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5 episodes with cerebrolysin
2 episodes with cerebrolysin
3 episodes with cerebrolysin
2 episodes with cerebrolysin
2 episodes with cerebrolysin
2 episodes with cerebrolysin
2 episodes with cerebrolysin
3 episodes with cerebrolysin
2 episodes with cerebrolysin
Unlock the transformative potential of peptides in this in-depth, science-driven lecture designed for medical professionals and health enthusiasts alike. This episode explores the therapeutic applications of peptides for brain health (Cerebrolysin, Selank, Semax), gastrointestinal and musculoskeletal repair (BPC-157, CJC-1295/Ipamorelin, TB500), bone health (MK-677, CJC-1295/Ipamorelin), and immune modulation (Thymosin Alpha-1). Backed by clinical and preclinical data, we dive into how these powerful amino acid chains enhance neurogenesis, tissue regeneration, bone density, and immune function. Perfect for those seeking cutting-edge insights into peptide therapy, regenerative medicine, and longevity optimization. Learn more about peptides in the episodes below: Orally Available Peptides - the FUTURE of peptide therapy with Kyal Van Der Leest Longevity Supplements, peptides and more with Dr Elizabeth Yurth Longevity with Oral Peptides: The Future of Healthy Aging with Michael Antonelli Peptides and Epigenetic Age Testing - Optimising your Future Health Now By Ryan Smith Peptides for Optimal Health: What You Need to Know with Dr Yurth Turn Back The Hands Of Time Using Bioregulator Peptides By Dr Bill Lawrence Bioregulator Peptides and longevity with Phil Micans Msc Shop High-Quality Peptides with Exclusive Discounts: Lvlup Health Peptides: Get 10% of your order today Biolongevity Labs: Save 10% at Biolongevity Labs Orally available peptides through our formulation Rejuvenate Pro: Aevum Labs, Flagship product also contains powerful peptides including naturally occurring bioactive peptides derived from colostrum. Key Peptide Components in Re:juvenate Pro
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Today, we're talking about a hot topic in the world of fitness and wellness: peptide stacking. Whether you're looking to build lean muscle, burn fat, enhance recovery, or boost cognitive function, peptide stacking could be a game-changer. But, just like anything, it's important to know the ins and outs of how it works and how to “stack” safely. What is Peptide Stacking? So, what is peptide stacking, and how can it benefit you? Let's break it down. At its core, peptide stacking refers to the practice of combining different peptides to maximize their individual effects and synergize their benefits. Keep in mind, there's no "magic" stack that works for everyone. Each stack is chosen based on the person's symptoms or what effect they want to achieve. The concept is pretty similar to stacking supplements or combining different types of training programs. When done right, stacking peptides can enhance muscle growth, accelerate fat loss, improve recovery, and boost cognitive function. But, not all peptides play well together, and some shouldn't be mixed. We'll dive into those potential issues in a bit. First, let's talk about the benefits of stacking. What Are the Potential Benefits of Stacking Peptides? So, what are the benefits of stacking peptides? First off, synergistic effects – when peptides work together, they can boost each other's impact, helping with muscle growth and speeding up recovery time. Then, there's the ability to tackle multiple goals at once. Whether you're focusing on fat loss, building muscle, or even improving brain function, stacking peptides lets you work on a few things at the same time. Lastly, customization is a big perk. You can adjust your stack based on your specific needs and make changes as your body adapts, so you're always on track to reach your goals. What Are Some Risks of Peptide Stacking? Some peptides shouldn't be mixed, as they can cause negative effects or reduce each other's effectiveness. For example, combining GHRP-6 (stimulates growth hormone) with somatostatin (inhibits growth hormone) would be counterproductive. Also, stacking too many peptides affecting the same pathways could overwhelm your system, leading to side effects like insulin resistance or excessive GH levels. Popular Peptide Stacks While there are countless peptide therapies and hundreds of possible stack combinations that can offer great benefits, I can't cover them all, but let's dive into some of the most common and effective peptide stacks for different goals. Building Lean Muscle Mass: If you're aiming to pack on lean muscle, a great stack to try is CJC-1295 with DAC + Ipamorelin + BPC-157. This combo helps release growth hormone and boosts muscle recovery. But if you really want to take it up a notch, adding MK-677 to the mix is a game-changer. MK-677 is a growth hormone secretagogue that mimics ghrelin, the hunger hormone, which not only increases growth hormone levels but also helps with muscle growth and fat loss. One of the best things about MK-677 is its ability to stimulate appetite, which is perfect for anyone who's training hard but struggles to eat enough calories and protein. If you have a naturally low appetite, MK-677 can make it much easier to consume the fuel you need for muscle growth and recovery. Fat Loss: For fat loss, MOTS-c + Semaglutide is a great stack. MOTS-c helps with fat metabolism, and Semaglutide helps control appetite, making it easier to stick to a calorie-restricted diet for sustainable fat loss. Another effective stack is CJC-1295 + Ipamorelin + Semaglutide. The CJC-1295 and Ipamorelin combo promotes growth hormone release, which supports fat burning and muscle preservation, while Semaglutide helps control hunger, making fat loss a little easier. If belly fat is a particular concern, consider Tesamorelin + Semaglutide. Tesamorelin boosts growth hormone, especially around the abdominal area, reducing visceral fat (that deep belly fat). This stack is great for targeting stubborn belly fat while still promoting overall fat loss. Recovery & Healing: When it comes to recovery, BPC-157 + TB-500 is an incredible combo. BPC-157 is known as the king of healing peptides. It helps speed up tissue repair, reduce inflammation, and regenerate muscles, ligaments, and tendons. TB-500 works alongside it to promote wound healing and cell regeneration, further reducing inflammation and speeding up recovery from injuries. Together, these peptides help you heal faster and get back to your workouts with less downtime. Cognitive Function: If you're looking to boost your brainpower, Cerebrolysin + Semax is a solid stack. Cerebrolysin enhances brain function by promoting neuroplasticity and stimulating growth factors to protect and regenerate brain cells, improving memory and mental clarity. On the other hand, Semax enhances memory, reduces stress, and improves focus by increasing BDNF (brain-derived neurotrophic factor). A great approach is to use Semax daily for consistent cognitive benefits and Cerebrolysin on alternate days for neuroprotection and brain regeneration. This way, you're supporting your brain health and mental performance consistently. Peptide stacking can be an incredibly powerful tool when used correctly, helping you achieve your fitness, recovery, and cognitive goals faster and more efficiently. However, it's vital to understand the potential risks and make sure you're combining peptides that complement each other rather than counteracting each other's effects. Always be mindful of the peptides you're stacking. Thanks for listening to The Peptide Podcast. If you found this episode helpful, be sure to subscribe and leave a review. And as always, have a happy, healthy week. We're huge advocates of elevating your health game with nutrition, supplements, and vitamins. Whether it's a daily boost or targeted support, we trust and use Momentous products to supercharge our wellness journey. Momentous only uses the highest-quality ingredients, and every single product is rigorously tested by independent third parties to ensure their products deliver on their promise to bring you the best supplements on the market.
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Watch Here : https://www.youtube.com/watch?v=jycOQ_t6yZ0 Website: https://vigoroussteve.com/ Consultations: https://vigoroussteve.com/consultations/ eBooks: https://vigoroussteve.com/shop/ YouTube Channel: http://www.youtube.com/user/VigorousSteve/ Workout Clips Channel: https://www.youtube.com/channel/UCWi2zZJwmQ6Mqg92FW2JbiA Instagram: https://instagram.com/vigoroussteve/ TikTok: https://www.tiktok.com/@vigoroussteve Reddit: https://www.reddit.com/r/VigorousSteve/ PodBean: https://vigoroussteve.podbean.com/ Spotify: https://open.spotify.com/show/2wR0XWY00qLq9K7tlvJ000 Patreon: https://www.patreon.com/vigoroussteve
In this episode of the Unreasonable Health Podcast, Regan Archibald dives into cutting-edge strategies for cognitive enhancement, focusing on neuroinflammation, gut health, and brain optimization. He explores the role of Peptides like C-Max, Cerebrolysin, and LL-37, as well as innovative treatments such as umbilical cord plasma and intranasal NAD. Regan also discusses the impact of mold exposure, heavy metals, and gut dysbiosis on brain function while sharing actionable tips for improving memory, focus, and mental clarity. Tune in to discover powerful tools to upgrade your brain health and performance!
In this episode of Unreasonable Health, Regan Archibald explores Part 1 of the power of nootropics and peptides in optimizing brain health and cognitive function. Fresh from the Da Vinci 50 conference, he shares groundbreaking insights into how stem cells can be re-engineered to regenerate the brain and other organs. Regan dives deep into the benefits of peptides like Semax, Cerebrolysin, and Selank, explaining their roles in enhancing focus, memory, and neuroplasticity. He also discusses the importance of brain-derived neurotrophic factor (BDNF) and how peptides, combined with choline and growth hormone pathways, can maximize cognitive function. The episode emphasizes the role of gratitude in brain health, the impact of stress on neuroanatomy, and the promising future of brain rejuvenation treatments. Attendees are encouraged to try peptides, engage in brain-boosting activities, and embrace an ageless future mindset. Want to take your brain health to the next level? Get labs done, attend a retreat, and learn more about our programs and services here!
In this episode, Dr. Craig Koniver, M.D., a board-certified physician trained at Brown University and Thomas Jefferson University, discusses the therapeutic application of peptides and hormones for enhancing physical and mental health and performance. We explore GLP-1 analogs for weight loss, BPC-157 for wound healing and reducing inflammation, as well as peptides that increase growth hormone, improve REM sleep, and enhance cognitive function. We also cover testosterone therapy, NAD, NMN, and NR supplementation, methylene blue for mitochondrial health, stem cell therapies, and supplements such as CoEnzyme Q10 and methylated B vitamins. Additionally, we discuss effective dosages, sourcing, safety considerations, and the importance of working with knowledgeable physicians. Whether you're currently using peptides or exogenous hormones, or simply curious about their potential benefits and risks, this episode provides the scientific rationale behind how peptides function, their potential to enhance mental and physical health, and how they can optimize performance. Access the full show notes for this episode at hubermanlab.com. Thank you to our sponsors AG1: https://drinkag1.com/huberman Joovv: https://joovv.com/huberman BetterHelp: https://betterhelp.com/huberman Function: https://functionhealth.com/huberman Eight Sleep: https://eightsleep.com/huberman Timestamps 00:00:00 Dr. Craig Koniver 00:04:52 Sponsors: Joovv & BetterHelp 00:07:40 What is a Peptide? 00:09:37 GLP-1 Agonists, Semaglutide Weight Loss, Brain Health 00:15:49 GLP-1 Microdoses, Muscle Loss; Inflammation 00:18:43 BPC-157, Inflammation 00:23:27 BPC-157, Injection & Oral Forms; Injury Repair 00:28:43 Sourcing, Anabolic Steroids, Testosterone 00:34:48 Black & Gray Market, Compounding Pharmacies, Purity 00:38:20 Sponsor: AG1 00:39:51 Partnering with a Physician, LPS 00:43:00 BPC-157, Pentadeca Arginate (PDA); Side Effects & Doses 00:46:35 Ipamorelin, GHRP-6, Sleep, Appetite; Tool: Sleep & Growth Hormone 00:54:17 Tesamorelin, Sermorelin, CJC-1295; Stacking Peptides 00:58:45 Sponsor: Function & Eight Sleep 01:01:54 Coenzyme Q10 (CoQ10), Mitochondrial Health 01:05:16 Prescriptions, Physicians & Trust 01:14:09 Agency in Your Health 01:17:13 MK-677, Appetite 01:19:32 Hexarelin; Growth Hormone Secretagogues Dosing 01:21:10 Methylated B Vitamins, Homocysteine 01:24:47 Peptides for Sleep, Pinealon, Epitalon 01:31:03 Glycine, Liver Detoxification; Dosage 01:37:19 GLP-1, Compounding Pharmacies 01:39:03 Stem Cell Therapy, PRP 01:41:18 Thymosin Alpha-1, Cerebrolysin & Brain Health 01:44:17 Peptides for Cognitive Function, Methylene Blue, Doses 01:50:20 Covid, NAD Infusion, NMN & NR Supplements 01:57:13 Nutritional Deficiencies; NAD Dose & Regimen, NMN & NR 02:07:53 PT-141, Vyleesi, Libido; Nausea 02:10:57 FDA Approval & Removal, Pharmaceutical Companies 02:20:17 Positivity, Mindset & Health 02:26:23 Zero-Cost Support, YouTube, Spotify & Apple Follow & Reviews, Sponsors, YouTube Feedback, Protocols Book, Social Media, Neural Network Newsletter Disclaimer & Disclosures
Jay Campbell is a returning guest here to discuss peptides in great detail, including reconstitution! Tune into and learn how to beat jet lag, improve your sleep, heal from v@x injuries, improve cognition, and much more! Join Jay live in person for his Fully Optimized Health Summit September 27-29! Hyperlinked show notes at: www.ashleydeeley.com/w2w/jaycampbellpeptides1 Episode brought to you by: Alive Waters (Code: ASHLEY) Episode brought to you by: Thyroid Fixxr (Code: WELCOMEWELLNESS) Episode brought to you by: My Pure Water (CODE: Ashley5) 4:08: The best part about peptides 5:09: What do peptides do? 6:22: Cerebrolysin peptide for neurodegenerative disease, early onset of dementia, Alzheimer's, Lou Gehrig's, Jacob Creutzfeldt (CJD) 7:13: Mechanisms for peptide delivery 8:34: Jay's favorite peptides: Immunity: Thymosin Alpha 1 Peptide Immunity: BPC 157 (Body Protective Compound) Repair & Healing: TB-500 (Jay carries vial of BPC-157 & TB-500 everywhere he goes) Fat Loss for Men: Tesamorelin Fat Loss for Women: Ipamorelin Darken skin & up level consciousness: Melanotan 1 11:28: Joe Rogan says he didn't need shoulder surgery after taking BPC-157 13:04: Melanotan 1 enhances your ability to absorb the sun's rays 13:40: Regan Archibald (one of the world's leading peptide and anti aging docs) 14:32: Reputable source for buying peptides: Jay's Limitless website Peptide Sciences website Compounding pharmacies 17:52: Afraid of injecting? (Watch YouTube video here!) 19:45: The best place to inject for an injury is the injury site 20:04: How to store peptides (if unconstituted, they are shelf stable and require no refrigeration) 20:37: Once reconstituted, they require refrigeration 20:50: How to reconstitute peptides (the number one question!!) 21:30: Peptide Reconstitution: Dosing, Mixing and Storage Information PLUS the Peptide Calculator 25:29: Can we overdose on peptides? 26:22: CJC-1295 peptide (can create a niacin flush) 26:38: Melanotan 2 can cause nausea (Jay's airplane story) 29:09: Number one thing about peptides: you must cycle them as they cause antibody buildup 30:05: How long do peptides take to work? 30:41: How do you get peptides through TSA? 32:26: Tips for beating jet lag DSIP peptide High dose melatonin 34:08: Peptides for sleep? 36:16: Why peptides won't work for some people... 40:00: You're going to see better improvement if you're already hormonally optimized when you use peptides 40:24: Trouble sleeping? You must be hormonally optimized first! 40:30? Belly fat? Get your hormones tested first! 41:50: Alternative ways of healing (from the V.@.X) Nattokinase N-Acetylcysteine Methylene Blue Nicotine gum (1 mg) Nic Nac Jay emailed me his 'Vax Injury Peptide Stack' PDF so please email me if you'd like a copy (hello@ashleydeeley.com) LL-37 peptide VIP (Vasoactive Intestinal Peptide) Where to find Jay: Website Instagram Amazon Where to find Ashley Deeley: Website Instagram Facebook YouTube hello@ashleydeeley.com
Download The Peptide Cheat Sheet: https://peptidecheatsheet.carrd.co/
In this comprehensive video, we delve into various advanced therapies and supplements that can significantly enhance brain health and support recovery from brain injuries. Join us as we explore the science behind exogenous ketones, Dihexa, Cerebrolysin, Selank, Semax, plasmalogens, hyperbaric oxygen therapy (HBOT), and photobiomodulation. Learn how these innovative treatments work and their potential benefits for cognitive function and brain health. Topics Covered: Exogenous Ketones: Alternative energy source for the brain, anti-inflammatory effects, neuroprotection, and promotion of brain plasticity. Dihexa: Neurogenic and neurotrophic properties, enhancement of cognitive function, and promotion of synaptogenesis and neurogenesis. Cerebrolysin: Neurotrophic factors, neuroprotection, neuroplasticity, and cognitive function improvement. Selank and Semax: Anxiolytic and cognitive-enhancing effects, neuroprotection, and influence on neurotransmitter systems. Plasmalogens: Phospholipids, membrane integrity, oxidative stress reduction, and support for neurogenesis. Hyperbaric Oxygen Therapy (HBOT): Enhanced oxygen delivery, reduced inflammation, neuroprotection, and promotion of neurogenesis and angiogenesis. Photobiomodulation: Red and near-infrared light therapy, mitochondrial function enhancement, and neuroprotection. Research References: Cerebrolysin: - Study on Cerebrolysin and Neuroprotection in Stroke Journal of Neurology - Research on Cerebrolysin's impact on cognitive function and neuroplasticity. Dihexa: - Dihexa's Effects on Cognitive Enhancement and Neurogenesis Neuroscience Letters - Study on Dihexa and its binding to HGF receptors, promoting synaptogenesis. Selank and Semax: - Selank: Anxiolytic and Cognitive-Enhancing Properties - Semax: Neuroprotective and Cognitive-Enhancing Effects Journal of Molecular Neuroscience - Research on Selank and Semax's mechanisms and benefits. Hyperbaric Oxygen Therapy (HBOT): - HBOT for Stroke Recovery Journal of Neurotrauma - Studies on the effectiveness of HBOT in brain injury recovery and neuroprotection. Key Points: Exogenous ketones provide an alternative energy source and possess anti-inflammatory and neuroprotective properties. Dihexa enhances cognitive function by promoting neurogenesis and synaptogenesis. Cerebrolysin supports neuronal survival, neuroplasticity, and cognitive function. Selank and Semax offer anxiolytic and cognitive-enhancing benefits, influencing neurotransmitter systems and providing neuroprotection. Plasmalogens support membrane integrity, reduce oxidative stress, and promote neurogenesis. HBOT enhances oxygen delivery, reduces inflammation, promotes neuroprotection, and supports neurogenesis and angiogenesis. Photobiomodulation uses red and near-infrared light to enhance mitochondrial function and provide neuroprotection. Personalised Health Optimisation Consulting with Lisa Tamati Lisa offers solution focused coaching sessions to help you find the right answers to your challenges. Topics Lisa can help with: Lisa is a Genetics Practitioner, Health Optimisation Coach, High Performance and Mindset Coach. She is a qualified Ph360 Epigenetics coach and a clinician with The DNA Company and has done years of research into brain rehabilitation, neurodegenerative diseases and biohacking. She has extensive knowledge on such therapies as hyperbaric oxygen, intravenous vitamin C, sports performance, functional genomics, Thyroid, Hormones, Cancer and much more. She can assist with all functional medicine testing. 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You don't want to miss out on all the great content on our Lisa's youtube channel. Youtube Order Lisa's Books Lisa has published 5 books: Running Hot, Running to Extremes, Relentless, What your oncologist isn't telling you and her latest "Thriving on the Edge" Check them all out at https://shop.lisatamati.com/collections/books Perfect Amino Supplement by Dr David Minkoff Introducing PerfectAmino PerfectAmino is an amino acid supplement that is 99% utilized by the body to make protein. PerfectAmino is 3-6x the protein of other sources with almost no calories. 100% vegan and non-GMO. The coated PerfectAmino tablets are a slightly different shape and have a natural, non-GMO, certified organic vegan coating on them so they will glide down your throat easily. Fully absorbed within 20-30 minutes! No other form of protein comes close to PerfectAminos Listen to the episode with Dr Minkoff here: Use code "tamati" at checkout to get a 10% discount on any of their devices. 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[This article was originally published on Dan Elton's blog, More is Different.]Cerebrolysin is an unregulated medical product made from enzymatically digested pig brain tissue. Hundreds of scientific papers claim that it boosts BDNF, stimulates neurogenesis, and can help treat numerous neural diseases. It is widely used by doctors around the world, especially in Russia and China.A recent video of Bryan Johnson injecting Cerebrolysin has over a million views on X and 570,000 views on YouTube. The drug, which is advertised as a “peptide combination”, can be purchased easily online and appears to be growing in popularity among biohackers, rationalists, and transhumanists. The subreddit r/Cerebrolysin has 3,100 members. TL;DRUnfortunately, our investigation indicates that the benefits attributed to Cerebrolysin are biologically implausible and unlikely to be real. Here's what we found: Cerebrolysin has been used clinically since the 1950s, and has escaped regulatory oversight due to some [...] ---Outline:(00:56) TL;DR(02:50) Introduction(04:03) The long history of Cerebrolysin(07:31) Cerebrolysin.com is full of scientific errors(13:43) The evidence base for Cerebrolysin contains conflicts of interest and a statistically improbable rate of success(17:52) So WTH is Cerebrolysin?(24:51) We only found one study giving evidence of neurotrophic factors in Cerebrolysin, and it's kinda sus(26:45) HPLC-mass spectroscopy of Cerebrolysin fails to show any neurotrophic peptides(28:38) Storage instructions are incongruent with peptides and there is no immune response(30:57) The putative active ingredients are unlikely to cross the blood-brain barrier(36:34) Concluding metascience thoughtsThe original text contained 6 footnotes which were omitted from this narration. The original text contained 12 images which were described by AI. --- First published: August 6th, 2024 Source: https://www.lesswrong.com/posts/ZznBxPdZEB6ETeZvS/wth-is-cerebrolysin-actually --- Narrated by TYPE III AUDIO. ---Images from the article:
Welcome to The Nonlinear Library, where we use Text-to-Speech software to convert the best writing from the Rationalist and EA communities into audio. This is: WTH is Cerebrolysin, actually?, published by gsfitzgerald on August 6, 2024 on LessWrong. [This article was originally published on Dan Elton's blog, More is Different.] Cerebrolysin is an unregulated medical product made from enzymatically digested pig brain tissue. Hundreds of scientific papers claim that it boosts BDNF, stimulates neurogenesis, and can help treat numerous neural diseases. It is widely used by doctors around the world, especially in Russia and China. A recent video of Bryan Johnson injecting Cerebrolysin has over a million views on X and 570,000 views on YouTube. The drug, which is advertised as a "peptide combination", can be purchased easily online and appears to be growing in popularity among biohackers, rationalists, and transhumanists. The subreddit r/Cerebrolysin has 3,100 members. TL;DR Unfortunately, our investigation indicates that the benefits attributed to Cerebrolysin are biologically implausible and unlikely to be real. Here's what we found: Cerebrolysin has been used clinically since the 1950s, and has escaped regulatory oversight due to some combination of being a "natural product" and being grandfathered in. Basic information that would be required for any FDA approved drug is missing, including information on the drug's synthesis, composition, and pharmacokinetics. Ever Pharma's claim that it contains neurotrophic peptides in therapeutic quantities is likely false. HPLC and other evidence show Cerebrolysin is composed of amino acids, phosphates, and salt, along with some random protein fragments. Ever Pharma's marketing materials for Cerebrolysin contain numerous scientific errors. Many scientific papers on Cerebrolysin appear to have ties to its manufacturer, Ever Pharma, and sometimes those ties are not reported. Ever Pharma's explanation of how the putative peptides in Cerebrolyin cross the blood-brain barrier does not make sense and flies in the face of scientific research which shows that most peptides do not cross the blood-brain barrier (including neurotrophic peptides like BDNF, CDNF, and GDNF). Since neurotrophic factors are the proposed mechanism for Cerebrolysin's action, it is reasonable to doubt claims of Cerebrolysin's efficacy. Most scientific research is false. It may have a mild therapeutic effect in some contexts, but the research on this is shaky. It is likely safe to inject in small quantities, but is almost certainly a waste of money for anyone looking to improve their cognitive function. Introduction One of us (Dan) was recently exposed to Cerebrolysin at the Manifest conference in Berkeley, where a speaker spoke very highly about it and even passed around ampoules of it for the audience to inspect. Dan then searched for Cerebrolysin on X and found a video by Bryan Johnson from May 23 that shows him injecting Cerebrolysin. Johnson describes it as a "new longevity therapy" that "fosters neuronal growth and repair which may improve memory." Dan sent the video to Greg Fitzgerald, who is a 6th year neuroscience Ph.D. student at SUNY Albany. Greg is well-versed on the use of neurotrophic peptides for treating CNS disorders and was immediately skeptical and surprised he had not heard of it before. After Greg researched it, he felt a professional responsibility to write up his findings. He sent his writeup to Dan, who then extensively edited and expanded it. Our critique covers three major topics: (1) sketchy marketing practices, (2) shoddy evidence base, and (3) implausible biological claims. But first, it's interesting to understand the history of this strange substance. The long history of Cerebrolysin To our knowledge, the "secret history" of Cerebrolysin has not been illuminated anywhere to date. Cerebrolysin was invented by the Austrian psychiatrist and neurologist Gerhart Harrer (1917 - 2011), who started usin...
Link to original articleWelcome to The Nonlinear Library, where we use Text-to-Speech software to convert the best writing from the Rationalist and EA communities into audio. This is: WTH is Cerebrolysin, actually?, published by gsfitzgerald on August 6, 2024 on LessWrong. [This article was originally published on Dan Elton's blog, More is Different.] Cerebrolysin is an unregulated medical product made from enzymatically digested pig brain tissue. Hundreds of scientific papers claim that it boosts BDNF, stimulates neurogenesis, and can help treat numerous neural diseases. It is widely used by doctors around the world, especially in Russia and China. A recent video of Bryan Johnson injecting Cerebrolysin has over a million views on X and 570,000 views on YouTube. The drug, which is advertised as a "peptide combination", can be purchased easily online and appears to be growing in popularity among biohackers, rationalists, and transhumanists. The subreddit r/Cerebrolysin has 3,100 members. TL;DR Unfortunately, our investigation indicates that the benefits attributed to Cerebrolysin are biologically implausible and unlikely to be real. Here's what we found: Cerebrolysin has been used clinically since the 1950s, and has escaped regulatory oversight due to some combination of being a "natural product" and being grandfathered in. Basic information that would be required for any FDA approved drug is missing, including information on the drug's synthesis, composition, and pharmacokinetics. Ever Pharma's claim that it contains neurotrophic peptides in therapeutic quantities is likely false. HPLC and other evidence show Cerebrolysin is composed of amino acids, phosphates, and salt, along with some random protein fragments. Ever Pharma's marketing materials for Cerebrolysin contain numerous scientific errors. Many scientific papers on Cerebrolysin appear to have ties to its manufacturer, Ever Pharma, and sometimes those ties are not reported. Ever Pharma's explanation of how the putative peptides in Cerebrolyin cross the blood-brain barrier does not make sense and flies in the face of scientific research which shows that most peptides do not cross the blood-brain barrier (including neurotrophic peptides like BDNF, CDNF, and GDNF). Since neurotrophic factors are the proposed mechanism for Cerebrolysin's action, it is reasonable to doubt claims of Cerebrolysin's efficacy. Most scientific research is false. It may have a mild therapeutic effect in some contexts, but the research on this is shaky. It is likely safe to inject in small quantities, but is almost certainly a waste of money for anyone looking to improve their cognitive function. Introduction One of us (Dan) was recently exposed to Cerebrolysin at the Manifest conference in Berkeley, where a speaker spoke very highly about it and even passed around ampoules of it for the audience to inspect. Dan then searched for Cerebrolysin on X and found a video by Bryan Johnson from May 23 that shows him injecting Cerebrolysin. Johnson describes it as a "new longevity therapy" that "fosters neuronal growth and repair which may improve memory." Dan sent the video to Greg Fitzgerald, who is a 6th year neuroscience Ph.D. student at SUNY Albany. Greg is well-versed on the use of neurotrophic peptides for treating CNS disorders and was immediately skeptical and surprised he had not heard of it before. After Greg researched it, he felt a professional responsibility to write up his findings. He sent his writeup to Dan, who then extensively edited and expanded it. Our critique covers three major topics: (1) sketchy marketing practices, (2) shoddy evidence base, and (3) implausible biological claims. But first, it's interesting to understand the history of this strange substance. The long history of Cerebrolysin To our knowledge, the "secret history" of Cerebrolysin has not been illuminated anywhere to date. Cerebrolysin was invented by the Austrian psychiatrist and neurologist Gerhart Harrer (1917 - 2011), who started usin...
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Dr. Neil Paulvin can help you look and feel your best with peptides, nootropics, supplements, and biohacks such as red light therapy, methylene blue, and more. If you're looking to improve cognitive function as well as your skin, this episode is for you! This episode is brought to you by JOYLUX. Use code ASHLEY10 to save 10% 7:13: Peptides to make your hair grow 7:48: The 'Botox'-like peptide (most popular: BPC-157) 10:19: Psoriasis and eczema peptides 11:17: Peptides to heal the gut 12:43: Butyrate is superstar supplement (may help with weight loss) 13:35: Mast cell activation syndrome 14:50: Peptides for healing and recovery 17:49: HgH 21:50: Peptides to improve cognitive function 21:59: Cerebrolysin (best brain peptide) 22:37: Dihexa (brain peptide) 23:11: Prodome 24:29: Possible Neuropathy treatments: ARA290 peptide 25:57: MOTS-C helps boost energy, build bone, improve mitochondria function 30:00: Dr. Paulvin is one of the only doctor's treating relief from fluoroquinolone side effect reactions (Ciprofloxacin, Delafloxacin, Factive, Floxin, Gemifloxacin, Levaquin) 33:23: He used to get bad headaches, then treated himself with great success and his headaches stopped 40:16: The Vie Light (Code: DEELEY10) 40:30: Neuronic Red Light Therapy Helmet 40:52: Light Path LED 40:54: GembaRed 40:56: EMR-Tek Red Light Therapy (my favorite red light therapy device! Code: ASHLEY15) 43:23: Top recommended nootropics, including Centrifenoxine/Lucidril 43:34: Methylene blue (my fave brand, called Oxidal) (my other fave brand called TroScriptions) 46:01: Vagal neural stimulator Where to find Dr Paulvin: Website
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The human body has over 3,000 peptides that support different biochemical processes. Scientists have also discovered over 6,000 peptides in plants that are fit for human use. What are peptides, and why does your body need so many? Awais Spall, a functional medicine practitioner, joins the show today to discuss the top 10 peptides we all need and their health benefits. He also shares his experience of how peptides healed his shoulder injury after everything else failed. That experience led Awais to explore peptides, microbiome medicine, and Ayurvedic interventions. Today, he shares the best ways to use peptides to regulate the immune system and heal the gut. He also recommends specific peptides for bodybuilding, skin health, a speedy recovery after surgery or infection, ADHD, and brain functions. Where should you start with peptides? Tune in to find out. “You break the brain, you break the gut. You break the gut, you break the brain.” - Awais Spall Today's Episode Explores: - What are peptides? - What is Thymosin Alpha 1 (TA-1) used for? - What is KPV peptide, and what are its benefits? - How to use Thymosin Beta Four (TB-4) peptide - What is Cerebrolysin peptide used for? - How is Epitalon peptide used in the body? - The health benefits of Larazotide peptide - GHK-Cu peptide and its skincare benefits - BPC 157 peptide usage for muscle, tissue, and brain healing - What is Vasoactive Intestinal Peptide (VIP)? - How many peptides should you take at once? - The benefits of the LL37 and TA-1 combo - What does Vesugen peptide do to your body? - What is Selank peptide, and how is it used? - What does CJC Ipamorelin do? - How to improve your gut microbiome - How do antimicrobials optimize the microbiome? For more information visit www.myersdetox.com/AwaisSpall After listening to this episode, you might be wondering about heavy metals. You can take my quiz here for more info: heavymetalsquiz.com About Awais Spall: Awais Spall FDN-P is a functional medicine practitioner based in Venice, CA. His practice integrates functional medicine, regenerative medicine, and Ayurveda to optimize gut health. Before becoming a health practitioner, Awais worked as a formulation chemist. He eventually left the formulation world to launch Integrative Oasis, a microbiome-focused health practice that integrates peptides, bio-regulators, exosomes, ozone therapy, plant medicines, and polyvagal interventions. Website - http://www.integrativeoasis.com Instagram - https://www.instagram.com/integrativeoasis/ The Myers Detox Podcast was created and hosted by Dr. Wendy Myers. This podcast is for information purposes only. Statements and views expressed on this podcast are not medical advice. This podcast, including Wendy Myers and the producers, disclaims responsibility for any possible adverse effects from using the information contained herein. Opinions of guests are their own, and this podcast does not endorse or accept responsibility for statements made by guests. This podcast does not make any representations or warranties about guests' qualifications or credibility. Individuals on this podcast may have a direct or indirect financial interest in products or services referred to herein. If you think you have a medical problem, consult a licensed physician.
Dr. Kirk Parsley is certified in Hyperbaric Medicine, Anti-Aging Medicine, Hormone Replacement Therapy, and is currently pursuing national certification in Psychedelic Medicine Therapies. He dedicates a significant portion of his time to advising non-profit organizations that support the SEAL community and providing healthcare guidance and treatment to veterans. Operating his practice and supplement business from Austin, Texas, Kirk is an avid outdoorsman and fitness enthusiast. When he's not working or working out, you can usually find him in nature, continuously enhancing his medical skills. We're continuing our discussion into the intricate relationship between sleep, brain health, and inflammation with Dr. Parsley in this second of two parts. We discuss how sleep deprivation can lead to brain inflammation, along with the surprising effects of everyday activities on cognitive wellbeing. We'll also reveal some experiences with microdosing psychedelics for their potential neuroprotective benefits, and explain the role of peptides and supplements in enhancing sleep quality. Our chat wraps up with cognitive therapy techniques to combat insomnia. In this episode: How sleep deprivation leads to the accumulation of beta-amyloid plaques. Why chronic lack of sleep causes hormonal dysregulation, and the effects Dr. Parsley has seen on Navy SEALs. Examples of activities that can contribute to unexpected brain trauma and inflammation. How blast waves create shearing effects in the brain, leading to cognitive health issues. Why psychedelics like psilocybin may aid in mitochondrial vitality and neuron physiology. How microdosing substances could subtly enhance neurotropic factors and reduce amygdala tone. What role muscle health and mitochondrial function play during menopause. Why peptide therapies, such as Cerebrolysin, are likened to hyperbaric oxygen treatments for brain health. How peptides like Dihexa and BPC-157 contribute to inflammation reduction and neurotrophic growth. How melatonin production is influenced by factors such as blue light and alcohol consumption. Why GABA is crucial for slowing down brain activity and aiding sleep. How supplements like vitamin D3, magnesium, and L-theanine support natural sleep processes. What cognitive behavioral strategies combat insomnia and prepare the brain for rest. Why establishing a routine is key to signaling the body to wind down for sleep. Sponsors Try combining all three of these products into one powerful drink!! Today's sponsors LMNT claim your free 8 pack of LMNT sample flavours to try! @ www.DrinkLMNT.com/KarenMartel Try Kion amino acids and get 20% off your purchase with link http://getkion.com/hormone. Listen to the episode Maximize Your Muscle Growth with Essential Amino Acids with Angelo Keely. Try Timeline's Urolithin A (500mg of Mitopure) and Face Products at https://www.timelinenutrition.com/karenmartel, use coupon code HORMONE for 10% off. Interested in joining our NEW Peptide Weight Loss Program? Join today and get the details here. Join our Women's Group Coaching Program OnTrack TODAY! Karen Martel, Certified Hormone Specialist & Transformational Nutrition Coach and weight loss expert. Visit https://karenmartel.com/ Karen's Facebook Karen's Instagram
Adam Carswell shares one of his Greatest Hits in this Next Level interview with Josh Ketner, Founder of Dream Body Clinic (DBC), on the Liberland Show as they discuss DBC's groundbreaking stem cell therapy and medical treatments for diseases that often get written off as incurable, giving people some of the best options for their current and future health concerns.In this episode, Adam and Josh talk about:The formation and mission of Dream Body ClinicDiseases that DBC treats that traditional medicine says is incurable Adam's treatment experience at DBCThe benefits of DBC's location for their medical practices The benefits of medical treatments like Modafinil, Cerebrolysin and HGH Adam would like to give a huge thanks to Josh for coming on the Dream Chasers platform and sharing his knowledge and experience.Contact Josh Ketner: https://dreambody.clinic/ Watch the Episode: https://youtu.be/Wy-_BSjkQD4 Episode Resources:Adam J. Carswell Facebook Group https://raisingcapitalforrealestate.com/investor-attraction-training-ac-v1 Listen to Adam's music: https://open.spotify.com/artist/7aXBCWkF4GaqldpokuDaiM https://raisefest.com/ Liberland Show: https://www.youtube.com/c/LiberlandOfficial Dream Body Clinic: https://dreambody.clinic/ Adam's Dream Body Clinic Visit: https://youtu.be/H6_w93AAxWw Timestamped Shownotes:00:13 – Host Adam Carswell introduces Josh Ketner, Founder of Dream Body Clinic 00:52 – What inspired Josh to establish Dream Body Clinic and what is the mission of the clinic?04:32 – What are some diseases that Dream Body Clinic treats that traditional medical doctors will say are incurable? 08:05 – What did Dream Body Clinic treat Adam for and how was Adam's recovery process?12:05 – What are the benefits of establishing the Dream Body Clinic in Mexico instead of the US or other countries?17:35 – What is Modafinil used for and how can it improve your health?22:42 – What diseases does Cerebrolysin help treat and what does it do?25:22 – What are the benefits of taking testosterone? 28:42 – What is HGH and what are the benefits of taking it? — — — — — Copyright Disclaimer under Section 107 of the copyright act 1976, allowance is made for fair use for purposes such as criticism, comment, news reporting, scholarship, and research. Fair use is a use permitted by copyright statute that might otherwise be infringing. Non-profit, educational or personal use tips the balance in favour of fair use.This video features materials protected by the Fair Use guidelines of Section 107 of the Copyright Act. All rights reserved to the copyright owners.
When someone has an acute ischemic stroke, urgent, effective, simple and reliable treatments will reduce their risks of disability or dying from their brain tissue damage. The treatments used vary around the world, and a drug called cerebrolysin and its analogues are widely used in post-Soviet countries, Eastern Europe, and Central and Southeast Asia. In October 2023, the latest update of the Cochrane review was published by researchers from Cochrane Russia based at the Russian Medical Academy of Continuing Professional Education and two of the authors, Dilyara Nurkhametova and Liliya Eugenevna Ziganshina, discuss it for this podcast.
When someone has an acute ischemic stroke, urgent, effective, simple and reliable treatments will reduce their risks of disability or dying from their brain tissue damage. The treatments used vary around the world, and a drug called cerebrolysin and its analogues are widely used in post-Soviet countries, Eastern Europe, and Central and Southeast Asia. In October 2023, the latest update of the Cochrane review was published by researchers from Cochrane Russia based at the Russian Medical Academy of Continuing Professional Education and two of the authors, Dilyara Nurkhametova and Liliya Eugenevna Ziganshina, discuss it for this podcast.
Have you ever wondered how your brain stays sharp and focused? There's a fascinating peptide called DIHEXA that plays a superhero role in boosting brain power. Imagine a tiny helper that supports your memory, thinking skills, and overall brain function. In this podcast, we'll cover DIHEXA, understanding what it is, how it works, and the incredible benefits it may offer in optimizing brain function. What is DIHEXA? Think of it as a tiny building block for your brain. This peptide is like a superhero sidekick, helping your brain cells communicate better and ensuring everything runs smoothly. How Does DIHEXA Work? DIHEXA comes from angiotensin IV. Angiotensin IV is a peptide in your body that helps regulate blood pressure and fluid balance. It has many effects on the central nervous system, like helping the process of learning and taking in new information, experiences, and skills (memory acquisition). It also affects our memory recall and object recognition. DIHEXA's secret lies in its ability to enhance a molecule called acetylcholine. Think of acetylcholine as a messenger that helps brain cells talk to each other. DIHEXA ensures plenty of this messenger is around, making communication between brain cells clearer, faster, and more efficient. This means your brain can process information quicker and remember things more effectively. It's like giving your brain a turbo boost! What are the benefits of DIHEXA? First off, it's like a personal trainer for your memory. It helps strengthen your ability to remember things, like your favorite song lyrics or important dates, which can be helpful in people with Alzheimer's. Next, DIHEXA enhances your focus and attention. Imagine concentrating better during class or when you're working on a project – that's what DIHEXA can help you achieve! DIHEXA also supports your problem-solving skills. It's like having a clever friend who helps you solve puzzles faster. Plus, it's been shown to promote overall brain health (mental stamina), keeping your thinking skills sharp as you grow older. What is the typical dose of DIHEXA? DIHEXA can be taken by mouth or used as a topical cream. The typical dose is 20 to 80 mg, 4 to 5 days per week, depending on why you're using it. It's also important to know that you shouldn't use DIHEXA when taking cerebrolysin. We discussed cerebrolysin several weeks before, but I'd like to review what cerebrolysin is and how it helps with cognitive health. Cerebrolysin is a nootropic peptide that supports neurons' growth, survival, and maintenance, aiding in their communication and overall brain health. It may help people with traumatic brain injury (TBI) or stroke recovery and mood enhancement. It can also improve memory, learning, and overall cognitive performance. And the drug's antioxidant and anti-apoptotic properties help protect brain cells from damage and death, potentially slowing down the progression of neurodegenerative disorders like Alzheimer's and Parkinson's. If you or a loved one are considering DIHEXA as a treatment option, consult a qualified healthcare professional to determine its suitability and safety for your specific needs. As science advances, the quest for unlocking the full potential of the human brain remains a fascinating journey, with DIHEXA paving the way for new possibilities in the field of neuropharmaceuticals. Thanks again for listening to The Peptide Podcast, we love having you as part of our community. If you love this podcast, please share it with your friends and family on social media, and have a happy, healthy week! Pro Tips We're huge advocates of using daily collagen peptide supplements in your routine to help with skin, nail, bone, and joint health. But what do you know about peptides for health and wellness? Giving yourself a peptide injection can be scary or confusing. But we've got you covered. Check out 6 tips to make peptide injections easier.
Cerebrolysin – a unique peptide-based drug that has garnered attention for its potential brain-boosting effects. In this podcast, we'll cover Cerebrolysin, understanding what it is, how it works, and its potential benefits in optimizing brain function. What is Cerebrolysin? Cerebrolysin is a nootropic drug developed and manufactured by Ever Pharma, a pharmaceutical company based in Austria and Germany. It's a mix of peptides originally derived from pig brain tissues and processed to create a peptide-based solution rich in neurotrophic factors. These neurotrophic factors are essential proteins that support neurons' growth, survival, and maintenance, aiding in their communication and overall brain health. *The FDA has approved it as an orphan drug (for use in rare disorders like ALS and frontotemporal dementia). However, it's widely used in over 70 countries worldwide. How Does Cerebrolysin Work? The exact mechanism of Cerebrolysin's action is not entirely understood, but it is believed to work through multiple pathways to promote brain health and cognitive function. Neurotrophic Effects: Neurotrophic factors in Cerebrolysin stimulate neuronal growth, maintenance, and repair. These factors aid in forming new connections between neurons, enhancing synaptic plasticity, and improving overall brain connectivity. Antioxidant Properties: Cerebrolysin has demonstrated antioxidant activity, neutralizing harmful free radicals in the brain that can damage cells and impair cognitive function. By reducing oxidative stress, it supports brain cells' longevity and health. Anti-Apoptotic Effects: Apoptosis is a process of programmed cell death. Cerebrolysin has shown anti-apoptotic properties, protecting neurons from premature cell death and preserving brain tissue. Anti-Inflammatory Actions: Chronic inflammation in the brain can be detrimental to cognitive function. Cerebrolysin exerts anti-inflammatory effects, potentially mitigating neuroinflammation and its negative impact on the brain. Enhanced Blood Flow: Improved cerebral blood flow is crucial for delivering essential nutrients and oxygen to brain cells. Cerebrolysin has been shown to increase blood flow, supporting the brain's metabolic demands. What are the benefits of Cerebrolysin? Cognitive Enhancement: Cerebrolysin's neurotrophic effects contribute to improved memory, learning, and overall cognitive performance. It mainly benefits individuals experiencing cognitive decline due to aging or certain neurodegenerative conditions. Neuroprotective Effects: The drug's antioxidant and anti-apoptotic properties help protect brain cells from damage and death, potentially slowing down the progression of neurodegenerative disorders like Alzheimer's and Parkinson's disease. Stroke Recovery: Cerebrolysin has shown promise in aiding stroke recovery. By supporting neuronal repair and enhancing blood flow, it may aid in rehabilitating neurological function after a stroke. Traumatic Brain Injury (TBI) Support: In cases of TBI, Cerebrolysin's neuroprotective effects may assist in reducing damage to brain tissue and promoting recovery. Mood Enhancement: Some studies suggest that Cerebrolysin may have mood-enhancing effects, potentially helping individuals with mood disorders or depression. How do you take Cerbrolysin? Cerebrolysin is typically administered through intramuscular (IM) or intravenous (IV) injections. The dosage and duration of treatment vary depending on the individual's condition and the physician's assessment. Typically given over 2-4 weeks. Repeat doses are based on clinical response and underlying diagnosis. Indications: Stroke, TBI, Vascular Dementia, and Alzheimer's Disease. You can think of this for clinical syndromes that contribute to brain inflammation and oxidative stress. Is Cerbrolysin safe to take? As with any medication, Cerebrolysin may cause side effects in some individuals. Common side effects include headaches, dizziness, sweating, and nausea. Mild allergic reactions at the injection site can also happen. Serious adverse effects are rare, but if experienced, immediate medical attention is necessary. Who shouldn't take Cerebrolysin? - Pork allergy or cultural objection - Unstable seizure disorder - Severe kidney impairment If you or a loved one are considering Cerebrolysin as a treatment option, consult a qualified healthcare professional to determine its suitability and safety for your specific needs. As science advances, the quest for unlocking the full potential of the human brain remains a fascinating journey, with Cerebrolysin paving the way for new possibilities in the field of neuropharmaceuticals. Thanks again for listening to The Peptide Podcast, we love having you as part of our community. If you love this podcast, please share it with your friends and family on social media, and have a happy, healthy week! Pro Tips We're huge advocates of using daily collagen peptide supplements in your routine to help with skin, nail, bone, and joint health. But what do you know about peptides for health and wellness? Giving yourself a peptide injection can be scary or confusing. But we've got you covered. Check out 6 tips to make peptide injections easier.
Iwan and Ben hear from Dr Ayush Sharma, Surgeon Scientist from Ambedkar Central Railway Hospital in India, on his trials exploring a role for Cerebrolysin (https://www.cerebrolysin.com) to help boost recovery after surgery for Degenerative Cervical Myelopathy. This is a recognised research priority.
Adam Carswell shares his Next Level interview with Josh Ketner, Founder of Dream Body Clinic (DBC), on the Liberland Show as they discuss DBC's groundbreaking stem cell therapy and medical treatments for diseases that often get written off as incurable, giving people some of the best options for their current and future health concerns.In this episode, Adam and Josh talk about:The formation and mission of Dream Body ClinicDiseases that DBC treats that traditional medicine says is incurable Adam's treatment experience at DBCThe benefits of DBC's location for their medical practices The benefits of medical treatments like Modafinil, Cerebrolysin and HGH Adam would like to give a huge thanks to Josh for coming on the Dream Chasers platform and sharing his knowledge and experience.Contact Josh Ketner: https://dreambody.clinic/ Watch the Episode: https://youtu.be/Wy-_BSjkQD4 Episode Resources:Adam J. Carswell Facebook Group | RaiseMasters | Liberland Show - Episode 96 with Josh Ketner | Liberland Show | Dream Body Clinic | Adam's Dream Body Clinic Visit | Carswell.ioTimestamped Shownotes:00:08 – Host Adam Carswell introduces Josh Ketner, Founder of Dream Body Clinic 00:47 – What inspired Josh to establish Dream Body Clinic and what is the mission of the clinic?04:25 – What are some diseases that Dream Body Clinic treats that traditional medical doctors will say are incurable? 07:58 – What did Dream Body Clinic treat Adam for and how was Adam's recovery process?11:59 – What are the benefits of establishing the Dream Body Clinic in Mexico instead of the US or other countries?17:29 – What is Modafinil used for and how can it improve your health?22:37 – What diseases does Cerebrolysin help treat and what does it do?25:16 – What are the benefits of taking testosterone? 28:36 – What is HGH and what are the benefits of taking it?
To watch this as a video Download it and play it from the Downloads section in the Castbox app on your device.Cerebrolysin's primary clinical purpose is the treatment of neurodegenerative diseases but as any informed Biohacker knows, few drugs are designed for the specific purpose of upgrading performance in otherwise healthy people. In this regard, Cerebrolysin has a similar research profile to other popular smart drugs I'm well acquainted with...The most significant benefit that otherwise healthy people can expect from Cerebrolysin thanks to its Neurotropic mechanism is improved long-term memory.
In this episode, Dr Kent Holtorf and I talk about how he first found peptides and how they have transformed his health and the way he practices medicine. We then discuss the oral peptides available through Integrative peptides TB4Frag for repair and immune support, BPC 157 for repair, KPV for inflammation and CerebroPep for the brain and what’s coming next…. Meet this week’s guest: Kent Holtorf, M.D. is the medical director of the Holtorf Medical Group and a founder and director of the non-profit National Academy of Hypothyroidism (NAH), which is dedicated to the dissemination of new evidence-based information to doctors and patients on the diagnosis and treatment of hypothyroidism and advanced integrative diagnostic and treatment protocols. He has personally trained numerous physicians across the country in the use of bioidentical hormones, hypothyroidism, peptide therapy, stem cell therapy, complex endocrine dysfunction and innovative treatments of chronic fatigue syndrome, weight loss, fibromyalgia, and chronic infectious diseases, including Lyme and related diseases. Lyme and associated diseases have been the focus of the Holtorf Medical Group centers and have been a passion of Dr. Holtorf’s for over 15 years. To try these for yourself: IntegrativePeptides.com use Promo Code Longevity10 to get 10% off Key Takeaways: 2:12 How Dr Holtorf found Integrative Medicine 4:30 His health journey through med school that led to starting National Academy of Hypothyroidism, a nonprofit thyroid association 6:42 How discovering hangover free beer led to the founding of a Beer Company 8:47 Opening up 2 centers, his stressful divorce, experiencing the difficult times 9:50 Then Dr Holtorf found peptides …. Everything changed from there 12:01 In very ill patients peptides can revive the immune system so that fewer antibiotics can get the job done 15:28 When you look at the way the body works, we think of signaling it's kind of like hormones 16:17 BPC puts the body back in homeostasis 17:25 How the thymus peptides restore balance in the immune system 24:38 The link between Autoimmune conditions and infections 26:30 They do initial panel, they can pick out who has these multisystem illness and how bad it is 28:42 Thymosin alpha 1 36:00 KPV - orally bioavailable suppresses mast cells, busts biofilms, anti candida… 39:00 How can BPC be so big a molecule and still be orally bioavailable? The rule of 5.. 42:47 BPC 157 may protect EMF’S through stabilization of cellular calcium channels 48:34 TB4 supports autophagy by supporting mitochondria 50:00 TB4 and cancer - rushing to the rescue? 54:13 CerebroPep - Integrative Peptide’s oral version of Cerebrolysin 59:19 Coming soon: Peptigenic, an analgesic stem cell cream with peptides in it 1:07 Heavy Metals often don’t cause issues till there’s an infection involved Linkage: Dr. Richard Horowitz DNA ConneXions Peptigenic Connect: www.NAHypothyroidism.org www.HoltorfMed.com www.integratedpeptides.com (Use code LONGEVITY10 to get 10% off your purchase) Disclaimer: Please note that this content is intended for information purposes only and is not intended to substitute professional medical advice, diagnosis or treatment. Before changing your diet or using any new supplement make sure to consult with your care provider. Always seek the advice of your physician or care provider with any questions or concerns you may have regarding a medical condition before you make any changes.
Suzanne Turner – Improving Boardroom Cognition Supercharge your brain to perform at its highest level with peptides, nootropics and much more!! In this episode I have a great discussion with Dr Suzanne Turner and dig into the ways she helps her patients to keep their brains young and optimized no matter what their age so that they can enjoy as good (if not better) function in their later years as they did in their prime. If you’re still in your prime you will get a ton of value from this episode too as many of these are also great strategies to optimizes a young brain. Dr Suzanne Turner is the founder of Vine Medical Associates. She is double Board Certified in Family Medicine and AntiAging and Regenerative Medicine, she treats rare and unusual diseases in patients from around the world. Practicing Functional Medicine, Dr. Turner is an industry expert and speaker on bioidentical hormone therapy, metabolic medicine, neurodegenerative disease, and human performance optimization. She has earned Advanced Certification in Endocrinology and Peptide Therapy and is the leading expert in peptide therapy in the Southeast. Among her many accomplishments, Dr. Turner served as a physician in the U.S. Navy for several years. Prior to her tour of duty, she did an internship in general surgery, then completed her residency at Emory University. Dr. Turner is also an award-winning teacher of medical students and is on the faculty of A4M, IPS, ACAM, and SSRP. 05:44 Why Dr Turner picked Boardroom cognition as a topic to deep dive into: and, what busy moms and boardroom executives have in common 14:25 Sleep a critical piece of the puzzle 19:50 How many hours it actually takes the brain to get into ketosis and why this is so important to cognitive health 22:50 The best time to have a glass of wine to mitigate negative effects 24:53 The cellular impact of alcohol 26:44 Muscle – the currency of aging 27:26 Resistance training as a strategy to decrease the need for insulin in diabetics 28:08 A healthier way to mitigate oxidative stress Ketone Esters instead of antioxidants 29:20 Hydration for cognitive performance 33:47 Hormone Optimization as a strategy to optimise cognitive function 35:23 Optimizing immune function –for brain performance – Thymosin Alpha 1 the first peptide in your stack 37:08 The magic of the 40 Day or 6 week cycle 38:23 DiHexa and how to use it for maximum benefit 43:20 When it makes sense to introduce Selank and Semax 44:11 How GLP1 Agonists fit in to supporting cognitive performance and why nobody talks about them for this purpose 45:10 Cerebrolysin – how and when to use for cognitive support/performance, stacking with DiHexa for the win 51:41 Nootropics that can work and bring added value – the ones to exercise caution with – from Qualia Mind to Mucuna, Phenibute, to L Carnitine 56:00 Modafinil – great for the right person but beware the “Elvis Syndrome” 57:56 Spermidine, how it supports autophagy in the brain and how this too can support optimal function 58:55 Rapamycin to clear senescent cells that could be clogging “pathways” for “cognitive decline” prevention, when to take it for optimal results. Links: Vine Medical: https://vinemedical.com Dr Turner’s Website https://drs.md/ Instagram https://www.instagram.com/drsturner/ Facebook https://www.facebook.com/DrSCellularMedicine QualiaMind http://bit.ly/QNHNat Promo Code: NN15 for 15% off Primeadine (Spermidine Supplement I recommend) Primeadine.com BIONAT15 for 15% off your purchase Please note that this content is intended for information purposes only and is not intended to substitute professional medical advice, diagnosis or treatment. Peptides are for the most part classified as research chemicals so should not be used on humans. Before changing your diet or using any new supplement make sure to consult with your health care provider. Always seek the advice of your physician or health care provider with any questions or concerns you may have regarding a medical condition before you make any changes.
When embarking on a transformational healing journey, it is important to be aware of all of the options that you have available. In today’s episode, Dr. Minni sheds light on peptide therapy, one of the most effective methods of treatment for a variety of conditions. We first hear about Dr. Minni’s approach to medicine and how her own struggles with PCOS led her down a path of discovery, where she found functional medicine. We then hear about how peptide therapy works, its specific nature, and why it’s so well-tolerated by the body. After this, Dr. Minni walks us through some of the peptide therapy treatments available, including AOD-9604, Bremelanotide, Cerebrolysin, and Delta Sleep Inducing Peptide, and the conditions they are used to treat. As an exciting potential treatment to help you overcome whatever disease you are suffering from, peptide therapy is certainly worth learning more about. Be sure to tune in today!Key Points From This Episode:Hear how Dr. Minni found functional medicine after struggling with her own PCOS.The power of the mind and the role it plays in healing.Dr. Minni’s three-pronged transformational healing approach.An overview of peptide therapy and how it works to help your body heal.Why the highly specific nature of the peptides makes them so effective in treatments.Some of the conditions that peptide therapy can be used to treat.Learn more about the various peptide therapy options that are available.Tweetables:“There are so many new cutting-edge treatments that are available these days that can help you not only with your health, but also prevention of diseases.” — Dr. Minni Malhotra [0:00:59]“Peptide therapy is an exciting cutting-edge medical science that uses specific amino sequences called as peptides.” — Dr. Minni Malhotra [0:03:18]“If you’re looking to get that cutting-edge method, or the science and heal your body, whether it’s a hormone, whether it’s a neurotransmitter, whether it is to reduce stress, or to boost your immune system, we have it all these days and it is so easily available.” — Dr. Minni Malhotra [0:16:59]Links Mentioned in Today’s Episode:Anchor Wellness Center
Dr. Elizabeth Yurth is the Co-Founder and Medical Director of Boulder Longevity Institute, where she has been providing Tomorrow's Medicine Today to her clients since 2006. That means she is the biohackers doctor .Along with her 25-plus years practicing orthopedic medicine, Dr. Yurth is Board Certified in both Physical Medicine & Rehabilitation and Anti-Aging/Regenerative Medicine. She has a Stanford-affiliated Fellowship in Sports and Spine Medicine, and a dual Fellowship from A4M in Anti-Aging and Regenerative Medicine. She has also completed a Fellowship in Human Potential and Epigenetic Medicine, is part of the first cohort of providers to receive the A4M National Peptide Certification, and is a faculty member and national lecturer for both A4M and the International Peptide Society (IPS). As an athlete herself who has dealt with numerous injuries, Dr. Yurth is thrilled to share with her clients all the innovative, life-changing treatments that are on the cutting-edge of medicine. Dr. Elizabeth shared on how she got started, and whether she would ever leave the sick care system behind fully. She also discussed some of the challenges of running a traditional practice. Dr. Elizabeth shares the treatment that has significantly improved outcomes for arthritic patients, along with her peptide mainstays and favorites. Surgery vs regenerative therapies. PRP, Stem Cells Peptides Dealing with Arthritis Factors to consider in picking an orthopedic doctor Life optimization strategies How to avoid injuries while exercising. The structure of allopathic medicine has turned doctors from true healers into bureaucrats. If people over the age of 50 moderated sugar and minimized alcohol, they would double their expected life span. The best peptides at the moment include 5-amino 1MQ, GHK Copper, and Cerebrolysin. At the start of the show, Dr. Elizabeth shared on how she got started, and whether she would ever leave the sick care system behind fully. She also discussed some of the challenges of running a traditional practice. Dr. Elizabeth shares the treatment that has significantly improved outcomes for arthritic patients, along with her peptide mainstays and favorites. Dr. Elizabeth is the biohacker's doctor, with 25 years of practice. She is the co-founder and medical director of Boulder Longevity Institute. Elizabeth is an orthopedic, anti-aging and regenerative medicine practitioner, and a leading physician in the peptide space. Visit http://boulderlongevity.com/ for more information. Biohacking is a huge part of being optimized, and peptides are the most game-changing biohacking tools in our arsenal. ACOUSTIC WAVE MEDICAL GRADE FDA REGISTERED ERECTILE DYSFUNCTION THERAPY AT HOME, AT A FRACTION OF THE COST Get More Information and Get the Rocket Here Catch My Interview With Dustin Wolff The co -inventor of the rocket.
In this podcast, we will discuss nootropics, anti-aging, and healing/enhancement peptides. https://mybiohack.com/blog/cerebrolysin-epitalon-bpc157-ghkcu-lgd4033-ostarine-mk-677 If you can get a prescription from a doctor, then use Tailor Made Compounding for high quality peptides. If you can't then using other high quality sources are also available: Cerebrolysin - combination of BDNF, NGF, GDNF, and CNTF Epitalon - longevity BPC-157 - gut health/neurotransmitter balance GHK-cu - skin health/wound healing Ligandrol (LGD-4033) - prevents muscle wasting Ostarine (MK-2866) - muscle mass Ibutamoren (MK-677) - long acting ghrelin mimetic
Peptides will most likely be a familiar term for most listeners of this podcast, with the awareness of their benefits and effects growing steadily during the last part of the 20th century and into this one. Today we are joined by Ryan Smith, one of the top three leading experts on the subject of peptides! He is the CEO of Tailor Made Compounding, a company out of Kentucky that has now gone international. He is here to discuss the impact of peptides, the effects of certain products and just share his general genius for this area of knowledge. It has become clear that peptide use, amongst so many other types of supplements and health science, is the most tissue-specific treatment modality and Ryan shares so much about how this all works in many different cases. You are not going to want to miss out on a second of this conversation! He gets into so many different products, some of which might be familiar and many you may not have heard of too. Do not forget to visit our unbelievable show sponsors, BLUblox. Get 15% off my favorite blue light-blocking glasses from BLUBlox at https://blublox.com/muscleintelligence using the code MUSCLE Timestamps Ryan's work in the realm of peptides and the two approaches his company takes. [2:55] The history of peptides, important discoveries and mainstream awareness. [4:49] Two mechanisms for peptides and different long term benefits. [6:58] A broad-stroke approach with growth hormone versus more precise means. [10:06] Thoughts on the concerns about growth hormones and different types of cancers. [15:53] The excitement around NA-1 and its efficacy in fighting cancer and viral illnesses. [17:09] Dosing schedules and the mechanistic, inner workings of Epitalon. [18:58] Sleep benefits, daily dosage times and fitting into a natural pulse. [20:28] Using peptides to stimulate the pituitary and the effects on sleep. [21:42] The range of mitochondrial peptides that Ryan is working with at the moment. [25:56] The fat loss dimension to this conversation and the results seen so far. [27:21] Ryan's thoughts on the popular BPC-157 and who could use it for best results. [31:11] The products that Ryan is most excited about in terms of brain optimization. [34:07] Statistics for Dihexa and how it compares to other products. [37:08] Cerebrolysin and the results that have been noted in cases of stroke and TBI. [41:27] The areas that Ryan is most excited about currently in the peptide space. [45:25] The process of FDA approval and listing of available products. [47:58] Potential negative effects of peptides; side-effects and allergies. [4:26] Understanding lipopolysaccharides and avoiding some serious health dangers. [50:30] Regulation and legality; avoiding dangerous products from unknown sources. [52:07]
Ryan Smith co-founded Tailor Made Compounding Pharmacy with a passionate interest in offering peptide therapy, a category of biosimilar proteins with >100 FDA-approved products and 10,000+ products in development, many of which we prescribe to patients at the Center for Healing Neurology. In the first part of this show, we talk about what they are, how they work, why peptides as a category have such few side effects and have such a positive safety profile. In the second part of the show, we dive into specific peptides including neurocognitive and mood peptides (Cerebrolysin, Selank, Semax, Dihexa, FGLL), peptides to target the immune system for chronic disease like Lyme as well as acute viral infection including the flu (Thymosin Alpha-1, ARA 290), peptides for repair & recovery (thymosin beta 4, BPC-157), peptides for mitochondrial support (SS31, MOTS-C) and cosmetic and beauty products including topicals with botox-like action (GHK-Cu, Argeline). Don't miss this incredibly informative show for the innovative ways you can address your health needs and goals.
You are in for a real treat today because, as a Christmas gift from me to you, I’m sharing one of the biggest and most thorough episodes I’ve ever released. Ben Greenfield came over to my house and we went through every single supplement, smart drug, nootropic, herb, and biohack on the entire property. We then turned this into a full-length documentary film and this monster of a podcast. I learned so much from Ben while we did this, and there is just so much valuable information packed into this episode. I am really happy with how it all came together and I am stoked to finally be sharing it with all of you! I’ve been asked on multiple occasions how we can live our lives without either moving into the middle of nowhere or sacrificing some aspect of our physical, mental, and emotional health. Well, here you go — the complete biohacker’s guide to living an optimal life in the city in 2020. Kitchen Supplements... (17:25) Deuterium-depleted water (DDW) Lifestylist Podcast Deuterium Episodes Premade Paleo meals (Model Meals) Ben's diet: organ meats, wild-caught fish, legumes, underground veggies (Northern European) Four Sigmatic Lion's Mane Psilocybin (Albino A + Strain) Deprenyl Life Stylist Podcast w/ Dr. Ted Achacoso Troscriptions Troche w/ CBD, nicotine, caffeine, & methylene blue (pharmaceutical grade) Limit ice baths to 10 minutes (affects blood glucose deleteriously) Blood glucose monitor Visoluten peptides for the eyes SKQ1 active ingredient Visomitin eye drops Reversed retinal damage and blindness in rodent models Vision Gym Vishen Lakhiani has publicly experimented with it BGF podcast w/ Vishen Lakhiani Oxytocin (feel-good trust hormone released with breast-feeding, physical contact, sex, etc.) Pink Fluff LSD (1 drop is 1/20 of a hit of acid, 5 mcg) Yohimbine HCl Kion Lean Assists w/ healthy blood sugar management Good supplement w/ cold thermogenesis Peptides… (43:20) BPC 157 Tailor Made Compounding BGF podcasts w/ Dr. Matt Cook TB 500 DSIP (Deep sleep-inducing peptide) PT 141 (aphrodisiac) Nitroglycerine cream (contact Dr. Koniver at Koniver Wellness for prescription) Melanotan Ketamine BGF podcasts about peptides How To Use BPC-157: A Complete Dummies Guide To Healing The Body Like Wolverine. International Peptide Society Superfoods… (51:30) Surthrival Pine pollen (reproductive benefits) Piracetam (cognitive benefits) Dihexa topical cream Cerebrolysin intranasal spray Semax Qualia Mind Modafinil Exogenous ketones – perfect keto Beta-hydroxybutyrate Kion Coffee… (59:00) Ranks very high in “cupping” score Beans are hand-selected for symmetry (roasting quality) Organic beans (3% of beans in the world are organic) Nitrogen flushing packaging w/ roast date on the bag Coffee Gator Grind fresh right before you make it (oxidation) How to hack your own structured water Live Spring Water (lower deuterium content) Joovv Infrared light Is all water the same – BGF podcast with Dr. Gerald Pollack BGF article about structured water and the interview with Dr. Gerald Pollack Somavedic Pristine Hydro Water Filter TrueDark light dot stickers wrapped around light bulbs and fridge lights RA Optics blue light blocking glasses Red light incandescent bulbs BioBalance Final thoughts in the kitchen… (1:09:10) Find what works for you Ancestral Supplements organ meat capsules Kion Fish Oil Creatine Nootropics Depot Try just one or two things at a time, don't be overwhelmed with the volume of info shared in this show Get really good, clean water Focus on the best sleep possible Red light incandescent bulbs Earthing and grounding Kratom for pain relief Leaf of faith documentary Mind Bullet Kratom Bedroom and Bathroom Air quality… (1:25:40) Ozone Generator Ozone to the brain via the ears Ozone bagging for limbs Book: The Ozone Miracle by Frank Shallenberger HEPA Air purifier (Austin Air) Molekule air filter EMF kill switch Spinal decompression… (1:34:45) Pristine Hydro water filter Saunders Lumbar Home Track Dr. Ho's decompression belt BioMat Pro Vielight Power Medic laser Joovv Go Sleep optimization… (1:51:20) Ooler sleep system Take a cold shower before bed when in a warm place w/ no AC GeoVital shielding mat (clears geopathic stress zones) Life Stylist Podcast w/ building biologist Brian Hoyer Lambs clothing (shields EMF) PEMF grounding mat The bathroom… (2:00:00) Pristine Hydro double Shower Filter Omica Shower Filter BluShield cube Somavedic The Zen Den Devices and gadgets… (2:12:40) Joovv panel Biocharger NuCalm Dispenza Meditation Vital Reaction hydrogen inhaler Clearlight Sauna Belicon Rebounder NanoVi Cellular Repair Technology Homemade ice bath… (2:26:00) Luke's budget freezer hack More about this episode. Watch it on YouTube Connect with Luke on social media to learn how to take your lifestyle to the next level, plus catch exclusive live interviews & events: INSTAGRAM - @lukestorey // https://www.instagram.com/lukestorey/ FACEBOOK - https://www.facebook.com/MrLukeStorey/ TWITTER - @MrLukeStorey // https://twitter.com/MRLUKESTOREY YOUTUBE - https://www.youtube.com/c/LukeStorey THIS SHOW IS BROUGHT TO YOU BY: ONDA WELLNESS. If you’re a discerning health enthusiast like myself, you’ve probably sat and scratched your head at the health food store trying to figure out which CBD product you should buy. They all make big claims, they all say they’re the best, but what actually works? Well, I just found a brand that I’m super stoked about, and I want to share it with you: ONDA offers a patented and truly full-spectrum line of products that aren’t dependent on the use of alcohol, CO2, or other solvents for extraction – and this is important because when you’re getting the medicine out of the plant, you don’t want to add poisons to it! You can try it for yourself and get 15% off using code LUKE15 at ondawellness.com. AND... RA OPTICS. These Blue Blocking glasses are the premium level protection for sleep and health. They block the entire harmful blue spectrum and even most green up to 550nm to preserve your most powerful agent of health: melatonin. Ra Optics uses the highest quality lens technology in the most attractive frames on the market. This means you can wear them out in public at night and feel confident in both your style and the knowledge that you're preserving the one thing that determines health above all others: quality sleep. You can save 10% on your pair of blue-blocking glasses using the code “lifestylist” at raoptics.com. AND… JOOVV. If you’ve been listening for a while or following Luke on social media, you’ve probably seen him raving about red light therapy, or photobiomodulation. There are over 3000 published clinical papers on light therapy – over 200 being double-blind, randomized, and placebo-controlled – making this arguably the most well-researched bio hack in Luke’s arsenal. Some of the benefits include increased skin health, better muscle recovery, better sexual performance, and reduced joint pain and inflammation. So you can see why Luke is so into it... and why all of his friends keep coming over to use his Joovv device! If you are ready to get your own Joovv device + a FREE gift, head over to Joovv.com/luke and enter the code “LUKE” at checkout. HELP SUPPORT THIS SHOW! Love the Show? Youʻll really love Lukeʻs Master Market Online Store! It’s a win/win! 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Biohacking is a huge part of being optimized, and peptides are the most game-changing biohacking tools in our arsenal. What are some of the next level, less well-known peptides that are available on the market? How can arthritic and orthopedic patients fix the root cause of their bone issues? Why do we need to stop trying to use data to predict life patterns? On this episode, I’m joined by renowned orthopedic, anti-aging, regenerative physician and peptide expert, Dr. Elizabeth Yurth. She shares on how we can biohack our way to better health with peptides. Three Takeaways The structure of allopathic medicine has turned doctors from true healers into bureaucrats. If people over the age of 50 moderated sugar and minimized alcohol, they would double their expected life span. The best peptides at the moment include 5-amino 1MQ, GHK Copper, and Cerebrolysin.
This is episode 5 in our Peptide Series. In this episode, Ryan Smith and I discuss the Peptides we have seen be clinically effective for cognitive function and improving memory. The peptides we discuss in this podcast are Cerebrolysin, Dihexa, and Aniracetam. Click here to view the video on Dihexa that we discuss in the podcast. To learn more about peptide therapy, click here. Dr. Matt is the host of the Ethos Athletes Podcast and is a co-owner of Ethos Integrative Medicine in Scottsdale, AZ. Dr. Matt specializes in Regenerative Orthopedics and Sports Medicine, providing advanced minimally invasive (non-surgical) treatments to athletes.
This is episode 3 in our Peptide Series. In this episode, Ryan Smith and I discuss the Peptides we have seen be clinically effective for treating joint pain and sports injuries. The peptides we discuss in this podcast are BPC-157, TB4, AOD + HA, Pentosan Polysulfate, Cerebrolysin, and GHK-Cu. To learn more about peptide therapy, click here. Dr. Matt is the host of the Ethos Athletes Podcast and is a co-owner of Ethos Integrative Medicine in Scottsdale, AZ. Dr. Matt specializes in Regenerative Orthopedics and Sports Medicine, providing advanced minimally invasive (non-surgical) treatments to athletes.
When someone has an acute ischemic stroke, urgent effective, simple and reliable treatments will reduce their risks of disability or dying from their brain tissue damage. The treatments used vary around the world, and a drug called cerebrolysin is widely used in post-Soviet countries, Eastern Europe, Central and Southeast Asia. In April 2017, the latest update of this review was published by researchers from Kazan Federal University in Russia and Chinara Razzakova, a PhD student from the university interviewed one of the authors, Liliya Eugenevna, for this podcast.
When someone has an acute ischemic stroke, urgent effective, simple and reliable treatments will reduce their risks of disability or dying from their brain tissue damage. The treatments used vary around the world, and a drug called cerebrolysin is widely used in post-Soviet countries, Eastern Europe, Central and Southeast Asia. In April 2017, the latest update of this review was published by researchers from Kazan Federal University in Russia and Chinara Razzakova, a PhD student from the university interviewed one of the authors, Liliya Eugenevna, for this podcast.
When someone has an acute ischemic stroke, urgent effective, simple and reliable treatments will reduce their risks of disability or dying from their brain tissue damage. The treatments used vary around the world, and a drug called cerebrolysin is widely used in post-Soviet countries, Eastern Europe, Central and Southeast Asia. In April 2017, the latest update of this review was published by researchers from Kazan Federal University in Russia and Chinara Razzakova, a PhD student from the university interviewed one of the authors, Liliya Eugenevna, for this podcast.
Peptides are a grouping of 50 or fewer amino acids (more than 50 is a protein). Peptides are natural substances, though those covered in the show are variations on the naturally occurring versions. They can be beneficial in many ways, often amplifying the body’s ability to heal itself. They discuss the history of the use of peptides in a medical environment, as well as the future of peptides becoming available commercially in the U.S., with over 7,000 in clinical development currently. Cancer research is one of the leading development areas for peptides (ALRN-6924 is one of the prominent ones studied). Antimicrobial research is also being done to potentially create new antibiotics. There are different methods of delivering peptides to the body. They are not very bioavailable orally and are prone to hydrolysis, so injection is the best for the majority of peptides. They explore some of the benefits of peptides over traditional medications, such as allergic reaction is limited with peptides, and neither the kidneys nor liver have to process them like traditional medications require. They also consider the potential side effects of using peptides. They warn against purchasing peptides from online companies, as many of them are produced overseas in bulk without any regulation, often not containing what they claim. The only safe way to get access to peptides is through a reputable doctor who practices integrative medicine, with access to compounding pharmacies like Tailor Made Compounding. Some of the peptides covered on the show: Human growth hormone (HGH) secretagogues like Ipamorelin, CJC-1295, Sermorelin and Tesamorelin encourage the pituitary gland to increase HGH production. They also explain the significant risks of using human growth hormone therapy directly. GLP-1 and Semaglutide could be used for diabetes treatment. Melanotan 2 stimulates melanocytes to produce melanin, causing a tanned appearance of the skin. Epitalon resets the HPA (hypothalamic-pituitary-adrenal) axis, with a number of potential positive effects on disease states, possibly helping to lengthen or preserve the length of telomeres, increases melatonin for better sleep and more. BPC-157 is orally bioavailable, unlike most peptides, with a variety of reported benefits. This includes helping with neural inflammation, muscle improvement, improved immunity, improved collagen synthesis, increased bone density and accelerated recovery/healing. It is most often used clinically to treat gut and bowel issues and tendon and ligament repair. Thymosin beta-4 is beneficial for soft tissue injury by increasing blood flow to the area, encouraging healing. Thymosin alpha 1 is FDA approved (commercially available as ZADAXIN™ for treatment of viral hepatitis), encouraging increased immune response to some cancers, Lyme disease and sexually transmitted diseases. PT-141 has a benefit for treating some erectile dysfunction and female sexual dysfunction. Follistatin (actually a protein, not a peptide) has the potential to inhibit myostatin, which prevents muscle breakdown. Cerebrolysin is a combination of peptides with potential useful for brain repair in neurodegenerative conditions such as Alzheimer’s, Parkinson’s and strokes. Selank and Semax are Russian peptides that are nasally bioavailable that have been reported to help with anxiety. MIF-1, ACTH, Dihexa have limited research but have been considered to help with depression, bipolar disorder and PTSD. IGF1 has nerve regenerative capabilities. GDF11 may be beneficial in tissue repair, so useful in anti-aging, but with potential health drawbacks. About the guest: Ryan Smith attended Transylvania University and double majored in Philosophy and Biochemistry. In that time, he had multiple research internships at the University of Kentucky and University of Pennsylvania, studying large scale protein synthesis and physical chemistry. After graduation, he attended medical school at the University of Kentucky for 2 years. After finishing all the educational curriculum and passing USMLE Step 1, he decided to leave and help open up a pharmacy in the United States that focuses on peptide synthesis and formulations for pharmaceutical preparations. Since that time, Tailor Made Compoundinghas become licensed in over 45 states and territories, including Dubai, and has become the leader in the compounding of peptides and proteins for pharmaceutical use. Follow Tailor Made Compounding on Facebook @TailorMadeCompounding and Twitter @TMCompounding.
After a four week course of Cerebrolysin, two cyborgs are ready to share their results. Listen in to learn what Brian and Tim have determined about this promising neruotrophic compound.
Peptides aren’t just the new trendy thing in health. They are vital for addressing so many conditions and diseases. What are some of the many different health concerns it can be applied to? Why is selectivity so important if you’re using peptides in the long-term? What are the best peptides for building muscle? On this episode, we talk to VP of Business Development at Tailor Made Compounding, Ryan Smith, to go deep on peptides and their applications. Three Takeaways The people who hold the money in the sick care model are not the doctors or the patients-- it’s third-party payers and insurance companies. The only people who benefit from SARMs are people selling it underground. Falstatin for human therapy is tricky because it hasn’t been thoroughly tested. Thymosin beta-4 and BPC are repair and recovery products that athletes should be able to use. At the start, Ryan shared how he got started in the industry, and we talked about the problems with the sick care model. We then discussed the strengths and benefits of peptides, muscle-building peptides, and dealing with hypertrophy. Toward the end, we discussed Cerebrolysin for anxiety, opiate-withdrawal and pain management. We also covered: Using tesamorelin and ipamorelin Whether SARMs are really worth it How peptides can benefit injured athletes The sick care model has completely failed. People get worse, become dependent on drugs, and never get healthy. This is what’s driving the interest and use of peptides. They are the future of medicine because of just how many health and optimization problems they can solve. Peptides are great because they don’t have many side effects from a metabolizing standpoint, and you don’t have to worry about drug interactions. Guest Bio- Ryan is the VP of Business Development at Tailor Made Compounding. Go to https://tailormadecompounding.com/ for more information.
Two cyborgs share their first thoughts after beginning a 4-week course of Cerebrolysin-- an cocktail of neural peptides that has been very successful in the treatment of certain types of dementia and Alzheimers. This augmentation is an exciting step because there is some evidence that Cerebrolysin also can improve cognitive function in healthy adults.
Two cyborgs talk about Cerebrolysin - an interesting nootropic backed by credible scientific research. Is this upgrade worth the stress of repeated IM injections? Lets consider.
The preliminary results of Cerebrolysin in patients with Acute ischemic STroke in Asia (CASTA) were presented at the 2010 World Stroke Congress in Seoul, Korea. CASTA is a double-blind, placebo-controlled, randomized trial to evaluate the safety and efficacy of Cerebrolysin. The trial included patients from more than 50 participating centres with acute ischemic hemispheric stroke who were randomized within 12 hours of symptom onset to treatment (30 ml Cerebrolysin diluted in physiologic saline) or placebo (saline) given as intravenous infusion once daily for 10 days. Carmen Lahiff-Jenkins, Managing Editor of the International Journal of Stroke spoke to leader in the field of stroke and strokeologist with considerable clinical trial experience, Professor Stephen Davis who has also been a member of an independent data and safety monitoring committee and has attended some advisory board meetings for the CASTA trial.
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