […]
We know that Nori is on a mission to reverse climate change by building a platform that pays people to remove carbon dioxide from the atmosphere. But how exactly will the token economics of that platform work? Why is Nori creating its own cryptocurrency separate from its carbon removal certificates? And how can we get involved and invest in Nori? Today, Paul joins Ross and Christophe to explain Nori’s token economics and the general need for alternative currencies. They discuss how Nori tokens could serve as the reference price for carbon, why Nori tokens are separate from carbon removal certificates (CRCs), and how Nori tokens might drive innovation. Paul speaks to the challenge around creating a finite number of tokens and complying with SEC regulations. Listen in for insight on how Nori is leveraging the JOBS Act’s Regulation D exemption to sell tokens in accordance with securities law. Resources Nori’s Crowdfunding Campaign Nori White Paper Cryptoeconomics on Conversations with Tyler Rethinking Money: How New Currencies Turn Scarcity into Prosperityby Bernard Lietaer and Jacqui Dunne Klaus Lackner on RCC EP007 Klaus Lackner on RCC EP023 National Futures Association Financial Industry Regulatory Authority Paul’s Blog on Security Tokens SEC v. Howey Co. JOBS Act Rule 506 of Regulation D Key Takeaways [1:27] Nori’s latest initiatives Crowdfunding campaign Newest version of white paper [4:12] The fundamentals of token economics Number created to serve ecosystem How issued (mined or minted) Where demand comes from [5:20] The need for alternative currencies Helps small, localized communities create value Example: trash exchanged for bus tokens in Brazil [8:34] How Nori could serve as the reference price for carbon Idea for business model during ICO trend Provide capital for carbon removal projects Each token = one ton of CO2 Useful for policy makers, corporations & academics [11:39] Why Nori tokens are separate from CRCs Tokens act as commodity (liquid market) Insurance reserve in case of leakage, overestimation [15:47] How Nori tokens could drive innovation High scoring CRCs = more tokens immediately available New market incentives to reduce estimation error [18:24] The challenge around creating a finite number of tokens Too many means price too low to incentivize participation Too few creates problems in future if price too high Nori used modeling to decide on 500M tokens [21:32] The definition of a security Includes stocks, bonds and investment contracts SEC rules to limit possibility of risky investments [25:31] The parameters of an investment contract (i.e.: the Howey Test) Expectation of return based on third party Companies selling tokens qualify [26:44] How Nori is working to comply with SEC rules 506(c) of Reg Dexemption allows sale to accredited investors A+ exemption opens to non-accredited investors (up to $50M) Nori offers class A token for 7.5¢, class B token for 15¢ Meet with regulators to discuss implied dictum [33:14] The breakdown of Nori’s 500M tokens 100M on sale now 250M sold in batches over time 100M in insurance reserve 50M for Nori team [34:43] Why Nori needs the blockchain Provides immutable ledger Trace how CO2removed
The team at Nori has spent the last several months traveling the world, attending conferences around regenerative farming, agricultural technology, and the soil health movement. And the overarching theme among stakeholders has been the need for a price on carbon. How is Nori working to deliver just that? What methodologies is the platform using to measure and verify carbon removal in soil? And how does the system work to pay farmers for regenerative practices? Alexsandra Guerra is the Director of Strategic Planning for Nori. A clean energy crusader with a background in the energy and tech space, she is well-versed in the realm of data-drive projects focused on increasing distributed energy resources and grid modernization. Alexsandra believes that they key to impactful innovation is a combination of social awareness and technology, and she prioritizes efficient and sustainable practices in all aspects of her life. Today, Alexsandra once again joins Ross, Christophe and Paul on the podcast. This time, she is here to talk methodologies, explaining her current work with the product team around compensating farmers for carbon removal. She walks us through the process of enrolling in the Nori marketplace, getting your data verified, and earning Nori tokens. Alexsandra offers insight around the benefits of regenerative farming practices and the demand for a price on carbon. Listen in to understand how and why Nori is engaging stakeholders to build a usable platform based on feedback from the community. Resources Nori Webinars COMET-Farm Natural Resources Conservation Service GOAT ReGen18 VNRC Soil Workshops Carbon Farming Innovation Network University of Minnesota Main Street Project Key Takeaways [1:46] The fundamentals of Nori methodologies Current focus on soils and grazing Develop way to measure carbon removal List projects, get paid for good work [2:43] How to become a part of the Nori marketplace Enter regenerative practices on COMET-Farm Use data to estimate CO2land stores over time Issued corresponding number of CRCs [4:02] The benefits of regenerative farming practices Better yield over time, prevents soil erosion Avert economic impact of land degradation [5:53] The job of a verifier in the Nori system Confirm applicant has rights to project listed Verify accuracy of data in COMET-Farm Ensure project not on other marketplaces [8:00] How farmers get paid through Nori after verification CRCs listed in que, convert to Nori tokens once purchased Some tokens issued immediately but others held in reserve Must maintain practices for ten years [9:45] The difference between a verifier and an auditor Verifier makes sure COMET-Farm data is accurate, maintained Auditor performs occasional checks (still working on timeline) Supplier and buyer pay for both, Nori not involved in process [14:09] How the Nori marketplace provides assurance to buyers Adjust credits held in reserve if less CO2removed than projected [15:47] The theme of recent ag tech and soil health conferences Crucial need for price on carbon New practices to reduce inputs (e.g.: tree range chickens) [18:57] Why Nori is building a community of collaboration Generate input to build usable tool Prompt broad stakeholder engagement [22:46] The Nori product team’s lean methodology Apply scientific method to assumptions Customer discovery to test hypotheses
One of the tenets at Nori is Find, Don’t Whine. Rather than complaining about the complexity of reversing climate change, the startup believes in actively seeking out solutions. At the end of April, we took steps to engage a diverse group of stakeholders through the Reversapalooza Summit, inviting academics, influencers, policy-makers, potential carbon removal certificate suppliers and buyers to come together and initiate a conversation around incentivizing carbon removal by way of the blockchain. Alexsandra Guerra is one of the seven founders of Nori, and she serves as the startup’s Director of Strategic Planning. Alexsandra’s interest in reversing climate change began at 17 when she saw Dr. Klaus Lackner on the Science Channel and was inspired to pursue Environmental Engineering at Columbia. She is a clean energy and sustainability crusader working in the energy and tech space, serving as a renewable energy integration engineer at Southern California Edison for three years prior to joining Nori. Alexsandra believes that the environment-technology nexus should be used to better humanity and protect the environment, and she was the lead in organizing the Reversapalooza Summit. Today, Alexsandra joins Ross, Christophe, and Paul to sum up the Reversapalooza Summit, discussing Nori’s intent to procure feedback from a variety of stakeholders and iterate in the right direction moving forward. They briefly walk us through each session, sharing the major takeaways from Carbon Markets, Blockchain 101, and Returning Carbon to the Ground. Alexsandra reviews the Nori Trading Game, offering insight around how the simulated marketplace demonstrated Nori’s approach and uncovered effective market strategy. Listen in to understand the mindset shift inspired by the Open-Source Tech presentations and learn how the conference concluded with an intense discussion of measuring carbon removal. Resources Reversapalooza Agenda Live Illustrations from Reversapalooza COMET-Farm Nori Explainer Video Regen Network Key Takeaways [3:38] The idea behind Reversapalooza Summit held in Seattle, 105 in attendance Conversation with variety of stakeholders Feedback on whitepaper to iterate in right direction [6:27] Takeaways from the Carbon Markets Today session Carbon is not the enemy (energy improves human condition) Treat greenhouse gases as waste product, pay to collect [10:15] The value of the Nori Trading Game Simulated marketplace (CRCs and Nori tokens) Difference between cost of removing carbon, token price [14:51] Paul’s Marketplace Demo Illustrate full life cycle of Nori token Enter data, verification, CRC listed for sale [16:15] The premise of the Blockchain & Nori 101 session Illustrate difference between blockchain and crypto Ethereum’s PoS (drastic reduction in energy use) [19:42] The themes of the Open-Source Tech Presentations Shift thinking from scarcity to abundance mindset Complex, global problems benefit from collective input [23:21] An overview of the Returning Carbon to the Ground session Current scale of adoption of regenerative farming Potential to incentivize regenerative practices Emphasis on soil health vs. climate change [25:28] The aim of the Proving Carbon is Removed session Introduce methods for measuring carbon removal Explore verification protocol in blockchain space [29:01] Nori’s next steps Use feedback to continue conversations offline Apply to product, business development
The team at Nori believes that the best ideas come out of creative tension, so they are soliciting feedback on the completed draft of their white paper in order to identify any unanswered questions or potential issues before moving forward. In fact, the Reversapalooza Summit was designed for that very purpose. Dr. Klaus Lackner is the director of ASU’s Center for Negative Carbon Emissions (CNCE) and professor at the School of Sustainable Engineering. His research interests include closing the carbon cycle through direct air capture, carbon sequestration, carbon foot-printing, and energy and environmental policy. Klaus was the first to suggest the artificial air capture of carbon dioxide, and he invented the world’s first commercially demonstrated direct air capture units. From 2001 to 2014, Klaus served as the director of the Lenfest Center for Sustainable Energy, and his work has been featured in The New Yorker, Scientific Americanand the Washington Post. Today, Klaus joins Ross, Christophe and Paul to offer his feedback on the Nori whitepaper. Klaus explains why he likes the idea of breaking the carbon offset model and offering compensation based on actual carbon removed. He also shares his concerns around Nori’s customers, the verification challenges they face, and the issue of permanency. Listen in for spirited debate on retiring certificates in compliance markets and the potential decrease in value of Nori tokens as less expensive methods for collecting CO2 emerge. Resources Klaus on RCC EP07 COMET-Farm Coinbase Key Takeaways [1:58] What Klaus likes about the Nori whitepaper Breaks model of carbon offsets Nori pays for actual removal Incentives better than market for mitigation Allows for balancing of carbon budget [5:43] Klaus’ questions around Nori’s customers Compliance market vs. volunteers Start with large buyers (i.e.: corporations) Transition to microtransactions in high volume [9:42] The verification challenge Nori faces Must work out standards method by method Baseline only works in certain class of applications [13:18] Klaus’ concerns over the permanency issue Existing markets require farmers to maintain practices for up to 100 years, only compensated for 20 Nori working with COMET-farm to determine minimum time before farmers will continue regardless [15:55] The categories of methodologies Ecological, industrial and hybrid One CRC = one metric ton of carbon removed (+/-10%) [19:01] Klaus’ reservations around retiring certificates CRC created with verification of carbon removal CRC non-transferrable as soon as purchased Compliance markets would accept CRCs (not tokens) [24:22] The regulatory gray area of cryptocurrency Categorized as money, property and securities Clarification necessary to ensure compliance [26:45] Klaus’ concerns around market equilibrium Currency devalued as technology improves (cheaper to remove carbon) Encourages competition to increase profit margins Price at market level comes down with competition
Verity for Breakfast Catchup - Triple M Central Wheatbelt 1098
Senior Sergeant from the Merredin Police filled us in on the cases of vandals causing damage in town, both at the Pioneer Cemetery and at the Vietnam War Memorial in Roy Little Park, there is good news in that the culprits have been found. Whilst Regional Development Minister Alannah MacTiernan was in town, the question of funding cuts to CRCs couldn't be avoided and she has said cuts need to be made to cater for “really, really important” investments. Avon Footy Association preview for Round 5 with Macca this morning, a big congratulations and good luck to Brad Jones going in to play his 250th game this week. World According to Quinny- More great sporting news about representatives from our region, an orchestral band from the Wheatbelt has just returned from the concrete jungle of NY and the Northam Women in Business have a wonderful opportunity available at the moment.
Verity for Breakfast Catchup - Triple M Central Wheatbelt 1098
Our WA Government has announced plans to cut $5 million in funding from our CRCs which will likely see operating hours cut and opportunities for trainees restricted. Aunty Fil gives her 2 cents this morning. Yongah Hill Immigration Detention Centre in our Avon Valley, Northam, has recorded the highest number of escape attempts in Australia... I think I might hold the record of most voicemails collected, the call is out there for anyone who's beaten my record. Under the Lino this morning- local history gem regarding the post office an, the discovery of Freo and 9-5 hits the charts.
Verity for Breakfast Catchup - Triple M Central Wheatbelt 1098
Eliza Wynn from the Avon Valley and Wheatbelt Advocate let us know about a new restaturant that is to be set up in the main street of Northam, we recently had successful graduated from our regional TAFE program and lastly we touched on the big issue lately which is the government cuts to our Community Resource Centres. Released on this date in 1974, The Great Gatsby was the film for Johns' Retro Review this morning, as always he gives us some great fun facts about the film you might not know about :) Tina Pendlebury from the Cancer Council WA came on this morning to let us know about all the wonderful anniversaries we've got going on this year as well as some statistics as to how the fundraising goes back to families to need help from the Central Wheatbelt and Avon Valley. Kirra from our St John Ambulance Wheatbelt hub had a chat with me this morning about safety in the lead up to this long Easter weekend and also the fact that we do also seem to have a few snakes around the place.
In the beginning… Paul and Christophe realized that the blockchain provides an ideal platform for a carbon marketplace where people can get paid to remove CO2 from the atmosphere—and ultimately succeed in reversing climate change. It took more than six days, but they eventually put together a team, developed a business plan, and Nori was born. The bottom line is that we need to remove 1.5 trillion tonnes of carbon dioxide from the atmosphere to get back to safe levels. The Nori team intends to make that happen by connecting people interested in paying for carbon offsets with people who are using any number of methods to remove carbon from the atmosphere. One Nori token purchases one ton of carbon removal credits (CRCs), and the company measures the removal of CO2 and records that information on the blockchain. Ultimately, Nori leverages the power of markets to pay individuals who are innovating in the area of carbon removal and treat the root cause of climate change—too much carbon in the atmosphere. Today, Ross, Christophe and Paul are sharing the details of Nori’s role in reversing climate change, explaining the company’s principal aims, how Nori addresses the problems associated with current carbon removal markets, and how cryptocurrency figures into their plans. They walk us through Nori’s core values and their current progress in developing the platform. Listen in for the Norigin story and learn how the team is preparing to launch in 2018. Resources Simon Sinek’s TED Talk ASU Center for Negative Carbon Emissions The Big Short: Inside the Doomsday Machine by Michael Lewis ConsenSys Key Takeaways [0:50] Nori’s purpose Build market mechanism that pays to remove CO2 from atmosphere [1:17] Nori’s role in reversing climate change Provide financing, incentives to facilitate large-scale carbon removal Measure and verify CO2 removal, record on blockchain [5:02] The cryptocurrency element of Nori’s plan One Nori token purchases one ton of carbon removal credits Represents universal price on carbon removal [6:49] The problems that Nori addresses Offsets sell for different prices Issues of double-counting Trust barrier No-cost payment methodology [9:09] Nori’s core values Open-sourced methodology Remove carbon AND maintain energy use, quality of life Create mechanism to reduce emissions (no favorites) Put price on carbon removal, leverage power of markets [12:30] How Nori came about Paul looking into climate change, started Carbon Removal Seattle Reached out to ASU Center for Negative Carbon Emissions Connected with Christophe, started Carbon Removal Society Christophe started Carbon A List, met Paul at conference Paul and Jaycen competed in Hackathon with Carbon Harvest Christophe moved to Seattle, worked with Paul on idea Entered month-long ConsenSys business planning competition Won in energy and environment category, founded company Hosting summit at end of April to demo prototype Plans to launch platform and token together in 2018 [25:10] The important issues Nori is working on Monetary economics to stabilize supply/demand Auditing system to disincentivize cheating Getting the word out (i.e.: eBook, podcast and whitepaper) [27:39] Nori’s current progress Developers creating platform, designing token Redesign of website
When we think of green buildings, we typically think of operational efficiency. But what if the building process itself was greener? What if we used local building materials that didn’t have to be transported? And what if we sequestered carbon from the atmosphere and used it in the building materials themselves? Andrew Himes is a partner at Carbon Innovations, currently working with the University of Washington’s Carbon Smart Building Initiative. The project seeks to transform the built environment from an existential threat to a net carbon sink that absorbs more than a billion tons of CO2 each year by converting captured carbon into useful building products and creating market demand for carbon capture. Andrew has a background in activism and technology, serving as the founding editor for MacTech and co-founding the Microsoft Developer Network before becoming a nonprofit startup specialist. Today he joins Ross and Christophe to share the vision of the Embodied Carbon Network, explaining the concept of embodied carbon emissions and the necessity of accelerating their reduction. We discuss the challenges around motivating people to adopt carbon removal practices and validating that carbon was, indeed, removed efficiently and permanently. Listen in to understand how the blockchain could facilitate the reduction of embodied carbon and learn how the Carbon Smart Building Initiative is leading the global effort to rethink how we interact with each other and the Earth. Key Takeaways [2:21] How Andrew’s background led to his work with Carbon Innovations Civil rights, anti-war activist Founded MacTech magazine Cofounded Microsoft Developer Network Created Charter for Compassion International Mission to capture carbon, put into products [8:36] The Carbon Smart Building Initiative Considers embodied carbon emissions required to build Carbon captured and utilized in building materials [11:15] Andrew’s vision for transforming the built environment Includes roads, ports, bridges and buildings Accounts for 40% of all greenhouse gas emissions Only five of 2038’s 20 biggest cities exist today Carbon net zero in every new building Sequester 1B tons of carbon each year Existing buildings refitted for operational efficiency [16:32] The definition of embodied carbon Accounting technique for sum impact of emissions attributed to building materials Includes extraction, manufacturing, construction, maintenance and disposal [19:28] Andrew’s take on what motivates people Decisions based on ethics, beauty/comfort and economics ‘Carbon handprint’ gives agency to actively create solution [26:10] Andrew’s insight around the challenges of creating a carbon removal marketplace Validating numbers, verify carbon removed effectively/permanently Designing mechanism to measure stored carbon in built environment [30:01] The monetization of carbon removal Companies advertise importance of reducing emissions, but don’t track Nori could provide marketplace for companies earning CRCs [33:46] The challenges of the Embodied Carbon Network Building of any kind emits carbon Local sourcing of materials [36:07] How the blockchain might help facilitate the reduction of embodied carbon Life cycle inventory open source database available to all Thousands could contribute to add data, improve analysis Measure, validate carbon sequestration through entire supply chain [42:53] Andrew’s aspiration for a hopeful future Global effort to rethink how interact with each other, Earth Supporting leadership/freedom of women would reduce climate change Resources Carbon Leadership Forum Embodied Carbon Network LEED Life Cycle Assessment by Kate Simonen Climate of Hope by Michael Bloomberg and Carl Pope DRAWDOWN: The Most Comprehensive Plan Ever Proposed to Reverse Global Warming by Paul Hawken
This week on the show, we've got some great stories to bring you, a look at the odder side of UNIX history This episode was brought to you by Headlines syspatch in testing state (http://marc.info/?l=openbsd-tech&m=148058309126053&w=2) Antoine Jacoutot ajacoutot@ openbsd has posted a call for testing for OpenBSD's new syspatch tool “syspatch(8), a "binary" patch system for -release is now ready for early testing. This does not use binary diffing to update the system, but regular signed tarballs containing the updated files (ala installer).” “I would appreciate feedback on the tool. But please send it directly to me, there's no need to pollute the list. This is obviously WIP and the tool may or may not change in drastic ways.” “These test binary patches are not endorsed by the OpenBSD project and should not be trusted, I am only providing them to get early feedback on the tool. If all goes as planned, I am hoping that syspatch will make it into the 6.1 release; but for it to happen, I need to know how it breaks your systems :-)” Instructions (http://syspatch.openbsd.org/pub/OpenBSD/6.0/syspatch/amd64/README.txt) If you test it, report back and let us know how it went *** Weston working (https://lists.freebsd.org/pipermail/freebsd-current/2016-December/064198.html) Over the past few years we've had some user-interest in the state of Wayland / Weston on FreeBSD. In the past day or so, Johannes Lundberg has sent in a progress report to the FreeBSD mailing lists. Without further ADO: We had some progress with Wayland that we'd like to share. Wayland (v1.12.0) Working Weston (v1.12.0) Working (Porting WIP) Weston-clients (installed with wayland/weston port) Working XWayland (run X11 apps in Wayland compositor) Works (maximized window only) if started manually but not when launching X11 app from Weston. Most likely problem with Weston IPC. Sway (i3-compatible Wayland compositor) Working SDL20 (Wayland backend) games/stonesoup-sdl briefly tested. https://twitter.com/johalun/status/811334203358867456 GDM (with Wayland) Halted - depends on logind. GTK3 gtk3-demo runs fine on Weston (might have to set GDK_BACKEND=wayland first. GTK3 apps working (gedit, gnumeric, xfce4-terminal tested, xfce desktop (4.12) does not yet support GTK3)“ Johannes goes on to give instructions on how / where you can fetch their WiP and do your own testing. At the moment you'll need Matt Macy's newer Intel video work, as well as their ports tree which includes all the necessary software bits. Before anybody asks, yes we are watching this for TrueOS! *** Where the rubber meets the road (part two) (https://functionallyparanoid.com/2016/12/15/where-the-rubber-meets-the-road-part-two/) Continuing with our story from Brian Everly from a week ago, we have an update today on the process to dual-boot OpenBSD with Arch Linux. As we last left off, Arch was up and running on the laptop, but some quirks in the hardware meant OpenBSD would take a bit longer. With those issues resolved and the HD seen again, the next issue that reared its head was OpenBSD not seeing the partition tables on the disk. After much frustration, it was time to nuke and pave, starting with OpenBSD first this time. After a successful GPT partitioning and install of OpenBSD, he went back to installing Arch, and then the story got more interesting. “I installed Arch as I detailed in my last post; however, when I fired up gdisk I got a weird error message: “Warning! Disk size is smaller than the main header indicates! Loading secondary header from the last sector of the disk! You should use ‘v' to verify disk integrity, and perhaps options on the expert's menu to repair the disk.” Immediately after this, I saw a second warning: “Caution: Invalid backup GPT header, but valid main header; regenerating backup header from main header.” And, not to be outdone, there was a third: “Warning! Main and backup partition tables differ! Use the ‘c' and ‘e' options on the recovery & transformation menu to examine the two tables.” Finally (not kidding), there was a fourth: “Warning! One or more CRCs don't match. You should repair the disk!” Given all of that, I thought to myself, “This is probably why I couldn't see the disk properly when I partitioned it under Linux on the OpenBSD side. I'll let it repair things and I should be good to go.” I then followed the recommendation and repaired things, using the primary GPT table to recreate the backup one. I then installed Arch and figured I was good to go.“ After confirming through several additional re-installs that the behavior was reproducible, he then decided to go full on crazy,and partition with MBR. That in and of itself was a challenge, since as he mentions, not many people dual-boot OpenBSD with Linux on MBR, especially using luks and lvm! If you want to see the details on how that was done, check it out. The story ends in success though! And better yet: “Now that I have everything working, I'll restore my config and data to Arch, configure OpenBSD the way I like it and get moving. I'll take some time and drop a note on the tech@ mailing list for OpenBSD to see if they can figure out what the GPT problem was I was running into. Hopefully it will make that part of the code stronger to get an edge-case bug report like this.” Take note here, if you run into issues like this with any OS, be sure to document in detail what happened so developers can explore solutions to the issue. *** FreeBSD and ZFS as a time capsule for OS X (https://blog.feld.me/posts/2016/12/using-freebsd-as-a-time-capsule-for-osx/) Do you have any Apple users in your life? Perhaps you run FreeBSD for ZFS somewhere else in the house or office. Well today we have a blog post from Mark Felder which shows how you can use FreeBSD as a time-capsule for your OSX systems. The setup is quite simple, to get started you'll need packages for netatalk3 and avahi-app for service discovery. Next up will be your AFP configuration. He helpfully provides a nice example that you should be able to just cut-n-paste. Be sure to check the hosts allow lines and adjust to fit your network. Also of note will be the backup location and valid users to adjust. A little easier should be the avahi setup, which can be a straight copy-n-paste from the site, which will perform the service advertisements. The final piece is just enabling specific services in /etc/rc.conf and either starting them by hand, or rebooting. At this point your OSX systems should be able to discover the new time-capsule provider on the network and DTRT. *** News Roundup netbenches - FreeBSD network forwarding performance benchmark results (https://github.com/ocochard/netbenches) Olivier Cochard-Labbé, original creator of FreeNAS, and leader of the BSD Router Project, has a github repo of network benchmarks There are many interesting results, and all of the scripts, documentation, and configuration files to run the tests yourself IPSec Performance on an Atom C2558, 12-head vs IPSec Performance Branch (https://github.com/ocochard/netbenches/tree/master/Atom_C2558_4Cores-Intel_i350/ipsec/results/fbsd12.projects-ipsec.equilibrium) Compared to: Xeon L5630 2.13GHz (https://github.com/ocochard/netbenches/tree/2f3bb1b3c51e454736f1fcc650c3328071834f8d/Xeon_L5630-4Cores-Intel_82599EB/ipsec/results/fbsd11.0) and IPSec with Authentication (https://github.com/ocochard/netbenches/tree/305235114ba8a3748ad9681c629333f87f82613a/Atom_C2558_4Cores-Intel_i350/ipsec.ah/results/fbsd12.projects-ipsec.equilibrium) I look forward to seeing tests on even more hardware, as people with access to different configurations try out these benchmarks *** A tcpdump Tutorial and Primer with Examples (https://danielmiessler.com/study/tcpdump/) Most users will be familiar with the basics of using tcpdump, but this tutorial/primer is likely to fill in a lot of blanks, and advance many users understanding of tcpdump “tcpdump is the premier network analysis tool for information security professionals. Having a solid grasp of this über-powerful application is mandatory for anyone desiring a thorough understanding of TCP/IP. Many prefer to use higher level analysis tools such as Wireshark, but I believe this to usually be a mistake.” tcpdump is an important tool for any system or network administrator, it is not just for security. It is often the best way to figure out why the network is not behaving as expected. “In a discipline so dependent on a true understanding of concepts vs. rote learning, it's important to stay fluent in the underlying mechanics of the TCP/IP suite. A thorough grasp of these protocols allows one to troubleshoot at a level far beyond the average analyst, but mastery of the protocols is only possible through continued exposure to them.” Not just that, but TCP/IP is a very interesting protocol, considering how little it has changed in its 40+ year history “First off, I like to add a few options to the tcpdump command itself, depending on what I'm looking at. The first of these is -n, which requests that names are not resolved, resulting in the IPs themselves always being displayed. The second is -X, which displays both hex and ascii content within the packet.” “It's also important to note that tcpdump only takes the first 96 bytes of data from a packet by default. If you would like to look at more, add the -s number option to the mix, where number is the number of bytes you want to capture. I recommend using 0 (zero) for a snaplength, which gets everything.” The page has a nice table of the most useful options It also has a great primer on doing basic filtering If you are relatively new to using tcpdump, I highly recommend you spend a few minutes reading through this article *** How Unix made it to the top (http://minnie.tuhs.org/pipermail/tuhs/2016-December/007519.html) Doug McIlroy gives us a nice background post on how “Unix made it to the top” It's fairly short / concise, so I felt it would be good to read in its entirety. “It has often been told how the Bell Labs law department became the first non-research department to use Unix, displacing a newly acquired stand-alone word-processing system that fell short of the department's hopes because it couldn't number the lines on patent applications, as USPTO required. When Joe Ossanna heard of this, he told them about roff and promised to give it line-numbering capability the next day. They tried it and were hooked. Patent secretaries became remote members of the fellowship of the Unix lab. In due time the law department got its own machine. Less well known is how Unix made it into the head office of AT&T. It seems that the CEO, Charlie Brown, did not like to be seen wearing glasses when he read speeches. Somehow his PR assistant learned of the CAT phototypesetter in the Unix lab and asked whether it might be possible to use it to produce scripts in large type. Of course it was. As connections to the top never hurt, the CEO's office was welcomed as another ouside user. The cost--occasionally having to develop film for the final copy of a speech--was not onerous. Having teethed on speeches, the head office realized that Unix could also be useful for things that didn't need phototypesetting. Other documents began to accumulate in their directory. By the time we became aware of it, the hoard came to include minutes of AT&T board meetings. It didn't seem like a very good idea for us to be keeping records from the inner sanctum of the corporation on a computer where most everybody had super-user privileges. A call to the PR guy convinced him of the wisdom of keeping such things on their own premises. And so the CEO's office bought a Unix system. Just as one hears of cars chosen for their cupholders, so were theseusers converted to Unix for trivial reasons: line numbers and vanity.“ Odd Comments and Strange Doings in Unix (http://orkinos.cmpe.boun.edu.tr/~kosar/odd.html) Everybody loves easter-eggs, and today we have some fun odd ones from the history throughout UNIX told by Dennis Ritchie. First up, was a fun one where the “mv” command could sometimes print the following “values of b may give rise to dom!” “Like most of the messages recorded in these compilations, this one was produced in some situation that we considered unlikely or as result of abuse; the details don't matter. I'm recording why the phrase was selected. The very first use of Unix in the "real business" of Bell Labs was to type and produce patent applications, and for a while in the early 1970s we had three typists busily typing away in the grotty lab on the sixth floor. One day someone came in and observed on the paper sticking out of one of the Teletypes, displayed in magnificent isolation, this ominous phrase: values of b may give rise to dom! It was of course obvious that the typist had interrupted a printout (generating the "!" from the ed editor) and moved up the paper, and that the context must have been something like "varying values of beta may give rise to domain wall movement" or some other fragment of a physically plausible patent application.But the phrase itself was just so striking! Utterly meaningless, but it looks like what... a warning? What is "dom?" At the same time, we were experimenting with text-to-voice software by Doug McIlroy and others, and of course the phrase was tried out with it. For whatever reason, its rendition of "give rise to dom!" accented the last word in a way that emphasized the phonetic similarity between "doom" and the first syllable of "dominance." It pronounced "beta" in the British style, "beeta." The entire occurrence became a small, shared treasure.The phrase had to be recorded somewhere, and it was, in the v6 source. Most likely it was Bob Morris who did the deed, but it could just as easily have been Ken. I hope that your browser reproduces the b as a Greek beta.“ Next up is one you might have heard before: /* You are not expected to understand this */> Every now and then on Usenet or elsewhere I run across a reference to a certain comment in the source code of the Sixth Edition Unix operating system. I've even been given two sweatshirts that quote it. Most probably just heard about it, but those who saw it in the flesh either had Sixth Edition Unix (ca. 1975) or read the annotated version of this system by John Lions (which was republished in 1996: ISBN 1-57298-013-7, Peer-to-Peer Communications).It's often quoted as a slur on the quantity or quality of the comments in the Bell Labs research releases of Unix. Not an unfair observation in general, I fear, but in this case unjustified. So we tried to explain what was going on. "You are not expected to understand this" was intended as a remark in the spirit of "This won't be on the exam," rather than as an impudent challenge. There's a few other interesting stories as well, if the odd/fun side of UNIX history at all interests you, I would recommend checking it out. Beastie Bits With patches in review the #FreeBSD base system builds 100% reproducibly (https://twitter.com/ed_maste/status/811289279611682816) BSDCan 2017 Call for Participation (https://www.freebsdfoundation.org/news-and-events/call-for-papers/bsdcan-2017/) ioCell 2.0 released (https://github.com/bartekrutkowski/iocell/releases) who even calls link_ntoa? (http://www.tedunangst.com/flak/post/who-even-calls-link-ntoa) Booting Androidx86 under bhyve (https://twitter.com/pr1ntf/status/809528845673996288) Feedback/Questions Chris - VNET (http://pastebin.com/016BfvU9) Brian - Package Base (http://pastebin.com/8JJeHuRT) Wim - TrueOS Desktop All-n-one (http://pastebin.com/VC0DPQUF) Daniel - Long Boots (http://pastebin.com/q7pFu7pR) Bryan - ZFS / FreeNAS (http://pastebin.com/xgUnbzr7) Bryan - FreeNAS Security (http://pastebin.com/qqCvVTLB) ***
Medizinische Fakultät - Digitale Hochschulschriften der LMU - Teil 18/19
The intestine is a pivotal organ which is divided into two anatomical parts: the small intestine and the large intestine (colon and rectum). Both parts are made up of single layered epithelium. This epithelium is composed of villi (protrusions) – found only in the small intestine - and crypts (invaginations) leading to an increase of the surface of the intestinal lumen whereby the uptake of nutrients and water is improved. Every five days, the intestinal epithelium is renewed whereby both, crypts and eventually villi, are filled up with new cells. The homeostasis of the crypts/villi relies on adult stem cells (SCs), especially crypt base columnar (CBC) cells, which are located at the base of the crypts. These are regulated by an active Wnt signaling pathway. A deregulation of the Wnt signaling pathway leads to cancer formation found in humans almost exclusively in the colon and rectum. Colorectal cancer (CRC) is worldwide the third most common cause for cancer related deaths. In the majority of CRC, origin and progress are caused by mutations in the adenomatous polyposis coli (APC) gene which encodes an essential component of the β-catenin destruction complex that is the central element of the Wnt signaling pathway. As a consequence of these mutations, the executor of the Wnt signaling pathway, β-catenin, which is in this context a transcription factor, cannot be downregulated any more. As a consequence target genes of β-catenin are expressed in an unregulated manner. These target genes regulate features of stem cell biology which confer cancer stemness, metastasis, EMT (epithelial-mesenchymal transition), chemoresistance and other characteristics to colorectal tumor cells. Interestingly, APC mutations have only an effect when they occur in the adult stem cells. Thus, the descendend tumor cells show characteristics of these cells and have been termed cancer stem cells (CSCs). Like adult stem cells in the normal crypt CSCs are the origin of cancer and are characterized by an activated - here deregulated - Wnt signaling pathway and thus, by the aforementioned features. Clinically, cancer death is caused in most cases by metastasis which is treated by chemotherapy from which most if not all CRCs escape by the development of chemoresistance which is an intrinsic feature of the CSCs. Therefore, CSC specific targeted therapies might be a promising therapeutic tool for a successful treatment of CRCs. One possibility is the interference of CSC sustaining molecules as these molecules are involved in the induction and maintenance of CSCs. Here, a promising molecule is olfactomedin-4 (OLFM4) which was discussed to be a CSC marker. But the role of OLFM4 as a CSC marker and important factor for tumorigenesis has been controversially described. Therefore, I investigated in the first part of my thesis the role of OLFM4 in CRC cells. I demonstrate that OLFM4 was expressed only in two out of 14 CRC cell lines. The assumption that OLFM4 was only expressed in cells with characteristics of CSCs and thus, was not detected in the cell lines as they possess only a small proportion of CSCs, was not confirmed. I found that CSCs showed a reduced OLFM4 expression and thus, OLFM4 was not coexpressed with other SC markers. These results indicate that OLFM4 is not a marker of CSCs in CRC. In order to analyze the functional role of OLFM4 in CRC cells, I overexpressed OLFM4 lentivirally. However, the overexpression of OLFM4 and thus, high OLFM4 protein levels did not influence the expression of CSC, EMT or differentiation marker. Likewise, OLFM4 did not play a functional role for proliferation, stemness and metastatic features. Therefore, this study demonstrates that OLFM4 is not a CSC marker and has no functional role for the driving activity in the process of colorectal carcinogenesis. Additionally, I evaluated in the second part of my thesis the role of the microRNAome (miRNAome) in colorectal carcinogenesis, the influence on CSC features and whether the miRNAome might be a tool for specific CSC targeted therapies. microRNAs (miRNAs) are generally downregulated in tumors whereby the miRNA loss promotes tumorigenesis. As the majority of the CRC cases are driven by an APC mutation in the SC compartment, I used for my investigations a mouse model with a conditional Apc knockout in CBC cells which develops efficiently intestinal adenomas. This mouse model was crossed with another mouse model harboring a conditional knockout of the essential miRNA generator Dicer1 to investigate the role of a loss of the miRNAome in murine Wnt driven intestinal tumors. In this part of my study I demonstrated that hetero- and homozygous deletion of Dicer1 in CBC cells, in combination with an Apc knockout, enhances significantly the number of adenomas. Moreover, deletion of Dicer1 resulted in smaller adenomas caused by reduced proliferation. Further analysis of DICER1 deletion in human CRC cell lines revealed that loss of DICER1 and thus, miRNAs led likewise to a decreased proliferation. Additionally, I showed that loss of miRNAs increased the expression/protein levels of CSC markers and CSC features indicating that loss of DICER1 promotes tumorigenesis. Moreover, I translated these mouse model/cell culture results into human colonic normal and tumor tissue as well as CRC. In a collection of different tissues (normal tissue, adenomas and cancers of stages I to IV), increased DICER1 levels were seen from normal tissue to adenomas followed by decreased levels during carcinoma progression. Increased levels of DICER1 were also found in the murine Wnt driven adenomas. In support with this I provided finally evidence that DICER1 expression is regulated by the Wnt signaling pathway thus already early in the beginning of the colorectal tumorigenesis. Thus, this data showed that DICER1 is a tumor suppressor in intestinal cancer and the loss of DICER1 and hence, of the miRNAome, influences CSC marker expression and marker protein levels as well as proliferation and CSC features. Therefore, the miRNAome might possibly become a therapeutic target for CSC targeted therapy.
Background: Genetically, colorectal cancers (CRCs) can be subdivided into tumors with chromosomal instability (CIN) or microsatellite instability (MSI). In both types of CRCs genes that are involved in the degradation of beta-CATENIN are frequently mutated. Whereas in CIN CRCs APC (Adenomatous Polyposis Coli) is affected in most cases, high grade MSI (MSI-H) CRCs frequently display mutations in various genes, like the APC-, AXIN2- or CTNNBI (beta-CATENIN) gene itself. Recently in Wilms tumors, WTX (Wilms tumor gene on the X-chromosome) was discovered as another gene involved in the destruction of beta-CATENIN. As the WTX-gene harbors a short T(6)-microsatellite in its N-terminal coding region, we hypothesized that frameshift-mutations might occur in MSI-H CRCs in the WTX gene, thus additionally contributing to the stabilization of beta-CATENIN in human CRCs. Methods: DNA was extracted from 632 formalin-fixed, paraffin-embedded metastatic CRCs (UICCIV) and analyzed for MSI-H by investigating the stability of the highly sensitive microsatellite markers BAT25 and BAT26 applying fluorescence capillary electrophoresis (FCE). Then, in the MSI-H cases, well described mutational hot spot regions from the APC-, AXIN2- and CTNNBI genes were analyzed for genomic alterations by didesoxy-sequencing while the WTX T(6)-microsatellite was analyzed by fragment analysis. Additionally, the PCR products of T(5)-repeats were subcloned and mutations were validated using didesoxy-sequencing. Furthermore, the KRAS and the BRAF proto-oncogenes were analyzed for the most common activating mutations applying pyro-sequencing. mRNA expression of WTX from MSI-H and MSS cases and a panel of colorectal cancer cell lines was investigated using reverse transcription (RT-) PCR and FCE. Results: In our cohort of 632 metastatic CRCs (UICCIV) we identified 41 MSI-H cases (6.5%). Two of the 41 MSI-H cases (4.8%) displayed a frameshift mutation in the T(6)-repeat resulting in a T(5) sequence. Only one case, a male patient, expressed the mutated WTX gene while being wild type for all other investigated genes. Conclusion: Mutations in the WTX-gene might compromise the function of the beta-CATENIN destruction complex in only a small fraction of MSI-H CRCs thus contributing to the process of carcinogenesis.
Background: Hereditary nonpolyposis colorectal cancer (HNPCC) is an autosomal dominant disorder predisposing to predominantly colorectal cancer (CRC) and endometrial cancer frequently due to germline mutations in DNA mismatch repair (MMR) genes, mainly MLH1, MSH2 and also MSH6 in families seen to demonstrate an excess of endometrial cancer. As a consequence, tumors in HNPCC reveal alterations in the length of simple repetitive genomic sequences like poly-A, poly-T, CA or GT repeats (microsatellites) in at least 90% of the cases. Aim of the Study: The study cohort consisted of 25 HNPCC index patients ( 19 Amsterdam positive, 6 Bethesda positive) who revealed a microsatellite stable (MSS) - or low instable (MSI-L) - tumor phenotype with negative mutation analysis for the MMR genes MLH1 and MSH2. An extended marker panel (BAT40, D10S197, D13S153, D18S58, MYCL1) was analyzed for the tumors of these patients with regard to three aspects. First, to reconfirm the MSI-L phenotype found by the standard panel; second, to find minor MSIs which might point towards an MSH6 mutation, and third, to reconfirm the MSS status of hereditary tumors. The reconfirmation of the MSS status of tumors not caused by mutations in the MMR genes should allow one to define another entity of hereditary CRC. Their clinical features were compared with those of 150 patients with sporadic CRCs. Results: In this way, 17 MSS and 8 MSI-L tumors were reclassified as 5 MSS, 18 MSI-L and even 2 MSI-H ( high instability) tumors, the last being seen to demonstrate at least 4 instable markers out of 10. Among all family members, 87 malignancies were documented. The mean age of onset for CRCs was the lowest in the MSI-H-phenotyped patients with 40.5 +/- 4.9 years (vs. 47.0 +/- 14.6 and 49.8 +/- 11.9 years in MSI-L- and MSS-phenotyped patients, respectively). The percentage of CRC was the highest in families with MSS-phenotyped tumors (88%), followed by MSI-L-phenotyped ( 78%) and then by MSI-H-phenotyped (67%) tumors. MSS tumors were preferentially localized in the distal colon supposing a similar biologic behavior like sporadic CRC. MSH6 mutation analysis for the MSI-L and MSI-H patients revealed one truncating mutation for a patient initially with an MSS tumor, which was reclassified as MSI-L by analyzing the extended marker panel. Conclusion: Extended microsatellite analysis serves to evaluate the sensitivity of the reference panel for HNPCC detection and permits phenotype confirmation or upgrading. Additionally, it confirms the MSS status of hereditary CRCs not caused by the common mutations in the MMR genes and provides hints to another entity of hereditary CRC. Copyright (C) 2004 S. Karger AG, Basel.