Podcast appearances and mentions of Vivek Wadhwa

Welcome to part 2 of our special event, “The AI Competition: Public Policy Strategies”. The event, co-hosted by MIT Technology Review, brings together some of the leading voices in AI policy from the public and private sectors to role-play these complex issues. These AI leaders play roles in the US, China, and The EU, and enact policies that best align with their roles interests in the AI space. This episode contains the second and final phase of the game. We hope you enjoy this insightful episode.  Our Players: US Government Players White House (NSA, AI & Crypto Czar, Assistant to Pres. For S&T) - Doug Calidas, Senior Vice President of Government Affairs for Americans for Responsible Innovation (ARI) Government research institutions (funding) - Stephen Ezell Standards and governance (NIST, DOS, etc.) - Vivek Wadhwa, Adjunct Professor at Carnegie Mellon's School of Engineering at Silicon Valley Regulatory and trade (DOS, Treasury, etc.) - Susan Ariel Aaronson, American author, public speaker, and GWU professor Department of Defense- Daniel Castro, vice president at the Information Technology and Innovation Foundation (ITIF) Commerce Department - Anupam Chander, Scott K Ginsburg Professor of Law at Georgetown University Law Center Intel Community and Cyber Defense - David Mussington, professor of the practice the University of Maryland School of Public Policy, and currently serves as the CISA Executive Assistant Director Congress/State Department -  Cameron Kelly,  Distinguished Visiting Fellow, Brookings Institutution China players Central Military Committee representatives - Rohit Talwar, founder of FastFuture Intelligence and cyber - Daniel Richardson, President of Indepth Global AI  Public/Private Industry - Sarah Myers West, co-director at AI Now Ministry of Science and Technology (MOST)/Ministry of Industry and Information technology (MIIT) - David Lin, Senior Director for Future Technology Platforms at the Special Competitive Studies Project (SCSP) European Union Governance- Courtney Radsch, Director, Center for Journalism and Liberty at Open Markets Institute Military/Security - Gordon LaForge, senior policy analyst at New America Regulatory - Michelle Nie, EU Tech Policy Fellow at the Open Markets Institute Industrial and research policy - David Goldston, director of government affairs at the Natural Resources Defense Council Intelligence Agencies - Rumman Chowdhury, scientist, entrepreneur, and former responsible artificial intelligence lead at Accenture Civil Society  Large players (ChatGPT, META, Amazon, Microsoft) - Cody Buntain, Assistant Professor; Affiliate Fellow, UMD Honors College – Artificial Intelligence Cluster Medium players - Ramayya Krishnan, Dean, Heinz College Of Information Systems And Public Policy at Carnegie Mellon University Open-source communities - Jay Lee, Clark Distinguished Chair Professor and Director of Industrial AI Center in the Mechanical Engineering Dept. of the Univ. of Maryland College Park Advocacy Organizations - David Goldston, director of government affairs at the Natural Resources Defense Council  Legal Community - Kahaan Mehta, Research Fellow at the Vidhi Centre for Legal Policy  Universities and academia Large universities - Nita Farahany, Robinson O. Everett Distinguished Professor of Law at Duke Law Smaller schools - Anand Patwardhan, professor in the School of Public Policy at the University of Maryland Medium Universities - Elizabeth Bramson-Boudreau, CEO and Publisher at MIT Technology Review Government laboratories (Defense, DOE, etc.) - Emily M. Bender, University of Washington Professor This material is distributed by TRG Advisory Services, LLC on behalf of the Embassy of the United Arab Emirates in the U.S.. Additional information is available at the Department of Justice, Washington, DC. Learn more about your ad choices. Visit megaphone.fm/adchoices

Welcome to part 2 of our special event, “The AI Competition: Public Policy Strategies”. The event, co-hosted by MIT Technology Review, brings together some of the leading voices in AI policy from the public and private sectors to role-play these complex issues. These AI leaders play roles in the US, China, and The EU, and enact policies that best align with their roles interests in the AI space. This episode contains the second and final phase of the game. We hope you enjoy this insightful episode.  Our Players: US Government Players White House (NSA, AI & Crypto Czar, Assistant to Pres. For S&T) - Doug Calidas, Senior Vice President of Government Affairs for Americans for Responsible Innovation (ARI) Government research institutions (funding) - Stephen Ezell Standards and governance (NIST, DOS, etc.) - Vivek Wadhwa, Adjunct Professor at Carnegie Mellon's School of Engineering at Silicon Valley Regulatory and trade (DOS, Treasury, etc.) - Susan Ariel Aaronson, American author, public speaker, and GWU professor Department of Defense- Daniel Castro, vice president at the Information Technology and Innovation Foundation (ITIF) Commerce Department - Anupam Chander, Scott K Ginsburg Professor of Law at Georgetown University Law Center Intel Community and Cyber Defense - David Mussington, professor of the practice the University of Maryland School of Public Policy, and currently serves as the CISA Executive Assistant Director Congress/State Department -  Cameron Kelly,  Distinguished Visiting Fellow, Brookings Institutution China players Central Military Committee representatives - Rohit Talwar, founder of FastFuture Intelligence and cyber - Daniel Richardson, President of Indepth Global AI  Public/Private Industry - Sarah Myers West, co-director at AI Now Ministry of Science and Technology (MOST)/Ministry of Industry and Information technology (MIIT) - David Lin, Senior Director for Future Technology Platforms at the Special Competitive Studies Project (SCSP) European Union Governance- Courtney Radsch, Director, Center for Journalism and Liberty at Open Markets Institute Military/Security - Gordon LaForge, senior policy analyst at New America Regulatory - Michelle Nie, EU Tech Policy Fellow at the Open Markets Institute Industrial and research policy - David Goldston, director of government affairs at the Natural Resources Defense Council Intelligence Agencies - Rumman Chowdhury, scientist, entrepreneur, and former responsible artificial intelligence lead at Accenture Civil Society  Large players (ChatGPT, META, Amazon, Microsoft) - Cody Buntain, Assistant Professor; Affiliate Fellow, UMD Honors College – Artificial Intelligence Cluster Medium players - Ramayya Krishnan, Dean, Heinz College Of Information Systems And Public Policy at Carnegie Mellon University Open-source communities - Jay Lee, Clark Distinguished Chair Professor and Director of Industrial AI Center in the Mechanical Engineering Dept. of the Univ. of Maryland College Park Advocacy Organizations - David Goldston, director of government affairs at the Natural Resources Defense Council  Legal Community - Kahaan Mehta, Research Fellow at the Vidhi Centre for Legal Policy  Universities and academia Large universities - Nita Farahany, Robinson O. Everett Distinguished Professor of Law at Duke Law Smaller schools - Anand Patwardhan, professor in the School of Public Policy at the University of Maryland Medium Universities - Elizabeth Bramson-Boudreau, CEO and Publisher at MIT Technology Review Government laboratories (Defense, DOE, etc.) - Emily M. Bender, University of Washington Professor This material is distributed by TRG Advisory Services, LLC on behalf of the Embassy of the United Arab Emirates in the U.S.. Additional information is available at the Department of Justice, Washington, DC. Learn more about your ad choices. Visit megaphone.fm/adchoices

Welcome to a very different episode of Siliconsciousness. Today, we are taking a creative new approach to discussing the future of AI. This episode comprises the first part of our special event, “The AI Competition: Public Policy Strategies”. The event, co-hosted by MIT Technology Review, brings together some of the leading voices in AI policy from the public and private sectors to role-play these complex issues. These AI leaders play roles in the US, China, and The EU, and enact policies that best align with their roles interests in the AI space. This first episode contains the first phase of the game, as well as introductions from the editor in chief of MIT Technology Review Mat Honan as well as game controller Ed McGrady. We hope you enjoy. Our Players: US Government Players White House (NSA, AI & Crypto Czar, Assistant to Pres. For S&T) - Doug Calidas, Senior Vice President of Government Affairs for Americans for Responsible Innovation (ARI) Government research institutions (funding) - Stephen Ezell Standards and governance (NIST, DOS, etc.) - Vivek Wadhwa, Adjunct Professor at Carnegie Mellon's School of Engineering at Silicon Valley Regulatory and trade (DOS, Treasury, etc.) - Susan Ariel Aaronson, American author, public speaker, and GWU professor Department of Defense- Daniel Castro, vice president at the Information Technology and Innovation Foundation (ITIF) Commerce Department - Anupam Chander, Scott K Ginsburg Professor of Law at Georgetown University Law Center Intel Community and Cyber Defense - David Mussington, professor of the practice the University of Maryland School of Public Policy, and currently serves as the CISA Executive Assistant Director Congress/State Department -  Cameron Kelly,  Distinguished Visiting Fellow, Brookings Institutution China players Central Military Committee representatives - Rohit Talwar, founder of FastFuture Intelligence and cyber - Daniel Richardson, President of Indepth Global AI  Public/Private Industry - Sarah Myers West, co-director at AI Now Ministry of Science and Technology (MOST)/Ministry of Industry and Information technology (MIIT) - David Lin, Senior Director for Future Technology Platforms at the Special Competitive Studies Project (SCSP) European Union Governance- Courtney Radsch, Director, Center for Journalism and Liberty at Open Markets Institute Military/Security - Gordon LaForge, senior policy analyst at New America Regulatory - Michelle Nie, EU Tech Policy Fellow at the Open Markets Institute Industrial and research policy - David Goldston, director of government affairs at the Natural Resources Defense Council Intelligence Agencies - Rumman Chowdhury, scientist, entrepreneur, and former responsible artificial intelligence lead at Accenture Civil Society  Large players (ChatGPT, META, Amazon, Microsoft) - Cody Buntain, Assistant Professor; Affiliate Fellow, UMD Honors College – Artificial Intelligence Cluster Medium players - Ramayya Krishnan, Dean, Heinz College Of Information Systems And Public Policy at Carnegie Mellon University Open-source communities - Jay Lee, Clark Distinguished Chair Professor and Director of Industrial AI Center in the Mechanical Engineering Dept. of the Univ. of Maryland College Park Advocacy Organizations - David Goldston, director of government affairs at the Natural Resources Defense Council  Legal Community - Kahaan Mehta, Research Fellow at the Vidhi Centre for Legal Policy  Universities and academia Large universities - Nita Farahany, Robinson O. Everett Distinguished Professor of Law at Duke Law Smaller schools - Anand Patwardhan, professor in the School of Public Policy at the University of Maryland Medium Universities - Elizabeth Bramson-Boudreau, CEO and Publisher at MIT Technology Review Government laboratories (Defense, DOE, etc.) - Emily M. Bender, University of Washington Professor Learn more about your ad choices. Visit megaphone.fm/adchoices

How can Legacy companies transform themselves to compete with Startups? What lessons can be learned from the different ways legacy companies Microsoft and IBM navigated the new business landscape. What can we expect from the new tech hubs popping up around the world that aim to be a recreation of what makes Silicon Valley work?Vivek Wadhwa is an academic, entrepreneur, and author of five best-selling books: From Incremental to Exponential, Your Happiness Was Hacked, The Driver in the Driverless Car, Innovating Women, and The Immigrant Exodus.Greg and Vivek discuss Vivek's journey from tech entrepreneur to academic and prolific author. They discuss Vivek's different books focusing on innovation, legacy companies, and the impact of technology on society. Vivek highlights the failures of traditional innovation methods, the cultural transformations necessary for company revitalization, and the broader societal impacts of technology addiction. Additionally, Vivek shares his personal strategies for managing tech distractions in his own life and emphasizes the necessity of face-to-face interactions for true innovation in business.*unSILOed Podcast is produced by University FM.***This episode was recorded in 2021.**Show Links:Recommended Resources:MicrosoftSatya NadellaClayton ChristensenFord Greenfield LabsDoug McMillonFrederick TermanSilicon ValleyMichael PorterMark ZuckerbergMitch KaporSteve CaseGuest Profile:Wadhwa.comLinkedIn ProfileWikipedia ProfileFragomen ProfileSocial Profile on XHis Work:Amazon Author PageFrom Incremental to Exponential: How Large Companies Can See the Future and Rethink InnovationThe Driver in the Driverless Car: How Your Technology Choices Create the FutureYour Happiness Was Hacked: Why Tech Is Winning the Battle to Control Your Brain—and How to Fight BackThe Immigrant Exodus: Why America Is Losing the Global Race to Capture Entrepreneurial TalentInnovating Women: The Changing Face of TechnologyEpisode Quotes:The reason silicon valley can't be replicated14:19: Silicon Valley can't be replicated because you need much more than a few people. It's all about culture, the fact that we interact with each other. I mean, you go to parties over here. I mean, I remember coming to Silicon Valley 12 years ago and bumping into Mark Zuckerberg. I said, "Oh my God, Mark Zuckerberg is here." And then you bump into Mitch Kapor, you know, all of these people, and you just go up to them, and they talk to you like normal people. So it's informal; you go to any coffee shop over here, and you ask someone, "You know, what are you doing?" First of all, they'll start telling you about all the things that they failed in. They'll show off about their failure, and then they'll openly tell you what they're doing. Try doing that anywhere else in the world.On how are the people being addicted to technologies 47:41:The fact is that all of us are addicted. We're checking email. We wake up in the morning, and we check email. We go to bed late at night; we're checking email. We're traveling home from work; we're checking email. Right? We're now exchanging texts, you know, 24/7. When we have any free time, we'll start watching some TikTok videos. I mean, the kids, from the time they're like six months old now, seem to be on their iPads and so on. And the result is that teen suicide rates are high. We're not aware. All the studies about happiness show that we are less happy than we ever were. So everything good that should have happened hasn't happened. Instead, we've become addicted, and it's become a big problem for us. Disruption can come from anywhere08:38: You have to be aware that disruption would come from everywhere, and you need to have all hands on deck. It's no longer R&D departments that specialize in developing some specific technology—it's everyone in your company, right? Marketing, customer support, sales, your engineers, of course, finance—everyone now has a role in disruption, helping you reinvent yourself.

Technology: your master, or your friend? Do you feel ruled by your smartphone and enslaved by your email or social-network activities? Digital technology is making us miserable, say bestselling authors and former tech executives Vivek Wadhwa and Alex Salkever. We've become a tribe of tech addicts—and it's not entirely our fault. Michael talks with Vivek Wadhwa, co-author of "Your Happiness Was Hacked: Why Tech Is Winning the Battle to Control Your Brain--and How to Fight Back." In the book, learn how we can reclaim our lives without dismissing technology by how to avoid getting hooked on tech and how to define and control the roles that tech is playing and could play in our lives. Original air date 25 June 2018. The book was published on 26 June 2018.

Vivek Wadhwa is an academic, entrepreneur, and author of five best-selling books including: From Incremental to Exponential; Your Happiness Was Hacked: Why Tech is Winning the Battle to Control Your Brain--- as well as The Driver in the Driverless Car: How Our Technology Choices Will Create the Future. The post Where You Go to School Doesn't Matter With Vivek Wadhwa, author [re-release] appeared first on Time4Coffee.

Dear listeners, this week we celebrate our 100th episode. We want to take this opportunity to thank you for your support and listenership, as we treat you to a compilation of some of our favorite insights over the past years. Below you'll find a highlights reel broken down into clips in four categories:CLASSIC STRATEGY: Featuring Rita, McGrath, Richard Rumelt, John Hagel, and Mike Tushman who each share with us timeless ideas around strategy.LEADERSHIP, CULTURE & WORKFORCE: Featuring Adam Bryant, Ajay Banga, Sally Susman, Johnny C. Taylor, Tiffani Bova, and Elizabeth Altman, who each share critical insights into leadership, our employees, and the quickly changing landscape of the workforce.VALUE CREATION: Featuring Felix Oberholzer-Gee, Thales Teixeira, Pete Fader, and Mohan Subramaniam, who each share alternative and modern views around value creation.INNOVATION, TECH & THE FUTURE: Featuring Alex Osterwalder, Rob Wolcott, Vivek Wadhwa, and Faith Popcorn who each share with us insightful ideas around innovation, upcoming trends in tech and society, and the future of business._________________________________________________________________________________________Episode Timeline:00:34—Special Introduction to 100th Episode from KaihanCLASSIC STRATEGY2:57—Highlight from Rita McGrath: Strategic Planning Amidst Uncertainty5:24—Highlight from Richard Rumelt: Finding the Crux of Your Strategy7:01—Highlight from John Hagel: Why You Should "Zoom Out, Zoom In," and Scale From the Edge9:01—Highlight from Mike Tushman: Why Ambidextrous Organizations Outperform OthersLEADERSHIP/CULTURE/WORKFORCE10:52—Highlight from Adam Bryant: Good vs. GREAT CEOs—500 Interviews Reveal What Makes the Difference12:58—Highlight from Ajay Banga: Insights from a Former CEO with Ajay Banga of MasterCard15:11—Highlight from Sally Susman: Insights from Pfizer's Chief Corporate Affairs Officer in Crafting Public Discourse17:27—Highlight from Johnny C. Taylor: Trends You Need to Know About the Workforce19:27—Highlight from Tiffani Bova: Elevating Your EX to Improve Your CX21:01—Highlight from Elizabeth Altman: Rethinking the Definition of a Workforce in the Modern EraVALUE CREATION23:24—Highlight from Felix Oberholzer-Gee: Applying a Value-Based Strategy to Drive Your Business26:11—Highlight from Thales Teixeira: Decoupling the Customer Value Chain for Competitive Advantage28:36—Highlight from Pete Fader: Becoming a Customer-Centric Business30:49—Highlight from Mohan Subramaniam: The Future of Competitive Strategy and the Evolving Role of Data, Customers and Digital EcosystemsINNOVATION, TECH & THE FUTURE33:46—Highlight from Alexander Osterwalder: How Investing in Culture Ecosystems Leads to Innovation35:57—Highlight from Rob Wolcott: The Power of Proximity in your Strategy38:31—Highlight from Vivek Wadhwa: Harnessing Tech for an Innovative Future40:24—Highlight from Faith Popcorn: Predictions to Know From a Leading Futurist42:34—Closing and Thank you

Dear listeners, this week we celebrate our 100th episode. We want to take this opportunity to thank you for your support and listenership, as we treat you to a compilation of some of our favorite insights over the past years. Below you'll find a highlights reel broken down into clips in four categories:CLASSIC STRATEGY: Featuring Rita, McGrath, Richard Rumelt, John Hagel, and Mike Tushman who each share with us timeless ideas around strategy.LEADERSHIP, CULTURE & WORKFORCE: Featuring Adam Bryant, Ajay Banga, Sally Susman, Johnny C. Taylor, Tiffani Bova, and Elizabeth Altman, who each share critical insights into leadership, our employees, and the quickly changing landscape of the workforce.VALUE CREATION: Featuring Felix Oberholzer-Gee, Thales Teixeira, Pete Fader, and Mohan Subramaniam, who each share alternative and modern views around value creation.INNOVATION, TECH & THE FUTURE: Featuring Alex Osterwalder, Rob Wolcott, Vivek Wadhwa, and Faith Popcorn who each share with us insightful ideas around innovation, upcoming trends in tech and society, and the future of business._________________________________________________________________________________________Episode Timeline:00:34—Special Introduction to 100th Episode from KaihanCLASSIC STRATEGY2:57—Highlight from Rita McGrath: Strategic Planning Amidst Uncertainty5:24—Highlight from Richard Rumelt: Finding the Crux of Your Strategy7:01—Highlight from John Hagel: Why You Should "Zoom Out, Zoom In," and Scale From the Edge9:01—Highlight from Mike Tushman: Why Ambidextrous Organizations Outperform OthersLEADERSHIP/CULTURE/WORKFORCE10:52—Highlight from Adam Bryant: Good vs. GREAT CEOs—500 Interviews Reveal What Makes the Difference12:58—Highlight from Ajay Banga: Insights from a Former CEO with Ajay Banga of MasterCard15:11—Highlight from Sally Susman: Insights from Pfizer's Chief Corporate Affairs Officer in Crafting Public Discourse17:27—Highlight from Johnny C. Taylor: Trends You Need to Know About the Workforce19:27—Highlight from Tiffani Bova: Elevating Your EX to Improve Your CX21:01—Highlight from Elizabeth Altman: Rethinking the Definition of a Workforce in the Modern EraVALUE CREATION23:24—Highlight from Felix Oberholzer-Gee: Applying a Value-Based Strategy to Drive Your Business26:11—Highlight from Thales Teixeira: Decoupling the Customer Value Chain for Competitive Advantage28:36—Highlight from Pete Fader: Becoming a Customer-Centric Business30:49—Highlight from Mohan Subramaniam: The Future of Competitive Strategy and the Evolving Role of Data, Customers and Digital EcosystemsINNOVATION, TECH & THE FUTURE33:46—Highlight from Alexander Osterwalder: How Investing in Culture Ecosystems Leads to Innovation35:57—Highlight from Rob Wolcott: The Power of Proximity in your Strategy38:31—Highlight from Vivek Wadhwa: Harnessing Tech for an Innovative Future40:24—Highlight from Faith Popcorn: Predictions to Know From a Leading Futurist42:34—Closing and Thank you

Hosted by Andrew Keen, Keen On features conversations with some of the world's leading thinkers and writers about the economic, political, and technological issues being discussed in the news, right now. In this episode, Andrew is joined by Vivek Wadhwa, authors of From Incremental to Exponential: How Large Companies Can See the Future and Rethink Innovation. Vivek Wadhwa is director of research at the Center for Entrepreneurship and Research Commercialization and executive in residence at the Pratt School of Engineering, Duke University; vice president of innovation and strategy at Singularity University; fellow at the Arthur & Toni Rembe Rock Center for Corporate Governance, Stanford University; and distinguished visiting scholar, Halle Institute of Global Learning, Emory University. He is a regular columnist for the Washington Post, Bloomberg BusinessWeek, and Forbes.com. In February 2012, the US government awarded him distinguished recognition as an “Outstanding American by Choice” for his “commitment to this country and to the common civic values that unite us as Americans.” Learn more about your ad choices. Visit megaphone.fm/adchoices

As India's original startup turned 40, its founder and face NR Narayana Murthy said he wants to reverse its biggest unwritten rule of not allowing family into the management.  How will this impact the company's succession plan? Are the founders' children willing and worthy? Does it really need a reversal of its brilliant run? Host Anirban Chowdhury talks to Peter Bendor-Samuel, founder, Everest Group, Vivek Wadhwa, tech entrepreneur and academic, professor at Carnegie Mellon's School of Engineering and Archana Rai, editor, South, ET.Credit: CNBC-TV18, NDTVYou can follow our host Anirban on his social media:Twitter - https://twitter.com/AnirbanETLinkedin - https://www.linkedin.com/in/anirban-chowdhury-b5067219/ Catch the latest episode of ‘The Morning Brief' on ET Play, The Economic Times Online, Spotify, Apple Podcasts, JioSaavn, Amazon Music and Google Podcasts.See omnystudio.com/listener for privacy information.

The richest man alive has bought Twitter and is bending it to his will. But Elon Musk is not the only billionaire who has a huge impact on society - they all do.That's why people are fascinated by the world's top business leaders.But is media hype to blame as well? Former CEO of the cryptocurrency exchange FTX, Sam Bankman-Fried, was also a media darling for years before the collapse of his company.And what traits mark the difference between a successful CEO and a disastrous leader?Host Steve Clemons talks to management gurus Jeffrey Sonnenfeld, professor of management at Yale University, and Vivek Wadhwa, a technology entrepreneur.

Vivek Wadhwa is a Distinguished Fellow at Harvard Law School (ret), Distinguished Fellow & Adjunct Professor at Carnegie Mellon. HE is the author of bestsellers books - Your Happiness Was Hacked, Driver in the Driverless Car, Innovating Women: The Changing Face of Technology, and Immigrant Exodus. --- Support this podcast: https://anchor.fm/theindustryshow/support

Hosted by Andrew Keen, Keen On features conversations with some of the world's leading thinkers and writers about the economic, political, and technological issues being discussed in the news, right now. In this episode, Andrew is joined by Vivek Wadhwa, author of Driver in the Driverless Car: How Our Technology Choices Will Create the Future. Vivek Wadhwa is an academic, entrepreneur, and author of five best-selling books: From Incremental to Exponential; Your Happiness Was Hacked; The Driver in the Driverless Car; Innovating Women; and The Immigrant Exodus. He has been a globally syndicated columnist for The Washington Post and has held appointments as Distinguished Fellow at Harvard Law School's Labor and Worklife Program, Carnegie Mellon University, and Emory University; adjunct professor at Carnegie Mellon and Duke University; fellow at Stanford Law School and UC Berkeley; and head of faculty at Singularity University. He was also named one of the world's “Top 100 Global Thinkers” by Foreign Policy magazine in that year; in June 2013, he was on TIME magazine's list of “Tech 40”, one of forty of the most influential minds in tech; and in September 2015, he was second on a list of “ten men worth emulating” in The Financial Times. In 2018, he was awarded Silicon Valley Forum's Visionary Award, a list of luminaries “who have made Silicon Valley synonymous with creativity and life-changing advancements in technology.” Learn more about your ad choices. Visit megaphone.fm/adchoices

In this episode, Tim Kane chats to American technology entrepreneur and academic, Vivek Wadhwa. After living in the US as a child, Vivek says he was determined to move back to what he calls “the greatest country in the world”. Vivek has founded numerous successful tech companies, is the author of several books and has lectured at some of the top Universities in America. Now, he says he's on a mission to cure cancer. This episode isn't short of controversy as Vivek shares his thoughts on how America could do better at keeping skilled immigrants. --- Send in a voice message: https://anchor.fm/why-america/message

I read an article written by an author named Vivek Wadhwa.  He's a research analyst from Stanford University who wrote on the benefits of aging.  Agism.  He spoke of how the trend in the Silicon Valley is “to fund [hire] entrepreneurs who are hardly...

In this episode, I sit down with Vivek Wadhwa to talk about his pivot from tech entrepreneur and big tech enthusiast, to critic and activist. We talk about his path to tech and then to his activism in education, his research into tech innovation, and his research into the importance of global diversity when considering questions of how we imagine, innovate, and build. Vivek Wadhwa is a Distinguished Fellow at Harvard Law School's Labor and Worklife Program. He is the author of five best-selling books: From Incremental to Exponential; Your Happiness Was Hacked; The Driver in the Driverless Car; Innovating Women; and The Immigrant Exodus. He has been a globally syndicated columnist for The Washington Post and held appointments at Carnegie Mellon University, Duke University, Stanford Law School, UC Berkeley, Emory University, and Singularity University. In 2012, the U.S. Government awarded Wadhwa distinguished recognition as an “Outstanding American by Choice” for his “commitment to this country and to the common civic values that unite us as Americans.” He was also named one of the world's “Top 100 Global Thinkers” by Foreign Policy magazine in that year; in June 2013, he was on TIME magazine's list of “Tech 40”, one of forty of the most influential minds in tech; and in September 2015, he was second on a list of “ten men worth emulating” in The Financial Times. In 2018, he was awarded Silicon Valley Forum's Visionary Award, a list of luminaries “who have made Silicon Valley synonymous with creativity and life-changing advancements in technology.”   Wadhwa is an advisor to several governments; mentors entrepreneurs; and writes for top publications across the globe. He has also researched Silicon Valley's diversity, or the lack of it.  He documented that women entrepreneurs have the same backgrounds and motivations as men do, but are rare in the ranks of technology CEOs and CTOs. He is the founding president of the Carolinas chapter of The IndUS Entrepreneurs (TIE), a non-profit global network intended to foster entrepreneurship.  He has been featured in thousands of articles in publications worldwide, including the Wall Street Journal, The Economist, Forbes magazine, The Washington Post, The New York Times, U.S. News and World Report, and Science Magazine, and has made many appearances on U.S. and international TV stations, including CBS 60 Minutes, PBS, CNN, ABC, NBC, CNBC, and the BBC. This episode was produced by Mereck Palazzo & Matt Perry. Art by Desi Aleman.

From deliveries to despatches, the business of drones is set to boom as regulators relax laws. But while companies and consumers benefit, for some countries it is also becoming a security hazard and a tool for terror attacks. Academic and tech entrepreneur Vivek Wadhwa and startup Skylark Drones' CEO Mughilan Thiru Ramasamy tell us what the drones of the future will look like, and what we need to do to keep our skies safe.

Vivek Wadhwa is author of The Immigrant Exodus:—which was named by The Economist as a Book of the Year of 2012, From Incremental to Exponential: How Large Companies Can See the Future and Rethink Innovation, Your Happiness Was Hacked , The Driver in the Driverless Car & Innovating Women: The Changing Face of Technology—which documents the struggles and triumphs of women. He was named by Foreign Policy Magazine as Top 100 Global Thinker in 2012. In 2013, TIME Magazine listed him as one of The 40 Most Influential Minds in Tech. Earlier Wadhwa oversaw research at Singularity University, which educates a select group of leaders about the exponentially advancing technologies that are soon going to change our world. These advances—in fields such as robotics, A.I., computing, synthetic biology, 3D printing, medicine, and nanomaterials—are making it possible for small teams to do what was once possible only for governments and large corporations to do: solve the grand challenges in education, water, food, shelter, health, and security. In his roles at Stanford and Duke, Wadhwa lectures in class on subjects such as entrepreneurship and public policy, helps prepare students for the real world, and leads groundbreaking research projects. He is an advisor to several governments; mentors entrepreneurs; and is a regular columnist for The Washington Post, Wall Street Journal Accelerators, LinkedIn Influencers blog, Forbes, and the American Society of Engineering Education's Prism magazine. Prior to joining academia in 2005, Wadhwa founded two software companies. https://wadhwa.com/ https://twitter.com/wadhwa https://www.linkedin.com/in/vwadhwa https://singularityhub.com/author/vwadhwa/

Episode two of the North Star explores the future of innovation from a variety of perspectives. Guest and renowned scholar, researcher, and entrepreneur Vivek Wadhwa joins host William Ulrich to share his insights on a variety of topics linked to innovation, technology advancements and the future. The episode will explore how organizations, particularly large legacy businesses, can innovate in a world of intense competition that can emerge from all quarters, including new startup companies. Vivek will discuss how large, legacy companies can leverage the benefits of incumbency to create new markets, supercharge growth and remake their organization by applying a startup mindset. The episode will also explore the implications of artificial intelligence (AI) and related technology advancements and discuss how our technology choices will determine if the future turns out to be closer to an ideal utopia or a terrifying dystopia. Will technology advancements make our lives happier, healthier, and safer, or will they create a frightening future of a jobless economy, complete loss of privacy, and worsening economic equality. The episode will also explore what innovation and advancing technologies spell for workers in global job markets, particularly as more and more economies turn to green energy and related pursuits. Finally, William and Vivek will discuss where he sees things headed and share advice for workers, entrepreneurs, and organizations in general.

Public talk with Vivek Wadhwa about technology and our future

In this episode Kaihan welcomes Vivek Wadhwa, who talks with him about exponential technologies, what it takes for a large legacy company to act like a nimble entrepreneurial one, and why at this moment, over the next decade or so, we have one of the biggest opportunities humanity has faced in our history. Vivek is a Distinguished Fellow at Harvard Law School's Labor and Worklife Program. He's based in Silicon Valley and researches, speaks, and writes about advancing technologies such as robotics, artificial intelligence, synthetic biology and nanomaterials. He's the author of five bestselling books and was named one of the world's “Top 100 Global Thinkers” by Foreign Policy magazine, was on TIME magazine's list of “Tech 40," one of forty of the most influential minds in tech.In this discussion, Vivek helps us understand how we can create a “start trek” future in which we have almost unlimited free clean energy, an abundance of food for the planet, cure almost every disease, and educate the world. We can have that if we make the right choices about how and where technology is used. But if we don't play our cards right, we could be headed to a dark future, the “mad max” future. He leaves us finally with some concrete ideas of what you can do right now, as an innovator, as a strategist, to move us toward that “star trek” future. __________________________________________________________________________________________"The problem is that every technology can be used for good and it can be used for evil. The first technology was fire. Fire could use to keep us warm, or it could be used to burn down houses. That's the way it's always been.Use technology for good...You can use technologies for uplifting communities. You can help the poor. You can do a lot of good for the world. Think big, start, small solve problems."-Vivek Wadhwa__________________________________________________________________________________________Episode Timeline:00:00—Introducing Vivek Wadhwa + The topic of today's episode2:30—If you really knew me, you know that...3:04—What is your definition of strategy?4:08—How can a linear large company act like an agile exponential one?6:06—Could you describe exponential technologies and point us to ones that people aren't paying as much attention to that we should be?8:09—Can you tell us about the implications of devices not only being smarter, but also communicating better?9:33—What are you predictions for fundamentals, like energy, food, health and education?12:00—What is the challenge for us to be able to create or plan for this exponential Star Trek future or maybe the dark future? 14:21—We can't rely on the individual to say "This technology should be used for good." How do we unravel that?16:20—Is there an action, a framework, a tool, a step that you would recommend that someone take?__________________________________________________________________________________________Resources Mentioned:Clayton M. Christensen: The Innovator's Dilemma: When New Technologies Cause Great Firms to FailVivek Wadhwa: From Incremental to Exponential: How Large Companies Can See the Future and Rethink Innovation

In this episode Kaihan welcomes Vivek Wadhwa, who talks with him about exponential technologies, what it takes for a large legacy company to act like a nimble entrepreneurial one, and why at this moment, over the next decade or so, we have one of the biggest opportunities humanity has faced in our history. Vivek is a Distinguished Fellow at Harvard Law School's Labor and Worklife Program. He's based in Silicon Valley and researches, speaks, and writes about advancing technologies such as robotics, artificial intelligence, synthetic biology and nanomaterials. He's the author of five bestselling books and was named one of the world's “Top 100 Global Thinkers” by Foreign Policy magazine, was on TIME magazine's list of “Tech 40," one of forty of the most influential minds in tech.In this discussion, Vivek helps us understand how we can create a “start trek” future in which we have almost unlimited free clean energy, an abundance of food for the planet, cure almost every disease, and educate the world. We can have that if we make the right choices about how and where technology is used. But if we don't play our cards right, we could be headed to a dark future, the “mad max” future. He leaves us finally with some concrete ideas of what you can do right now, as an innovator, as a strategist, to move us toward that “star trek” future. __________________________________________________________________________________________"The problem is that every technology can be used for good and it can be used for evil. The first technology was fire. Fire could use to keep us warm, or it could be used to burn down houses. That's the way it's always been.Use technology for good...You can use technologies for uplifting communities. You can help the poor. You can do a lot of good for the world. Think big, start, small solve problems."-Vivek Wadhwa__________________________________________________________________________________________Episode Timeline:00:00—Introducing Vivek Wadhwa + The topic of today's episode2:30—If you really knew me, you know that...3:04—What is your definition of strategy?4:08—How can a linear large company act like an agile exponential one?6:06—Could you describe exponential technologies and point us to ones that people aren't paying as much attention to that we should be?8:09—Can you tell us about the implications of devices not only being smarter, but also communicating better?9:33—What are you predictions for fundamentals, like energy, food, health and education?12:00—What is the challenge for us to be able to create or plan for this exponential Star Trek future or maybe the dark future? 14:21—We can't rely on the individual to say "This technology should be used for good." How do we unravel that?16:20—Is there an action, a framework, a tool, a step that you would recommend that someone take?__________________________________________________________________________________________Resources Mentioned:Clayton M. Christensen: The Innovator's Dilemma: When New Technologies Cause Great Firms to FailVivek Wadhwa: From Incremental to Exponential: How Large Companies Can See the Future and Rethink Innovation

I met Vivek several years ago in Houston, TX and have been in contact every now and then. With his knowledge and expertise in technology shaping the future and his engagements with Harvard, Stanford, Carnegie-Mellon, Duke, I thought it was great to hear Vivek's opinions on where we are heading.Here we are, still enduring the pandemic; we are able to create new deadly viruses and look at how quickly we, humanity, have been able to develop solution. This shows on how quick technology development is taking place. For just a few years ago this would not have been possible.The next 8-9 years will be more amazing than the previous 80-90 years. This decade will bring more progress than the last 100 years.What we see happening now is our adaption of technology with electric vehicles, autonomous drive, clean energy and cleaning up our planet. We will see more drone technology and 3D printed housing and food. Living will get cheaper. This transition will create a big mass of new jobs, however the automation and robots will then take over the jobs. Some of Wadhwa's views on technology you can read about in his book “the Driver in the Driverless Car”Technology adoption is key, find ways to embrace the new and share the knowledge. We need to work jointly for the benefit of humanity. Sharing equally is key. (NOTE: listen to the episode with Ernesto Sirolli, he has the same message).The future needs to give us freedom of choice, not just rigid control.AI, what is it? Are we overhyping it or are we able to utilize it properly? The bias in pattern recognition is happening many places, which can be scary and dangerous, so we need to be very careful in how it is put in use.And is the innovation and venture capital going to stay/grow in Silicon Valley, is the magic still around? We ended up discussing the quality of life in the Silicon Valley vs. other regions. As a matter of fact this is the cliffhanger - as a follow-up we are going to have a second round of discussion in a couple of months on how innovative and good life is in Silicon Valley but also the Nordic region. And we need to discuss his most recent book also - “From Incremental to Exponential”. Until then, I hope you enjoy this episode! This is a public episode. If you would like to discuss this with other subscribers or get access to bonus episodes, visit mikatienhaara.substack.com

In this episode Vivek Wadhwa author, academic, entrepreneur explores the ideas in his book 'From Incremental to Exponential: How Large Companies Can See the Future and Rethink Innovation' in a conversation with Dr. Srivatsa Krishna, IAS and Secretary CEO of Coffee Board of India.  Ray Kurzweil of Singularity University has predicted that for the first time in human history, we are entering the “Exponential Era”. We are going to experience 20,000 years of technological change in the next 100 years- from the birth of agriculture to the birth of the Internet, twice, in the next century. We are living in the times when flying taxis, autonomous vehicles, robots as personal valets, reusable rockets are all happening in front of our eyes, most of them ready for prime time. For the first time there is not only Moore’s Law like acceleration in several technologies but also convergence among them. How will these impact governments? Can they remain immune to change or will this lead to more innovating governments? How must governments in India and elsewhere leverage these technologies to serve better? How do we move from 'Incremental to Exponential' in governance? The original live event was in collaboration with the IAS Officers Association. 

The COVID-19 pandemic has taught all of us about the power of exponential change. In this interview, Paul Laudicina talks to futurist Vivek Wadhwa about where exponential change might take us in the near future.  The explosive and disruptive changes in virtual reality, clean energy, genetic engineering, and AI, among other new technologies,  will propel us into a new reality. Will we be able to come together as a global society to harness the power of these massive changes? And what will the next decade look like? A World Transformed: Reimagining the Future is produced by the Global Business Policy Council at Kearney, a think tank deciphering today's biggest changes and their effects on global business. Learn more at kearney.com/gbpc.

Vivek Wadhwa’s advice to parents who ask him what their kids should study in college to be guaranteed a job when they graduate?  Let them study what makes them happy.  What are they interested in studying, he asks parents?  This episode is chockablock with sage advice and revealing insights into one of our world’s deepest thinkers about how to become a truly fulfilled, successful and happy student/professional -- at college and beyond. Vivek is a Distinguished Fellow at Harvard Law School and Carnegie Mellon University’s College of Engineering at Silicon Valley. The post Why Your College Major & Where You Go to School Don’t Matter With Vivek Wadhwa [re-release] appeared first on Time4Coffee.

In this episode of the Effective Family Office Podcast, host Angelo Robles speaks with professor and futurist, Vivek Wadhwa, who shares his views on China, Tik Tok, and Microsoft.

Welcome to East West Hurricane! 🌪We update you on the most essential news from Asia in tech, media, and business—the things you need to know that you probably haven’t heard in Western media.Follow us on Twitter and Instagram! ⚡️The Big Moment for Indian Tech 📱India’s expulsion of 59 Chinese apps earlier this week is a watershed moment in Indian tech, depending on how long the ban lasts and what happens next. This op-ed by Vivek Wadhwa in the Hindustan Times describes some of the potential tech opportunities this gives to India, framing this positively. At the same time, other opinion pieces like this one from Apar Gupta in The Hindu criticise the ban. The closest thing to this ban is how China banned Western tech companies like Facebook and Instagram. You could argue that China’s own consumer tech companies (WeChat, Weibo, QQ, etc.) were able to thrive because they didn’t have as much competition from Western tech alternatives. Could India now execute on a similar strategy, creating natively Indian versions of these banned Chinese mobile apps? Another angle to this is looking at what else is currently affecting India’s labour market—US Visas. Donald Trump recently announced that several US work visas will have their approval processes suspended until the end of the year, including the H-1B visas most commonly used by the US tech industry. Putting aside the cultural, social, and psychological consequences of this decision on the US’s ability to attract foreign talent, it has a significant impact on India specifically. India accounts for 70% of the 85,000 total H-1B visas issued annually, so thousands of Indian employees and American tech companies have had their 2020 plans disrupted.Now suddenly India’s tech landscape has less competition, because of banned Chinese apps. At the same time, India’s highly skilled tech workers who would have moved to the US for job opportunities suddenly cannot, because of restrictions in US work visa policy. What could this mean for India?AngelList launches EquityList for India 💸AngelList is one of Silicon Valley’s best known companies, a marketplace/job listings site that connects startup founders with angel investors. They have just announced the launch of a new product specifically for the Indian market called EquityList. EquityList is a tool that allows founders to manage their equity stakes, issue equity to employees, and perform a host of other equity-related functions. This takes out many of the operational and fiscal burdens that comes with distribution and tracking of equity in a startup.This is just the latest in a series of new investments made by AngelList specifically targeting India. They also launched an Indian micro-VC fund called iSeed in May. AngelList India itself was launched in 2018. Things are heating up in the Indian tech market—there are surely many more announcements to come.Exporting Korean Culture 🇰🇷This week, the Korean Academic Society for Public Relations hosted an event in Seoul discussing how to promote Korean Culture in a post-Covid world. The event was sponsored by the Korean Culture and Information Service, and supported by several government officials. The attendees discussed how to frame the positive messaging of Korea given the country’s relative success in stopping Covid and how to choose the right medium to deliver these messages.Promoting your country’s ‘brand’ has always been a thing, whether done by national tourism boards or other government agencies. Putting aside Covid, Korea’s ‘brand’ has been rising rapidly over the last five years and seeing these types of events makes me realise that the Korean government takes this seriously. I’m currently in New Zealand, and there have been similar discussions raised by certain government officials on how to capitalise on New Zealand’s ‘brand’ in a post-Covid world. Although my opinion is that New Zealand takes this less seriously than Korea, I’m bullish on the commercial and social opportunities afforded to the Asia-Pacific countries who have dealt with Covid effectively. This is a public episode. If you would like to discuss this with other subscribers or get access to bonus episodes, visit eastwesthurricane.substack.com

Vivek Wadhwa is a Distinguished Fellow at Carnegie Mellon University's College of Engineering and a director of research at Duke University's Pratt School of Engineering. He is a globally syndicated columnist for the Washington Post; author of The Immigrant Exodus, which the Economist named a Book of the Year of 2012; and coauthor of Innovating Women, which documents the struggles and triumphs of women in technology. Wadhwa has held appointments at Stanford Law School, Harvard Law School, UC Berkeley, and Emory University and is an adjunct faculty member at Singularity University. Learn more about your ad choices. Visit megaphone.fm/adchoices

It may sound simple, but the first step to implementing AI in your enterprise is to know what it does. In this episode, Vivek Wadhwa, entrepreneur and Adjunct Professor at Carnegie Mellon, unlocks the black box of AI, including what is needed to build a proper AI foundation. Hint: it’s more than just data. Wadhwa goes on to bust myths about machine learning and the overinflated claims some vendors make regarding the utilization of ML and AI. By taking an academic, honest—sometimes brutally so—and deep look at corporate AI, Wadhwa helps enterprises avoid the pitfalls of AI’s oversell in the corporate market.

It may sound simple, but the first step to implementing AI in your enterprise is to know what it does. In this episode, Vivek Wadhwa, entrepreneur and Adjunct Professor at Carnegie Mellon, unlocks the black box of AI, including what is needed to build a proper AI foundation. Hint: it's more than just data. Wadhwa goes on to bust myths about machine learning and the overinflated claims some vendors make regarding the utilization of ML and AI. By taking an academic, honest—sometimes brutally so—and deep look at corporate AI, Wadhwa helps enterprises avoid the pitfalls of AI's oversell in the corporate market.

It may sound simple, but the first step to implementing AI in your enterprise is to know what it does. In this episode, Vivek Wadhwa, entrepreneur and Adjunct Professor at Carnegie Mellon, unlocks the black box of AI, including what is needed to build a proper AI foundation. Hint: it’s more than just data. Wadhwa goes on to bust myths about machine learning and the overinflated claims some vendors make regarding the utilization of ML and AI. By taking an academic, honest—sometimes brutally so—and deep look at corporate AI, Wadhwa helps enterprises avoid the pitfalls of AI’s oversell in the corporate market.

How will technology impact the future of work — and how is it impacting our happiness today? In today’s episode, Curt interviews writer, futurist and technology expert Alex Salkever. He is the co-author, with Dr. Vivek Wadhwa, of “The Driver in the Driverless Car: How Our Technology Choices Can Change the Future" and "Your Happiness Was Hacked: Why Tech Is Winning The Battle To Control Your Brain - And How To Fight Back."

Vivek Wadhwa is a Silicon Valley futurist, renaissance man, & raconteur. He joins us for an provocative & rollicking discussion of artificial intelligence in healthcare, the current and future state of health data privacy, & how his personal journey spurs his work. He brings a sense of urgency and enthusiasm to this topic, and shares why he feels that way. Caution: hot takes ahead! Key Learnings 1. Laying out the underpinnings of a revolution in the next 5-10 years 2. The idea of having sensors on our bodies measuring and tracking our biometircs 3. Miniaturization and nano-bots providing targeted therapy 4. Genomics and the impact of massively decreased costs 5. Connecting these three components with artificial intelligence to build a data-driven revolution in healthcare 6. Are tech companies putting patients or plunder at the center? 7. Vivek gives the most succinct assessment of privacy concerns and health data you'll ever get. 8. How we can get a "Democratization of diagnostics" 9. Helping to define AI as a tool for pattern recognition and data analytics 10. What the role of the physician will be in this brave new world and how do people begin to learn about this 11. How the illness of a loved one has spurred Vivek's interest in this work the impact of having yourself or a loved one be "deep water sick" Links Vivek Wadhwa's homepage: www.wadhwa.com How health apps feed your data to Facebook #AI, #artificialintelligence, #data, #dataprivacy, #facebook, #nanotechnology, #healthcare, #revolution  

Are we catching up to make Star Wars a reality? Yes we are, according to Vivek Wadhwa, Distinguished Fellow and adjunct professor at Carnegie Mellon University's College of Engineering. Artificial Intelligence (AI) will change the world forever; and as history teaches us, we can never go back. Join us this week as we discuss the meaning of work when robots can do everything, and we are quickly realizing what seemed like fiction in Star Wars. What will happen to the driver in driverless cars? Vivek Wadhwa argues (and we agree) that AI is changing the dynamics of life and that we are on the verge of solving the “grand challenges of humanity”. It is an exciting time for those who embrace it and a very bumpy one for those who have their heads in the sand. Join us for a lively discussion with Vivek Wadhwa, author and named one of the top 100 global thinkers and top 40 most influential minds in tech by Time Magazine. Vivek Wadhwa is a globally syndicated columnist for The Washington Post and author of The Driver in the Driverless Car: How Our Technology Choices Will Create the Future;  The Immigrant Exodus: Why America Is Losing the Global Race to Capture Entrepreneurial Talent, which was named by The Economist as a Book of the Year of 2012; and of Innovating Women: The Changing Face of Technology, which documents the struggles and triumphs of women. Wadhwa has held appointments at Duke University, Stanford Law School, Harvard Law School, Emory University, and Singularity University.

Vivek Wadhwa researches exponentially advancing technologies that will soon change our world.  These advances--in fields such as robotics, artificial intelligence, computing, synthetic biology, 3D printing, medicine and nanomaterials--are making it possible for small teams to do what was once possible only for governments and large corporations to do: solve the grand challenges in education, water, food, shelter, health and security.  Vivek Wadhwa is a Silicon Valley entrepreneur, engineer, computer software programmer, author and professor. Professor Wadhwa is a Distinguished Fellow at Harvard Law School and Carnegie Mellon University’s College of Engineering at Silicon Valley. The post 28: How Anyone, Anywhere Can Build World-Changing Technology w/ Vivek Wadhwa [Espresso Shots] appeared first on Time4Coffee.

Vivek Wadhwa, a technology and innovation author and expert, academic and futurist, joins us to discuss the technologies that will shape the laundry of the future and how to prepare for those potential disruptions so that your business is primed for success. Wadhwa also will share his insights with TRSA members at the 105th Annual Conference and Exchange.

Dr. Nick Delgado and Dr. Vivek Wadhwa talk about how AIC Chile is building a machine that can bring a 100% sanitized water. Technological innovations are bringing disruption to all industries at a rapid pace. Robotics, Nanotech and Software are making the world a better place.

If you’ve never heard Vivek Wadhwa speak, or read his articles and books, and even if you have, this is a T4C episode you won’t soon forget!  Professor Wadhwa’s advice to parents who ask him what their kids should study in college to be guaranteed a job when they graduate?  Let them study what makes them happy. The post 05: Why Your College Major & Where You Go to School Don’t Matter w/ Vivek Wadhwa appeared first on Time4Coffee.

Alex Salkever, Technology Expert and former Technology Editor at BusinessWeek, and Vivek Wadhwa, Distinguished Fellow at Harvard Law School’s Labor and Worklife Program and Professor at Carnegie Mellon University's College of Engineering, join host Rob Coneybeer to discuss their new book "Your Happiness Was Hacked: Why Tech Is Winning The Battle To Control Your Brain - And How To Fight Back" on Launch Pad. See acast.com/privacy for privacy and opt-out information.

“Parents have to get smarter than their children” In conversation with the Association's Jennifer Gardner, Professor Vivek Wadhwa outlines how today's changes in technology are fundamentally different compared to just 15 years ago. He shares some practical tips that help us limit technology's unintended impacts on our lives while benefiting from the opportunities it offers. OUR GUEST: Professor Wadhwa is an academic, a researcher, a writer and a tech entrepreneur based in Silicon Valley. He was on TIME magazine’s list of “Tech 40”, one of forty of the most influential minds in tech; and #2 of “ten men worth emulating” in The Financial Times.  He studies the exponentially advancing technologies that are soon going to change our world.  In his recent book "Your Happiness Hacked", he looks at how technology has altered our lives and not necessarily for the better.    == MORE ABOUT OUR PODCAST ==    DON'T MISS OUT. Get the latest show every week, automatically and free, at https://www.aicpa-cima.com/disruption.html. Share it easily with colleagues and friends by using the icons on the media player.  TAKE IT FURTHER. Find related CPD/CPE resources at https://www.aicpastore.com/GoBeyondDisruption and https://www.cgmastore.com/GoBeyonddisruption. STAY CONNECTED. Follow #GoBeyondDisruption, @AICPANews and @CIMA_News on social."   ©2018 Association of International Certified Professional Accountants (AICPA & CIMA). All rights reserved 

Our conversation with Vivek Wadhwa touched on a broad array of topics, following up on his two most recent books The Driver in the Driverless Car and Your Happiness Was Hacked: Why Tech Is Winning the Battle to Control Your Brain--and How to Fight Back. Our conversation covered the nature of exponential technologies as a foundation concept, along with the implications of AI/Machine Learning. He provided an optimistic outlook around self-driving cars and solar energy cost curves, with a bit of tempered enthusiasm around human gene-editing (CRISPr). The ways that technology is designed to hijack our attention, and how love, work and interpersonal relationships are being impacted are the focus of his new book, and he provides suggestions for us to better manage the disruption of technology in our lives.

I admit it. I confess. I’ve got a touch of what my guest today calls “progressophobia”. Ever since Charles Dickens got hold of me back in middle school, and William Blake after that, I’ve been a little suspicious of the Great Onward March of science and technology. Gene therapy, healthier crops, safer, more efficient forms of nuclear energy? Very nice, very nice. But what about eugenics, climate change, and Fukushima?  For every problem human ingenuity solves, doesn’t human nature create a new one, on a bigger scale? Dammit, Spock, can your cold, calculating reason fathom the mysteries of the human heart? But you know what? After devouring all 453 pages and 75 graphs of psychologist Steven Pinker’s new book ENLIGHTENMENT NOW, I admit defeat. The defeat of defeatism. This man has done the math. Since the 18th century things have been getting better in pretty much every dimension of human well-being. Health, safety, education, happiness, you name it… And we’ve done it with the most reliable tools we have: reason, science, and Enlightenment humanism. Surprise conversation-starter clips in this episode: Vivek Wadhwa on "your life in 2027" (note: we watched from 25:42 to 27:40)  Learn more about your ad choices. Visit megaphone.fm/adchoices

In this episode, Angelo speaks with Vivek Wadhwa, a Fellow at the Rock Center for Corporate Governance at Stanford University and also at the Pratt School of Engineering at Duke, where he’s a Director of Research. Angelo and Vivek discuss his predictions on a jobless future saving mankind, ethics of gene editing, and the disruption of industries.

Vivek Wadhwa is an academic specialising in exponentially advancing technologies

What are the social and ethical implications of new technologies such as widespread automation and gene editing? These innovations are no longer in the realm of science fiction, says entrepreneur and technology writer Vivek Wadhwa. They are coming closer and closer. We need to educate people about them and then come together and have probing and honest discussions on what is good and what is bad.

What are the social and ethical implications of new technologies such as widespread automation and gene editing? These innovations are no longer in the realm of science fiction, says entrepreneur and technology writer Vivek Wadhwa. They are coming closer and closer. We need to educate people about them and then come together and have probing and honest discussions on what is good and what is bad.

One of innovation's most widely followed futurists talks about why even the smallest startups now have the resources to create world-changing innovation -- and that is what they should do. Venture capitalists and big companies are dinosaurs who should either help or get out of the way. (Originally published 1/23/15)

In this episode, Angelo taps into the pulse of our current culture and looks to the future of our society with futurist, professor and author, Vivek Wadhwa. Based in the Silicon Valley, Vivek talks about advancing technologies that are soon going to change our world, and how a look to the future can help prepare single families for what’s to come.

(Bloomberg) -- Bloomberg Markets with Carol Massar and Cory Johnson. (Carol Solo)

(Bloomberg) -- Bloomberg Markets with Carol Massar and Cory Johnson. (Carol Solo) Learn more about your ad-choices at https://www.iheartpodcastnetwork.com

It's a story of ambition, innovation, management gone wrong: Uber. It's been a ride-hailing game changer, but also a cautionary tale, so this week on Fortt Knox Live, I brought together an expert panel to discuss the latest news and what it means for Silicon Valley. Mike Issac of the New York Times, Vivek Wadhwa of Carnegie Mellon, and my colleague Deirdre Bosa of CNBC joined me in San Francisco this week to break down the big changes coming for Uber's management, and what the rest of us can learn. Here's our conversation: Learn more about your ad choices. Visit megaphone.fm/adchoices

Driverless cars will improve our lives dramatically but, as with all technologies, there will be a dark side as millions of jobs disappear, Vivek Wadhwa, entrepreneur and academic, tells John Thornhill. See acast.com/privacy for privacy and opt-out information.

7 AM - 1 - Washington Post technology reporter Vivek Wadhwa on his piece: "Robots could eventually replace soldiers in warfare. Is that a good thing?". 2 - The 10 Habits Of Extremely Boring People. 3 - The News with Marshall Phillips. 4 - Does America really want a 3rd party?.

Academic, researcher, writer and serial entrepreneur Vivek Wadhwa, discusses advances in technology and urges entrepreneurs to focus on healthcare developments that can solve the world's health problems and make a difference.

7 AM - 1 - More Prince and stuff re: celebrity deaths. 2 - Washington Post's Vivek Wadhwa talks about his story: "How open science can help solve Zika and prepare us for the next pandemic". 3 - The News with Marshall Phillips. 4 - Curt Schilling fired stuff.

On our second show of 2016, we talk to notable academic, entrepreneur, author and think tank Vivek Wadhwa. Wadhwa was one of the first vocal advocates for a Startup Visa in the US. His book The Immigrant Exodus was the first that discussed the reverse brain drain issue. We are honored and privileged to have had the opportunity to speak with him. I hope you will enjoy this insightful discussion. Also on this show, we report on breaking news that the Supreme Court will hear the DACA/DAPA case. The case is about allowing undocumented people work authorization through executive action. Thank you to Vivek Wadhwa for joining us! Stay tuned for next week's show which promises to be exciting also. Thanks for listening!

8 AM - 1 - Mister Thrump went off on the NFL being too soft nowadays. 2 - Washington Post technology reporter Vivek Wadhwa talks about the "6 Technologies That Will Define 2016". 3 - The News with Marshall Phillips. 4 - Sean Penn met with El Chapo and then Chapo got caught!.

1 - Mister Thrump went off on the NFL being too soft nowadays. 2 - Washington Post technology reporter Vivek Wadhwa talks about the "6 Technologies That Will Define 2016". 3 - The News with Marshall Phillips; 4 - Sean Penn met with El Chapo and then Chapo got caught!

Vivek Wadhwa began as a software entrepreneur and now is a well-known speaker, writer, and Vice President of Academics and Innovation at Singularity University. In this interview, Mr. Wadhwa shares his heartfelt predictions about what he sees as the complete overhaul of healthcare and education in the coming decades ahead - and the widespread benefits of emerging technology for what he sees as a healthier and more informed future generation.

The last episode of TLDR was titled "Quiet, Wadhwa." It concerned a man named Vivek Wadhwa, but we did not ask him for comment. The episode was later removed. This week we look at the controversy we've become a part of and our role in it. To read Amelia Greenhall's original blog post, titled "Quiet, Ladies. @wadhwa is speaking," click here. To read Greenhall's post-podcast removal follow up, titled "I wrote about Vivek Wadhwa and you'll never guess what happened next!," click here. To read Vivek Wadhwa's rebuttal of episode #45 on Venture Beat, titled "My response to the podcast that unfairly attacked me," click here. To read Vivek Wadhwa's other response to the situation on South Asia Mail, titled "Perils of becoming a public figure," click here. To read Gawker and Gizmodo's coverage of the situation, click here and here. [Update: The Cate Huston article referenced was co-authored by Karen Catlin, and is notably titled "Tech’s Male ‘Feminists’ Aren’t Helping. To read, click here.]  

From tech entrepreneur to business owner, from accomplished academic to widely published writer, Vivek Wadhwa is an agent of innovation and disruption. His research, which has been supported by several grants from the Kauffman Foundation and by the Sloan Foundation, has been cited in thousands of national and international media outlets since 2007 and has...

TranscriptSpeaker 1: Spectrum's. Next. Speaker 2: N. N. N. N. Speaker 3: [inaudible].Speaker 1: Welcome to spectrum the science and technology show on k a l x, [00:00:30] Berkeley, a biweekly 30 minute program, bringing you interviews, featuring bay area scientists and technologists as well as a calendar of local events and news. Speaker 4: Good afternoon. I'm Rick Karnofsky. Brad swift and I are the hosts of today's show. Today we're talking with doctors, Tonya Wilkie and Chris Rink of the Department of Energy Joint Genome Institute in Walnut Creek. They recently published an article entitled insights into the Phylogeny and coding potential [00:01:00] of microbial dark matter in which they have to characterized through relationships between 201 different genomes and identified some unique genomic features. Tonya and Chris, welcome to spectrum. Speaker 5: Thanks for having us. Thank you. Speaker 4: So Tanya, what is microbial dark matter? Speaker 5: We like to take life as we know it and put it in an evolutionary tree in a tree of life. And what this assists us is to figure out the evolutionary histories of organisms and the relationships between [00:01:30] related groups of organisms. So what does this mean? It's to say we take microbial diversity as we know it on this planet and we place it in this tree of life. What you will find is that there will be some major branches in this tree, about 30 of them, and we call these major branches Fila that are made up of organisms that you can cultivate. So we can grow them on plates in the laboratory, we can grow them in Allen Meyer, flask and liquid media. We can study that for CLG. We can figure out what substrates they metabolize, [00:02:00] we can figure out how they behave under different conditions. Speaker 5: Many of them we can even genetically modify. So we really know a lot about these organisms and we can really figure out, you know, how do they function, what are the genetic underpinnings that make them function the way they do in the laboratory and also in the environment where they come from. So now coming back to this tree of life, if you keep looking at this tree of life, uh, we will find at least another 30 off these major branches that we refer to as [00:02:30] Canada. Dot. Sila and these branches have no cultivators, representatives, so all the organisms that make up these branches, we have not yet been able to cultivate in the laboratory. We call these kind of dot, Fila or microbial dark matter. And the term dark matter. All biological dark matter has been coined by the Steve Craig Laboratory at Stanford University when they published the first genomes after a candidate, phylum TM seven. We know that dark matter is in most if not all [00:03:00] ecosystems. So we find it in most ecosystems, but to get at their complete genetic makeup. That's the key challenge. Speaker 4: Yeah. And if you, if you want to push it through the extreme, there are studies out there estimating the number of bacteria species they are and how many we can cultivate. And the result is all there. The estimation of the studies we can cultivate about, you know, one or 2% of all the microbial species out there. So basically nine to 9% is still out there and we haven't even looked at it. So this really, this major on culture microbes and majority is [00:03:30] still waiting out there to be explored. So that sort of carries on the analogy to cosmological dark matter in which there's much more of it than what we actually see and understand. Right. Speaker 5: So how common and how prevalent are, are these dark matter organisms? Yeah, that's a really good question. So in some environments they are what we would consider the rabbi biosphere. So they are actually at fairly low abundance, but our methods are sensitive enough to still pick them up. [00:04:00] In other environments. We had some sediment samples where some of these candidate file, our, actually what we would consider quite abandoned, it's a few percent, let's say 2% of opiate candidate phylum that to us, even 2% is quite abandoned. Again, you have to consider the whole community. And if one member is a 2%, that's, that's a pretty dominant community members. So I'd arise from environment, environment Speaker 4: and Chris, where were samples collected from? So altogether we sampled nine sampling sites all over the globe [00:04:30] and we tried to be as inclusive as possible. So we had marine samples, freshwater samples, sediment samples, um, some samples from habitats with very high temperatures and also a sample from a bioreactor. And there were a few samples among them that for which we had really great hopes. And among them were um, samples from the hot vans from the bottom of Pacific Ocean. The samples we got were from the East Pacific virus sampling side, and that's about 2,500 meters below the store phase. And [00:05:00] the sample there, you really need a submersible that's a small submarine and you can launch from a research vessel. In our case, those samples were taken by Elvin from the woods hole oceanographic institution and now you have a lot of full Canik activity and also the seawater seeps into the earth crust goes pretty deep and gets heated up. Speaker 4: And when it comes back out as a hydrothermal event, it has up to [inaudible] hundred 50 to 400 degrees Celsius. And it is enriched in chemicals such as a sulfur or iron. [00:05:30] It makes us immediately with the surrounding seawater, which is only about a two degrees Celsius. So it's a very, it's a very challenging environment because you have this gradient from two degrees to like 400 degrees within a few centimeters and you have those chemicals that uh, the organisms, the micro organisms could use blast. There is no sunlight. So we thought that's a very interesting habitat to look for. Microbial, dark matter. There were several samples. That's a to us. One of them is the Homestake [00:06:00] mine in South Dakota and that's an old gold mine that is not used anymore since 2002 but are there still scientific experiments going on there? It's a very deep mine, about 8,000 feet deep and we could all sample from about 300 feet. Speaker 4: And we were surprised about this Ikea diversity we found in those samples. There were a few Akia that were not close to any, I don't know another key out there for some of them. We even had to propose new archaeal Fila. Stepping back a bit, Chris, [00:06:30] can you tell us more about Ikea and perhaps the three domains of life? The three domains were really established by Culver's with his landmark paper in 1977 and what he proposed was a new group of Derek here. So then he had all together three domains. You had the bacteria and archaea and the eukaryotes, the eukaryote state. There are different one big differences to have the nucleus, right? They have to DNA in the nucleus and it also includes all the higher taxa. But then you have also their key and the bacteria. [00:07:00] And those are two groups that only single cell organisms, but they are very distant related to each other, the cell envelope, all. And also the cell duplication machinery of the archaea is closer to the eukaryotes than it is to the bacteria. Speaker 5: Yeah, and it's interesting, I mean Ikea, I guess we haven't sequenced some that much yet, but Ikea are very important too, but people are not aware of them. They know about bacteria, but Ikea and maybe because there aren't any RKO pathogen [00:07:30] and we'd like to think about bacteria with regards to human health, it's very important. That's why most of what we sequence are actually pathogens, human pathogens. So we sequence, I don't know how many strains of your senior pastors and other pathogenic bacteria, but archaea are equally important, at least in the environment. But because we rarely find them associated with humans, we don't really think about archaea much. Our people aren't really aware of Ikea. Speaker 4: Talk about their importance, Speaker 5: the importance [00:08:00] in the environment. So Ikea are, for example, found in extreme environments. We find them in Hydro Soma environments. We find them in hot springs. Uh, we, they have, they have biotechnological importance and not a lot of, quite useful in enzymes that are being used in biotechnology are derived from Ikea in part because we find them in these extreme environments and hot environments and they have the machinery to deal with this temperature. So they have enzymes that function [00:08:30] properly at high temperature and extreme conditions, really extreme on the commerce extreme or fields. And that makes them very attractive bio technologically because some of these enzymes that we would like to use should be still more tolerant or should have these features that are sort of more extreme. Um, so we can explain it them for a biotech technological applications. [inaudible] Speaker 6: [inaudible] [00:09:00] you are listening to spectrum on k l x Berkeley. I'm Rick [inaudible] and I'm talking with Kanya vulgate and Chris, her and Kate about using single cell genomics. You're expand our knowledge that the tree of life, Speaker 5: [00:09:30] so again, we called up a range of different collaborators and they were all willing to go back to these interesting sites, even to the hydrothermal vent and get us fresh sample. No one turned us down. So we, we, we screened them again to make sure they are really of the nature that we would like to have them and the ones that were suitable. We then fed into our single cell workflow. Can you talk briefly about that screening? There were two screens in waft. One screen was narrowing down the samples themselves and we received a lot more sample, I would say at least [00:10:00] three times as many sample as we ended up using. And we pre-screened these on a sort of barcode sequencing level. And so we down selected them to about a third. And then within this third we sorted about 9,000 single cells and within these 9,000 single cells, only a subset of them went through successful single cell, whole genome amplification. And out of that set then we were only, we were able to identify another subset. And [00:10:30] in the end we selected 200 for sequencing 201 Speaker 4: and how does single cell sequencing work? Speaker 5: So to give you a high level overview, you take a single cell directly from the environment, you isolate it, and there's different methodologies to do that. And then you break it open, you expose the genetic material within the cell, the genome, and then you amplify the genome. And some single cells will only have one copy of that genome. And we have a methodology, it's a whole genome amplification process that's called multiple displacement amplification [00:11:00] or MDA. And that allows us to make from one copy of the genome, millions and billions of copies. One copy of the genome corresponds to a few family or grams of DNA. We can do much with it. So we have to multiply, we have to make these millions and billions of copies of the genome to have sufficient DNA for next generation sequencing. Speaker 4: Are there other extreme environments that you guys didn't take advantage of in this study that might be promising? Definitely. Um, so we, [00:11:30] we created the list already off environments that would be interesting to us based on, you know, on the results from the last start in the experience we have with environmental conditions and the is microbes we've got out of it. So we're definitely planning to have a followup study where we explore all those, um, habitats that we couldn't include in this, uh, study. Speaker 5: So some examples of the Red Sea and some fjords in Norway and their various that were after Speaker 4: the, that the Black Sea is a very interesting environment too. It's, it's completely anoxic, high levels of sulfide [00:12:00] and it's, it's really, it's huge. So that's a very interesting place to sample too. And how historically have we come to this tree in the old days? And I mean the, the, the pre sequencing area, um, the main criteria that scientists use to categorize organisms whilst the phenotype. That's the, the morphology, the biochemical properties, the development. And that was used to put, uh, organisms into categories. And then with the dawn of the sequencing area, and that was [00:12:30] mainly, um, pushed by the Sanger sequencing, the development of the Sanger sequencing in the 70s. We finally had another and we could use and that was the DNA sequence of organisms. And that was used to classify and categorize organisms. Does a phenotyping still play a role in modern phylogeny? It still does play a role in modern philosophy in the, especially for eukaryotes. Speaker 4: Well you have a very significant phenotype. So what you do there is you can compare a phenotyping information with the [00:13:00] genomic information and on top of that even, uh, information from all the ontology and you try to combine all the information you have doing for, let's say, for the evolutionary relationships among those organisms in modern times, the phylogeny of bacteria, Nokia, it's mainly based on molecular data. Part of our results were used to infer phylogenetic relationships into the started. The evolutionary history of those microbes. We'll be, well do you have for the first time is we now have chine [00:13:30] ohms for a lot of those branches of the tree where before we only had some barcodes so we knew they were there, but we had no information about the genomic content and they'll seem to be hafted for the first time. We can actually look at the evolutionary history of those microbes and there were two, two main findings in our paper. Speaker 4: One was that for a few groups, the f the placement that taxonomic placement in the tree of life was kind of debated in the past. We could help to clarify that. For example, one group is they clock chemo needs [00:14:00] and it was previously published. It could be part of the farm of the spiral kids, but we could Cully show with our analysis that they are their own major branch entry of laughter or their own file them and a a second result. That's, I think it's very important that that's because they didn't share a lot of jeans with others. Bifurcates is that, that's, that's right. So if you placed him in a tree of life, you can see that the don't cluster close parakeets, they'll come out on the other side by out by themselves, not much resembling if the spark is there. And the second result was [00:14:30] that, uh, we found several of those main branches of the tree of life, those Fila the class of together consistently in our analysis. Speaker 4: And so we could group them together and assign super filer to them. One example is a sweet book, Zero Fila Debra Opa 11 or the one and Chino too, and also almost clustered together. So we proposed a super final name. Potesky and Potesky means I'm bear or simple. And we choose that because they have a reduced and streamlined genome. That's another common feature. [00:15:00] I'm Andrea and I, I have to say that, you know, looking into evolutionary relationships, it is, it is a moving target because as Tanya mentioned, especially for microbes and bacteria and like here, there's still so many, um, candidates that are out there for which we have no genomic information. So we definitely need way more sequences, um, to get a better idea of the evolutionary relationships of all the books. Your Nokia out there Speaker 6: [00:15:30] spectrum is a public affairs show about science on k a l x Berkeley. Our guests today are Tanya. Okay. And Chris Rink k you single cell genomics to find the relationships between hundreds of dark matter of microbes. Speaker 4: And can you speak to the current throughput? I would have thought that gathering up organisms in such extreme environments was really the time limiting factor. [00:16:00] But I suppose if you have this archive, other steps might end up taking a while. I will say the most time consuming step is really to to sort those single cells and then to lyse the single cells and amplify the genome and then of course to screen them for the, for genomes of interest for microbial like metagenomes [inaudible] that was a big part of the study. So actually getting the genomic information out of the single cells and if that can be even more streamlined than uh, and push to a higher or even more stupid level, I think [00:16:30] that will speed up the recovery of, of novel microbial dogmatic genomes quite a bit. Speaker 5: Well, we have a pretty sophisticated pipeline now at the JGI where we can do this at a fairly high throughput, but as Chris said, it still takes time and every sample is different. Every sample behaves different depending on what the properties of the samples are. You may have to be treated in a certain way to make it most successful for this application and other staff in the whole process that takes a long time is the key. The quality control [00:17:00] of the data. So the data is not as pretty as a sequencing data from an isolet genome where you get a perfect genome back and the sequence data that you get back is fairly, even the coverage covered all around the genome. Single cell data is messy. The amplification process introduces these artifacts and issues. It can introduce some error because you're making copies of a genome. Speaker 5: So errors can happen. You can also introduce what we call comeric rearrangement. That means that pieces of DNA [00:17:30] go together that shouldn't go together. Again, that happens during the amplification process. It's just the nature of the process. And on top of that, parts of the genome amplify nicely and other parts not so nice. So the overall sort of what we call sequence coverage is very uneven. So the data is difficult to deal with. We have specific assembly pipelines that we do. We do a sort of a digital normalization of the data before we even deal with the data, so it's not as nice. And then on top of that you can have contamination. So the whole process is very [00:18:00] prone to contamination. Imagine you only have one copy of a single cell, five Phantogram, one circle of DNA and any little piece of DNA that you have in that prep that sometimes as we know comes with the reagents. Speaker 5: Because reagents are not designed to deal with such low template molecules. They will call amplify, they will out-compete or compete with your template. So what you end up with in your sequence is your target and other stuff that was in was in the reagents or again, in your prep. We have very rigorous [00:18:30] process of cleaning everything. We you read a lot of things we sterilize, so we need to get rid of any DNA to not, um, to, to have a good quality genome in the end. And so that said, we have developed tools and pipelines at our institute now that specifically help us detect contamination. Sometimes it's not easy to detect it and then remove it. We want to make sure that the single cell genomes that we released at as single cell genome ABC are really ABC and not a plus x and [00:19:00] B plus k because accidentally something came along and contaminated the prep. And especially with candidate Fila, it's, it's fairly difficult to detect tech contamination because what would help us would be if we would have referenced genomes, we're actually generating this reference genome so we don't have a good reference to say, yeah, this is actually, that's our target organism and the rest is public contamination, so it's very tricky. Speaker 4: Are there other examples for [00:19:30] single cell sequencing being used on this many organisms Speaker 5: on this many organisms? No, not that I'm aware of. I know there's an effort underway and the h and p, the human microbiome project where they also identified there, they nicely call it the most wanted list, so they have the target organisms that are quite abundant in different microbiomes within the human body associated with the human body and they've been very successfully able to cultivate. A lot of them bring a lot of them in culture [00:20:00] and it may be easier for the h and p because we can mimic the conditions within the body a little bit better and more controlled. We know our body temperature and we know sort of what the middle year is in the different parts of our body. So it's a little bit easier to bring these organisms and culture than going to the hydrothermal vent and try and recreate these conditions which are extremely difficult to recreate. So that said, um, there are some that they are now targeting with single cell sequencing. So that's another large effort [00:20:30] that I know of that's specifically using single cell genomics to get at some of these reference genomes. Speaker 4: Can you get more out of this then? Sort of phylogenetic links? We found a few unique genomic features and one on one dimension is we found a recode. It's stopped caught on in, in two of those, a bacteria from the hot vans I mentioned earlier. And to give you a little bit of background, so, um, it's, we know the genetic information of each sale is and coded in its DNA, but in order to [00:21:00] make use of this genomic information, this genetic information has to be translated into proteins. And then proteins that could be enzymes that are employed in the metabolism to keep the cell going. And a dispensation is pretty universal between the three domains of life. The way it works, we have three basis in your DNA and three basis are called the core done. And each call is translated in the one amino acid. Speaker 4: So this way you'll build a chain of amino acids and then this chain is for a folder [00:21:30] and then you have your ready made protein. This call them triplet. This three basis also work for start and stop. So there are certain colons that tell the cell, okay, that's where you start a protein. And another called in to tell us the cell. So that's, that's where you enter prod and you're done with it. There are some slight variations, but in general does a universally called, is perceived between all three domains of life. And what we found was very interesting in two of those bacteria from the hot vans. Ah, those two caecilian bacteria, we found the [00:22:00] recording. So one of the accord on did not called for a stop code on anymore, but in the quarter's for an amino acid in that case, glycine. And that has never been seen before. Were you surprised by these results? Speaker 5: To us, they were surprising because they were unique and they were different. On the other hand, I have to say I'm not that surprised because we haven't, like Russ said, we haven't looked at heart yet and considering that we can only cultivate a few percent of all the microbial diversity that exists on this planet as far as, [00:22:30] as far as we know it, it's not that surprising that you find these novel functions and there's these unique features and novel genetic codes because it's really, it's a highly under-explored area. Speaker 4: It is very rewarding. But if you look in the future, um, how much is still out of the sequence? Of course we're interested in that. So we looked at all the files show diversity that's known, that's out there based on this, um, biomarkers that Tony mentioned earlier and we just compared it to the genomes that we have sequenced so far. And we really want [00:23:00] to know, so if you want to cover let's say about 50% of all the fall diversity that's out there, how many achievements do we still have to sequence and the number of the estimate was we need to sequence at least 16,004 more genomes Speaker 5: and this is a moving target. So this is as we know, diversity of today it and every day we sample my environments, we sequence them deeper and everyday our diversity estimates increase. So what we've done with these 201 it's the tip of the iceberg but it's a start. Speaker 4: [00:23:30] Well Tanya and Chris, thanks for joining us. Thanks for having us. Thanks for having us. Yeah. Speaker 6: [inaudible] that's what shows are archived on iTunes to you. We've queued a simple link for you. The link is tiny, url.com/calex Speaker 7: spectrum Speaker 8: irregular feature of spectrum is a calendar [00:24:00] of some of the science and technology related events happening in the bay area over the next two weeks. Here's Brad swift and Renee Rao here today. Majority tomorrow. Expanding technological inclusion, technological inclusion is not an issue for some of us. It is an issue for all of us. Mitchell Kapore, co-chair of [inaudible] center for social impact and a partner at Kapore capital. We'll moderate a panel discussion among the following [00:24:30] presenters, Jennifer r Guayle, executive director of Latino to Kimberly Bryant, founder of Black Girls Code Connie Mack Keebler, a venture capitalist with the collaborative fund. Vivek Wadhwa academic researcher, writer and entrepreneur here today. Majority tomorrow is free and open to everyone on a first come first seated basis. This is happening on the UC Berkeley campus in Soutar de Di Hall [inaudible] [00:25:00] Auditorium Monday October 7th at 4:00 PM Speaker 7: the second installment of the six part public lecture series, not on the test. The pleasure and uses of mathematics will be held this October 9th Dr. Keith Devlin will deliver a lecture on underlying mathematics in video games. Dr Devlin will show how casual video games that provide representation of mathematics enabled children and adults to learn basic mathematics by playing in the same way people [00:25:30] learn music by learning to play the piano. Professor Devlin is a mathematician at Stanford, a Co founder and president of Inner Tube Games and the math guy of NPR. The lecture will be held on October 9th at 7:00 PM in the Berkeley City College Auditorium located at 2050 Center street in Berkeley. The event is free and open to the public. Speaker 8: The Leonardo arts science evening rendezvous or laser is a lecture series with rotating barrier venues. October 9th there will be a laser [00:26:00] at UC Berkeley. Presenters include Zan Gill, a former NASA scientists, Jennifer Parker of UC Santa Cruz, Cheryl Leonard, a composer, Wayne Vitali, founding member of gamelons Sakara [inaudible]. This is Wednesday, October 9th from 6:30 PM to 9:00 PM on the UC Berkeley campus in barrels hall room 100 Speaker 7: how can we prevent information technology [00:26:30] from destroying the middle class? Jaron Lanier, is it computer scientists, Kim Poser, visual artist and author. October 14th linear will present his ideas on the impact of information technology on his two most recent books are title. You are not a gadget and who owns the future. The seminar will be held in Sue Taja, Dai Hall, but not auditorium on the UC Berkeley campus. Monday, October 14th from 11:00 AM to noon [00:27:00] and that with some science news headlines. Here's the Renee, the intergovernmental panel on climate change released part of its assessment report. Five last Friday. The more than 200 lead authors on their report included Lawrence Berkeley National Labs, Michael Warner and William Collins who had a chapters on longterm climate change productions and climate models. The report reinforces previous conclusions that over the next century, the continents will warm [00:27:30] with more hot extremes and fewer cold extremes. Precipitation patterns around the world will also continue changing. One-Arm Collins noted that climate models since the last report in 2007 have improved significantly as both data collection and mechanistic knowledge have grown using these models. Scientists made several projections of different scenarios for the best, worst and middling cases of continued greenhouse emissions. Speaker 7: [00:28:00] Two recent accomplishments by commercial space programs are notable. Orbital Sciences launched their sickness spacecraft on September 18th a top the company's rocket and Tara's from wallops island, Virginia. On September 28th the Cygnus dock did the international space station for the first time, a space x rocket carrying and Canadian satellite has launched from the California coast in a demonstration flight of a new Falcon rocket. The next generation. Rocket boasts [00:28:30] upgraded engines designed to improve performance and carry heavier payloads. The rocket is carrying a satellite dead kiss IOP, a project of the Canadian Space Agency and other partners. Once in orbit it will track space weather. Speaker 2: Mm mm mm. Mm Huh. Speaker 7: The music [00:29:00] heard during the show was written and produced by Alex Simon. Yeah. Speaker 3: Thank you for listening to spectrum. If you have comments about the show, please send them to us via email. Address is [inaudible] dot [inaudible] dot com Speaker 9: [inaudible]. Hosted on Acast. See acast.com/privacy for more information.

TranscriptSpeaker 1: Spectrum's. Next. Speaker 2: N. N. N. N. Speaker 3: [inaudible].Speaker 1: Welcome to spectrum the science and technology show on k a l x, [00:00:30] Berkeley, a biweekly 30 minute program, bringing you interviews, featuring bay area scientists and technologists as well as a calendar of local events and news. Speaker 4: Good afternoon. I'm Rick Karnofsky. Brad swift and I are the hosts of today's show. Today we're talking with doctors, Tonya Wilkie and Chris Rink of the Department of Energy Joint Genome Institute in Walnut Creek. They recently published an article entitled insights into the Phylogeny and coding potential [00:01:00] of microbial dark matter in which they have to characterized through relationships between 201 different genomes and identified some unique genomic features. Tonya and Chris, welcome to spectrum. Speaker 5: Thanks for having us. Thank you. Speaker 4: So Tanya, what is microbial dark matter? Speaker 5: We like to take life as we know it and put it in an evolutionary tree in a tree of life. And what this assists us is to figure out the evolutionary histories of organisms and the relationships between [00:01:30] related groups of organisms. So what does this mean? It's to say we take microbial diversity as we know it on this planet and we place it in this tree of life. What you will find is that there will be some major branches in this tree, about 30 of them, and we call these major branches Fila that are made up of organisms that you can cultivate. So we can grow them on plates in the laboratory, we can grow them in Allen Meyer, flask and liquid media. We can study that for CLG. We can figure out what substrates they metabolize, [00:02:00] we can figure out how they behave under different conditions. Speaker 5: Many of them we can even genetically modify. So we really know a lot about these organisms and we can really figure out, you know, how do they function, what are the genetic underpinnings that make them function the way they do in the laboratory and also in the environment where they come from. So now coming back to this tree of life, if you keep looking at this tree of life, uh, we will find at least another 30 off these major branches that we refer to as [00:02:30] Canada. Dot. Sila and these branches have no cultivators, representatives, so all the organisms that make up these branches, we have not yet been able to cultivate in the laboratory. We call these kind of dot, Fila or microbial dark matter. And the term dark matter. All biological dark matter has been coined by the Steve Craig Laboratory at Stanford University when they published the first genomes after a candidate, phylum TM seven. We know that dark matter is in most if not all [00:03:00] ecosystems. So we find it in most ecosystems, but to get at their complete genetic makeup. That's the key challenge. Speaker 4: Yeah. And if you, if you want to push it through the extreme, there are studies out there estimating the number of bacteria species they are and how many we can cultivate. And the result is all there. The estimation of the studies we can cultivate about, you know, one or 2% of all the microbial species out there. So basically nine to 9% is still out there and we haven't even looked at it. So this really, this major on culture microbes and majority is [00:03:30] still waiting out there to be explored. So that sort of carries on the analogy to cosmological dark matter in which there's much more of it than what we actually see and understand. Right. Speaker 5: So how common and how prevalent are, are these dark matter organisms? Yeah, that's a really good question. So in some environments they are what we would consider the rabbi biosphere. So they are actually at fairly low abundance, but our methods are sensitive enough to still pick them up. [00:04:00] In other environments. We had some sediment samples where some of these candidate file, our, actually what we would consider quite abandoned, it's a few percent, let's say 2% of opiate candidate phylum that to us, even 2% is quite abandoned. Again, you have to consider the whole community. And if one member is a 2%, that's, that's a pretty dominant community members. So I'd arise from environment, environment Speaker 4: and Chris, where were samples collected from? So altogether we sampled nine sampling sites all over the globe [00:04:30] and we tried to be as inclusive as possible. So we had marine samples, freshwater samples, sediment samples, um, some samples from habitats with very high temperatures and also a sample from a bioreactor. And there were a few samples among them that for which we had really great hopes. And among them were um, samples from the hot vans from the bottom of Pacific Ocean. The samples we got were from the East Pacific virus sampling side, and that's about 2,500 meters below the store phase. And [00:05:00] the sample there, you really need a submersible that's a small submarine and you can launch from a research vessel. In our case, those samples were taken by Elvin from the woods hole oceanographic institution and now you have a lot of full Canik activity and also the seawater seeps into the earth crust goes pretty deep and gets heated up. Speaker 4: And when it comes back out as a hydrothermal event, it has up to [inaudible] hundred 50 to 400 degrees Celsius. And it is enriched in chemicals such as a sulfur or iron. [00:05:30] It makes us immediately with the surrounding seawater, which is only about a two degrees Celsius. So it's a very, it's a very challenging environment because you have this gradient from two degrees to like 400 degrees within a few centimeters and you have those chemicals that uh, the organisms, the micro organisms could use blast. There is no sunlight. So we thought that's a very interesting habitat to look for. Microbial, dark matter. There were several samples. That's a to us. One of them is the Homestake [00:06:00] mine in South Dakota and that's an old gold mine that is not used anymore since 2002 but are there still scientific experiments going on there? It's a very deep mine, about 8,000 feet deep and we could all sample from about 300 feet. Speaker 4: And we were surprised about this Ikea diversity we found in those samples. There were a few Akia that were not close to any, I don't know another key out there for some of them. We even had to propose new archaeal Fila. Stepping back a bit, Chris, [00:06:30] can you tell us more about Ikea and perhaps the three domains of life? The three domains were really established by Culver's with his landmark paper in 1977 and what he proposed was a new group of Derek here. So then he had all together three domains. You had the bacteria and archaea and the eukaryotes, the eukaryote state. There are different one big differences to have the nucleus, right? They have to DNA in the nucleus and it also includes all the higher taxa. But then you have also their key and the bacteria. [00:07:00] And those are two groups that only single cell organisms, but they are very distant related to each other, the cell envelope, all. And also the cell duplication machinery of the archaea is closer to the eukaryotes than it is to the bacteria. Speaker 5: Yeah, and it's interesting, I mean Ikea, I guess we haven't sequenced some that much yet, but Ikea are very important too, but people are not aware of them. They know about bacteria, but Ikea and maybe because there aren't any RKO pathogen [00:07:30] and we'd like to think about bacteria with regards to human health, it's very important. That's why most of what we sequence are actually pathogens, human pathogens. So we sequence, I don't know how many strains of your senior pastors and other pathogenic bacteria, but archaea are equally important, at least in the environment. But because we rarely find them associated with humans, we don't really think about archaea much. Our people aren't really aware of Ikea. Speaker 4: Talk about their importance, Speaker 5: the importance [00:08:00] in the environment. So Ikea are, for example, found in extreme environments. We find them in Hydro Soma environments. We find them in hot springs. Uh, we, they have, they have biotechnological importance and not a lot of, quite useful in enzymes that are being used in biotechnology are derived from Ikea in part because we find them in these extreme environments and hot environments and they have the machinery to deal with this temperature. So they have enzymes that function [00:08:30] properly at high temperature and extreme conditions, really extreme on the commerce extreme or fields. And that makes them very attractive bio technologically because some of these enzymes that we would like to use should be still more tolerant or should have these features that are sort of more extreme. Um, so we can explain it them for a biotech technological applications. [inaudible] Speaker 6: [inaudible] [00:09:00] you are listening to spectrum on k l x Berkeley. I'm Rick [inaudible] and I'm talking with Kanya vulgate and Chris, her and Kate about using single cell genomics. You're expand our knowledge that the tree of life, Speaker 5: [00:09:30] so again, we called up a range of different collaborators and they were all willing to go back to these interesting sites, even to the hydrothermal vent and get us fresh sample. No one turned us down. So we, we, we screened them again to make sure they are really of the nature that we would like to have them and the ones that were suitable. We then fed into our single cell workflow. Can you talk briefly about that screening? There were two screens in waft. One screen was narrowing down the samples themselves and we received a lot more sample, I would say at least [00:10:00] three times as many sample as we ended up using. And we pre-screened these on a sort of barcode sequencing level. And so we down selected them to about a third. And then within this third we sorted about 9,000 single cells and within these 9,000 single cells, only a subset of them went through successful single cell, whole genome amplification. And out of that set then we were only, we were able to identify another subset. And [00:10:30] in the end we selected 200 for sequencing 201 Speaker 4: and how does single cell sequencing work? Speaker 5: So to give you a high level overview, you take a single cell directly from the environment, you isolate it, and there's different methodologies to do that. And then you break it open, you expose the genetic material within the cell, the genome, and then you amplify the genome. And some single cells will only have one copy of that genome. And we have a methodology, it's a whole genome amplification process that's called multiple displacement amplification [00:11:00] or MDA. And that allows us to make from one copy of the genome, millions and billions of copies. One copy of the genome corresponds to a few family or grams of DNA. We can do much with it. So we have to multiply, we have to make these millions and billions of copies of the genome to have sufficient DNA for next generation sequencing. Speaker 4: Are there other extreme environments that you guys didn't take advantage of in this study that might be promising? Definitely. Um, so we, [00:11:30] we created the list already off environments that would be interesting to us based on, you know, on the results from the last start in the experience we have with environmental conditions and the is microbes we've got out of it. So we're definitely planning to have a followup study where we explore all those, um, habitats that we couldn't include in this, uh, study. Speaker 5: So some examples of the Red Sea and some fjords in Norway and their various that were after Speaker 4: the, that the Black Sea is a very interesting environment too. It's, it's completely anoxic, high levels of sulfide [00:12:00] and it's, it's really, it's huge. So that's a very interesting place to sample too. And how historically have we come to this tree in the old days? And I mean the, the, the pre sequencing area, um, the main criteria that scientists use to categorize organisms whilst the phenotype. That's the, the morphology, the biochemical properties, the development. And that was used to put, uh, organisms into categories. And then with the dawn of the sequencing area, and that was [00:12:30] mainly, um, pushed by the Sanger sequencing, the development of the Sanger sequencing in the 70s. We finally had another and we could use and that was the DNA sequence of organisms. And that was used to classify and categorize organisms. Does a phenotyping still play a role in modern phylogeny? It still does play a role in modern philosophy in the, especially for eukaryotes. Speaker 4: Well you have a very significant phenotype. So what you do there is you can compare a phenotyping information with the [00:13:00] genomic information and on top of that even, uh, information from all the ontology and you try to combine all the information you have doing for, let's say, for the evolutionary relationships among those organisms in modern times, the phylogeny of bacteria, Nokia, it's mainly based on molecular data. Part of our results were used to infer phylogenetic relationships into the started. The evolutionary history of those microbes. We'll be, well do you have for the first time is we now have chine [00:13:30] ohms for a lot of those branches of the tree where before we only had some barcodes so we knew they were there, but we had no information about the genomic content and they'll seem to be hafted for the first time. We can actually look at the evolutionary history of those microbes and there were two, two main findings in our paper. Speaker 4: One was that for a few groups, the f the placement that taxonomic placement in the tree of life was kind of debated in the past. We could help to clarify that. For example, one group is they clock chemo needs [00:14:00] and it was previously published. It could be part of the farm of the spiral kids, but we could Cully show with our analysis that they are their own major branch entry of laughter or their own file them and a a second result. That's, I think it's very important that that's because they didn't share a lot of jeans with others. Bifurcates is that, that's, that's right. So if you placed him in a tree of life, you can see that the don't cluster close parakeets, they'll come out on the other side by out by themselves, not much resembling if the spark is there. And the second result was [00:14:30] that, uh, we found several of those main branches of the tree of life, those Fila the class of together consistently in our analysis. Speaker 4: And so we could group them together and assign super filer to them. One example is a sweet book, Zero Fila Debra Opa 11 or the one and Chino too, and also almost clustered together. So we proposed a super final name. Potesky and Potesky means I'm bear or simple. And we choose that because they have a reduced and streamlined genome. That's another common feature. [00:15:00] I'm Andrea and I, I have to say that, you know, looking into evolutionary relationships, it is, it is a moving target because as Tanya mentioned, especially for microbes and bacteria and like here, there's still so many, um, candidates that are out there for which we have no genomic information. So we definitely need way more sequences, um, to get a better idea of the evolutionary relationships of all the books. Your Nokia out there Speaker 6: [00:15:30] spectrum is a public affairs show about science on k a l x Berkeley. Our guests today are Tanya. Okay. And Chris Rink k you single cell genomics to find the relationships between hundreds of dark matter of microbes. Speaker 4: And can you speak to the current throughput? I would have thought that gathering up organisms in such extreme environments was really the time limiting factor. [00:16:00] But I suppose if you have this archive, other steps might end up taking a while. I will say the most time consuming step is really to to sort those single cells and then to lyse the single cells and amplify the genome and then of course to screen them for the, for genomes of interest for microbial like metagenomes [inaudible] that was a big part of the study. So actually getting the genomic information out of the single cells and if that can be even more streamlined than uh, and push to a higher or even more stupid level, I think [00:16:30] that will speed up the recovery of, of novel microbial dogmatic genomes quite a bit. Speaker 5: Well, we have a pretty sophisticated pipeline now at the JGI where we can do this at a fairly high throughput, but as Chris said, it still takes time and every sample is different. Every sample behaves different depending on what the properties of the samples are. You may have to be treated in a certain way to make it most successful for this application and other staff in the whole process that takes a long time is the key. The quality control [00:17:00] of the data. So the data is not as pretty as a sequencing data from an isolet genome where you get a perfect genome back and the sequence data that you get back is fairly, even the coverage covered all around the genome. Single cell data is messy. The amplification process introduces these artifacts and issues. It can introduce some error because you're making copies of a genome. Speaker 5: So errors can happen. You can also introduce what we call comeric rearrangement. That means that pieces of DNA [00:17:30] go together that shouldn't go together. Again, that happens during the amplification process. It's just the nature of the process. And on top of that, parts of the genome amplify nicely and other parts not so nice. So the overall sort of what we call sequence coverage is very uneven. So the data is difficult to deal with. We have specific assembly pipelines that we do. We do a sort of a digital normalization of the data before we even deal with the data, so it's not as nice. And then on top of that you can have contamination. So the whole process is very [00:18:00] prone to contamination. Imagine you only have one copy of a single cell, five Phantogram, one circle of DNA and any little piece of DNA that you have in that prep that sometimes as we know comes with the reagents. Speaker 5: Because reagents are not designed to deal with such low template molecules. They will call amplify, they will out-compete or compete with your template. So what you end up with in your sequence is your target and other stuff that was in was in the reagents or again, in your prep. We have very rigorous [00:18:30] process of cleaning everything. We you read a lot of things we sterilize, so we need to get rid of any DNA to not, um, to, to have a good quality genome in the end. And so that said, we have developed tools and pipelines at our institute now that specifically help us detect contamination. Sometimes it's not easy to detect it and then remove it. We want to make sure that the single cell genomes that we released at as single cell genome ABC are really ABC and not a plus x and [00:19:00] B plus k because accidentally something came along and contaminated the prep. And especially with candidate Fila, it's, it's fairly difficult to detect tech contamination because what would help us would be if we would have referenced genomes, we're actually generating this reference genome so we don't have a good reference to say, yeah, this is actually, that's our target organism and the rest is public contamination, so it's very tricky. Speaker 4: Are there other examples for [00:19:30] single cell sequencing being used on this many organisms Speaker 5: on this many organisms? No, not that I'm aware of. I know there's an effort underway and the h and p, the human microbiome project where they also identified there, they nicely call it the most wanted list, so they have the target organisms that are quite abundant in different microbiomes within the human body associated with the human body and they've been very successfully able to cultivate. A lot of them bring a lot of them in culture [00:20:00] and it may be easier for the h and p because we can mimic the conditions within the body a little bit better and more controlled. We know our body temperature and we know sort of what the middle year is in the different parts of our body. So it's a little bit easier to bring these organisms and culture than going to the hydrothermal vent and try and recreate these conditions which are extremely difficult to recreate. So that said, um, there are some that they are now targeting with single cell sequencing. So that's another large effort [00:20:30] that I know of that's specifically using single cell genomics to get at some of these reference genomes. Speaker 4: Can you get more out of this then? Sort of phylogenetic links? We found a few unique genomic features and one on one dimension is we found a recode. It's stopped caught on in, in two of those, a bacteria from the hot vans I mentioned earlier. And to give you a little bit of background, so, um, it's, we know the genetic information of each sale is and coded in its DNA, but in order to [00:21:00] make use of this genomic information, this genetic information has to be translated into proteins. And then proteins that could be enzymes that are employed in the metabolism to keep the cell going. And a dispensation is pretty universal between the three domains of life. The way it works, we have three basis in your DNA and three basis are called the core done. And each call is translated in the one amino acid. Speaker 4: So this way you'll build a chain of amino acids and then this chain is for a folder [00:21:30] and then you have your ready made protein. This call them triplet. This three basis also work for start and stop. So there are certain colons that tell the cell, okay, that's where you start a protein. And another called in to tell us the cell. So that's, that's where you enter prod and you're done with it. There are some slight variations, but in general does a universally called, is perceived between all three domains of life. And what we found was very interesting in two of those bacteria from the hot vans. Ah, those two caecilian bacteria, we found the [00:22:00] recording. So one of the accord on did not called for a stop code on anymore, but in the quarter's for an amino acid in that case, glycine. And that has never been seen before. Were you surprised by these results? Speaker 5: To us, they were surprising because they were unique and they were different. On the other hand, I have to say I'm not that surprised because we haven't, like Russ said, we haven't looked at heart yet and considering that we can only cultivate a few percent of all the microbial diversity that exists on this planet as far as, [00:22:30] as far as we know it, it's not that surprising that you find these novel functions and there's these unique features and novel genetic codes because it's really, it's a highly under-explored area. Speaker 4: It is very rewarding. But if you look in the future, um, how much is still out of the sequence? Of course we're interested in that. So we looked at all the files show diversity that's known, that's out there based on this, um, biomarkers that Tony mentioned earlier and we just compared it to the genomes that we have sequenced so far. And we really want [00:23:00] to know, so if you want to cover let's say about 50% of all the fall diversity that's out there, how many achievements do we still have to sequence and the number of the estimate was we need to sequence at least 16,004 more genomes Speaker 5: and this is a moving target. So this is as we know, diversity of today it and every day we sample my environments, we sequence them deeper and everyday our diversity estimates increase. So what we've done with these 201 it's the tip of the iceberg but it's a start. Speaker 4: [00:23:30] Well Tanya and Chris, thanks for joining us. Thanks for having us. Thanks for having us. Yeah. Speaker 6: [inaudible] that's what shows are archived on iTunes to you. We've queued a simple link for you. The link is tiny, url.com/calex Speaker 7: spectrum Speaker 8: irregular feature of spectrum is a calendar [00:24:00] of some of the science and technology related events happening in the bay area over the next two weeks. Here's Brad swift and Renee Rao here today. Majority tomorrow. Expanding technological inclusion, technological inclusion is not an issue for some of us. It is an issue for all of us. Mitchell Kapore, co-chair of [inaudible] center for social impact and a partner at Kapore capital. We'll moderate a panel discussion among the following [00:24:30] presenters, Jennifer r Guayle, executive director of Latino to Kimberly Bryant, founder of Black Girls Code Connie Mack Keebler, a venture capitalist with the collaborative fund. Vivek Wadhwa academic researcher, writer and entrepreneur here today. Majority tomorrow is free and open to everyone on a first come first seated basis. This is happening on the UC Berkeley campus in Soutar de Di Hall [inaudible] [00:25:00] Auditorium Monday October 7th at 4:00 PM Speaker 7: the second installment of the six part public lecture series, not on the test. The pleasure and uses of mathematics will be held this October 9th Dr. Keith Devlin will deliver a lecture on underlying mathematics in video games. Dr Devlin will show how casual video games that provide representation of mathematics enabled children and adults to learn basic mathematics by playing in the same way people [00:25:30] learn music by learning to play the piano. Professor Devlin is a mathematician at Stanford, a Co founder and president of Inner Tube Games and the math guy of NPR. The lecture will be held on October 9th at 7:00 PM in the Berkeley City College Auditorium located at 2050 Center street in Berkeley. The event is free and open to the public. Speaker 8: The Leonardo arts science evening rendezvous or laser is a lecture series with rotating barrier venues. October 9th there will be a laser [00:26:00] at UC Berkeley. Presenters include Zan Gill, a former NASA scientists, Jennifer Parker of UC Santa Cruz, Cheryl Leonard, a composer, Wayne Vitali, founding member of gamelons Sakara [inaudible]. This is Wednesday, October 9th from 6:30 PM to 9:00 PM on the UC Berkeley campus in barrels hall room 100 Speaker 7: how can we prevent information technology [00:26:30] from destroying the middle class? Jaron Lanier, is it computer scientists, Kim Poser, visual artist and author. October 14th linear will present his ideas on the impact of information technology on his two most recent books are title. You are not a gadget and who owns the future. The seminar will be held in Sue Taja, Dai Hall, but not auditorium on the UC Berkeley campus. Monday, October 14th from 11:00 AM to noon [00:27:00] and that with some science news headlines. Here's the Renee, the intergovernmental panel on climate change released part of its assessment report. Five last Friday. The more than 200 lead authors on their report included Lawrence Berkeley National Labs, Michael Warner and William Collins who had a chapters on longterm climate change productions and climate models. The report reinforces previous conclusions that over the next century, the continents will warm [00:27:30] with more hot extremes and fewer cold extremes. Precipitation patterns around the world will also continue changing. One-Arm Collins noted that climate models since the last report in 2007 have improved significantly as both data collection and mechanistic knowledge have grown using these models. Scientists made several projections of different scenarios for the best, worst and middling cases of continued greenhouse emissions. Speaker 7: [00:28:00] Two recent accomplishments by commercial space programs are notable. Orbital Sciences launched their sickness spacecraft on September 18th a top the company's rocket and Tara's from wallops island, Virginia. On September 28th the Cygnus dock did the international space station for the first time, a space x rocket carrying and Canadian satellite has launched from the California coast in a demonstration flight of a new Falcon rocket. The next generation. Rocket boasts [00:28:30] upgraded engines designed to improve performance and carry heavier payloads. The rocket is carrying a satellite dead kiss IOP, a project of the Canadian Space Agency and other partners. Once in orbit it will track space weather. Speaker 2: Mm mm mm. Mm Huh. Speaker 7: The music [00:29:00] heard during the show was written and produced by Alex Simon. Yeah. Speaker 3: Thank you for listening to spectrum. If you have comments about the show, please send them to us via email. Address is [inaudible] dot [inaudible] dot com Speaker 9: [inaudible]. See acast.com/privacy for privacy and opt-out information.

Welcome to the launch of Women Who Innovate!  Our inaugural guest is the renowned Vivek Wadhwa, who has been relentless in the pursuit of getting more women involved in innovation.  The purpose of this radio show is to provide a platform where the voices of women innovators can be heard.  I could not be more honored that Vivek is opening up a subject that I am passionate on – inspiring women to get out of their comfort zones and innovate.  A few things about Vivek – in 1999, was named a “leader of tomorrow” by Forbes magazine; in 2012 was named one of six 2012 Outstanding American by Choice” recipients and was recognized by Foreign Policy magazine as a Top 100 Global Thinker.  In 2013, was named to Time magazine’s list of the Top 40 Most Influential Minds in Tech.  Join us as Vivek shares with us his groundbreaking crowdsourced campaign on gathering innovation stories from women!  

Dale Stephens was one of the original 24 recipients of the Thiel Fellowship. He is also the Founder of UnCollege. He recently came out with the book,"HACKING YOUR EDUCATION: Ditch the Lectures, Save Tens of Thousands, and Learn More Than Your Peers Ever Will."In this unique interview, Jason and Dale talk about some things high schoolers should assess before jumping into the college application process. Both see major problems the traditional college system. Young entrepreneurs sometimes struggle... not because of talent, but because older folk think they're too immature. Dale shares his tips for young'ns to be taken seriously.Dale believes an online portfolio can be even more impressive than a resume. He tells us how one can build a community of friends, mentors and a network of movers and shakers. Dale Stephens brings a unique perspective on the future of education. He is a sought-after education expert appearing on major news networks including CNN, ABC, NPR, CBS, Fox, and TechCrunch. His work has been covered by the New York Times and New York Magazine to Fast Company and Forbes. He has spoken around the world at high-profile events, from debating Vivek Wadhwa onstage at TED 2012 to lecturing at the New York Times to speaking to C-level executives at NBC Universal. At 21, Dale leads UnCollege.org because we're paying too much for college and learning too little. Penguin published his first book, Hacking Your Education, inApril 2013. In May 2011 Stephens was selected out of hundreds of individuals around the world as a Thiel Fellow, a program recognizing the top twenty-four entrepreneurs around the world under the age of twenty. In addition to leading UnCollege, Stephens advises education and technology companies. Visis Dale Stephens' official website at www.dalejstephens.com/. You can also view his company at www.uncollege.org/.

As late as the mid-twentieth century science and technology were celebrated as instruments of progress, but by the early twenty-first century they were viewed increasingly as threats to life on Earth. Vivek Wadhwa, Washington Post and Bloomberg Businessweek columnist, and Ahmed Zewail, winner of the 1999 Nobel Prize in Chemistry, discuss how science and technology may be managed to advance humanity. Series: "Ethics, Religion and Public Life: Walter H. Capps Center Series" [Science] [Show ID: 24776]

As late as the mid-twentieth century science and technology were celebrated as instruments of progress, but by the early twenty-first century they were viewed increasingly as threats to life on Earth. Vivek Wadhwa, Washington Post and Bloomberg Businessweek columnist, and Ahmed Zewail, winner of the 1999 Nobel Prize in Chemistry, discuss how science and technology may be managed to advance humanity. Series: "Ethics, Religion and Public Life: Walter H. Capps Center Series" [Science] [Show ID: 24776]

As late as the mid-twentieth century science and technology were celebrated as instruments of progress, but by the early twenty-first century they were viewed increasingly as threats to life on Earth. Vivek Wadhwa, Washington Post and Bloomberg Businessweek columnist, and Ahmed Zewail, winner of the 1999 Nobel Prize in Chemistry, discuss how science and technology may be managed to advance humanity. Series: "Ethics, Religion and Public Life: Walter H. Capps Center Series" [Science] [Show ID: 24776]

In 2005 immigrant entrepreneurs launched 52% of all startups in Silicon Valley. But today the number has dropped to 44% and America is not only losing the opportunity to create new jobs but also losing its competitive edge argues Vivek Wadhwa in his book The Immigrant Exodus: Why America Is Losing the Global Race to Capture Entrepreneurial Talent. In the 1980s skilled immigrants could get green cards in as little as 18 months but today it can take as long as 17 years. Failure to fix this problem says Wadhwa in an interview is killing American innovation. (Video with transcript) See acast.com/privacy for privacy and opt-out information.

Why do so few women work in tech, despite our love of consumer technology? Gina Trapani, Vivek Wadhwa and Adda Birnir weigh in. See acast.com/privacy for privacy and opt-out information.

Last week I interviewed Vivek Wadhwa on Singularity 1 on 1. I met Vivek last summer at Singularity University where he is the VP of academics and innovation. Vivek is one of those multi-talented and very outspoken people who are never afraid to take the risk and say what they think. He is also a […]

Vivek Wadhwa is a Visiting Scholar, School of Information, UC-Berkeley; Director of Research, Center for Entrepreneurship and Research Commercialization, and Exec in Residence, Pratt School of Engineering, Duke University; Senior Research Associate, Labor and Worklife Program, Harvard Law School; Distinguished Visiting Scholar, Halle Institute of Global Learning, Emory University; and faculty member and advisor at Singularity University. He helps students prepare for the real world; lectures in class; and leads groundbreaking research projects. He is also an advisor to several startup companies, a columnist for The Washington Post and Bloomberg BusinessWeek, and writes occasionally for several international publications. Prior to joining academia in 2005, Wadhwa founded two software companies. During our conversation, Vivek the reason why there is a lack of Blacks in position of power in the tech industry, what Blacks need to do to crack Silicon Valley, the pushback that he has received from a number of people for his views, African American feedback to his views and that there is hope for Black to make it and how to succeed in Silicon Valley. Click on the following link to read Vivek's article "We need a black Mark Zuckerburg": http://wadhwa.com/2011/06/24/washington-post-we-need-a-black-mark-zuckerberg/ You can connect with Vivek via: http://wadhwa.com/ (Website) @wadhwa Wadhwa@duke.edu (email)

Vivek Wadhwa of UC Berkeley and Rich Skrenta, CEO of Blekko, a search engine designed to tackle spam, look at Google’s changing algorithm. Then: How social media is altering the way patients tackle disease and the way lawyers select juries.

Vivek Wadhwa on the role of TiE, with Rohit Chandra

Gary discusses the need for education, company sponsored education, and talks about entrepreneur education at Stanford, Vivek Wadhwa writing at TechCrunch on why America needs to invest in its workforce, a Robert Scoble video interview and finally refers to a Seth Godin blog with a video on what a teacher makes.

John Hope Franklin Center

A look at how immigration policy and patterns affect American business and the economy. Our speakers will discuss trends and offer thoughts on issues such as American competitiveness, the H1-B visa cap, outsourcing, the US-India-China business relationship and much more. Speakers: VINOD DHAM, founder of NEA-IndoUS Ventures and "the father of the Pentium processor"; and VIVEK WADHWA, a fellow at Harvard Law School and exec in residence at Duke Univ who's doing research on these issues.

This week we talk with Vivek Wadhwa, columnist for Business Week, Wertheim Fellow at the Harvard Law School and executive in residence at Duke University. Wadhwa will be discussing his recent article (The Science Education Myth) regarding science education in the United States. Quotes from the show: “It's commonly accepted that the U.S. is falling behind other countries because our children score badly on math and science test scores and so on. The National Academies has sited this data; the President alluded to it in his last State of the Union address in 2006, the U.S. Department of Education talks about it. Everyone seems to accept the fact that the U.S. is falling behind and there is something wrong with our education system...I had a suspicion this was wrong.? “We actually added up the numbers, and we found that the U.S. graduates a comparable number [engineers] to India, and the Chinese numbers are bogus. Basically they're published from the Chinese government and you can't challenge it; the Chinese numbers are high, but there are huge quality issues in both India and China.? “The U.S is in pretty good shape. Maybe there are a few small nations, like Latvia and Singapore that come in first place, but those are small countries and you can't compare a population of the size and the diversity of the U.S.A. with countries like Singapore, which are small and have a different system than we do.? “Almost every indicator that they looked at showed the same trend – that the U.S.A. was improving; it wasn't getting worse. And that no other country in the world was improving like the U.S.A. was.? “If you look at what spurred the sciences, it was Sputnik. The Manhattan project employed 100-200,000 engineers. Whenever there's been a crisis, the U.S. has responded to it by putting together national programs. The fact is that global warming is a critical national program. The fact that we're consuming oil and burning up the world is a critical threat to the U.S.A. There are so many diseases that need to be eradicated. Instead of spending another 100 billion dollars on Iraq, why don't we take 100 billion dollars and spend it on doing constructive research on eliminating diseases, of improving the world.? “I think the U.S. really has to get its act together. We have to create the demand for engineers and scientists, and create the excitement, and create the motivation for our students to move into these fields. Just graduating more doesn't solve any it just creates unemployment. But create a demand, create an excitement, is how you solve one of the problems.? Links: The Science Education Myth, by Vivek Wadhwa from Business Week Assessing the Evidence on Science and Engineering Education, Quality, and Workforce Demand, by B. Lindsay Lowell, Harold Salzman; report by the Urban Institute Rising above the Gathering Storm; report from the National Academies Press State of the Union Address by the President; January 31, 2006 U.S. Must act to Close Dentist Gap from Pure Pedantry A Silver Lining to Our Science Struggles by David Epstein, from SEED Magazine (article as podcast) In Science Classrooms, A Blast of Fresh O2 by Natalie Angier from the New York Times Math and Science Education from NPR's Science Friday; November 9th, 2007