Podcasts about ttx

Debbie Gordon is the founder and CEO of Cloud Range, the industry-leading cyber range and simulation training platform that measurably decreases cybersecurity exposure and overcomes the staggering cyber skills gap. In this episode, she joins host Charlie Osborne to discuss tabletop exercises, also known as TTX, including what they are, potential benefits for organizations, best practices, and more. Debbie is also featured on our list of Cybersecurity Pundits. • For more on cybersecurity, visit us at https://cybersecurityventures.com.

The Chinese Communist Party (CCP) aims to “reintegrate Taiwan,” effectively stripping the Taiwanese people of their de facto independence. Achieving this takeover with minimal military action and limited long-term damage to Taiwan's infrastructure and economy would offer the CCP substantial economic, diplomatic, and military advantages. A well-executed, well-resourced, and well-timed cyber-enabled economic coercion campaign could provide the CCP with such an opportunity.To explore these threats, a delegation of FDD experts recently visited Taiwan to conduct war games and tabletop exercises (TTXs). These simulations were designed to evaluate the most salient and dangerous threat scenarios posed by the CCP to the Taiwanese people. The TTX involved 20 participants, primarily from Taiwanese banking and finance sectors, who simulated the roles of senior policymakers in Taiwan, the United States, and China. They assessed the most likely and perilous actions the CCP could take to isolate and coerce Taiwan short of outright warThe TTX produced several key recommendations to enhance economic, cyber, and societal resilience, and offered insights into how the United States and its allies can support Taiwan in its struggle for autonomy. To discuss these findings, FDD's Craig Singleton and RADM (Ret.) Mark Montgomery are joined by Ti-Chen Chen of the Taiwan Academy of Banking and Finance and Ben Jensen of the Center for Strategic and International Studies. Lili Pike of Foreign Policy will moderate the discussion and FDD Founder and President Cliff May, who headed the delegation to Taiwan, will deliver introductory remarks.For more, check out: fdd.org/events/2024/10/04/targeting-taiwan-beijings-playbook-for-economic-and-cyber-warfare/

- For those that don't know you, can you tell us a bit about your background and your current role?- I know you help lead the ATLAS project for MITRE, what exactly is ATLAS and how did it come about?- The AI threat landscape is evolving quickly, as organizations are rapidly adopting GenAI, LLM's and AI more broadly. We are still flushing out some fundamental risks, threats and vulnerabilities to consider. Why is it so important to have a way to characterize it all?- When it comes to AI Security, there is also a lot of hype, buzz and dare I say FUD out there. Why are you so adamant that we take a data-driven and actionable approach?- I know you recently helped participate in the first big AI security incident focused TTX, including with CISA and other Government and Industry partners, can you speak a bit about the experience and why exercises like this are important for organizations to do when it comes to AI security?- As someone close to the AI domain, when it comes to security, what are your thoughts on both where we're headed for security of AI, and AI to bolster security? - For folks wanting to learn more about ATLAS, and the work MITRE is doing around AI security, where should folks get started?- What are some key open questions and opportunities for the community to help shape the future of AI security and assurance?https://atlas.mitre.org/ ← Check out MITRE ATLAS!

Les Poissons-globes ou -ballons, au sourire si doux et au corps si gonflable, sont de sympathiques célébrités des récifs. Ils font partie de la famille des tétraodontidés. Ce nom vient du grec tetra-odon: “quatres dents”. En effet, ces poissons semblent avoir quatre énormes dents soudées, un peu comme des enfants.Cette famille donne son nom à l'ordre des tétraodontiformes de nos épisodes. Cet ordre rassemble pas mal de célébrités des océans : les Balistes (Triggerfish), les Molidés (Poisson-lune), les Diodons (Poissons porc-épic) et les Poissons coffres…Les Poisson-ballons vivent dans les récifs dans les eaux tropicales et subtropicales. Ils y mangent des algues, du zooplancton et des coquillages.Les Poissons-globes sont loin d'être des F1. Avec leur étrange sourire, ils seraient même plutôt très droopy comme lascars. Mais pour se défendre, ils peuvent se gonfler en cas de danger. Ils avalent de l'eau très rapidement. C'est exactement le même principe que la Grenouille qui veut montrer qui c'est Raoul au Bœuf;) Dissuasif pour un éventuel prédateur. Une membrane derrière leurs dents leur permet de retenir cette eau dans leur estomac extensible.Les Poissons-globes sont ceinture ET bretelles. La plupart possède une autre arme mortelle : la tétrodotoxine (TTX), un poison plus ou moins foudroyant qui neutralise les organes vitaux de celui qui l'avalera un peu trop précipitamment.Ce poison est très dangereux voire mortel pour l'homme. Au Japon, on paye très cher le frisson : le traditionnel plat à base de Takifugu coûte un bras voire la vie s'il est mal préparé. Il faut des années pour apprendre à le faire. Quelques personnes meurent quand même chaque année… d'une erreur culinaire. Ce poison entraîne la paralysie du diaphragme, la victime ne peut plus respirer et s'étouffe.Parmi les célébrités bien connues des plongeurs, l'Arothron diadematus qui porte un masque noir, comme un Zorro obèse des récifs. Ou encore le Léonard de Vinci de la bande, le Torquigener albomaculosus ou Poisson-ballon bâtisseur. Il a été décrit seulement en 2014, après sa découverte au large du Japon. Son talent pour construire de sublimes rosaces sur le sable a fait de lui une star mondiale.Les mastodontes des Poissons-ballons sont les Arothrons. Tel que l'Arothron stellatus, le Poisson-ballon géant ou Poisson-ballon étoilé. Une “montgolfière” de 1,20m max de long, capable de vous sectionner un doigt avec son bec. Gnac !Dans la famille Ballon, il y a même un invasif, Lagocephalus sceleratus. Il colonise petit à petit la Méditerranée à cause du réchauffement. Originaire de la Mer Rouge, Sceleratus a traversé le canal de Suez (migration lessepsienne).À part les TétraodontiNés précédemment évoqués, l'autre sous-famille est celle des Canthigastérinés. Ces minis ultra choupis ne peuvent pas se gonfler d'eau mais sont tout aussi toxiques que leurs cousins. Vous connaissez l'un deux ! Puff, la vedette du film “Wonders of the reef” sorti en 2021 sur Netflix. Puff, ce bébé Poisson-ballon (Pufferfish en anglais) s'aventure dans la Grande Barrière de corail pour se trouver une maison. _______ 

I talk with Jody Vest of TTX on the ins and outs of interviewing, recruiting, and hiring for culture fit. Jody is very accomplished and humble. He has a great track record when it comes to hiring for culture. We discuss at length how he talks to candidates, and how he moves them through the hiring process successfully.

- Tăng trưởng xanh (TTX) với sự kết hợp hài hòa giữa phát triển kinh tế - xã hội và bảo vệ môi trường chính là tiền đề để thực hiện mục tiêu phát triển bền vững. Đây là cách tiếp cận mới trong tăng trưởng kinh tế, hướng tới sự phát triển hài hòa kinh tế - xã hội với phục hồi và bảo tồn hệ sinh thái tự nhiên. Từng bước chuyển dịch mô hình theo hướng TTX, những năm qua, Việt Nam đã đạt được một số kết quả tích cực, tuy nhiên, quá trình thực hiện cũng đang đặt ra không ít thách thức, đòi hỏi những giải pháp phù hợp. “Tăng trưởng xanh để phát triển xanh” – nội dung của chương trình Chuyển đổi xanh hôm nay. Chủ đề : tăng trưởng, xanh hóa, --- Support this podcast: https://podcasters.spotify.com/pod/show/vov1khcn/support

Do you need to go without food for a few days to understand hunger?Not drink for a day to feel extreme thirst?Not change clothes for a week to see whether merino wool will eventually stink?Probably not.So do you need to turn off the power at home to practice a power outage drill?Evacuate the home on short notice to see whether it will work?Welcome to the concept of Table Top Exercises.TTX are a cornerstone of efficient planning in the military and emergency services, recently adopted in the business continuity environmentThey excel when key individuals walk through a scenario, discussing what they would do, who they would employ and the timelines. There may be injects into the TTX to complicate the situation, however the value is having the key folks in the same location. Social capital, relationships and understanding the priority of other importance public agencies and corporate divisions.Support the Show.www.insidemycanoehead.ca

Episode 061- we cover a very productive and practical recruiting strategy with CEO Brandon Kenney of TTX.

Thanks to River for suggesting this week's topic, the pufferfish! Further reading: Grass puffer fish communicate with each other using a non-toxic version of their deadly toxin Mystery pufferfish create elaborate circular nests at mesophotic depths in Australia Pufferfish, puffed: A starry puffer, un-puffed [picture by Diego Delso, CC BY-SA 4.0, https://commons.wikimedia.org/w/index.php?curid=116912671]: A grass puffer, un-puffed: The mystery structure that turns out to be made by pufferfish: Show transcript: Welcome to Strange Animals Podcast. I'm your host, Kate Shaw. This week we're going to learn about a weird fish suggested by River, the pufferfish! Lots of fish have the name pufferfish, and sometimes they're also called balloonfish, swellfish, bubblefish, or globefish. You might be able to guess from the names what they can do, but just in case you don't know, the pufferfish can puff up to make itself big and round. The question you might have at this point is why, and how do they do this? There are lots of pufferfish in various genera, all of them in the family Tetradontidae. Tetradontidae means “four teeth,” because obviously when you find an incredibly poisonous fish that can blow itself up like a balloon, sometimes with spikes that emerge from the skin, of course you're going to name it after its teeth. Most pufferfish live in the ocean, although some live in places where freshwater mixes with ocean water, and some species even live in rivers. It prefers warm, shallow water and eats invertebrates and plant material. Larger pufferfish can use their four big front teeth to crush the shells of mollusks, like clams and mussels. Most pufferfish are quite small and often brightly colored with spots, stripes, and other markings. You'd think the biggest pufferfish has to be the one called the giant freshwater pufferfish, but while it is big, it's not the biggest. The giant freshwater pufferfish can grow up to 26 inches long, or 67 cm, which is over two feet long. But the starry puffer is almost twice that length, up to 47 inches long, or 120 cm. That's almost four feet long! The starry puffer lives in tropical and subtropical parts of the Pacific Ocean, especially in the Indian Ocean and the Red Sea. It has a big head, two pairs of nostrils, and is a mottled gray and white in color with little black spots all over. It mostly eats crustaceans and mollusks, but will also eat algae, sponges, coral, urchins, and other invertebrates. The pufferfish is a slow swimmer, but it has two really good defenses. If it feels threatened—for instance if a big fish tries to catch it, or it's caught in a fishing net and hauled to the surface, or if a diver tries to make friends, the pufferfish will swell up until it looks like a balloon with fins. It does so by gulping air or water into its elastic stomach until it's completely full. If you're wondering how this can help the fish, not only does this make the pufferfish look much larger, it also makes it harder to swallow. Not only that, the pufferfish has spines that may be hidden in the skin most of the time, but when the skin tightens as the fish expands into balloon shape, the spines poke out. Suddenly a potential predator isn't just trying to swallow a fish way bigger than its mouth is, it's pointy. The pufferfish's second defense is that its body contains a deadly poison. You may have heard about fugu, which is considered a delicacy even though it's so poisonous that in Japan and some other countries, chefs have to be specially trained and licensed to prepare the fish to eat. It contains tetrodotoxin, or TTX, a neurotoxin that stops your nerves from sending the tiny electrical signals that allow muscles to move. If you're poisoned with TTX, you start to feel dizzy and sick, then you start having difficulty speaking and moving, then you have trouble breathing, and then, ultimately, you're paralyzed and can't breathe,

While tabletop exercises (TTX) are considered a proven tool for finding gaps in an organization's security posture, they can be painstakingly challenging to plan and implement effectively. In a time where information security teams are understaffed and overworked, are TTX still worth the time and resources? Or are there other ways of ensuring incident response readiness? Navroop Mitter, the CEO of ArmorText, a mobile security and privacy startup, sheds light on the various aspects of tabletop exercises and their effectiveness as a preparedness tool.Time Stamps00:02 -- Introduction00:49 -- Setting the Stage and Compelling Stats02:48 -- Guest's Professional Highlights05:12 -- Overview of Tabletop Exercises07:15 -- Comparing Tabletop Exercises to Simulation11:12 -- Benefits of Running a Tabletop Exercise12:36 -- Table Top Exercise Resources15:18 -- Legal Representation in Tabletop Exercises 17:07 -- Doing Tabletop Exercises Right23:20 -- Mistakes To Be Avoided29:14 -- Building Resilient Communication Capabilities34:28 -- Final ThoughtsMemorable Navroop Mitter Quotes/Statements"A tabletop is a tool for organizations seeking to enhance their cyber resilience and readiness. It helps you develop muscle memory and identify gaps in your existing plans or other opportunities for enhancement.""Unfortunately, too often, tabletops are seen as something the cyber folks do alone in their dungeons. But they're just as essential for C-suite senior leadership and the board.""When we're helping organizations think through tabletops, or the simulations they're going to run, whether it's a very quick, lightweight discussion around the table, or a much more nuanced, immersive simulation, we're asking them to assemble stakeholders like senior leadership board members, IT and security teams, public relations, communications teams, legal counsel, human resources and finance together. This is not about the technologist. It's not just about security. This is about operational resilience. And that means the entire organization.""When you test your IR plan, even without having a formal team in place, just testing the IR plan alone was nearly as effective; you still had 48 days saved just by having rehearsed and tested your plan, just by having run the playbook before, and understanding what it was to be in that scenario, or something similar to it.""I think the need of the hour is increased executive and senior leadership involvement.""Done right, tabletops are actually there to help you prepare for managing regulatory litigation and reputational concerns that often follow these events."Connect with Host Dr. Dave Chatterjee and Subscribe to the PodcastPlease subscribe to the podcast so you don't miss any new episodes! And please leave the show a rating if you like what you hear. New episodes are released every two weeks. Connect with Dr. Chatterjee on these platforms: LinkedIn: https://www.linkedin.com/in/dchatte/ Website: https://dchatte.com/Cybersecurity Readiness Book: https://www.amazon.com/Cybersecurity-Readiness-Holistic-High-Performance-Approach/dp/1071837338

A show with mixes that have never been online before. Can be in all styles, most will be with vinyl. Got a bunch of old MiniDisks that I have to convert!! This time the first set I ever recorded on MiniDisc! Almost 23 years ago. Set never made it further than the MiniDisc I recorded it on. It's a Hard Trance and a really Early Hardstyle set. Well not all really Early Hardstyle but some of the records created the path to Hardstyle for me!! Also, the labels BXR, Nuklez and definitely Tracid Traxxx showed me a new style. As they continue to get harder and harder. The Harder Trance parts of the tracks became known as Hardstyle a few years later. At least this is my memory of how the musical journey went for me in those days. Hardcore was a bit fading out for me to play at that moment in time so I searched for a new style. And Hardstyle became it for me. Played these kind of records between 1998 and 2004 HAMdj - What Dreams May Come (12-05-2001) 01. Bismark - Make A Dream (Club Mix) [BXR 1102] 02. Mario Piu' Aka DJ Arabesque - The Vision (Vision 1 Mix) [BXR 1101] 03. Mauro Picotto - Iguana (Blank & Jones Remix) [BXRG 1078-12] 04. Embargo ! - Drums & Loops [CW021] 05. Mauro Picotto - Pegasus (Superclub Mix) [NUK P 0230] 06. Mario Piu' & Mauro Picotto - Spectra (Action Mix) [BXR 1059] 07. Nick Sentience & Mark Tyler - Wild Ride [NUK P 0222] 08. Pulsar & Friends - Biasca [PET 002] 09. K - Only The Strong [TTX 2002] 10. Master & Servant - Aurus (DJ Headhunter Mix) [none] 11. Zero-Gi - Dis [CW037] 12. Silent Breed - Sync-In [TTX 2004] 13. A*S*Y*S - Acid Save Your Soul (Auf Die 12 Mix) [TTX 2012] 14. Arrakis - The Spice [TTX 2007] 15. A*S*Y*S - DJ's Nightmare [TTX 2026] 16. Warmduscher 1 - Auf Die Fresse! [TTX 2010]

An arms race between newts and snakes means biological warfare.  Become a Patreon: https://www.patreon.com/herphighlights Merch: https://www.redbubble.com/people/herphighlights/shop Full reference list available here: http://www.herphighlights.podbean.com Main Paper References: Gilbert AL, Cabrera S, Hague MTJ, Stokes AN, Feldman CR, Hanifin CT, Brodie ED, Brodie ED. 2023. Phenotypic outcomes of predator–prey coevolution are predicted by landscape variation in climate and community composition. Functional Ecology 37:2170–2180. DOI: 10.1111/1365-2435.14360. Other Mentioned Papers/Studies: Calhoun, D. M., Bucciarelli, G. M., Kats, L. B., Zimmer, R. K., & Johnson, P. T. (2017). Noxious newts and their natural enemies: Experimental effects of tetrodotoxin exposure on trematode parasites and aquatic macroinvertebrates. Toxicon, 137, 120-127. Williams, B. L., Hanifin, C. T., Brodie, E. D., & Brodie III, E. D. (2010). Tetrodotoxin affects survival probability of rough-skinned newts (Taricha granulosa) faced with TTX-resistant garter snake predators (Thamnophis sirtalis). Chemoecology, 20, 285-290. Editing and Music: Podcast edited by Emmy – https://www.fiverr.com/emmyk10  Intro/outro – Treehouse by Ed Nelson Species Bi-week theme – Michael Timothy Other Music – The Passion HiFi, https://www.thepassionhifi.com

October is cybersecurity awareness month and recently the Resilience Think Tank hosted a free webinar on cyber resilience. This week's episode features the highlights of the webinar – and trust me, we brought in the big guns to talk about this important topic. Hello everyone and welcome to episode 106 of the Resilient Journey podcast, presented by the Resilience Think Tank. This week I'm joined by Michael Perdunn of Cyber Defense Labs, SSA Ken Schmutz of the FBI's Cyber Task Force and Warren Hagelstien from Cybersecurity & Infrastructure Security Agency. On this week's episode we talk about emerging threats, AI's impact on phishing, new SEC regulations, ransomware, the importance of educating employees and why small business are frequently targeted. We'll even provide you with some resources where you find more information and TTX scenarios.   Be sure to follow The Resilient Journey!  We sure do appreciate it! Learn more about the Resilience Think Tank here. Want to learn more about Mark? Click here or on LinkedIn or Twitter. Special thanks to Bensound for the music.

【本期嘉宾】SujiYan、刘锋、王嘉平SujiYan（Mask Network创始人）刘锋（链闻总编辑）王嘉平（前微软总部研究院研究主管）主播：潘乱（「乱翻书」主理人）【时间线】02:03 先从Token2049开始聊起，大家有啥参会体感？10:08 孙中山南洋博物馆，值得一去11:27 在淡马锡投资的TTX暴雷后，新加坡政府对web3是什么态度？17:02 香港在非常努力吸引Web3人才聚集，效果怎样？18:45 Web从业者，今天都分布在哪些城市？25:35 Crypto行业依然大家依然按照国籍、种族来互相抱团？27:36 如何看待华人在这个行业的状态？31:48 华人在矿业和交易所都有很大优势，为什么到了公链和DeFi时代弱势了？46:43 过去这两年这个行业大家都在忙啥？有在哪些方向取得了什么关键进展吗？59:26 「信不信不重要，信能挣钱能融资就好」62:35 两年后的老问题，Web3有什么产品是能够让普通人也用的？69:25 Web3验证了他的鲁棒性【开场&结尾音乐】开场&结尾音乐：Mount Dreams – Wolfs【相关推荐】1、 本节目第26期：加密、NFT和GameFi，为什么Web3会在此刻兴起？和第27期：Web3是补丁、革命，还是又一次农民起义？2、 本节目第34期：Web3归谁所有？来跟新世界VC聊一聊【关于「乱翻书」】「乱翻书」是一档关注商业、科技和互联网的从业者对话节目。关心How和Why，以及少有人注意到的What。内容主要方向是科技考古、行业观察和前沿思考，希望能够为你带来信息增量。「乱翻书」主理人是潘乱，代表作品有《腾讯没有梦想》、字节跳动/快手早期关键节点的系列特写。【关于主播】即刻/视频号/B站/抖音：潘乱公众号/播客：乱翻书左起：潘乱、SujiYan、王嘉平、刘锋微信公众号：乱翻书视频号：潘乱商业合作：联系微信 tongxing717本期编辑：怀杭

In this episode of the Business Broken to Smokin' Podcast: Lodestone True North's Head Coach Mark Whitmore and Joshua Pietrocini (VP of Operations at TTx https://www.ttx-inc.com/ ) continue their discussion about the book Predictably Irrational by Dan Ariely. 0:00 Intro 0:28 Why'd you pick up this book “Predictably Irrational” ? 4:10 Garden of Eden ideas 4:55 Our behavior is irrational, but it's predictable… 12:04 Why would you tell someone to read this book? 13:32 Book Reference - Jordon Peterson 12 Rules of Life 27:04 Expectations… 27:37 “The Matthew Principle” - Jordan Peterson 28:43 Pump The Brakes tool https://www.youtube.com/watch?v=ExqKYh4kzxM&t=0s 30:45 Procrastination groups from chapter 7 37:39 Guardrails in your life, like the bucket budget… 42:25 Money quote from chapter 4 45:10 Quote from the book Drive by Daniel Pink ** Credits** Music - Burning Down The House by Talking Heads Website: https://www.lodestonetruenorth.comWebsite: https://www.bigeasydesk.com (The best co-working space in Northeast Ohio!)LinkedIn Book Club Group: https://www.linkedin.com/groups/14158790/  LinkedIn Mark: https://www.linkedin.com/in/mark-whitmore-lodestone/LinkedIn Lodestone: https://www.linkedin.com/company/lodestone-true-northLodestone Online Courses: https://lodestone.thinkific.com Podcast:YouTube (video)https://youtube.com/@lodestonetruenorth Spotify (video or audio)https://open.spotify.com/show/3QCsZ7fyKr4z804oTac3FUApple Podcasts (audio)https://apple.co/3O4uv4H Other Podcast Platforms https://lodestonetruenorth.com/podcast/

In this episode of the Business Broken to Smokin' Podcast: Lodestone True North's Head Coach Mark Whitmore and Joshua Pietrocini (VP of Operations at TTx https://www.ttx-inc.com/ ) continue their discussion about project management, some personality assessments including Predictive Index and Culture Index, and a few things all of these type of assessments don't show or measure. 0:00 Intro 0:30 What are you looking for in a project manager? 11:25 Predictive Index assessment – https://www.predictiveindex.com/ 14:22 Culture Index – https://www.cultureindex.com - Links to David Quick interview episodes on Culture Index: - Episode 046: https://lodestonetruenorth.com/podcast-episode-046-interview-with-david-quick-part-1-of-2/ - Episode 047: https://lodestonetruenorth.com/podcast-episode-047-interview-with-david-quick-part-2-of-2/ 16:15 Book Reference – The Ideal Team Player by Patrick Lencioni 17:07 What these assessments don't show or measure… - Work ethic - Grit - Character - Value system - Chemistry - How someone handles pressure 33:20 Talk about the core values at TTx - People Focused - FILO – First In Last Out - Elite - All about the flag - Eyes wide open 42:39 “Act Your Wage” 46:32 “Restaurateur” – a person who owns and manages a restaurant. Book reference – Setting the Table by Danny Meyer “Business, like life, is all about how you make people feel. It's that simple, and it's that hard.” ― Danny Meyer 53:41 Shoutout to Brandon Kenney, CEO of TTx ** Credits** Music - Burning Down The House by Talking Heads Website: https://www.lodestonetruenorth.com Website: https://www.bigeasydesk.com (The best co-working space in Northeast Ohio!) LinkedIn Book Club Group: https://www.linkedin.com/groups/14158790/ LinkedIn Mark: https://www.linkedin.com/in/mark-whitmore-lodestone/ LinkedIn Lodestone: https://www.linkedin.com/company/lodestone-true-north Lodestone Online Courses: https://lodestone.thinkific.com Podcast: YouTube (video) https://youtube.com/@lodestonetruenorth Spotify (video or audio) https://open.spotify.com/show/3QCsZ7fyKr4z804oTac3FU Apple Podcasts (audio) https://apple.co/3O4uv4H Other Podcast Platforms https://lodestonetruenorth.com/podcast/

In this episode of the Business Broken to Smokin' Podcast: Lodestone True North's Head Coach Mark Whitmore and Joshua Pietrocini (VP of Operations at TTx https://www.ttx-inc.com/ ) discuss the book Predictably Irrational by Dan Ariely, and a lot about project management. 0:00 Intro5:19 Reference to Dune by Frank Herbert, audio book George Goodell reader https://hdaudiobooks.com/audiobook-dune/10:52 Reference to 6 Types of Working Genius by Patrick Lencioni and shoutout to Preston True14:27 A little bit of history about Joshua and his role at TTx…16:16 Struggling with Project Management…19:32 “You're managing timelines, expectations, tasks, schedules, communication, risks, creating . But you're leading people.”20:17 Kan Ban and reference to the book – 2 Second Lean by Paul Akers21:44 Talk about the different ways to organize Trello or Kan Ban28:44 Book reference – American Icon: Alan Mulally and the Fight to Save Ford Motor Company by Bryce G. Hoffman31:33 What would you recommend as resources for project managers? PMI Institute The 5 major phases of any project: Initiation Planning and discovery Execution Monitoring Closing 38:37 Different types of methodologies Waterfall Agile Scrum 44:19 (Freaking cool smoke ring!)49:59 AAR tool https://youtu.be/YScRIF5Pm-A54:26 “Latch” acronym used during an interview Loyal Available Teachable Coachable Hungry & Humble 56:16 Joshua's 5 desert island movies: Dances with wolves Magnolia Intouchables The beast of the southern wild Captain Fantastic (In the name of the Father, Daniel Day Lewis…) 1:07:52 Reference to Rick Beato https://www.youtube.com/@RickBeato Website: https://www.lodestonetruenorth.comWebsite: https://www.bigeasydesk.com (The best co-working space in Northeast Ohio!)LinkedIn Book Club Group: https://www.linkedin.com/groups/14158790/ LinkedIn Mark: https://www.linkedin.com/in/mark-whitmore-lodestone/LinkedIn Lodestone: https://www.linkedin.com/company/lodestone-true-northLodestone Online Courses: https://lodestone.thinkific.com Podcast: (Make sure you click on Subscribe so you don't miss any episodes!)YouTube (video)https://youtube.com/@lodestonetruenorthSpotify (video or audio)https://open.spotify.com/show/3QCsZ7fyKr4z804oTac3FUApple Podcasts (audio)https://apple.co/3O4uv4HOther Podcast Platformshttps://lodestonetruenorth.com/podcast/

Cet épisode est rediffusé exceptionnellement ici pour vous faire découvrir Petit Poisson deviendra Podcast (PPDP), le petit frère “aquatique” de Baleine sous Gravillon. Avec Combats et Nomen, ces podcasts forment "les 4 MousqueTERREs du Vivant". _______ Les Poissons-globes ou -ballons, au sourire si doux et au corps si gonflable, sont de sympathiques célébrités des récifs. Ils font partie de la famille des tétraodontidés. Ce nom vient du grec tetra-odon: “quatres dents”. En effet, ces poissons semblent avoir quatre énormes dents soudées, un peu comme des enfants. Cette famille donne son nom à l'ordre des tétraodontiformes de nos épisodes. Cet ordre rassemble pas mal de célébrités des océans : les Balistes (Triggerfish), les Molidés (Poisson-lune), les Diodons (Poissons porc-épic) et les Poissons coffres… Les Poisson-ballons vivent dans les récifs dans les eaux tropicales et subtropicales. Ils y mangent des algues, du zooplancton et des coquillages. Les Poissons-globes sont loin d'être des F1. Avec leur étrange sourire, ils seraient même plutôt très mouligasses. Mais pour se défendre, ils peuvent se gonfler en cas de danger. Ils avalent de l'eau très rapidement. C'est exactement le même principe que la Grenouille qui veut montrer qui c'est Raoul au Bœuf;) Dissuasif pour un éventuel prédateur. Une membrane derrière leurs dents leur permet de retenir cette eau dans leur estomac extensible. Les Poissons-globes sont ceinture ET bretelles. La plupart possède une autre arme mortelle : la tétrodotoxine (TTX), un poison plus ou moins foudroyant qui neutralise les organes vitaux de celui qui l'avalera un peu trop précipitamment. Ce poison est très dangereux voire mortel pour l'homme. Au Japon, on paye très cher le frisson : le traditionnel plat à base de Takifugu coûte un bras voire la vie s'il est mal préparé. Il faut des années pour apprendre à le faire. Quelques personnes meurent quand même chaque année… d'une erreur culinaire. Ce poison entraîne la paralysie du diaphragme, la victime ne peut plus respirer et s'étouffe. Parmi les célébrités bien connues des plongeurs, l'Arothron diadematus qui porte un masque noir, comme un Zorro obèse des récifs. Ou encore le Léonard de Vinci de la bande, le Torquigener albomaculosus ou Poisson-ballon bâtisseur. Il a été décrit seulement en 2014, après sa découverte au large du Japon. Son talent pour construire de sublimes rosaces sur le sable a fait de lui une star mondiale. Des vidéos de ce poisson ont fait des centaines de millions de vues sur YouTube.  Les mastodontes des Poissons-ballons sont les Arothrons. Tel que l'Arothron stellatus, le Poisson-ballon géant ou Poisson-ballon étoilé. Une “montgolfière” de 1,20m max de long, capable de vous sectionner un doigt avec son bec. Gnac ! Dans la famille Ballon, il y a même un invasif, Lagocephalus sceleratus. Il colonise petit à petit la Méditerranée à cause du réchauffement. Originaire de la Mer Rouge, Sceleratus a traversé le canal de Suez (migration lessepsienne). À part les TétraodontiNés précédemment évoqués, l'autre sous-famille est celle des Canthigastérinés. Ces minis ultra choupis ne peuvent pas se gonfler d'eau mais sont tout aussi toxiques que leurs cousins. Vous connaissez l'un deux ! Puff, la vedette du film “Wonders of the reef” sorti en 2021 sur Netflix. Puff, ce bébé Poisson-ballon (Pufferfish en anglais) s'aventure dans la Grande Barrière de corail pour se trouver une maison.  _______  

Link to bioRxiv paper: http://biorxiv.org/cgi/content/short/2023.04.14.536851v1?rss=1 Authors: Yuan, X., Puvogel, S., van Rhijn, J.-R., Esteve-Codina, A., Meijer, M., Rouschop, S., J.H. van Hugte, E., Oudakker, A., Schoenmaker, C., Schubert, D., Franke, B., Nadif Kasri, N. Abstract: Mechanisms that underlie homeostatic plasticity have been extensively investigated at single-cell levels in animal models, but are less well understood at the network level. Here, we used microelectrode arrays to characterize neuronal networks following induction of homeostatic plasticity in human induced pluripotent stem cell (hiPSC)-derived glutamatergic neurons co-cultured with rat astrocytes. Chronic suppression of neuronal activity through tetrodotoxin (TTX) elicited a time-dependent network re-arrangement. Increased expression of AMPA receptors and the elongation of axon initial segments were associated with increased network excitability following TTX treatment. Transcriptomic profiling of TTX-treated neurons revealed up-regulated genes related to extracellular matrix organization, while down-regulated genes related to cell communication; also astrocytic gene expression was found altered. Overall, our study shows that hiPSC-derived neuronal networks provide a reliable in vitro platform to measure and characterize homeostatic plasticity at network and single-cell level; this platform can be extended to investigate altered homeostatic plasticity in brain disorders. Copy rights belong to original authors. Visit the link for more info Podcast created by Paper Player, LLC

Link to bioRxiv paper: http://biorxiv.org/cgi/content/short/2023.03.30.534938v1?rss=1 Authors: Bedecarrats, A., Simmers, J., Nargeot, R. Abstract: Motivated behaviors such as feeding depend on the functional properties of decision neurons which provide the flexibility required for behavioral adaptation. Here, we analyzed the ionic basis of the endogenous membrane properties of an identified decision neuron (B63) that drive radula biting cycles underlying food-seeking behavior in Aplysia. Each spontaneous bite cycle arises from the irregular triggering of a plateau-like potential and resultant bursting by rhythmic subthreshold oscillations in B63's membrane potential. In isolated buccal ganglion preparations, and after synaptic isolation, the expression of B63's plateau potentials persisted after removal of extracellular calcium, but was completely suppressed in a TTX-containing bath solution, thereby indicating the contribution of a transmembrane Na+ influx. Potassium outward efflux through TEA- and calcium-sensitive channels was found to contribute to each plateau's active termination. This intrinsic plateauing capability, in contrast to B63's membrane potential oscillation, was blocked by the ICAN blocker flufenamic acid (FFA). Conversely, the SERCA blocker cyclopianozic acid (CPA), which abolished the neuron's oscillation, did not prevent the expression of experimentally evoked-plateau potentials. These results therefore indicate that the dynamic properties of the decision neuron B63 rely on two distinct mechanisms involving different sub-populations of ionic conductances. Copy rights belong to original authors. Visit the link for more info Podcast created by Paper Player, LLC

Les Poissons-globes ou -ballons, au sourire si doux et au corps si gonflable, sont de sympathiques célébrités des récifs. Ils font partie de la famille des tétraodontidés. Ce nom vient du grec tetra-odon: “quatres dents”. En effet, ces poissons semblent avoir quatre énormes dents soudées, un peu comme des enfants. Cette famille donne son nom à l'ordre des tétraodontiformes de nos épisodes. Cet ordre rassemble pas mal de célébrités des océans : les Balistes (Triggerfish), les Molidés (Poisson-lune), les Diodons (Poissons porc-épic) et les Poissons coffres… Les Poisson-ballons vivent dans les récifs dans les eaux tropicales et subtropicales. Ils y mangent des algues, du zooplancton et des coquillages. Les Poissons-globes sont loin d'être des F1. Avec leur étrange sourire, ils seraient même plutôt très droopy comme lascars. Mais pour se défendre, ils peuvent se gonfler en cas de danger. Ils avalent de l'eau très rapidement. C'est exactement le même principe que la Grenouille qui veut montrer qui c'est Raoul au Bœuf;) Dissuasif pour un éventuel prédateur. Une membrane derrière leurs dents leur permet de retenir cette eau dans leur estomac extensible. Les Poissons-globes sont ceinture ET bretelles. La plupart possède une autre arme mortelle : la tétrodotoxine (TTX), un poison plus ou moins foudroyant qui neutralise les organes vitaux de celui qui l'avalera un peu trop précipitamment. Ce poison est très dangereux voire mortel pour l'homme. Au Japon, on paye très cher le frisson : le traditionnel plat à base de Takifugu coûte un bras voire la vie s'il est mal préparé. Il faut des années pour apprendre à le faire. Quelques personnes meurent quand même chaque année… d'une erreur culinaire. Ce poison entraîne la paralysie du diaphragme, la victime ne peut plus respirer et s'étouffe. Parmi les célébrités bien connues des plongeurs, l'Arothron diadematus qui porte un masque noir, comme un Zorro obèse des récifs. Ou encore le Léonard de Vinci de la bande, le Torquigener albomaculosus ou Poisson-ballon bâtisseur. Il a été décrit seulement en 2014, après sa découverte au large du Japon. Son talent pour construire de sublimes rosaces sur le sable a fait de lui une star mondiale. Des vidéos de ce poisson ont fait des centaines de millions de vues sur YouTube.  Les mastodontes des Poissons-ballons sont les Arothrons. Tel que l'Arothron stellatus, le Poisson-ballon géant ou Poisson-ballon étoilé. Une “montgolfière” de 1,20m max de long, capable de vous sectionner un doigt avec son bec. Gnac ! Dans la famille Ballon, il y a même un invasif, Lagocephalus sceleratus. Il colonise petit à petit la Méditerranée à cause du réchauffement. Originaire de la Mer Rouge, Sceleratus a traversé le canal de Suez (migration lessepsienne). À part les TétraodontiNés précédemment évoqués, l'autre sous-famille est celle des Canthigastérinés. Ces minis ultra choupis ne peuvent pas se gonfler d'eau mais sont tout aussi toxiques que leurs cousins. Vous connaissez l'un deux ! Puff, la vedette du film “Wonders of the reef” sorti en 2021 sur Netflix. Puff, ce bébé Poisson-ballon (Pufferfish en anglais) s'aventure dans la Grande Barrière de corail pour se trouver une maison.  _______  

Les autres "dents de la mer" : Les Tétraodontiformes. Cet ordre regroupe des familles de poissons aux formes les plus étranges, les plus épineuses et les plus “gonflées” des océans.    Ces poissons ont des dents bien visibles. Leurs plaques dentaires du haut et du bas sont divisées en deux. Ils semblent avoir un grand sourire d'enfant ou de Fernandel laissant apparaître 4 dents géantes, il s'agit en réalité d'un assemblage de dents. De cette particularité, vient leur nom “tétraodontiforme”: en grec tetra signifie “quatre” et odon “dents”.   Les principales familles sont les :   Poissons-balistes (Balistidés)  Poissons-porc-épic ou Diodons (Diodontidés)  Poissons-lune (Molidés)  Poissons-lime, bourses ou Monacanthes (Monacanthidés)   Poissons-coffre (Ostracidés)  Poissons-globe ou ballons (Tétraodontidés)   L'ordre des Tétraodontiformes forme 10 familles et totalise 360 espèces. Certaines sont très connues des plongeurs. Nous dédions une mini-série de 7 épisodes à cet “ordre des étranges et des incroyables”.   Parmi les célébrités que vous découvrirez ces prochaines semaines :  Le Poisson-lune, Mola mola ou môle (Molidés), un gros mangeur de méduses, le plus lourd poisson osseux du monde, un géant dépourvu de queue qui nage en godillant. C'est le seul poisson connu à ce jour qui demande de l'aide aux oiseaux. Il leur offre son corps à la surface pour se faire retirer ses parasites.  Le Baliste (Balistidés) grogne, monte la garde, et va jusqu'à mordre pour protéger son nid. Baptisé triggerfish en anglais (Poisson gâchette). Il a deux dangereuses épines érectiles (dorsale et ventrale), qui sont aussi bien des armes que de grappins lui permettant de s'agripper aux rochers. Le Poisson-globe (Tétraodontidés) est un peu comme la grenouille qui voulait se faire plus grosse que le bœuf … Il gonfle son estomac d'eau pour impressionner ses prédateurs.  Les Diodons alias Poisson-porc-épic sont "ceinture et bretelles" : En plus de se gonfler d'eau, ils sont recouverts d'épines.  Le Poisson-coffre (Ostracidés) : Son corps est contenu dans un exosquelette (une sorte de boîte de section carrée). Il est très lent mais extrêmement manoeuvrant, son hydrodynamisme a inspiré les ingénieurs pour créer des Mercedes ou des robots aquatiques.  À part leur grosses dents d'enfant, ils ont d'autres capacités spécifiques en commun, que l'on retrouve dans les différentes familles.   Beaucoup de Tétraodontiformes sont toxiques. Nombre d'entre eux contiennent de la tétrodotoxine (TTX) dans leurs organes, une neurotoxine mortelle. Le plus célèbre en la matière est le célèbre Takifugu qui sert de base au Fugu, un plat très connu du Japon. Ceux qui le cuisinent doivent apprendre comment le préparer pendant 4 ans !  Beaucoup d'entre eux utilisent aussi des jets d'eau de façon habile: pour créer de magnifiques nids en forme de sculpture (Torquigener sp.) ou de mandalas tibétains dans le sable, ou pour retourner des oursins, déloger des petits vertébrés dans les coraux ou le sable. _______  

Episode 384 avec Benoît et Xavier.Sommaire :• B comme Banque (00:02:03) : La carte bancaire qui parle. La première carte bancaire qui chuchote à l'oreille des malvoyants. (source) • C comme ChatGPT (00:07:52) : Microsoft fait les yeux doux à OpenAI. Microsoft veut investir 10 milliard dans OpenAI. (source) • H comme Hapta (00:14:13) : Aide au maquillage. Les technologies haptiques au service de la beauté. (source) • I comme Immersion (00:19:37) : Aromajoin veut augmenter l'immersion. CES: Aromajoin propose le Aroma Shooter pour ajouter les odeurs à l'industrie des jeux vidéos et du cinéma. (source, source, source) • L comme Loi (00:27:02) : Cryptos: certains influenceurs bientôt au chômage en France? La France souhaite interdire aux influenceurs la promotion de cryptomonnaies. (source, source) • Q comme Qi2 (00:35:45) : MagSafe universel. Apple va ouvrir sa technologie MagSafe aux autres constructeurs. . (source, source) • T comme TTX (00:40:26) : VALL-E, une I.A meilleure qu'un imitateur. L'I.A. VALL-E imite sur base de 3 secondes de contenu. (source, source, source) • V comme Valencell (00:45:54) : Tensiomètre sans brassard. (source)

Therma-Tron-X, Inc is a leader in industrial finishing systems. As a sales engineer on the TTX team, Brian Rozdilsky spends his days solving his customers' oven problems. This requires industry knowledge, customer education, and a whole lot of creativity.

Link to bioRxiv paper: http://biorxiv.org/cgi/content/short/2022.09.07.506929v1?rss=1 Authors: Davy, O., Perrins, R., Lavigne, M., Kremer, E., Tsaneva-Atanasova, K., Ashby, M., Hirschberg, S., Pickering, A. E. Abstract: The Locus Coeruleus (LC) is the primary noradrenergic nucleus in the brain with widespread projections driving changes in cognitive state and animal behaviour. The LC is composed of multiple 'modules' with specific efferent target domains enabling discretional neuromodulation. LC neuronal activity releases noradrenaline within the nucleus as a local feedback mechanism, but it is not known how this influences modular output. We address this question using whole-cell recordings and calcium imaging in rat pontine slices in combination with LC neuronal ensemble modelling to assess the influence of local noradrenaline release on cross-modular interactions. Electrophysiological recordings of LC neurons from rats transduced with the optogenetic actuator ChR2 showed auto-inhibition and lateral inhibition (of surrounding non transduced neurons). This inhibition was strongly frequency dependent and was mediated by noradrenaline acting on alpha2-adrenceptors (alpha;2R). To allow calcium-imaging of LC neuronal ensembles a Canine-Adenoviral vector strategy was developed using the PRS promoter to drive selective expression GCaMP6s. Calcium imaging allowed resolution of both increases and decreases in LC activity (to TTX / clonidine or high potassium). Selective chemogenetic activation of subsets of LC neurons (expressing the ionotropic actuator PSAM) revealed both a direct excitation (after application of PSEM308, 3-PSEM308) and an alpha2R-mediated inhibition of neighbouring LC cells (non-transduced). Differential retrograde targeting of PSAM or GCaMP6s to specific LC modules showed the presence of strong, reciprocal cross-modular inhibition (shown for the LC-olfactory bulb vs LC bulbospinal modules) and a subsequent rebound activity inversion. This represents a preferential, targeted, cross-modular, lateral inhibition within the LC rather than a non-specific surround inhibition. Computational modelling showed the emergence of lateral inhibition and biphasic responses to modular activation when alpha2R signalling and noradrenergic reuptake saturation were included. This interaction may facilitate recruitment of neuronal ensembles by coherent inputs and represents a bottom-up differential contrast-enhancement mechanism within the LC to produce a modality specific focus. Copy rights belong to original authors. Visit the link for more info Podcast created by PaperPlayer

In this episode of the Business Broken to Smokin' Podcast, Lodestone True North's Head Coach Mark Whitmore continues the discussion of the book Team of Rivals with our guest Brandon Kenney, the CEO of TTX. Discussions also around family business, and generational transitions. 4:00 Book discussion, Team of Rivals by Doris Kearns Goodwin 17:22 Talking about family businesses and generational succession 56:00 Book reference, Radical Candor by Kim Scott 56:10 Book reference, Necessary Endings by Dr. Henry Cloud Website: www.lodestonetruenorth.com Website www.bigeasydesk.com LinkedIn Mark: https://www.linkedin.com/in/mark-whitmore-lodestone/ LinkedIn Lodestone: https://www.linkedin.com/company/lodestone-true-north Lodestone Online Courses: lodestone.thinkific.com Podcast: YouTube (video) https://www.youtube.com/channel/UCWcZ3wC733fQzTkWtAud0IQ Spotify (video or audio) https://open.spotify.com/show/3QCsZ7fyKr4z804oTac3FU Apple Podcasts (audio) https://apple.co/3O4uv4H **Credits** Music - The Finer Things by Steve Winwood Book - Team of Rivals by Doris Kearns Goodwin Book - Necessary Endings by Dr. Henry Cloud

In this episode of the Business Broken to Smokin' Podcast, Lodestone True North's Head Coach Mark Whitmore discusses the main premise from his upcoming book, The Visionary Dilemma. Website: www.lodestonetruenorth.com
 Website www.bigeasydesk.com LinkedIn Mark: https://www.linkedin.com/in/mark-whitmore-lodestone/ LinkedIn Lodestone: https://www.linkedin.com/company/lodestone-true-north
 Thinkific: lodestone.thinkific.com/ YouTube
 https://www.youtube.com/channel/UCWcZ3wC733fQzTkWtAud0IQ
 Spotify 
https://open.spotify.com/show/3QCsZ7fyKr4z804oTac3FU
 Apple Podcasts
 https://apple.co/3O4uv4H 2:42 Shoutout to TTX https://www.ttx-inc.com 4:00 What is vision? 5:46 Book referenced - Visioneering: Your Guide for Discovering and Maintaining Personal Vision, by Andy Stanley 6:00 Shoutout to Josh Gordon, Full Spectrum Marketing https://www.fsm.agency/ 17:35 The “Fair Weather” Canvas 19:35 Vision in relation to business 20:00 Back to Andy Stanley and Vision 21:20 John Adams mini-series https://www.imdb.com/title/tt0472027 26:25 Book referenced - The Real George Washington 33:50 What is vacation, anyways? 36:25 Brian Regan skit about station wagons 31:50 A Compelling vision comes from… 38:30 Talking about Mark's upcoming book, The Visionary Dilemma 38:45 Book referenced - The Survivors Club: The Secrets and Science that Could Save Your Life, by Ben Sherwood 42:50 Book referenced - Man's Search for Meaning, by Viktor Frankl 46:25 Book referenced - Drive, by Daniel Pink 4 7:20 M3M tool reference, link to other video 50:14 Joy and satisfaction comes from mastery 52:15 Reference to Stan Hywet & English gardens https://www.stanhywet.org/ 56:35 Shoutout to Apollo heating and cooling [link] 58:30 Back to casting a vision 59:28 The Visionary Dilemma - 3 Parts 1:00:00 First Dilemma - You're casting a vision for people that don't know they even need a vision… 1:01:45 - Without a vision people perish - Proverbs 1:04:14 - Adapting can be good, but we tend to have a toxic ability to adapt to something that we actually should change 1:04:30 Second Dilemma visions are invisible pictures 1:06:38 One of the goals of a visionary: putting clothes on the invisible man 1:08:48 Third Dilemma - Visions are disruptive **Credits** 2 Tickets to Paradise - Eddie Money Book - Man O Man, by Mark Whitmore

In this episode of the Business Broken to Smokin' Podcast, Brandon Kenney Co-Owner & CEO of TTx https://ttx-inc.com/ has a discussion with Lodestone True North's Head Coach Mark Whitmore over chapters 1-2 of the book “Team of Rivals: The Political Genius of Abraham Lincoln” by Dorris Kearns Goodwin. They also discuss the Culture, Strategic Niche, and Recruiting Flywheel of TTx. Brandon and TTx are one of those businesses that we are helping guide to the Land of Awesome.

In this episode, Senior Fellow Peter Garretson interviews Lieutenant General John E. Shaw, Deputy Commander of United States Space Command (USSPACECOM). They begin by explaining the role and responsibilities of USSPACECOM. They examine Gen. Shaw's new article, Sailing the Wine-Dark Sea: Space as a Military Area of Responsibilities (AOR), including its key propositions: the importance of Earth; the insufficiency of the term "global"; the need to re-imagine strategic terrain (upwell, downwell, cislunar); and the importance of the AOR to everyone. They detail the role of a COCOM in peace and in war. Next, they discuss the utility of a naval / maritime analogy for Spacepower, and the potential new missions. They touch on Gen. Shaw's book, Whither Space Power, and where it has proved prescient. They outline interagency challenges ahead such as rescue of space tourists and deflecting asteroids—including a recent NASA-FEMA-USSF-USSPACEOM tabletop exercise (TTX). Finally, they conclude with a vision of humanity's future in space if we play our cards right, and an invitation to young people to join the adventure through service in the United States Space Force. About Gen. John Shaw: https://www.spacecom.mil/Leaders/Bio/Article/2433977/lt-gen-john-e-shaw/ USSPACECOM: https://www.spacecom.mil/ Article: Sailing the Wine-Dark Sea https://www.airuniversity.af.edu/Portals/10/AEtherJournal/Journals/Volume-1_Issue-1/06-Shaw.pdf Book: Whither Space Power https://media.defense.gov/2017/May/05/2001742912/-1/-1/0/FP_0008_WORDEN_SHAW_WHITHER_SPACE_POWER.PDF USSPACECOM Posture Statement https://www.armed-services.senate.gov/imo/media/doc/USSPACECOM%20FY23%20Posture%20Statement%20SASC%20FINAL.pdf https://www.spacecom.mil/Testimony/ Planetary Defense TTX: https://www.jhuapl.edu/NewsStory/220310c-planetary-defense-exercise https://cneos.jpl.nasa.gov/pd/cs/ttx22/ Gen. Shaw Presenting on Planetary Defense at Space Symposium: https://www.dvidshub.net/image/7137185/usspacecom-deputy-presents-planetary-defense-37th-annual-space-symposium Gen. Shaw Wired Interview https://www.wired.com/story/space-commands-lt-gen-john-shaw-on-the-future-of-space-security/ Gen. Shaw OpEd https://spacenews.com/op-ed-the-u-s-space-force-must-be-independent-but-not-insular/

Having previously held a succession of finance leadership roles inside Chicago's ever vibrant financial services sector, Vicki Dudley was perhaps more surprised than anyone to find herself accepting a CFO position with Yancey Bros. Co. of Atlanta, the oldest Caterpillar dealer in the country.   Nevertheless, the job hop drew Dudley into a world of opportunity that she credits with having helped to open the door to her latest career chapter as CFO of TTX, the largest railcar provider in North America. “That particular experience did help to prepare me for my current role. Not only did we have sales for Caterpillar and Blue Bird bus, but also we had leasing plus repair facilities across the state of Georgia,” remarks Dudley, who gives credits to Yancey for tasking her with the company's process improvement function “and tying it to my toolkit.” –Jack Sweeney

This is a slightly edited version of the LinkedIn Live and YouTube Live show Dale Peterson recorded on March 17th. Dale begans talking about the Level 0 issue and was joined partway into the conversation by Ron Fabela. They talk about the awareness of insecure by design that exists in almost all Level 0 devices, the risk related to this, how asset owners are and should be looking at this, and more. Then the last ten minutes Dale talks about his two favorite Incident Response Tabletop Exercises and what you should expect when you do a TTX.

Podcast: Unsolicited Response Podcast (LS 30 · TOP 10% what is this?)Episode: Live Show: Level 0 Security & IR Table Top ExercisesPub date: 2021-03-18This is a slightly edited version of the LinkedIn Live and YouTube Live show Dale Peterson recorded on March 17th. Dale begans talking about the Level 0 issue and was joined partway into the conversation by Ron Fabela. They talk about the awareness of insecure by design that exists in almost all Level 0 devices, the risk related to this, how asset owners are and should be looking at this, and more. Then the last ten minutes Dale talks about his two favorite Incident Response Tabletop Exercises and what you should expect when you do a TTX.The podcast and artwork embedded on this page are from Dale Peterson: ICS Security Catalyst and S4 Conference Chair, which is the property of its owner and not affiliated with or endorsed by Listen Notes, Inc.

Organizational business continuity program should mandate CISO or CIO to have TTX periodically to rehearse the cyber security incident response plans. The level of participation and greater audience with variety of expertise to combat cyber security incidents quantify the TTX success. --- This episode is sponsored by · Anchor: The easiest way to make a podcast. https://anchor.fm/app --- Send in a voice message: https://anchor.fm/future-of-cybersecurity/message

While the COVID-19 crisis dealt a blow to retail and downtown apartment landlords, the industrial warehouse sector has seen a major boost this year due to a pandemic-induced rise in e-commerce and Amazon’s fast-growing expansion in Chicago. Reporter Alby Gallun joins the podcast to discuss. Plus: Illinois population drops for 7th straight year, the U.S. surgeon general praises Chicago's vaccine rollout, railcar company TTX keeps the downtown sublease train rolling and Pfizer has agreed to supply the U.S. with another 100 million doses of its vaccine.

Previous Election Security podcast: https://brakeingsecurity.com/2018-042-election-security-processes-in-the-state-of-ohio    Jeremy Mio (@cyborg00101)   https://itsecurity.cuyahogacounty.us/   Ohio Counties Meet LaRose's Deadline to Strengthen Election Security - Ohio Secretary of State (ohiosos.gov)  (added cybersecurity Directives during 2018 last podcast -jmio) Directive 2018-15 (6/21/18) - Cybersecurity  EI-ISAC Membership, DHS Services, IDS (Albert) Monitoring, Elections Infrastructure Security Assessment, Secure Online Services (DDoS Protection), examples via the State: Win10, DB Monderization, MFA, Cloud Email Pilot, IT Support Pilot Directive 2018-30 (9/28/18) - Reminder and Additional Clarifications   Einstein (US-CERT program) - Wikipedia Albert Program (added new cybersecurity Directives since last podcast  -jmio) Directive 2019-07 (5/06/19) - Specifics on security event reporting (expansion on 2017 Directive) Directive 2019-08 (6/11/19) - Expansion on 2018 and technical guides  Continuing 2018 requirements: EI-ISAC members, phishing tests, vulnerability scanning, continue to secure online systems (TLS/DDoS) Remediate all high priority findings from 2018 assessment by 1/31/2020 Additional technical requirements Additional DHS Services requested by 7/19/2019 (mitigate high findings by 1/31/20): Risk and Vulnerability assessment, Remote Pen Test, Arch Design Review, Cyber Threat Hunt Others: 2019 TTX, required all to use .US or .GOV domain, Annual assessments and background checks, Technical procurement guide, DMARC   LaRose issues directive to set a new standard for election security in 2020 (added -jmio) LaRose Announces Pick For Chief Information Security Officer Directive 2020-12 (7/14/20): Additional cybersecurity (and others) requirements by 8/28/2020 Cybersecurity Liaisons Extended IDS Albert funding and SIEM Services New: EDR and MDBR by 8/28/2020 (and additional push for DMARC) Securing Online Services and WAF, and requiring DHS Services Annually Vulnerability Management: Critical and High SLA Continue Annual cybersecurity training and background checks (including vendor/contractors), Physical Security Training Emergency Planning with local EMA and Sheriff    Vuln disclosure policy: Vulnerability Disclosure Policy - Ohio Secretary of State (ohiosos.gov) Did anyone think to pentest the vuln acceptance form? (lol, layers in layers --brbr)   8/11/20: LAROSE ISSUES FIRST IN THE NATION SECRETARY OF STATE VULNERABILITY DISCLOSURE POLICY (added -jmio)   DHS Vulnerability Disclosure Policy Directive Ohio to ramp up election security with new federal funds | TheHill “Ohio has taken steps to combat those types of threats. In October, Ohio Gov. Mike DeWine (R) signed into law a measure that required post-election audits to ensure the accuracy of the vote count, and created a “civilian cyber security reserve” to defend against potential cyberattacks. Directive 2020-12 - “Cybersecurity Liaisons” (added -jmio) LaRose says invitation to hackers will set new election security standard; expert says it's risky (wcpo.com) “His [secretary of state LaRose] first-of-its-kind Vulnerability Disclosure Policy invites Ohio’s crop of “white-hat” hackers — the good guys, opposite malevolent “black-hat” hackers — to break into the state’s election system, find bugs and report them so officials can ensure they’re fixed by Election Day. There are some strings attached: White hats aren’t allowed to phish for information or tamper with electronic county voter registration systems, and actual voting machines — legally barred from being connected to the internet — are off-limits. If they do find sensitive information, they’re expected to report it.” How did the threat model shift from the last time we talked? What has changed in terms of organization and threats? You mentioned 4-5 different voting regions last time, all with different levels of technology. Any updates on the tech?  How did covid change how voting occurred?  How have you leveraged the Elections Infrastructure ISAC (EI-ISAC) in passing along threats and sharing information? LAROSE TAKES ACTION IN RESPONSE TO IRANIAN CYBER THREATS (added -jmio) Has insider threat been part of your threat model and what has your group done to minimize the chances? (why does it feel like the Oscars has more scrutiny in terms of voting security than the US democratic process? --brbr) What does physical security look like in terms of people going to the polls? (wasn’t sure if that was something in your purview --brbr) (this is not (Election Board and Sheriff), but can discuss high level -jmio) Using hardware domain block services? Malicious Domain Blocking and Reporting (MDBR) Newest Service for U.S. SLTTs (cisecurity.org) LaRose Setting New Standard For Election Security - Ohio Secretary of State (ohiosos.gov) 88 election districts will have access to domain blocking tech (mandated to start by 28 August 2020), cybersecurity experts. Can you give us an update on any of what was mentioned in the press release Ohio's vulnerability disclosure program for elections indicates 'maturity' (added -jmio)   “LaRose in recent months has also implemented statewide use of endpoint detection monitoring software and required counties to develop contingency plans for any incident that disrupts the voting process.”   Background checks

Link to bioRxiv paper: http://biorxiv.org/cgi/content/short/2020.10.31.363341v1?rss=1 Authors: Martinez-Espinosa, P. L., Neely, A., Ding, J., Lingle, C. J. Abstract: Voltage-dependent sodium (Nav) current in adrenal chromaffin cells (CCs) is rapidly inactivating and TTX-sensitive. The fractional availability of CC Nav current has been implicated in regulation of action potential (AP) frequency and the occurrence of slow-wave burst firing. To ascertain whether features of CC Nav inactivation might influence AP firing, we recorded Nav current in rat CCs, primarily from adrenal medullary slices. A key feature of CC Nav current is that recovery from inactivation, even following brief (5 ms) inactivation steps, exhibits two exponential components of generally similar amplitude. Variations of standard paired pulse protocols support the view that entry into the fast and slower recovery processes result from largely independent, competing inactivation pathways, both of which occur with similar onset times at depolarizing potentials. Over voltages from -120 to -80 mV, faster recovery varies from ~3 to 30 ms, while slower recovery from about 50-400 ms. At strong activation voltages (+0 mV and more positive), the relative entry into slow or fast recovery pathways is similar and independent of voltage. Trains of brief inactivating steps result in cumulative increases in the slower recovery fraction. This supports idea that brief recovery intervals preferentially allow recovery of channels from fast recovery pathways, thereby increasing the fraction of channels in the slow recovery pathway with each subsequent inactivation step. This provides a mechanism whereby differential rates of recovery produce use-dependent accumulation in slower recovery pathways. Consistent with use-dependent accumulation of channels in slow recovery pathways, repetitive AP clamp waveforms at 1-10 Hz frequencies reduce Nav availability to 10-20% of initial amplitude dependent on holding potential. The results indicate that there are two distinct pathways of fast inactivation, one that leads to normal fast recovery and the other with a slower time course, which together are well-suited to mediate use-dependent changes in Nav availability. Copy rights belong to original authors. Visit the link for more info

Link to bioRxiv paper: http://biorxiv.org/cgi/content/short/2020.10.31.363416v1?rss=1 Authors: Martinez-Espinosa, P. L., Yang, C., Xia, X., Lingle, C. J. Abstract: Adrenal chromaffin cells (CCs) in rodents express a rapidly inactivating, TTX-sensitive sodium current. The current has generally been attributed to Nav1.7, although a possible role for Nav1.3 has also been suggested. Nav channels in rat CCs rapidly inactivate into two separable pathways, which differ in their time course of recovery from inactivation. One population recovers with time constants similar to traditional fast inactivation and the other about 10-fold slower. Inactivation properties suggest that the two pathways result from a single homogeneous population of channels. Here we probe the properties and molecular components of the Nav current present in mouse CCs. We first confirm that functional properties of Nav current in rat and mouse cells are generally similar in terms of activation range, steady-state inactivation, and dual pathway fast inactivation. The results then show that all inward Nav current is absent in CCs from Nav1.3 KO mice. Subsequently, in a mouse with KO of fibroblast growth factor homology factor 14 (FGF14), we find that the slow component of recovery from fast inactivation is completely absent in most CCs, with no change in the time constant of fast recovery. Experiments probing the use-dependence of Nav current diminution between WT and FGF14 KO mice directly demonstrate a role of slow recovery from inactivation in determination of Nav current availability. Overall, the results indicate that the FGF14-mediated inactivation is the major determinant in defining use-dependent changes in Nav availability in CCs. We also consider the potential impact that inactivating FGFs with different recovery kinetics can exert on differential use-dependent changes in Nav availability. Copy rights belong to original authors. Visit the link for more info

Popular culture would have you believe that TTX could be used to simulate death, even create zombies, but is this science fiction or fact?

Tim and Chris discuss the usefulness of cybersecurity TTX and how to keep the exercises fresh. Find out how to make the most of these simulations, who should be there, and how frequenly they should be performed.

Trish Dixon - VP of Cyber Operations at IronNet cybersecurity walks through the thoughts and tactics she used to secure her remote workforce when she was told to "Take everyone remote!" She shares resources on what your organization can do to better defend their home networks, and her #CollectiveCadence around how TTX's positively impacted her team. Reach out to Trish @ Linkedin.com/in/trishdixon

AAPEX, SEMA and AWDA is where all the latest Auto Parts are showcased. Andrew Rosen from Smyth Automotive traveled to Las Vegas for the shows. His stories of what happened in Vegas are not Staying In Vegas. Vendor Mention: Spectra Premium Parts and Mevotech TTX Off Road.

We are prouder than a mother with a new born to share our latest release artist, Pressure Point's cut from the last Sol Asylum Party at CDV. Pressure Point is distinguished by his productions and dj sets with a mixture of elaborated sounds complex groove compositions randomized fast-paced and a typically deep, melodic sound synthesis. His productions are enclosed for the large part composed of synthesizers, modular synth, sounds wonky and nano-loops all designed by sequencer step, triggers and creative impulses creating a harmonious unsteady gait. It's about micro-glitch music and house music futuristic well mixed and attention to the smallest detail. web.facebook.com/Pressurepoint.TTX/?ref=br_rs www.residentadvisor.net/dj/pressurepoint

Welcome to episode 15 of the TableTennisDaily podcast, today on the show we are joined alongside the Marketing Director of the ITTF, Steve Dainton.  Steve Dainton has had the role as the ITTF Markting director for the last 8 years helping grow and promote table tennis world wide. Steve has had an important role on developing the new revolution of table tennis known as TTX! What is TTX? Steve discusses on TTX and much more! 

Physical changes in neuronal connections, dictated by the neuronal network activity, are believed to be essential for learning and memory. Long-term potentiation (LTP) of synaptic transmission has emerged as a model to study activity-driven plasticity. The majority of excitatory contacts between neurons, called synapses, are found on spines, small dendritic protrusions. LTP is known to trigger the formation and stabilization of new dendritic spines in vitro. Similarly, experience-dependent plasticity in vivo is associated with changes in the number and stability of spines. However, to date, the contribution of excitatory synaptogenesis to the enhanced synaptic transmission after LTP remains elusive. Do new spines form functional synapses with the inputs stimulated during LTP induction and thereby follow Hebbian co-activation rules, or do they connect with random partners? Furthermore, at which time-point are de novo spines functionally integrated into the network? I developed an optical approach to stably and exclusively stimulate the axons of a defined channelrhodopsin-2 (ChR2)-transduced subset of CA3 cell in mature hippocampal slice culture over extended periods of time (up to 24h). I continuously monitored synaptic activation and synaptic structure of CA1 cells dendrites using two-photon imaging. To control the dendritic location where LTP and associated spinogenesis were allowed to take place, I globally blocked Na+-dependent action potential firing and directly evoke neurotransmitter release by local light-evoked depolarization of ChR2-expressing presynaptic boutons (in TTX, 4-AP). I induced optical LTP specifically at this location by combining optogenetic activation with chemical pairing (in low [Mg2+]o, high [Ca2+]o, forskolin, and rolipram). Taking advantage of the NMDA-receptor mediated calcium influx during synaptic activation I assessed the formation of functional synapses using the genetically encoded calcium indicator GCaMP6s. I find that optical LTP led to the generation of new spines, decreased the stability of preexisting spines and increased the stability of new spines. Under optical LTP conditions, a fraction of new spines responded to optical presynaptic stimulation within hours after formation. However, the occurrence of the first synaptic calcium response in de novo spines varied considerably, ranging from 8.5 min to 25 h. Most new spines became responsive within 4 h (1.2 ± 0.9 h, mean ± S.D., n = 16 out of 20), whereas the remainder showed their first response only on the second experimental day (18.2 ± 3.7 h). Importantly, new spines generated under optical LTP were more likely to build functional synapses with light-activated, ChR2-expressing axons than spontaneously formed spines (new responsive spines under optical LTP: 64 ± 4 %; control 1: 0%; control 2: 13 ± 4 %; control 3: 11 ± 4 %). Furthermore, new spines that were responsive to optical presynaptic stimulation were less prone to be eliminated after overnight incubation than new spines that failed to respond (% overnight spine survival; 81 ± 3 % new responsive spines; 58 ± 4 % of new unresponsive spines). In summary, the results from my thesis demonstrate that synapses can form rapidly in an input-specific manner.

Jonatan Schumacher Director of CORE Studio at Thornten Tomasetti drops by the Designalyze studio for this episode. We talk Arduino, TTX, Github, JIRA, Three.js, AEC Hackathon, and Jonatan's 23 minute commute to work. SHOW NOTES. On Designalyze, we analyze what makes thought leaders in design technology tick through informative, insightful, and often humorous interviews. Designalyze is hosted by Zach Downey and Brian Ringley and recorded in DUMBO, Brooklyn. For design technology tutorials and content visit us at http://designalyze.com

El primer podcast dedicado al mundo de la moto en Castellano

1. Adult rats and rats with a postnatal age of 3-29 days (PN 3-29) were used for the preparation of in vitro slices of the frontal neocortex. Epileptiform activity was induced by bath application of the gamma-aminobutyric acid-A (GABAA) receptor antagonists bicuculline or picrotoxin. 2. The voltage-sensitive dye RH 414 and a laser scanning microscope were used for multiple-site optical recordings of membrane potential changes associated with epileptiform activity. Optical signals were compared with simultaneously measured extra-cellular field potentials. 3. Optical signals could be reliably recorded for the duration of the experiments (2-4 h). Extracellular recordings of convulsant-induced paroxysmal depolarizing shifts (PDSs) in slices stained with RH 414 were comparable with those obtained in unstained slices. Changes in dye signals in response to reductions in extracellular calcium, addition of tetrodotoxin (TTX), or application of excitatory amino acid receptor antagonists indicate that the fluorescence changes correlate well with established electrophysiological measures of epileptiform activity. 4. In slices from adult animals, dye signals were observed at all recording sites. The response with the shortest latency occurred invariably at the site of stimulation, and activity spread rapidly in both vertical and horizontal directions. Spread was significantly faster in the vertical than in the horizontal direction. 5. Epileptiform activity was absent or only weakly expressed in slices from PN 3-9 animals. Activity was detectable predominantly in upper cortical layers. 6. Dye signals were observed at all measurement points in slices from PN 10-19 animals. In this age group, peak amplitude increased with spread of activity from lower to upper cortical layers. There was no significant difference between the speed of propagation in the vertical and in the horizontal directions. Spontaneous epileptiform activity occurred at a high rate in the PN 10-19 age group, and signals associated with spontaneous epileptiform events were largest in upper layers. 7. In the PN 10-19 age group, optical signals were characterized by the repetitive occurrence of PDS discharges superimposed on a sustained response. The amplitude of the sustained response decreased with increasing distance from the site of stimulation. Analysis of the latencies revealed that the superimposed PDS-like events were generated at multiple sites within the scanning area. Amplitude and rate of rise were largest in slices from PN 10-19 animals. These values declined with ongoing development.

The effect of low concentrations of barium on the membrane properties of rat neocortical neurons was studied in vitro. Potassium currents were examined using single-electrode current- and voltage-clamp techniques. Neurons responded to bath application of barium (10–100 μM) with a membrane depolarization associated with an increase in input resistance. Under voltage clamp conditions, an inward shift in holding current was observed. The effects of barium were rapidly reversible upon washing and persisted in the presence of TTX. The equilibrium potential for the barium-induced inward current was near −110 mV, suggesting that barium inhibited a tonically active potassium conductance. Measurements of current voltage relationships indicated an inward rectification of this conductance between −50 and −130 mV. These results provide strong evidence that barium blocks a persistent potassium ‘leak’ current in neocortical neurons that contributes to the resting potential of these cells.

1. The nature, distribution and function of rectifying channels in rat spinal root myelinated axons has been assessed with selective blocking agents and a variety of intracellular and extracellular recording techniques. 2. The electrotonic responses of roots poisoned with tetrodotoxin (TTX) to constant current pulses had fast (rise time much less than 1 ms) and slow components, which were interpreted in terms of Barrett & Barrett's (1982) revised cable model for myelinated nerve. Depolarization evoked a rapid outward rectification (time constant, tau approximately 0.5 ms), selectively blocked by 4-aminopyridine (4AP, 1 mM), and a slow outward rectification (tau approximately 15 ms), selectively blocked by tetraethylammonium (TEA, 1 mM) or Ba2+ (0.5 mM). Hyperpolarization evoked an even slower inward rectification, selectively blocked by Cs+ (3 mM) but not by Ba2+. 3. From the different effects of the blocking agents on the fast and slow components of electrotonus, it was deduced (a) that the inward rectification is a property of the internodal axon, (b) that the slow outward rectifier is present at the nodes, and probably the internodes as well, and (c) that the 4AP-sensitive channels have a minor nodal and a major internodal representation. 4. TEA and Ba2+ reduced the accommodation of roots and fibres not poisoned with TTX to long current pulses, whereas 4AP facilitated short bursts of impulses in response to a single brief stimulus. 5. TEA and Ba2+ also abolished a late hyperpolarizing after-potential (peaking at 20-80 ms), while 4AP enhanced the depolarizing after-potential in normal fibres, and abolished an early hyperpolarizing after-potential (peaking at 1-3 ms) in depolarized fibres. Corresponding to the later after-potentials were post-spike changes in excitability and conduction velocity, which were affected similarly by the blocking agents. Cs+ increased the post-tetanic depression attributable to electrogenic hyperpolarization. 6. The physiological roles of the three different rectifying conductances are discussed. It is also argued that the prominent ohmic 'leak conductance', usually ascribed to the nodal axon, must arise in an extracellular pathway in series with the rectifying internodal axon.