Podcasts about Swanton

Let us know what you think - text the show!On this week's show:Happy National No Pants DayMobile home rules are pissing off seniorsVermont Construction Academy celebrates official launchMajority of Bradford firefighters resign in protest of chief's demotionNo Fairlee drive-in this summerEnosburgh PDWoodstock Police Chief Is Demoted to Patrol Officer Department of Duh: minorities pulled over more often in VTEssex Junction looking for a rebrand(48:35) Break music:  like bunny - Last Kidshttps://likebunny.bandcamp.com/track/last-kids Isle LaMotte man wants to keep old national guard towerHow green is Vermont's cannabis industry?Final Reading: Regulators prepare to roll out medical cannabis sales at VerScrappy Burlington High School Debaters Make National Finals | Seven DaA look at plans to transform former Vermont school into spaSearch teams find body of missing hiker during trainingCrews rescue person stranded on island in Winooski River(1:20:30) Break music:  Burly Girlies - $1.25https://burlygirlies.bandcamp.com/track/125 Scumbag mapInvoluntary manslaughter in BarreHow a high-profile Vermont murder case fell apart - VTDiggerNorwich University students arrested for theft at Caledonia County cannabis farm Cavendish man charged with arson Whatchu know about Cavendish, VT? Williamstown, VT man steals truck on camSuspect arrested in Burlington shooting that injured  + 2nd suspect arrestedVt. teacher accused of driving to school drunkFormer Newport substance abuse counselor sentenced following multiple viThanks for listening!Follow us on Facebook: facebook.com/VermontCatchup Follow Matt on twitter: @MatthewBorden4 Contact the show: 24theroadshow@gmail.comOutro Music by B-Complex

The TNI-UK team of LimpstarUK & The Joeker review TNA Rebellion & look into other major talking points of the last week. Featuring: - Indi Hartwell signs with TNA Wrestling! - Shane Haste walks with Elijah! - Leon Slater goes viral after an insane Swanton 450 during #UltimateX! - The Hardys are dethroned by The Nemeths! - Sean Waltman (X-Pac) returns to TNA to help Ace Austin & The Rascalz beat The System! - Trick Williams attacks Joe Hendry after his match, Shawn Michaels responds. Review - Countdown To Rebellion - Fatal Influence (Fallon Henley, Jacy Jayne & Jazmyn Nyx) vs. Xia Brookside, Léi Yǐng Lee & Rosemary - Shane Haste vs. Elijah Rebellion (Pay-Per View) - Ultimate X (X-Division Championship) Moose vs. Leon Slater, Matt Cardona, El Hijo del Vikingo, KC Navarro & Sidney Akeem - 4-Way Tag Team (Knockouts World Tag Team Championship) Ash & Heather By Elegance vs. Lash Legend & Jakara Jackson, Spitfire & Gigi Dolin & Tatum Paxley. - 6-Man Tag Team Match Ace Austin & The Rascalz (Trey Miguel & Zachary Wentz) w/ Sean Waltman vs. The System (Moose, Eddie Edwards & Brian Myers) w/ Alisha Edwards - (TNA International Championship) Steve Maclin vs. Eric Young - Mike Santana vs. Mustafa - (Knockouts World Championship) Masha Slamovich vs. Tessa Blanchard - (TNA World Tag Team Championship) The Nemeths vs. The Hardys - (TNA World Championship) Joe Hendry vs. Ethan Page & Frankie Kazarian All of this plus a look into the news and rumours surrounding TNA Wrestling, this week's Xplosion as well as a look towards this week's episode of TNA iMPACT WRESTLING! Chris Bey Go Fund Me: https://www.gofundme.com/f/chris-bey-recovery-funds #WeLoveBey CONNECT WITH TOTAL NONSTOP IMPACT: Social Media: Twitter - https://www.twitter.com/WETALKIMPACT Twitch - https://www.twitch.tv/TotalNonstopIMPACT Instagram - https://www.instagram.com/WETALKIMPACT Facebook - https://www.facebook.com/WETALKIMPACT TNI-UK Bison's Twitter - https://twitter.com/LordBison45 JoeKer's Twitter - https://twitter.com/JOKEmptySpace Steve's Twitter - https://twitter.com/simplysteve311 Craig's Twitter - https://x.com/NetworkStooge Bison's TikTok - https://tiktok.com/@bisonbydesign Craig's TikTok - https://tiktok.com/@limpstaruk JoeKer's YouTube - https://youtube.com/channel/UCddtM170Glce-NagWJZgupw or search user @joekerwildeDBJ87 TNI-US Trent's Twitter - http://www.twitter.com/trentzuberi Jaybone's Twitter - http://www.twitter.com/jaybone5150 Kyle's Twitter - http://www.twitter.com/kl_tni Alicia's Twitter - http://www.twitter.com/aliciabcakey William's Twitter - https://twitter.com/williammgardner Marq's Twitter – None Streaming Audio: Apple iTunes - https://apple.co/2NpzbqF Stitcher Radio - https://bit.ly/2DjPznT Google Play - https://tinyurl.com/ybh29sfp TuneIn Radio - https://bit.ly/2NreA57 iHeart Radio: https://ihr.fm/laugeb Spotify: https://spoti.fi/2B1zBeL Soundcloud - https://soundcloud.com/user-625858195 Pandora - https://pandora.app.link/07JHdVjfc9 Twitch: twitch.tv/totalnonstopimpact Pro Wrestling Tees: www.prowrestlingtees.com/totalnonstopimpact Spreadshop Merchandise: Featuring Caps, Hoodies, Mugs, & MORE! total-nonstop-impact.myspreadshop.com Connect with us now on our Discord: https://discord.gg/WeRNdtC3ba Join our TNI-UK Facebook Group: https://www.facebook.com/groups/totalnonstopimpactuk #TNAonAXSTV #BTIonAXSTV #TNAWRESTLINGDAZN #TNAWRESTLING #TNAREVOLUTION #TOTALNONSTOPIMPACT #TNIUK #IMPACTED #WeAreIMPACTED #TNITRIBE #TNIArmy #NXT #WWE #NXTNA #TNAREBELLION #REBELLION

Let us know what you think - text the show!On this week's show:Happy National Hug a Plumber DayMeasles in VTBill passes to erase medical debtBootlickers raid a farm in Berkshire, VTWhatchu know 'bout Berkshire, VT?How's that rental registry working out?People buying chickBye Michael HarringtonBurlington South End housing project hits a barrier State employees union leader secretly filmedLawmakers look at proposed new alcohol tax(57:29) Break music:  EXIA ULTA - “Pamela Anderson Lee Calendar”https://exiaulta.bandcamp.com/track/pamela-anderson-lee-calendar  Our old friend, Myers Mermel and WDEV Northfield police chief criticized for attireThe Poultney Booster club is big mad Bradford teen center is blowing up90-year-old track star from Shelburne, VTNew life for Danville train stationBurlington considers scrapping recycling program(1:27:24) Break music:   Jas Stewart - Wasn't for the Moneyhttps://jasstewart.bandcamp.com/track/wasnt-for-the-money Scumbag mapBurlington knife attack Restaurant stabber convicted Walmart break-in Store in Barre robbed A sign of spring? Rutland's first shooting of the year Burlington man shoots into parked car Stocker the stalker A well-placed headbuttThanks for listening!Follow us on Facebook: facebook.com/VermontCatchup Follow Matt on twitter: @MatthewBorden4 Contact the show: 24theroadshow@gmail.comOutro Music by B-Complex

Let us know what you think - text the show!On this week's show:Happy International Amateur Radio DayZoie Saunders standing up to Trump for DEIAirport beefMiddlebury encampment policyGov. Phil Scott: 'The best interest' of detainees will guide decision on state aManchester says “no flags”Bernie at CoachellaNorth Hero school to close permanently in JuneBurlington Adopts Zoning to Encourage Higher Ground Move A Large Farm With Pollution Problems Wants to ExpandBurlington to offer free parking WednesdayJoe's pond - spring is here!(43:12) Break music:  Raptors - “Tiny Little Robots”https://raptorsarethebest.bandcamp.com/track/tiny-little-robots One District, One Book Reading programNo background checks at Rutland parks & RecVermont beekeepers work to produce future generations of disease-resistant  Putney Library looking for booksSmart-cribs soothe babies experiencing opiate withdrawalLamoille County Sheriff's deputy placed on leave over conversation with deFinal Reading: What does the Portuguese Olympic Committee have to do wit(1:18:10) Break music:   Amystera - “Rebirth”https://amystera.bandcamp.com/track/rebirth Scumbag map St J cop used excessive force in Barre Something fishy about this Plainfield crashPolice looking for Colchester shooting suspectBridport teen admits to killing fatherBurlington clothes heist Bring back catamounts? Levi, the crime-fighting bulldogThanks for listening!Follow us on Facebook: facebook.com/VermontCatchup Follow Matt on twitter: @MatthewBorden4 Contact the show: 24theroadshow@gmail.comOutro Music by B-Complex

WhatCulture's Andrew Pollard speaks to rising TNA star Leon Slater on TNA's connection with UK fans, growing up a TNA kid, his INSANE global schedule, innovating the Swanton 450, getting to work with his heroes the Hardys, facing Matt or Jeff, and more...ENJOY!Follow us on Twitter:@CulturedLeftPeg@WhatCultureWWE Hosted on Acast. See acast.com/privacy for more information.

Let us know what you think - text the show!On this week's show:Happy national Barbershop Quartet DayCVU students getting deported + Oh wait, maybe notCase of Turkish Tufts Student Arrested by ICE Will Be Heard in Vermont Pownal student who brought gun to school said he was bulliedMain Street construction hurting Burlington businessNew Burlington movie theater?State treasurer says tariffs could cost Vermont $1 billion a year; Local buSweeping Education Reform Bill Advances in Vermont House Incarcerated dads can get child visits(1:06:51) Break music:  Night Protocol - “Blood and Whiskey”https://nightprotocol.bandcamp.com/track/blood-and-whiskey-2  St J is getting a new sign and we can vote Planned Parenthood to Shutter St. Johnsbury Clinic  Whatchu know bout Saint J?VT needs fishing teachersFlushing hydrants in ColchesterFather & son police chiefsCabot Premium Butter recalled over possible fecal contamination(1:59:00) Break music:  Kozmic Jones - “Body”https://kozmicjones.bandcamp.com/track/5-body  Scumbag map Man charged with the attempted murder of former boss, the chef of Brandon's Café Young arsonists in BarreArmed Colchester man chased woman outside daycare Montpelier police log Lyndon dog thiefVermont battles beavers for dam compliance Frog-pocalypseThanks for listening!Follow us on Facebook: facebook.com/VermontCatchup Follow Matt on twitter: @MatthewBorden4 Contact the show: 24theroadshow@gmail.comOutro Music by B-Complex

In this episode of The Cancer Researcher Podcast we interview Professor Charlie Swanton, Deputy Clinical Director of the Francis Crick Institute and Chief Clinician at Cancer Research UK on his research interests, the evolution of the field and how he turned round his failing PhD. Charlie also shares with us what he's looking forward to at the EACR Congress ahead of his Keynote Lecture and gives some excellent advice to early-career researchers on how to break away from the shyness that could hold some back from asking questions and networking at conferences.

Let us know what you think - text the show!On this week's show:Happy national School Librarian DayYankees - innovators or big fat cheaters?Should church pay retiring child abusers?Road linking VT and Montreal scrappedVT goin' nuclearPotential changes to VT's little known panfish marketWelch wants local dairy farmers to get their milk in schoolsThe feds are usingVermont's prisons for immigration  Amtrak's Vermonter celebrates 30th anniversaryProgressive young  Vermonters are giving away inheritances(53:30) Break music:  Boomslang - “Together”https://boomslangvt.bandcamp.com/track/together  BETA goes coast to coast Burlington city council president challengeThe mad hatter of Manchester They're cutting the kids rocket programsVT family gets an empty urnLocal group expected to acquire Burke Mountain ski resortEat Vermont appVermont Brewer Donates Captured CO2 to Cannabis Grower SunCommon Sues Former Manager Who Defected to Competitor(1:38:57) Break music:  Ranjii - “Dear Lifehttps://rajnii.bandcamp.com/track/dear-life-2 Scumbag map Murder for hire plot foiledEast Ryegate shootoutHit and run / attempted homicide Rutland roofer tax evader Man arrested in Virgin Islands for threatening VT county prosecutor Plainfield dog scofflawSlow down for amphibians and salamanders Coyote attacks person in HinesburgThanks for listening!Follow us on Facebook: facebook.com/VermontCatchup Follow Matt on twitter: @MatthewBorden4 Contact the show: 24theroadshow@gmail.comOutro Music by B-Complex

Let us know what you think - text the show!On this week's show:Happy national Memory DayUhhh, what did we miss?Portugal recap?Amazon coming to EssexFewer regulations for at-home food makersProposed changes to Vermont's ‘right to farm' law make headway in the SeBen & Jerry's claims parent company fired CEO over brand's progressive acAs US-Canada relations sour, Vermont businesses are facing boycotts Canadian Ire Over Trump Hits Vermont's Distillers (52:02) Break music:  Brunch - Dr. Benway (Live at Robot Dog) https://brunchtheband.bandcamp.com/track/dr-benway-live-at-robot-dogShelburne Cop Who Hit and Killed Cyclist Pleads Not Guilty  Woodstock police chief in limboBuffalo pothole banditRutland gets a gay barSenate Votes to Confirm Zoie Saunders as Education Secretary Report details costly restoration work needed at Bennington Monument VT students win fish art contest(1:32:29) Break music:  MF Oblivion - From the Woodshttps://mfoblivion.bandcamp.com/track/from-the-woods-ft-dj-lucas-subjxct-5 Scumbag map School shooting avertedHung jury in thieving trooper trialPipe bomb found during Vermont traffic stop, police  Berlin thief? Hit and run driver identifiedBurlington kidnapping plotBears coming out of hibernationWorld happiness rankings 2025Thanks for listening!Follow us on Facebook: facebook.com/VermontCatchup Follow Matt on twitter: @MatthewBorden4 Contact the show: 24theroadshow@gmail.comOutro Music by B-Complex

It's our final Titans of Science offering of this series, with world-leading cancer expert Charlie Swanton. We'll hear how the latest developments in our understanding of cancer's mechanisms are shaping treatments and preventative measures... Like this podcast? Please help us by supporting the Naked Scientists

This New Fire Chiefs Roundtable episode is packed with information on what to expect if you are a new fire chief or inspiring to be a chief. Host - Clayton O'Brien - Fire Chief City of Oregon (cobrien@oregonohio.org) Co-Host - Josh Eberly - Fire Chief City of Findlay (jeberle@findlayohio.gov) Guest - Shawn Wittkop - Fire Chief City of Defiance (swittkop@cityofdefiance.com) Guest - David Bowen - Fire Chief City of Napoleon (dbowen@napoleonohio.com) Guest - Cuyler Kepling - Fire Chief City of Swanton (firechief@swantonfire.com)

Let us know what you think - text the show!On this week's show:Happy national Drinking Straw DayWe're number 4 - Vermont's homelessness ranks 4th in nationVT Truth and Reconciliation Committee needs 3rd memberFewer traffic deaths in 2024Increasing pharmacy closures mean long drives for Vermont residents, mirroring a ‘An anomaly?': Pay to state employees under investigation exceeds $2.6 million tMontpelier officials use treated wastewater to shrink Winooski River ice jam Year in Review: Brattleboro contends with a troubled downtown (1:02:27) Break music:  Jacob Green - “If the Spirit Moves You, Let It Shine”https://jacobgreen.bandcamp.com/track/if-the-spirit-moves-let-it-shine Westbury, VT's newest village, is one year oldSaint Mike's going free tuitionStowe native breaks world ski recordYoung VT ninja warriorsStewart's Shops completes purchase of Jolley stores Federal judge dimisses pro-Palestinian student group's lawsuit against UVM  Vermont's 2024 cannabis data released | GreenMountain Vermont Cannabis Departure of the Associated Press' last Vermont reporter marks the end of (1:38:52) Break music:  Michael Roberts - “2030”https://songsofmichaelroberts.bandcamp.com/album/rose-gold Scumbag mapVandalism closes University Mall; suspect arrestedStamford man accused of arson, insurance fraud Hannaford robbery in Saint Albans Barre dumpster fire Assault and Thanks for listening!Follow us on Facebook: facebook.com/VermontCatchup Follow Matt on twitter: @MatthewBorden4 Contact the show: 24theroadshow@gmail.comOutro Music by B-Complex

Get in touch with Ultrarunning Sam here ⬅️In this episode I speak to Laura Swanton Rouvelin, who is returning to this years Spine Race.Laura has had mixed success at the Spine over the years, from a DNF due to back pain, to returning only to have the same back issues, but gutting out the rest of the race to finish. She then came back in the summer of 2023 to land on the podium in 2nd place and 7th overall for Britains Most Brutal race.This time she takes on the winter race hoping to better her previous performances.We talk about her approach to training and how that's changed over the years under the watchful eye of her coach - Kim Collison. We talk about the steps she's taken to strengthen her back in preparation for carrying the infamous "Spine Pack"We talk a lot about how she juggles work, parenting, running and her favourite hobby, horse riding!We talk about everything that the Spine throws at you, from spectacular views, to destroyed feet and everything in between!This was a great chat and I'm really excited to see how she gets on next week!URS

Let us know what you think - text the show!Happy national Sangria DayIts easier to get to TampaMayor concerned about Burlington police staffing reportSaint Albans has its own policing problemsUVM men's soccer wins 2024 NCAA tournamentPro-Palestinian ballot measure fails to make it to bal Tenants vs landlords$21.8M housing project to create 40 units in Newport area Governor to again ask lawmakers to delay juvenile justice Burlington Cannabis Shop to ClosePutney Mountain Hawkwatch Recent Canada lynx sightings (1:01:46) Break music:  Bone Bone - “Jounce”https://burlingtonelectronicdepartment.bandcamp.com/track/jounce Will it lamp?Bethel's 1st annual drag ChristmasCollecting VermontianaManure spreading ban Barre emergency crews to get better radio coverageWCAX Investigates: Why didn't financial irregularities trigger state invBernie Look alike(1:28:27) Break music:  Cave Chimera - “Things Change”https://cavechimera.bandcamp.com/track/things-change Scumbag mapShaftsbury man faces years  of jail without trial after re-offendingAmbulance fracasVT man accused of serious mail threatsSoBu man connected with Saint J robberyBelvidere camp murderSaint Albans grocery store clerk assaulted The ol crash and grab in RutlandNewport woman charged with forcing teen to drink detergent mixture -Thanks for listening!Follow us on Facebook: facebook.com/VermontCatchup Follow Matt on twitter: @MatthewBorden4 Contact the show: 24theroadshow@gmail.comOutro Music by B-Complex

Let us know what you think - text the show!On this week's show:Happy National Salesperson DayMajestic 10 gets a liquor licenseBurlington City Council weighs graffiti ordinanceRutland's Cortina Inn gets temporarily shut downLawsuit alleges abuses in hotel program Vermont to Begin Testing Milk Supply for Bird Flu |Supreme Court Approves Demolition of Burlington CathedralVermont Construction Company citedMayor announces pick to create Burlington overdose prevention ceVermont Supreme Court rules in favor of Williston dog rescue VSP poke holes in Derby Line driver's shooting claim Bernie says next Senate term “probably his last”(52:15) Break music:  Caitlin Canty -”Odds of Getting Even”https://caitlincanty.bandcamp.com/album/come-by-the-highway-homeSaint Albans nuisance property lawA Moving Company Helps Seniors Make a Smooth Transition Cannabis company sues over free speechYou can buy weed in Sharon, VT Whatchu know ‘bout Sharon, VT?St Mikes research finds hope for Alzheimer's in spider brainsHandy Family Sells Notorious Church Street Apartment ComplexWe're big time now - getting a 2nd Jersey Mike's(1:34:48) Break music:  Dylan Patrick Ward - “Piles”https://dylanpatrickward.bandcamp.com/album/neer-do-wells Scumbag mapN.Y. Man sentenced on federal drug charge State upgrades homicide charges against Pownal stabber Rutland Scarface faces new chargesBarre police logMan hits cop with carThanks for listening!Follow us on Facebook: facebook.com/VermontCatchup Follow Matt on twitter: @MatthewBorden4 Contact the show: 24theroadshow@gmail.comOutro Music by B-Complex

Let us know what you think - text the show!On this week's show:Happy National Gazpacho DayAdam hates Front Porch ForumVermont endures record fall wildfire damage100 acres in SoBu now protectedPhil Scott cuts down his own xmas treeSanders, Welch and Balint seek reversal of decision to cut hours at Vermont Layoffs begin at federal immigration center in Essex. Employees fear more UVM Medical Center  rally against cutsSpay/neuter program saves money for pet ownersForest Service issues draft management plan for 72,000 acres in RutlandVisits to Vermont's state-owned historic sites reach 22-year high -Police say they believe Vermonter abducted in Philippines has died Water Bond Could Cost Burlington $225 Million |Government Seeks New Owner for Montpelier's Federal Building |Cortina Inn sanctioned Surveillance towers along the Canadian border(54:38) Break music:  Tommy Crawford - “EVACUATION”https://tommycrawford.bandcamp.com/track/evacuationBernie Sanders look alike contestDo you want to join a VT school board? No assistant attorney in RutlandPrivate fireworks show shut downFirst chicane season in Notch ruled a success Brattleboro to get an expensive bridgeTrouble ferments around Vermont distilleryCanada Post strike will affect NEK folksYou can drink outside at North Chair Brewing(1:28:04) Break music:  Roost.World - “Get to Work”https://roost.bandcamp.com/track/get-to-work-full-band Scumbag mapThieves target Kia vehicl es in South BurlingtonBrattleboro woman, 22, pleads guilty to 13 charges Violent Bennington AssaultsDeadly shooting in BristolBerlin burglarStabbing suspect turns himself inFake gun flashed in road rage incidentSwanton man arrested after high-speed chase and crash Fair Haven apartment blaze leads to resident's arrestThanks for listening!Follow us on Facebook: facebook.com/VermontCatchup Follow Matt on twitter: @MatthewBorden4 Contact the show: 24theroadshow@gmail.comOutro Music by B-Complex

Let us know what you think - text the show!On this week's show:Happy Black FridayJudge dismisses lawsuit against Burlington's short-term rental regulations -St. Albans landlords with problem properties could face fines under proposalHartland Planning Commission persists in farm store opposition -Something in the Rutland drinking waterIlona Maher is a finalist on Dancing with the StarsPhil Scott again appoints Zoie Saunders secretary of educationGov. Scott Wants to Move Back Climate TargetVermont department orders some workers back to the office40 new officers graduate from Vermont Police AcademyBurlington's dilapidated police building is dragging down department morale Wait…who is Heart Aerospace?(56:28) Break music: Wombaticus Rex - Anthembanger (Rico James remix)https://soundsofrico.bandcamp.com/track/anthembanger-rico-james-remix Mascot drama in FairfaxIce Cream UnionPlainfield Co-op balances nostalgia and growth with planned expansion |Freshly energized apprenticeship programs take on new industries Skida's Growing Hat Empire Is Turning Heads Activists Want to Remake Shelburne Road After Cyclist Is Killed Kraemer & Kin to Relocate in the Champlain Islands The Raider Reporter(1:35:46) Break music: Eric Mike Daniels - Wayward Feline Voguehttps://ericmikedaniels.bandcamp.com/track/wayward-feline-vogue Scumbag mapMan arrested for trying to run down stranger with car, police sayVt. man pleads not guilty to attempted murder in father's stabbingWoman assaults hospital guardRutland man jailed for assaultHartland rock robberGun threat neutralized in WaterburyThree people charged with living and defecating in historic Guilford cemetery Thanks for listening!Follow us on Facebook: facebook.com/VermontCatchup Follow Matt on twitter: @MatthewBorden4 Contact the show: 24theroadshow@gmail.comOutro Music by B-Complex

Let us know what you think - text the show!On this week's show:Happy National Flossing DayLet's acknowledge the electionHistoric Gains by Republicans Shift Montpelier's Balance of PowerWe can't bring our guns to the bar - is this even America?Burlington police chief Jon Murad will not seek reappointment City Council's plan for a safer downtownBurlington Council Proposes Steep Fees for Vacant Buildings Officer hits, kills bicyclist in South BurlingtonDavid Zuckerman concedes UVM Health Network announces widespread service cuts Burlington's only movie theater, Merrill's Roxy Cinema, to close its doors (53:59) Break music: watercoat - “Just Once in My Life”https://watercoat.bandcamp.com/track/just-once-in-my-life-2  Study group hesitant about psychedelic therapy in Vermont  In Brattleboro, a citizen journalist is breaking — and making — news Depression-era murals return to Bellows Falls New Land View Project on South Burlington South Burlington reconsiders non-citizen voting New border crossing hours PFAS in game meat More parades in RutlandOfficials urge caution as tick season becomes year-round Lil Jon coming  to 2025 Champlain Valley Fair(1:40:58) Break music: Coyote Reverie - “Thistledown”https://coyotereverie.bandcamp.com/track/thistledown Scumbag Map Don't peek - what is the cost for a ticket for 124 mph? Suspects in Rutland murder case kill wrong guyRutland man sentenced for drug trafficking Vt. man pleads not guilty to federal bank robbery chargesGroton stabber caught in NHWhatchu know bout Groton, VT? Man beats parents to deathBurglar used car to drag ATM into parking lotThanks for listening!Follow us on Facebook: facebook.com/VermontCatchup Follow Matt on twitter: @MatthewBorden4 Contact the show: 24theroadshow@gmail.comOutro Music by B-Complex

In this latest episode of Restoration Roundup, we speak with three farmers who made the decision to restore riparian areas on their land. First we spoke with Geo Honigford, a retired vegetable farmer from South Royalton, VT who sold his farm last year. We also spoke with Larry Trombley from Swanton, VT, a landowner who leases his land to farmers, who was particularly motivated by growing up in Vermont and seeing how agricultural production affected the health of the Missisquoi Bay. Finally, we spoke with Guy Choiniere, a third generation dairy farmer from Highgate Center, VT whose land is conserved through a land trust and won an Aldo Leopold award for his conservation work on the farm. Over 80% of Vermont land is privately owned, meaning that a big piece of the puzzle with restoring riparian areas is connecting farmers to opportunities to restore a riparian site. All three men were approached by the USDA to restore a riparian area on their land. Though a shared reservation many farmers have is the loss of their land to the forest, we discuss with Guy, Geo, and Larry how the programs they worked with helped navigate how to best support their surrounding land and ecosystems, while still ensuring a productive farm. Join us in this special episode of Restoration Roundup where we hear from farmers themselves on how their restoration projects changed how they view land management, what they learned, and the positive impacts they've seen the forests make on wildlife and their surrounding waterways. If you or someone you know is interested in restoring a riparian area, click the link below for finding support to restore a riparian forest on your land through the Vermont Agency of Agriculture CREP Program.

Let us know what you think - text the show!On this week's show:Happy National Cook for Your Pets DayHappy bday GloYankees demisePhil Scott's next victim?LT governor raceVT prisoners can voteBurlington has a syringe litter problemBurlington's pod community to seek 3-year extensionDon't burn your garbage(46:58) Break music: The Devil Makes Three - “Spirits”https://thedevilmakesthree.bandcamp.com/track/spirits  Burlington woman giving the dead back their names Possible overturning of excommunication Problem dog gets re-homedSouth Strafford school makes its own pledgeScience Pub series Zombie treesSave every wood turtleVT Witch trial(1:31:44) Break music: D.FRENCH feat Mavstar - “Still Got Weight”https://dfrench.bandcamp.com/track/still-got-weight-feat-mavstar Scumbag Map Philippines kidnapping suspects in custodyHandcuffed man hits copMontpelier brawl5 charged in downtown Burlington assaultFormer VT Senate candidate beat someone upCavalier bank robberGreedy embezzlerThanks for listening!Follow us on Facebook: facebook.com/VermontCatchup Follow Matt on twitter: @MatthewBorden4 Contact the show: 24theroadshow@gmail.comOutro Music by B-Complex

Let us know what you think - text the show!On this week's show:Happy National Frankenstein FridayYankees update?Springfield to vote on repealing gun ban in historic parkRudyard Kipling's historic Vermont home aims to weather changing times Vt. Teddy Bear, Vt. Flannel to open combined retail shop on Church Beta Technologies taking offBiden, Sanders tout prescription drug cost-savings at NH event Drug take back day in South BurlingtonMaybe we had the Montpelier knife melee on wrongVT Homicides on pace for new recordSoBu the safest city in America(49:04) Break music: Tall Travis - “Boston Accent”https://talltravis.bandcamp.com/track/boston-accent  Cheese truck crash Do you want to buy a fire truck?We're never getting the diverging diamondHandy's must pay for parking lot violationsStop the Sidewalks in HuntingtonUVM students get benches at bus stopsVTSU to build meat processing plant on Randolph campusSalon owner needs to pay back loanInvasive jumping worms(1:35:18) Break music: lily seabird - “fuckhead (acoustic)”https://lilyseabird.bandcamp.com/track/fuckhead-acoustic Scumbag Map  Barre police log Ever wake up in Ontario?Vermonter kidnapped in Philippines Baseball bat killer attacks corrections officerMan rams stolen car into police cruiserStabbing over 20 bucksThanks for listening!Follow us on Facebook: facebook.com/VermontCatchup Follow Matt on twitter: @MatthewBorden4 Contact the show: 24theroadshow@gmail.comOutro Music by B-Complex

Let us know what you think - text the show!On this week's show:Happy National Necktie DayThe wedding is off!...and back onDairy workers report unsafe work, low payAmazon to pay $400,000 in settlement over Vermont ban on tobacco product salesDoctor sues Vermont's former prison health care provider alleging fraudShortage of IV fluids could force hospitals to postpone procedures Norwich University student newspaper can resume publishing, but with ‘ethics reviwwOrvis cutting jobs, mail-order business Ballot Item Asks Burlington Voters to Bolster Police OversightYou can't bring your gun to a polling placeVermont Man Dies After Contracting Rare EEE Virus Bove Brothers Add Burlington Properties to Real Estate Empire Burlington Electric seeks to buy out city's wood-burning plant VT population only up a bit(51:45) Break music: Vallory Falls (Richmond) - “Art School (Time to Leave)”https://valloryfalls.bandcamp.com/track/art-school-time-to-leave Goddard's Latest Buyer Envisions Housing, Art Studios Massive comic book collection up for saleGPS goat collars make debutPitch a friend dating eventAirport eatery to closeWoodstock places police chief on paid leave Brattleboro struggles with firefighter staffing Church Street looking for next Xmas tree(1:19:31)  Break music: Midnight Atlantic - “The End of Summer”https://midnightatlantic.bandcamp.com/track/the-end-of-summer Scumbag Map  Ethan Allen Homestead Museum burglarized but exhibits were untouched One Man's Buying Spree Exposes the Drugs-for-Guns Trade in VTVT man stopped w/ guns and drugs Richford gun incident Montpelier knife fightWoman punches people at a group homeNaples statue  erectedThanks for listening!Follow us on Facebook: facebook.com/VermontCatchup Follow Matt on twitter: @MatthewBorden4 Contact the show: 24theroadshow@gmail.comOutro Music by B-Complex

Let us know what you think - text the show!On this week's show:Happy National Chocolate Milk DayYankee check in?VT Attorney general race is interestingEEE on the declineGet your gut checkedMultigenerational housing in JerichoVermont's only national park could expandThe state wants to build a new women's prison. We got a wild dogVermont's large st corn maze(52:36) Break music: Nahte Renmus (Feat Art Morera) - “Accolades”https://www.youtube.com/watch?v=jmVriG9oOmE&ab_channel=NahteRenmus Vt. elementary school children mistakenly eat THC gummies South Burlington secures bus drivers amidst nationwide shortageWalmart moving to Rutland mallBrattleboro park closed to get rid of Japanese….plantsMichigan University to Open New Dental School in Vermont Have we talked about Beansie's? Vermont has 'rules' for the way you should eat apple pie  Vermont regulators to stop accepting new retail cannabis applications Goddard Buyers Envision 'Bustling, Busy Campus Again' Judge dismisses senators' lawsuit over education secretary (1:26:24)  Break music: Tiger Strike - “Sundering”https://tigerstrikevt.bandcamp.com/track/sundering Scumbag Map Drunk driver hits cars and boatsSaint Albans man robs community kitchen Saint Albans clerk robbed at knifepoint Good cop: Burglary in process foiledBad cop: Cop assaults person over jaywalkingStabbing in Battery ParkMan shot in chest in RutlandPawlet triple murderTheft at Dog Mountain Thanks for listening!Follow us on Facebook: facebook.com/VermontCatchup Follow Matt on twitter: @MatthewBorden4 Contact the show: 24theroadshow@gmail.comOutro Music by B-Complex

Let us know what you think - text the show!On this week's show:Happy National Biscuits and Gravy WeekVermont is searching for EEE, one mosquito at a time UVMMC has too much moneyMental Health Urgent Care center closer to opening in BurlingtonBurlington says “Whoops, we might need cops”Vermont State University Enrollment Rises Fatal plane crashA bright leaf seasonTunbridge World FairThe hunt is on for Essex's best tree(48:36) Break music: Long Gone John & TallGrass GetDown - “Aint Gotta Think About You”https://longgonejohn.bandcamp.com/album/songs-for-ophelia Celebrity waiters at Ronald McDonald HouseBurlington may lower speed limitOlympian Ilona Maher to Compete on 'Dancing With the Stars' Progress on Sound MitigationWhat to do with Roxbury Village School buildingMorristown sees rise in car theftRutland competitive BBQ teamWhoopie pies return  to Rutland(1:19:11)  Break music: Real Ova Deceit (feat Doctor A) - “Going For it”https://www.youtube.com/watch?v=nrXMBVsleG8&ab_channel=RealOvaDeceitLLC Scumbag Map  Loose dogs cause crashVermont's Roman Catholic Diocese faces another wave of lawsuits Cedar Drive aka New Hamsterdam in BerlinNew Hampshire man pleads not guilty to Vermont murder Suspected bank robbers remain in jail | Local News | Royalton police officer facing domestic violence charges placed on leave  Banyai arrested…againWest Glover murder Bennington man arraigned on attempted murder after victim jumps from windowBucky the buckethead dog returned to ownerThanks for listening!Follow us on Facebook: facebook.com/VermontCatchup Follow Matt on twitter: @MatthewBorden4 Contact the show: 24theroadshow@gmail.comOutro Music by B-Complex

Let us know what you think - text the show!On this week's show:Happy National Coloring Book dayGlo's skunk updateWhoop there it is / who let the dogs outWhy does Vermont keep flooding? Cheif Murad doesn't like repeat offendersBurlington rugby star Ilona Maher wins Olympic bronze Vote for the ghost of Dick Sears Accidental Covid-19 case dismissedTraffic-calming devices installed on busy Burlington street New UVM surgical office approvedVermont in top 10 states with most federal disaster declarations (1:01:23) Break music: Suburban Samurai - "Zombie" https://suburbansamuraimusic.bandcamp.com/track/zombie  Sage Farm Goat Dairy wins national award South Burlington City Council bounces pickleball solutions Brazen bears rattle Stowe Giant pinecone-like egg statue coming to new Williston art park Resort planned for former SVC campus 'advancing'Dog Mountain cancels summer festival(1:41:10)  Break music: Violet Crimes - "Some Exceptions May Apply" https://violetcrimesvt.bandcamp.com/track/some-exceptions-may-apply Scumbag Map  Driver intentionally drives wrong wayImpressive shoplifting in Bellows Falls & Brattleboro Brandon teen charged with sex assaultWaterbury man arrested for Morristown murderMontpelier bat attack 77-year-old Bennington woman charged with trying to grab gun from police officer 18-year-old arraigned on felony charges after violent attacks in BenningtonSpringfield man faces multiple drug chargesChinese turtle smuggler convictedThanks for listening!Follow us on Facebook: facebook.com/VermontCatchup Follow Matt on twitter: @MatthewBorden4 Contact the show: 24theroadshow@gmail.comOutro Music by B-Complex

Let us know what you think - text the show!Happy National Talk in An Elevator DayReopened investigation into Smuggs drowning concludes One year into the Vermont State Uni systemVermont State Police confirm found remains belong to Roberta Martin Woodstock voters to decide on short term rentalsOutright Vermont wants to boycott twitterParents left scrambling after state revokes license of Richford child careECHO Leahy Center to embark on $3M exhibit renovation Cuarto Torres to get a faceliftSara Holbrook Community Center to closeAn inmate's pleas about her dangerous cellmate were dismissed. Then she You gotta trust your shroom guyBreak music: Dylan Patrick Ward & the Loveable Losers - “I cant wait to be alone”https://dylanpatrickward.bandcamp.com/track/i-cant-wait-to-be-alone New Digger managing editorVT rowers headed to OlympicsWest Nile virus in Alburgh mosquito poolTito's Taqueria fined by Dept of LaborCrazy Cat Lady Ceramics81.1% of Vermont Lakes Are Too Polluted for Swimming Top ice creams flavors in VT: Did your favorite make the list? ()  Break music: Mavstar (feat Joint Manipulation) - Mavstar City https://mavstar.bandcamp.com/track/mavstar-city-feat-joint-manipulation-2 Scumbag Map  Man arrested in South Burlington on aggravated assault, kidnapping, and buThree charged in Kayla Wright homicide case - Lunenburg man jailed after rampage at St. Johnsbury transportation building  Essex police officer assaultedAssault case of Franklin County Sheriff John Grismore ends in mistrialRutland girls trying to make the world safer for turtlesThanks for listening!Follow us on Facebook: facebook.com/VermontCatchup Follow Matt on twitter: @MatthewBorden4 Contact the show: 24theroadshow@gmail.comOutro Music by B-Complex

Let us know what you think - text the show!On this week's show:Happy National Lottery DayLaw enforcement uses roadblock to find jurors Man shot by police in Burke charged w/ attempted aggravated murder oSaint albans woman deported rather quicklyBurlington trying to fix old pipes1st leg of Burlington's Champlain Parkway set to open this summHigher Ground says Burton pulled plug on South End move UVM Staff Union Asks University to Reinstate Mental Health Positions Burial Mix-Up at  Burlington's Lakeview Cemetery  (52:15) Break music: Trevor Robinson - The Last Pay Phone on Earth https://trevorrobinson.bandcamp.com/track/the-very-last-pay-phone-on-earth Goddard College Campus Is Back on the Market |251 club celebrates 70 years Fairfax town-wide garage sale Library / Police Station in Rutland? European tree technology comes to Montpelier Thai Kitchen in MiltonBurlington City Council to discuss police oversight Creemee Confidential: What It Takes to Create Vermont's Dessert(1:31:04)  Break music: The Owl Stars - Hit Em for Me https://citizenbare.bandcamp.com/track/hit-em-for-me Scumbag Map  Man hospitalized after shot by pellet gun in BrattleboroElusive fugitive captured in Burlington Former Vermont trooper stripped of certification Burglars caught on camera at state park Woman assaults, robs seniors on Church StreetPolice try to ID woman involved in SUV theft, car break-ins  Man pulls a Supermarket Sweep in BerlinThanks for listening!Follow us on Facebook: facebook.com/VermontCatchup Follow Matt on twitter: @MatthewBorden4 Contact the show: 24theroadshow@gmail.comOutro Music by B-Complex

Let us know what you think - text the show!On this week's show:Happy national Rock n Roll DayAdam had a baby!UVM Nurses strike dealWhistleblower Alleges iSun Leaders Misled Shareholders Manhattan Pizza & Pub WalkoutAddison drunk prosecutor settlesVermont launches problem gambling websiteLaw aimed to protect cyclists New VT law cracks down on thefts Ethan Allen Express getting fasterOne  contractor carted away thousands of tons of flood debrisSpecial state park beer of Vermont(1:12:15) Break music: Nahte Renmus (Feat Jarv) - “Puddin' Cup”https://www.youtube.com/watch?v=Ro7MeHaLvMw&ab_channel=NahteRenmus  Folks pissed about PickleballRecycling household batteries is now the lawNo quarry in Saint AlbansGreat Bristol Outhouse RaceSale price for Goddard College's campus is $3.4 million;  Hundreds sign up for refugee assistance training Changes at Jericho General storeBarton woman regains home in tax sale settlement Future of movies in VT?(1:53:40)  Break music: Lutalo - “Ocean Swallows Him Whole”https://lutalo.bandcamp.com/album/the-academy Scumbag Map Teen driving 107 mph Man hit several cars VT police search for hit & run Man wanted for dragging officer Burlington knife threat Bennington man escape does not go well Saint Albans crime roundup Chinese turtle smugglerThanks for listening!Follow us on Facebook: facebook.com/VermontCatchup Follow Matt on twitter: @MatthewBorden4 Contact the show: 24theroadshow@gmail.comOutro Music by B-Complex

"Nothing like it since movies were created! 300 Girls, 1000 Surprises, 5 New Song Hits!" The musical team of Hass & Swanton (Kyle Reid Hass & Jeremy Swanton) return to the show once again, this time for what is inarguably the greatest movie musical about putting on live prologues before movie screenings ever to hit the silver screen, Footlight Parade (1933)! We'll talk Cagney, Berkeley, and folks getting frisky at the "Honeymoon Hotel". Plus, we talk about Hass & Swanton's new musical TV series, Act of Faith! Hosts:Michael NataleTwitterLetterboxd Tom LorenzoTwitterLetterboxd Producer:Kyle Lampar Guest:Kyle Reid Hass & Jeremy SwantonAct of FaithYouTubeWebsite Follow the Show:TwitterInstagramWebsite Music by Mike Natale

Send us a Text Message.Discover the secrets to navigating the ever-changing Las Vegas real estate market with our special guest, Sharon Swanton from Affinity Coaching. With nearly 4,000 active listings, the market shows promising resilience despite a noticeable slowdown. We'll unpack the significance of recent sales, price reductions, and properties under contract, offering you invaluable insights to stay ahead of market fluctuations. Sharon will guide us through the cyclical nature of real estate, providing you with the tools to anticipate trends and make informed decisions, even during election season uncertainties.Have you ever felt overwhelmed by the burdens of responsibility? Sharon Swanton sheds light on how childhood experiences shape our perceptions of control in adulthood. We delve into the psychological aspects of responsibility, helping you distinguish between what you can and cannot control. Learn how focusing on your reactions rather than external events can dramatically improve your emotional and mental well-being. This conversation is a must-listen for anyone aiming to enhance their resilience and emotional intelligence in the face of life's challenges.Election seasons can be particularly stressful, especially for professionals in unpredictable fields like real estate. Sharon and I discuss how to navigate this anxiety by managing expectations and maintaining a steady hand. We explore the importance of understanding client needs, differentiating your property in a competitive market, and the emotional labor involved in real estate. Gain practical advice on balancing responsibilities and setting realistic expectations to ensure success. This episode is packed with actionable insights and thoughtful discussions designed to empower you both personally and professionally.Support the Show.Welcome to Vegas Realty Check, the informative podcast that dives deep into the world of Las Vegas real estate. Our expert hosts break down the complexities of the ever-changing Las Vegas property market, analyze market trends, economic indicators, and unique property features to provide you with valuable insights on timing your home sale or purchase. Don't miss out on the fun! New episodes drop every Thursday! Stay in the know about Las Vegas real estate with insights straight from the pros . Thanks for watching, listening, and sharing! If you LOVE our content , Please subscribe to our show here https://www.buzzsprout.com/1428685/support Linktree https://linktr.ee/vegasrealtycheck?utm_source=linktree_profile_share<sid=665d8181-2204-45fb-b56f-e8ed3efbfd18Send Listener Questions to : VegasRealtyCheck@gmail.comAccess All Episodes at RealtyCheck.VegasWatch Live on Facebook Thursdays @9:30am PST https://www.facebook.com/VegasRealtyCheck Linktree https://linktr.ee/vegasrealtycheck?utm_sourc...

Let us know what you think - text the show!On this week's show:Happy National Vanilla Milkshake DayFried chicken comment2 Vermont senators sue Gov. Phil Scott Burlington Mayor Dodges Media Conservative group challenges non-citizen votingVt. marijuana company questions authority of Cannabis Control Board Nurses union at UVM Medical Center threatens strike More than 4 million skiers braved Vermont's weird, wet winter VT national guards graduate from Brazilian mountain school(51:18) Break music: The Steppes - "Dynamite"https://thesteppes.bandcamp.com/track/dynamiteZoning middle finger in Huntington Historic temperaturesLifeguard shortage Murder Case Against a Burlington Teen Has Been Moved to Juvenile Court Montpelier distillery celebrates Pollinator Week New mural captures camaraderie of Old North End neighborhood Consultant deems Vermont health care system ‘badly broken' Work continues on new Montpelier post office location (1:35:26)  Break music: Kiley Latham - “Daydream”Scumbag Map Three in custody after manhunt in Northeast Kingdom VT. Man charged in ‘Whitey' Bulger death pleads guilty Man kidnaps woman, childSecond teen arraigned on gang sexual assault at drinking party Arrest serves as a cautionary tale for selling vehicles online  Melee in the parkFive men arrested after Springfield drug bust  Fairfax man in his best polo assaults officer Grand Isle man arrested for waving gun, holding up trafficBarre dealership's ex-auto parts director admits to $575K fraud scheme  Need volunteers for goose bandingThanks for listening!Follow us on Facebook: facebook.com/VermontCatchup Follow Matt on twitter: @MatthewBorden4 Contact the show: 24theroadshow@gmail.comIOutro Music by B-Complex

The most enthralling conversation I've ever had with anyone on cancer. It's with Charlie Swanton who is a senior group leader at the Francis Crick Institute, the Royal Society Napier Professor in Cancer and medical oncologist at University College London, co-director of Cancer Research UK.Video snippet from our conversation. Full videos of all Ground Truths podcasts can be seen on YouTube here. The audios are also available on Apple and Spotify.Transcript with audio links and many external linksEric Topol (00:07):Well, hello, this is Eric Topol with Ground Truths, and I am really fortunate today to connect us with Charlie Swanton, who is if not the most prolific researcher in the space of oncology and medicine, and he's right up there. Charlie is a physician scientist who is an oncologist at Francis Crick and he heads up the lung cancer area there. So Charlie, welcome.Charles Swanton (00:40):Thank you, Eric. Nice to meet you.Learning from a FailureEric Topol (00:43):Well, it really is a treat because I've been reading your papers and they're diverse. They're not just on cancer. Could be connecting things like air pollution, it could be Covid, it could be AI, all sorts of things. And it's really quite extraordinary. So I thought I'd start out with a really interesting short paper you wrote towards the end of last year to give a sense about you. It was called Turning a failing PhD around. And that's good because it's kind of historical anchoring. Before we get into some of your latest contributions, maybe can you tell us about that story about what you went through with your PhD?Charles Swanton (01:26):Yeah, well thank you, Eric. I got into research quite early. I did what you in the US would call the MD PhD program. So in my twenties I started a PhD in a molecular biology lab at what was then called the Imperial Cancer Research Fund, which was the sort of the mecca for DNA tumor viruses, if you like. It was really the place to go if you wanted to study how DNA tumor viruses worked, and many of the components of the cell cycle were discovered there in the 80s and 90s. Of course, Paul Nurse was the director of the institute at the time who discovered cdc2, the archetypal regulator of the cell cycle that led to his Nobel Prize. So it was a very exciting place to work, but my PhD wasn't going terribly well. And sort of 18, 19 months into my PhD, I was summoned for my midterm reports and it was not materializing rapidly enough.(02:25):And I sat down with my graduate student supervisors who were very kind, very generous, but basically said, Charlie, this isn't going well, is it? You've got two choices. You can either go back to medical school or change PhD projects. What do you want to do? And I said, well, I can't go back to medical school because I'm now two years behind. So instead I think what I'll do is I'll change PhD projects. And they asked me what I'd like to do. And back then we didn't know how p21, the CDK inhibitor bound to cyclin D, and I said, that's what I want to understand how these proteins interact biochemically. And they said, how are you going to do that? And I said, I'm not too sure, but maybe we'll try yeast two-hybrid screen and a mutagenesis screen. And that didn't work either. And in the end, something remarkable happened.(03:14):My PhD boss, Nic Jones, who's a great guy, still is, retired though now, but a phenomenal scientist. He put me in touch with a colleague who actually works next door to me now at the Francis Crick Institute called Neil McDonald, a structural biologist. And they had just solved, well, the community had just solved the structure. Pavletich just solved the structure of cyclin A CDK2. And so, Neil could show me this beautiful image of the crystal structure in 3D of cyclin A, and we could mirror cyclin D onto it and find the surface residue. So I spent the whole of my summer holiday mutating every surface exposed acid on cyclin D to an alanine until I found one that failed to interact with p21, but could still bind the CDK. And that little breakthrough, very little breakthrough led to this discovery that I had where the viral cyclins encoded by Kaposi sarcoma herpes virus, very similar to cyclin D, except in this one region that I had found interactive with a CDK inhibitor protein p21.(04:17):And so, I asked my boss, what do you think about the possibility this cyclin could have evolved from cyclin D but now mutated its surface residues in a specific area so that it can't be inhibited by any of the control proteins in the mammalian cell cycle? He said, it's a great idea, Charlie, give it a shot. And it worked. And then six months later, we got a Nature paper. And that for me was like, I cannot tell you how exciting, not the Nature paper so much as the discovery that you were the first person in the world to ever see this beautiful aspect of evolutionary biology at play and how this cyclin had adapted to just drive the cell cycle without being inhibited. For me, just, I mean, it was like a dream come true, and I never experienced anything like it before, and I guess it's sizes the equivalent to me of a class A drug. You get such a buzz out of it and over the years you sort of long for that to happen again. And occasionally it does, and it's just a wonderful profession.Eric Topol (05:20):Well, I thought that it was such a great story because here you were about to fail. I mean literally fail, and you really were able to turn it around and it should give hope to everybody working in science out there that they could just be right around the corner from a significant discovery.Charles Swanton (05:36):I think what doesn't break you makes you stronger. You just got to plow on if you love it enough, you'll find a way forward eventually, I hope.Tracing the Evolution of Cancer (TRACERx)Eric Topol (05:44):Yeah, no question about that. Now, some of your recent contributions, I mean, it's just amazing to me. I just try to keep up with the literature just keeping up with you.Charles Swanton (05:58):Eric, it's sweet of you. The first thing to say is it's not just me. This is a big community of lung cancer researchers we have thanks to Cancer Research UK funded around TRACERx and the lung cancer center. Every one of my papers has three corresponding authors, multiple co-first authors that all contribute in this multidisciplinary team to the sort of series of small incremental discoveries. And it's absolutely not just me. I've got an amazing team of scientists who I work with and learn from, so it's sweet to give me the credit.Eric Topol (06:30):I think what you're saying is really important. It is a team, but I think what I see through it all is that you're an inspiration to the team. You pull people together from all over the world on these projects and it's pretty extraordinary, so that's what I would say.Charles Swanton (06:49):The lung community, Eric, the lung cancer community is just unbelievably conducive to collaboration and advancing understanding of the disease together. It's just such a privilege to be working in this field. I know that sounds terribly corny, but it is true. I don't think I recall a single email to anybody where I've asked if we can collaborate where they've said, no, everybody wants to help. Everybody wants to work together on this challenge. It's just such an amazing field to be working in.Eric Topol (07:19):Yeah. Well I was going to ask you about that. And of course you could have restricted your efforts or focused on different cancers. What made you land in lung cancer? Not that that's only part of what you're working on, but that being the main thing, what drew you to that area?Charles Swanton (07:39):So I think the answer to your question is back in 2008 when I was looking for a niche, back then it was lung cancer was just on the brink of becoming an exciting place to work, but back then nobody wanted to work in that field. So there was a chair position in thoracic oncology and precision medicine open at University College London Hospital that had been open, as I understand it for two years. And I don't think anybody had applied. So I applied and because I was the only one, I got it and the rest is history.(08:16):And of course that was right at the time when the IPASS draft from Tony Mok was published and was just a bit after when the poster child of EGFR TKIs and EGFR mutant lung cancer had finally proven that if you segregate that population of patients with EGFR activating mutation, they do incredibly well on an EGFR inhibitor. And that was sort of the solid tumor poster child along with Herceptin of precision medicine, I think. And you saw the data at ASCO this week of Lorlatinib in re-arranged lung cancer. Patients are living way beyond five years now, and people are actually talking about this disease being more like CML. I mean, it's extraordinary the progress that's been made in the last two decades in my short career.Eric Topol (09:02):Actually, I do want to have you put that in perspective because it's really important what you just mentioned. I was going to ask you about this ASCO study with the AKT subgroup. So the cancer landscape of the lung has changed so much from what used to be a disease of cigarette smoking to now one of, I guess adenocarcinoma, non-small cell carcinoma, not related to cigarettes. We're going to talk about air pollution in a minute. This group that had, as you say, 60 month, five year plus survival versus what the standard therapy was a year plus is so extraordinary. But is that just a small subgroup within small cell lung cancer?Charles Swanton (09:48):Yes, it is, unfortunately. It's just a small subgroup. In our practice, probably less than 1% of all presentations often in never smokers, often in female, never smokers. So it is still in the UK at least a minority subset of adenocarcinomas, but it's still, as you rightly say, a minority of patients that we can make a big difference to with a drug that's pretty well tolerated, crosses the blood-brain barrier and prevents central nervous system relapse and progression. It really is an extraordinary breakthrough, I think. But that said, we're also seeing advances in smoking associated lung cancer with a high mutational burden with checkpoint inhibitor therapy, particularly in the neoadjuvant setting now prior to surgery. That's really, really impressive indeed. And adjuvant checkpoint inhibitor therapies as well as in the metastatic setting are absolutely improving survival times and outcomes now in a way that we couldn't have dreamt of 15 years ago. We've got much more than just platinum-based chemo is basically the bottom line now.Revving Up ImmunotherapyEric Topol (10:56):Right, right. Well that actually gets a natural question about immunotherapy also is one of the moving parts actually just amazing to me how that's really, it's almost like we're just scratching the surface of immunotherapy now with checkpoint inhibitors because the more we get the immune system revved up, the more we're seeing results, whether it's with vaccines or CAR-T, I mean it seems like we're just at the early stages of getting the immune system where it needs to be to tackle the cancer. What's your thought about that?Charles Swanton (11:32):I think you're absolutely right. We are, we're at the beginning of a very long journey thanks to Jim Allison and Honjo. We've got CTLA4 and PD-1/PDL-1 axis to target that's made a dramatic difference across multiple solid tumor types including melanoma and lung cancer. But undoubtedly, there are other targets we've seen LAG-3 and melanoma and then we're seeing new ways, as you rightly put it to mobilize the immune system to target cancers. And that can be done through vaccine based approaches where you stimulate the immune system against the patient's specific mutations in their cancer or adoptive T-cell therapies where you take the T-cells out of the tumor, you prime them against the mutations found in the tumor, you expand them and then give them back to the patient. And colleagues in the US, Steve Rosenberg and John Haanen in the Netherlands have done a remarkable job there in the context of melanoma, we're not a million miles away from European approvals and academic initiated manufacturing of T-cells for patients in national health systems like in the Netherlands.(12:50):John Haanen's work is remarkable in that regard. And then there are really spectacular ways of altering T-cells to be able to either migrate to the tumor or to target specific tumor antigens. You mentioned CAR-T cell therapies in the context of acute leukemia, really extraordinary developments there. And myeloma and diffuse large B-cell lymphoma as well as even in solid tumors are showing efficacy. And I really am very excited about the future of what we call biological therapies, be it vaccines, an antibody drug conjugates and T-cell therapies. I think cancer is a constantly adapting evolutionary force to be reckoned with what better system to combat it than our evolving immune system. It strikes me as being a future solution to many of these refractory cancers we still find difficult to treat.Eric Topol (13:48):Yeah, your point is an interesting parallel how the SARS-CoV-2 virus is constantly mutating and becoming more evasive as is the tumor in a person and the fact that we can try to amp up the immune system with these various means that you just were reviewing. You mentioned the other category that's very hot right now, which is the antibody drug conjugates. Could you explain a bit about how they work and why you think this is an important part of the future for cancer?Antibody-Drug ConjugatesCharles Swanton (14:26):That's a great question. So one of the challenges with chemotherapy, as you know, is the normal tissue toxicity. So for instance, neutropenia, hair loss, bowel dysfunction, diarrhea, epithelial damage, essentially as you know, cytotoxics affect rapidly dividing tissues, so bone marrow, epithelial tissues. And because until relatively recently we had no way of targeting chemotherapy patients experienced side effects associated with them. So over the last decade or so, pioneers in this field have brought together this idea of biological therapies linked with chemotherapy through a biological linker. And so one poster chart of that would be the drug T-DXd, which is essentially Herceptin linked to a chemotherapy drug. And this is just the most extraordinary drug that obviously binds the HER2 receptor, but brings the chemotherapy and proximity of the tumor. The idea being the more drug you can get into the tumor and the less you're releasing into normal tissue, the more on tumor cytotoxicity you'll have and the less off tumor on target normal tissue side effects you'll have. And to a large extent, that's being shown to be the case. That doesn't mean they're completely toxicity free, they're not. And one of the side effects associated with these drugs is pneumonitis.(16:03):But that said, the efficacy is simply extraordinary. And for example, we're having to rewrite the rule books if you like, I think. I mean I'm not a breast cancer physician, I used to be a long time ago, but back in the past in the early 2000s, there was HER2 positive breast cancer and that's it. Now they're talking about HER2 low, HER2 ultra-low, all of which seem to in their own way be sensitive to T-DXd, albeit to a lower extent than HER2 positive disease. But the point is that there doesn't seem to be HER2 completely zero tumor group in breast cancer. And even the HER2-0 seem to benefit from T-DXd to an extent. And the question is why? And I think what people are thinking now is it's a combination of very low cell service expression of HER2 that's undetectable by conventional methods like immunohistochemistry, but also something exquisitely specific about the way in which HER2 is mobilized on the membrane and taken back into the cell. That seems to be specific to the breast cancer cell but not normal tissue. So in other words, the antibody drug conjugate binds the tumor cell, it's thought the whole receptor's internalized into the endosome, and that's where the toxicity then happens. And it's something to do with the endosomal trafficking with the low level expression and internalization of the receptor. That may well be the reason why these HER2 low tumors are so sensitive to this beautiful technology.Eric Topol (17:38):Now I mean it is an amazing technology in all these years where we just were basically indiscriminately trying to kill cells and hoping that the cancer would succumb. And now you're finding whether you want to call it a carry or vector or Trojan horse, whatever you want to call it, but do you see that analogy of the HER2 receptor that's going to be seen across the board in other cancers?Charles Swanton (18:02):That's the big question, Eric. I think, and have we just lucked out with T-DXd, will we find other T-DXd like ADCs targeting other proteins? I mean there are a lot of ADCs being developed against a lot of different cell surface proteins, and I think the jury's still out. I'm confident we will, but we have to bear in mind that biology is a fickle friend and there may be something here related to the internalization of the receptor in breast cancer that makes this disease so exquisitely sensitive. So I think we just don't know yet. I'm reasonably confident that we will find other targets that are as profoundly sensitive as HER2 positive breast cancer, but time will tell.Cancer, A Systemic DiseaseEric Topol (18:49):Right. Now along these lines, well the recent paper that you had in Cell, called embracing cancer complexity, which we've talking about a bit, in fact it's kind of those two words go together awfully well, but hallmarks of systemic disease, this was a masterful review, as you say with the team that you led. But can you tell us about what's your main perspective about this systemic disease? I mean obviously there's been the cancer is like cardiovascular and cancers like this or that, but here you really brought it together with systemic illness. What can you say about that?Charles Swanton (19:42):Well, thanks for the question first of all, Eric. So a lot of this comes from some of my medical experience of treating cancer and thinking to myself over the years, molecular biology has had a major footprint on advances in treating the disease undoubtedly. But there are still aspects of medicine where molecular biology has had very little impact, and often that is in areas of suffering in patients with advanced disease and cancer related to things like cancer cachexia, thrombophilia. What is the reason why patients die blood clots? What is the reason patients die of cancer at all? Even a simple question like that, we don't always know the answer to, on death certificates, we write metastatic disease as a cause of cancer death, but we have patients who die with often limited disease burden and no obvious proximal cause of death sometimes. And that's very perplexing, and we need to understand that process better.(20:41):And we need to understand aspects like cancer pain, for example, circadian rhythms affect biological sensitivity of cancer cells to drugs and what have you. Thinking about cancer rather than just sort of a single group of chaotically proliferating cells to a vision of cancer interacting both locally within a microenvironment but more distantly across organs and how organs communicate with the cancer through neuronal networks, for example, I think is going to be the next big challenge by setting the field over the next decade or two. And I think then thinking about more broadly what I mean by embracing complexity, I think some of that relates to the limitations of the model systems we use, trying to understand inter-organ crosstalk, some of the things you cover in your beautiful Twitter reviews. (←Ground Truths link) I remember recently you highlighted four publications that looked at central nervous system, immune cell crosstalk or central nervous system microbiome crosstalk. It's this sort of long range interaction between organs, between the central nervous system and the immune system and the cancer that I'm hugely interested in because I really think there are vital clues there that will unlock new targets that will enable us to control cancers more effectively if we just understood these complex networks better and had more sophisticated animal model systems to be able to interpret these interactions.Eric Topol (22:11):No, it's so important what you're bringing out, the mysteries that still we have to deal with cancer, why patients have all these issues or dying without really knowing what's happened no less, as you say, these new connects that are being discovered at a remarkable pace, as you mentioned, that ground truths. And also, for example, when I spoke with Michelle Monje, she's amazing on the cancer, where hijacking the brain cells and just pretty extraordinary things. Now that gets me to another line of work of yours. I mean there are many, but the issue of evolution of the tumor, and if you could put that in context, a hot area that's helping us elucidate these mechanisms is known as spatial omics or spatial biology. This whole idea of being able to get the spatial temporal progression through single cell sequencing and single cell nuclei, all the single cell omics. So if you could kind of take us through what have we learned with this technique and spatial omics that now has changed or illuminated our understanding of how cancer evolves?Charles Swanton (23:37):Yeah, great question. Well, I mean I think it helps us sort of rewind a bit and think about evolution in general. Genetic selection brought about by diverse environments and environmental pressures that force evolution, genetic evolution, and speciation down certain evolutionary roots. And I think one can think about cancers in a similar way. They start from a single cell and we can trace the evolutionary paths of cancers by single cell analysis as well as bulk sequencing of spatially separated tumor regions to be able to reconstruct their subclones. And that's taught us to some extent, what are the early events in tumor evolution? What are the biological mechanisms driving branched evolution? How does genome instability begin in tumors? And we found through TRACERx work, whole genome doubling is a major route through to driving chromosome instability along with mutagenic enzymes like APOBEC that drive both mutations and chromosomal instability.(24:44):And then that leads to a sort of adaptive radiation in a sense, not dissimilar to I guess the Cambrian explosion of evolutionary opportunity upon which natural selection can act. And that's when you start to see the hallmarks of immune evasion like loss of HLA, the immune recognition molecules that bind the neoantigens or even loss of the neoantigens altogether or mutation of beta 2 microglobulin that allow the tumor cells to now evolve below the radar, so to speak. But you allude to the sort of spatial technologies that allow us to start to interpret the microenvironments as well. And that then tells us what the evolutionary pressures are upon the tumor. And we're learning from those spatial technologies that these environments are incredibly diverse, actually interestingly seem to be converging on one important aspect I'd like to talk to you a little bit more about, which is the myeloid axis, which is these neutrophils, macrophages, et cetera, that seem to be associated with poor outcome and that will perhaps talk about pollution in a minute.(25:51):But I think they're creating a sort of chronic inflammatory response that allows these early nascent tumor cells to start to initiate into frankly tumor invasive cells and start to grow. And so, what we're seeing from these spatial technologies in lung cancer is that T-cells, predatory T-cells, force tumors to lose their HLA molecules and what have you to evade the immune system. But for reasons we don't understand, high neutrophil infiltration seems to be associated with poor outcome, poor metastasis free survival. And actually, those same neutrophils we've recently found actually even tracked to the metastasis sites of metastasis. So it's almost like this sort of symbiosis between the myeloid cells and the tumor cells in their biology and growth and progression of the tumor cells.Eric Topol (26:46):Yeah, I mean this white cell story, this seems to be getting legs and is relatively new, was this cracked because of the ability to do this type of work to in the past everything was, oh, it's cancer's heterogeneous and now we're getting pinpoint definition of what's going on.Charles Swanton (27:04):I think it's certainly contributed, but it's like everything in science, Eric, when you look back, there's evidence in the literature for pretty much everything we've ever discovered. You just need to put the pieces together. And I mean one example would be the neutrophil lymphocyte ratio in the blood as a hallmark of outcome in cancers and to checkpoint inhibitor blockade, maybe this begins to explain it, high neutrophils, immune suppressive environment, high neutrophils, high macrophages, high immune suppression, less benefit from checkpoint inhibitor therapy, whereas you want lymphocyte. So I think there are biomedical medical insights that help inform the biology we do in the lab that have been known for decades or more. And certainly the myeloid M2 axis in macrophages and what have you was known about way before these spatial technologies really came to fruition, I think.The Impact of Air PollutionEric Topol (28:01):Yeah. Well you touched on this about air pollution and that's another dimension of the work that you and your team have done. As you well know, there was a recent global burden of disease paper in the Lancet, which has now said that air pollution with particulate matter 2.5 less is the leading cause of the burden of disease in the world now.Charles Swanton (28:32):What did you think of that, Eric?Eric Topol (28:34):I mean, I was blown away. Totally blown away. And this is an era you've really worked on. So can you put it in perspective?Charles Swanton (28:42):Yeah. So we got into this because patients of mine, and many of my colleagues would ask the same question, I've never smoked doctor, I'm healthy. I'm in my mid 50s though they're often female and I've got lung cancer. Why is that doctor? I've had a good diet, I exercise, et cetera. And we didn't really have a very good answer for that, and I don't want to pretend for a minute we solved the whole problem. I think hopefully we've contributed to a little bit of understanding of why this may happen. But that aside, we knew that there were risk factors associated with lung cancer that included air pollution, radon exposure, of course, germline genetics, we mustn't forget very important germline variation. And I think there is evidence that all of them are associated with lung cancer risk in different ways. But we wanted to look at air pollution, particularly because there was an awful lot of evidence, several meta-analysis of over half a million individuals showing very convincingly with highly significant results that increasing PM 2.5 micron particulate levels were associated with increased risk of lung cancer.(29:59):To put that into perspective, where you are on the west coast of the US, it's relatively unpolluted. You would be talking about maybe five micrograms per meter cubed of PM2.5 in a place like San Diego or Western California, assuming there aren't any forest fires of course. And we estimate that that would translate to about, we think it's about one extra case of never smoking lung cancer per hundred thousand of the population per year per one microgram per meter cube rise in the pollution levels. So if you go to Beijing for example, on a bad day, the air pollution levels could be upwards of a hundred micrograms per meter cubed because there are so many coal fired power stations in China partly. And there I think the risk is considerably higher. And that's certainly what we've seen in the meta-analyses in our limited and relatively crude epidemiological analyses to be the case.(30:59):So I think the association was pretty certain, we were very confident from people's prior publications  this was important. But of course, association is not causation. So we took a number of animal models and showed that you could promote lung cancer formation in four different oncogene driven lung cancer models. And then the question is how, does air pollution stimulate mutations, which is what I initially thought it would do or something else. It turns out we don't see a significant increase in exogenous like C to A carcinogenic mutations. So that made us put our thinking caps on. And I said to you earlier, often all these discoveries have been made before. Well, Berenblum in 1947, first postulated that actually tumors are initiated through a two-step process, which we now know involves a sort of pre initiated cell with a mutation in that in itself is not sufficient to cause cancer.(31:58):But on top of that you need an inflammatory stimulus. So the question was then, well, okay, is inflammation working here? And we found that there was an interleukin-1 beta axis. And what happens is that the macrophages come into the lung on pollution exposure, engulf phagocytose the air pollutants, and we think what's happening is the air pollutants are puncturing membranes in the lung. That's what we think is happening. And interleukin-1 beta preformed IL-1 beta is being released into the extracellular matrix and then stimulating pre-initiated cells stem cells like the AT2 cells with an activating EGFR mutation to form a tumor. But the EGFR mutation alone is not sufficient to form tumors. It's only when you have the interleukin-1 beta and the activated mutation that a tumor can start.(32:49):And we found that if we sequence normal lung tissue in a healthy adult 60-year-old adult, we will find about half of biopsies will have an activating KRAS mutation in normal tissue, and about 15% will have an activating mutation in EGFR in histologically normal tissue with nerve and of cancer. In fact, my friend and colleague who's a co-author on the paper, James DeGregori, who you should speak to in Colorado, fascinating evolutionary cancer biologists estimates that in a healthy 60-year-old, there are a hundred billion cells in your body that harbor an oncogenic mutation. So that tells you that at the cellular level, cancer is an incredibly rare event and almost never happens. I mean, our lifetime risk of cancer is perhaps one in two. You covered that beautiful pancreas paper recently where they estimated that there may be 80 to 100 KRAS mutations in a normal adult pancreas, and yet our lifetime risk of pancreas cancer is one in 70. So this tells you that oncogenic mutations are rarely sufficient to drive cancer, so something else must be happening. And in the context of air pollution associated lung cancer, we think that's inflammation driven by these white cells, these myeloid cells, the macrophages.Cancer BiomarkersEric Topol (34:06):No, it makes a lot of sense. And this, you mentioned the pancreas paper and also what's going in the lung, and it seems like we have this burden of all you need is a tipping point and air pollution seems to qualify, and you seem to be really in the process of icing the mechanism. And like I would've thought it was just mutagenic and it's not so simple, right? But that gets me to this is such an important aspect of cancer, the fact that we harbor these kind of preconditions. And would you think that cancer takes decades to actually manifest most cancers, or do we really have an opportunity here to be able to track whether it's through blood or other biomarkers? Another area you've worked on a lot whereby let's say you could define people at risk for polygenic risk scores or various cancers or genome sequencing for predisposition genes, whatever, and you could monitor in the future over the course of those high-risk people, whether they were starting to manifest microscopic malignancy. Do you have any thoughts about how long it takes for the average person to actually manifest a typical cancer?Charles Swanton (35:28):That's a cracking question, and the answer is we've got some clues in various cancers. Peter Campbell would be a good person to speak to. He estimates that some of the earliest steps in renal cancer can occur in adolescence. We've had patients who gave up smoking 30 or so years ago where we can still see the clonal smoking mutations in the trunk of the tumor's evolutionary tree. So the initial footprints of the cancer are made 30 years before the cancer presents. That driver mutation itself may also be a KRAS mutation in a smoking cigarette context, G12C mutation. And those mutations can precede the diagnosis of the disease by decades. So the earliest steps in cancer evolution can occur, we think can precede diagnoses by a long time. So to your point, your question which is, is there an opportunity to intervene? I'm hugely optimistic about this actually, this idea of molecular cancer prevention.An Anti-Inflammatory Drug Reduces Fatal Cancer and Lung Cancer(36:41):How can we use data coming out of various studies in the pancreas, mesothelioma, lung, et cetera to understand the inflammatory responses? I don't think we can do very much about the mutations. The mutations unfortunately are a natural consequence of aging. You and I just sitting here talking for an hour will have accumulated multiple mutations in our bodies over that period, I'm afraid and there's no escaping it. And right now there's not much we can do to eradicate those mutant clones. So if we take that as almost an intractable problem, measuring them is hard enough, eradicating them is even harder. And then we go back to Berenblum in 1947 who said, you need an inflammatory stimulus. Well, could we do something about the inflammation and dampen down the inflammation? And of course, this is why we got so excited about IL-1 beta because of the CANTOS trial, which you may remember in 2017 from Ridker and colleagues showed that anti IL-1 beta used as a mechanism of preventing cardiovascular events was associated with a really impressive dose dependent reduction in new lung cancer primaries.(37:49):Really a beautiful example of cancer prevention in action. And that data weren't just a coincidence. The FDA mandated Novartis to collect the solid tumor data and the P-values are 0.001. I mean it's very highly significant dose dependent reduction in lung cancer incidents associated with anti IL-1 beta. So I think that's really the first clue in my mind that something can be done about this problem. And actually they had five years of follow-up, Eric. So that's something about that intervening period where you can treat and then over time see a reduction in new lung cancers forming. So I definitely think there's a window of opportunity here.Eric Topol (38:31):Well, what you're bringing up is fascinating here because this trial, which was a cardiology trial to try to reduce heart attacks, finds a reduction in cancer, and it's been lost. It's been buried. I mean, no one's using this therapy to prevent cancer between ratcheting up the immune system or decreasing inflammation. We have opportunities that we're not even attempting. Are there any trials that are trying to do this sort of thing?Charles Swanton (39:02):So this is the fundamental problem. Nobody wants to invest in prevention because essentially you are dealing with well individuals. It's like the vaccine challenge all over again. And the problem is you never know who you are benefiting. There's no economic model for it. So pharma just won't touch prevention with a barge pole right now. And that's the problem. There's no economic model for it. And yet the community, all my academic colleagues are crying out saying, this has got to be possible. This has got to be possible. So CRUK are putting together a group of like-minded individuals to see if we can do something here and we're gradually making progress, but it is tough.Eric Topol (39:43):And it's interesting that you bring that up because for GRAIL, one of the multicenter cancer early detection companies, they raised billions of dollars. And in fact, their largest trial is ongoing in the UK, but they haven't really focused on high-risk people. They just took anybody over age 50 or that sort of thing. But that's the only foray to try to reboot how we or make an early microscopic diagnosis of cancer and track people differently. And there's an opportunity there. You've written quite a bit on you and colleagues of the blood markers being able to find a cancer where well before, in fact, I was going to ask you about that is, do you think there's people that are not just having all these mutations every minute, every hour, but that are starting to have the early seeds of cancer, but because their immune system then subsequently kicks in that they basically kind of quash it for that period of time?Charles Swanton (40:47):Yeah, I do think that, I mean, the very fact that we see these sort of footprints in the tumor genome of immune evasion tells you that the immune system's having a very profound predatory effect on evolving tumors. So I do think it's very likely that there are tumors occurring that are suppressed by the immune system. There is a clear signature, a signal of negative selection in tumors where clones have been purified during their evolution by the immune system. So I think there's pretty strong evidence for that now. Obviously, it's very difficult to prove something existed when it doesn't now exist, but there absolutely is evidence for that. I think it raises the interesting question of immune system recognizes mutations and our bodies are replete with mutations as we were just discussing. Why is it that we're not just a sort of epithelial lining of autoimmunity with T-cells and immune cells everywhere? And I think what the clever thing about the immune system is it's evolved to target antigens only when they get above a certain burden. Otherwise, I think our epithelial lining, our skin, our guts, all of our tissues will be just full of T-cells eating away our normal clones.(42:09):These have to get to a certain size for antigen to be presented at a certain level for the immune system to recognize it. And it's only then that you get the immune predation occurring.Forever Chemicals and Microplastics Eric Topol (42:20):Yeah, well, I mean this is opportunities galore here. I also wanted to extend the air pollution story a bit. Obviously, we talked about particulate matter and there's ozone and nitric NO2, and there's all sorts of other air pollutants, but then there's also in the air and water these forever chemicals PFAS for abbreviation, and they seem to be incriminated like air pollution. Can you comment about that?Charles Swanton (42:55):Well, I can comment only insofar as to say I'm worried about the situation. Indeed, I'm worried about microplastics actually, and you actually cover that story as well in the New England Journal, the association of microplastics with plaque rupture and atheroma. And indeed, just as in parenthesis, I wanted to just quickly say we currently think the same mechanisms that are driving lung cancer are probably responsible for atheroma and possibly even neurodegenerative disease. And essentially it all comes down to the macrophages and the microglia becoming clogged up with these pollutants or environmental particulars and releasing chronic inflammatory mediators that ultimately lead to disease. And IL-1 beta being one of those in atheroma and probably IL-6 and TNF in neurodegenerative disease and what have you. But I think this issue that you rightly bring up of what is in our environment and how does it cause pathology is really something that epidemiologists have spent a lot of time focusing on.(43:56):But actually in terms of trying to move from association to causation, we've been, I would argue a little bit slow biologically in trying to understand these issues. And I think that is a concern. I mean, to give you an example, Allan Balmain, who works at UCSF quite close to you, published a paper in 2020 showing that 17 out of 20 environmental carcinogens IARC carcinogens class one carcinogens cause tumors in rodent models without driving mutations. So if you take that to a logical conclusion, in my mind, what worries me is that many of the sort of carcinogen assays are based on driving mutagenesis genome instability. But if many carcinogen aren't driving DNA mutagenesis but are still driving cancer, how are they doing it? And do we actually have the right assays to interpret safety of new chemical matter that's being introduced into our environment, these long-lived particles that we're breathing in plastics, pollutants, you name it, until we have the right biological assays, deeming something to be safe I think is tricky.Eric Topol (45:11):Absolutely. And I share your concerns on the nanoplastic microplastic story, as you well know, not only have they been seen in arteries that are inflamed and in blood clots and in various tissues, have they been seen so far or even looked for within tumor tissue?Charles Swanton (45:33):Good question. I'm not sure they have. I need to check. What I can tell you is we've been doing some experiments in the lab with fluorescent microplastics, 2.5 micron microplastics given inhaled microplastics. We find them in every mouse organ a week after. And these pollutants even get through into the brain through the olfactory bulb we think.Charles Swanton (45:57):Permeate every tissue, Eric.Eric Topol (45:59):Yeah, no, this is scary because here we are, we have these potentially ingenious ways to prevent cancer in the future, but we're chasing our tails by not doing anything to deal with our environment.Charles Swanton (46:11):I think that's right. I totally agree. Yeah.Eric Topol (46:15):So I mean, I can talk to you for the rest of the day, but I do want to end up with a topic that we have mutual interest in, which is AI. And also along with that, when you mentioned about aging, I'd like to get your views on these two, how do you see AI fitting into the future of cancer? And then the more general topic is, can we actually at some point modulate the biologic aging process with or without help with from AI? So those are two very dense questions, but maybe you can take us through them.Charles Swanton (46:57):How long have we got?Eric Topol (46:59):Just however long you have.A.I. and CancerCharles Swanton (47:02):AI and cancer. Well, AI and medicine actually in general, whether it's biomedical research or medical care, has just infinite potential. And I'm very, very excited about it. I think what excites me about AI is it's almost the infinite possibilities to work across scale. Some of the challenges we raised in the Cell review that you mentioned, tackling, embracing complexity are perfectly suited for an AI problem. Nonlinear data working, for instance in our fields with CT imaging, MRI imaging, clinical outcome data, blood parameters, genomics, transcriptomes and proteomes and trying to relate this all into something that's understandable that relates to risk of disease or potential identification of a new drug target, for example. There are numerous publications that you and others have covered that allude to the incredible possibilities there that are leading to, for instance, the new identification of drug targets. I mean, Eli Van Allen's published some beautiful work here and in the context of prostate cancer with MDM4 and FGF receptor molecules being intimately related to disease biology.(48:18):But then it's not just that, not just drug target identification, it's also going all the way through to the clinic through drug discovery. It's how you get these small molecules to interact with oncogenic proteins and to inhibit them. And there are some really spectacular developments going on in, for instance, time resolved cryo-electron microscopy, where in combination with modeling and quantum computing and what have you, you can start to find pockets emerging in mutant proteins, but not the wild type ones that are druggable. And then you can use sort of synthetic AI driven libraries to find small molecules that will be predicted to bind these transiently emerging pockets. So it's almost like AI is primed to help at every stage in scientific investigation from the bench all the way through to the bedside. And there are examples all the way through there in the literature that you and others have covered in the last few years. So I could not be more excited about that.Eric Topol (49:29):I couldn't agree with you more. And I think when we get to multimodal AI at the individual level across all their risks for conditions in their future, I hope someday will fulfill that fantasy of primary prevention. And that is getting me to this point that I touched on because I do think they interact to some degree AI and then will we ever be able to have an impact on aging? Most people conflate this because what we've been talking about throughout the hour has been age-related diseases, that is cancer, for example, and cardiovascular and neurodegenerative, which is different than changing aging per se, body wide aging. Do you think we'll ever changed body wide aging?Charles Swanton (50:18):Wow, what a question. Well, if you'd asked me 10 years ago, 15 years ago, do you think we'll ever cure melanoma in my lifetime, I'd have said definitely not. And now look where we are. Half of patients with melanoma, advanced melanoma, even with brain metastasis curd with combination checkpoint therapy. So I never say never in biology anymore. It always comes back to bite you and prove you wrong. So I think it's perfectly possible.Charles Swanton (50:49):We have ways to slow down the aging process. I guess the question is what will be the consequences of that?Eric Topol (50:55):That's what I was going to ask you, because all these things like epigenetic reprogramming and senolytic drugs, and they seem to at least pose some risk for cancer.Charles Swanton (51:09):That's the problem. This is an evolutionary phenomenon. It's a sort of biological response to the onslaught of these malignant cells that are potentially occurring every day in our normal tissue. And so, by tackling one problem, do we create another? And I think that's going to be the big challenge over the next 50 years.Eric Topol (51:31):Yeah, and I think your point about the multi-decade challenge, because if you can promote healthy aging without any risk of cancer, that would be great. But if the tradeoff is close, it's not going to be very favorable. That seems to be the main liability of modulation aging through many of the, there's many shots on goal here, of course, as you well know. But they do seem to pose that risk in general.Charles Swanton (51:58):I think that's right. I think the other thing is, I still find, I don't know if you agree with me, but it is an immense conundrum. What is the underlying molecular basis for somatic aging, for aging of normal tissues? And it may be multifactorial, it may not be just one answer to that question. And different tissues may age in different ways. I don't know. It's a fascinating area of biology, but I think it really needs to be studied more because as you say, it underpins all of these diseases we've been talking about today, cardiovascular, neurodegeneration, cancer, you name it. We absolutely have to understand this. And actually, the more I work in cancer, the more I feel like actually what I'm working on is aging.(52:48):And this is something that James DeGregori and I have discussed a lot. There's an observation that in medicine around patients with alpha-1 antitrypsin deficiency who are at higher risk of lung cancer, but they're also at high risk of COPD, and we know the associations of chronic obstructive pulmonary disease with lung cancer risk. And one of the theories that James had, and I think this is a beautiful idea, actually, is as our tissues age, and COPD is a reflection of aging, to some extent gone wrong. And as our tissues age, they become less good at controlling the expansion of these premalignant clones, harboring, harboring oncogenic mutations in normal tissue. And as those premalignant clones expand, the substrate for evolution also expands. So there's more likely to be a second and third hit genetically. So it may be by disrupting the extracellular matrices through inflammation that triggers COPD through alpha-1 antitrypsin deficiency or smoking, et cetera, you are less effectively controlling these emergent clones that just expand with age, which I think is a fascinating idea actually.Eric Topol (54:01):It really is. Well, I want to tell you, Charlie, this has been the most fascinating, exhilarating discussion I've ever had on cancer. I mean, really, I am indebted to you because not just all the work you've done, but your ability to really express it, articulate it in a way that hopefully everyone can understand who's listening or reading the transcript. So we'll keep following what you're doing because you're doing a lot of stuff. I can't thank you enough for joining me today, and you've given me lots of things to think about. I hope the people that are listening or reading feel the same way. I mean, this has been so mind bending in many respects. We're indebted to you.Charles Swanton (54:49):Well, we all love reading your Twitter feeds. Keep them coming. It helps us keep a broader view of medicine and biological research, not just cancer, which is why I love it so much.******************************************The Ground Truths newsletters and podcasts are all free, open-access, without ads.Please share this post/podcast with your friends and network if you found it informativeVoluntary paid subscriptions all go to support Scripps Research. Many thanks for that—they greatly helped fund our summer internship programs for 2023 and 2024.Thanks to my producer Jessica Nguyen and Sinjun Balabanoff tor audio and video support at Scripps Research.Note: you can select preferences to receive emails about newsletters, podcasts, or all I don't want to bother you with an email for content that you're not interested in. Get full access to Ground Truths at erictopol.substack.com/subscribe

Let us know what you think - text the show!On this week's show:Happy National Bourbon day, New Mexico day, and Pet wedding weekBennington lawmaker caught harassing colleagueBurlington mayor defends getting free meals from citizensPhil Scott signs animal cruelty lawCows in electric collarsSunCommon goes belly upBad news for lumber industry? Accounting error brings Burlington budget gap to $14.1M (55:26) Break music: Dead Street Dreamers- “Dark Thoughts”https://deadstreetdreamers.bandcamp.com/track/dark-thoughts Colchester Causeway now under state ownership  Political sign beef and do these things even work?Vermont Supreme Court takes away whistleblower award Concession stand coming to Burlington's City Hall Park  Wallingford considers making ballfield constable more visible Milton HS BLM art vandalizedPride flag stolenCabot poetry trail(1:42:52)  Break music: The Chloe Brisson Band - “No Savior”https://chloelouisebrisson.bandcamp.com/track/no-savior Scumbag Map  Man flees three crashes in one day Vt. woman serving time for attempted murder accused of attacking cellmate  Bennington man held without bail after violent incident Plainfield parts dealer admits to fraud Officer involved shooting in Orange, VT Whatchu know bout Orange, VT? The Reverse Goldilocks: Bear gets comfy on a hammockThanks for listening!Follow us on Facebook: facebook.com/VermontCatchup Follow Matt on twitter: @MatthewBorden4 Contact the show: 24theroadshow@gmail.comIOutro Music by B-Complex

Let us know what you think - text the show!On this week's show:Happy National VCR DayBennington County Senator Dick Sears has died at 81 - VTDiggerBurlington cops scare high schoolers w/ fake shootingVermont ACLU takes Essex County Sheriff's Department to court in public VT Christian Alliance allege they are discriminated against due to LGBTQ protections for foster kidsBeta reports full test flight of vertical takeoff prototype Wreck of 1971 plane crash discovered in Lake Champlain 84-year-old man rescued from glider crash25K Vermonters lose internetBurlington repeat offender takes plea deal on federal robbery charges I-89 study focuses on South Burlington exit (1:00:07) Break music: Kate Kush - “False Cry”https://katekushmusic.bandcamp.com/track/false-cry Burlington garden club honors found member with benchA Developer's Storm Cleanup Crossed Into a Burlington ParkArchaeological dig at old psychiatric hospitalVermont reports lowest fertility rate in the US amid national decline -Topsham student sues after denied scholarshipCostco hot  dog price stays firm Darn Tough is wrestling with ‘rampant' social media  scams.(2:00:53)  Break music: FOZ - “Sense of Imperfection”https://foz-music.bandcamp.com/track/sense-of-imperfection  Scumbag Map Lawnmower thiefSerial Killer - thousands of remains Shelburne drug traffickingDeadly police chase through Colchester Stolen dump truckWallingford man seriously beatenHigh-speed chase ends in crash, driver threatens police with hammer  Breakfast sandwich thief in Saint AlbansBear freed from stuck jugThanks for listening!Follow us on Facebook: facebook.com/VermontCatchup Follow Matt on twitter: @MatthewBorden4 Contact the show: 24theroadshow@gmail.comIOutro Music by B-Complex

Let us know what you think - text the show!On this week's show:Happy national dinosaur dayWhy am I so happy that Trump was convicted?Negro league baseball recordsWhat does passage of Vt. psychedelic mushroom law mean? The Rosa parks of being stoned at workBurlington Mayor Emma Mulvaney-Stanak reappoints Jon Murad as police chief US Supreme Court could take up South Burlington land use case Colleagues call death of Mazza the end of an eraWindham school district in crisisSome Burlington City Council members not aware of plan to support waterfront  homeless camp Plans to convert Burlington YMCA into housing hit a snagVT bought an island(1:01:43) Break music: HASKELL - “Let Me In”https://haskellsucks.bandcamp.com/track/let-me-in Townshend veteran finally honored by FranceVt. becomes 1st state requiring oil companies to pay for damage from climate Barriers meant to prevent truck stuckages at Smugglers Notch get tested rightCommunity pushes back on Goddard College campus buyer A reason to watch women's Olympic rugbyA Group of Burlington Neighbors Is Painting Over Graffiti Themselves Unearthed by accident: a plant lost to Vermont for a century is discovered VT spelling champ headed to DC & Update VT 3rd best state to learn to ride a bike(1:50:42)  Break music: WiseAcres - “Adjust the Angles”https://wiseacres.bandcamp.com/track/adjust-the-angles Scumbag Map 42-year-old homicide solved Danby Walmart shootingNorthfield Kristal goes on rampageSaint Albans crime blotterVt. police say chronic littering culprit caught, fined Thanks for listening!Follow us on Facebook: facebook.com/VermontCatchup Follow Matt on twitter: @MatthewBorden4 Contact the show: 24theroadshow@gmail.comIOutro Music by B-Complex

Let us know what you think - text the show!On this week's show:Happy Brother's DayIts hot AFPhil Scott hates beesHoward Dean, Miro Weinberger rule out runs for governor of Vermont Trend? The olds are retiringTenant protections failUVM halts construction of housingVt. officials say $1M Lake Carmi aeration system made water quality VT Search and Rescues are risingThe Circus Smirkus guy has a memoirDoes Burlington ha ve too many cannabis shops?(59:47) Break music: Fattie B - "Too Complex"https://equaleyesrecords.bandcamp.com/album/lo-fi-foolishness-dated-references-collaborations-creations-1994-til-now Dozens of layoffs at former Vermont Teddy Bear distribution center due to  Dude jumps off 89 overpass, livesNorth hero - Grand Isle bridge stuck upThe Harlem Wizards?The “Play Every Town Project” Alleys project underwayOnce Off-Limits, Burlington's Rock Point Is Gradually Welcoming the Public  Castleton library gets an elevator How many fire trucks does Castleton need? Whatchu know ‘bout Castleton, VT?VT's first black restaurant owner is honored(1:47:39)  Break music: Watercoat - "With or Without"https://watercoat.bandcamp.com/album/circles-on-my-map Scumbag Map Iowa Woman Fraud Milton man arrested for voyeurism Rutland man tries to escape probation officeRandom punching Burlington robbery at gunpoint Would be pipe-bomber gets 6 yearsBurlington man accused of assaulting police officer  We got a biter! A civilized scumbag - Hartland break-inInvasive  beetles on Burlington beachThanks for listening!Follow us on Facebook: facebook.com/VermontCatchup Follow Matt on twitter: @MatthewBorden4 Contact the show: 24theroadshow@gmail.comIOutro Music by B-Complex

Text Matt & Adam!We're back with the theme "the movie process". Many people consider "8 1/2" (1963) to be  Fellini's masterpiece. A movie director tries to figure out  his next project. What's a dream? What's real? Sometimes were not sure. "Black Bear" (2020)  stars Aubrey Plaza as woman film maker trying break her creative roadblock. The first thirty minutes of the film is a little slow, but the last hour is so good, that it makes the first part so much better. Definitely worth checking out.Next up, Matt introduces Adam to indie director Hal Hartley with "Trust" (1990) & "Simple Men" (1992).Have your own recommendations? Contact the show:24theroadshow@gmail.com

Let us know what you think - text the show!On this week's show:Happy National “Shades” DayNo one wants to be the racial equity directorBurlington mayor seeks to reduce graffiti problem Meet your next governor, Poa MutinoMan accused of killing gf says not enough evidenceWhatchu know ‘bout Searsburg, VT?Women's prison proposal too bigWe got our weathervane backVeteran broadcaster Stewart Ledbetter to run for Vermont Senate (36:54) Break music: The Funky Flats - “Play the Fool”https://thefunkyflats.bandcamp.com/track/play-the-fool Notch Road barriers fail to stop tractor-trailerVT master sculptor wins a webby VT team heading to national drone championships Sip & Shop returns to RutlandNew chef at Starry Night cafeWe're getting jamaican cuisineBrattleboro granola business for sale(1:20:46)  Break music: Gas Station Dog Exchange - “Air”https://gsde.bandcamp.com/track/air Scumbag Map  2 wrong-way drivers stopped on Vt. interstates, police say Ex-corrections officer charged for smuggling tobacco into Rutland prisonSaint Albans woman arrested for restaurant theftsPolice say masked man killed in St. Johnsbury died from gunshot wounds to his VT man shoots at occupied homeDerby Line man held without bail after domestic assault, resisting arrest  Former Vermont man charged for alleged role in death of James ‘Whitey' Bulger Stay alert for turtlesThanks for listening!Follow us on Facebook: facebook.com/VermontCatchup Follow Matt on twitter: @MatthewBorden4 Contact the show: 24theroadshow@gmail.comIOutro Music by B-Complex

Let us know what you think - text the show!On this week's show:Happy National “One Day Without Shoes” DaySanders, 82, cites Trump, nation's problems in reelection bid (wcax.com)Phil Scott appoints a demRoxbury junk ordinanceWhatchu know ‘bout Roxbury, VT?Cannabis Company Could Lose License for Using Banned Pesticide Vermont opioid deaths decline for the first time since 2019,Birdman Bike Lawmakers at odds over retail theft billMilton Inclusion FestivalFilm about tragic Vermont farmerPlainfield Co-op to Move to Plainfield Hardware (1:03:59) Break music: Raw Deff & Rico James - “Gung Ho”https://rawdeffandricojames.bandcamp.com/track/gung-ho  Burlington tries to quell annual student move out mess Bitcoin ATMs Breakfast-gate in Barre Shady Mendon motel owner promises not to be shadyVt. police seek ‘artist' behind vandalism in playful social media post Save the St Albans clock towerBurlington businesses say construction hurts businessNew Marker Provides History of Battery ParkVermont Reptile and Amphibian Atlas turns 30  (2:04:28)  Break music: silence_Castor - “Elsewhere”https://silencecastor.bandcamp.com/track/elsewhere Scumbag Map  Suspicious deaths in South HeroNH fugitive found in Warren Colchester man convicted for role in killing of drug rivalWindham strangler Sex assault in BarreBurlington man busted in perv sting Saint Albans police blotter Attempted murder in Kirby, VT Lamb history made in VT Chinese dye dogsThanks for listening!Follow us on Facebook: facebook.com/VermontCatchup Follow Matt on twitter: @MatthewBorden4 Contact the show: 24theroadshow@gmail.comIOutro Music by B-Complex

Let us know what you think - text the show!On this week's show:Happy National No Pants DayAnother Howard Dean run? Scott doubles downFrozen pizza recall900% increase in blood disease at UVM MCDo nurses know how much other people make?Dental hygienist shortage Report: Burlington offers just ‘adequate' nature space Vermont road crews navigate multiple mud seasons Killington wants to expand Rabies vaccine bait drops to begin this weekend  The Crazy Contraption Camp (1:03:59) Break music: Tabarnak - “The Bark”https://tanarnak.bandcamp.com/track/the-bark We lost another diner - Betsy's Dot The future of fertilizer? Pee, says this Brattleboro institute Pretty girl problems - former Miss Vermont kicked out of AirBnB for being too hot Scowling Brandon woman named poet laureate Cannabis as a home businessNo political events on playgrounds Contact-less parkingBurlington library getting shady A more inclusive school calendarVergennes mayor confirms city picked to host juvenile justice facility 6th grader inspires Enosburgh dog park (2:04:28)  Break music: Terry Donahue - “Stumblin' In”https://terrydonahue.bandcamp.com/track/stumblin-in Scumbag Map  Men in Orleans cited after fight over loose pigs Milton man hit & runFormer Bristol man gets 18 years in prison for plotting with mother to kill his ste Ortiz gets 7 years for leading drug ring in Orleans County -  Newport wild ride Saint Albans cocaine charges Fairfield grand larceny Tennesse e groper in BerlinThanks for listening!Follow us on Facebook: facebook.com/VermontCatchup Follow Matt on twitter: @MatthewBorden4 Contact the show: 24theroadshow@gmail.comIOutro Music by B-Complex

On this week's show:Happy National take your pick dayBurlesque dayHug an Australian dayYour first kiss dayBirdhouse vandalState Sen Bobby Starr retiresEx-Norwich University president sued over inappropriate behaviorThe future of downtown Brattleboro uncertainBarre to Sell Two Parking Lots for $1 to Housing Developer Barn preservation grantsAirport taxi rate Vermont confirms first measles case since 2018 Impacts of Vermont's single-use plastic ban, 4 years later  Best beard in VTBruins fan goes viral w/ maple syrup sign(53:22) Break music: The Champlain Shoregasm - “As the World Comes Apart”https://thechamplainshoregasm.bandcamp.com/track/as-the-world-comes-apart  Tree planting beef in Charlotte Timbersports coming to Maplefest Street sweeping season in BurlingtonNorwich Olympic rowerMarshfield couple spreads sunflower seeds for Ukraine Bradford  restaurant finedTanya Sousa debuts new children's book ‘Rescued' at Newport, Lyndon libraries Morrisville needs a bridge trollVTrans to install obstacles to prevent stuck trucks on Notch Road  Animal communicatorVt. sheriff's deputy who caused mistrial loses job (1:33:05)  Break music: Yann Falquet - “Du long de la mer joile” (Along the pretty sea) https://yannfalquet.bandcamp.com/track/du-long-de-la-mer-jolie Scumbag Map Drugs and guns in BarreCops arrest man accused of choking, knife threat Rutland man charged with taking photos of girlRutland stabbingBurlington machete attackTwo arrested after defecating in victim's car during Barton-Lowell crime spree - Newport DispatchShots fired in JaySaint J BB gun bandit Montpelier police logNewport man faces federal gun charges  Would be ATM heist in East Wallingford, VT Bald eagles vs blue herons Winners of pet photo contestThanks for listening!Follow us on Facebook: facebook.com/VermontCatchup Follow Matt on twitter: @MatthewBorden4 Contact the show: 24theroadshow@gmail.comIOutro Music by B-Complex

Back from their internships at the Parallax Corporation, Matt and Adam have a couple paranoia thrillers this week. Z (1969) is the realistic portrayal of a progressive politician who ends on the wrong end of a club. Fascism, mob violence, a political cover-up? That would never happen today.... In The Parallax View (1974), we meet a mysterious corporation up to no good (29:30). Warren Beatty does his best, but we just don't like him. Have your own recommendations? Contact the show:24theroadshow@gmail.com

On this week's show:Happy National Pizza Delivery Driver Appreciation DayJoe's Pond officially iced out early Sunday morning  + Danville man winnerWarning: ‘Cicada-geddon' is only a month away (wcax.com)Vermont's elderly workforce Restaurant owners say Burlington police failed to respond during vandalismER visits increase due to e-bikesFatal car crashes finally trending downWelch sighting - he's a real Senator, y'allFinally, a new kid prison in Vergennes VT data privacy bill unlikelyManchester vampire(56:49) Break music: Sleepy Spectre - “Tumble Bus”https://gatchi.bandcamp.com/track/tumble-bus-feat-john-francy-windross95 Alzheimer's memory cafes are popping upNew Miss Vermont crownedCastleton University sex assault art installmentWeightlifters set state recordAn alley is getting revitalized in Waterbury Panton is getting a big-ass solar arrayWe missed a momo eating contest Brattleboro art smash partyEssex flea marketMystery cash in Winooski(1:48:36)  Break music: Bergadler - “Solid Veronica”https://bergadler.bandcamp.com/album/solid-veronica Scumbag MapVt. police arrest teen in connection with multiple homicides Hardwick man gets knife pulled on him by passenger Derby gun thief Whatchu know ‘bout Derby, VT? Saint albans RV arsonist Thieves target convenience stores for vapes Kid thrown out of truck Alleged dog feces flinger Thanks for listening!Follow us on Facebook: facebook.com/VermontCatchup Follow Matt on twitter: @MatthewBorden4 Contact the show: 24theroadshow@gmail.comIOutro Music by B-Complex

On this week's show:Happy International Licorice Day160K people drove to the state for Monday's eclipse Private planes packed BTVTrain hits car in BartonBernie Sanders arsonistDick Mazza resignsGoddard College to close after 86 yearsNo impeachment for nut-kicking sheriffWheeler park development goes to trialWould you drink Luiz Guzman's Jus?(50:33) Break music: Ben Roque - “Charmed I'm Sure”https://benroque.bandcamp.com/album/mad-andalusia UVM hair equity programWork underway on Community Sailing Center in Burlington Rutland robotics team headed to Houston  Over 1,200 Vt. contractors have signed up for mandatory registry Swanton mom baby touches tussock moth cocoon Ethics Panel Dismisses Complaint Against Ram Hinsdale VAST reports bad winter for snowmobiling Putney fire department quitsSugar Mountain buys Whetstone craft brewery facility(1:32:54)  Break music: Until We're Dead and Gone - “Everybody's Out to Get Me”https://untilweredeadandgone.bandcamp.com/album/burn Scumbag MapBurglar steals from 5-year-oldPolice hunt for Massachusetts teen in Pownal murder Police: Wi-Fi jammer aided burglars Cocaine charges mount for womanNewport man charged with second degree domestic assault A bunch of DUIs and wrong-way driversThanks for listening!Follow us on Facebook: facebook.com/VermontCatchup Follow Matt on twitter: @MatthewBorden4 Contact the show: 24theroadshow@gmail.comIntro/Outro Music by B-Complex

Investigation underway after a shooting in Swanton, outside of Toledo; historic church in Cleveland destroyed by fire; AEP planning a rate hike next month; both of Ohio's MLB teams had victorious opening days.

Laura Swanton-Rouvelin - Winter Downs 200 Champion - Episode 57Precision Fuel & Hydration helps athletes personalise their hydration and fueling strategies for training and racing. Use the free Fuel & Hydration Planner to get a personalized race nutrition plan for your next event. Tea And Trails Podcast listeners get 15% off their first order of fuel and electrolytes with Precision Fuel & Hydration. Use this link and the discount will be auto-applied at the checkout.Trail runner interview, training advice, nutrition advice and kit reviews too. We'll talk about current trail running stories and stories from inspirational people we feel you might be interested in. If you like what we do, then please tell your friends.This week we catch up with Winter Downs 200 Champion,  Laura Swanton-Rouvelin.  We chatted about all things Winter Downs 200. Also, potential future races too!We share our deets, pop over to Strava, Patreon Lee Caves has a question about pacing a race like the SILVA Northern Traverse and share your Tales from the Trails.YouTube Reviewshttps://www.youtube.com/@GaryThwaitesBrew with the coaches - Thanks, Trish, Rebecca and Russell!Brew with the Coaches - https://www.teaandtrails.com/coachesSupport the showAmazon links are affiliate links.Celeste Yvonne's Book - https://amzn.to/40FYLK9Fix Your Feet Book - https://amzn.to/3FE4nf0Microphone - https://amzn.to/3huN86KGary's BGR Headtorch - https://amzn.to/3DQkoO2Eddie's Spine Race Headtorch - https://amzn.to/40pFXhgROAR - https://amzn.to/3WU7xB2NEXT LEVEL - https://amzn.to/3Hu15LrThe Daily Stoic Book - https://amzn.to/44qDm9jUltra Trails - https://www.ultratrails.co.uk/Greener Miles Running - https://greenermilesrunning.co.uk/Dales Runner - https://dalesrunner.co.uk/Hannah Walsh CoachSupport the showAmazon links are affiliate links.Celeste Yvonne's Book - https://amzn.to/40FYLK9Fix Your Feet Book - https://amzn.to/3FE4nf0Microphone - https://amzn.to/3huN86KGary's BGR Headtorch - https://amzn.to/3DQkoO2Eddie's Spine Race Headtorch - https://amzn.to/40pFXhgROAR - https://amzn.to/3WU7xB2NEXT LEVEL - https://amzn.to/3Hu15LrThe Daily Stoic Book - https://amzn.to/44qDm9jUltra Trails - https://www.ultratrails.co.uk/Greener Miles Running - https://greenermilesrunning.co.uk/Dales Runner - https://dalesrunner.co.uk/Hannah Walsh Coaching - https://www.hannahwalsh.co.uk/Punk Panther - https://www.punkpanther.co.uk/

We're back with a couple lesser known Philip Seymour Hoffman films. Owning Mahoney (2003) was Hoffman's first starring role. Based on a true story about a Toronto banker who steals millions to support his gambling habit.  Sidney Lumet's "Before the Devil Knows Your Dead" (2007) is a must see. The story of two brothers robbing their parents jewelry store. Next, mothers going insane with John Cassevetes,' "Woman Under the Influence" (1974) and from "Parasite" director Boon Joon Ho, "Mother" (2009).Have your own recommendations? Contact the show:24theroadshow@gmail.com

Dominic is joined by the inimitable James Swanton  who is performing A Christmas Carol, The Chimes and Haunted Man in person this year at the Dickens Museum. And for those of you listening outside the UK you can watch a live stream of his Haunted Man - filmed inside number 48 Doughty Street - on the 11th December.James read English at Selwyn College Cambridge. Since graduating his acting credits include Sikes and Nancy at London's Trafalgar Studios, Irving Undead and this years' upcoming BBC Ghost Story for Christmas Lot No.249His inspirations are far ranging, and a brilliant English teacher by the name of Mr Crisp who took James under his wing when he was at secondary school and set him on the path that he still treads today … Support the showIf you like to make a donation to support the costs of producing this series you can buy 'coffees' right here https://www.buymeacoffee.com/dominicgerrardHost: Dominic GerrardSeries Artwork: Léna GibertOriginal Music: Dominic GerrardThank you for listening!

Welcome, lovely mamas, to another nourishing episode of "The Happy Mama Movement Podcast." Today we're diving deep into a conversation that may very well transform the way you see yourself, your body, and your journey through motherhood.In this episode, we have the pleasure of chatting with the remarkable Hollie Swanton. Hollie is a Women's Health Occupational Therapist, Yoga Teacher and Mama Rising Facilitator. Hollie provides integrated mind-body support to women across the lifespan, with a special interest in the perinatal period, as they embark on navigating potent changes to their body, emotions, senses, environment (internally and externally), roles and routines.Hollie supports women to track their nervous system, feelings and sensations in their bodies internally, so they can use meaningful action and agency in their lives externally. Together, we explore the profound relationship between motherhood, self-identity, and the physical vessel we inhabit. Hollie's insights are a beacon of light, reminding us that our bodies are not just vessels but sources of knowledge and intuition.We delve into the transformative journey of self-understanding, the power of reclaiming our bodies after childbirth, and the magic that unfolds when we connect with our inner selves. Hollie's wisdom shines through as she guides us on a path of self-compassion and nurturing that every mama deserves to experience, introducing us to the Psycho-sensory world that has been right under our noses all along, which might just help you explain some of your most puzzling behaviors.So, grab your favorite drink, find a cozy spot, and let's embark on this enlightening conversation with Hollie. It's a journey of self-discovery, body wisdom, and empowerment that you won't want to miss.I'm so glad you're here with us.-------------------------------------------------------------------------------------WATCH THE FULL AUDIO/ VISUAL VERSION HERE: https://youtu.be/sDJX-Ql6Ocg-------------------------------------------------------------------------------------FIND OUT MORE ABOUT HOLLIE:Hollie provides both 1:1 services via telehealth and in-person sessions in Cairns, Far North Queensland. As a Mental health-endorsed Occupational Therapist, Hollie is able to provide subsidized support covered in part by Medicare in Australia. Hollie provides workshops and yoga/connection classes to experience mindfulness and 'bodyfulness'. Hollie is available for support both online and in person.www.hollieswanton.com.auInstagram @hollieswanton_otthegatheringplace.au-------------------------------------------------------------------------------------Please visit my website: https://www.amytaylorkabbaz.com and: https://mamarising.net/ to submit questions for Mama Q, our new Q&A podcast session, where we answer your questions regarding Matrescence and motherhood------------------------------------------------------------------------------------WOULD YOU LIKE TO KNOW...-How motherhood changes your core identity-What the 'Inner Split' is, and how to come to terms with this change within you-How to stop being torn between all the roles you have to play-How to see yourself, your body, and all your relationships differently-How to stop being so hard on yourself and, in turn, stop being so resentful towards...

Garrett and Liam are back to talk all things TNA up to Bound For Glory 2005 - including the first month on Spike TV, Team 3D's debut, Kevin Nash's return and subsequent pulling out of Bound For Glory, Rhino's World Title win, TNA's ratings success, WWE's petty battles with Spike, Jerry Jarrett visiting WWE, Jeff Hardy's biggest Swanton, Jushin Liger's TNA debut, Iron Man 2, the Team 3D funeral and so much more.Support us on Patreon for more audio content, show notes, star ratings and more: https://www.patreon.com/KiddingMeFollow us on Twitter: https://twitter.com/TNAHistoryPodAdvertising Inquiries: https://redcircle.com/brandsPrivacy & Opt-Out: https://redcircle.com/privacy