Podcasts about lhb

This study identifies the Median Raphe Nucleus (MRN)

Segment 1 – News and Notes – Trades and Signings1.The Mets sign Juan Soto to a 15-year, $765 million deal. This made National News all over the country. It was Shohei Ohtani all over again. It was great for baseball, I think. Although, a lot of people were appalled at just the sheer money involved.a.Your thoughtsb.Stat line for 2025: HR, RBI, and BAc.Soto wasn't too effusive in his comments about the Yankees. I wonder if there is anything to read into that.2.The Yankees signed Max Fried to an 8-year, $218 million deal.a.The Yankees have a strong rotation with Cole, Rodon, Fried, Stroman, Gil, and Clarke Schmidt. Your thoughts.b.Stat line for 2025: Wins, IP, ERA, strikeouts3.The Blue Jays acquire Andres Gimenez and RHP Nick Sandlin from the Guardians for 1B/2B Spencer Horwitz and OF Nick Mitchella.It feels like a salary dump for the Guardians, which I found amusing as it came on the heels of the Soto deal. The gulf between the haves and have-nots is getting wider.b.Does this make enough of a difference for the Blue Jays over the next couple of seasons?c.It appears that the Guardians are clearing the path for Travis Bazanna. Date we will see him in Cleveland?4.The Guardians then spin Spencer Horwitz to the Pirates for RHP Luis Ortiz, LHP Josh Hartle, and RHP Michael Kennedy.a.I'm not the biggest fan of the Horwitz, but he makes great contact. But, at first base, I'm not sure. The Pirates need players that get on base. Thoughts?b.Ortiz has a lot of promise. What do you think he can become?5.The Rangers acquire Jake Burger from the Marlins for IF Max Acosta, IF Echedry Vargas, and LHP Brayan Mendoza.a.The Rangers had a down offensive season and needed some pop. I'm not a fan of players like Burger, but he'll hit 30 home runs with ease. How much fantasy improvement is there?b.Who gets the playing time with Burger leaving?6.The Red Sox acquire Garrett Crochet from the White Sox for C Kyle Teel, OF Braden Montgomery, RHP Wikelman Gonzalez, and IF Chase Meidrotha.Now, this was a trade. Thoughts on the deal?b.Crochet is the #10 pitcher off the board. Is this the right spot or does his lack of health give you pause?c.Does Kyle Teel go up on your draft rankings? His current ADP is 621 (41st catcher off the board).d.Chase Meidroth is likely a utility player but had a full-season in Triple-A. Is he worth a late-round grab in Draft and Hold Leagues? He's only been drafted in 11 leagues.7.The Yankees acquire Devin Williams from the Brewers for LHP Nestor Cortes and 2B Caleb Durbin.a.The Yankees shore up the back of the bullpen. When healthy, Williams is great. You were worried about the Yankees closing situation last Sunday. Feel better or does Luke Weaver still save opportunities?b.Cortes is great against LHB but can get hit hard against RHB. I still believe and even more so now that he's moved to the Brewers. Your thoughts?c.Durbin had the great AFL and he's the type of player the Brewers love. Will he get a chance in 2025?8.The Cubs acquire Kyle Tucker from the Astros for 3B Isaac Paredes, RHP Hayden Wesneski, and 3B Cam Smith.a.This was another massive trade. What were your impressions when you heard about it? Which side do you like better? Tucker is in his walk year.b.As with the Guardians, this seems to clear a path for another young player: Matt Shaw. Do you like Shaw's setup?c.Who grabs Tucker's playing time in Houston?i.I might take a late flyer on Jacob Melton. He's currently going 705.96 in Draft and Hold Leagues.

In this episode, Rick Carter, chairman of the board at LHB, talks to F&C reporter Brian Johnson. Carter talks about his career journey and his work on sustainable design goals and strategies.

In this episode, Jason Mangan, the new CEO at architecture and engineering firm LHB, talks to F&C reporter Brian Johnson. Mangan discusses his new role with the company, how he became interested in engineering and his vision for LHB.

In this video, we dive into the thrilling yet ultimately debunked rumors that had Toronto Blue Jays fans on the edge of their seats. Speculation about Cody Bellinger potentially joining the Blue Jays sent shockwaves through the baseball community. We explore the initial reports, the excitement building among fans, and the various theories circulating about how Bellinger could transform the Blue Jays' lineup.This begins an interesting conversation about the Blue Jays game plan with the next biggest LHB on the MLB free agent market. Can the Blue Jays land Cody Bellinger? Let's find out right here on Blue Jays Today!Join this channel to get access to perks:https://www.youtube.com/channel/UCG_WmS_YNdmB4vCxu13bSNw/joinBecome a Patron Today!$3 to join the podcast!https://www.patreon.com/BlueJaysToday Follow Us On Social Media:Instagram: https://www.instagram.com/bluejaystodaypodcast/ Nick's Instagram: https://www.instagram.com/nickpaleolog/Adam's Instagram: https://www.instagram.com/adamjpeddle/Twitter: https://twitter.com/TodayJays Listen To Our Audio Podcast:Spotify: https://open.spotify.com/show/5SFlBTECwLiOSM414Ufp4z Apple Podcasts: https://podcasts.apple.com/ca/podcast/blue-jays-today/id1679057098Join Our Discord:Discord: https://discord.gg/KsVp9epD#TorontoBlueJays #BlueJays #BlueJaysNews #FreeAgents #FreeAgency #FreeAgentRumors #MLBRumors #TradeRumors Hosted on Acast. See acast.com/privacy for more information.

Link to bioRxiv paper: http://biorxiv.org/cgi/content/short/2023.07.27.550788v1?rss=1 Authors: Ba, W., Nollet, M., Yu, X., Wong, S., Miao, A., Beckwith, E., Harding, E. C., Ma, Y., Yustos, R., Vyssotski, A., Wisden, W. C., Franks, N. P. Abstract: REM sleep has been hypothesized to promote emotional resilience, but any neuronal circuits mediating this have not been identified. We find that in mice, somatostatin (Som) neurons in the entopeduncular nucleus (EPSom)/internal globus pallidus are predominantly active selectively during REM sleep. This unique REM activity is necessary and sufficient for maintaining normal REM sleep. Inhibiting or exciting EPSom neurons reduced or increased REM sleep duration, respectively. Activation of the sole downstream target of EPSom neurons, Vglut2 cells in the lateral habenula (LHb), increased sleep via the ventral tegmental area (VTA). A simple chemogenetic scheme to periodically inhibit the LHb over 4 days selectively removed a significant amount of cumulative REM sleep. Chronic REM reduction correlated with mice becoming anxious and more sensitive to aversive stimuli. Therefore, we suggest that REM sleep, in part generated by the EP-LHb-VTA circuit identified here, could contribute to stabilizing reactions to habitual aversive stimuli. Copy rights belong to original authors. Visit the link for more info Podcast created by Paper Player, LLC

Rod Babers, Matt Butler and Jeff Howe are back for a show controlled by the listeners. After a two-week hiatus, LHB returns with its first mailbag episode where the guys answer questions sent in by our listeners. The future quarterback battle between Arch Manning and Quinn Ewers, Steve Sarkisian's offensive prowess, how close Sark is to being a top-10 coach in the country and much more get answered by the hosts on the first of two episodes answering listener questions. You can get the latest Longhorn news and analysis at Horns247. To learn more about listener data and our privacy practices visit: https://www.audacyinc.com/privacy-policy Learn more about your ad choices. Visit https://podcastchoices.com/adchoices

Welcome to the PullHitter Podcast, your destination for actionable resources and tools to grind your way to ultimate fantasy baseball success. On this episode I am joined by my friend Dom ( @bullpenguru ) as we discuss his article ⁠Week 6 FAAB: WHOA BIBEE! – Pullhitter Tanner Bibee, Logan Allen, Louie Varland Kutter Crawford, Yonny Chirinos, Luke Weaver Zach McKinstry, Nick Senzel Yennier Cano, Jason Adam, Brad Boxberger, Wil Smith Brandon Woodruff DL Hall FAAB Archetypes: 2-start SP's, LHB facing lots of RHP, being aware of platoons, team contexts, team tendencies and much more to help raise FAAB awareness The market spending in Main Event on a weekly basis, by team and by leagues Support my work and join the Pull Hitter Patreon:https://patreon.com/user?u=32383693&utm_medium=clipboard_copy&utm_source=copyLink&utm_campaign=creatorshare_creator&utm_content=join_link Follow on Twitter:  @pullhitterpod  https://twitter.com/PullHitterPod  @deadpullhitter https://twitter.com/deadpullhitter  Email : pullhitterpodcast@gmail.com  Website: pullhitter.com My link tree with all of my links in one spot: https://linktr.ee/pullhitter Also check out me cohosting the Launch Angle Podcast with Jeff Zimmerman and Rob Silver! https://anchor.fm/robert-dipietro8 Encouraging feedback and comments. Sports dialogue is the best, so tell me what's on your mind! Thanks for listening! If you feel so kind to show some support for the show that would be greatly appreciated! Ratings and reviews are much appreciated if you listen on a platform that allows that- Thanks! (send me a DM on Twitter for #pullhitterswag when you do!) If you enjoyed the remastered edition of Take Me Out To The Ballgame, that was done by my pal Mike Wrocklage and you can find his work under the name Wrack Attack on Spotify, Sound Cloud and Reverb Nation For inquiries on logo and web site design email rodeobot@gmail.com  https://twitter.com/deadpullhitter

Link to bioRxiv paper: http://biorxiv.org/cgi/content/short/2023.02.17.528253v1?rss=1 Authors: Xu, X., Chen, R., Wang, X.-Y., Jia, W.-B., Xu, P.-F., Liu, X.-Q., Zhang, Y., Liu, X.-F., Zhang, Y. Abstract: Chronic stress and chronic pain are two major predisposing factors to trigger depression. Enhanced excitatory input to the lateral habenula (LHb) has been implicated in pathophysiology of depression. However, the contribution of inhibitory transmission remains elusive. Here, we dissect an inhibitory projection from sensory thalamic reticular nucleus (sTRN) to LHb, which is activated by acute aversive stimuli. Repeated activation of the LHb-projecting sTRN neurons prevents CRS-induced depression onset and hyperexcitability of LHb neurons. Moreover, acute inhibition of sTRN-LHb circuit induces depressive-like behaviors in healthy mice, while enhancing this circuit relieves depression induced by both chronic stress and chronic pain. Intriguingly, both neuropathic pain and comorbid pain in chronic stress are unaffected by this pathway. Finally, we dissected sTRN upstream brain regions associated with stress. Together, our study demonstrates an inhibitory sTRN-LHb circuit in establishing and modulating depression, thus shedding light on potential therapeutic targets for preventing or managing depression. Copy rights belong to original authors. Visit the link for more info Podcast created by Paper Player, LLC

We were honored to have the Rays' own @neilsolondz on to talk how culture breeds success, the deep roster from role players to top-level talent, why keeping a core matters, LHB options, intriguing Spring Training players & more! #raysup Support The Pod! Buy A Shirt! Use Promo Code “FLAPPY” for 10% OFF! Spotify: RBLR Sports […]

We were honored to have the Rays' own @neilsolondz on to talk how culture breeds success, the deep roster from role players to top-level talent, why keeping a core matters, LHB options, intriguing Spring Training players & more! #raysup Support The Pod! Buy A Shirt! Use Promo Code “FLAPPY” for 10% OFF! Spotify: RBLR Sports […]

Link to bioRxiv paper: http://biorxiv.org/cgi/content/short/2023.01.09.523312v1?rss=1 Authors: Green, M. V., Gallegos, D. A., Boua, J.-V., Bartelt, L. C., Narayanan, A., West, A. E. Abstract: Glutamatergic projection neurons of the lateral habenula (LHb) drive behavioral state modulation by regulating the activity of midbrain monoaminergic neurons. Identifying circuit mechanisms that modulate LHb output is of interest for understanding control of motivated behaviors. A small population of neurons within the medial subnucleus of the mouse LHb express the GABAergic synthesizing enzyme GAD2, and they can inhibit nearby LHb projection neurons; however, these neurons lack markers of classic inhibitory interneurons and they co-express the vesicular glutamate transporter VGLUT2. To determine the molecular phenotype of these neurons, we genetically tagged the nuclei of GAD2-positive cells and used fluorescence-activated nuclear sorting to isolate and enrich these nuclei for single nuclear RNA sequencing (FANS-snRNAseq). Our data confirm that GAD2+/VGLUT2+ neurons intrinsic to the LHb co-express markers of both glutamatergic and GABAergic transmission and that they are transcriptionally distinct from either GABAergic interneurons or habenular glutamatergic neurons. We identify gene expression programs within these cells that show sex-specific differences in expression and that are implicated in major depressive disorder (MDD), which has been linked to LHb hyperactivity. Finally, we identify the Ntng2 gene encoding the cell adhesion protein Netrin-G2 as a marker of LHb GAD2+/VGLUT+ neurons and a gene product that may contribute to their target projections. These data show the value of using genetic enrichment of rare cell types for transcriptome studies, and they advance understanding of the molecular composition of a functionally important class of GAD2+ neurons in the LHb. Copy rights belong to original authors. Visit the link for more info Podcast created by Paper Player, LLC

Link to bioRxiv paper: http://biorxiv.org/cgi/content/short/2023.01.04.522571v1?rss=1 Authors: Groos, D., Reuss, A. M., Rupprecht, P., Stachniak, T., Han, S., Lewis, C., Sych, Y., Wieckhorst, M., Karayannis, T., Aguzzi, A., Helmchen, F. Abstract: Appropriate evaluation of risk is essential for survival in complex, uncertain environments. Confronted with choosing between a certain (safe) and an uncertain (risky) option, animals of various species show strong preferential traits which are stable across extended periods of time1-8. How such risk preference is encoded in the neural circuitry of the brain remains poorly understood. A candidate brain region is the lateral habenula (LHb), which has been shown to be prominently involved in various value-guided behaviors9-12. Here, using a balanced two-alternative choice task involving risk of loss, we find that neuronal activity in the LHb prior to action selection reflects risk preference and is governed by distinct inputs from hypothalamic subregions. Specifically, by employing multi-fiber photometry and targeted optogenetic perturbations, we identified glutamatergic LHb projections from both lateral and medial hypothalamus (LH/MH) that provide functionally distinct synaptic inputs to the LHb before action selection. Microendoscopic two-photon calcium imaging revealed risk-preference-selective LHb neurons that decreased their selectivity upon chemogenetic silencing of MH but not LH inputs. Finally, optogenetic stimulation of MH- greater than LHb axons evoked both excitatory and inhibitory postsynaptic responses in LHb neurons (indicative of glutamate/GABA co-release for fine-tuned gain control13), whereas LH- greater than LHb projections were purely excitatory. Our results thus reveal functionally distinct hypothalamus-habenula circuits that govern risk preference in situations of economic decision-making. Copy rights belong to original authors. Visit the link for more info Podcast created by Paper Player, LLC

Link to bioRxiv paper: http://biorxiv.org/cgi/content/short/2023.01.02.522528v1?rss=1 Authors: Haniffa, S., Narain, P., Hughes, M., Petkovic, A., Susic, M., Mlambo, V., Chaudhury, D. Abstract: Chronic social stress in mice causes behavioral and physiological changes resulting in perturbed rhythms of body temperature, activity and sleep-wake cycle. To further understand the link between mood disorders and temperature rhythmicity, we measured core body temperature (Tcore) in mice before and after exposure to the chronic social defeat stress (CSDS) paradigm. Our results revealed that Tcore amplitudes of stress resilient and susceptible mice are dampened during exposure to CSDS. However, after exposure to social stress, the temperature amplitude of resilient mice recovered faster than the susceptible mice. There were minimal changes in locomotor activity after stress exposure which correlates with regular rhythmic expression of Prok2, an output signal of the SCN (Suprachiasmatic nucleus). We also investigated the molecular changes associated with these dampened temperature rhythms, and determined the expression levels of thermosensitive genes Cirbp, Rbm3 and Hsf1. Expression of Rbm3 and Cirbp in the LHb (Lateral habenula) were blunted 1 day after CSDS. These molecular rhythms recovered 10 days later such that daytime expression was higher compared to nighttime, similar to stress-naive controls. Hsf1 did not show robust rhythmic expression in the LHb. Copy rights belong to original authors. Visit the link for more info Podcast created by Paper Player, LLC

Link to bioRxiv paper: http://biorxiv.org/cgi/content/short/2022.11.20.517264v1?rss=1 Authors: Li, G., Bo, B., Wang, P., Qian, P., Li, M., Li, Y., Tong, C., Zhang, K., Zhang, B., Jiang, T., Liang, Z., Duan, X. Abstract: The available treatments for depression have substantial limitations, including low response rates and substantial lag time before a response is achieved. We applied deep brain stimulation (DBS) to the lateral habenula (LHb) of two rat models of depression (Wistar Kyoto rats and lipopolysaccharide-treated rats) and observed an immediate (within seconds to minutes) alleviation of depressive-like symptoms with a high response rate. Simultaneous functional magnetic resonance imaging (fMRI) conducted on the same sets of depressive rats used in behavioral tests revealed DBS-induced activation of multiple regions in afferent and efferent circuitry of the LHb. The activation levels of brain regions connected to the medial LHb (M-LHb) was correlated with the extent of behavioral improvements. Rats with more medial stimulation sites in the LHb exhibited greater antidepressant effects than those with more lateral stimulation sites. These results indicated that the antidromic activation of the limbic system and orthodromic activation of the monoaminergic systems connected to the M-LHb played a critical role in the rapid antidepressant effects of LHb-DBS. This study indicates that M-LHb-DBS might act as a valuable, rapid-acting antidepressant therapeutic strategy for treatment-resistant depression and demonstrates the potential of using fMRI activation of specific brain regions as biomarkers to predict and evaluate antidepressant efficacy. Copy rights belong to original authors. Visit the link for more info Podcast created by Paper Player, LLC

Link to bioRxiv paper: http://biorxiv.org/cgi/content/short/2022.11.17.516965v1?rss=1 Authors: Calvigioni, D., Fuzik, J., Le Merre, P., Slashcheva, M., Jung, F., Ortiz, C., Lentini, A., Csillag, V., Graziano, M., Nikolakopoulou, I., Weglage, M., Lazaridis, I., Kim, H., Lenzi, L., Park, H., Reinius, B., Carlen, M., Meletis, K. Abstract: Excitatory projections from the lateral hypothalamic area (LHA) to the lateral habenula (LHb) drive aversive responses. We used Patch-seq guided multimodal classification to define the structural and functional heterogeneity of the LHA- LHb pathway. Our classification identified six glutamatergic neuron types with unique electrophysiological properties, molecular profiles, and projection patterns. We found that genetically-defined LHA-LHb neurons signal distinct aspects of emotional or naturalistic behaviors: Esr1+ LHA-LHb neurons induce aversion, whereas Npy+ LHA-LHb neurons control rearing behavior. Repeated optogenetic drive of Esr1+ LHA-LHb neurons induces a behaviorally persistent aversive state, and large-scale recordings showed a region-specific neural representation of the aversive state in the prelimbic region of the prefrontal cortex. We further found that exposure to unpredictable mild shocks induced a sex- specific sensitivity to develop a stress state in female mice, which was associated with a specific shift in the intrinsic properties of bursting-type Esr1+ LHA-LHb neurons. In summary, we describe the diversity of LHA-LHb neuron types, and provide evidence for the role of Esr1+ neurons in aversion and sexually dimorphic stress sensitivity. Copy rights belong to original authors. Visit the link for more info Podcast created by Paper Player, LLC

It's Game 134 of the 2022 Season and Cleveland Guardians have a rock solid game and beat the Kansas City Royals 4-1. On today's show we're talking about Bieber using his cutter against LHB and RHB, is Bieber in the Cy Young race, the Guardians offense rallying with singles, and naming our MVP on the day. If you want to share your thoughts on the game or anything Cleveland baseball you can find me on Twitter @daveyberris, you can email the show ClevelandBaseballMornings@gmail.com, or leave a message on the anchor app and we'll play it back on the show. Merchandise is now available at https://clevelandbaseballmornings.myspreadshop.com/ for T-shirts, Hoodies, Coffee Mugs, and More!!! Now available on iHeart Radio: https://www.iheart.com/podcast/269-cleveland-baseball-morning-70571254/ Now available on Amazon Music: https://music.amazon.com/podcasts/17e3d70a-dd9e-4ed3-a6fc-2ef5d6f58bb8/Cleveland-Baseball-Mornings-An-Indians-Fan-Podcast --- Send in a voice message: https://anchor.fm/clevelandbaseballmornings/message

Link to bioRxiv paper: http://biorxiv.org/cgi/content/short/2022.08.31.506056v1?rss=1 Authors: Lynn, M. B., Geddes, S., Chahrour, M., Maille, S., Harkin, E., Harvey-Girard, E., Haj-Dahmane, S., Naud, R. B., Beique, J.-C. Abstract: Serotonin (5-HT) neurons in the dorsal raphe nucleus (DRN) receive a diverse constellation of long-range synaptic inputs, yet unifying principles of local circuitry and its dynamics are largely unknown - a crucial component of understanding how 5-HT output controls behavior. Here, we developed a formalism bridging optogenetic, electrophysiological, computational and behavioral strategies to reveal how the dynamics of local circuitry in DRN control the expression of reward associations. Using long-range input from lateral habenula (LHb) to interrogate functional DRN circuitry, we uncover 5-HT1A receptor-mediated local recurrent connections between 5-HT neurons, refuting classical theories of autoinhibition by 5-HT1A receptors. These inhibitory 5-HT connections were slow, stochastic, strongly facilitating, and gated spike output of 5-HT neurons. Targeted physiology and modeling approaches revealed that these functional connectivity features collectively support the emergence of a paradoxical excitation-driven inhibition in response to high frequency LHb activation, and of a winner-take-all computation over protracted timescales. In vivo, we found that optogenetic activation of LHb inputs to DRN transiently disrupted expression of a reward-conditioned response in an auditory conditioning task. In accordance with quantitative model predictions, this disruption occurred exclusively at the conjunction of high frequency LHb activation and high predicted reward value, and was not due to a modulation of the underlying reward association. Thus, we propose that recurrent dynamics in the DRN support a contextual value computation, where stable learned associations are integrated with dynamic environmental inputs to support sharp behavioral state transitions in changing environments. Copy rights belong to original authors. Visit the link for more info Podcast created by PaperPlayer

Show NotesSHARE, COMMENT, AND SUBSCRIBEToday I want to welcome a very special guest and one that is not just a “guest” but a dear friend. A kindred spirit in the body of Christ.Give a GREAT big LCP HELLO to Chris Clarke-Milton of Last Hour Bereans!!Topics Chris will cover:1. The One TRUE CHURCH – is it the Catholic Church?2. Who is Jesus?3. What is the Catechism4. What is the Eucharist5. Catholic church as the beast.Links Used:https://uscatholic.org/articles/201608/was-jesus-a-catholic/https://www.catholic.org/clife/jesus/webelieve.phphttps://catholicmissionarydisciples.com/news/a-personal-relationship-with-jesus-and-the-catholic-churchhttps://www.britannica.com/topic/Eucharisthttps://www.youtube.com/watch?v=OSyTJaTufcwWhere to find LHB:https://www.youtube.com/channel/UCzRCcLCSkBwY-bW1QpFVGNQhttps://rumble.com/user/LastHourBereanshttps://www.facebook.com/groups/Lasthourbereanshttps://www.teepublic.com/user/rapture7https://www.teepublic.com/user/rapture7/mughttps://docs.google.com/document/d/1O6B2qtopgbnNmmHzqtmf3Y9lAUe7x6CqknvHtkrRMNQ/editBooks:https://www.amazon.com/Bible-Prophecy-Enmity-between-seeds/dp/B09K26JFRG/ref=sr_1_2?qid=1653846710&refinements=p_27%3AChristopher+E+Clarke-Milton&s=books&sr=1-2&text=Christopher+E+Clarke-MiltonVideo's LHB to check out regarding some of the falsehoods:https://youtu.be/UNg9wy5y0Zwhttps://youtu.be/RHVLi7yrCfkhttps://www.amazon.com/Genesis-Project-Rise-new-gods/dp/0692910603/ref=sr_1_6?qid=1653846752&refinements=p_27%3AChristopher++E+Clarke-Milton&s=books&sr=1-6&text=Christopher++E+Clarke-MiltonContact LCP:•questions@lifeclipspodcast.com•http://www.lifeclipspodcast.com•https://www.lifeclipspodcast.com/contact•https://www.lifeclipspodcast.com/where-to-listenEquipment Used:•Video Editing used: Wondershare•Microphone: Blue Yeti•Camera: Kyro Pro

QUESTIONS + TIME STAMPS1. How's The Body Feeling After Playing Winterball? (0:01)2. Have I ever Considered Playing Baseball Overseas in Europe, Africa, Asia, or Australia? (2:01)3. I'm Striding Out Farther and it Helped Command But I'm Not Bringing My Back Leg Thru (3:52)4. Counter Rotation is Helping Me Get Separation but Making it Hard to See Target. Tips? (6:36)5. Could Hips Not Being Rotated at Landing Cause Poor Lead Leg Block? (9:41)6. I Bought an Analysis From You, Could I Send you a Video of Me Now and Tell Me How it Looks? (11:24)7. What's The Most Difficult Pitch to Throw (12:06)8. Have you Found That Backfoot Sliders to LHB's are as Lethal as a CH These Days? (12:26)9. Are You Trying To Get to The Big Leagues? (14:05)10. What's a Good Way To Not Open So Early? (14:42)11. I Need Tips For Sliders, I Feel Like I Lost Mine Recently + Can't Find it. (16:22)12. What is The Key To Throwing Hard? (18:59)THE ROBBY ROW SHOW WEBSITEWho is Robby Rowland?https://therobbyrowshow.com/about/Robby Rowland's Social Channelshttps://therobbyrowshow.com/follow-me/The Robby Row Show VLOGhttps://therobbyrowshow.com/vlog/Ask Robby Row Pagehttps://therobbyrowshow.com/ask/ Website Search Enginehttps://therobbyrowshow.com/search/ Partnerships + Discounts on Products I Usehttps://therobbyrowshow.com/productdiscounts/ Robby Row's Content Library https://therobbyrowshow.com/content-library/ The Robby Row Show Baseball Podcasthttps://therobbyrowshow.com/podcast/ Content Creation Products + Podcast Equipmenthttps://therobbyrowshow.com/content-creation/ WHERE YOU CAN FIND ROBBY ROWRobby Row's Social Mediahttps://therobbyrowshow.com/follow-me/ Websitehttps://therobbyrowshow.com YouTube https://youtube.com/c/RobbyRowland Instagram https://www.instagram.com/robbyrow12/ Twitter https://twitter.com/RobbyRow_12 TikTok www.tiktok.com/@robbyrow12Facebook https://www.facebook.com/robbyrow12/ Podcasthttps://therobbyrowshow.com/podcast/ LinkedInwww.linkedin.com/in/robbyrow12 SUBSCRIBE TO MY PODCASTApple Podcast https://itunes.apple.com/us/podcast/the-robby-row-show/id1341507777?mt=2 Spotify Podcast https://open.spotify.com/show/2AEEhbkL1P4YUS4yzpNXOK?si=Qyc6K0JgTO-_LmGX19mwtg iHeart Radio Podcast https://www.iheart.com/podcast/256-the-robby-row-show-30930836/ Stitcherhttps://www.stitcher.com/podcast/robby-rowland/the-robby-row-show DONATIONSPayPalhttps://paypal.me/robbyrow VenmoRobbyrow12

LHB, LHBT, LHBT+, LHBTIQ … Men hvor ender det? Vi ser nærmere på den endeløse transdebatten, på den tårevåte ungdommen, domstols- og regionreformen – og masse annet ræl. På 15 raske minutter. --- Send in a voice message: https://anchor.fm/gubber/message

LaTezeon co-hosts the Rising and Inspiring YouTube Channel and is the author of the children's book Fur Friends Forever.   An educator with many years of experience within the classroom. She has taught on the elementary and secondary levels. LaTezeon worked as an education consultant in MS where she assisted several school districts with professional development and education support in the classroom. Her skills vary from communication, computer, and interpersonal.   She is responsible, goal-oriented, and an expeditious learner. LaTezeon enjoys blogging, marketing and building a social media presence. Her ultimate goal is to find a career where she is able to enhance and develop new skills to expand a company and grow as a person. LaTezeon is highly qualified and goal-oriented with outstanding interpersonal and communication skills. She is passionate about efforts to create more affirmative, structured, caring, and innovating culture for our youth and community. LHB is a mental health advocate and a literacy advocate. She has book giveaways on Twitter and a book scholarship for seniors. A part of her proceeds from her book will go to animal shelters in MS.   Here is the link to our YouTube channel:  https://www.youtube.com/watch?v=_aCnZdTAz_w Twitter account: @LHBLovesEdu Instagram: @LHBLovesEdu LinkedIn: www.linkedin.com/in/latezeon-humphrey-balentine-9875a91a6   Her book: Fur Friends Forever: Follow this amazing adventure of two dogs with different lifestyles as they take on a new situation that tests them. This story is about friendship and all that comes with it including peer pressure in decision making. Enjoy this journey while Abby, Lincoln, and Molly learn the true meaning of care, love, and sacrifice.   -------------------------   This link will take you to ALL of Kelly's social media: https://linktr.ee/kellycroy Sign-up for Kelly's newsletter here. Kelly Croy is an author, speaker, and educator. If you'd like to learn more about Kelly or invite him to your school or conference to speak please send him an email.  Subscribe to The Wired Educator Podcast with 212 episodes of interviews and professional development. • Visit Kelly's website at www.KellyCroy.com. • Looking for a dynamic speaker for your school's opening day? • Consider Kelly Croy at www.KellyCroy.com • Order Kelly's books, Along Came a Leaderand Unthink Before Bed: A Children's Book on Mindfulness for your personal library. • Follow Kelly Croy on Facebook.  • Follow Kelly Croy on Twitter.  •  Follow Kelly Croy on Instagram 

In een samenleving waarin alles mannelijk of vrouwelijk is hebben transgenders vaak een lastig pad te bewandelen. De zoektocht naar hun ware zelf gaat met vallen en opstaan. In het kader van Rotterdam Pride Week gaan we het hebben over transgenders en de reis naar hun transitie. Wij willen alle taboes rondom transgenders verbreken. Waarom is het zo belangrijk dat wij dit bespreekbaar maken?Transgenders hebben vaak te maken met ongelijke behandeling. In theorie hebben transgenders dezelfde rechten als een niet-transgender, maar in de praktijk is dat vaak anders. Zo wordt 43% van de transgenderjongeren die naar school gaan slachtoffer van verbaal geweld. 1/5 van de transgenderjongeren wordt slachtoffer van lichamelijk geweld. Zo werd laatst de 14-jarige Fréderique in elkaar geslagen toen ze niet wilde vertellen of ze een jongen of meisje is. Ervaringsdeskundige Iris Kay In gesprek met ervaringsdeskundigeOnze chick Izzy die zelf in transitie is gaat in gesprek met Iris Kay. Iris is een ervaringsdeskundige op het gebied van transitie en gender. Iris was enkele jaren activist en organiseert nog steeds verschillende activiteiten voor de LHB en Trans gemeenschap. Ze ontving begin dit jaar een prijs van de Stichting Jillis Bruggeman voor het oprichten van een zelforganisatie LHBTI Nissewaard. In deze steungroep worden over verschillende onderwerpen gepraat en soms gaan de deelnemers gezamenlijk koken.  De podcastBen je benieuwd? Beluister de podcast hier terug! De livestream vind je terug op de Facebookpagina of het YouTubekanaal van Chicks And The City.De podcast is onderdeel van Rotterdam Pride dat van 17 t/m 26 september plaatsvindt. Kijk hier voor meer events die tijdens Rotterdam Pride plaatsvinden.

Is subscapularis the forgotten part of the rotator cuff? Do we ever need to target it individually? If we do what are the best options for exercises? Find out which patients with torn or painful shoulders benefit from targeted subscapularis rehab in this episode of the Physio Edge Shoulder success podcast with Jo Gibson. You'll discover: Rotator cuff & subscapularis anatomy & function. Role and function of subscapularis with shoulder movement. How subscapularis works with the posterior cuff and larger shoulder muscles. Subscapularis pain & injury Subscapularis tears - mechanism of injury. Whether subscapularis is implicated in swimmers' shoulder pain. Objective assessment Objective tests to assess subscapularis strength. The role of special tests to identify subscap tears. Targeted subscapularis rehabilitation Which shoulder pain patients require targeted subscapularis rehab. When to target subscap in post-op rehab. Why and how to start subscap rehab in patients with massive rotator cuff tears Exercises to target subscap. How incorporating the kinetic chain can help your subscap rehab. How to improve subscap recruitment with altered speed of exercise. Plyometrics for subscapularis. Subscapularis rehab in other patients Stiff shoulders - using eccentric subscap exercises to improve range of movement. Whether subscap should be targeted post long head of biceps (LHB) rupture. Improve your rehab of painful and torn shoulders now with this podcast. Get free access to the free video series “Frozen shoulder assessment & treatment” with Jo Gibson at clinicaledge.co/frozenshoulder Improve your assessment and treatment of shoulder pain with the Shoulder: Steps to Success online course with Jo Gibson, now available for enrolment at clinicaledge.co/shouldersuccess Links associated with this episode: Get your access to the free video series “Frozen shoulder assessment & treatment” with Jo Gibson Improve your shoulder assessment & treatment with the Shoulder: Steps to Success online course with Jo Gibson Improve your confidence and clinical reasoning with a free trial Clinical Edge membership Join Jo Gibson live on Facebook & ask your shoulder related questions every Monday Download and subscribe to the podcast on iTunes Download the podcast now using the best podcast app currently in existence - Overcast Listen to the podcast on Spotify Jo Gibson on Twitter Let David know what you liked about this podcast on Twitter Review the podcast on iTunes Infographics by Clinical Edge

Landscape architect Lydia Major recently received a career achievement award from the Minnesota Chapter of the American Society of Landscape Architects. Major is LHB's landscape architecture and planning studio leader, where she oversees a team of mainly women in the firm's Minneapolis and Duluth offices. Her leadership and mentorship of this team — which is unique in the industry — helped Major attain the award, she says. Major began at LHB in 2007, after a former co-worker asked her to join the Minneapolis-based firm. She started her career at Westwood Professional Services after graduating with a master of landscape architecture from the University of Minnesota and a bachelor of arts in English from the University of Wisconsin-Madison. “I sometimes feel like I use my English major more just in daily communication and how we kind of describe [design] to people,” she says. Her work has spanned public, residential and commercial spaces, including the Promenade of Wayzata, the Minnehaha Creek Watershed District Comprehensive Master Plan Document and the Central Riverfront Regional Park Master Plan. In this episode, Major speaks with Reporter Kelly Busche about her career, and how over the past year, she has seen the public's expectations for public spaces like sidewalks, streets and parks, change due to the pandemic and social justice transformation.

La Hora Blanquiazul: OFICIAL. PROGRAMA DEL DÍA 31 de mayo del 2021.Transmitido en vivo por VIVA TV (Movistar 38, Claro 11, Best Cable 91, Señal abierta 11.1) y RADIO OVACION (620 AM). Plantel de LHB con José Antonio y Raúl hablando de:- Entrevista con Juan Sulca, Presidente Conar, sobre la continuidad en el juego.- Balance de la Fase 1.- Lo bueno, malo y por mejorar de cara a la Fase 2.- La Ley del Perro Muerto.- Entrevista a José Carlos Rojas sobre el libro "El Fútbol de Los Íntimos"- Fútbol Femenino Alianza. #LaHoraBlanquiazul #Alianza #Alianzalima #Lima #FútbolPeruano #Perú #Previa #VivaTV #Futbol #Ovacion #Post #partido #Femenino #FutbolFemenino #Bustos #Fase #Libro #Jose #Carlos #Rojas #Perro #Muerto #LeydelPerroMuerto #Hora #BlanquiazulTransmitido EN VIVO todos los lunes a las 8pm por:

La Hora Blanquiazul: OFICIALPROGRAMA DEL DÍA 17 de mayo del 2021.Transmitido en vivo por VIVA TV (Movistar 38, Claro 11, Best Cable 91, Señal abierta 11.1) y RADIO OVACION (620 AM). Plantel de LHB con Raúl y José Antonio, desgranando el Alianza Boys, hablando de si otra vez hay que meter mano al sistema y sobre el estado mental de este Alianza 2021.#LaHoraBlanquiazul #Alianza #Alianzalima #Lima #FútbolPeruano #Perú #Previa #VivaTV #Futbol #Ovacion #Cristal #AlianzaBoys #Bustos► Mira el contenido completo, los programas de 1 hora de los días lunes a las 8:00pm en nuestra página oficial de Facebook: https://www.facebook.com/LaHoraBlanquiazulOficial/► Escucha los programas completos en las plataformas de Podcast: Spotify: https://open.spotify.com/show/6mYPLdz1nHZzXU1W5Ct0FG?si=TCL1WQsfT8OxCdU_WfiZeA iTunes: https://podcasts.apple.com/us/podcast/la-hora-blanquiazul-peru/id1441556748Spreaker: https://www.spreaker.com/show/la-hora-blanquiazul► Síguenos en nuestras redes sociales: Twitter: https://twitter.com/blanquiazulhoraInstagram: https://www.instagram.com/lahorablanquiazulSobre La Hora Blanquiazul. Es un programa semanal de una hora, dirigido y conducido por hinchas de Alianza Lima (el club más popular del Perú), en el que debatimos las incidencias, acontecimientos y noticias de la institución. Los integrantes Manolo, José Antonio y Raúl, discuten cada uno a su manera todo lo que pasa durante la semana y eligen algunos temas de interés.

In this episode, Membership and Operations Associate Allison Ward speaks with Kristen and Melissa from Washington County CDA, Michelle Pribyl from LHB, Inc., and Craig Theis from Colliers Mortgage to discuss the Glen at Valley Creek project that received the prestigious NALHFA Award of Multifamily Excellence in 2020.

La Hora Blanquiazul: OFICIALPROGRAMA DEL DÍA 3 de mayo del 2021.Transmitido en vivo por VIVA TV (Movistar 38, Claro 11, Best Cable 91, Señal abierta 11.1) y RADIO OVACION (620 AM). Plantel de LHB con Manolo, Raúl y José Antonio, haciendo un recuento de la derrota de Alianza con Cristal, las razones, analizar la propuesta ¿conservadora? De Bustos ayer, y ver lo que viene en tema objetivos.#LaHoraBlanquiazul #Alianza #Alianzalima #Lima #FútbolPeruano #Perú #Previa #VivaTV #Futbol #Ovacion #Cristal #AlianzaCristal #Bustos► Mira el contenido completo, los programas de 1 hora de los días lunes a las 8:00pm en nuestra página oficial de Facebook: https://www.facebook.com/LaHoraBlanquiazulOficial/► Escucha los programas completos en las plataformas de Podcast: Spotify: https://open.spotify.com/show/6mYPLdz1nHZzXU1W5Ct0FG?si=TCL1WQsfT8OxCdU_WfiZeA iTunes: https://podcasts.apple.com/us/podcast/la-hora-blanquiazul-peru/id1441556748Spreaker: https://www.spreaker.com/show/la-hora-blanquiazul► Síguenos en nuestras redes sociales: Twitter: https://twitter.com/blanquiazulhoraInstagram: https://www.instagram.com/lahorablanquiazulSobre La Hora Blanquiazul. Es un programa semanal de una hora, dirigido y conducido por hinchas de Alianza Lima (el club más popular del Perú), en el que debatimos las incidencias, acontecimientos y noticias de la institución. Los integrantes Manolo, José Antonio y Raúl, discuten cada uno a su manera todo lo que pasa durante la semana y eligen algunos temas de interés.

In deze aflevering praat ik met LHBTI's over depressie. Die afkorting staat voor lesbische vrouwen, homoseksuele mannen, biseksuelen, transgender- en intersekse personen. Bijna de helft van de Nederlandse LHBTI-volwassenen heeft ooit zelfmoordgedachten gehad, ruim 5x meer dan de gemiddelde bevolking. Is het dan zo slecht gesteld met de acceptatie in Nederland? Wat betekent het om je steeds een ander te voelen? En hoe leidt dat gevoel tot depressies? Ik praat erover met Laura Baams, onderzoeker en docent aan de Rijksuniversiteit Groningen en met Liza Sonneveld, kind- en jeugdpsychiater bij de Care-Express, Opvoedpoli Amsterdam. Daarnaast spreek ik met ervaringsdeskundige Kris van der Veen. Hij groeide op in een klein dorpje in Friesland en werd daar jarenlang gepest. Ze scholden hem al uit voor 'flikker', toen hij nog niet eens wist wat dat betekende. Op een dag, tijdens de gymles, liep het helemaal uit de hand. Hij stond voor zijn gevoel toen voor de keuze: naar de decaan gaan om zijn verhaal te vertellen of een eind aan zijn leven maken. Hij koos het eerste, de school ging aan zijn kant staan en hielp hem weer perspectief te zien voor zijn toekomst. Nu, ruim twintig jaar later, werkt Kris als kwartiermaker LHBTI bij 113-zelfmoordpreventie. Wat is er in die tijd veranderd? Deze aflevering focust zich voornamelijk op de groep: LHB'ers. De volgende aflevering is er meer aandacht voor de groep TIQA+ers. Deze podcast wordt betaald door jullie, mijn luisteraars. Wil jij ook een donatie doen? Ga naar www.gofundme.com/pratenoverdepressie Je vind ons ook op Facebook, Instagram en www.pratenoverdepressie.nl Meer weten of reageren? Mail naar info@pratenoverdepressie.nl

La Hora Blanquiazul: OFICIALPROGRAMA DEL DÍA 15 DE DICIEMBRE 2020 Plantel completo de LHB con Manolo, Raúl y José Antonio, haciendo un recuento de:0:00 Conversamos con Rodrigo Joy Way, quien encabeza una iniciativa denominada Alianza para Todos, con la intención de recaudar ingresos para hacerse cargo de la deuda concursal. 21:30 Nuestra opinión sobre la iniciativa Alianza para Todos.29:00 Analizamos la segunda iniciativa del colectivo OccidentAL.35:00 Sobre si el FB ha o no gestionado el Club y el manejo profesional que se debe tener y la salida de D. Ahmed.48:50 La situación de Carlos Stein y si Alianza jugará Liga 2. Desde lo legal y si en lo deportivo, toda esta incertidumbre puede perjudicar. 71:00 ¿Con qué plantel afrontamos Liga 2?81:30 El caso de Huancayo y lo que se quiso conseguir desde el manejo de prensa.#LaHoraBlanquiazul #Alianza #Alianza Lima #Lima #FútbolPeruano #Perú #DanielAhmed #Ahmed #FondoBlanquiazul #ALianzaBoys #LaHoraBlanquiazul► Mira el contenido completo, los programas de 1 hora de los días lunes a las 8:00pm y La Hora Blanquiazul: En Caliente! (luego de cada partido), en nuestra página oficial de Facebook:https://www.facebook.com/LaHoraBlanquiazulOficial► Escucha los programas completos en las plataformas de Podcast:Spotify: https://open.spotify.com/show/6mYPLdz1nHZzXU1W5Ct0FGiTunes:https://podcasts.apple.com/pe/podcast/la-hora-blanquiazul-peru/id1441556748Spreaker:https://www.spreaker.com/show/la-hora-blanquiazul► Síguenos en nuestras redes sociales:Twitter: https://twitter.com/blanquiazulhoraInstagram: https://www.instagram.com/lahorablanquiazul/Sobre La Hora Blanquiazul.Es un programa semanal de una hora, dirigido y conducido por hinchas de Alianza Lima (el club más popular del Perú), en el que debatimos las incidencias, acontecimientos y noticias de la institución. Los integrantes Manolo, José Antonio y Raúl, discuten cada uno a su manera todo lo que pasa durante la semana y eligen algunos temas de interés.También publicamos un segmento de 15 minutos después de cada partido, en el que desarrollamos lo que pasó en el partido: La Pizarra, el Destacado, el Ni Te Cuento, Te Cambio Tu Cambio, la Portada del día lunes.

LHB del 30 noviembre del 2020.Casi 2 horas en las que intentamos explicar las razones del descenso y cómo cambiar el rumbo de Alianza.

La Hora Blanquiazul: OFICIALPROGRAMA DEL DÍA 23 NOVIEMBRE 2020 Plantel completo de LHB con Manolo, Raúl y José Antonio, haciendo un recuento del momento de Alianza. Los temas de hoy:0:00 Palabras iniciales del panel de LHB, haciendo un análisis integral sobre el actual momento de Alianza, y lo que representa el programa. 12:30 De lo visto en el Alianza Boys que nos deja pensando en negativo, o qué se tiene que modificar para encarar lo que viene.22:30 ¿Cambiando nombres se solucionan algunas cosas? Posiciones encontradas en el programa también sobre las responsabilidades del DT y de los jugadores.36:50 Análisis del fixture y de lo que hay que hacer.41:10 comportamiento del hincha de la Alianza y el enfoque de la prensa deportiva con la situación de Alianza.#LaHoraBlanquiazul #Alianza #Alianza Lima #Lima #FútbolPeruano #Perú #DanielAhmed #Ahmed #FondoBlanquiazul #ALianzaBoys #LaHoraBlanquiazul► Mira el contenido completo, los programas de 1 hora de los días lunes a las 8:00pm y La Hora Blanquiazul: En Caliente! (luego de cada partido), en nuestra página oficial de Facebook:https://www.facebook.com/LaHoraBlanquiazulOficial► Escucha los programas completos en las plataformas de Podcast:Spotify: https://open.spotify.com/show/6mYPLdz1nHZzXU1W5Ct0FGiTunes:https://podcasts.apple.com/pe/podcast/la-hora-blanquiazul-peru/id1441556748Spreaker:https://www.spreaker.com/show/la-hora-blanquiazul► Síguenos en nuestras redes sociales:Twitter: https://twitter.com/blanquiazulhoraInstagram: https://www.instagram.com/lahorablanquiazul/Sobre La Hora Blanquiazul.Es un programa semanal de una hora, dirigido y conducido por hinchas de Alianza Lima (el club más popular del Perú), en el que debatimos las incidencias, acontecimientos y noticias de la institución. Los integrantes Manolo, José Antonio y Raúl, discuten cada uno a su manera todo lo que pasa durante la semana y eligen algunos temas de interés.También publicamos un segmento de 15 minutos después de cada partido, en el que desarrollamos lo que pasó en el partido: La Pizarra, el Destacado, el Ni Te Cuento, las Profecías de LHB, la Portada del día lunes.

La Hora Blanquiazul: OFICIALPROGRAMA DEL DÍA 16 NOVIEMBRE 2020 Esta vez presente el plantel completo de LHB con Manolo, Raúl y José Antonio, haciendo un recuento del momento de Alianza. Los temas de hoy:0:00 Lo que vimos del partido con Cusco FC: ¿Por qué pierde Alianza? ¿Se puede hacer algo con este plantel? 16:00 El Ni Te Cuento del partido24:00 Los cambios de Ahmed.31:25 ¿Cómo Alianza evitará la baja?53:00 Breves reflexiones sobre el formato del torneo#LaHoraBlanquiazul #Alianza #Alianza Lima #Lima #FútbolPeruano #Perú #DanielAhmed #Ahmed #FondoBlanquiazul #ALianzaCusco #CuscoFC #LaHoraBlanquiazul► Mira el contenido completo, los programas de 1 hora de los días lunes a las 8:00pm y La Hora Blanquiazul: En Caliente! (luego de cada partido), en nuestra página oficial de Facebook:https://www.facebook.com/LaHoraBlanqu...► Escucha los programas completos en las plataformas de Podcast:Spotify: https://open.spotify.com/show/6mYPLdz...iTunes:https://podcasts.apple.com/pe/podcast...Spreaker:https://www.spreaker.com/show/la-hora...► Síguenos en nuestras redes sociales:Twitter: https://twitter.com/blanquiazulhoraInstagram: https://www.instagram.com/lahorablanq...Sobre La Hora Blanquiazul.Es un programa semanal de una hora, dirigido y conducido por hinchas de Alianza Lima (el club más popular del Perú), en el que debatimos las incidencias, acontecimientos y noticias de la institución. Los integrantes Manolo, José Antonio y Raúl, discuten cada uno a su manera todo lo que pasa durante la semana y eligen algunos temas de interés.También publicamos un segmento de 15 minutos después de cada partido, en el que desarrollamos lo que pasó en el partido: La Pizarra, el Destacado, el Ni Te Cuento, las Profecías de LHB, la Portada del día lunes.

Link to bioRxiv paper: http://biorxiv.org/cgi/content/short/2020.11.12.378612v1?rss=1 Authors: Velazquez-Hernandez, G., Sotres-Bayon, F. Abstract: Survival depends on the ability to adaptively react or execute actions based on previous aversive salient experiences. Although lateral habenula (LHb) activity has been broadly implicated in the regulation of aversively motivated responses, it is not clear under which conditions this brain structure is necessary to regulate defensive responses to a threat. To address this issue, we combined pharmacological inactivations with behavioral tasks that involve aversive and appetitive events and evaluated defensive responses in rats. We found that LHb pharmacological inactivation did not affect cued threat and extinction learning and memory, anxiety-like or reward-seeking behaviors. Surprisingly, we found that LHb inactivation abolished reactive defensive responses (tone-elicited freezing) only when threat (conditioning) and safety memories (extinction and latent inhibition) compete. Consistently, we found that LHb inactivation impaired active defensive responses (platform-mediated avoidance), thereby biasing choice behavior (between avoiding a threat or approaching food) towards reward-seeking responses. Together, our findings suggest that LHb activity mediates defensive responses only when guided by competing threat and safety memories, consequently revealing a previously uncharacterized role for LHb in experience-dependent emotional conflict. Copy rights belong to original authors. Visit the link for more info

La Hora Blanquiazul: OFICIALPROGRAMA DEL DÍA 9 NOVIEMBRE 2020 Esta vez presente el plantel completo de LHB con Manolo, Raúl y José Antonio, haciendo un recuento del momento de Alianza. Los temas de hoy:0:00 Lo que vimos del partido con Vallejo: los problemas de Alianza, sus laterales, el poco recambio, la no inclusión de Cornejo, entre otras cosas.28:17 Los escenarios de Alianza para lo que resta. Análisis de la pelea por la baja, de lo que viene, y lo que consideramos puede terminar sucediendo.39:15 Las diferencias entre Ahmed y Salas. Respecto del planteamiento, alineación y enfoque de cada partido, analizamos lo que ha cambiado de este Alianza con Daniel Ahmed, en comparación con Mario Salas. #LaHoraBlanquiazul #Alianza #Alianza Lima #Lima #FútbolPeruano #Perú #DanielAhmed #Ahmed #FondoBlanquiazul #ALianzaMelgar #Vallejo #AlianzaVallejo #LaHoraBlanquiazul► Mira el contenido completo, los programas de 1 hora de los días lunes a las 8:00pm y La Hora Blanquiazul: En Caliente! (luego de cada partido), en nuestra página oficial de Facebook:https://www.facebook.com/LaHoraBlanquiazulOficial► Escucha los programas completos en las plataformas de Podcast:Spotify: https://open.spotify.com/show/6mYPLdz1nHZzXU1W5Ct0FGiTunes:https://podcasts.apple.com/pe/podcast/la-hora-blanquiazul-peru/id1441556748Spreaker:https://www.spreaker.com/show/la-hora-blanquiazul► Síguenos en nuestras redes sociales:Twitter: https://twitter.com/blanquiazulhoraInstagram: https://www.instagram.com/lahorablanquiazul/Sobre La Hora Blanquiazul.Es un programa semanal de una hora, dirigido y conducido por hinchas de Alianza Lima (el club más popular del Perú), en el que debatimos las incidencias, acontecimientos y noticias de la institución. Los integrantes Manolo, José Antonio y Raúl, discuten cada uno a su manera todo lo que pasa durante la semana y eligen algunos temas de interés.También publicamos un segmento de 15 minutos después de cada partido, en el que desarrollamos lo que pasó en el partido: La Pizarra, el Destacado, el Ni Te Cuento, las Profecías de LHB, la Portada del día lunes.

La Hora Blanquiazul: OFICIAL Esta vez presente el plantel completo de LHB con Manolo, Raúl y José Antonio, felices por el triunfo ante Melgar pero con mucha cautela y mirando partido a partido. Los temas de hoy:0:00 Saludos de los integrantes3:00 Mario Salas out, ¿acabó el Halloween? Charlamos sobre la salida de Mario Salas y lo que pasó para que no se pueda evitar esta coyuntura.14:50 ¿La decisión Chicho-Ahmed es la mejor para este momento de Alianza? Discutimos sobre lo positivo y lo negativo.19:00 Hablamos sobre el cambio en lo anímico y en lo futbolístico, a propósito de lo visto contra Melgar ¿En qué mejoro Alianza y en donde hay margen de mejora?42:00 Sobre el supuesto reclamo que interpondría Melgar por lo sucedido en Matute.50:45 Sobre el Fondo Blanquiazul y la campaña #CorazónParaAsumir#LaHoraBlanquiazul #Alianza #Alianza Lima #Lima #FútbolPeruano #Perú #ChichoSalas #DanielAhmed #Ahmed #FondoBlanquiazul #ALianzaMelgar #Melgar #LaHoraBlanquiazul► Mira el contenido completo, los programas de 1 hora de los días lunes a las 8:00pm y La Hora Blanquiazul: En Caliente! (luego de cada partido), en nuestra página oficial de Facebook:https://www.facebook.com/LaHoraBlanquiazulOficial► Escucha los programas completos en las plataformas de Podcast:Spotify: https://open.spotify.com/show/6mYPLdz1nHZzXU1W5Ct0FGiTunes:https://podcasts.apple.com/pe/podcast/la-hora-blanquiazul-peru/id1441556748Spreaker:https://www.spreaker.com/show/la-hora-blanquiazul► Síguenos en nuestras redes sociales:Twitter: https://twitter.com/blanquiazulhoraInstagram: https://www.instagram.com/lahorablanquiazul/Sobre La Hora Blanquiazul.Es un programa semanal de una hora, dirigido y conducido por hinchas de Alianza Lima (el club más popular del Perú), en el que debatimos las incidencias, acontecimientos y noticias de la institución. Los integrantes Manolo, José Antonio y Raúl, discuten cada uno a su manera todo lo que pasa durante la semana y eligen algunos temas de interés.También publicamos un segmento de 15 minutos después de cada partido, en el que desarrollamos lo que pasó en el partido: La Pizarra, el Destacado, el Ni Te Cuento, las Profecías de LHB, la Portada del día lunes.

La Hora Blanquiazul: En Caliente! (Post Alianza-Municipal)Programa del día 30 de octubre del 2020 Todo el post partido del Alianza – Municipal, partido disputado el día 30 de octubre, en el que nuestro equipo se dejó voltear 1-2, y ve una situación tremendamente comprometida. Manolo, Raúl y José Antonio comentan y desarrollan los siguientes segmentos:-La Pizarra de LHB-Cómo lo vimos.-El Destacado.-El Ni Te Cuento.-Te cambio tu cambio-La Portada del Partido.-El Latigazo.#LaHoraBlanquiazul #LaHoraBlanquiazulEnCaliente #EnCaliente #Alianza #Alianza Lima #Lima #FútbolPeruano #Perú #AlianzaMunicipal► Mira el contenido completo, los programas de 1 hora de los días lunes a las 8:00pm y La Hora Blanquiazul: En Caliente! (luego de cada partido), en nuestra página oficial de Facebook:https://www.facebook.com/LaHoraBlanquiazulOficial► Escucha los programas completos en las plataformas de Podcast:Spotify: https://open.spotify.com/show/6mYPLdz1nHZzXU1W5Ct0FGiTunes:https://podcasts.apple.com/pe/podcast/la-hora-blanquiazul-peru/id1441556748Spreaker:https://www.spreaker.com/show/la-hora-blanquiazul► Síguenos en nuestras redes sociales:Twitter: https://twitter.com/blanquiazulhoraInstagram: https://www.instagram.com/lahorablanquiazul/Sobre La Hora Blanquiazul:Es un programa semanal de una hora, dirigido y conducido por hinchas de Alianza Lima (el club más popular del Perú), en el que debatimos las incidencias, acontecimientos y noticias de la institución. Los integrantes Manolo, José Antonio y Raúl, discuten cada uno a su manera todo lo que pasa durante la semana y eligen algunos temas de interés.También publicamos un segmento de 15 minutos después de cada partido, en el que desarrollamos lo que pasó en el partido: La Pizarra, el Destacado, el Ni Te Cuento, las Profecías de LHB, la Portada del día lunes.

En 15 minutos analizamos el post del Alianza UTC que terminó 0-2. Secciones:(1) La pizarra(2) Análisis general.(3) El destacado.(4) El ni te cuento.(5) Las profecías de LHB(6) La portada del día siguiente.(7) Arbitraje(8) Transmisión de TV(9) El LatigazoArriba Alianza!!

En 15 minutos analizamos el post del Alianza Melgar que terminó 2-2. Secciones:(1) La pizarra(2) Análisis general.(3) El destacado.(4) El ni te cuento.(5) Las profecías de LHB(6) La portada del día siguiente.(7) Arbitraje(8) Transmisión de TV(9) El LatigazoArriba Alianza!!

Post del Alianza Cusco FC que terminó 0-0. En 15 minutos, recontra caliente, vimos:(1) La pizarra(2) Análisis general.(3) El destacado.(4) El ni te cuento.(5) Las profecías de LHB(6) La portada del día siguiente.(7) Arbitraje(8) Transmisión de TV(9) El Latigazo

En 15 minutos analizamos el post del Alianza Cristal que terminó 1-1. Secciones:(1) La pizarra(2) Análisis general.(3) El destacado.(4) El ni te cuento.(5) Las profecías de LHB(6) La portada del día siguiente.(7) Arbitraje(8) Transmisión de TV(9) El LatigazoArriba Alianza!!

Link to bioRxiv paper: http://biorxiv.org/cgi/content/short/2020.07.31.230201v1?rss=1 Authors: Delcourte, S., Etievant, A., Rovera, R., Mor, D., Cooper, H. M., Le, H. D., Williams, A. E., Panda, S., Azmani, R., Raineteau, O., Coutanson, C., Dkhissi-Benyahya, O., Haddjeri, N. Abstract: Successful antidepressant (AD) treatments are still difficult to achieve. Recently, bright light stimulation (BLS) was shown effective in non-seasonal depression but its mode of action remains elusive. We demonstrate here, using a new mouse model of depression resistant to ADs including ketamine, that chemogenetic activation of lateral habenula (LHb) astroglia prevented the potentiating effect of BLS on the AD response. Additionally, the beneficial action of BLS was associated with upregulation of a specific part of the prefrontal cortex opioid system. These results show that improved behavioral outcome produced by BLS requires habenular astroglia and endogenous opioids as crucial buffer systems. Copy rights belong to original authors. Visit the link for more info

Link to bioRxiv paper: http://biorxiv.org/cgi/content/short/2020.07.15.202614v1?rss=1 Authors: Simmons, S. C., Shepard, R. D., Gouty, S., Langlois, L. D., Cox, B., Nugent, F. S. Abstract: The lateral habenula (LHb) is an epithalamic brain region associated with value-based decision making and stress evasion through its modulation of dopamine (DA)-mediated reward circuitry. Specifically, increased activity of the LHb is associated with drug addiction, schizophrenia and stress-related disorders such as depression, anxiety and posttraumatic stress disorder. Dynorphin (Dyn)/Kappa opioid receptor (KOR) signaling is a mediator of stress response in reward circuitry. Previously, we have shown that maternal deprivation (MD), a severe early life stress, increases LHb intrinsic excitability while blunting the response of LHb neurons to extra hypothalamic corticotropin-releasing factor (CRF) signaling, another stress mediator. CRF pathways also interact with Dyn/KOR signaling. Surprisingly, there has been little study of direct KOR regulation of the LHb despite its distinct role in stress, reward and aversion processing. To test the functional role of Dyn-KOR signaling in the LHb, we utilized ex-vivo electrophysiology combined with pharmacological tools in rat LHb slices. We show that activation of KORs by a KOR agonist (U50,488) exerts differential effects on the excitability of two distinct sub-populations of LHb neurons that differ in their expression of hyperpolarization-activated cation currents (HCN, Ih). Specifically, KOR stimulation increases neuronal excitability in LHb neurons with large Ih currents (Ih+) while decreases neuronal excitability in small/negative Ih (Ih-) neurons. Additionally, we found that an intact fast-synaptic transmission is required for the effects of U50,488 on the excitability of both Ih- and Ih+ LHb neuronal subpopulations. Consistently, KOR activation also altered both glutamatergic and GABAergic synaptic transmission. While stimulation of presynaptic KORs uniformly suppressed glutamate release onto LHb neurons, we found that U50, 488 either increased or decreased GABA release. We also found that MD significantly increased immunolabeled Dyn (the endogenous KOR agonist) labeling in neuronal fibers in LHb while significantly decreased mRNA levels of KORs in LHb tissues compared to those from non-maternally deprived (non-MD) control rats. While total p38 MAPK (a downstream signaling pathway driven by KOR activation) expression was elevated in the LHb of MD rats compared to non-MD controls, we found that application of KOR-specific agonist, U50,488, onto LHb slices was still able to alter phosphorylated p38 MAPK (ph-p38) expression in MD rats similar to non-MD controls. Moreover, we found that the U50,488-mediated increase in LHb neuronal firing observed in non-MD rats was absent following MD. Altogether, this is the first demonstration of the existence of the functional Dyn/KOR signaling in the LHb that can be modulated in response to severe early life stressors such as MD. Copy rights belong to original authors. Visit the link for more info

Link to bioRxiv paper: http://biorxiv.org/cgi/content/short/2020.07.12.197319v1?rss=1 Authors: Tomas E Sachella, Marina R Ihidoype, Christophe Proulx, Jorge H Medina, Pablo Mendez, Joaquin Piriz Abstract: The lateral habenula (LHb) encodes aversive information. However, there is little understanding of how the information provided by the LHb influences learning and memory processes. Fear conditioning (FC) is probably the best understood model of aversive associative learning. Thus, FC constitutes a good behavioral paradigm to analyze LHb function in associative learning. In the present work we studied in rats the effect of interfering with neuronal activity of the LHb on FC using optogenetics and pharmacological tools. We found that exciting or inhibiting the LHb during training, abolishes independent expression of contextual and cued memories, yet memory is normally expressed when the cue is played in the training context. Our results reveal that the formation of independent cued and contextual FC memories requires intact signaling by the LHb assigning to this structure a previously uncharacterized integrative role in brain circuits required for FC learning.Competing Interest StatementThe authors have declared no competing interest. Copy rights belong to original authors. Visit the link for more info

Link to bioRxiv paper: http://biorxiv.org/cgi/content/short/2020.07.09.195610v1?rss=1 Authors: Gian Pietro Serra, Adriane Guillaumin, Jérome Baufreton, François Georges, Åsa Wallén-Mackenzie Abstract: Activation of the subthalamic nucleus (STN) is associated with the stopping of ongoing behavior via the basal ganglia. However, we recently observed that optogenetic STN excitation induced a strong jumping/escaping behavior. We hypothesized that STN activation is aversive. To test this, place preference was assessed. Optogenetic excitation of the STN caused potent place aversion. Causality between STN activation and aversion has not been demonstrated previously. The lateral habenula (LHb) is a critical hub for aversion. Optogenetic stimulation of the STN indeed caused firing of LHb neurons, but with delay, suggesting the involvement of a polysynaptic circuit. To unravel a putative pathway, the ventral pallidum (VP) was investigated. VP receives projections from the STN and in turn projects to the LHb. Optogenetic excitation of STN-VP terminals caused firing of VP neurons and induced aversive behavior. This study identifies the STN as critical hub for aversion, potentially mediated via an STN-VP-LHb pathway.Competing Interest StatementThe authors have declared no competing interest.View Full Text Copy rights belong to original authors. Visit the link for more info

Link to bioRxiv paper: http://biorxiv.org/cgi/content/short/2020.05.15.098319v1?rss=1 Authors: Levinstein, M. R., Coffey, K. R., Marx, R. G., Lesiak, A. J., Neumaier, J. F. Abstract: The lateral habenula (LHb) integrates critical information regarding aversive stimuli that shapes decision making and behavioral responses. The three major LHb outputs innervate dorsal raphe nucleus (DRN), ventral tegmental area (VTA), and the rostromedial tegmental nucleus (RMTg). LHb neurons that project to these targets are segregated and nonoverlapping, and this led us to consider whether they have distinct molecular phenotypes and adaptations to stress exposure. In order to capture a time-locked profile of gene expression after repeated forced swim stress, we used intersectional expression of RiboTag in rat LHb neurons and next-gen RNA sequencing to interrogate the RNAs actively undergoing translation from each of these pathways. The "translatome" in the neurons comprising these pathways was similar at baseline, but diverged after stress, especially in the neurons projecting to the RMTg. Using weighted gene co-expression network analysis, we found one module comprising genes downregulated after stress in the RMTg-projecting LHb neurons; there was an overrepresentation of genes associated with phosphoinositide 3 kinase (PI3K) signaling in this module. Reduced PI3K signaling in RMTg-projecting LHb neurons may be a compensatory adaptation that alters the functional balance of LHb outputs to GABAergic vs. monoaminergic neurons following repeated stress exposure. Copy rights belong to original authors. Visit the link for more info

Link to bioRxiv paper: http://biorxiv.org/cgi/content/short/2020.04.23.056200v1?rss=1 Authors: Nakamura, T., Kurosaki, K., Kanemoto, M., Sasahara, M., Ichijo, H. Abstract: The lateral habenula (LHb) inhibits midbrain monoaminergic neurons, thereby regulating emotion/cognition. Abnormally high activity in the LHb causes behavioral disorders, but how stressful experiences affect neuronal circuits underlying emotion remains poorly understood. Here, we report the effects of chronic stress on the LHb in postnatal day (P)1-9, P10-20, and P36-45 mice in the pre-, early, and late stages of LHb maturation. At P60, only mice exposed during P10-20 exhibited LHb-specific changes: abnormally high-stress reactivity shown by the expression of the immediate-early gene product (Zif268/Egr1) with insufficient number of parvalbumin (PV) neurons containing GABA. Furthermore, these mice showed anxiety/depression-like behaviors in the light-dark box test/ forced swim test. Thus, experiences in early-life are essential for the maturation of neuronal circuits underlying emotion. Early-life stress is thought to have caused anxiety/depression in adulthood by disrupting the maturation of inhibitory PV neurons in the LHb in a period-specific manner. Copy rights belong to original authors. Visit the link for more info

Long head of biceps (LHB) tendinopathy and associated anterior shoulder pain can develop in patients that increase their lifting load eg moving house, overhead activities, activities that involve loaded shoulder extension and in throwing athletes. Patients may also develop long head of biceps tendon pain after a traumatic ACJ injury or SLAP tear. How can you identify and treat LHB tendinopathy? In this podcast with Jo Gibson, you’ll explore: What causes LHB tendinopathy? What mechanisms of injury commonly cause LHB pain, ACJ injury or SLAP tears? Key traumas you need to keep an eye out for that impact LHB Why do patients with ACJ injuries develop LHB pain? Why do patients with SLAP lesions develop LHB pain? What causes LHB reactive tendinopathy? LHB Anatomy & function What activities does LHB help with? Long head of biceps (LHB) anatomy Variance in proximal biceps attachment and how traumatic LHB injuries impact different structures How the LHB is stabilised anatomically in the bicipital groove Does the transverse ligament exist? Patient features that help your diagnosis Which patients are likely to present with LHB pain? Which structures are more likely to be affected with traumatic shoulder injuries in younger vs older patients? Why do young patients with LHB instability develop pain? Subjective history features that help your diagnosis Where do patients with LHB tendinopathy experience pain? Which movements are likely to be painful in LHB tendinopathy patients? Objective testing & diagnosis Which tests or combinations of tests help diagnose LHB pain? Which special tests help your diagnosis? Does palpation have any value in LHB diagnosis? How can you exclude intra-articular pathology with your testing? How can you rule in or rule out rotator cuff pathology? Rotator cuff tears & involvement in LHB How does LHB muscle activity vary in painful vs painfree massive rotator cuff tear patients? How do traumatic rotator cuff tears, particularly subscapularis, impact LHB? If patients have rotator cuff surgery, what details in the operation notes will help you identify if they are at risk of persistent post-op pain and stiffness? Why do subscapularis tears cause LHB pain? Imaging What information does imaging of LHB provide? What imaging can you use if your patient is not progressing? MRI vs MRA vs US for different pain & injuries How to treat LHB What is the best way to treat LHB tendon pain? Are isometrics helpful with LHB, and how do these help? What surgery is used for LHB pain? Additional questions covered How are results after rotator cuff tears impacted by the rotator interval? Links associated with this episode: Download and subscribe to the podcast on iTunes Improve your diagnosis of acute shoulder pain with 3 free videos with Jo Gibson Improve your confidence and clinical reasoning with a free trial Clinical Edge membership Let David know what you liked about this podcast on Twitter Review the podcast on iTunes Like the podcast on Facebook Infographics by Clinical Edge Jo Gibson on Twitter

Seth and Dr. Sap bring you a podcast about Michigan's greatest teams. This episode: certainly the weirdest season ever. Previously: 1901, 1925, 1947, 1964, 1976, 1980, 1999 THE SPONSOR: It is sponsored by HomeSure Lending. If you're buying or refinancing your home, this is the guy to talk to. He'll work on your loan directly and walk you through a process that can get really confusing really fast. I used him. Brian used him. Everyone else who used him is glad they did. [Description, diagrams, some video after the JUMP] -------------------------------------------- 1. MIDCENTURY FOOTBALL (starts at 1:00) From T-Formations to the Korean War and replacing rosters of war heroes with regular ol' sophomores, we look at football as it stood in 1950. Southern football is on the map, and programs are spending insane (for that time) amounts of G.I. Bill money on building projects, especially for their football teams. Recruiting is a thing, but not at Michigan. New facilities are a thing, but not at Michigan. Revamped passing games, War babies, bowl games, the new Coaches Poll, and your fists have to be in on your chest now. 2. THE TEAM THE TEAM THE TEAM (starts at 20:41) BACKS: Bill “ol' One-Play" Putich for his 1 TD pass vs MSU. Not a great QB but smart. Was later moved to HB and was captain in 1951. VERY young--he turned 18 this season, as a junior. Real concern that Army was going to draft him ahead of the game. FB: Don Dufek: Chicago. Dad of Don, Bill, and Joe. Team MVP. They know him at Grand Valley as the AD who turned around the department. 702 yards on 174 carries (4 YPC) and 8 TDs--really he was averaging 5 YPC except that OSU game when he had 14 carries for 9 yards. LHB Chuck Ortmann: Star in ‘49 until he was concussed against Army. Hampered by back injury in ‘50 (could hardly bend over). RHB Leo Koceski: Was more of a slot role, see interview. Backups: HB Don Peterson (5’10/175) charging for Leo's job from the start. LHB: Super sophomores: “mighty mites” Frank Howell (5’8/155) (also 3rd string LHB), Wes Bradford (5’6/155) and Don Oldham (5’8/166). Oldham in for Ortmann but awful fumble.  Also Dan Hill who was compared to the shifty return specialist Gene Derricotte. QB: Ted Topor, blocking type, converted fullback. Bill Billings (Flint), passer, go-to signal caller, good punter. Tom Witherspoon is a defensive specialist. ENDS: Sophs expected to take over. Nervous about this position though there’s hope for Perry. LE Lowell Perry (Ypsilanti, teammate of Hill), Fastest guy on the team, end-around maven, quick passing games, and makes guys miss. Also an excellent safety. RE Harry Allis: Longtime starter, stalwart. LE on defense is Ozzie Clark who's also a good TE, a big quasi-tackle. Big game against Ohio State. Backups: Sophs Fred Pickard, a combo TE, and Merrit Green on defense. LINE: Offensive C Carl Kreager. 6’4/220. Won’t wear gloves. Backup: John Padjen 5’9/180, plays C and G. Started football program at TF South in Chicago, his son Tom was HC for 40 years, and grandson John is now HC. RT Al “Brick” Wahl. Star of the team, captain, All-American. Nephew of Herb Stager. He came to Michigan in 1945 from Chicago but joined the Army that summer and missed the ‘46 and ‘47 seasons so he’s now 23 years old and a vet. LT Tom “Big Gun” Johnson born in Chicago but from Muskegon heights. Washed dishes, competed in football and track. Was Alvin Wistert’s backup but by the time he graduated he was one of the greatest tackles in Michigan history (more on defense than offense). Second African-American to play for the Packers, after former teammate Bob Mann a year prior. LT Bill Ohlenroth: Plays when Johnson needs a breather. Defensive RG Tom Kelsey (a converted end) and later soph Jim Wolter are playing a hybrid DL/LB position. Swing OL John Hess Sprained ankle vs Minneosta. OL Ralph Stribe moved to G this year because T was strong. Defensive LG Dick McWilliams: best MG in the country. 6’3/248 and immovable. LINEBACKERS: C Roger Zatkoff (Hamtramck), super sophomore, Meyer Morton Award, has to replace Dick Kempthorn “a 215-pound converted fullback, is a bone-crusher of the Kempthorn school. FB Tony Momsen, moved over from center, punted, blocked OSU punt and recovered it. Backups: Ted Topor (6’0/215) the blocking fullback, and Dick Strowzewski, who also plays T. 3. INTERVIEW WITH HALFBACK LEO KOCESKI (starts at 38:10) Recruiting in the late '40s, the training table rules, coming up under the Mad Magicians, Fritz Crisler's retirement, the Korean War, Dan Dworsky on the piano. The time he tried kicking. The '49 team and the comedown as the next wave takes over. 4. THE GAMES, THE GAMES, THE GAMES (starts at 1:17:33) Toughest season you can get, with most of the Top 10 on the docket, starting with #9 Michigan State College, "The Football Factory" which had recently been admitted to the Big Ten and immediately placed on some kind of double-secret probation, but beat us . Dartmouth was a good team in '49 but lost a lot of guys, Michigan wins 27-7. #2 Army at Yankee Stadium began the cascade of injuries, beat Michigan 6-27. #16 Wisconsin was a nice homecoming game after the 1-2 start, a 26-13 win. But then a trip to #14 Minnesota ends in a 7-7 tie with Michigan routinely stuck on the doorstep, and an 0-7 loss to #10 Illinois in the snow is a season-killer. Or is it? Indiana goes away 20-7, and Michigan defeats a tough Northwestern team 34-23, the only giant not to lose to them. And then there's the snow bowl.   5. ROSE BOWL (1:51:01) Michigan takes the train to Pasadena and beats #5 Cal. Why yes of course Sap has video of it!   Cal controls play in the first half but has their first huge run called back for an illegal formation, and misses an extra point try. Michigan figures out the trick to a team that cut blocks all the time: step back a yard at the snap then go over them. Michigan also learns the short passing game and takes it down the field to deep in Bear territory. Dufek took over from there. 6. WRAP (2:04:18) It will be some time (1964) before we have another Michigan team to profile, so Sap and I go into the future, where Michigan's facilities and hamstrung recruiting are falling behind the rivals, Woody Hayes is building a dynasty in Columbus that still hasn't really gone away, and we preview a coming fight over the Athletic Department head job that'll set the course of Michigan history for the rest of the century. -------------------------------------------- MUSIC "The Third man Theme"—Anton Karas (you should see this film if you haven't) "Double Crossin' Blues"—Johnny Otis with Little Esther & the Robins "If I knew You Were Coming I'd've Baked a Cake"—Al Hoffman, Bob Merrill, and Clem Watts, performed by Eileen Barton "Let It Snow! Let It Snow! Let It Snow!"—Sammy Cahn and Jule Styne, performed by Frank Sinatra "Yipsee-I-O"—Ray Gilbert, performed by Carmen Miranda with the Andrews Sisters “Across 110th Street” THE USUAL LINKS Helpful iTunes subscribe link General podcast feed link What's with the theme music? Clearly the ball either had the plague or halitosis

http://traffic.libsyn.com/talkinglead/TLP_312_Trains_Planes_and_the_LHB.mp3 Welcome back to episode 312 of the Talking Lead Podcast. Lefty has gathered another YouTube Live panel full of Lead Heads to help narrow down the list of nominations for the pilot of the Lead Head Brigade Hero's Lead Force One plane. Joining Lefty this episode from all around the USA are Lead Heads Amber, Marc, Kennith, Jason, Eric & Michael. A fun episode just for you the listener full of Jackwagons & LHB Heroes. We give away the last ASP USA XT-DF flashlight kit and announce the next Glock webstore gift code giveaway contest. Tune in and get "Leaducated"

75 Chrome Shop & The Long Haul Bandits75 Chrome Shop & The Long Haul Bandits. We sat down with the Long Haul Bandit at the 75 Chrome Shop in Wildwood FL. We talked about everything from bee haulers to bringing back respect in the trucking industry. The bandits are on a mission to better the trucking industry by helping educate those that have not learned about respect. One driver at a time they induct them into the LHB or the Long Haul Bandits Trucker Club. Entrance is not just a signature and you're in. The gate keepers are Sancho and Grump, the Prez and VP. They take the Bandits very serious and they are on guard. If you want to be in the club there are a few things you will have to do and have. The have of course if the "desire". You must really want to be a part of this growing group of truck drivers that want to do things the right way and make the brotherhood of trucking a thing of respect. The second thing you will need to have is a great attitude. You will want to be positive because thats what the industry is in desperate need of. Your Tasks 75 Chrome Shop & The Long Haul Bandits. Your assignment? Just picture "mission impossible" music playing as you're reading this! Your assignment? Help people. Thats right you must record yourself twice a month helping another trucker either back in a door or maybe helping him or her disconnect a trailer but it must be recorded. The second thing you will need to be recorded doing is (Music just got louder Haha) pick up garbage for 15 minutes at a truck stop twice a month. Dent Dent Dent da dent dent dent dent (Music is in dents lol! But seriously this is what you must do to earn your stripes into the club. If your attitude says this sounds dumb then this group is not for you. Think about a new future and is this what you want to be a part of and then move forward. Thank you to the 75 Chrome Shop for having us a there guests. TalKCDL is the Number One Trucking Podcast on planet Earth. This isn't just our claim but yours also.TalkCDL would also like to thank the bandits for inviting us into the group. We look forward to helping this group grow with us. We would also like to invite anyone from the group to come on the show anytime and tell us your story. Events with the Long Haul Bandits Each year the long haul bandits have 2 events. Big Cookouts and a chance for members to come together and actually meet in person. Gear up and get your appetites because when the bandits get together its lots of eating and fellowshipping. Meetings and of course corresponding online is an event its self on a daily basis. One of the first things you will notice is how much everyone is involved on the social media pages. You will notice a very supportive group for one another and that right there is a huge difference from other trucking groups. President Soncho and his VP Sir Grumpster lead the way with daily messages of encouragements. Take the time to really look into this group and Im sure you will find a place where people really do care about you and everyone a part of it. A special thanks to the 75 Chrome Shop. https://www.75chromeshop.comhttp://talkcdl.com/trucker-gun-laws/http://talkcdl.com/s2e27-truckers-face-off-with-protesters/http://talkcdl.com/trucker-fights-the-law-and-wins/https://www.facebook.com/longhaulbandit/

Long Haul Banditz Long Haul Banditz interview. We sat down with the President Sancho Gonzalez and VP Grumpy of the Long Haul Banitz to chat. Who are the Long Haul Banditz? They are a group of men and woman that are trying to reestablish the "Old School" Trucker mentality. The Brotherhood of trucking if you will. This group is on a mission and it doesn't look like they will let anything get In their way! They believe in honor and respect! Grumpy said you got to give respect to get respect. Recently the Banditz showed up at a truck stop as part as their mission. They didn't show up to pass out literature or to protest and make waves. No, instead they showed up armed with trash bags and a great attitude of leading by example. Thats right, including the president of the organization Sancho himself picking up trash. Sancho was filmed picking up "trucker bombs" AKA piss bottles thrown out of semi trucks parked in the lot. This group is trying to change the trucking mentality one mind and one place at a time and its working.https://www.longhaulbandit.com Mission Statement Long Haul Banditz have a mission statement. This statement is like a code or a way of life. They suggest if you want to join the Banditz, to just read the statement. Then read it again and if you agree with the statement you are a Long Haul Bandit. Here is a copy of the mission statement. "Long Haulin’ Banditz (aka LHB) is a brotherhood of truckers created by President Sancho in 2016. The LHB Logo was created by President Sancho to be the symbol of the Old Skool Brotherhood Resurrection. LHB's mission is to re-establish the old school trucker mentality while providing owner operators the ability to expand their businesses. Too many brothers and sisters are trapped in dead-end deals that are highly orchestrated by crooked carriers, brokers, dealerships, and insurance companies. Together we will re-establish the respect and honor that has nearly been lost to the ages. We encourage drivers to help one another, rather than tear each other down. The LHB Brotherhood holds ourselves to the highest standards and will be the drivers that others aspire to be." https://www.longhaulbandit.com/#mission Who Can Be A Bandit The answer is simple. Anyone can be a Long Haul Bandit. If you believe in the mission and you want to live the life, then you are a Long Haul Banditz. You dont have to be Over the road or even a trucker to be a Bandit. If you are willing to stop and give a trucker thats broke down a water or to even just check on him, then you are a bandit. If you practice good and safe driving around semi trucks then you are a bandit. Sancho told us in the interview "If you are going to throw garbage out your window at a truck stop. If you park in the fuel island and stay there for extended periods because your too lazy to park. Just take the Long Haul Banditz shirt off and throw it away. If you stop believing in the mission, just politely burn your shirt and be on your way. Long Haul Banditz TalkCDL Trucking Podcast TalkCDLTalkCDL is a podcast and entertainment for the trucking industry! We encourage you to send in your videos and stories. We are best reached at our facebook page. If you are wishing to be a guest on the show please write to us and tell us what you would like to talk about. Thank you for all the nice emails and messages you send to us. TalkCDL is fueled by our followers and without you we would have quit a coupe years ago. Thank you. Praise the Lord! http://talkcdl.com/fight-over-truckers-dog/

Rick Carter is a Senior Vice President in LHB's Minneapolis office where he utilizes his 30 years of experience to lead the firm's Integrative Design Team, a group of 100 architects, mechanical and electrical engineers, landscape architects, planners and interior designers serving five market sectors. An early adopter of healthy building principles, Rick has led LHB's focus on high-performance design since the early 1990s. He is recognized as an expert in sustainable design and speaks regularly at regional and national conferences on this topic. Rick Carter-Sustainability Minded During Career When Rick was younger he was fascinated by the underground space center.  That center has evolved to the Center for Sustainable Building Research. Sustainability has always been in the forefront of his mind but didn't really come to fruition until he started working.  Rick works extensively on design for efficient resource use and occupant well-being, leading efforts for LHB to be visible experts in regenerative design and research. His projects range from the building to regional scales with the goal of contributing to achieving Minnesota's greenhouse gas emission reduction goals. Rick helped develop the Hennepin County/Minnesota Sustainable Design Guidelines and currently co-manages the Buildings, Benchmarks and Beyond (B3) Project including execution of sustainable guidelines for the State of Minnesota. "We know it's something that we don't know enough about, so we are going to try and learn about it.  We also know that it's okay to go out and tell people we are good at it." – Rick Carter   Proudest Achievements Rick's proudest achievements include his family and two children. Professionally he helps lead a diverse 90 person team; Integrated Design Team. His current projects include the ongoing development of the Regional Indicators Initiative and Local Government Project of Energy Planning (LoGoPEP), large scale efforts created by LHB to provide data and tools for Minnesota local government energy and climate action. “We do amazingly cool projects.” – Rick Carter   Routines and Suggested Books Rick is a list maker and follows through quickly in order to prepare for the next step.  He likes to “clear the stacks” and works hard so he can play hard. Rick enjoys books about the outdoors and climbing. He suggests the following books: Alone at the Top: Climbing Denali in the Dead of Winter by Lonnie Dupre Traction: How Any Startup Can Achieve Explosive Customer Growthby Gabriel Weinberg (Author, Narrator) Justin Mares (Author) LLC Gildan Media (Publisher The Boys in the Boat: Nine Americans and Their Epic Quest for Gold at the 1936 Berlin Olympics by Daniel James Brown   “The key to reading books is when you finish one book you immediately pick up he next book and start reading.” – Rick Carter To hear more about Rick's success at LBH and Green Team, download and listen to the episode!   Learn more about Rick Carter: LinkedIn Website   Connect with Charlie Cichetti and GBES: Charlie on LinkedIn Green Building Educational Services GBES on Twitter Connect on LinkedIn Like on Facebook Google+ GBES Pinterest Pins GBES on Instagram   If you truly enjoyed the show, don't forget to leave a positive rating and review on iTunes.  We have prepared more episodes for the upcoming weeks, so come by again next week! Thank you for tuning in to the Green Building Matters Podcast!   Copyright © 2018 GBES

The long head of biceps tendon and superior labrum can get a hard time in throwing athletes and patients that fall on their arm or shoulder. This can result in long head of biceps tendon pathology or SLAP tears, and cause ongoing shoulder pain. A lot of our shoulder tests are non-specific, and are unable to identify particular structures that are irritated or painful in the shoulder. In the case of the long head of biceps (LHB) tendon and slap tears, there are a few useful tests that in combination with a good history can help you identify when the structures are involved in your patient's shoulder pain. In episode 77 of the Physio Edge podcast, Jo Gibson, Shoulder Specialist Physio and David Pope discuss anterior shoulder pain, LHB pathology and SLAP tears. You will discover: Anatomy of the long head of biceps tendon and superior labrum Why the anatomy is important, and may be different to what you learnt at university around the biceps tendon and bicipital groove The clinical presentation and relevant history of patients with SLAP lesions and LHB tendon pathology Which patients are more likely to get SLAP tears following trauma Special tests that may help you identify LHB pathology and SLAP tears What information imaging gives us When to request imaging for your shoulder pain patients Different groups of patients that develop LHB pathology Rehabilitation of LHB tendon pathology and SLAP tears When to specifically target the LHB tendon, and when to target the surrounding structures for best results Other areas to consider in your rehab beyond the shoulder How the kinetic chain can impact shoulder pain How someone's hop distance can influence their shoulder pain How to start treatment of someone with an irritable LHB tendon Important education components to include in your treatment Time frames - How long do these injuries take to recover? Which patients are suitable for surgical management? Different types of surgery for LHB tendon pathology Which SLAP tear patients should have conservative treatment? How suprascapular nerve involvement can present following traumatic shoulder injury, and how to identify patients with suprascapular nerve compression Links of Interest Free Shoulder assessment videos with Jo Gibson - a series of three evidence-based videos to get you great results with shoulder pain Free sports injuries videos including the AC joint with Jo Gibson Download and subscribe to the podcast on iTunes Jo Gibson on Twitter - @ShoulderGeek1 Let David Pope know what you liked about this podcast on Twitter Review the podcast on iTunes Like the podcast on Facebook Infographics by Clinical Edge Courses - Steps to Success Articles associated with this episode: Hendy et al. 2012. Cross education and immobilisation: mechanisms and implications for injury rehabilitation Kibler et al. 2009. Clinical utility of traditional and new tests in the diagnosis of biceps tendon injuries and superior labrum anterior and posterior lesions in the shoulder McCreesh et al. 2017. Increased supraspinatus tendon thickness following fatigue loading in rotator cuff tendinopathy: potential implications for exercise therapy Parle et al. 2017. Acute rotator cuff tendinopathy: does ice, low load isometric exercise, or a combination of the two produce an analgaesic effect? Saithna et al. 2016. Shoulder Arthroscopy Does Not Adequately Visualize Pathology of the Long Head of Biceps Tendon Schroder et al. 2017. Sham surgery versus labral repair or biceps tenodesis for type II SLAP lesions of the shoulder: a three-armed randomised clinical trial Taylor et al. 2017. The "3-Pack" Examination Is Critical for Comprehensive Evaluation of the Biceps-Labrum Complex and the Bicipital Tunnel: A Prospective Study Exercise videos Thoracic rotation exercise Dynamic rotation exercise Other episodes of interest: PE 043 - Sporting Shoulder with Jo Gibson PE 031 - Unruly scapular assessment and retraining with Ann Cools

p.p1 {margin: 0.0px 0.0px 0.0px 0.0px; font: 12.0px 'Helvetica Neue'; -webkit-text-stroke: #000000} p.p2 {margin: 0.0px 0.0px 0.0px 0.0px; font: 12.0px 'Helvetica Neue'; -webkit-text-stroke: #000000; min-height: 14.0px} span.s1 {font-kerning: none} Bhumi Charitra Mana bhumi eppudu form ayyindi. asalu ela forme ayyindi? asalu enduku form ayyindi? ivanni ee roju mana podcast lo telusukundaam mana bhumi daadaapuga 4.5 billion years ante 450 kotla samvatsarala kritham form ayindi. mana bhumi vayasu, mana bramhandam vayasulo moodo vanthu. ante 1/3rd puttina roju deggira nundi ippatiki mana bhumi lo chalane maarpu vachindi. paiga manchi maarpule anukovali. so mana bhumi good boy/girl anamata. mana bhumi solar nebula lonchi form ayyindi - accretion ane process lo. accretion ante accumulation anamata. pogu cheyatam. oka layer meeda inkoka layer form avvadam laaga. volcanos - agni parvatalu ninchi vachina poga, mana atmosphere - vaatavaranam ga form ayyindi. vachina poga lonchi neeru melliga bhumi meeda varsham laaga padindi. kani mana vaatavaranam lo oxygen ledu aa time lo. Mana bhumi meeda aa time lo manushulu brathike avakasam elag ledu. continuous ga meteors ninchi, vere pedda pedda raallu bhumi meeda padataa undevi. ilanti oka collision lo ne mana chandrudu form ayyadu telusa? melli ga bhumi challarindi, mana bhumi meeda neellu pravahinche avakasam yerpadindi 350 kotla samvatsarala kritam modati jeevi puttindi, ala melli melli ga chetlu manushulu puttaaru. ivalla manam daani gurinchi matlaadukuntunnam. ee process lo modati angam chandrudi formation. aa mundara events ni date cheyadam konchem kastham avtundi. endukante, aa mundaranta mana bhumi oka mandutunna golam laantidi, radioactive isotoping cheyadaniki manaki avakasam ledu. emi evidence dorakadu. kotta techniwues vache daaka, manaki intha varaku ne telusu. chandrudu ela puttaadu anedi chala rojulu mystery ga ne undindi. bhumi chuttu unna debris antha melliga chandrudi laaga form ayyindi annadi modati hypothesis chandrudu vere ekkado putti, melliga bhumi deggara vachi cheraadu anndi inkoka hypothesis. Kaani chandrudu spin, mana spin okate undi - so bhumi ninche putti undaali kaani chandrudi iron core chaala chinnadi and daani relative density kuda takkuva - so inkekkado putti mana deggariki vachi undali vere solar systems lo ilanti collisions chala common, so chandrudu vachi mana deggira putti undali. Kaani chandrudi meeda okka chukka neeru kuda ledu. frozen form lo kuda - So ekkado putti ikkada mana deggira vachi undali so ila rakarakala speculations tho godavalu paddaaru. ee time lo Dr Wilian K Hartman oka hypothesis velikki loki techadu. rendu Mars size planets collide ayyi, oka moon oka earth form ayyi undachu ani. Kaani idi nammadaaniki evaru ready ga leru aa samayam lo. ee theory ela disprove cheyali anna uthsaaham lo tayaru chesina theoretical models entha accurate ga undinayi ante, William Hartman hypothesize chesindi nijame ayyunddachu anedi rujuvu ayyindi. Paiga, moon landing chesi venakki vachina astronauts, moon samples techaaru. chandrudu samples analyze cheyaga, oxygen isotopes evaithe chandrudi meeda unnayo, vaatiki bhumi vaatiki theda ledu. so ila confirm ayyindi chandrudi formation. Paiga chandrudiki bhumi ki jarigina collision entha head on collision ante, bhumi motham chittu chitthu avvalsindi. Kaani adi ade roopam lo undadame kaakunda, aa rendava prapanchaanni lopalaki mingesindi. ee minge process lo, mana bhumi surface antha magma - ante silaa dravam neella laaga paarindi. Ee process taravata, oka boring time anamata. Late Heavy bombardment antaru. anni chinna chinna raalu oka 30 kotla samvatssaralu vachi bhumi ki guddhukuntu undevi. mana bhumi ke kaadu, mana solar system lo unna anni planets/grahala ki Anni grahalu mana suryudi chuttu ippatiki kaana chaala deggariga tirugutu undevi. Planetary resonance ane event lo, jupiter and saturn every revolution appudu, oka jaaga lo stiranga unde vaallu. ee maassive planets yokka impact vacchi lopala unna planets meeda padindi. melli melli ga mercury venus and bhumi bayataki laaga baddayi. ide samayamlo, ee violent change valla solar system chuttu unna comets yeda peda planets ki gudduko saagaaayi. literally prathi graham meeda manam chuse machalu anni LHB period lo ne jarigaayi. Kaani ivi jaragadam chala manchidi ayyindi telusaa? enduku? bhumi meeda sagam kante ekkuva neeru ee comets ae deliver chesayi. avi lekunda ivalla ee lokam lo jeevam anedi saadhyam ayyedi kaademo. ila aadutu paaduthu, mana primordial soup of the ocean lo Jeevam puttindi. Vacche vaaram jeevam gurinchi, adi evolve ayyindi telusukundaam.

p.p1 {margin: 0.0px 0.0px 0.0px 0.0px; font: 12.0px 'Helvetica Neue'; -webkit-text-stroke: #000000} p.p2 {margin: 0.0px 0.0px 0.0px 0.0px; font: 12.0px 'Helvetica Neue'; -webkit-text-stroke: #000000; min-height: 14.0px} span.s1 {font-kerning: none} Bhumi Charitra Mana bhumi eppudu form ayyindi. asalu ela forme ayyindi? asalu enduku form ayyindi? ivanni ee roju mana podcast lo telusukundaam mana bhumi daadaapuga 4.5 billion years ante 450 kotla samvatsarala kritham form ayindi. mana bhumi vayasu, mana bramhandam vayasulo moodo vanthu. ante 1/3rd puttina roju deggira nundi ippatiki mana bhumi lo chalane maarpu vachindi. paiga manchi maarpule anukovali. so mana bhumi good boy/girl anamata. mana bhumi solar nebula lonchi form ayyindi - accretion ane process lo. accretion ante accumulation anamata. pogu cheyatam. oka layer meeda inkoka layer form avvadam laaga. volcanos - agni parvatalu ninchi vachina poga, mana atmosphere - vaatavaranam ga form ayyindi. vachina poga lonchi neeru melliga bhumi meeda varsham laaga padindi. kani mana vaatavaranam lo oxygen ledu aa time lo. Mana bhumi meeda aa time lo manushulu brathike avakasam elag ledu. continuous ga meteors ninchi, vere pedda pedda raallu bhumi meeda padataa undevi. ilanti oka collision lo ne mana chandrudu form ayyadu telusa? melli ga bhumi challarindi, mana bhumi meeda neellu pravahinche avakasam yerpadindi 350 kotla samvatsarala kritam modati jeevi puttindi, ala melli melli ga chetlu manushulu puttaaru. ivalla manam daani gurinchi matlaadukuntunnam. ee process lo modati angam chandrudi formation. aa mundara events ni date cheyadam konchem kastham avtundi. endukante, aa mundaranta mana bhumi oka mandutunna golam laantidi, radioactive isotoping cheyadaniki manaki avakasam ledu. emi evidence dorakadu. kotta techniwues vache daaka, manaki intha varaku ne telusu. chandrudu ela puttaadu anedi chala rojulu mystery ga ne undindi. bhumi chuttu unna debris antha melliga chandrudi laaga form ayyindi annadi modati hypothesis chandrudu vere ekkado putti, melliga bhumi deggara vachi cheraadu anndi inkoka hypothesis. Kaani chandrudu spin, mana spin okate undi - so bhumi ninche putti undaali kaani chandrudi iron core chaala chinnadi and daani relative density kuda takkuva - so inkekkado putti mana deggariki vachi undali vere solar systems lo ilanti collisions chala common, so chandrudu vachi mana deggira putti undali. Kaani chandrudi meeda okka chukka neeru kuda ledu. frozen form lo kuda - So ekkado putti ikkada mana deggira vachi undali so ila rakarakala speculations tho godavalu paddaaru. ee time lo Dr Wilian K Hartman oka hypothesis velikki loki techadu. rendu Mars size planets collide ayyi, oka moon oka earth form ayyi undachu ani. Kaani idi nammadaaniki evaru ready ga leru aa samayam lo. ee theory ela disprove cheyali anna uthsaaham lo tayaru chesina theoretical models entha accurate ga undinayi ante, William Hartman hypothesize chesindi nijame ayyunddachu anedi rujuvu ayyindi. Paiga, moon landing chesi venakki vachina astronauts, moon samples techaaru. chandrudu samples analyze cheyaga, oxygen isotopes evaithe chandrudi meeda unnayo, vaatiki bhumi vaatiki theda ledu. so ila confirm ayyindi chandrudi formation. Paiga chandrudiki bhumi ki jarigina collision entha head on collision ante, bhumi motham chittu chitthu avvalsindi. Kaani adi ade roopam lo undadame kaakunda, aa rendava prapanchaanni lopalaki mingesindi. ee minge process lo, mana bhumi surface antha magma - ante silaa dravam neella laaga paarindi. Ee process taravata, oka boring time anamata. Late Heavy bombardment antaru. anni chinna chinna raalu oka 30 kotla samvatssaralu vachi bhumi ki guddhukuntu undevi. mana bhumi ke kaadu, mana solar system lo unna anni planets/grahala ki Anni grahalu mana suryudi chuttu ippatiki kaana chaala deggariga tirugutu undevi. Planetary resonance ane event lo, jupiter and saturn every revolution appudu, oka jaaga lo stiranga unde vaallu. ee maassive planets yokka impact vacchi lopala unna planets meeda padindi. melli melli ga mercury venus and bhumi bayataki laaga baddayi. ide samayamlo, ee violent change valla solar system chuttu unna comets yeda peda planets ki gudduko saagaaayi. literally prathi graham meeda manam chuse machalu anni LHB period lo ne jarigaayi. Kaani ivi jaragadam chala manchidi ayyindi telusaa? enduku? bhumi meeda sagam kante ekkuva neeru ee comets ae deliver chesayi. avi lekunda ivalla ee lokam lo jeevam anedi saadhyam ayyedi kaademo. ila aadutu paaduthu, mana primordial soup of the ocean lo Jeevam puttindi. Vacche vaaram jeevam gurinchi, adi evolve ayyindi telusukundaam.

Backround: The treatment of rotator cuff tears is still challenging. Tendon tissue engineering (TTE) might be an alternative in future. Tenocytes seem to be the most suitable cell type as they are easy to obtain and no differentiation in vitro is necessary. The aim of this study was to examine, if the long head of the biceps tendon (LHB) can deliver viable tenocytes for TTE. In this context, different isolation methods, such as enzymatic digestion (ED) and cell migration (CM), are investigated on differences in gene expression and cell morphology. Methods: Samples of the LHB were obtained from patients, who underwent surgery for primary shoulder arthroplasty. Using ED as isolation method, 0.2% collagenase I solution was used. Using CM as isolation method, small pieces of minced tendon were put into petri-dishes. After cell cultivation, RT-PCR was performed for collagen type I, collagen type III, decorin, tenascin-C, fibronectin, Scleraxis, tenomodulin, osteopontin and agreccan. Results: The total number of isolated cells, in relation to 1 g of native tissue, was 14 times higher using ED. The time interval for cell isolation was about 17 hours using ED and approximately 50 days using CM. Cell morphology in vitro was similar for both isolation techniques. Higher expression of collagen type I could be observed in tenocyte-like cell cultures (TLCC) using ED as isolation method (p

HGT and hybridization, Do physical laws imply a lawgiver, Dinosaur cave drawings evidence for young earth, LHB and model predictions