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Last time we spoke about the second Okinawa Offensive. In the brutal Second Okinawa Counteroffensive, American forces confronted staunch Japanese defenses, with Captain Ryan leading a valiant charge for territory. Despite fierce resistance and heavy casualties, his troops managed to seize crucial ground, enduring intense hand-to-hand combat atop Ryan Ridge. The battle raged on, with American forces fighting through exhaustion and dwindling supplies, while the Japanese, though determined, faced declining morale as they lost ground. The relentless struggle exemplified extraordinary sacrifice on both sides, but it foreshadowed a turning point in the Pacific campaign. As American advances continued, the tide shifted, marking the beginning of the end for Japanese dominance in the region, ultimately paving the way for Allied victory. This episode is the Battle of the Malacca Strait Welcome to the Pacific War Podcast Week by Week, I am your dutiful host Craig Watson. But, before we start I want to also remind you this podcast is only made possible through the efforts of Kings and Generals over at Youtube. Perhaps you want to learn more about world war two? Kings and Generals have an assortment of episodes on world war two and much more  so go give them a look over on Youtube. So please subscribe to Kings and Generals over at Youtube and to continue helping us produce this content please check out www.patreon.com/kingsandgenerals. If you are still hungry for some more history related content, over on my channel, the Pacific War Channel you can find a few videos all the way from the Opium Wars of the 1800's until the end of the Pacific War in 1945.  After the failure of their second offensive, the Japanese turned all their energies toward waging a prolonged battle of attrition. Their losses did not impair immediately their defensive capacities; thus the 24th Corps found no weak point in the Shuri defenses resulting from the ill-starred offensive. By throwing fresh troops into the attack of 4 May Ushijima had been able to maintain his strength all along the line. Nor was there any breakdown in his command and staff operation. Front-line units were reorganized without seeming loss of effectiveness; available reinforcements were carefully allotted to existing regiments; local counterattacks were timed for maximum effect. General Ushijima's chief task now was to keep sufficient combat troops at the front to man his Shuri defenses. It was apparent by 7 May that the strength of the remaining regular infantry was not great enough for this task. Consequently, Ushijima converted service units into infantry combat groups. By mixing service troops with the "regulars," he exacted from them their maximum combat effectiveness. "One man in ten will continue with his rear-echelon duties. The remaining nine men will devote themselves to antitank combat training," one order stated. The reorganization of the 32d Regiment, 24th Division, was typical of the resourcefulness of the Japanese. The regimental headquarters received 5 men from the 24th Transport Regiment. The 1st Battalion kept its own surviving members and was allotted all the survivors of the 2d Battalion, 20 men from the 7th Shipping Depot, 90 from the 24th Transport Regiment, and y from the 26th Sea Raiding Squadron. The 2d Battalion was totally reconstituted from the 29th Independent Infantry Battalion and other units. The 3d Battalion was reorganized in a manner similar to that used with the 1st. It was by this process of piecing units together that the 32d Army was able to stay intact long after the original combat units had been virtually destroyed, a capability which at the time American intelligence officers found "baffling." After his offensive failed, the enemy formed a line in which the relative position of the major units was to remain roughly the same until the end of the battle. On the east the 24th Division, reinforced by two independent battalions, held the line as far as Shuri, with its 89th Regiment on the east, its 22d in the center, and its 32d on the west. The remnants of the battered 62d Division were stretched from a point north of Shuri almost to the west coast, holding about one-third of the line. Along the Asa River estuary was a battalion of the 44th Independent Mixed Brigade. The Japanese husbanded their remaining heavy weapons, especially their artillery, as carefully as they meted out their manpower. On 6 May the Japanese 5th Artillery Command directed its units to "revert to the [defensive] situation which held prior to the attack situation of 3 May." Once again the protection of individual pieces was a cardinal feature of enemy operations. Artillery units were ordered to "use ammunition with the utmost economy" and to "wait and fire for effect against vital targets." Along the west coast, preliminary plans were underway for the deployment of General Shepherd's 6th Marine Division to the front lines, while General Del Valle's 1st Marine Division continued its assault on the Dakeshi-Awacha hill complex. Colonel Snedeker's 7th Marines secured the coastal flank after capturing the north bank of the Asa River. Meanwhile, Colonel Arthur Mason's 1st Marines focused their efforts on the western approaches to the Dakeshi hill defenses, but they were ultimately repulsed by the tenacious Japanese defenders around Hill 60. In the Awacha Pocket, Colonel Griebel's 5th Marines faced fierce opposition, resulting in only modest territorial gains. To the east, after successfully fending off multiple strong enemy counterattacks, General Bruce's 77th Division advanced 800 yards south toward Hill 187, establishing control over the southern slope of the Maeda Escarpment. Finally, operations in General Arnold's 7th Division area were confined to robust patrols aimed at securing the approaches to Conical Hill and eliminating the remaining fragments of the failed Japanese counteroffensive. Convinced that the Japanese had nearly exhausted their fresh reserves, General Buckner began planning a comprehensive assault on the Shuri defenses with his two corps. On May 7, General Geiger was assigned to command the 1st Marine Division within the 24th Corps front and oversee the southern movement of the 6th Marine Division, with General Buckner taking direct tactical control of the two-corps assault. Heavy rains on the morning of 7 May delayed the projected IIIAC advance until tanks were able to negotiate the muddy terrain. In the 1st Marines' zone, the new regimental commander, Colonel Arthur T. Mason, ordered 3/1 to support the attack of the 2d Battalion on Hill 60 with all available weapons (four battalions of artillery, a fire support ship, and 81-mm. and 60-mm. mortars) by firing into the enemy reverse slope defenses. All morning long the regiment's mortars concentrated on the enemy position, and at 1400 when tanks finally reached the front lines the battalion attacked with Company E in assault. Artillery fire covered the foot of the objective while mortars and assault guns blanketed the crest and reverse slopes. The company swept to the top of Hill 60 by 1422 in a vivid demonstration of "the effect of properly massed, supporting fires in front of assault troops." Once the company entered the impact zone, however, and supporting fires were shifted to other targets the enemy defenders emerged from their caves and engaged the Marines in hand grenade duels. The fighting was at such close range that it was impossible to keep enough grenades on the line, and the marines used rifle butts against Japanese who tried to storm their position. Gradually the volume of Japanese fire of all types "grew noticeably stronger and progressively more intense so that it was evident that the enemy was receiving large reinforcements." The troops lost their hold at one point, then fought their way to the top again, yet the continuing Japanese fire from the reverse slope of Nan Hill was the decisive factor. The threat of a strong counterattack measured against the dwindling strength of Company E forced Lieutenant Colonel Magee to adjudge the company's advanced position untenable and to order a withdrawal to the previous night's lines. To the west, the 5th Marines steadily advanced approximately 400 yards in the Awacha Pocket, while the 77th Division gained up to 500 yards of enemy territory despite increasingly fierce resistance. By the end of the day, Colonel Coolidge's 305th Regiment had relieved the weary 307th. On the east coast, Colonel Green's 184th Regiment resumed its southward push, quickly capturing Gaja Ridge and William Hill, but faced greater opposition as they approached the western flanks of Conical Hill. Meanwhile, Colonel Pachler's 17th Regiment continued its assault toward Zebra Hill but could only secure How Hill and make incremental gains on Kochi Ridge, depleting their strength. The following day, as General Bradley's replenished 96th Division prepared to relieve the 7th, the 184th Regiment managed to occupy the forward slope of Easy Hill near Kibara without armored support. Throughout the rest of the 10th Army front, relentless cold rain effectively canceled planned offensive operations, leading the 1st Marines to focus on dismantling enemy positions on Nan Hill. Colonel Schneider's 22nd Marines took over from the 7th Marines along the Asa River just as news of the victory in Europe reached the infantry units, prompting a somewhat indifferent reaction from the rain-soaked soldiers preoccupied with the ongoing fighting in Okinawa. Exactly at 1200 every available artillery piece and naval gun fired three volleys at vital enemy targets to apprise the Japanese of the defeat of their Axis partner. On May 9, Japanese kamikaze pilots launched a series of scattered attacks, damaging the carrier Formidable and two destroyers. In preparation for Buckner's general offensive, the 22nd Marines patrolled their front to identify suitable crossing sites over the Asa River. Meanwhile, with Nan Hill fully cleared, Mason's 2nd Battalion renewed its assault on Hill 60, while the 1st Battalion advanced into the high ground to the east, successfully capturing their objective this time. Reinforced by elements of the 7th Marines, the 5th Marines also launched another attack on the Awacha Pocket but continued to encounter fierce resistance. In response, Griebel was tasked with reducing the Awacha defenses using two battalions, while Snedeker's reinforced 7th Marines pressed the offensive southward. To the east, General Bruce focused his efforts on the 305th Regiment's sector, resulting in the 3rd Battalion securing a foothold on Hill 187. The 17th Regiment, which had fought tenaciously to capture Kochi Ridge and the high ground west of Conical Hill, was relieved by Colonel Dill's 382nd Regiment. Concurrently, Colonel May's 383rd Regiment moved into forward assembly areas behind the 184th and on May 10, took over the positions north of Conical Hill. Both fresh regiments of the 96th Division were then able to destroy enemy strongpoints that had impeded the progress of the weary 7th Division and capture key hills that protected the approaches to Conical. On the west coast, after stealthily constructing a footbridge across the Asa during the night, three companies of the 22nd Marines successfully crossed the river. However, two Japanese "human demolition charges" emerged from hiding and rushed the south end of the footbridge, destroying it. Despite the challenges, the attack south toward the town of Asa continued, successfully establishing a bridgehead that stretched 1,400 yards long and 350 yards deep by the end of the day. To the east, the 1st Marines launched an assault on the western end of Dakeshi but were pushed back by intense enfilading fire from the ridge. Similarly, although the 7th Marines initially advanced rapidly against scattered opposition, they were ultimately forced to withdraw under heavy Japanese fire. Behind them, after fending off two fierce night counterattacks, the 5th Marines failed to isolate the Awacha Pocket but made significant strides, penetrating deep into the heart of the Awacha defenses. Meanwhile, the 305th Regiment captured additional high ground leading toward the crucial road junction north of Shuri, where the reorganized and reinforced 32nd Regiment had established its primary defenses. The remnants of the 62nd Division were gradually being withdrawn toward Shuri, with General Suzuki's fresh 44th Independent Mixed Brigade taking over the western sector. On May 11, General Buckner initiated his general offensive against Shuri, planning to envelop the town from both the west and east. However, this offensive was preceded by Admiral Ugaki's sixth mass Kikisui strike, during which 150 kamikazes launched successful attacks on American shipping. That morning, the 721st Kokutai's Sub-Lieutenant Yasunori Seizo led six kamikazes out of Kanoya. By 10:02, Admiral Mitscher was informed of possible bogeys infiltrating the returning TF 58 strike to reach the US carriers. Two minutes later came an overhead Corsair's sudden frantic warning: “Alert! Alert! Two planes diving on the Bunker Hill!” Almost immediately, Yasunori's Zero dove out of low overcast toward Bunker Hill and released its payload. The 550lb bomb pierced the flight deck, exited the side of the hull, and exploded above water. Simultaneously, Yasunori's Zero caromed into the center of Bunker Hill's flight deck, its gas tank exploding among 34 manned, armed, and fully fueled US fighters, before careening blazing over the side. One minute later, Yasunori's wingman Ensign Ogawa Kiyoshi roared past Bunker Hill, climbed steeply into a roll, and then dove straight at the carrier. Ogawa released his 550lb bomb, which scored amidships and exploded in the gallery deck, slaughtering much of Mitscher's staff. Simultaneously, Ogawa deliberately slammed his Zero into Bunker Hill's island just 100ft from Mitscher. Mitscher's operations officer, Commander Jimmy Flatley, had just left the gallery deck when Ogawa's bomb struck, searing his back. Mitscher had observed the entire attack in silence, and just then emerged from the bridge to gaze at the blazing flight deck. The Flag Plot was choked with billowing smoke and Mitscher's chief-of-staff, a gasping, wheezing Commodore Arleigh Burke, ordered it evacuated. A third Zero then dove on Bunker Hill, but anti-aircraft fire sent it blazing into the sea close aboard. Aboard Bunker Hill, a cascade of gasoline explosions erupted from burning planes aft, while tracers sprayed haphazardly from detonating machine gun ammunition. Speed fell to 10kts and as the crew began intensive firefighting efforts, a slight list developed. Cruiser Wilkes-Barre and three destroyers came alongside to fight fires and rescue 300 men forced overboard, yet most of Bunker Hill's fighter pilots had been asphyxiated in their ready room. By 11:30, however, damage was largely stabilized. Nevertheless, Bunker Hill had lost 393 men killed and 264 wounded. Although horribly outnumbered, the Americans' Corsair CAP shot down 50 attackers before the Japanese got through at 0800hrs. Over the next 90 minutes the two violently maneuvering destroyers would claim a combined 42 kills before Evans was disabled by four kamikaze hits. Minutes later Hugh W. Hadley was knocked out by her third kamikaze hit. With his ship dead in the water and blazing uncontrollably, Hugh W. Hadley's Commander Mullaney ordered all available colors hoisted: “If this ship is going down, she's going down with all flags flying.” Escorting the destroyers were three LCS(L)s and one LSM(R), who themselves combined to splash 14 Japanese planes before the action mercifully ended. All six ships survived, but the destroyers were towed to Kerama Retto, having suffered a combined 60 killed and 94 wounded. East of Okinawa, a G4M Betty bomber and four Ki-43 Oscars attacked RPS-5 at 0800hrs. One plane crashed destroyer-minelayer Harry F. Bauer (DM-26)'s stern, the kamikaze miraculously “plowing through the rack of depth charges and shoving them into the sea with none of them exploding.” Escorting LCS(L)-88 splashed two Oscars, the second scoring a posthumous 220lb bomb hit on her which killed nine and wounded seven. Back on the west coast, supported by tanks and artillery, the 22nd Marines advanced toward Amike. Their 3rd Battalion established control of the high ground overlooking Naha after an 800-yard advance, while the 1st Battalion gained the coral ridge in front after a series of costly assaults. The 2nd Battalion further extended the line to connect with the 1st Marine Division. Del Valle's advance was spearheaded by Mason's 2nd Battalion, which successfully secured a foothold on the high ground west of Wana despite a heavy artillery bombardment. In constructing the Wana position the Japanese had "taken advantage of every feature of a terrain so difficult it could not have been better designed if the enemy himself had the power to do so." With this natural advantage, the enemy had so organized the area that in order to crack the main line of resistance it was necessary for the 1st Marine Division to wheel towards Shuri and attack directly into the heart of the city's powerful defenses. Any attempt to drive past Shuri and continue the attack to the south would mean unacceptable losses inflicted by artillery, mortar, automatic-weapons, and rifle fire coming from the heights that commanded the division's flank and rear areas. The southernmost branch of the Asa Kawa wandered across the gently rising floor of Wana Draw and through the northern part of Shuri. The low rolling ground bordering the insignificant stream was completely exposed to enemy fire from positions along the reverse slope of Wana Ridge and the military crest of the ridge to the south. At its mouth Wana Draw was approximately 400 yards wide, but it narrowed drastically as it approached the city and the ridge walls closed on the stream bed. Guarding the western end of the draw was Hill 55, rugged terminus of the southern ridge line. The hill bristled with enemy guns whose fields of fire included the whole of the open ground leading to the draw. Defending the Wana position was the 64th Brigade of the 62d Division with remnants of the 15th, 23d, and 273d Independent Infantry Battalions, the 14th Independent Machine Gun Battalion, and the 81st Field Antiaircraft Artillery Battalion under its command. The 7th Marines advanced approximately 800 yards, establishing a firm hold on Dakeshi Ridge, while the 5th Marines eliminated the last organized resistance in the Awacha Pocket. In the center of the front, Bruce's two regiments needed to coordinate more closely with neighboring divisions than with one another. As a result, the 305th Regiment advanced up to 500 yards against fierce resistance, while Colonel Smith's 306th Regiment struggled to make headway against the formidable defenses of Chocolate Drop Hill and Wart Hill. To the east, after repelling a series of night counterattacks, the 382nd Regiment consolidated its positions on Zebra Hill and continued probing toward the Dick Hills area and the ridges northwest of Kuhazu. The 383rd Regiment quickly secured Easy and Fox Hills, subsequently capturing the summit of Charlie Hill. However, over the next two days, efforts by the 1st Battalion to dislodge the defenders from the top would be thwarted by withering fire from King Hill, while the 2nd Battalion cleared Gaja Ridge and the twin villages of Tobaru and Amaru. On May 12, Dill's 3rd Battalion executed a successful assault, capturing Baker Hill, although the 1st Battalion's attack on Dick Baker was repelled by the defenders. To the west, the 306th Regiment only provided support for the advance of the 305th, which faced difficult terrain in the broken ground west of Route 5, managing to gain about 500 yards. Meanwhile, the 7th Marines solidified their hold on Dakeshi Ridge against sporadic opposition, but the 1st Marines found themselves pinned down while trying to improve their positions west of Wana. The vulnerability of the 6th Marine Division to direct fire from the western slopes of the Shuri massif resulted in significant losses for Schneider's 2nd Battalion as it fought to seize the high ground overlooking Naha, ultimately being repelled from Sugar Loaf Hill. Meanwhile, the 1st Battalion advanced steadily in the center, capturing the high ground north of Asato, while the 3rd Battalion secured commanding positions and conducted patrols through the suburbs of Naha. At sea, scattered kamikaze attacks damaged Admiral Spruance's flagship, the battleship New Mexico, and inflicted further damage on two additional destroyers the following day. In retaliation, Mitscher directed Task Force 58 to strike Kyushu once again. Back on Okinawa, as Schneider's 3rd Battalion reconnoitered the northern suburbs of Naha, the 2nd Battalion launched another unsuccessful attack on Sugar Loaf Hill. In light of this resistance and the heavy casualties suffered by the 22nd Marines, Shepherd ordered Colonel Whaling's 29th Marines to reinforce the effort, but they could only position themselves northwest of Makabe. To the east, while the 1st Marines faced heavy losses and were repelled at the mouth of Wana Draw, the 7th Marines finally secured Dakeshi Ridge. In the center, the 305th Regiment continued its determined advance into the extremely rugged terrain north and northeast of Shuri, whereas the 306th Regiment once again failed to capture Chocolate Drop Hill and Wart Hill. Coordinated with this, the 382nd Regiment attacked the Dick Hills, successfully securing Dick Baker and Dick Able against light opposition, but ultimately being pushed back from the latter. Further east, May's 2nd Battalion launched a frontal assault on Conical Hill, successfully reaching the northeast crest of the ridge, where it repelled several heavy Japanese counterattacks. Back at sea, Task Force 58 launched another strike on Kyushu during the early hours of May 14. In response, the Japanese dispatched 28 kamikazes alongside 40 escorts, inflicting heavy damage on Mitscher's new flagship, the carrier Enterprise, in what would become known as the last action of the Gray Ghost.  At 05:25, some 28 Zeros, armed with 1100lb bombs, sortied from Kanoya towards Mitscher's carriers cruising 130nm southeast of Kyushu. 40 fighters escorted them. Around 06:45 Enterprise detected 4 incoming bogies. 3 were shot down over TF 58, but the fourth, flown by Sub-Lieutenant Tomiyasu Shunsuke, continued closing. Using clouds for cover, Tomiyasu approached Enterprise from astern. Already struck by flak, at 06:57 Tomiyasu's blazing Zero suddenly appeared 200ft above Enterprise, which erupted with anti-aircraft fire. Although seeming to have overflown his target, Tomiyasu suddenly snap-rolled his burning Zero onto its back and dove almost vertically into Enterprise's flight deck. Observing from Enterprise's exposed bridge wing, Flatley rushed back inside and shouted to take cover just as Tomiyasu's kamikaze hit. The thunderous explosion blew Enterprise's forward elevator 400ft in the air, rattled the carrier's bridge, and flung shrapnel against her island. As Flatley emerged from cover he observed an unsmiling Mitscher, arms crossed, standing amid the smoking wreckage. “Jimmy,” Mitscher growled, “tell my Task Group commanders that if the Japs keep this up they're going to grow hair on my head yet.” Enterprise remained on station, but her flight deck was out of action. TF 58 splashed 3 more planes before Japanese attacks ended at 08:00. That evening TF 58 retired from Kyushu. The following morning, May 15, Mitscher transferred to carrier Randolph, his third flagship in 5 days. Enterprise would detach for repairs in the United States on May 16, having lost 14 dead and 68 wounded. Her war too was over. Honestly for those of you who might not know, the USS Enterprise is the most decorated ship of all time, an absolutely insane history. She was so impressive, my patreons voted for me to do an exclusive episode on her and it took two full episodes to do. If you are interested in the history of the USS Enterprise, please check out my exclusive podcast. At Okinawa, as positions on Conical Hill were being consolidated, May's 1st Battalion renewed its attack on Charlie Hill, successfully securing a foothold at its northern end, which was later extended down the southern slope. Simultaneously, Company L launched an assault on King Hill, managing to capture the entire crest. To the west, Dill's 1st Battalion attacked and captured Dick Able and Dick Right, although they had to relinquish Dick Right after a vigorous Japanese counterattack. The 3rd Battalion also advanced toward Dick Right, establishing a tenuous hold on the position. Further west, the 306th Regiment committed its last remaining strength, a composite battalion, to advance beyond Wart Hill, but it was quickly cut down by overwhelming flanking fire. Similarly, the battered 305th Regiment made little progress in the rugged terrain. Meanwhile, the 7th Marines advanced to within 100 yards of the ridge crest north of Wana, where they were ultimately pinned down by heavy fire. Concurrently, the depleted 1st Marines launched an assault that captured the western tip of Wana Ridge, aided by tanks and artillery, though a fierce night counterattack forced them to withdraw before being relieved by the fresh 5th Marines. Along the coast, the 22nd Marines successfully pushed toward the north bank of the Asato River, but the main action was poised to occur at Sugar Loaf Hill. Though Schneider's 2nd Battalion successfully seized the forward slopes of the protective hills north of Sugar Loaf, including Queen Hill, they faced intense enemy fire whenever they attempted to maneuver around or over these hills to launch an attack on Sugar Loaf itself. Nevertheless, the Marines pressed on, and by nightfall, a group of about 40 men under Major Henry Courtney managed to storm the hill, throwing grenades ahead of them and subsequently digging in at the summit to withstand a night of heavy mortar fire and constant counterattacks. This attack was further supported by the 29th Marines, which, after overcoming initial hardships, secured the forward slopes of the hill northeast of Sugar Loaf. During the early hours of May 15, the embattled group atop Sugar Loaf gratefully welcomed the arrival of reinforcements, though it was not before Major Courtney heroically fell while leading a grenade assault against the defenders on the reverse slope. Despite the reinforcements, enemy pressure on Sugar Loaf intensified, ultimately forcing the battered Marines off the hill. This triggered a fierce Japanese counterattack across a 900-yard front, compelling Schneider's 2nd Battalion to relinquish the ground immediately north of Sugar Loaf. Fearing a breakthrough, elements of his 1st Battalion seized the hill northwest of Sugar Loaf to help blunt the force of the enemy counterattacks, while the 3rd Battalion relieved the exhausted 2nd across the line. Additionally, the 29th Marines not only played a significant role in repulsing the enemy counterattack but also effectively strengthened its hold on the high ground north of Half Moon Hill.  To the east, while the 7th Marines reorganized and cleared out Dakeshi, the 5th Marines launched their first tank-infantry assault against Wana Draw. At 0630 on 15 May the 5th Marines completed the relief of the 1st, and Colonel Griebel assumed command of the zone of action west of Wana. The 2d Battalion was in assault with the 3d in close support and the 1st in reserve. On the recommendation of the regimental and battalion commanders of both the 1st and 5th Marines, the division decided to subject the high ground on both sides of Wana Draw to a thorough processing by tanks and self-propelled 105mm howitzers before 2/5 attempted to advance across the open ground at the mouth of the draw. With Company F of 2/5 providing fire teams for protection against suicide attackers, nine tanks from Company B, 1st Tank Battalion spent the morning working on the positions at the mouth of the draw. The tanks drew heavy small-arms, mortar, artillery, and AT fire, and accompanying infantry was dispersed to reduce casualties. Because of the open area of operation, the fire teams were still able to cover the tanks at relatively long-ranges. Both sides of the draw were honeycombed with caves and the tanks received intense and accurate fire from every sector at their front. During the morning one 47mm AT gun scored five hits on the attacking armor before NGF silenced it. About noon the tanks withdrew to allow an air strike to be placed in the draw and then return to the attack in reinforced strength. Naval gunfire again silenced a 47mm gun that took the tanks under fire, this time before any damage was done. With the approach of darkness the tanks pulled out of the draw pursued by a fury of enemy fire. The 5th Marines, convinced "that the position would have to be thoroughly pounded before it could be taken," scheduled another day of tank-infantry processing for Wana Draw before making its assault. In the center, the battered 305th Regiment continued its relentless advance through the irregular terrain west of the main Ginowan-Shuri highway. Simultaneously, Colonel Hamilton's 307th Regiment finally relieved the exhausted 306th and launched simultaneous attacks on Flattop and Chocolate Drop Hill. The 3rd Battalion slowly maneuvered toward the northern base of the Drop and the north slopes of Flattop, while the 2nd Battalion advanced toward Ishimmi Ridge through the open highway valley. Concurrently, the 382nd Regiment supported the assault on Flattop with its own attack against Dick Hill, successfully capturing its crest but failing to cross the skyline. Meanwhile, the 383rd Regiment struggled to make progress against intense enemy fire from the hill complex southwest of Conical's peak, although some elements managed to advance up the northwest spur from King Hill amid thick mortar fire.  Now, it's time to shift our focus from Okinawa to the sea, where we will cover the last destroyer actions of the Second World War. At the beginning of February, with the Southwest Area Fleet staff isolated in the Philippines, Vice-Admiral Fukudome Shigeru formed the 10th Area Fleet to defend the shores of Indonesia and Indochina. The 10th Area Fleet was comprised of the remnants of the 2nd Striking Force. This consisted of the two converted battleship/aircraft carriers Ise and Hyuga, forming the carrier squadron, and the two heavy cruisers Ashigara and Haguro, forming the 5th Cruiser Division. Two more heavy cruisers, Takao and Myoko, were at Singapore where both had reached sanctuary after being badly damaged in the Battle of Leyte Gulf. Myoko had made one attempt to escape back to Japan in December 1944, but had been torpedoed by the US submarine Bergol on the 13th, and had then returned to Singapore. The cruiser Oyodo joined the fleet from February 5 to 20 and a fourth cruiser, Isuzu, joined on March 25 but lasted barely a fortnight before being sunk, on April 7, in a coordinated attack by the US submarines Charr, Gabilan and Besugo, with peripheral assistance from the British submarine Spark. In February Ise and Hyuga were also recalled and sailed on the 10th from Singapore, bound for Japan, carrying aviation spirit and other war materials. With such valuable cargoes the Japanese took great care to safeguard their passage and, by a combination of good luck and bad weather, both evaded numerous attacks by air and by submarine and reached Moji on the 19th. Haguro and Ashigara, and one old destroyer, Kamikaze, were now the only sizable warships left in the 10th Area Fleet to protect the troop evacuations. At this stage, the Japanese aimed to hold Java, Borneo, and Sumatra for as long as possible while planning their main defensive efforts in Malaya and Indochina. Consequently, they began withdrawing their garrisons from the outlying islands of the Moluccas, Timor, the Lesser Sunda Islands, and the scattered islands of the Panda and Arafura Seas. Anticipating a similar evacuation of Japanese garrisons in the Andaman and Nicobar Islands, Admiral Arthur Power's East Indies Fleet had dispatched destroyers on a series of anti-shipping sweeps in the Andaman Sea, successfully destroying several relief convoys. On May 10, Fukudome decided to commence the evacuation of the Andaman Islands, dispatching Vice-Admiral Hashimoto Shintaro's heavy cruiser Haguro and destroyer Kamikaze to deliver supplies to the islands and return with troops back to Singapore. Additionally, a secondary convoy consisting of one auxiliary vessel and one subchaser was organized to perform the same mission for the Nicobar Islands. As Allied intelligence uncovered these plans, Vice-Admiral Harold Walker's Force 61, primarily composed of the battleships Queen Elizabeth and Richelieu and four escort carriers, sailed from Trincomalee to intercept the Japanese ships. However, the Japanese were unwilling to risk a battle, and upon receiving an air reconnaissance warning, they returned to Singapore. Nonetheless, Walker decided to remain in the area, awaiting reinforcements in case the enemy regained the confidence to launch another sortie. On May 14, Fukudome finally resolved to carry out the evacuation again, this time first sending forward his secondary convoy to the Nicobars. This force managed to reach the islands unmolested during the day and successfully embarked 450 troops before setting sail for Penang, although they were later spotted by a patrolling Liberator. In response, Walker dispatched the 21st Aircraft Carrier Squadron and the 26th Destroyer Flotilla to conduct an air and sea sweep off Diamond Point aimed at intercepting and destroying the enemy. On the morning of May 15, some Avengers encountered Haguro and Kamikaze as they returned to the Malacca Strait. As Captain Manley Power's destroyers rushed to the area, three Avengers launched by the escort carrier Shah attacked Haguro with bombs in the afternoon, causing minimal damage that only compelled Haguro to alter its course eastward. However, this diversion effectively allowed the destroyer force to intercept Hashimoto's convoy during the night. As the flotilla closed in on the enemy during the early hours of May 16, Hashimoto reacted desperately by fleeing at full speed to the north, thwarting Power's carefully laid ambush. Soon after, however, Haguro turned to port, crossing paths with the destroyer Venus, which was closing in at full speed from the west. Surprisingly, Venus failed to launch its torpedoes, prompting Hashimoto to turn south and back into Power's trap.  Haguro's violent turn away changed the situation dramatically. Saumarez now found the enemy racing down towards her port side at a relative speed of nearly 60 MPH. Kamikaze, following astern of Haguro, passed so close in front of Saumarez from starboard to port that Captain Power had to swing his ship hard to starboard and back to port again to avoid her. Kamikaze passed very close down Saumarez' port side and was taken under fire by both main and close range armament. Opening with star-shell, Saumarez shifted fire to Haguro herself at 0108, the enemy replying with main and secondary armament. The two enemy ships could now be clearly identified from Saumarez' bridge, Haguro at about 5,000 yards and Kamikaze about 2,200 yards range. ‘We had a glimpse of the cruiser by starshell, but now it was dark. She looked pretty big and her direction easy to see by her bow-wave and wash. Inclination vague but obviously broad. I thought she was going very fast. Her side was shining like a wet wall, with the reflection of her own starshell from behind us, I think.' To Lt. Reay Parkinson, also in Saumarez, Haguro ‘seemed to tower above us like a sky-scraper and her guns were depressed to their lowest angle'. Haguro's fire was accurate and splashes from near misses drenched the bridge personnel, binoculars and sound-powered telephones. But, as Captain Power philosophically remarked, ‘if you are only getting wet there is nothing to worry about'. However, Saumarez was unfortunately not merely getting wet. At about 0111, when Captain Power was just considering turning to fire, ‘one boiler got hit. There was a lot of steam and smoke amidships and a sort of queer silence. The ship was obviously slowing down and I thought she was going to stop.' Saumarez' torpedo tubes had been trained to starboard, ready for the bow attack, with torpedoes angled to run 70° left. There was no time to train the tubes to port. Captain Power swung his ship to port ‘like a shotgun' and at 0113, as Saumarez was slowing down but still swinging hard to port, a salvo of eight torpedoes was fired at Haguro's beam, at a range of 2,000 yards. Still under heavy fire, Saumarez continued her turn to port to open the range, telegraphs being put to ‘Full Ahead' to get the utmost speed from whatever engine power remained. A minute after Saumarez' attack, Verulam made an unmolested attack from 2,000 yards on Haguro's port bow, firing eight torpedoes. Saumarez and Verulam were rewarded by three hits, shared between them  ‘very distinct, three gold-coloured splashes like a Prince of Wales' feathers, more than twice as high as her bridge'. Now Haguro was under fire from the destroyers and everywhere she turned there was another destroyer waiting. At 0125 Venus fired six torpedoes and scored one hit. Two minutes later Virago, ordered by Captain (D) to ‘Finish her off', fired a salvo of eight torpedoes and obtained two hits. She reported that the cruiser's upper deck was now awash. Missed torpedoes were racing all over the battle scene; in Venus, at the height of the action, the Engineer Officer and the Chief ERA in the engine-room actually heard the whirring sound of two torpedoes passing very close along the ship's side. Saumarez had retired some five miles to the north-west to collect herself and examine damage. The engine telegraphs were still at ‘Full Ahead', and Saumarez withdrew further than Captain Power had intended. Vigilant had been rather ‘left in the cold' and squeezed out by the other destroyers and was not able to attack until 0151 when she fired eight torpedoes, with one probable hit. Haguro was lying motionless in the water, in her last throes. ‘The rest of the flotilla were snarling round the carcass like a lot of starving wolves round a dying bull. I was too far away to make out what was going on and told them all except Vigilant (who I knew had torpedoes) to come away and join me, with a view to getting formed up and the situation in hand. Of course they did nothing of the sort. I should not have done myself.' Venus was ordered to ‘Close and make a job of it' and at 0202 administered the coup de grace with her two remaining torpedoes. At 0206 Venus signalled that the cruiser had sunk. Haguro had gone, in a position about forty-five miles south-west of Penang. Fifty miles away, Cumberland and Richelieu had had tantalising glimpses of starshell and lights but were too late to take part. Saumarez transmitted Vs for Victory and Captain Power signalled: ‘Pick up survivors. Stay no more than ten minutes.' Kamikaze sustained slight damage from the gunfire but managed to escape, returning the following day to rescue approximately 320 survivors. Nevertheless, over 900 Japanese soldiers lost their lives in the battle, including Vice-Admiral Hashimoto and Rear-Admiral Sugiura Kaju. While the evacuation of the Nicobar Islands was successful, the evacuation of the Andaman Islands proved to be a resounding failure. By the end of the war, with the food situation in the islands becoming critical, the Japanese committed several atrocities against the civilian population. This included the transportation of 300 so-called “useless mouths” to the uninhabited Havelock Island, off South Andaman, where all but eleven of them perished. I would like to take this time to remind you all that this podcast is only made possible through the efforts of Kings and Generals over at Youtube. Please go subscribe to Kings and Generals over at Youtube and to continue helping us produce this content please check out www.patreon.com/kingsandgenerals. If you are still hungry after that, give my personal channel a look over at The Pacific War Channel at Youtube, it would mean a lot to me. During the intense Battle of the Malacca Strait, Japanese forces attempted a desperate evacuation, facing relentless Allied attacks. Despite fierce resistance, the Allies advanced strategically, leading to significant Japanese losses. Caught in critical confrontations, the Japanese ultimately succumbed, marking a pivotal moment in the Pacific war and shifting the tide toward Allied victory.

In aflevering 92 praten Gerard en Sietse over Rory McIlroy, jeugdgolf in Nederland en wordt er gebeld met China. Joost Luiten bereidt zich daar voor op een nieuw toernooi op de DP World Tour en de mannen zijn benieuwd hoe hij heeft gekeken naar de ontknoping van de Masters. Daarnaast belt Podje Golf met NGF-medewerker Chanti Janssen over jeugdgolf. Chanti vindt dat het op golfbanen veel weg heeft van een 'bejaardenhuis'. Wat moet er gebeuren om het percentage jeugdleden onder de 18 jaar (3%!) omhoog te krijgen? Luister nu naar aflevering 92!

In aflevering 89 praten Gerard en Sietse over het heel goed gelezen GOLF.NL artikel over betalen naar gebruik in plaats van onbeperkt speelrecht en HGE, eigenaar van al 14 banen in Nederland en daar gaat het niet bij blijven. Volgens sommige lezers is betalen naar gebruik gif voor de golfsport, terwijl de ondernemer van HGE claimt rentmeester te zijn en juist banen te behouden voor golf.Vaste medewerker Joost Luiten hangt aan de telefoon om te praten over coursemanagement en de stilteruime die naar hem vernoemd is op het NGF-kantoor... Luister nu naar aflevering 89 van Podje Golf!

In this episode, learn how certain foods can fuel or fight inflammation in your body. Discover why wild-caught salmon, with omega-3s and astaxanthin, is excellent for reducing inflammation and boosting energy. Explore how berries and hydrating fruits combat oxidative stress and support a healthy gut microbiome.   Dive into the benefits of grass-fed beef and pasture-raised eggs, which are rich in anti-inflammatory nutrients like CLA and butyrate and improve joint, brain, and gut health. Uncover the healing properties of bone broth, with its collagen and glycine, for joint pain and gut recovery.   Explore how extra virgin olive oil, avocado, and coconut oil provide anti-inflammatory fats essential for brain health, skin regeneration, and immune function. Learn why arugula and other bitter greens are crucial for liver detoxification and how cucumbers and celery enhance cellular hydration, helping you make informed choices to optimize health. In This Episode:  00:00 Introduction to Hybrid Fruits 01:04 Understanding Neuroplasticity and NGF 03:11 Top 10 Foods to Reduce Inflammation 04:14 The Impact of Diet on Inflammation 06:53 Wild Caught Salmon: A Nutrient Powerhouse 09:40 Benefits of Extra Virgin Olive Oil 11:37 Berries and Hydrating Fruits 18:05 Avocado: A Superfood 19:25 Bone Broth for Joint and Gut Health 21:40 Pasture Raised Eggs and Grass Fed Butter 24:36 Nutrient-Rich Vegetables 27:07 Grass Fed Beef and Other Meats 28:38 Coconut Oil and Coconut Milk 31:28 Conclusion and Final Thoughts     Are swollen legs or ankles slowing you down? Discover the power of Lymph System Support by Pure Health Research. Crafted with natural ingredients like dandelion extract, burdock root, and bromelain, this formula unclogs your lymphatic system, reducing swelling and supporting a healthy inflammatory response.   As a special offer, try Lymph System Support risk-free today and receive a complimentary bottle of curcumin extract. Visit GetLymphHelp.com/jockers to claim yours now. Say hello to renewed vitality and goodbye to discomfort!     Unlock the brain-boosting power of lion's mane with Purality Health's advanced nano absorption technology. This formula ensures full absorption of lion's mane's nutrients, proven to enhance memory, speed up thinking, and boost mood. Experience the remarkable benefits with a special buy-one-get-one-free offer available exclusively through Purality Health. For a limited time, visit lionsmanecomplex.com/DRJ     “Extra virgin olive oil is nature's aspirin. It's rich in oleocanthal, which is powerful at bringing down inflammation and reducing pain in the body.”  ~ Dr. Jockers     Subscribe to the podcast on: Apple Podcast Stitcher Spotify PodBean TuneIn Radio     Resources: GetLymphHelp.com/jockers Visit lionsmanecomplex.com/DRJ     Connect with Dr. Jockers: Instagram – https://www.instagram.com/drjockers/ Facebook – https://www.facebook.com/DrDavidJockers YouTube – https://www.youtube.com/user/djockers Website – https://drjockers.com/ If you are interested in being a guest on the show, we would love to hear from you! Please contact us here! - https://drjockers.com/join-us-dr-jockers-functional-nutrition-podcast/ 

Toen Joost Luiten zijn debuut maakte op de Europese Tour had hij een hardloper aan zijn tas: Eric Brommert. In Rotterdam bekend als de man op de motor tijdens de Rotterdam Marathon en van hardlooppodcast De Pacer. In de eerste maanden op de Tour was het welkom voor Brommert en Luiten allerminst hartelijk door de oudere golfers. Na drie jaar stopte hij, ging aan de slag voor de NGF om te werken met jonge talentvolle amateurs die prof wilde worden. In de Seve Podcast vertelt Eric aan Jacob, Rick en Etienne over golfer met Rory, rookie caddie fouten, het pamperen van talent en veel meer. Luister net als de onze hosts ademloos mee.

Scotsman Iain Forrester has been a golf professional since 1983, moving to The Netherlands to become the Head Professional at Hoenshuis Golf & Country Club in Limburg. Iain believes that “……a PGA Professional needs to have a diverse skillset – a jack of all trades and a master of one or two. That's what I've tried to do with my career, to be as flexible as possible, learn as many skills as possible and then have a niche that separates you from others.” Iain's particular niche of choice focusses on maintaining and preserving the history of golf, in particular the way it was played in the past with wooden hickory clubs. Iain repairs and restores hickory equipment for fellow collectors while also suppling sets for hickory events throughout Europe. As if that's not enough he has also written extensively about hickory golf and golf history in general. Safe to say he's a great man to have on the pod to talk about on all things relating to hickory and Dutch golf. Iain's website can be found here (https://hickoryclubs.eu/) The Golfika article on the history of British Handicapping mentioned in the show can be found here (https://en.golfika.com/_files/ugd/72472f_cdab7f2449764a07881a5d9711ca6a67.pdf) - pages 6 - 11. Thanks for tuning in, we hope you enjoy listening. Episode music supplied under license from Epedemic Sound Shoreline Serenade - Dye O.1.1

Send us a message (with the best way to reply)The episode explores the transformative power of neuroplasticity for entrepreneurs, emphasizing its role in overcoming self-doubt and achieving success. Listeners learn about integrating hypnosis and specific supplements to optimize brain function and resilience.• Understanding neuroplasticity as a tool for growth • Real-life applications of neuroplasticity in business • The synergy of clinical hypnosis and neuroplasticity • Importance of nerve growth factor (NGF) for brain health • Recommended supplements for enhancing neuroplasticity • Integrative health strategies for lasting success • Offer for a complimentary consultation on integrative health and hypnosisLooking for daily support for your wellness, weight-loss and longevity questions? If you're the kind of entrepreneur that values your health as your greatest asset, naturally you'll want to join, and invite your friends, family and colleagues to our thriving community where you'll feel loved, supported, seen and heard! JOIN HERE!Support the showAs a token of gratitude, of course you're interested in these FREE and powerful resources: > Naturally, you'll want to join our Love Energy Wellness Community and Support Group for daily support! > You might be wondering just how full your Toxin-Tank may be: Take your FREE Toxicity Assessment to find out - no email required > You'll discover a new level of self, after your FREE 2-Part audio training for Confidence! > As you already know, you can lean more about Integrative Health on our Blog > I know you're concerned about your future. Schedule your FREE Consultation with Jeffrey > Health Coaches: add Functional Lab Testing to your practice today!

In this episode of Leadership on the Links, we welcome Jay Karen, CEO of the National Golf Course Owners Association (NGCOA), to dive into the pressing trends and challenges shaping the golf industry today. With over 28 years of experience in association management and a mission to champion golf course owners and operators, Jay shares his unique perspectives on workforce development, emerging trends, and the industry's advocacy efforts. Join us as we uncover strategies to navigate workforce challenges, explore revenue opportunities from alternative forms of play, and discuss the importance of advocacy in securing the future of golf. What You'll Learn in this Episode: Workforce Challenges and Opportunities: The golf industry must adapt to changing labor market dynamics by improving workplace culture and modernizing employment practices. Alternative/additive forms of play like simulators and night golf offer exciting revenue opportunities but come with operational challenges. Post-pandemic, sustained demand for golf has led to more aggressive pricing strategies and a shift toward "offense" in business planning. Despite positive performance metrics, advocacy remains critical to address legislative and regulatory challenges facing the industry. A coordinated, industry-wide effort on workforce development and recruitment, beyond individual associations' efforts is required to move the needle. Soundbites: "We have 15,000 small businesses around this country that are robust small businesses. They're in every community in America, and we get overlooked in some way." "We rested on the laurels of love of the game, and we're seeing, generationally now, two generations later, honestly, that the value system of people that want to work today is not the same as what it was 30, 40, 50 years ago." Quotes: "We've completely changed, the high demand has caused a complete mental shift towards what can I do with my business, and let me see what's possible with it instead of playing defense, we're on offense." "We have an entire television channel dedicated to our game. We have hundreds of millions, and if you look at the NGF research of how many people engage with the game in some way, as a fan, I might watch a clip of the Masters or Claygolf or I go to top, whatever." "If we want better people that are trained, better prepared people into the golf industry, we got to compete." "We get to have an enormous impact on an entire industry from one little office, and that's pretty special." "We're on offense. And four and a half years, almost five years into this now, we're still playing offense. And as business owners operators, holy cow, that is what you want to do." Resources Mentioned in the Episode: National Golf Course Owners Association (NGCOA): Website Connect with Jay Karen on LinkedIn - https://www.linkedin.com/in/jaykaren/ 

We beginnen uiteraard met ons eigen golf, waar we eerst de ‘clash of the titans' bespreken tussen Paul en Martijn op Amelisweerd. Het bleek een mooie herfstwedstrijd tijdens een van de laatste mooie dagen van dit golfseizoen. Terloops komt nog even ter sprake welke spelvorm het beste is als je gedwongen ‘langzaam' moet lopen. We sluiten af met Rogier die gespeeld heeft op de Links Valley en het Delfland Open. Hij speelde met een WGTF pro waar hij zich enigszins over verbaasde en het vleespakket voor de derde prijs vonden we ook niet erg ‘woke'. We sluiten af met ons cijfer voor de baan Delfland en bespreken een tip van een luisteraar, het Rijnmond Open. We vervolgen de podcast met een analyse van de Presidents Cup waarbij de grootste criticaster Paul nu erg enthousiast was en het meest heeft gekeken van alle podcasters. Het promofilmpje van Montreal viel ons enigszins op en natuurlijk en het mooie was dat er ook wat animositeit was tussen beide teams en dat versterkte het teamgevoel, met name door types als Tom Kim. Verder vielen een aantal keuzes van Mike Weir en het publiek in Canada op en we sluiten af met de reclames op Ziggo. We sluiten de toernooiensectie af met het Spaans Open waar een volledig Spaanse laatste flight aan de finaleronde begon. Rahm als favoriet bleeflang in de race maar de onbekende Hidalgo ging er met de zege vandoor. De laatste drivable par 4 hole viel erg op en ook de playoff tussen Hidalgo en Rahm. Hidalgo was erg likeable omdat hij twee jaar terug nog als supporter Rahm aan stond te moedigen. Het gesprek ontaard ook nog even in een LIV discussie omdat er veel LIV spelers mee deden in Spanje. We sluiten af met de prestatie van Huizing. In de korte ronde schiet het weer alle kanten op en gaat het over hagelstenen op de golfbaan, een onderzoek door de NGF, bespreken we toekomstige Ryder cup selecties met wellicht alleen Denen. We sluiten af met de op een na meest gespeelde bal in de VS en ‘curieuze' golfmomenten van ons als podcasters. 0:00 – 15:34 Onze eigen golfavonturen 15:34 – 44:32 De Golftours 44:32 – 1:04:46 Korte Ronde 1:04:46 – 1:05:18 Raad de Speler 37

In hole 35 bespreken we de ronde op De Hoge Kleij die Peter, Paul en Rogier hebben gelopen met een borrelhap in de tijdelijke 19e hole nu het clubhuis wordt gerenoveerd. Op de Tours was er een vol programma: Het Iers Open op Royal County Down werd een prooi voor Rasmus Hojgard, bij LIV won Rahm het individual championship, Kizzire het eerste fall series event en de Amerikaanse vrouwen wonnen de Solheim Cup. Kuchar, Tiger, het werkwoord Keegan Bradley, de NGF, Frits van Eerd en natuurlijk weer LAB putters passeren de revue in de korte ronde. Tot slot weer de Raad de Speler. 0:00 – 12:08 Ons eigen golf 12:08 – 51:15 De golftours 51:15 – 1:08:30 Korte ronde 1:08:30 – 1:09:07 Raad de Speler 35

Waarom gaat alleen Anne van Dam naar de Olympische Spelen? Wat is er mis bij NOC*NSF of wat heeft de NGF verkeerd gedaan? Hoe kan het dat Joost Luiten niet naar Parijs gaat? Of Darius van Driel of Dewi Weber? Terwijl ze zich wel hebben gekwalificeerd. Jacob en Rick duiken in deze zaak en komen tot genoeg argumenten om meer Nederlanders in Parijs in actie te zien op de golfbaan.Ondertussen is in Amerika een hevig debat gaande tussen twee presidentskandidaten. Die op de golfbaan nog een strijd lijken uit te willen vechten.Schuif aan en luister mee!

In aflevering 82 van Podje Golf is de data scientist van de NGF, Ruth van Dongen, te gast. Uitgebreid onderzoek heeft aangetoond dat het aanbod in lidmaatschappen niet aansluit op de vraag van de golfers in Nederland. Zo zou slechts 34% van de huidige clubleden kiezen voor onbeperkt speelrecht als er andere opties zouden zijn. Van de golfers die niet lid zijn van een club met gras zegt zelfs 84% dat er geen geschikt aanbod is. Gerard en Sietse praten met econometrist Ruth over de voor- en nadelen van prijsdifferentiatie. Wat is de kritiek op het aanbieden van andere lidmaatschappen dan alleen onbeperkt speelrecht? En waarom hebben zoveel clubs koudwatervrees als het gaat om het aanbieden van meerdere lidmaatschapsvormen? Natuurlijk belt Podje Golf ook weer even met vaste medewerker Joost Luiten, die zich klaarmaakt voor een hectische week op The International. Als klap op de vuurpijl zijn de laatste weekendtickets voor het KLM Open te winnen, dus luister nu aflevering 82!

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We komen nog even terug op de NGF perikelen. We hebben het natuurlijk ook over golf. De PGA bleek uiteindelijk een tweestrijd tussen een man en een jongetje. Ook bij de vrouwen waren er 2 duidelijk beter dan de rest. Wat heet. Nummer 3 had maar liefst 15 slagen meer nodig dan de winnares, Rose Zhang. Verder een voorbeschouwing op het tweede major van het jaar, het PGA Championship en we hebben het over de bestuurlijke perikelen binnen de PGA organisatie. Het rommelt daar. 

Er zijn van die toernooien die eigenlijk niet gespeeld zouden moeten worden. Zo hadden we er deze week twee. Maar gelukkig waren de contentgoden ons weer gunstig gezind en kwam follow the money met een pittig verhaal over de NGF. Daar duiken we natuurlijk lekker diep in bij gebrek aan beter.

103 Jahre alt wurde Rita "la professoressa" Levi-Montalcini, Entdeckerin des Nervenwachstumfaktors. Zur Welt kam die Medizin-Nobelpreisträgerin am 22.4.1909 in Turin. Von Steffi Tenhaven.

This episode isa snippet from the late 2023 Veterinary Pain Management Workshop hosted by IVDI, which offers a deep dive into nerve growth factor inhibitors, focuses on the cutting-edge therapeutic agents, Salencia for cats and Librella for dogs, addressing their mechanism and impact on pain management. Dr. Mark Epstein, a renowned pain management expert, shares insights from a 2023 workshop, breaking down complex mechanisms and their practical applications in clinical settings.   Main Talking Points: Introduction to Nerve Growth Factor (NGF) and its inhibitors. The biology and impact of NGF on pain pathways. Clinical use and observations with Silencia in cats and Labrella in dogs. Potential concerns and ongoing questions about NGF inhibitors. Co-administration with NSAIDs and its implications. Interesting Quotes: "NGF is largely responsible for amplifying neurogenic inflammation, making it a prime target for therapeutic intervention." "Silencia and Labrella offer significant improvements in mobility and quality of life for cats and dogs suffering from osteoarthritis." Timestamps: 0:00 - Introduction to the episode 1:30 - Speaker introduction: Dr. Mark Epstein 2:00 - Overview of nerve growth factor inhibitors 4:00 - The science behind NGF and pain management 6:00 - Clinical observations with Silencia and Labrella 8:00 - Addressing concerns and unanswered questions 9:30 - Discussion on co-administration with NSAIDs   Love Veterinary Dentistry?

Faaaaaaaala Nerds, Geeks e Freaks!!!!!Chegou mais um NGFCast! la vem um podcast direto do Eternia para todo o Universo!Vamos começar 2024 com um dos temas mais recorrentes do NGFCAST: HE-MAN!Kdu - O Nerd mais Fraco do Mundo do Canal @ngfsemlimites la do Youtube e Adriano Holmes o Indio Nerd do Norte la da Twitch da @ngfsemlimites recebem: Murilo Sala do Canal A Hora do Game e Phelipe do site Não sei Nada pra debater o que achamos da segunda temporada do polemico He-man da Netflix!Pegue Sua espada espada do poder e venha gritar EU TENHO A FORÇA junto com a gente! E finalmente saber a resposta para a pergunta do ano: QUEM É DESPARA??Confira o Quadrinho que originou DESPARA ( leitura imersiva e exclusiva da NGF )https://www.youtube.com/playlist?list=PL3pTJob_CVKYxHPYtnEPaAFN2jOZ4AMnVCompre os Produtos da Magalu através do nosso Link:https://www.magazinevoce.com.br/magazinengfsemlimites/Escreva pra gente: contatongf@gmail.com ou contato@ngfsemlimites.com.brSe você começou , está pensando em fazer ou já tem um PODCAST e quer fazer parcerias, entre para a LIGA DOS CRIADORES:https://www.instagram.com/ligadoscriadores/Edição e Arte na Vitrine: NGF Edições Profissionais de Podcast.Edite seu Podcast Conosco:https://ngfsemlimites.com.br/edicoesprofissionaisdepodcast/#NGFPOWER Hosted on Acast. See acast.com/privacy for more information.

Aflevering #76 van Podje Golf staat in het teken van jeugdgolf. Het gaat dramatisch slecht met het aantal golfers onder de 18 jaar in Nederland, en daarom is er een groot jeugdplan opgesteld om het tij te keren. Alexander Renders van de NGF is te gast en komt een toelichting geven op het plan waarmee het aantal jeugdleden in 5 jaar van 3% naar 8% moet stijgen. Er wordt nog even teruggeblikt op de vorige aflevering over LIV Golf die veel boze reacties opleverde. Natuurlijk bellen Gerard en Sietse met Joost Luiten om te horen hoe hij naar jeugdgolf kijkt. Ook komt de overwinning van collega Darius van Driel ter sprake. Luister nu aflevering 76!

In alweer aflevering 4 hebben we het over onze eerste meters in de baan van dit seizoen, de aanloop naar de NGF competitie, het Wast(ed) Management Open, Parels in Qatar, golf als jurysport bij LIV. We behandelen vragen van luisteraars, kijken vooruit naar de comeback van Tiger en meer!

Een dagje eerder dan dat je van ons gewend bent, maar Martijn moet zo nodig naar het NGF congres. We hebben het natuurlijk over Wyndham Clark ... (wie?) de regen en storm op Pebble Beach, Pavon die weer vriend en vijand verbaast, Luiten die de cut niet haalt, Huizing heeft een goede week op de troosteloze baan in Bahrein, Anthony Kim, Full Swing en nog veel meer ....

Menig golfbaan heeft inmiddels een driving range met een trackman systeem erop. Bedoeld om te trainen met data en natuurlijk leuk om spelletjes te spelen.Jacob, Rick en Etienne doken in de games van Trackman om te kijken wat de leukste spelletjes waren. Of waar ze het meest aan hadden in een training.En er is mogelijk een vacature bij NGF: bondscoach. Wie anders dan Jacob zou de ideale man voor die baan zijn. Maar wil hij wel of wil hij liever iets anders?

Daar zijn we weer! Na twee weken afwezigheid beginnen we natuurlijk met het nieuws van de de afgelopen tijd. En dat is nogal wat. De onrust binnen de NGF, Tiger weg bij Nike, Keith Pelley weg bij de DP World Tour, Martin Slumbers weg bij de R&A, LIV nieuws, babynieuws en nog veel meer. Uiteraard blikken we uitgebreid terug op het eerste toernooi op de DP World Tour, het tweede toernooi op de PGA en nog veel meer ....

Description: Listen in as Jay Karen (CEO, NGCOA) and Don Rea, PGA (Vice President, PGA of America) recap a busy past few months, take a peek at what's in store for 2024, and sit down with special guest Greg Nathan, President and Chief Operating Officer of the National Golf Foundation (NGF). Jay, Don and Greg react to eye-opening industry data, discuss their takeaways from NGCOA's recently released 2024 Golf Industry Compensation and Benefits Report, and look ahead to the new year as NGF has announced Greg Nathan will take the helm as their CEO starting January 1.   Then, host Michael Williams welcomes Lauren Dudding, Sr. HCM Account Executive for Paylocity, for a House Chat. Discover how Paylocity has simplified the process of HR by providing a mobile-first approach to their business systems. Learn how managers, supervisors, and employees have everything at their fingertips, from paystubs to expense reports, training videos, and social collaboration tools all in one place. Are you looking for an effective way to save time and streamline your operations?  

Ted Eleftheriou is a member of the Professional Golfers' Association of America and works for the National Golf Foundation (NGF) as Vice President of Player Development and Engagement. He has emerged and is recognized as a leading expert in the areas of player and business development particularly in sports, with an emphasis on golf.He travels the globe conducting informative, engaging, and impactful keynotes, seminars, and workshops on how to grow business and revenue. Since 2019, he's also been busy presenting on many video platforms. His best known topics are on leadership, marketing, and customer engagement.In addition to speaking, he leads NGF's Welcome2Golf initiative, which focuses on growing adult golfer participation by creating and training leaders in the golf industry.Prior to NGF, some of Ted's career highlights include: Director of Golf Program Development for the PGA of America; owner of two successful golf academies; opened and managed 41 Nike Golf Learning Centers throughout the United States; and worked in the film industry as a freelance producer.Stalk Ted to learn more about speaking at your next event and/or how he can help you achieve your business and professional goals.@tedeleftheriou@welcome2golf@nationalgolffoundationContact Coach Mo@coachmogolfprowww.coachmogolfpro.commgesualdi@stjohnsgolf.comThe Golf Academy at St. Johns Located at St. Johns Golf & CC in St. Augustine/St. Johns, FL@thegolfacademy_st.johnswww.stjohnsgolf.com

Welcome to a fascinating episode of Golf Sustainability! In this enlightening conversation, your host, John Failla, engages in an in-depth dialogue with Greg Nathan, the President and Chief Executive Officer of the National Golf Foundation (NGF). Together, they explore the dynamic world of off-course golf and its profound impact on the golf industry. Diving headfirst into the discussion, John and Greg traverse the various facets of off-course golf, encompassing driving ranges, the exhilarating world of golf entertainment exemplified by Topgolf, and the cutting-edge realm of simulator golf. A particular focus emerges on the role these activities play in cultivating "shot euphoria," that gratifying sensation integral to the game of golf. Drawing from his extensive expertise, Greg Nathan presents data on the remarkable growth of off-course golf participation and underscores the pivotal role of off-course golf in making golf more accessible and enjoyable, particularly for newcomers and casual players. Unearthing the driving forces behind the meteoric rise of off-course golf, John and Greg dissect the allure of these venues, from their accessibility and entertainment  factor to the engaging gaming elements, and seamless integration of technology. In particular, the discussion spotlights the transformative impact of golf entertainment hubs like Topgolf. Furthermore, Greg Nathan accentuates the pressing need for traditional golf courses to evolve, embracing a more welcoming and inclusive approach that breaks down the barriers preventing newcomers from transitioning to on-course golf. This conversation doesn't stop at showcasing the success of off-course golf; it also sheds light on the harmonious coexistence of off-course and on-course golf. Many who partake in off-course activities find themselves drawn towards the allure of a traditional golf course. This symbiotic relationship underscores how off-course golf is a gateway that introduces individuals to the broader golfing experience, paving the way for potential migration to on-course play. In essence, this episode delves deep into the heart of the evolving golf landscape, emphasizing the pivotal role of off-course golf in shaping the sport's future. The insights shared by Greg Nathan, the NGF President & CEO, and John Failla are invaluable, providing listeners with a profound understanding of how off-course golf is redefining the game and expanding the horizons of golfing enthusiasts. So, join us for this illuminating episode as we explore the captivating world of off-course golf and its transformative influence on the golf industry. Topics Covered: An Introduction to NGF and Off Course Golf Participation Trends Timestamp: [00:00:00] to [00:18:00] Summary: Discuss the growth and trends in off-course golf participation, including the different segments such as traditional driving ranges, golf entertainment (e.g., Topgolf), and simulator golf. Impact of Off Course Golf on On Course Participation Timestamp: [00:18:00] to [00:27:00] Summary: Explore how off-course golf activities, like driving ranges, golf entertainment, and simulators, act as a gateway to on-course golf by removing barriers and providing a more accessible and enjoyable entry point. 3. The Impact of Off-Course Experience on Green Grass Golf Timestamp: [00:27:00] to [00:30:00] Discuss how individuals with off-course experience, such as traditional driving ranges, golf entertainment, or simulators, are more interested in green grass golf. Explore the statistics provided regarding the percentage of new golfers with off-course experience and the increasing trend over the years. Evolution of the National Golf Foundation's Role and Work  Timestamp: [00:41:00] to [00:42:00] Highlight the historical evolution of the National Golf Foundation's role, citing the example of the golf ball reconditioning program during World War Two. Discuss the organization's commitment to adapting to industry needs and the current focus on addressing challenges within the golf industry. Future Initiatives: Improving the Welcome to Golf Experience Timestamp: [00:43:00] to [00:45:00] Explore the NGF's plans for the "Welcome to Golf" program in 2023 and beyond. Discuss the organization's goal of creating a modern and approachable venue for individuals interested in taking up golf. Address the importance of making the golf course environment comfortable for new players and the missing element in existing online resources.   Resources and People Mentioned: National Golf Foundation (NGF) Fortnight - NGF Newsletter Topgolf   Connect with Our Guests Greg Nathan LinkedIn Connect with The National Golf Foundation  National Golf Foundation Connect With Golf Sustainability LinkedIn  Facebook  Instagram X (Twitter) Email Subscribe to Golf Sustainability Apple Podcast  Spotify  Google Podcasts  Note: Timestamps provided are approximate. Thank you for listening to the Golf Sustainability podcast. If you found this episode interesting, don't forget to subscribe and leave a review! For more insights and updates on sustainable energy solutions, visit our website and follow us on social media.

Hoe verliep (verloopt) de final stage Q school voor de Nederlanders in Spanje? en in Zuid Afrika ging het voor Joost Luiten qua concurrentie voor de PGA tourkaart niet de goede kant op. Dewi Weber vocht voor haar laatste kans voor rechtstreekse kaartbehoud op de LPGA, gedoe binnen de NGF, Mcllroy noemt Cantley een lul, het nieuwe LIV off season programma en nog veel meer ....

If you're holding grudges in a relationship, if you're keeping score for when someone let you down, I want you to STOP. Here's how to stop grudges getting in the way of forming long lasting, meaningful relationships.   BRAIN FACT:Nerve Growth Factor (NGF): A type of protein that places a key role in growth, development, and the maintenance of nerve cells in the nervous system. EXTRA READING Nerve Growth Factor Explained from Science Direct https://bit.ly/nervegrowthfactor . Watch ‘Response of Cells to Nerve Growth Factor' (NGF) from University of Massachusetts YouTube channel -  https://bit.ly/ngf-umass . LISTENER QUESTION: My mother has taken to undermining me in front of my partner and it's really upsetting. I am worried about my partner leaving me because of how my mother treats me. DO you have any advice on what I can do? LINKS:  Send your Listener question to info@dyfmpod.com  Follow @dyfmpodcast on IG  Follow @alexispredez on IG   Join the DYFM Facebook Group https://bit.ly/dyfm-group . Follow @listnrentertainment on IG  CREDITS Host: Alexis Fernandez           Executive Producer & Editor: Elise CooperDigital Producer: Zoe Panaretos and Nick BarrettDYFM Social Producer: Shania MaguaManaging Producer: Sam Cavanagh  Find more great podcasts like this at www.listrnr.com/  See omnystudio.com/listener for privacy information.

Desde que España se incorporó al programa europeo de defensa FCAS en 2019, hemos emprendido un viaje hacia el futuro de la seguridad y la defensa en Europa. FCAS, que significa "Future Combat Air System" o Sistema de Combate Aéreo del Futuro, es un programa ambicioso y transformador que involucra a varios países europeos, con Dassault Aviation liderando la coordinación en Francia, Airbus DS en Alemania y nosotros, Indra, asumiendo un papel fundamental en España. Este programa no solo representa un hito en la cooperación militar europea, sino que también es una oportunidad para definir el futuro de la tecnología y la industria de la defensa. El corazón de FCAS es el "Next-Generation Weapon System" o NGWS, que engloba un Caza de Nueva Generación (NGF) y múltiples Operadores Remotos (RC), todos interconectados a través de la "Combat Cloud" o Nube de Combate, un elemento crucial que permite la colaboración y la coordinación entre todas las plataformas.En este episodio de "Engineering The Future Talks" junto a cuatro grandes profesionales de Indra, Pelayo Menéndez, Laura Navarrete, Ana Álvarez Mellado y Alejandro Serrano, te invitamos a sumergirte en el intrigante mundo del programa FCAS. Exploraremos los siete pilares fundamentales que sustentan este proyecto, cada uno con un papel esencial en la construcción de un sistema de sistemas revolucionario. Desde el avión de nueva generación y su motor, hasta los operadores remotos, la nube de combate, laboratorios de simulación, sensores y tecnologías de baja observabilidad; todos estos elementos trabajan juntos para llevar la defensa europea al siguiente nivel.El Programa FCAS no es solo una hazaña tecnológica; es también una oportunidad para fortalecer la industria de defensa en España y contribuir al desarrollo industrial y tecnológico de nuestro país. El compromiso de Indra como Coordinador Nacional del programa es un testimonio de nuestra dedicación a defender los intereses estratégicos de España y de contribuir al crecimiento económico y la creación de empleo altamente cualificado.Acompáñanos en este apasionante viaje por el futuro de la defensa europea, donde la cooperación, la innovación y la visión estratégica se combinan para moldear un mañana más seguro y tecnológicamente avanzado.Si llegaste hasta aquí, te invitamos a seguirnos en nuestras redes para mantenerte al día:LinkedIn: https://www.linkedin.com/company/indra/Twitter: https://twitter.com/IndraCompanyInstagram: https://www.instagram.com/indracompany/Youtube: https://www.youtube.com/@theindracompany

Ep. 73 - New treatments for arthritic pets - Show NotesOur pets can suffer from arthritis, just like their human owners. For years, the only treatment has been non-steroidal anti-inflammatory drugs (NSAIDS.) However, two drugs have recently been approved by the FDA for our pets.Dr. Tamara Grubb returns to the podcast to explain how these new drugs, utilizing the science of monoclonal antibodies, are revolutionizing the treatment of osteoarthritis for our pets.Here are links to information we talked about today:Listen to Dr. Tamara Grubb's first visit to The Family Pet Podcast in Episode 35This explainer from the Cleveland Clinic explains monoclonal antibodies in human medicine and is a good insight into what the future might hold for pet medicineDog owners can learn about LibrelaCat owners can learn about SolensiaZoetis announced the U.S. commercial launch of Librela (bedinvetmab injection), which the company says is the first and only anti-NGF monoclonal antibody treatment to control canine osteoarthritis pain. The product in May received approval from the FDA. Got a question for Michael and Stephen? Run across something interesting you want to share with the show? Do you have a topic idea for a future episode? Send it to us at thefamilypetpodcast@gmail.com. 

Aflevering 67 gaat over het imago van golf. Gerard en Sietse vullen het imago onderzoek in dat de NGF doet om meer te weten te komen over het beeld dat golfers en niet-golfers hebben van de sport. Maar is golf wel een sport, of is het een lifestyle? Als ze een ding zouden mogen veranderen aan golf, wat zou dat dan zijn? Waarom is Gerard voorstander van golfclubjes waar vrouwen niet welkom zijn? Wordt de Johan Derksen van Podje Golf nu eindelijk gecanceld? Natuurlijk gaat het ook over de 'ruil-je-rode-broek-in-weken'. De campagne zorgde voor aardig wat ophef onder golfers en kreeg veel aandacht in de media. Hoe kijkt marketingdirecteur Danielle Wallet terug op de actie? Doe via podje@golf.nl een suggestie om het imago van golf te veranderen en win een doosje Titleist ballen! Luister dus nu Podje Golf 67!

These mushrooms gummies contain 10 difference amazing varieties:Maitake: Maitake mushrooms may support cognitive health by helping to regulate blood sugar levels, which can in turn promote stable energy levels and mental clarity.Shiitake: Shiitake mushrooms contain compounds that support the immune system. By keeping the body healthy, they indirectly contribute to overall cognitive function.Lion's Mane: Lion's Mane mushrooms have shown potential in promoting nerve growth factor (NGF) production, which is important for the growth and maintenance of brain cells, potentially aiding in memory and cognitive function.Reishi: Reishi mushrooms are known for their calming and stress-reducing properties, which can improve mental well-being and cognitive function.Cordyceps: Cordyceps mushrooms may boost energy levels and enhance oxygen utilization in the body, potentially improving mental clarity and focus.Chaga: Chaga mushrooms are rich in antioxidants, which help protect brain cells from oxidative stress and may support cognitive health.Turkey Tail: Turkey Tail mushrooms contain polysaccharides that may have immunomodulatory effects, indirectly benefiting cognitive function by promoting overall health.White Button Mushroom: White Button mushrooms are a good source of selenium, which can have neuroprotective effects and support brain health.Black Fungus: Black Fungus mushrooms contain iron, which is essential for oxygen transport in the blood. Proper oxygenation of the brain is crucial for cognitive function.Royal Sun Mushrooms: Royal Sun mushrooms, like other varieties, are a source of essential nutrients and antioxidants, which can support overall brain health and cognitive function.And the ULTRA MIND contains DMAE, which I find pairs perfect with the mushrooms.Simply click the link in my bio & scroll to “Lucky Finds” Store

Noteefy is an automated tee time booking assistant for golfers and golf courses; customized to deliver better course revenue, operations, and customer experience. On this episode of The Wednesday Match Play Podcast presented by Mindful "U", Co-Founder, CEO Jake Gordon introduces Noteefy, explains what it does, how golf course operators can get involved, and his experience working with clubs like Streamsong, Chambers Bay, and Sand Valley. He also talks about their partnership with PGA Southern California and NGF and we rap on custom QR codes. This was an unforgettable conversation and an honor having Jake on this show. Let's tee off.

De vijfde aflevering van Uniek Sporten Vandaag gemist? Met FGS-directeur Nike Boor als sidekick, ging Robert Denneman deze aflevering in gesprek met de gasten over een rolstoelfietstocht naar Santiago de Compostella, het EK Golfen met een aanpassing, een nieuw partnership en rolstoelbasketbal. Te gast in de uitzending waren Wim en Marga van den Berge, die momenteel op de rolstoelfiets onderweg zijn naar Spanje; Alexander Renders, Teammanager Sportparticipatie bij de NGF; Jeroen Zaal, directeur van ActivLease; en rolstoelbasketbalster Bo Kramer. Uniek Sporten Vandaag hoor je elke tweede donderdag van de maand tussen 13:00 en 14:00 uur. In een uur tijd wordt je helemaal bijgepraat over alles wat met aangepast sporten te maken heeft. Met het laatste nieuws, interviews en studiogasten, van topsport tot breedtesport. Het programma is live te horen op ALLsportsradio en is na afloop als podcast beschikbaar via de bekende podcastkanalen. Uniek Sporten Vandaag wordt gemaakt in samenwerking met Fonds Gehandicaptensport en ParaWatcher.

Van 25 t/m 28 mei wordt de 103de editie van de KLM Open gespeeld op Bernardus Golf in Cromvoirt. Het grootste jaarlijks terugkerende internationale golftoernooi van Nederland is onderdeel van de DP World Tour en is daar één van de oudste toernooien. Wat kunnen we verwachten van deze editie? We blikten erop vooruit met Gordon Machielsen van de NGF en Golf.nl. Presentatie: Robert Denneman

Momenteel wordt de B-NL Challenge Trophy gehouden op de Twentsche Golfclub. Het is een internationaal topgolftoernooi voor Europees talent en voormalige topspelers. De Twentsche Golfclub is voor het eerst gastheer van de Challenge Tour. Wat gebeurt er allemaal en wat kunnen we verwachten van het finaleweekend? We gingen erover in gesprek met Gordon Machielsen van de NGF en Golf.nl. Presentatie: Robert Denneman

It's been two years since bedinvetmab was launched as a treatment for the pain associated with osteoarthritis - quickly followed by frunevetmab. During that time Matt has lectured around the world on the topic. This podcast brings together a number of questions that have been raised as part of those lectures - and we always say that if someone has a question, then 10 are people are thinking the same thing! After this podcast you will have a better understanding of the anti nerve growth factor agents. If you have questions, we would love to help. Please use the contact box to send us a message. Don't forget that we offer a telemedicine service - so for case advice, please ask for our help! Reflective learning What further questions does this podcast content raise for you? How will this understanding impact the management of your current and future patients? Learning actions Revise the mechanism of action of anti nerve growth factor agents (both references below) Review the data sheet (summary of product characteristics) for bedinvetmab (Librela/Beransa) and frunevetmab (Solensia). Practice discussion As a practice team do we feel that anti-NGF agents are a first line treatment for OA in dogs and cats? References Enomoto M, Mantyh PW, Murrell J, Innes JF, Lascelles BDX. Anti-nerve growth factor monoclonal antibodies for the control of pain in dogs and cats. Vet Rec. 2019 Jan 5;184(1):23. doi: 10.1136/vr.104590. Epub 2018 Oct 27. PMID: 30368458; PMCID: PMC6326241. Schmelz M, Mantyh P, Malfait AM, Farrar J, Yaksh T, Tive L, Viktrup L. Nerve growth factor antibody for the treatment of osteoarthritis pain and chronic low-back pain: mechanism of action in the context of efficacy and safety. Pain. 2019 Oct;160(10):2210-2220. doi: 10.1097/j.pain.0000000000001625. PMID: 31145219; PMCID: PMC6756297.

In pharma, it takes many failures to achieve one breakthrough. Dompé, a family-owned global biopharmaceutical company, focuses on long-term success, knowing those wins impact thousands or even millions of patients.Gianluca Rossetti, Strategic Planning & Corporate Business Development Director at Dompé, was drawn by the company's ambition, passion, and commitment to innovation and science.Today, he uses his management consulting background to guide the company's business strategy, lead strategic projects, and provide direction as the company expands its ophthalmology portfolio.With podcast host and retina surgeon Firas Rahhal, MD, Gianluca shares Dompé's vision and gives details into its pipeline. He also provides insight into what's kept the company going for over 130 years—through two world wars and two pandemics.A clue: as a family-owned company, Dompé focuses less on quarterly results and more on long-term impact.Listen to the podcast today to discover:Gianluca's professional background: why he chose to start in management consulting and what brought him to pharma, and most recently, what brought him to Dompé.Dompé's criteria for drug discovery and development.The pros and cons of running a family-owned pharmaceutical company vs a large publicly-owned corporation.How Oxervate (cenegermin-bkbj), the first FDA-approved treatment for neurotrophic keratitis (NK), has performed over the past five years.What else is Dompé has planned for NGF products, including front- and back-of-the-eye indications.Dompé's plans to expand its presence in ophthalmology.Details into the Exscalate program – its platform that applies artificial intelligence to drug discovery ophthalmic innovation.[Press Play]

I think there's a saying that if you see a newspaper headline with a yes/no question, the answer is always no. I don't know who reads newspapers anymore, but that's true of today's NGF title. Stick around for the extended album cut of the VM from Jared song AND an extra Easter egg of the isolated vocal track for a real "Behind the Music" look at the making of. Fair warning- You just can't un-hear that. https://steviegjerky.com/ This jerky is DA BOMB! Tell them the Nice Guys sent you and maybe they'll send some more free samples. Nice Sponsors:Want to invest in the Nice Guys Podcast? Own your own little piece of it here- https://niceguysonbusiness.com/Invest You really need to check out Doug and Strickland's mastermind class on How to make money, grow your tribe, and build influence through podcasting. Check it out at www.turnkeypodcast.com/podcast Get your free E-Book 5 Ways to Make Money Podcasting at www.Turnkeypodcast.com/gift If you want to listen to a real podcast where you might actually learn something, check out Jared's "Up Your Average" podcast here- https://podcasts.apple.com/us/podcast/up-your-average-in-business-and-life/id1527032988 Simplecast is the easiest way to set up your podcast hosting- Simplecast.com Zoom is the easiest way to schedule meetings and record your podcast interviews-Zoom.us Acuity is the easiest way to schedule your podcast interviews, meetings, and life.Acuityscheduling.com See how The Nice Guys want to make your life easier? You can thank us later. Reach The Nice Guys Here: Doug- @DJDoug Strickland- @NiceGuyonBiz Nice Important Links: Subscribe to the Podcast website: Niceguysonbusiness.com Book Doug and/or Strick as a speaker at your upcoming event. Doug's Amazon #1 Best selling book Nice Guys Finish First. Partner Links: Amazon.com: Click before buying anything. Help support the podcast. Acuity Scheduling: Stop wasting time going back and forth scheduling appointmentsSimply the best VO guy in the business- https://steveobrienvo.com/ TurnKey Podcast Productions Important Links:The Ultimate Podcast Launch Formula www.turnkeypodcast.com/ultimatelaunchformula FREE workshop on how to "Be A Great Guest."Free E-Book 5 Ways to Make Money Podcasting at www.Turnkeypodcast.com/gift No time to get to this, but you can read the blog here: 12 worries that every entrepreneur has Audio production by Turnkey Podcast Productions. You're the expert. Your podcast will prove it.

In Podje Golf 59 zijn Guido Loning en Floris de Vries te gast. Ze hebben zelf ook succes gekend op de golfbaan, maar zijn nu allebei jeugdcoach bij de NGF en geven les op het Rijk van Nijmegen en de Sallandsche. Naast hun mening over het Nederlandse topgolf en talent geven ze ook waardevolle tips voor de luisteraars. Wat is de beste golftip die ze zelf ooit hebben gekregen? Waarom is golf zo moeilijk en welke slag moet je beheersen om gegarandeerd een lagere handicap te halen? Er zijn ook weer drie golfballen te winnen in de prijsvraag. Luister nu Podje Golf 59!

Faaaaaaaala Nerds, Geeks e Freaks!!!!!Chegou mais um NGFCast Live! Das nossas Lives do Youtube, no Canal NGF Sem Limites, mais um podcast direto do Pólo Norte!Vamos comemorar o Natal em Grande Estilo com a presença do Papai Noel e do Grinch no mesmo episódio ( espero que não dê briga )O Nerd mais perdido do Mundo e Adriano Holmes o Indio Nerd do Norte recebem Vanessinha e Ve Madero ( Ansiedade Nerd ), Renan ( RXW ) e Nilson Gomes ( Vida de Gado ) pra acompanhar o Papai Noel da NGF lendo as Cartinhas dos Ouvintes! E com o Grinch avacalhando ainda por cima!Pegue seu panetone, rabanada e venha ver o Papai Noel tendo que tirar da sacola desde playstation 5 a palmadas no bumbum! tudo isso regado a muito arroz com passas e Tênis do Jordam no nosso ja tradicional ESPECIAL DE NATAL!E Feliz Natal e Próspero Ano Novo a TODOS

The Nigerian Financial Intelligence Unit says that its ban on cash withdrawals for all federal and state accounts is to help governors and not to fight them. The NGF also set up a six-member committee to engage the Central Bank of Nigeria in addressing anomalies in the country's monetary management and financial system”. The NFIU says that the entire financial system suffered excess liquidity and liquidity ratio infringements which put hedging pressure on demand for foreign currency and gradually destroyed the value of the Naira and above all created wide room for money laundering and terrorism affecting significantly the rural populace on top of general inflation in the open market place.This show is part of the Spreaker Prime Network, if you are interested in advertising on this podcast, contact us at https://www.spreaker.com/show/4090160/advertisement

In this VETgirl online veterinary CE podcast, we interview Dr. Kristin Kirkby Shaw, DVM, MS, PhD, CCRT, DACVS, DACVSMR on diagnosing and treatment osteoarthritis (OA) in dogs. What are some challenges in diagnosing OA in dogs, and how do we manage OA in dogs? What role does the entire veterinary team play when managing dogs with OA? Learn about Nerve Growth Factor (NGF) and how it contributes to the pain associated with osteoarthritis. Also, learn how anti-NGF monoclonal antibodies work to control OA, so we can keep our canine patients comfortable.

Video: Commentary   Niall Ferguson – Woke Totalitarianism) (18:14) 13 stillborns in one hospital in 24 hours (1:54) Nurse blows whistle: C19 Shots and Spike in Baby issues; Refuses to inject poison. (1:30)   Asthma Can Be Reduced By Increasing Vitamin D Levels And Consuming Ginger Tel Aviv University (Israel) & Columbia University, November 13, 2022 According to research published in the journal Allergy, Dr Ronit Confino-Cohen and colleagues at Tel Aviv University analysed data from more than four million Israeli's that are members of the nation's largest healthcare provider — finding that of the 21,000 with asthma, those with a vitamin D deficiency were 25% more likely than other asthmatics to have had at least one flare-up in the recent past.

The effect of the vitamin is strongest in people with asthma and other lung diseases who are predisposed to respiratory infections. People with the worst vitamin D deficiency were 36 percent more likely to suffer respiratory infections than those with sufficient levels, according to research in Archives of Internal Medicine. “Vitamin D has significant immunomodulatory effects and, as such, was believed to have an effect on asthma — an immunologically mediated disease,” said Confino-Cohen. “But most of the existing data regarding vitamin D and asthma came from the pediatric population and was inconsistent. Our present study is unique because the study population of young adults is very large and ‘uncontaminated' by other diseases.” Professor Catherine Hawrylowicz from King's College London explained that findings already suggest that supplementation with vitamin D may one day be used not only to treat people who don't respond to medications but also to reduce the doses of dangerous steroids in other asthma patients – thus reducing the risk of harmful side effects. Of the 21,000 asthmatics studied, the team reported that those with vitamin D deficiency were at a higher risk of an asthma attack. Meanwhile, a team of US-based researchers have suggested that ginger compounds could also be effective in reducing the symptoms of asthma. The study, led by Elizabeth Townsend from Columbia University, investigated whether purified extracts of ginger that contained specific components of the spicy root could help enhance the relaxing effects of bronchodilators in asthmatic people. The research team explained that they studied the effects of three separate components of ginger: 6-gingerol, 8-gingerol or 6-shogaol when exposed to airway smooth muscle (ASM) tissue samples that were caused to contract by exposing them to acetylcholine. “We demonstrated that purified components of ginger can work synergistically with Beta-agonists to relax ASM,” said Townsend – adding that tissues treated with the combination of purified ginger components and isoproterenol showed significantly greater relaxation than those treated only with isoprotereno. Indeed, one of the three ginger components, 6-shogaol appeared most effective in increasing the relaxing effects of the Beta-agonist. (NEXT) Natural matcha green tea extract found to effectively kill breast cancer cells University of Salford (UK), November 05, 2022 A recent study carried out by the University of Salford has found that one kind of green tea in particular, matcha, can kill breast cancer cells effectively. The scientists at the university's Biomedical Research Center used a process known as metabolism phenotyping on breast cancer stem cell lines. They discovered that matcha “shifted cancer cells towards a quiescent metabolic state” while stopping them from spreading. Best of all, this was achieved using a rather low concentration of just 0.2 mg/mL. In addition, they discovered evidence that matcha affects the signaling pathways that promote cancer stem cells in a way that may make it a viable alternative to chemical cancer drugs like rapamycin. The scientist explained that the tea essentially suppresses oxidative mitochondral metabolism, preventing these cells from refueling. This causes them to become inactive and eventually die. University of Salford Professor of Translational Medicine Michael Lisanti said: “Our results are consistent with the idea that Matcha may have significant therapeutic potential, mediating the metabolic reprogramming of cancer cells.” (NEXT) Inflammation in midlife linked to brain shrinkage later Johns Hopkins University School of Medicine, November 11, 2022 People who show signs of inflammation in middle age are more likely to suffer from brain shrinkage later in life, a possible precursor to dementia or Alzheimer's disease, researchers said Wednesday. The findings in the journal Neurology are the latest to uncover an association between dementia and inflammation, in which the body's immune cells rev up in response to harms like smoking, stress, illness or poor diet. However, the findings stopped short of proving any cause-and-effect relationship. “These results suggest that inflammation in mid-life may be an early contributor to the brain changes that are associated with Alzheimer's disease and other forms of dementia,” said study author Keenan Walker of the Johns Hopkins University School of Medicine. “Because the processes that lead to brain cell loss begin decades before people start showing any symptoms, it is vital that we figure out how these processes that happen in middle age affect people many years later.” The study was based on 1,633 people with an average age of 53. Researchers tested their blood for levels of five markers of inflammation—not in any specific part of the body but rather throughout it—including the white blood cell count. An average of 24 years later, participants took a memory test and underwent brain scans. Those who had higher levels of inflammation at midlife on three or more biomarkers had an average five percent lower brain volume in the hippocampus and other areas associated with Alzheimer's disease, said the report. The effect was similar to having one copy of a gene—called apolipoprotein E (APOE) e4—that predisposes people to Alzheimer's, researchers said. People with higher inflammation also performed slightly worse on a memory test, remembering on average five of 10 words they were asked to recall, compared to 5.5 in the non-inflammation group. Outside experts described the study as large and rigorously conducted, but stressed that it did not study whether patients went on to develop Alzheimer's disease, only that some showed signs of brain shrinkage and memory loss. “This research points to inflammation as a potential early indicator of later brain degeneration, but we cannot say whether inflammation could be causing brain shrinkage or if it is a response to other damaging processes that might already be underway,” said Carol Routledge, director of Research at Alzheimer's Research UK. (NEXT) Adult ADHD has become epidemic—experts explain why University of California at Berkeley, November 7, 2022 Attention-deficit/hyperactivity disorder is growing up. Stephen Hinshaw and Katherine Ellison authors of ADHD: What Everyone Needs to Know, confirm that adults—and particularly women—are reporting to clinics in record numbers, becoming the fastest-growing part of the population receiving diagnoses and prescriptions for stimulant medications. “ADHD was never just for kids, and today many adults are getting the help they've needed for years,” says Hinshaw, a professor at the University of California at Berkeley and a respected global expert on ADHD. Ellison, a Pultizer-prize winning journalist, notes, “At least half of all children diagnosed with ADHD will continue to be impaired by their symptoms as adults, suggesting that approximately 10 million U.S. adults qualify for the diagnosis. Adult ADHD can lead to suffering through commonly accompanying disorders such as anxiety, depression, substance abuse, antisocial behavior, and gambling or Internet addictions. Social ties may well be frayed, with high risk of difficulties in intimate relationships. And, people with ADHD are also more likely to have a bitter history of academic and professional failures.” Indeed, researchers have found that adults who have been diagnosed with ADHD are up to 14 percent less likely than their peers to have a job. On average they also earn 33 percent less compared with people in similar lines of work and are 15 percent more likely to be receiving some form of government aid. The bottom line is that adult ADHD is not only real but has potentially devastating consequences, the experts agree. Hinshaw and Ellison also reveal a recent rapid rise in adult prescriptions for ADHD medication. One of the biggest surprises is that women of child-bearing age have become the fastest-growing group of consumers of ADHD medications. The number of annual prescriptions of generic and brand-name forms of Adderall surged among women over 26 years old, from a total of roughly 800,000 to some 5.4 million. (NEXT) Study shows clear new evidence for mind-body connection University of Calgary Department of Oncology, November 3, 2022 Impact of meditation, support groups seen at cellular level in breast cancer survivors For the first time, researchers have shown that practising mindfulness meditation or being involved in a support group has a positive physical impact at the cellular level in breast cancer survivors. A group working out of Alberta Health Services' Tom Baker Cancer Centre and the University of Calgary Department of Oncology has demonstrated that telomeres – protein complexes at the end of chromosomes – maintain their length in breast cancer survivors who practise meditation or are involved in support groups, while they shorten in a comparison group without any intervention. “We already know that psychosocial interventions like mindfulness meditation will help you feel better mentally, but now for the first time we have evidence that they can also influence key aspects of your biology,” says Dr. Linda E. Carlson, PhD, principal investigator and director of research in the Psychosocial Resources Department at the Tom Baker Cancer Centre. “It was surprising that we could see any difference in telomere length at all over the three-month period studied,” says Dr. Carlson, who is also a U of C professor in the Faculty of Arts and the Cumming School of Medicine, and a member of the Southern Alberta Cancer Institute. “Further research is needed to better quantify these potential health benefits, but this is an exciting discovery that provides encouraging news.” The study was published online in the journal Cancer. A total of 88 breast cancer survivors who had completed their treatments for at least three months were involved for the duration of the study. The average age was 55 and most participants had ended treatment two years prior. To be eligible, they also had to be experiencing significant levels of emotional distress. In the Mindfulness-Based Cancer Recovery group, participants attended eight weekly, 90-minute group sessions that provided instruction on mindfulness meditation and gentle Hatha yoga, with the goal of cultivating non-judgmental awareness of the present moment. Participants were also asked to practise meditation and yoga at home for 45 minutes daily. In the Supportive Expressive Therapy group, participants met for 90 minutes weekly for 12 weeks and were encouraged to talk openly about their concerns and their feelings. The objectives were to build mutual support and to guide women in expressing a wide range of both difficult and positive emotions, rather than suppressing or repressing them. The participants randomly placed in the control group attended one, six-hour stress management seminar. All study participants had their blood analysed and telomere length measured before and after the interventions. Scientists have shown a short-term effect of these interventions on telomere length compared to a control group, but it's not known if the effects are lasting. Dr. Carlson says another avenue for further research is to see if the psychosocial interventions have a positive impact beyond the three months of the study period. (NEXT) Lion's Mane Mushroom for Your Brain and Neuronal Health Green Med Info, November 8th 2022 Lion's mane mushrooms (Hericium erinaceus), with their shaggy, mane-like spines, stand out among fungi not only for their appearance but for their mild, sweet, seafood-like flavor. Like other mushrooms, lion's mane are multi-faceted healers, with antimicrobial, antihypertensive, antidiabetic and wound healing properties among their many therapeutic properties. Of the 68 diseases and conditions that lion's mane mushroom may support, many of them relate to the nervous system, including cognitive function, memory, dementia, depression, anxiety and sleep disorders. Lion's mane mushroom contains more than 35 beneficial polysaccharides that may help prevent or treat cancer, gastric ulcers, diabetes, hyperlipidemia, liver injury and neurodegenerative diseases, according to a review published in the International Journal of Biological Macromolecules. With a long history of use in Traditional Chinese Medicine, including for brain and neurological health, it's now known that two terpenoid compounds– hericenones and erinacines — in these mushrooms and their mycelia may stimulate the synthesis of nerve growth factor (NGF). Active compounds in lion's mane mushrooms may also delay neuronal death in neurodegenerative diseases, including ischemic stroke, Parkinson's disease, Alzheimer's disease and depression, while promoting nerve regeneration in cases of neuropathic pain or age-related hearing loss (presbycusis). Some of their top therapeutic benefits include: Regenerate Damaged Nerves – Lion's mane has been shown to trigger neurite outgrowth in brain, spinal cord and retinal cells. It also stimulates the activity of nerve growth factor, which is important for the growth and differentiation of neurons. Boost Cognitive Function – In adults with mild cognitive impairment , those who took lion's mane powder three times a day for 16 weeks significantly increased their scores on a cognitive function scale compared with those who took a placebo. Hericenones in lion's mane are believed to be responsible for some of the mushroom's beneficial effects on brain neural networks and improvements to cognitive function. This brain-boosting mushroom has also been found to improve memory in mice.[xi] Fight Depression – Lion's mane may ameliorate depressive disorder through a variety of mechanisms, including neurogenic/neurotrophic and anti-inflammatory pathways. Animal studies suggest that lion's mane may reverse depressive behaviors caused by stress by modulating monoamine neurotransmitters and regulating BDNF pathways. Support for Neurodegenerative Disease – neurotrophic compounds are known to pass through the blood-brain barrier and have been used to treat cognitive impairments, Alzheimer's disease and Parkinson's disease. In a study of patients with mild Alzheimer's disease, those who took lion's mane mycelia capsules for 49 weeks had improvements in their ability to carry out daily activities, such as personal hygiene and preparing food. Improve Mood and Sleep Disorders – Among overweight or obese people with sleep disorders or mood disorders, lion's mane was effective in relieving symptoms. Eight weeks of lion's mane supplementation decreased depression, anxiety and sleep disorders in the study, while also improving mood disorders of a “depressive-anxious nature” and boosting the quality of sleep at night.

VIDEOS: Hang on, the WEF is now doing THIS to our internet? | Redacted with Clayton Morris – 7:00 This intense AI anger is exactly what experts warned of, w Elon Musk. – 15:01 New Brain Implant Begins Human Trials – Neuralink Update! – 14:00  Get the latest information from the CDC about COVID-19. Professor Sucharit Bhakdi, M.D – 10:00  Study links omega-3s to improved brain structure, cognition at midlife University of Texas Health Science Center, October 5, 2022 Eating cold-water fish and other sources of omega-3 fatty acids may preserve brain health and enhance cognition in middle age, new evidence indicates. Having at least some omega-3s in red blood cells was associated with better brain structure and cognitive function among healthy study volunteers in their 40s and 50s, according to research published in Neurology®, the medical journal of the American Academy of Neurology. “Studies have looked at this association in older populations. The new contribution here is that, even at younger ages, if you have a diet that includes some omega-3 fatty acids, you are already protecting your brain for most of the indicators of brain aging that we see at middle age,” said Claudia Satizabal, PhD the lead author of the study. Volunteers' average age was 46. The team looked at the relation of red blood cell omega-3 fatty acid concentrations with MRI and cognitive markers of brain aging. Researchers also studied the effect of omega-3 red blood cell concentrations in volunteers who carried APOE4, a genetic variation linked to higher risk of Alzheimer's disease. The study of 2,183 dementia- and stroke-free participants found that: Higher omega-3 index was associated with larger hippocampal volumes. The hippocampus, a structure in the brain, plays a major role in learning and memory. Consuming more omega-3s was associated with better abstract reasoning, or the ability to understand complex concepts using logical thinking. APOE4 carriers with a higher omega-3 index had less small-vessel disease. The APOE4 gene is associated with cardiovascular disease and vascular dementia. “Omega-3 fatty acids such as EPA and DHA are key micronutrients that enhance and protect the brain,” said study coauthor Debora Melo van Lent, PhD, postdoctoral research fellow at the Biggs Institute. “Our study is one of the first to observe this effect in a younger population. More studies in this age group are needed.” Multiple health benefits of b-type procyanidin-rich foods like chocolate and apples consumed in right amounts Shibaura Institute of Technology (Japan), October 5, 2022 B-type procyanidins, made of catechin oligomers, are a class of polyphenols found abundantly in foods like cocoa, apples, grape seeds, and red wine. Several studies have established the benefits of these micronutrients in reducing the risk of cardiovascular diseases and strokes. B-type procyanidins are also successful in controlling hypertension, dyslipidemia, and glucose intolerance. Studies attest to the physiological benefits of their intake on the central nervous system (CNS), namely an improvement in cognitive functions. These physiological changes follow a pattern of hormesis—a phenomenon in which peak benefits of a substance are achieved at mid-range doses, becoming progressively lesser at lower and higher doses. Researchers from Shibaura Institute of Technology (SIT), Japan, led by Professor Naomi Osakabe, reviewed the data from intervention trials supporting hormetic responses of B-type procyanidin ingestion. The team conducted in vivo experiments to understand possible connections between B-type procyanidin hormetic responses and CNS neurotransmitter receptor activation. Their article has been published in Frontiers of Nutrition . The researchers noted that a single oral administration of an optimal dose of cocoa flavanol temporarily increased the blood pressure and heart rate in rats. But the hemodynamics did not change when the dose was increased or decreased. Administration of B-type procyanidin monomer and various oligomers produced similar results. According to Professor Osakabe, “These results are consistent with those of intervention studies following a single intake of food rich in B-type procyanidin, and support the U-shaped dose-response theory, or hormesis, of polyphenols.” To observe whether the sympathetic nervous system (SNS) is involved in the hemodynamic changes induced by B-type procyanidins, the team administered adrenaline blockers in test rats. This successfully decreased the temporary increase in heart rate induced by the optimal dose of cocoa flavanol. A different kind of blocker—a1 blocker—inhibited the transient rise in blood pressure. This suggested that the SNS, which controls the action of adrenaline blockers, is responsible for the hemodynamic and metabolic changes induced by a single oral dose of B-type procyanidin. The researchers next ascertained why optimal doses, and not high doses, are responsible for the thermogenic and metabolic responses. They co-administered a high dose of cocoa flavanol and yohimbine (an α2 blocker) and noted a temporary but distinct increase in blood pressure in test animals. Similar observations were made with the use of B-type procyanidin oligomer and yohimbine. Professor Osakabe surmises, “Since α2 blockers are associated with the down-regulation of the SNS, the reduced metabolic and thermogenic outputs at a high dose of B-type procyanidins seen in our study may have induced α2 auto-receptor activation. Thus, SNS deactivation may be induced by a high dose of B-type procyanidins.” Meditation keeps emotional brain in check Michigan State University, September 29, 2022 Meditation can help tame your emotions even if you're not a mindful person, suggests a new study from Michigan State University. Reporting in the journal Frontiers in Human Neuroscience, psychology researchers recorded the brain activity of people looking at disturbing pictures immediately after meditating for the first time. These participants were able to tame their negative emotions just as well as participants who were naturally mindful. “Our findings not only demonstrate that meditation improves emotional health, but that people can acquire these benefits regardless of their ‘natural' ability to be mindful,” said Yanli Lin, an MSU graduate student and lead investigator of the study. “It just takes some practice.” Researchers assessed 68 participants for mindfulness using a scientifically validated survey. The participants were then randomly assigned to engage in an 18-minute audio guided meditation or listen to a control presentation of how to learn a new language, before viewing negative pictures (such as a bloody corpse) while their brain activity was recorded. The participants who meditated – they had varying levels of natural mindfulness – showed similar levels of “emotion regulatory” brain activity as people with high levels of natural mindfulness. In other words their emotional brains recovered quickly after viewing the troubling photos, essentially keeping their negative emotions in check. In addition, some of the participants were instructed to look at the gruesome photos “mindfully” (be in a mindful state of mind) while others received no such instruction. Interestingly, the people who viewed the photos “mindfully” showed no better ability to keep their negative emotions in check. This suggests that for non-meditators, the emotional benefits of mindfulness might be better achieved through meditation, rather than “forcing it” as a state of mind, said Moser, MSU associate professor of clinical psychology and co-author of the study. A mother's ultra-processed food intake may be linked to obesity risk in her children Massachusetts General Hospital and Harvard Medical School, October 5, 2022 A mother's consumption of ultra-processed foods appears to be linked to an increased risk of overweight or obesity in her offspring, irrespective of other lifestyle risk factors, suggests a U.S. study published by The BMJ today. The researchers that mothers might benefit from limiting their intake of ultra-processed foods, that dietary guidelines should be refined, and financial and social barriers removed to improve nutrition for women of childbearing age and reduce childhood obesity. Researchers drew on data for 19,958 children born to 14,553 mothers (45% boys, aged 7-17 years at study enrollment) from the Nurses' Health Study II (NHS II) and the Growing Up Today Study (GUTS I and II) in the United States. The results show that a mother's ultra-processed food consumption was associated with an increased risk of overweight or obesity in her offspring. For example, a 26% higher risk was seen in the group with the highest maternal ultra-processed food consumption (12.1 servings/day) versus the lowest consumption group (3.4 servings/day). Reishi Mushrooms Proven For Fibromyalgia Pain Relief In Human Study University of Extremadura (Spain), September 29, 2022 A promising double-blind, randomized human clinical study of ganoderma lucidum, also known as reishi mushroom, has been shown to be effective in treating fibromyalgia chronic pain. To begin, science knows that the reishi mushroom is the most studied nutraceutical and that it has been used safely and effectively for thousands of years. It is often called the mushroom of longevity and immortality. Reishi has several biologically-active compounds in it, including triterpenes, which have been shown to increase the production of Nerve Growth Factor. NGF is a protein that helps to create new neurons and repair damaged neurons. This also enhances the communication between cells and reduces inflammation. In the fibromyalgia chronic pain study, one group consumed 6 grams of reishi mushroom powder per day and another group consumed 6 grams of carob powder per day. Each group participated for 6 weeks and continued to self-report their experiences for 72 days after the treatment. The reishi mushroom group experienced pain reduction by up to 30%, which is significant. They also reported getting better sleep, were happier and gained aerobic endurance and body flexibility. Time-restricted eating improves health of firefighters Salk Institute, October 3, 2022 In collaboration with the San Diego Fire-Rescue Department, scientists from the Salk Institute and UC San Diego Health conducted a clinical trial and found that time-restricted eating improved measures of health and well-being in firefighters. The lifestyle intervention only required the firefighters to eat during a 10-hour window and did not involve skipping meals. The new findings, published in Cell Metabolism may also have implications for shift workers, such as military personnel; health care, food service, and transportation professionals; telecommunications staff; and new parents, whose schedules often mimic shift work when caring for a new baby. “Doctors and researchers are always thinking about the magic pill that can cure or reduce disease. Our study showed that shift workers with high blood pressure, blood sugar, or cholesterol can benefit from a simple lifestyle intervention called time-restricted eating,” says Salk Professor Satchidananda Panda, co-corresponding author of the study and holder of the Rita and Richard Atkinson Chair. Almost every cell in the body has a 24-hour biological clock that produces circadian (daily) rhythms. These rhythms regulate behavior (e.g., when to be active and when to rest) and physiology (e.g., blood pressure, blood sugar, muscle function). Circadian rhythms coordinate with the environment in part by regular, timed cycles of light and dark and eating and fasting. Disruptions to these cycles, which can occur with shift work, can impact health, leading to obesity, heart disease, diabetes, and cancer. In this clinical trial, 150 firefighters from the San Diego Fire-Rescue Department used the myCircadianClock app on their phones to track their eating for three months. Half the group ate within a 10-hour window, while the other half (the control group) changed nothing and ate within a 14-hour window. Both groups were encouraged to follow a Mediterranean diet, which is known to have health benefits. The study included both individuals who were healthy and those who were overweight or who had health conditions such as high blood pressure, cholesterol, and/or blood glucose. The researchers found that time-restricted eating within a 10-hour eating window was feasible without adverse effects and helped the firefighters significantly decrease their VLDL (“bad”) cholesterol size by 1.34 nanometers (small VLDL is less likely to block arteries), improve their mental health, and reduce their alcohol intake by roughly three drinks per week. Time-restricted eating also significantly improved blood sugar and blood pressure in firefighters who had elevated levels at the start of the study. The researchers concluded that time-restricted eating may provide even greater benefit for those at risk for cardiometabolic disease and other chronic diseases.

Aldri før har flere spilt golf i Norge enn akkurat nå. Men etter den store koronafesten kommer nå en like stor test: Hvordan skal vi klare å beholde alle sammen – og vokse videre? Generalsekretær Tor-Anders Hanssen i NGF ser både løsninger og utfordringer for Golf-Norge framover. 

Listen in as Jay Karen (NGCOA CEO) and Don Rea, PGA (Secretary, PGA of America) chat with Joe Beditz, President & CEO of the National Golf Foundation. What are the industry trends surging to the top of NGF's radar – and how will they affect your golf operations? Joe, Jay and Don discuss the unprecedented levels of new participation and how course owners can improve the customer experience and increase golfer retention.   Then, Golf Business LIVE host Michael Williams welcomes 100GROUP's Jeff Brodsly (CEO) and Trevor Bastien (Director of Sales) for this edition of House Chat. Discover how they're changing the game for course owners when it comes to credit card processing. Hear how members are running a more efficient, secure, and cost-saving operation courtesy of 100GROUP, one of the latest NGCOA Smart Buy Partners.

What is learning and memory? Is amnesia really a loss of stored memories or something more? In this interview, we will discuss where memory goes and if there is a way to retrieve them after trauma. Recent studies have shown that spatial memories are encoded as sparse populations of cells that are activated during learning and are necessary for the retrieval of specific memories. We refer to these cells as "memory engram cells" and the focus of Tomás J Ryan and his team is to understand how engram cells are able to store specific memories as information. Here is a quick summary/breakdown of the video above. The old storage theory of amnesia is WRONG. The problem is the ability to retrieve the memory. Short term memory lasts a few hours. It is very disruptable (long term is not). Long term memory lasts your entire lifetime. It requires transcription and translation of many different genes. We have many different genes that regulate memory. They are different for short term and long term - playing roles at different stages. Most popular was CREB (turns on other genes). Engrams cells are structures in the brain where memories are stored. R They used optigenetics to prove engram cells were important for memory. Engram cells only account for 4-6% of the brain cells in the hippocampus (of mice). V Consolidation idea - a short term memory (unstable) forms into a long term memory (stable), thus stabilizing the engram. Optogenetics - let's us express photoactivatable opsins in whatever region of the brain we want. The brain is electrically active. They put certain opsins into brain cells and then stimulate them with light. These opsins can conduct ions - putting positively charged cations from the external environment of the cell into the neuron. This depolarizes the cell, which results in an action potential (creating neuronal activity). What they did at MIT was integrate optogenetics and memory engram cells. They tested parts of the brain using a transgenetics - they took immediate/early genes (genes that show activity as a function of neuronal spike) and used opsins to only activate those genes. Amnesia and Memory Learning is the enhancement of synaptic connections. Memory is a stable thing in the brain and can last for your entire life. Learning and recall are not "things", they are activities. Learning = process of making a memory. Recall = process of retrieving a memory. So the problem is not memory itself. Amnesic engram cells have a loss of synaptic strength. Increasing the synaptic strength helps get the memory (which is commonly seen in Alzheimer's (AD), Huntington's (HD)). If you increase the synaptic potentiation (increasing the dendritic spine density), esp. of the amnesic engram cells, you can get natural access to those memories. Neurotrophic factors (BDNF, NGF, CNTF, GDNF) do this, but are not localized nor memory specific. Learning something new (about something you are amnesic about) will train your brain to those particular engram cells. Once you activate the engram cells (with optogenetics), you can restore access to old information and add new information on those amnesic memories. Without dealing with the cause, you probably won't be able to really restore memories (in diseases like AD, HD, etc.) In late stages of neurodegeneration, you may actually lose memories. Actions to take for prevention Stay mentally active Engage in physical exercise Actions to take for amnesia (acute memory loss) Do everything to remind yourself of those experiences Retrain on the "forgotten" pieces We briefly discussed gene expression and histone acetylation to enhance memory. https://mybiohack.com/blog/tomas-j-ryan-debunking-amnesia-and-stabilizing-engram-cells

In this podcast, we will discuss nootropics, anti-aging, and healing/enhancement peptides. https://mybiohack.com/blog/cerebrolysin-epitalon-bpc157-ghkcu-lgd4033-ostarine-mk-677 If you can get a prescription from a doctor, then use Tailor Made Compounding for high quality peptides. If you can't then using other high quality sources are also available: Cerebrolysin - combination of BDNF, NGF, GDNF, and CNTF Epitalon - longevity BPC-157 - gut health/neurotransmitter balance GHK-cu - skin health/wound healing Ligandrol (LGD-4033) - prevents muscle wasting Ostarine (MK-2866) - muscle mass Ibutamoren (MK-677) - long acting ghrelin mimetic

Ok! Podcast breakdown follows: Intro – specials on Nootropic products Breakdown on Noopept Noopept dose range compared to Piracetam BDNF and NGF properties of Noopept Effects (anecdotal) of Noopept across nootropics users The “Cholinosensitizing” effect of Noopept (its effect on acetylcholine signaling in the brain) Cycling Noopept   Ok! Podcast breakdown follows: Intro – specials […] The post Ep 82: The cholinergic properties of Noopept REVEALED first appeared on .