Podcasts about type two diabetes

Dr. Hoffman continues his conversation with Dr. Jacob Teitelbaum, Integrative Medicine physician, researcher, and best-selling author.

Diabetes Deep Dive: Dr. Jacob Teitelbaum, an integrative medicine physician and author, discusses diabetes from a multifaceted perspective. They explore the connections between diabetes, chronic fatigue syndrome, fibromyalgia, sleep disorders, metabolic syndrome, and long COVID. Dr. Teitelbaum offers insights into the historical emergence of diabetes in correlation with lifestyle and dietary changes, particularly the Western diet's high sugar and low fiber content. They discuss the roles of vitamin D, magnesium, and other nutrients, as well as the impact of chemicals on metabolism. The conversation also covers the importance of sleep, stress management, and lifestyle adjustments. Dr. Teitelbaum recommends natural supplements like Sucontral D, berberine, and melatonin to manage blood sugar levels effectively. The episode concludes with a discussion on the controversial role of pharmaceutical interventions like GLP-1 drugs and insulin. Dr. Teitelbaum emphasizes a balanced, integrative approach that empowers self-care and holistic health management.

What's the deal with statin drugs and “high cholesterol”? Even doctors are starting to raise questions. They say that “high cholesterol” is anything over 200 total, but where does this number come from? Is there evidence that cholesterol over 200 actually leads to heart disease? Why do we need cholesterol, and is it possible for it to get too low? On this episode of Vitality Radio Jared arms you with the information you need to decide what to do, if anything, about your “high” cholesterol.  Pharmaceutical companies often develop drugs that target specific symptoms by interfering with the body's natural processes. These medications can be effective in providing temporary relief from symptoms, but they don't usually address the underlying causes of a condition. This is called suppressive medicine, and such treatments may offer short-term benefits at the cost of long-term health. In this series of episodes on suppressive medicine, Jared aims to help you understand the ways in which these drugs work and what natural alternatives there are that work WITH your body's natural systems to address the root cause and rebalance the body. Products:BerberineAdditional Information:#332: Cholesterol Controversy - Jared's Interview on Inside The Aisle with Niki WolfeVisit the podcast website here: VitalityRadio.comYou can follow @vitalityradio and @vitalitynutritionbountiful on Instagram, or Vitality Radio and Vitality Nutrition on Facebook. Join us also in the Vitality Radio Podcast Listener Community on Facebook. Shop the products that Jared mentions at vitalitynutrition.com. Let us know your thoughts about this episode using the hashtag #vitalityradio and please rate and review us on Apple Podcasts. Thank you!Please also join us on the Dearly Discarded Podcast with Jared St. Clair.Just a reminder that this podcast is for educational purposes only. The FDA has not evaluated the podcast. The information is not intended to diagnose, treat, cure, or prevent any disease. The advice given is not intended to replace the advice of your medical professional.

In this episode, Melissa delves into prediabetes, metabolic syndrome, and type 2 diabetes, discussing their prevalence, risks, and the importance of early detection. She emphasizes lifestyle modifications like healthy eating, regular exercise, and stress management. Melissa highlights the role of healthcare professionals in managing these conditions and mentions dietary recommendations and supplements such as berberine and alpha lipoic acid, cautioning to consult healthcare providers before making changes. She underscores the significance of proactive health management and collaboration with medical experts to prevent serious complications.   Resources from this episode: Sign Up To Work With Melissa   Sign Up To Be A Guest On The Podcast!  Melissa's Recommendations & Affiliations  Get Melissa's Recommended Oura Ring  Follow Melissa on Instagram  Follow Melissa on Youtube  Find out more about Melissa  Get Access to the MADE Diet Course Get The MADE Diet Ebook  Learn More About Larimar Med's Services Follow Dr. Fitz on Instagram  Follow Dr. Fitz on Youtube Thank you so much for listening to this episode! We are honored and excited to be on this journey toward personal growth, a healthy lifestyle, and a greater more confident you. We'd love to hear from you. So, please share this episode with anyone that you think needs to hear this message and remember to rate, review and subscribe wherever you listen to podcasts. We are Melissa McAllister & Dr. Lauren Fitzgerald. And until next time, thank you for being your own health advocate.  xo, Melissa & Dr. Fitz  

In this episode, Alicia McLucas discusses behavior change, habit formation, and mindfulness practices. Alicia shares her inspiring journey of reversing type 2 diabetes through behavior modification and nutrition.  Alicia discusses topics such as identifying personal values, reducing stress through mindfulness, and overcoming emotional eating. This conversation addresses the profound impact of stress on behavior change and the importance of mindfulness in stress management.Subscribe & ReviewSubscribing and leaving a rating and review are important factors in helping the Reshape Your Health Podcast and the YouTube Channel reach more people. If you haven't already subscribed, please do that today.We would also be grateful if you left a rating and review, too. In your listening app, scroll to the “Ratings and Reviews” section, then click “Write a Review” and let us know what you enjoy about our show. We appreciate you taking the time to show your support. Thank you!Resources From This Episode>> Insulin Resistance Diet Starter Course>> Join Zivli>> Test Your Insulin at Home>> Free Low Insulin Food Guide>> Free Master Your Macros Training Videos>> Alicia McLucas' Instagram>> Alicia McLucas' Website

Discover strategies for coping with a cancer diagnosis, both for individuals and their support networks, while also exploring methods for assembling a tailored support team.Kelly Lutman, a certified health coach specializing in Applied Functional Medicine, brings a wealth of insight stemming from her personal journey and professional expertise. With a focus on the profound impact of nutrition on health, Kelly approaches each client's needs with sensitivity and understanding, emphasizing the body's innate ability to heal when provided with proper nourishment and support. Her holistic approach encompasses dietary adjustments, stress management techniques, and environmental considerations, all aimed at promoting vitality and well-being.In this episode, Kelly delves into her book, 'Thriving Through Cancer: A Holistic Approach for Your Journey,' which serves as a comprehensive guide for individuals navigating cancer treatment. Emphasizing the crucial role of a positive mindset, grounding practices, and nutritional optimization, she underscores the significance of addressing both physical and emotional aspects of health. Additionally, Kelly sheds light on the principles of functional medicine in managing conditions such as IBS and type 2 diabetes, highlighting the body's remarkable capacity for resilience and healing.Listeners will gain valuable insights into establishing a supportive network, cultivating a constructive outlook, and implementing practical wellness strategies. The episode concludes with information on accessing Kelly's resources for further guidance and support.Welcome to the Holistic Health Show with Kelly Lutman, where empowerment and holistic healing intersect to foster resilience and well-being.- Explore Kelly's journey from accounting to health coaching, marked by a pivotal moment in addressing ADHD through dietary modifications.- Gain insights into the principles of functional medicine and its application in empowering cancer patients to optimize their health.- Discover the importance of cultivating a supportive environment, maintaining a positive mindset, and embracing simple wellness practices.- Learn about the transformative potential of nutrition and lifestyle adjustments in promoting overall health and vitality.- Access Kelly's book, 'Thriving Through Cancer,' and additional resources to embark on a holistic journey towards well-being.The episode concludes with information on how to access Kelly's resources for further assistance.00:00 Welcome to the Holistic Health Show with Kelly Lutman00:43 Kelly's Journey from Accounting to Health Coaching01:21 The Turning Point: Addressing ADD Through Diet02:22 From Health Coaching to Functional Medicine03:14 Empowering Cancer Patients: A Holistic Approach05:32 The Importance of a Supportive Team and Positive Mindset11:46 Grounding and Simple Wellness Practices13:53 Nutrition and the Power of Chewing15:33 Adapting to a Healthier Diet and Lifestyle16:57 Thriving Through Cancer: Kelly's Book and Resources18:25 Building Your Support Network and Making Informed Choices22:20 Closing Thoughts and How to Connect with KellyAuthor: The Holistic Health ShowGuest Speaker: Kelly Lutman, a health coach trained in functional medicineCategory: Health and WellnessPublish date: 2024-04-19Support the showThanks for listening! SUBSCRIBE to The Holistic Health Show today and embark on a transformative journey towards a more harmonious and balanced life.Follow us on Facebook, Instagram and YouTube!

Welcome, listeners, to another intriguing episode of DITCH THE LAB COAT. I'm your host, Dr. Mark, and today we've got a particularly compelling show that delves deep into the complexities of obesity medicine. In episode four, we're honored to have obesity and type two diabetes expert, Dr. Sean Wharton, join us to unravel the mysteries of this fascinating and often misunderstood field. Dr. Sean Wharton, Specialist in General Internal Medicine will shed light on how obesity, a disease mired in stigma and misconception, impacts much more than one's physical appearance—it intertwines with psychological states and numerous other medical conditions ranging from cognitive disorders to cardiovascular diseases.Prepare to challenge what you thought you knew about weight management as we discuss the genetic components of obesity, the effectiveness of medications, and the societal perceptions that shape our response to this modern epidemic. This isn't just about the numbers on a scale; it's about understanding the human element behind the struggle with weight, the unseen battles with societal expectations, and the cutting-edge medical interventions that are reshaping lives.Now, let's strip away the stereotypes and biases as Dr. Sean Wharton guides us through the medical and psychological impacts of obesity, the latest research on genetic predispositions, and the innovative treatments leading the charge against this chronic condition. Are you ready to ditch the lab coat and dive into the heart of the matter? Let's get started.00:00 General internist explaining role as non-surgical doctor.04:57 Listen to people with obesity, avoid defining.06:21 Obesity's medical and psychological impacts on health.10:33 Obesity connected to health issues, including diabetes.13:26 Smoking and cancer risk linked to environment.17:01 Genetic predisposition to preserve fat in modern society.21:01 Understanding thinness: a genetic puzzle unsolved.26:16 David Allison criticized calorie signboards, lost job.28:55 Obesity driven by genetic desire for calories.30:53 Compassion and understanding key in treating genetics.35:26 Redundant system for weight regain hormonal response.38:17 Developing super pill with glp one mixture.40:40 Medications may increase risk of pancreatic cancer.45:36 Access to medical treatment affects obesity in Canada.49:50 Parenting challenges, obesity, and societal attitudes addressed.

In this episode of the Unlock the Sugar Shackles podcast, I interview The Food Babe, Vani Hari, a passionate advocate for healthy food choices. Vani shares her personal experience growing up with fast food and how it influenced her eating habits. She also discusses what Big Food doesn't want consumers to know, as well as her journey of taking on food giants like Kraft, Starbucks, Chick-fil-A, and Chipotle. Tune in to learn more about Vani's story and what inspired her to make a difference in the food industry and how you can help make better choices for you and your family!TODAY'S SPONSORSGOOD IDEA: Use code DANIHEALTH for 10% off your order! TODAY'S GUESTNamed as one of the “Most Influential People” on the Internet by Time Magazine, Vani Hari is the revolutionary food activist behind FoodBabe.com, co-founder of organic food brand Truvani, New York Times best selling author of Food Babe Kitchen, The Food Babe Way, and Feeding You Lies. For most of her life, Vani ate whatever she wanted—candy, soda, fast food, processed food—until her typical American diet landed her where that diet typically does, in a hospital. Despite her successful career in corporate consulting, Hari decided that health had to become a priority. Her newfound goal drove her to investigate what is really in our food, how it is grown and what chemicals are used in its production. The more she learned, the more she changed and the better she felt. Encouraged by her friends and family, Hari started a blog called foodbabe.com in 2011. It quickly became a massive vehicle for change. She has led campaigns against food giants like Kraft, Starbucks, Chick-fil-A, Subway and General Mills that attracted more than 500,000 signatures and led to the removal of several controversial ingredients used by these companies. Through corporate activism, petitions, and social media campaigns, Hari and her Food Babe Army have become one of the most powerful populist forces in the health and food industries. Her drive to change the food system inspired the creation of her new company called Truvani, where she produces real food without added chemicals, products without toxins, and labels without lies. Hari has been profiled in the New York Times and The Atlantic, and has appeared on Good Morning America, CBS This Morning, CNN, The Dr. Oz Show, The Doctors, and NPR. Vani lives in Charlotte, North Carolina with her husband Finley and two children. Visit her online at: foodbabe.comHer new cookbook, Food Babe Family will officially hit stores October 17, 2023.Instagram: @thefoodbabeFacebook: @thefoodbabeSTAY IN TOUCH WITH ME:Instagram @daniellehamiltonhealth Facebook at Danielle Hamilton HealthMy website is daniellehamiltonhealth.com (scroll down to sign up for my Newsletter!)Thank you for subscribing, ratin

Samoa has among the highest rates of obesity and type two diabetes in the world. Amy Maslen-Miller, also known as the Samoan Scientist, is a current PhD candidate at the University of Auckland, dedicating her time to researching how a traditional Samoan diet can help prevent type two diabetes in our Pasifika population. Her research goes all the way back to studying the diet and lifestyle of the 19th and early 20th centuries.

Health researchers say the government needs to take large scale action to prevent an emerging type two diabetes pandemic. Overseas research shows the number of people diagnosed with type two diabetes has increased in the past years, reaching a staggering 483 million people globally. Professor Jim Mann from the University of Otago is a scientist at the forefront of diabetes research, and was invited to write recommendations on the latest research. He spoke to Ingrid Hipkiss.

Hello everyone and welcome back to the podcast! I hope you all have had a wonderful week! This week (14th-20th of November) is  Sugar Awareness Week! To bring this wonderful week to a close, I bring you a podcast about sugar and the common condition, type 2 diabetes, and how they relate. This is a fascinating topic! Listen to this episode now and let's take a deep dive into the literature on sugar and type 2 diabetes. Check out my Instagram (and other health professionals) to learn more about sugar and why we should be careful about how much we consume. Get in touch: Email: gardnermairi12345@gmail.comInstagram: mairihgardnerTiktok: mairigardner57 Blog: aaahealths.com Website: www.mairigardner.com Do you have any questions about what I offer and how I can help you? Book your FREE 15-minute session today @ www.mairigardner.com I would love to chat! Remember to share, like, comment, and follow along for more! 

Type two diabetes has become such a common disease. Earlier this year in January 2022 statistics indicated that 37.3 million Americans—about 1 in 10—have diabetes. While this disease is common in what often appear to be otherwise healthy individuals I want to take a closer look at what diabetes is in this episode. PCOS puts women at high risk of type two diabetes in fact many women that I meet have already been diagnosed with pre-diabetic or diabetes even in their 20s and 30s.So what is diabetes and how does it impact the body? Well my friend that is exactly what this episode is about Welcome back to the PCOS repair podcast where today we're going to dive a little deeper into the insulin effect root cause of PCOS and type two diabetes as well as how you can decrease your risk of developing it. PCOS, Insulin, and DiabetesInsulin can be confusing, so let's start with insulin and the spectrum of healthy to the diseased state of type two diabetes.The spectrum has four stages:Healthy insulin receptors that are responsive to insulin and easily allow blood sugar to enter your body's cells. AND insulin levels are routinely at an appropriately low number.The body has higher than normal levels of insulin circulating the body on a continual basis due to diet and lifestyle or the beginnings of insulin resistance.Insulin resistance and Prediabetes: This is the point where your lab values are beginning to be or clearly elevated but haven't quite reached the diabetic level.Then comes the official diagnosis of Type Two Diabetes: over time this creates blood vessel complications leading to a risk of heart disease, stroke, heart attack, vision decline, and even blindness, kidney failure or nerve damage, and more. You can see that though common this disease of type two diabetes isn't something you want to have. Reduce The Risk of Type Two DiabetesWhile type two diabetes is something that every human is at risk of developing if they don't follow lifestyle measures to prevent it, women with PCOS are at a higher risk of developing type two diabetes and at an earlier age. That is why this episode is important to me! I know most of you are already aware of this increased risk of type two diabetes and some of you have already been diagnosed with it. This episode is not about creating fear instead, it's about bringing something scary into the light and discussing what we can do to improve our health and PCOS symptoms no matter where we are currently on that spectrum of insulin and diabetes. So if you are ready to reduce your risk of type two diabetes go ahead and listen to this episode now. A full list of Resources & References Mentioned can be found on the Episode webpage.

Why do we take respiratory performance seriously? You will hear from breathing expert Nick Heath in this episode, who has benefited from his breathwork practice to reduce the effects of diabetes. 

Ryan Paul discusses fasting in the patient with type 2 diabetes.

Show Notes Dr. Tara Scott, OB/GYN   - Nutrigenomic Nation Podcast with Brian Highfield   - Episode 051 Dr. Tara Scott, OB/GYN Dr. Tara Scott is the founder of Revitalize, a medical practice that focused on wellness and stress from a hormonal perspective. Her online course, Revitalize Academy, helps patients improve their hormone problems themselves. After suffering from infertility and curing her own endometriosis, she now helps others achieve that same balance.   Dr. Tara first became involved with hormone and integrative medicine while practicing as an OB/GYN. The American Academy of Anti-Aging Medicine also trained and certified her. In the Fall of 2021, she gave a TEDx talk on tools to manage stress. Dr. Scott is also a vigorous advocate for individuals investing in their health. Highlights of our conversation include: How high cortisol disrupts glucose metabolism, increasing the risk for heart disease and diabetes. The importance of knowing heart math and heart rate variability monitoring. Working to understand the causes of infertility. Type Two Diabetes is preventable and reversible. Preventing breast cancer. Making exercise and healthy diet choices a habit to become a natural routine. Enjoy the show!   Connect with Dr. Tara:   Website: https://revitalizemed.com/   Website: https://drtarascott.com/   Facebook: https://www.facebook.com/drtarascott/   Connect with Brian: Website: thebeardedphilosopher.com and biohackyour.life Facebook: @Nutregenomicnation Instagram: @therealbeardedphilosopher Learn more about your ad choices. Visit megaphone.fm/adchoices

Did you know that 44% of all American adults have diabetes or pre-diabetes? And one-fifth of all the people with diabetes don't even know they have it! While there is many serious medical implications of having elevated blood glucose, it might also be a cause of low energy. Our guest, Jill Weisenberger, MS, RDN, a Certified Diabetes Care and Education Specialist, shares three things you can do to prevent diabetes, that will also boost your energy level. Jill is the author of four books including Pre-diabetes: A Complete Guide, Diabetes Weight Loss Week by Week, and the e-guide, The Beginner's Guide to What to Eat with Type Two Diabetes. ___ Host, Dr. Jo Lichten, PhD, RDN, CSP is an energy expert...for people. Blending the science of peak performance with a healthy dose of reality, she works with organizations to recharge their people for improved performance, productivity, and profitability. Dr. Jo is a professional speaker (LIVE and VIRTUAL), wellness coach, and author of 6 books including, REBOOT - how to power up your energy, focus, and productivity. How's your energy? Take Dr. Jo's Energy Quiz and find out. To learn more and to invite Dr. Jo to speak to your organization, visit DrJo.com. ___ Like the podcast? Please ❤❤REVIEW and ❤❤SUBSCRIBE to my channel. ___ FOR MORE INFORMATION · Struggling to stick with your healthy eating goals? Get Jill's Report · Dr. Jo · Contact Dr. Jo · Dr. Jo's SPEAKER REEL · Dr. Jo's REBOOT Book · Coaching with Dr. Jo · Guest, Jill Weisenberger _____ DISCLAIMER · As a PhD nutritionist and registered dietitian, my mission is to help energize people's lives so they can be happier, healthier, and more productive. This involves blending the science of peak performance with a healthy dose of reality. · Nutrition, wellness, and general health information is for educational purposes and not a substitute for personalized professional medical care. Please consult your medical care professional about any health issue. _____ SAY HI on SOCIAL! · LinkedIn · Facebook ----- #diabetes #prediabetes #DrJo #healthspeaker #wellnessspeaker #nutritionspeaker #Florida #motivationalspeaker #CSP #certifiedspeakingprofessional #author #REBOOT #energymanagement #workplacefatigue #peakperformance #lifebalance #DrJoHS #betterhealth #humanperformance #podcast #dietitian #registereddietitian #nutritionist #RD #RDN #resilience #stressmanagement #corporatewellness #corporatehealth #TWH --- Send in a voice message: https://podcasters.spotify.com/pod/show/drjo/message

Dr Michael Mosely explains how diet can reverse cases of type two diabetes See omnystudio.com/listener for privacy information.

Dr Glen Davies talks about reversing type two diabetes

Harri Paddan and I met through the day job, and every conversation I have with her inspires and energises me. Last time we spoke, she shared her story with me around her changed relationship with food due to a diagnosis of Type Two Diabetes. It's thanks to Harri's own determination to explore and find out more about food and how her body needed her to change that she has reversed that diagnosis. Join us as we explore her story, and I share a little of mine. You can reach out to Harri on Instagram @harripaddan

Can we inherit type two diabetes? Who is Albert Stunkard ? The spark of the diabesity epidemic These are the guidelines that made the diabesity epidemic worse Ztime Podcast Emotional Wellbeing, Physical wellbeing, relationship wellbeing, financial wellbeing, community wellbeing. Ztime Podcast. Dr. Andres Zuleta, Andres Zuleta MD, Dr. Zuleta Diabetes and obesity epidemic. Diabetes remission, Type 2 Diabetes How did we get to this obesity epidemic Dietary goals for the United States / prepared by the staff of the Select Committee on Nutrition and Human Needs, United States Senate. United States. Washington : U.S. Govt. Print. Off., 1977. http://hdl.handle.net/2027/uiug.30112023368936 George Mcgovern Can we inherit type 2 diabetes The genetics of type 2 diabetes. Parental olfactory experience influences behavior and neural structure in subsequent generations https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3923835/ Reversing Behavioral, Neuroanatomical, and Germline Influences of Intergenerational Stress https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6326876/

  2:00 Brian‘s personal story of health recovery 5:43 the book be your own doctor. 6:13 when do you need a doctor and when do you not need a doctor 7:12 Anne Wigmore 8:00 what did doctors use 100 years ago 11:30 His condition for becoming the director of Hippocrates was being allowed to find out why scientifically the Institute was able to reverse multiple sclerosis, Parkinson's, Lou Gehrig disease, Alzheimer's disease, cancer, heart disease, type two diabetes 14:32 Paleo diet 18:00 The medical test that Hippocrates does on a regular basis 18:57 genetics has nothing to do with cancer 19:11 Dr. Michael Gregor 20:06 Dr. Martin Catan 21:35 how animal fat surrounds the cell and blocks Sell from receiving sugar. Cell can't utilize the sugar and then the sugar raises blood sugar diabetes 22:58 Serena Williams 23:48 bodybuilders and Fighters 24:50 why do people lose weight when they go on a meat diet 27:56 the forbidden cures 28:21 Huxley 29:10 business should be capitalistic health should be socialistic 33:30 and MDs psychology and why it's so hard to shift paradigms 42:45 Eating meat and dairy is the number one way to destroy the planet 46:07 diabetes epidemic 46:36 Lou Gehrig's disease 47:00 25% of us will get Alzheimer's 49:00 he gets pulled from the Regis Philbin show 49:17 mad cow disease Oprah Winfrey 50:39 if you think this isn't something that's being orchestrated against you at the highest levels then why DON'T you know about Hippocrates? 54:31 Bill Clinton, Dr. Hymen, Dr. Esselstyn  58:30 HippocratesInst.org

Episode 148 Andrea Sereda has lost over 150 pounds and reversed her Type 2 Diabetes and Fatty Liver Disease!! You definitely want to see her BEFORE & AFTER photos from in the show notes!! They're going to BLOW YOUR MIND!! If you need inspiration on your own health and weight-loss journey, look no further than this episode! Andrea's story has literally everything you need to begin your own journey to a NEW and HEALTHIER YOU! Tune in via Spotify, Stitcher, iTunes or anywhere you listen to podcasts online or click on this link to listen! xx Corinne

This week.. what is monogenetic diabetes and why should we – on a mainly type 1 diabetes podcast – care about it? The majority of people with monogenic are misdiagnosed as type 1. People like Kristin Skiados who thought she’d lived with type 1 for 38 years and her daughter Ava, was also misdiagnosed. MODY Quiz - Probability Calculator  We’ll talk about how this could happen, what it means for the rest of us and what monogentic or MODY is all about. Check out Stacey's new book: The World's Worst Diabetes Mom! In Tell Me Something Good, how a little sister’s diagnosis changed a sibling's outlook and career.. And what the heck is a diabetes merit badge? We’ve got em! (Find out more here) This podcast is not intended as medical advice. If you have those kinds of questions, please contact your health care provider. Join the Diabetes Connections Facebook Group! Sign up for our newsletter here ----- Use this link to get one free download and one free month of Audible, available to Diabetes Connections listeners! ----- Get the App and listen to Diabetes Connections wherever you go! Click here for iPhone      Click here for Android Episode transcript (rough transcript, please forgive grammar, spelling, punctuation)  Stacey Simms  0:00 Diabetes Connections is brought to you by One Drop created for people with diabetes by people who have diabetes by Real Good Foods, real food you feel good about eating, and by Dexcom take control of your diabetes and live life to the fullest with Dexcom.   Announcer  0:21 This is diabetes connections with Stacey Simms.   Stacey Simms  0:27 This week, what is monogenetic diabetes? And why should we on a mainly type 1 diabetes podcast care about it? Because the majority of people with monogenetics are misdiagnosed. people like Kristin Skiados who thought she was living with type one for 38 years.   Kristin Skiados  0:44 It really was a phone call that was the answer to a new life. And it was probably the first time that I was speechless on the phone and the fact that That this meant there was a possibility to not be on insulin was just amazing   Stacey Simms  1:06 Kristin’s daughter was also misdiagnosed. We'll talk about how this could happen, what it means for the rest of us and what might have genetic or MODY is all about in Tell me something good. How a little sister's diagnosis changed a sibling’s outlook and career plans. And what the heck is a diabetes merit badge? I got them. This podcast is not intended as medical advice. If you have those kinds of questions, please contact your health care provider.   Welcome to another week of the show. I am so glad to have you along here on Diabetes Connections. We aim to educate and inspire about type 1 diabetes by sharing stories of connection. I'm your host Stacey Simms. My son was diagnosed 13 years ago right before he turned two I don't have diabetes. I do have a background in broadcasting and that is how you get the podcast. Hello to any new people joining us from the Raleigh Durham, North Carolina area. As this podcast is airing, I am just back from the JDRF type one nation summit in that area and thrilled to meet many new people and see some familiar faces. Not too long a trip for me. Of course, I'm in the Charlotte, North Carolina area, but always fun to go to those conferences, see people in person, talk about the show, talk about the book, the world's worst diabetes mom, and make those connections that I care so much about. And this is the second time that I have taken the diabetes merit badges on the road. I am so excited about this idea. This came to be I guess it's one of those ideas that came kind of suddenly but then was also years in the making. I have always thought that we deserve like a gold sticker or a huzzah! Or hurray when something goes right in diabetes land. You know,There used to be a joke in the community that when your meter read 100 that confetti should come out of You know, stuff like that. But when I was writing the world's worst diabetes mom I even mentioned in one of the chapters when I talk about the first injection I gave Benny at home that I really felt like I had done something monumental and I wanted to you know, shout it to the world. And that's how the nighttime ninja sticker was born. So they are kind of silly. Yes, there is one that is a nighttime ninja. These are actual stickers. When I say merit badge, I mean, these are stickers that you can buy things like date night diva, which means you had a conversation without checking your CGM data 1000 times hold music marathoner finally spoke to a supply company representative dia-diplomat, calmly explained that sugar doesn't cause diabetes, insurance hoop jumper, and on and on. A lot is are geared to diabetes parents, which is obviously my perspective, but I teamed up with Rachel at diabetees who's a previous guest to the show and very popular in the community for her amazing shirts at her great Etsy store. So I'm going to link up in the episode homepage and on social media, more about these stickers, you can buy them in batches. I also have a sticker that's not in the Etsy store yet. And it is wanted for not waiting. It's the DIY cowboy sticker. Because that is for my friends at night scout and all of you who are not waiting, we're gonna do something fun with that, maybe a fundraiser for them. We're still working out the details. As I said, this came on kind of quickly. I decided in December that this might be a really fun idea. And I called Rachel and she was like, Yes, I'm in and I gave her a bunch of the ideas. And she came up with a couple of them herself. And then she's a genius when it comes to the pictures and the drawings and it really came together beautifully. So right now, there will be a link in the episode homepage. Diabetes Etsy store is the only place you can buy the stickers right now. And I have them on my book tour and Rachel as she goes out and about the conferences, she will have them as well. I'm really excited about them. They're very funny and silly and just a little bit of a pick me up. And if you have ideas for these as you see them and you can see all of them and her Etsy store, let us know we will definitely add as we go if they're popular and people really want them. Love to hear what you have to say A quick note, this interview is longer than usual. But it is a very complex, frankly, and a very interesting subject and I didn't want to stop talking about it. So I'm doing something a little different. For this episode, we're going to do about half the interview. Then we'll go into our Tell me something good segment. And then I'm going to pick the interview back up. You can always listen to episodes on your own schedule, of course, but I just felt this was a really nice way to lay this episode out with an interview. That by itself is more than 45 minutes. Regardless, the whole thing will be transcribed on the episode homepage. I am thrilled people are loving the transcripts. So if you are one of them, please reach out and let me know. I'm so excited to finally be able to offer this I know a lot of people wanted it Thinking about trying to go back and do more episodes in the past, we shall see. All right diabetes Connections is brought to you by Real Good Foods -  high protein, low carb, real ingredients. easy to find in a store near you, you can just go to the website, click on that store locator. Type in your zip code in our area. I can find them at Publix, Harris Teeter and at Walmart. And if you'd like to order, their website is fantastic. Lots of great options. I mean, all of the options are on the website. Great breakfast sandwiches, grain free, high in protein, low in carbs, because they use ingredients like cauliflower instead of processed flours or processed starches so you don't get those weird sounding ingredients or weird preservatives. And you can find the list of ingredients right online very easy for the all of the ingredients are on the website, find out more, go to diabetes, connections dot com and click on the real good foods logo. My guests this week are here to talk about monogenetic, diabetes The type of diabetes caused by a genetic mutation. There are about 10 different types of diabetes that are genetic like this. And we are talking about a specific one today. These are all very rare. Together, they account for about one to 2% of all types of diabetes, but they are very often misdiagnosed, and usually misdiagnosed as type one. If you have monogenetic diabetes, you almost always don't need insulin, you take oral medication, so it is a big deal. Now I have to admit, I struggled a little bit with this interview. I remember vividly researching, when Benny when my son was diagnosed, I was so hoping that it would be monogenetic, MODY or something else. And I struggle now, because there's not an easy test for this. You can't just call your doctor and get a quick result. As you will hear it is more complicated. So as you will hear me ask, what are we supposed to do with this information right? My guests are Kristin Skiados who lived with type one for 38 years before genetic testing showed she didn't actually have it. And we'll hear briefly from her daughter, Ava, also misdiagnosed for years. And Dr. Tony Pollin, a Board Certified genetic counselor, a human geneticist, and she works with the mano genetic diabetes research and advocacy project that is aiming to get universal access to diagnosis and individualized treatment. So here is my interview all about monogenetic diabetes. Dr. Pollin and Kristin, thank you for talking to me. I am fascinated with this and I'm so excited to learn more. Thanks for spending some time with me.   Dr. Toni Pollin  8:43 Thank you for having us.   Stacey Simms  8:46 Let me start with with you Dr. Pollin, let me just ask you, what are we talking about here? You know, I know people we know there are different types of diabetes. But what is mono genetic   Dr. Toni Pollin  9:00 So if you just kind of, you know, break down, monogenic, you have mono, which is one, and then genic, which is gene, what it means is that there's one gene that's really important in certain cases of diabetes. And we actually know that almost all diabetes is highly genetic. It has a lot of hereditary influence, you know, so their genes, their variations in our DNA that we inherit for from our parents that act in concert with other factors to determine whether or not we get diabetes and whether or not we get type 1 diabetes, or type two diabetes, which even itself is a lot of different diseases. But for some cases of diabetes, the genetics is actually a lot simpler. There's some very specific change, like a misspelling and a gene that causes a person to have diabetes makes them very, very likely to have diabetes really explains most of it. So when we say monogenic, we mean that the cause of the diabetes can largely be explained by a change or difference or mutation in one single gene and that person,   Stacey Simms  10:07 and how is it treated?   Dr. Toni Pollin  10:08 how its treated is it depends on the type. So it's going to sound a little bit contradictory because I just said monogenic. But there's actually several different forms because depending on the individual, they might have their several different possible genes that can be involved. But when an individual has monogenic diabetes, it's one gene. Again, that's explaining most of their diabetes. And so depending on the type of diabetes, the treatment will vary, so some types of monogenic diabetes, the diagnosis doesn't make that much of a difference, but the one that's ones that were most interested in and actually the most common types, that does make a difference. So there's one type of monogenic or one kind of group of types of monogenic diabetes called maturity onset diabetes of the young, and that sounds like a strange name, but that was an observation made in the 70s 60s 70s even earlier, when it was realized that some children had diabetes that looked more like the type that older people got. They didn't need to be treated with insulin and they actually some of them responded really well to oral medications. And so getting back to your question, which is how is it treated? Some people with certain kinds of monogenic diabetes called sometimes these types are called Modi, three and moody one, and they're caused by genes and changes in genes.. And those are treated with low doses, a very old class of drugs called sulfonylureas, and these are drugs that help the pancreatic beta cells to make and release insulin,   Stacey Simms  11:44 those medications is that like Metformin or these oral medications?   Dr. Toni Pollin  11:48 There are medications but what's interesting is back when these types of diabetes were first discovered, when it was discovered that you know you had these children who didn't quite fit either way, they were kids They were part of the way they why and maybe part of why they call it maturity onset diabetes of the youngest because they responded to the medication that was used in adult diabetes, Metformin did not exist. Back in the 60s, there was only one kind of oral medication, there's only really one medication besides insulin that could treat diabetes. And that was a class of drugs called sulfonylureas. So that's things like glyburide, and other drugs like that. And what those drugs do is they help the body to make insulin. They help to stimulate the body's capacity to make insulin and to secrete the insulin and really they said stimulate the body's capacity to secrete the insulin. And so the drug Metformin is is among many drugs. And sulfonylureas still use, but Metformin is actually safer. And so and it's, it's often the first drug that's tried and type two diabetes. The problem is if you think somebody has type two diabetes, and they really have one of these modes, These are these transcription factor types of diabetes, then they won't respond because their problem is in secreting insulin. Metformin helps you to respond to insulin. Metformin is what's known as an insulin sensitizer. So,   Stacey Simms  13:12 but I took you down that road because I mentioned Metformin.   Dr. Toni Pollin  13:15 So that's fine, though, because that's important. And that's actually ironically, one of the reasons why a misdiagnosis is even more of a problem today than it was a long time ago, because it used to be that people were treated with the type of drugs that actually work with monogenic diabetes. Yeah, so yeah, so but that's just one of the treatments. Now, there's another whole kind of class of monogenic diabetes that doesn't actually require any treatment. And so this is due to a partial deficiency of an enzyme called glucokinase. That kind of tells the pancreatic beta cells that there's glucose around and catalyzes a chemical reaction to people who have that form. They actually have a lifelong Mild hyperglycemia that if it doesn't have any other causes, then it's it's largely benign. And it actually doesn't respond very well to treatment. So knowing that you have that form, which is called glucokinase diabetes means that you could discontinue treatment.   Stacey Simms  14:16 All right, Kristin, let me bring you on because you lived with what you thought was Type 1 diabetes for a very long time. Can you tell us your story?   Kristin Skiados  14:26 Yes, I was diagnosed at the age of five, back in 1980. And I had all the classic symptoms of type 1 diabetes. As a matter of fact, when my parents didn't know what was going on with me, one of my friends moms was a nurse. And she said, geez, yeah, I think she might have diabetes, and I ended up in the hospital and the very high glucose. they diagnosed me immediately with type one, and I was put on Matter of fact, I was put on purified pork insulin, and then move to bovine and, and I stayed on insulin for a better part. Love for 38 years. I didn't move on to a pump when I turned 25. And life was just normal for me. I don't ever remember not being diabetic. And I think that was a good thing. I was so young when I was diagnosed, and I don't know what life is like, not having it. And I know it was an adjustment for my family for my siblings, because, you know, my mom made them do all the same things I did minus the blood sugars and the insulin. But they had to eat it and they had to have snacks and they had to get up early to and it just became a norm in our house. Yeah, I went to college, I did all these great things, traveled, played sports, got married my husband and had two kids.   Stacey Simms  15:57 Alright, so fast forward then. So Your daughter Ava, who is now 11. She was diagnosed with type one as an infant. And I imagine that that was, you know, devastating not only because you you've already been through it yourself, but she was so young she was 15 months.   Right back to Kristin in just a moment, but first diabetes Connections is brought to you by one drop, one drop his diabetes management for the 21st century. One drop was designed by people with diabetes for people with diabetes. One drops glucose meter looks nothing like a medical device. It's sleek, compact, and seamlessly integrates with the award winning one drop mobile app, sync all your other health apps to one drop to keep track of the big picture and easily see health trends. And with a one drop subscription you get unlimited test strips and lancets delivered right to your door. Every one drop plan also includes access to your own certified diabetes coach have questions but don't feel like waiting for your doctor visit, your personal coach is always there to help, go to diabetes, connections calm and click on the one drop logo. Now back to Kristin, talking about her daughter's diagnosis.   Kristin Skiados  17:17 You can have a little bit of the same classic symptoms that I had. A few things were different. And when I kind of looked back on it in hindsight, there were signals kind of all along, I think, you know, she had thrush in her mouth as an infant a few times. She always had yeast infections, diaper rashes. When I look back on it, we're like, oh, maybe this was the manifestation of this but when she was 15 months old, she was still 17 pounds. She was eating a ton of food. I mean, she was the top of the zucchini, whole sweet potato, half a chicken bread. You know drink milk yogurt. Then two hours later, we're drinking more milk or having more yogur getting up in the middle of night. He wasn't excessively peeing all the time. You shouldn't have frequent urination. But she was just underweight. You know, she was the amount of food she was eating didn't match what her weight should be. So I kind of had it in the back of my mind. Well, maybe she has diabetes. She had bronchitis before she turned a year old that we went and we got the blood work done. And her fasting glucose was not actually overly high. It was in I think, the 200 but she was diagnosed as type one. And we had compounded insulin, they had a you know, dilute her insulin because of her at her knees and, and it was devastating in the fact that this was something I never wanted her to have, you know, so there was this mother's guilt of my gosh, you know, she got this from me. And that was Very difficult to deal with and, you know, not so much myself having diabetes, but now my daughter was going to have to do the same things I have to do. And her life wasn't going to be normal. And we had to say goodbye to that normalcy was almost like a death. You know, it was the life that we knew was now gone. And we had to readjust and, you know, her insulin had to be on ice. I had to be cold all the time. So we were always walking around with our refrigerated bags, we have tons of ice packs,   Stacey Simms  19:33 is it because it was diluted it had to be cold,   Kristin Skiados  19:35 okay, and in where we live, we don't have compound pharmacy, so it had to be shipped from Baltimore. Well, and it's the same thing my parents went through this this everything's turned upside down and falling in her blood sugar's every night 7pm constantly changing insulin to carb ratios and, you know, she was on shots and half unit so you know, trying to draw half Unit insulin doses and it was overwhelming. And this is coming from me who's lived with diabetes. It kind of knows more than the average person, you know, but even still, it was a huge adjustment. It was really, really hard. It was a hard pill to swallow life. Now with two diabetics in the house. A lot of care went into Ava, you know, I kind of put myself on the back burner for a little bit trying to manage her and manage me and it was a challenge and being that younger son couldn't communicate with me,   Stacey Simms  20:33 right? That's so difficult. So when in this journey then because here we are talking to you on a podcast about mono genetic diabetes. When did you find out what she really had   Kristin Skiados  20:46 said we were at one of her just regular checkup appointments at University Maryland and Medical Center, and Ava's nurse. She had presented us with this study. Asked if we wanted to participate. And I spoke on behalf of Ava and said yes. And being a biologist myself. I thought monogenic diabetes. And when Ava was diagnosed, I kept saying, How does she get type one like there is that genetic component to it, but for type one day, I think to be passed on Dr. Paul, and you can certainly correct me if I'm misspoken here, there's a lower percentage of inheritance rate for type one computer, obviously, money. So I can see, you know, all the research at the time when she was diagnosed with stem cells, stem cells, stem cell, I wanted genetics, genetics, genetics, and nobody was doing genetics. And so when this opportunity came about, I was like, Yeah, I want to find out more about this. I'd never heard of monogenic diabetes. And I started reading up on it and I thought, This is what I've been looking for. This is what I wanted now. So we entered Ava into the study, and got our blood work done and just waited for our results.   Stacey Simms  22:06 And how old was she at the time?   Kristin Skiados  22:08 She just turned nine.   Stacey Simms  22:09 Oh, so this has been going on for a very long time. This is her whole childhood. And Toni, let me ask you, I understand, how do you live with what you think is type one and it's really something else. I mean, is it dangerous to be on an insulin pump? Is it dangerous to be treated like a type one when you when you actually have something else?   Dr. Toni Pollin  22:31 Well, in some cases, it's not necessarily acutely dangerous, you know, because the problem in all diabetes is the problem with blood sugar. And in certain types of monogenic diabetes, it's because you're not producing enough insulin. You can treat it with insulin and that'll be okay. But there's a couple of reasons why it would be preferable not to do that. And one would be of course, as I think Kristin and Ava will be able to tell you about Better than I can that most people seem to prefer taking a pill to wearing a pump or doing injections. But the other thing is that when you think about, you know, just think about anything that you have wrong with you. It's almost like you know, you can put a bandaid you can kind of treat it superficially, or you can treat it in a more in a kind of deeper way you can treat the underlying problem sometimes not everybody, but for some people, they might be fine on insulin as Ava and Kristin were, but you might be able to be even better if you're treating the underlying problem.   Stacey Simms  23:31 Alright, so let's go back Kristin. Ava's nine, you get the results. Were you both in the study or did Ava get the results in that? They said, Hey, Mom, we better check you too.   Kristin Skiados  23:41 Well, you know, when the study was first presented, I said, Hey, can I get in and they said only if Ava's positive and  she presents a mutation. So she had her blood work done in May and we got the official diagnosis on December 5, and I get it. Like I always get choked up talking about that phone call because it really was a phone call that was the answers to a new life. And it was probably the first time that I was speechless on the phone with that with Dr. Three, and he had called me with the results. And the fact that this meant there was a possibility to not be on insulin was just amazing. When we were going through this study, we never really presented much to Ava, because we didn't want to give false hope. You know, we didn't want to build something up that might that may or may not be when we were going through this. You know, we just said what we're going to see if your diabetes can be treated differently. When we got the news that she had kcp diabetes, often known as MODY 13 this is one of the forms Where you can take sulfonylureas instead of insulin. But that's it, you know, it's a 90% success rate of 10% failure rate. So that was something that we didn't want to, once again get our hopes up with her. So we were very cautious with how we proceeded through this whole thing. You know, the news of her having this mutation was amazing. It was probably one of the greatest days of my life. And then that meant Hey, I get in the study to I was I was really happy about that as well. Ava came off of insulin within two weeks of taking the globe, your eyes is still on your reality. But it wasn't an easy process. It wasn't like just start taking a pill and come off insulin. You have to wean yourself off of it. She she had a difficult time she was low. Miss the time like in the 30s. It would take hours to come up I've had to like leave work and pick her up in school and Then you know, at night she'd be, you know, 400 and, and it was kind of like being in that first diagnosis stage all over again with CGM going off and we got her regulated and she's great. Her A1C was just recently like 6.2 I'm sorry. 6.9 she corrected me. I'm sorry. 5.9 Her A1C was 5.9. Yeah. She responded immediately to it like a one See, Why's she was down. Within two weeks of coming off of insulin. Her agency was down into the under seven,   Stacey Simms  26:38 right and this 5.9 is now what two years later?   Kristin Skiados  26:41 Yeah.   Stacey Simms  26:43 And what happened was you did what did you get that phone call? What was that? Like?   Kristin Skiados  26:48 I got a call from Dr. Street in February I think was right around Valentine's Day. And you know, she called and told me that I had the same mutation and It was, you know, once again that see it was like hitting the lottery. It was just something I couldn't believe I was hearing, you know, and of course, you know, the emotions come into play with it. And I thought when she was diagnosed with diabetes, I felt incredibly guilty that I had passed this disease on to her. And now when I look at it, I am so happy that if I pass anything on to her disease wise, thank goodness it was this because if she could still be on insulin, I could still be on insulin. And we're off and it's, it took me about a month to come off of insulin. I had a couple things working against me in this process. First off was my age. I was in my 40s to I think that oldest documented patient in literature was about 36. Oh, so there's a quite a bit of an age difference there. And plus I had died. I was on insulin for 38 years. Compared to another documented case, I think where it was significantly less, you know, so that 90% success 10% failure was pretty heavy for me because I wasn't necessarily responding to the medication as quickly as Ava did. I was kind of not having any lows. And I think Finally, like when I had my first low, I think I was in my classroom teaching, and my students were like, you know, what's wrong? I said, My blood sugar's low. And they're like, Oh, yeah, what do we do? I go, nothing. This is great I with them, because my students had kind of followed me and Ava kind of through this process. And I was like, No, this is I need this to be low. And then it took me about a month I came off of insulin essentially, it was April 28, is when I came off of insulin and I just had my A1C done, and I'm 6.5 Right now, and I take my glyburide twice a day Ava takes it three times. I know that my endocrinologist at Hopkins was shocked that I had a form of monogenic, and he's pretty keen on picking up things like that. But he said with my particular mutation, to KCNJ11. Geez, it mimics type one. And it's harder to identify a KCNJ 11 compared to that of a of a type one because they do mimic each other.   Stacey Simms  29:34 Let me stop you just for a second. Toni. I have so many questions. I think you know, my first reaction as a mom of a kid with type one, it goes back to this first days where we're all thinking, couldn't this be something else? Isn't there another possibility? And I remember find it I found MODY and I found other types of diabetes and I asked my endocrinologist and he said, Stacey, I really wish That he could just take a pill, but this is type 1 diabetes. So am I now supposed to go back or all the parents and individuals with type one listening to the podcast? What are we supposed to do? Should we go back and demand these tests?   Dr. Toni Pollin  30:15 So this is the really hard thing. So a couple things. One of the things that I do worry about and kind of want to temper is that, you know, of course, most people with a diagnosis of Type 1 diabetes actually have type 1 diabetes. And the the study that Ava and then Kristin were in the purpose of that study was really to find a realistic way to make sure not that necessarily every person with diabetes gets tested, but that every person with diabetes gets considered as a possible candidate based on certain red flags that clue you in so there is more overlap, I think that people realize and how people with different types of diabetes present and the resist study done. I sort of always knew this anecdotally, I come at this from kind of a unique perspective. I trained as a genetic counselor, and then went to Winton, and became did research and did a PhD studying the genetics of type two diabetes. And I realized that we had a lot of things we were promising about what would happen when we understood the genetics of type two diabetes and realizing that actually, with some of these monogenic forms, if we could just find the patients, we could already make a difference in their lives. And so I began to realize that it just often wasn't considered, or it was considered so rare, as long as not to exist. And then in 2012, there was actually a study published that was a study called the search study where they were trying to find all the diabetes, what caused diabetes and in a whole bunch of children at different centers in the country, and they found that you know, at least 80% of the time or more monogenic diabetes or specifically MODY is misdiagnosed, as either type 1 diabetes or type two diabetes, it can be mistaken. There are clues that you can look for. So how did Ava and Kristin end up in our study, when you know their own doctor didn't suspect them? So one of my team members I happen to have on my team, a mate, I'm not sure she may be the only physician who's double board certified in both endocrinology and medical genetics. And as one of our strategies, we had several strategies for identifying patients and trying to find ways of identifying patients and medical systems. One was using questionnaires to have simple questions for the red flags I'm about to tell you and also getting referrals. But also she just started she started to actually look up in the charts of patients who were coming for treatment for their next appointment to look for these red flags. So the one of the red flags we were looking for was children who are diagnosed before the age of 12 months, because we actually know that if they're if you're diagnosed before the age of six months, which is very, very Rare, the overwhelming majority of those cases are monogenic and not type one. It gets more and more likely to be type one as they get older, but the sort of gray zone, one of the things we were looking for was any children diagnosed before 12 months. Well, Dr. Street and saw Ava was coming in, she was diagnosed at 15 months, it was kind of Gee, isn't that you know, that's, that's pretty young. That's kind of borderline, you know, you sort of the line kind of creeps up, because you want to make sure you don't miss anybody. Then when we realize too, that, as Kristin pointed out that her mother also had type 1 diabetes, even though it's diagnosed with a little over age, that raised the suspicion. So that's actually one of the things they look for is when you see type one being transmitted from generation to generation, it happens and there's definitely an increased risk of children. But if it's monogenic, then the risk is more like 50%. So those are one of the things what's really important is that if it's type 1 diabetes, usually not always, but usually there are antibodies that indicate the autoimmune process. That says that the beta cells are going away, they're being destroyed by the immune system. But you have, especially the right antibody tests, and you don't have those antibodies, that's a red flag, it could still be type 1 diabetes, but when you get anybody's tested and you don't have them, then it raises the chance. The other thing is that the longer the C peptide persists, that also raises the suspicion because you know, C peptide, is a measure of whether the pancreas is actually producing insulin which you can measure even if a person is taking insulin injections, because it's it's the kind of byproduct of insulin that's produced by the body. Those are the kinds of things they look for sometimes somebody is we also look for people this has a really good likelihood of picking people up people who are diagnosed with diabetes, but it's not type 1 diabetes, like it's somehow it's known not to be type 1 diabetes, says Lena we might see some diagnosed with Type Two Diabetes at 25. Especially especially person is not overweight, not obese. So there's just see these sort of a typical situations that raise the suspicion. So you know, there's these characteristics. And we turned out that was our best characteristic for picking people up diagnosed with non type two diabetes and then we can non type one, then we confirmed it by looking at the antibodies and C peptide, then got hits is just, if you think about a physician who sees thousands of patients with diabetes, they're going to start to kind of notice like this one really looks a typical. So people start, you know, just noticing something a typical and sometimes it didn't always fit with the exact characteristics that we were looking for. But it almost fit and it sounded like it could be it sounded like you know, basically this is, you know, a child who maybe doesn't really need insulin. I mean, there are cases published there's an actual case report published of adolescent rebellion leads to diagnosis of monogenic diabetes because a teenager decided to stop using his insulin and was fine. And so they suspected. So I think earlier when you asked about, you know, what's the consequence of being on insulin when you don't need to be, I thought you might also ask, you know, why is this? Why are so many people you know, not correctly diagnosed. And that's it that there's some people not knowing about it. But then even if people know about it, then there's a lot of overlap. But there are these things you can do. There's a way you can put out links, but we've started to develop resources to help those patients and providers to start to think about it. And there's a website at the University of Exeter, where they have a calculator, where you just put in really basic information like hva watse. And whether you have a parent with diabetes, and it actually gives you based on their own database, the percent chance that someone you know, might have a mutation in one of these genes. But you know, as you can hear, no matter what you do, it's just not always straightforward. And that's what we'd like it to be.   Stacey Simms  37:00 I just and this may sound very ignorant, so pardon me, I can't wrap my brain around the fact that we're all supposed to be so careful with insulin, right? And people are terrified to, you know, to give too much. And yet you got 4% of people with diabetes who don't need insulin necessarily, who are taking it every day and not having these terrible adverse effects. I guess my question is, I'm almost more confused. I might. So not everybody is supposed to get into the testing, but you could be taking 40 units of insulin a day, and have monogenic diabetes, not need the insulin and not know it.   Dr. Toni Pollin  37:38 Right. So when I say not everybody should get genetic testing. I should probably rephrase that if there were a way and I believe there will be in the future for everybody to have genetic testing, then it would make sense got it, people if you know, I'll probably a lot of your listeners are, you know, podcast listeners are probably listening to some of these genomics podcasts. And you know, we're we're now at the point where more and more people have their whole genome sequenced in many of our kind of visions of, you know, what is genomic medicine look like, people often talk about, oh, I want to, I want to have genetic testing to see what I'm at risk for, I want to have my genome sequenced to see what I might risk for. But what I see is in the future, when everybody has access to their genomic data, then it could just become a very routine thing, where, you know, you get diagnosed with diabetes, and they run a bunch of tests, because forgetting about MODY, there's still tests to run to figure out what kind of diabetes you have, if you're, you know, if you're kind of on the border, if you're 29 years old, you're a candidate for type two, your candidate for type one, especially if you're, you know, if you're overweight, you know, some of these other risk factors. So in my dream, everybody has very ready access to their genomic data. And so so if somebody is diagnosed with diabetes, then you'll be able to run an algorithm that will pull up whether there are variants in any of these genes. It's just that we're not there yet, and it's still, there's still costs associated with doing genetic testing. So what we are needing to do right now kind of till we wait till the genome era is that we really need to pay attention. I think a lot of what we need to do is, is we need to, I think stories are the key. So that's why I was so excited to come on here with Kristin and Ava. Because I think that every story is different. And I got interested in this, for the reasons I said that I realized that there was a way that genetics could be used to help. And I A lot of what I knew was just from reading journal articles, but as I got started, you know, got funding for research and started doing the research and started talking to patients, I kept learning more and more nuances. And so I think one of the keys is just finding out I think there's a whole lot to this that we don't know because we don't know the full extent of the patient lived experience, but when we do that will help us to help other people.   Kristin Skiados  39:51 I would have never known I was a monogenic diabetic, had it not been for Ava because my people Parents don't have diabetes, there is zero history of diabetes in my family. So if it weren't for Ava, having diabetes, I would still be on an insulin pump and I would still be taking insulin and probably spend the rest of my life on insulin. So I'm very grateful, of course to my daughter for having diabetes is a weird thing for a parent to say. But when you when you look at, you know, the scope of kind of what's happened in our life and what and how we went from, functionally a pancreas that's because that's what our life had changed to, we kind of stopped being human, and we started being in Oregon. And there's not too many chronic diseases out there where you actually have to do the job of the organ that isn't working. And that's and that's what diabetes is and you become your band, forget, you know, but manipulating the pump and the shots and everything. To go from being a pancreas now to being a person, again, it's a pretty amazing thing. But once again, my position that I was type one the whole time. So if it weren't for Ava, being in the study, this would not be in my life today, being insulin free and on medication. hopefully at some point, people will have access to their genome to identify things like this so that you know, another person doesn't spend 38 years of their life taking insulin when they don't need to.   Unknown Speaker  41:40 You're listening to diabetes connections with Stacey Simms.   Stacey Simms  41:45 Much more to come. We will continue with our talk. The second half of the interview is coming up, including my chat with Ava, Kristin's daughter, and I want to let you know that if you're thinking what are my chances, what are my child's chances of actually having managed genetic diabetes, there's a short quiz you can take to see if it is worth talking to your doctor about this. And I am going to link that up on the episode homepage. It's just a couple of questions. I took it and really doesn't seem like it is worth it to talk to our doctor, but you can take it for yourself and find out more diabetes Connections is also brought to you by Dexcom. And you know, we started with Dexcom back in the olden days before share. So trust me when I say using the share and follow ups makes a big difference. And I'll tell you how long ago we started. We were cleaning out some things and Benny came running into my room and he's like, remember this and it was the share cradle. That's what for you new people. That's the only way we could share for a little while was plugging the Dexcom receiver into the share cradle. But you know, it makes such a big difference when you can see those numbers right. And you have to set parameters, at least we do about what I'm going to call him how long to wait. You know not to overreact to everything. It really helps us talk and work about diabetes less if you had a sleep over or away on a trip, it gives me so much peace of mind. And I really like that I can troubleshoot with him, because we can see what's been happening over the last 24 hours. And not just at one moment. Internet connectivity is required to access the separate Dexcom follow app. To learn more, go to diabetes, connections calm and click on the Dexcom logo.   Time for Tell me something good. And I got a great message via Facebook from Christina and she writes, “I have a good news story for you. My older daughter Natasha, who is 24 has been a great help to her younger sister rose, six rows was diagnosed three years ago. And Natasha has been there for everything. The hospital stay the classes and everything in between. She is busy with her own life, but always had time for us and her little sister because of her sister who has type one And her brother who has Crohn's, she is getting her master's degree to become a dietitian.” Christina, thank you so much for sharing that. Thank you for the great picture that we will share on social media. You know, we know that any chronic condition is tough on the family, and it's tough on the siblings who don't have it, right, because everybody's life is affected. It is hard stuff to go through and make the siblings feel included. They get so much empathy and understanding, but there's can be a lot of resentment and normal bad feelings, too. I think it's important to acknowledge that. So I really appreciate you sharing this and all the best to Natasha, she goes forward in her studies Keep us posted. And Christina also added and I'll put the city but that's very self promotional. But Christina added that “I want to tell you how much I appreciate you and your podcast. So many times. I feel like I'm living in my own world with this crazy diabetes. I listen, and I instantly feel better. Thanks. Keep up the great work.” Well, Christina, you just made my day. Thank you so much. For that, you know, I gotta tell you, it's so selfish to do this podcast because I do it and I instantly feel better. It's really just a nice way for me to be connected to the community. It's really it's not a one way street here. So thank you for that very, very nice note. All right, let's get back to our talk on moto genetic diabetes. This is the second half the interview, and we're going to pick up here with a few words from Ava, who was initially diagnosed as a baby. But a study found that at the age of nine, she didn't have type one at all. And I want to let you know here, she talks about her insulin pump and her elementary school experience. And while everyone is different, you'll understand in a moment why I'm saying this, but this did not match our experience at all. And I think it's really important especially if you are newer to an insulin pump or considering one for you or your child, that if your child is being excluded, or cannot do certain activities with an insulin pump, or is being told they cannot. The staff at that school needs better education and It's a great idea to talk to your educator or your endocrinologist or even your pump Rep. To say, my child can't do this with this pump. How do we work around it? Because as you know, if you listen, having a pumps and stage two with tubes, pumps, and he never stopped my kid from doing anything. All right, so let's pick it back up. And here I am. I am talking to Ava, when your parents told you that you actually didn't have type one. But you had something else. Do you remember what you thought about that?   Ava Skiados  46:29 I thought that it was worse, because my mom just told me that I didn't have type one, but I thought that it was a lot worse.   Stacey Simms  46:38 And then they explained that it was good, just going to be different. And did you feel better about it pretty quickly.   Ava Skiados  46:44 I yeah. It took like an hour before they told me that I just fell off of insulin.   Stacey Simms  46:51 Do you remember? So it's been about two years. I'm curious if you remember what it was like to take insulin and where an insulin pump   Ava Skiados  47:00 actually change my site every three days. And when I had to wear the pump, I had a cord. And it got stuck on things. And I couldn't do much physical activity or I could, but like I couldn't do certain things in gym, because it was off the little hack that connected to my catheter, or my pump was all about and a disconnect that way. So I couldn't do many things that other kids got to do. So just kind of like left out and sitting on the lawn, Jim.   Stacey Simms  47:36 Oh, well, that stinks. Tell me what you do. Now, you don't wear an insulin pump. You take a pill a couple of times a day.   Ava Skiados  47:43 I take the post three times a day. And every except for the fact that I can do more things that I couldn't do. I can go without I can just do Without leaving, as my mom can get a card calculated is this and I need to put it into my   Stacey Simms  48:09 your mom talk about what it was like before cuz you know she thought you had type one also?   Ava Skiados  48:16 Yeah, I don't talk about it. No one really brings it up. But if someone brings it up and asked me like how it was before I came off as one. I don't really like to talk about it but I can stuck with how I was before. Grab your eyes.   Stacey Simms  48:34 Do you mind me asking why you don't like to talk about it? It's okay if you don't even want to answer that.   Ava Skiados  48:39 Because I couldn't do a lot of stuff in school. When I was in like third or fourth grade, that's when I finally come off. But when I was in kindergarten through about third or fourth grade, I couldn't really do the last one. I couldn't do many, like I it was hard to do a play that I was it. They had a microphone and my side too, but it always got to hold on to the microphones. We had to readjust it regularly.   Stacey Simms  49:17 Have you sat down and talk to each other about how extraordinary this all is? Because it's hard I think when you're the people in it to see.   Kristin Skiados  49:26 Well, you know, when we were presented with the study option, you know, they thought like, Oh, we have to go we have to get blood drive. She was like, No, I don't want to do that they go you know, but you have to understand not only can this help us but you know, it can help other people and really, when we started getting involved with Dr. Poland through med rapid going to the French for life conference that you know, I totally event that, you know, what we're doing is helping other people. We're giving other people People the potential opportunity to experience life without insulin. And that's the beauty of medical research. And I've done a lot of different and participated a lot of different research studies, where, you know, we kind of get to see the outcome of that. And I and there's an intrinsic value to doing things like this and to talking about it tends not to talk about as much as I do. But yeah, like we've, you know, we've talked about, you know, why we're doing this, and you know, why we're doing the podcast and why we went to Florida. And that was one of the most fantastic diabetes conferences I've ever been to, and why we're sharing our stories because there's other people out there like us, and you know, she's 11 and, and she's in her little 11 year old world, and I'm not sure she really kind of sees, you know, the outcomes of what we're doing. I don't think she's going to really realize that until she's a little bit older. See, wow, you know, there's people in my high school that have monogenic it, you know, when she I think she begins to meet other people that have a form of monogenic? You know, when I was type one was diagnosed with type one, I was the only person in my town. And I was one of only like nine kids in northeastern Pennsylvania with Type 1 diabetes. So talk about being kind of your own being in a community. Everyone knew I was diabetic at the age that I'm at now and I'm a teacher. Every year I have the diabetic kids, they put them in my class, I think the conventional other diabetics, put them with sciatica, pain, you know, and even got a couple kids in her class that are type one, you know, and so you kind of feel that you're not alone, that you're not just this person with this one illness that, you know, doctors, you know, can treat but it's hard to manage. And I think that as we're moving forward with the research that Dr. Poland is done, that There's going to be a shift where Ava is not going to be the only monogenic, diabetic patient or kid in her school, or in our county, you know, or in Southern Maryland as a whole. Hopefully we'll see. There's more kids out there that had been re diagnosed with a form of monogenic. So we talked about it in terms of the value of it, but I think for an 11 year old, it's a little bit harder to grasp the big picture. When you're still the only kid in your school that monogenic, she's not the only diabetic, but she's the only monogenic kid. You know, when she started Middle School, we had to have a meeting with the administrative team and the nursing supervisor because they didn't know any of this stuff.   Stacey Simms  52:49 Well, wait, let me jump in. Because I know we're getting really long on this interview guys, but I may have misunderstood so she takes a pill three times a day, but does she have to do anything else? Are you still checking blood sugar and worried about highs and lows   Kristin Skiados  53:00 So you we are we have any we still do worry about her highs and lows. So I mean, if she's high, it will come back down when she's low. Yeah, we still have to treat it, you know, 15 grams of carbs. We still have that protocol. She wears a CGM most of the time. So she really just kind of checks in with her nurse and she has to take her glide right at lunchtime. So she visits the nurse there. But you know, when you're dealing with something that's not the norm, people get a little bit nervous with it.   Stacey Simms  53:31 All right, before I let you go and Toni, let me ask you to weigh in on this one more time. I just keep coming back to what do we do? I know that in the future, hopefully we can get more testing. But is it a question now of Okay, my son was dead. Let's use me. My son was diagnosed at 23 months. He looks like classic type 1 diabetes. No one in our family had diabetes before him. I don't recall. You know, not needing Insulin at any way, shape or form. In fact, he's had that classic journey of teeny tiny doses. I remember growing up those quarter units in a syringe, we couldn't see it at all when he was 23 months, and then the basal rates doubling and then doubling again as he hit puberty. So I think we're probably not a good candidate to be tested for this. Right? It certainly   Dr. Toni Pollin  54:21 sounds like classic type one, I should do my kind of disclaimer now that I'm not a physician. But, you know, I think part of the problem is that we still don't know what we don't know, which is why what we were telling people you know, when we've now we've been to Kristin and Ava and I were mentioned at Florida Kristin and I went to the friends for life conference recently, more recently in Falls Church and just the importance of getting those antibodies and the C peptide, because you know, to be No, I think it's becoming more routine to get them. But just because it's possible to even the C peptide, it's possible to not show When you see peptide in the blood because this particular type, so the type that Kristin and Ava are have is actually different than the main types they talked about, where you know, the insulin gets made, but there's this channel that doesn't function properly, and so the insulin can't get out. So I say, look for the typical cases. But if you have any doubts, if you're curious, at least make sure you've kind of had these these kind of baseline measures that make it clear that this really is type 1 diabetes, because we don't know every possible scenario that this can present as I also did want to say, because I wanted to kind of correct something a little bit you were asking earlier, you know, is there harm to being on insulin when you don't need it? I can tell you that this KTP diabetes is potassium channel diabetes. It's most common in you know, really little infants, like we're talking like zero to six months. And I've heard some of those parents, for example, there's a little girl in Chicago, who's actually in a movie called journey to a miracle if you know Educational Resource and her I've seen her parents speak and talk about how she would have hypoglycemic seizures because it was very difficult to control her in her glucose with insulin, especially when she couldn't verbalize what was going on inside what really struck me I went to actually the the premiere of the of the movie they made when they showed it in Chicago. And actually, I think this movie is available on Amazon. So if people want to see it, it tells some of the story but what really struck me was these parents many of these parents saw this as a cure, which kind of surprised me because I thought oh, we don't have a cure but it's better but it to them it felt like going from a kid with a with really difficult to control Type 1 diabetes to you know, manageable, mild type two diabetes like the other thing I should this is kind of really bringing up a whole nother subject but some of the kids who have these mutations it actually affects it has it has neurological function and actually affects some of their brain function and some of that can improve with the treatment as well. So that's just kind of extra, but kind of getting, you know, back to your question of what do we do? This is what's keeping me keeps me up at night sometimes, but it's keeping me in research. This is this is what my research is really trying to do. How do we address all these barriers? I mean, we've talked about some of the barriers, genetic testing can still be expensive. We need to communicate to insurance companies what the genetic testing does and how it's useful. We need to communicate to providers worldwide, when we do the genetic testing, we need to improve the dinette testing. So there are better at telling the difference between which variations in the gene actually cause diabetes. And so one of the other issues that I have is I have a worldwide panel of experts in monogenic diabetes that can pull together not only their knowledge, but they can pull together their cases. So to give an example, the mutation that Ava has, was only reported one time in the literature and because it was recorded in the literature. We were able to say that it was an important mutation in this disease, otherwise we wouldn't have been able to. And so the solution really is communication. That's why we're here on this podcast. And people telling their stories, working together, being open and finding more people so that other people can help come up with other creative, creative ways. So   Stacey Simms  58:22 well, Toni, and Kristin and Ava, thank you all so much for sharing this story for giving us all of this information and for continuing the research. I mean, it's incredible to think about how many people might be walking around with a misdiagnosis. So thanks for coming on. I appreciate your time so much and you know, keep us posted. How about that? Isn't it difficult to think about being misdiagnosed and not having type 1 diabetes? I mean, as Kristin said, it really is a dream. It would be so nice to be able to tell my son Oh, sorry. You don't need to take insulin anymore. There were times during this interview where I kind of felt myself getting I got jealous. I got a little angry. I got resentful. I was very happy for them. I'm happy for any family that that, you know, turns the situation around. Although it doesn't sound like monogenic diabetes is a walk in the park either. I mean, let's be honest, but I had to let myself feel those feelings as we were talking. And if you felt them too, you're definitely not alone. Okay, next stuff on the world verse diabetes mom book tour. I'm heading to South Portland, Maine this weekend. Oh, it is gonna be so much colder. I'm so nervous being the southern transplant that I am. It's gonna be great. I'm talking to a group called the main pea pods, parents and providers of diabetic children. And I am thrilled to be going up there so excited to talk to this group and meet everybody. We're gonna have a great weekend. If you'd like me to come speak to you definitely reach out there's a page at diabetes connections. com called Community It's got our schedule where we're going, where we've been and what you need to do to request an appearance from me. I can come out and do the podcast, I can come out and do what I'm doing this weekend, which is the world's worst diabetes mom presentation, which is all about why you all should be more worst. Making mistakes is a really, really great idea. We have a lot of fun. Thank you, as always to my editor john q. kennis. From audio editing solutions. Thank you so much for listening. Our mini episode is going to come along and just a couple of days. Those are airing every Thursday. So I hope you can join us for that. I'm Stacey Simms, and I'll see you back here on Thursday.   Unknown Speaker  1:00:43 Diabetes Connections is a production of Stacey Simms media. All rights reserved. All wrongs avenged   Transcribed by https://otter.ai

In this episode, we answer a reader question about her low T3. Kelli's case is a bit complicated, but it sheds light on how important it is to address low T3 levels.  We get this question all the time about the thyroid hormone, T3. Many will say, ‘my free T3 levels are low, but my doctor will not do anything about it'. We wanted to talk about low T3 and how there are many factors that can cause a low T3.  Also on ways to increase your T3 conversion as well as some medications for low T3. We are also going to touch on autoimmune diseases such as Hashimoto's, Type I diabetes and Celiac disease. Question from Kelli: My thyroid labs are all within the normal range, but I FEEL so depleted. My free t3 has never tested above 2.3. I have T1D and Celiac disease already. I know my body is prone to be difficult and function lower on some levels than most. How can I fix my free t3 if it is low and if the doctor says it's not “treatable low.” One of our most popular blog posts is, ‘Low T3 levels”.  This partly why we wanted to talk about Kelli's concerns about her autoimmune diseases and her low T3.  Kelli is one of a common predicament that we see all the time. Having low levels of FreeT3 but her doctor says it's not treatable or just ignores it.  Low T3 levels are very much treatable and should not be blown off. We really like Kelli's questions because she also has Type One Diabetes (T1D) and Celiac disease.   T1D is considered an autoimmune disease and shouldn't be confused with Type Two Diabetes.  T1D is where the immune system will attack the insulin-producing cells in the pancreas. So the pancreas cannot release insulin in response to elevated levels of blood sugar.  Type One Diabetes is considered, insulin-dependent and most likely diagnosed before the age of 20. Kelli also has Celiac disease which is an intolerance to gluten.  In the small intestines, there are little finger-like projections called microvilli which is what absorbs what we have eaten.  Think of it as a long carpet/rug. You then squish up the rug together, so there are many undulations. This increases the surface area tremendously, and then there is more area to absorb nutrients.  In celiac, because of the immune reaction to gluten will cause terrible damage to the microvilli. Causing the villi to erode consequently causing many symptoms including malabsorption and malnutrition. If Kelli has T1D and Celiac and Low T3 levels she very well may have Hashimoto's. Hashimoto's is a condition where the immune system creates antibodies attacking the thyroid and eventually causing lowered thyroid function. Hashimoto's can be similar to celiac.  There is a sensitivity to gluten in Hashimotos that patients do much better on a gluten-free diet. Hashimoto's is similar to celiac bc gluten needs to be eliminated to reduce the Hashimoto immune response.   Let's back up a bit and explain about thyroid.  The thyroid gland secretes mainly T4. T4 will travel in the bloodstream and convert to T3.  Free T3 is the active form of thyroid. Even if you have perfect levels of T4 but low T3, then you could have symptoms of low T3.   Doctors really don't know what to do if the T3 levels are low.  A lot

For years, type two diabetics have been treating themselves with insulin injections and other medications. The medical team at Virta Health has introduced a new method to not only treat type two diabetes but potentially reverse it: a low-carbohydrate diet.

Betsy was diagnosed as morbidly obese and with type two diabetes at the age of 30. By the early 2000s, she weighed close to 400 pounds. In 2011, she made the decision to change her life and reclaim her health and she's sharing her story with us on the show today. Betsy tells us about how she got into ultrarunning, how she ultimately reversed her type two diabetes, and the work she's doing now to spread what she learned on her journey. Get full show notes and more information here: https://notyouraveragerunner.com/68

Childhood obesity is rising so are rates of Type Two Diabetes and early signs of heart disease. Loraine Ballard Morrill speaks with Jeff Long, President and Founder of Healthy Kids Running Series who has created a fun and affordable 5 week program that introduces children to running and healthy living. http://www.healthykidsrunningseries.org/When families lose a loved one to a violent crime – they often don't understand how to navigate the criminal justice system and know how to access the resources of victim services organizations. That's why Roz Pichardo founded Operation Save our City. She turned her own experience losing a brother to a shooting and almost dying herself after a brutal attack to help homicide victim families. There will be a fundraiser for her organization on September 27th 4-6 pm at 1746 N. Howard Street in Philadelphia. For more info on this and Operation Save Our City check out the Facebook page. https://www.facebook.com/OperationSaveOurCity/?tn-str=k*FWork Ready student intern Noor Bowman interviews Rich Sedmak of Schoolyard Ventures which helps teens launch businesses, non-profits and other real-world projects that are meaningful to them. https://www.schoolyardventures.com/

Childhood obesity is rising so are rates of Type Two Diabetes and early signs of heart disease. Loraine Ballard Morrill speaks with Jeff Long, President and Founder of Healthy Kids Running Series who has created a fun and affordable 5 week program that introduces children to running and healthy living. http://www.healthykidsrunningseries.org/Philadelphia's Asian Arts Initiative was founded 25 years ago by Gayle Issa to promote the arts are an avenue for not only creative expression, but community building and intercultural awareness. Loraine speaks to newly appointed Executive Director Anne Ishii and her forward looking vision for the organization to realizing community impact through arts and arts practice. http://asianartsinitiative.org/Loraine is joined by Philly Gay Lawyer's Angela Giampolo for a once a month segment called SpeakOut which addresses issues impacting the LGBTQ community but have relevance to all. In this edition - an interview with Jake Yoblonski - CEO Platinum Brands about the rewards and challenges of LGBTQ businesses. https://platinumbrands.com/

Childhood obesity is rising so are rates of Type Two Diabetes and early signs of heart disease. Loraine Ballard Morrill speaks with Jeff Long, President and Founder of Healthy Kids Running Series who has created a fun and affordable 5 week program that introduces children to running and healthy living. http://www.healthykidsrunningseries.org/

It's an Ask the Mentors Episode! 1.  Lecture Suggestion for Type Two Diabetes group who are all Paleo.  2.  Best protocol to clear estrogen dominance, and for gut lining repair? 3.  Client Case: G.I. test results came back positive for Blasto (levels are indicative of active infection), Klebsiella, Candida. Recommended protocol 4.  Caller: story of receptive friend and talking FDN 5.  Did biomatrixone.com stop carrying bezweken and start with their own line of BHRT drops? Is there some training or just call their clinician? 6.  Are glandular products such as adrenal support - bovine glandular and thyroid support - porcine or bovine considered an enhancing products in terms of WADA for professional athletes? 7.  Any contradictions for collagen intake for colon cancer patients? 

Loraine Ballard Morrill speaks with Missy Rearson Nurse Practitioner at Children's Hospital of Philadelphia about Type One and Type Two Diabetes and new development in treatments.

For decades we’ve heard that diabetes prevention is simple—lose weight, eat less, and exercise more. But something is wrong with the conventional wisdom. Nearly 115 million people live with either diabetes or prediabetes in the United States, and that number is growing. It is time to reverse this trend. Virta was founded in 2014 with the goal of reversing diabetes in 100 million people by 2025. They have made this possible through advancements in the science of nutritional biochemistry and technology that is changing the diabetes care model. James McCarter, MD, PhD, is Head of Research at Virta, and in this interview, Dr McCarter explains how Virta is using a combination of a very low carb, ketogenic diet together with 1-on-1 health coaches and some sophisticated machine learning techniques to predict sentiment in natural language and spot anomalies in blood biomarkers. After the recording was made, Dr McCarter realised that he was off by about a decade on Joslin. Rather than 1920s, Dr. Elliott Joslin actually began keeping a diabetes registry early in the 20th century and published The Treatment of Diabetes Mellitus in 1917.  “Joslin carried out extensive metabolic balance studies examining fasting and feeding in patients with varying severities of diabetes. His findings would help to validate the observations of Frederick Madison Allen regarding the benefit of carbohydrate- and calorie-restricted diets.” Here’s the outline of this interview with James McCarter, MD, PhD: [00:01:00] Divergence, Inc. [00:01:43] Presentation: The Effects of a Year in Ketosis with James McCarter, MD, PhD at the Quantified Self Conference and Exposition. [00:02:44] Books by Gary Taubes. [00:03:13] Omega 3:6 ratios. [00:05:54] Rapeseed and Canola. [00:06:44] Wild Planet sardines. [00:07:11] The Virta story. [00:07:18] Sami Inkinen. [00:07:38] Study: SD. Phinney, BR. Bistrian, WJ. Evans, E. Gervino, GL. Blackburn, The human metabolic response to chronic ketosis without caloric restriction: preservation of submaximal exercise capability with reduced carbohydrate oxidation., Metabolism, volume 32, issue 8, pages 769-76, Aug 1983, PMID 6865776. [00:08:48] Jeff Volek, PhD, RD on PubMed. [00:09:51] Fear of fat. [00:10:13] USDA dietary guidelines. [00:12:59] The goal is to reverse T2D in 100M people. [00:14:09] Study: NCD Risk Factor Collaboration (NCD-RisC). Worldwide trends in diabetes since 1980: a pooled analysis of 751 population-based studies with 4·4 million participants. Lancet (London, England). 2016;387(10027):1513-1530. doi:10.1016/S0140-6736(16)00618-8. [00:14:29] Joslin Diabetes Center. [00:16:37] The causes of T2D. [00:17:35] Calories are now more accessible. [00:18:22] Sugar and refined carbohydrate intake. [00:20:26] Prerequisites for the Virta program. [00:22:19] Telemedicine, health coaches, online nutrition and behaviour education, biometric feedback, peer community. [00:23:53] Getting off meds. [00:24:50] HbA1C > 6 or glucose > 120 mg/dL [00:25:32] Purdue University. [00:26:28] Podcast: Econtalk: Mark Warshawsky on Compensation, Health Care Costs, and Inequality. [00:29:02] Study: American Diabetes Association. Economic Costs of Diabetes in the U.S. in 2012. Diabetes Care. 2013;36(4):1033-1046. doi:10.2337/dc12-2625. [00:29:27] Study: McKenzie AL, Hallberg SJ, Creighton BC, Volk BM, Link TM, Abner MK, Glon RM, McCarter JP, Volek JS, Phinney SD. A Novel Intervention Including Individualized Nutritional Recommendations Reduces Hemoglobin A1c Level, Medication Use, and Weight in Type 2 Diabetes. JMIR Diabetes. 2017;2(1):e5. [00:30:45] Discontinuing 2/3 of the meds. [00:32:54] Health coaching. [00:34:18] Behaviour change. [00:35:30] Biometrics, blood BHB. [00:38:10] Reducing blood pressure and CRP. [00:38:30] Study: Youm, Yun-Hee, et al. "The ketone metabolite [beta]-hydroxybutyrate blocks NLRP3 inflammasome-mediated inflammatory disease." Nature medicine 21.3 (2015): 263-269. [00:39:49] Blood levels of BHB and weight loss. [00:41:36] STEM-Talk #43: Jeff Volek Explains the Power of Ketogenic Diets to Reverse Type 2 Diabetes. [00:43:33] Machine learning. [00:45:57] The Team at Virta including Nasir Bhanpuri, Catalin Voss and Jackie Lee. See article Will robots inherit the world of healthcare? For links to their talks. [00:46:49] Random Forest. [00:47:06] Nourish Balance Thrive 7-Minute Analysis. [00:48:05] Natural Language Processing. [00:48:57] Nourish Balance Thrive Highlights email series. [00:50:26] Finding purpose in your work. [00:51:59] Using machine learning to change behaviour. [00:53:25] Book: Hooked: How to Build Habit-Forming Products by Nir Eyal. [00:54:11] Podcast: How to Avoid the Cognitive Middle Gear with James Hewitt. [00:55:37] $400 per month for one year. [00:57:58] Blog Post: Does Your Thyroid Need Dietary Carbohydrates? By Stephen Phinney, MD, PhD. [01:00:21] Article: Understanding Local Control of Thyroid Hormones:(Deiodinases Function and Activity) and Podcast: The Most Reliable Way to Lose Weight with Dr. Tommy Wood. [01:02:12] Podcast: How Busy Realtors Can Avoid Anxiety and Depression Without Prescriptions or the Help of a Doctor with Douglas Hilbert.

http://www.cheftimothymoore.com, To A Diabetic Sugar Is The Drug Of Choice.  The issues that we face as diabetics is being truthful to ourselves. The disease type 2 diabetes can be prevented and reversed and it has been proven by my individuals who want to be free of diabetes. I understand that the hardest part is really understanding this disease TYPE 2 DIABETES and why it seems so hard to control or just reverse it. The main reason is our diet and in the podcast Chef Timothy Moore address why the impossible is possible. If you living with type 2 diabetes now you have support to help you in your walk to reverse you life log issue of Type Two Diabetes. The decision is yours only so today lets make the change to become diabetes free and take bake control of our life forever. The is a course created to help you one you way check it out with link enclosed. The Diabetes course here        

Prevention

Type two diabetes is the most common form and is growing dramatically. What is it, and what can be done about it?