Podcasts about faecal

Faecal transplant, also known as faecal microbiota transplantation or FMT, is the transfer of stool from a healthy donor to a patient with a disease. The idea is to restore the balance of bacteria in the gut, which can be disrupted by factors such as antibiotics, diet, or infection but it could potentially help with a range of problems from irritable bowel syndrome to Alzheimer's.  Why is faecal transplant used? How does faecal transplant work? How is faecal transplant performed? What are the risks of faecal transplant? In under 3 minutes, we answer your questions! To listen to the last episodes, you can click here: Could Britain ever rejoin the EU? What 5 foods can improve brain performance? What is pandemic skip? A podcast written and realised by Joseph Chance. First broadcast: 10/8/2023 Learn more about your ad choices. Visit megaphone.fm/adchoices

A Cold Open, Sausage Haggling, Neil Discovers The Map Exists Again, An Old Lady Gets Bullied, Bish Bash Bosh, We Are Dropping At Tilted Towers, Its Star Of Stage And Screen Jack Lyttle With Some Thrilling Exposition, Noughts And Ogres, A Stat Check and much much more!Bluesky:https://bsky.app/profile/dungeonsanddheads.bsky.socialInstagram:https://www.instagram.com/dungeonsanddheads/Discord:https://discord.gg/brB2Agj65VPatreon:https://www.patreon.com/c/DungeonsAndDHeadsYouTube:https://www.youtube.com/@DungeonsAndDheads Hosted on Acast. See acast.com/privacy for more information.

This week is hosted by Philippa & QuentinWe talk about what has happened in Ambridge, in The Archers so far this weekA short midweek round up of The Archers SO FAR focusing on Sunday, Monday & Tuesday episodes up to 11/2/25.Join us for our LIVE online PATREON event: https://www.patreon.com/AllAboutTheArchersOr you can BUY US A COFFEE here: buymeacoffee.com/allaboutthearchersYou can buy our MERCH here: https://www.redbubble.com/people/aboutthearchers/shopDo join our FACEBOOK Group: https://www.facebook.com/groups/1127587031446013/ You can also watch this on YOUTUBE: https://www.youtube.com/@AllAboutTheArchers-vv8jz/videosThe ArchersWe are on BLUESEKY!: https://bsky.app/profile/allaboutthearchers.bsky.socialAmbridgeBBCRadio4#Brookfield #TheArchers #AllAboutTheArchers #radio4 #bbcradio #bbcradio4 #ambridge #soapopera #borchester #bridgefarm #podcast Hosted on Acast. See acast.com/privacy for more information.

In this episode of the UEG Talks conversation between Maria Vehreschild and Pradeep Mundre, we delve into the complexities of the faecal microbiome and the role of faecal microbiota transplantation (FMT) in treating various diseases, particularly C. difficile infections and inflammatory bowel disease (IBD). The discussion covers the historical context of FMT, its mechanisms of action, current treatment guidelines, safety considerations, and the various delivery methods. The conversation also emphasises the need for further research and the importance of professional standards in FMT practices.

In this episode, Jonathan Sackier sits down with David Wan to discuss the latest advances in colorectal cancer screening, the importance of high-quality colonoscopy, and the emerging role of AI in polyp detection.    Timestamps:     (00:00)-Introduction  (01:45)-Linking neuroscience and gastroenterology  (05:16)-The role of the microbiome in disease (7:44)-Unusual clinical cases (13:52)-Colorectal cancer screening (21:47)-Virtual colonoscopy (23:03)-Faecal calprotectin (25:11)-How to ensure a high-quality colonoscopy? (30:36)-Inpatient gastrointestinal care (34:47)-Variceal bleeding (36:30)-New horizons in gastroenterology (39:53)-Wan's three wishes for healthcare

Jack welcomes Ricky back to the show to talk about the state of Spurs right now. Faecal burgling analogies contained within. Support this show http://supporter.acast.com/ruletheroost. Hosted on Acast. See acast.com/privacy for more information.

Get access to our clinical podcast series with our ⁠⁠30% off IVECCS Special.⁠⁠ Get case support from our team at specialists in our ⁠⁠⁠⁠Specialist Support Space⁠⁠⁠⁠. Does anyone else feel a bit powerless in those acute diarrhoea consults since we've learned that we shouldn't give metronidazole? Your client has come to you for a solution, and you want to help, but there's nothing you can give them that will really help that much. Or is there? Our bonus episode for day three of our IVECCS 2024 highlights series might give you that magic pill you've been looking for… poop! Dr. James Oldeschulte is well-acquainted with treating acute diarrhoea as an experienced ER vet, and in this conversation, he shares some freshly published data that highlights the efficacy and clarifies the practicalities of using psyllium fibre and faecal transplants in the treatment of acute diarrhoea in veterinary patients. Sign up for our ⁠⁠free weekly newsletter⁠⁠ to hear about my favourite 3 lessons I learnt in that week from making the podcasts.

Send us a Text Message.Following on from the last episode of the podcast, as promised this is part 2 with Rachel Jessey from Benourised. We continue and expand on the short conversation we had at the end of the last episode on faecal implant, Rachel has so much knowledge and this is a really interesting topic. We also talk about the circadian rhythm and how we can reset this rhythm which supports the natural absorption of vitamin D, sleep, digestion and more. I explain what I put into practice during my recent holiday and what the impact this has had , listen to this episode of the podcast to find out more. Rachel talks about the benefit of natural light thinking about the full spectrum of light, sunrise and sunset. Rachel and I talk about the different severities of chronic conditions and how we can support and meet patients where they are in their journey, and what benefits this can have. We touch upon the benefit of red light and will have a part 3 to this podcast to discuss this in more detail. This is another podcast filled with lots of information, I really appreciate Rachel joining me. As always thank you for listening to the podcast #onedayatatime Links from this episode: Rachel's details: https://www.benourisehed.co.uk/Email:rachel@benourished.co.ukJack Ruse https://jackkruse.com/Alexander Marakovsky https://www.longdom.org/open-access/the-industry-originated-probiotic-bacteria-role-in-covid19-60345.htmlDocumentary: Hack Your Health: The Secrets of Your Gut https://www.netflix.com/title/81436688 My Links:Long Covid clinic -Dr Binita Kane & Julie Taylor; Email: info@thelongcovidclinic.co.uk for more information Linktree:https://linktr.ee/joulestXhttps://twitter.com/julieTa58407536Facebook page:https://www.facebook.com/livingwithlongcovid/Instagram:https://www.instagram.com/julie_livingwithlongcovidPlanners:https://amzn.eu/d/9v9MP4vReturn to work planner:https://amzn.eu/d/1QVK8zn Well being planner:https://amzn.eu/d/a1Safxc

Join The Kernels as they dive into Doug Liman's 2024 burly bouncer reboot: 'Road House.Revelling in remakes, name nomenclature, and coffee shop carnage - The Kernels share their likes, dislikes, ratings & even treat you to an original song, AND a unique game where they create a movie trailer. Enjoy you buoyant bouncers!Thanks for popping by. We hope you enjoy The Podcorn Kernel Podcast. Please get in touch with any praise, criticism, feedback or advice.Compliments will be greeted with kindness. Criticism will be catered to with carnage. Contact us at : thepodcornkernels@gmail.com or find us on us on the following social platforms:Instagram: thepodcornkernelsThreads: thepodcornkernelsTwitter: @podcornkernelsWebsite: thepodcornkernels.co.ukTikTok: @thepodcornkernels

In his weekly clinical update, Dr. Griffin discusses RSV vaccination recommendations and revisions to guidelines before reviewing the recent statistics on SARS-CoV-2 infection, data suggesting that individuals with high HLA-DQA2 expression (MHC class II) are better at preventing the onset of a sustained viral infection, how moderate coffee intake can reduce risk of COVID-19 severity but cannabis use resulted in more severe disease but reduced risk of mortality, where to find PEMGARDA, if statin use prevented severe COVID-19, the benefit of administering nirmatrelvir and ritonavir after 5 days, convalescent plasma, what do when healthcare workers succumb to SARS-CoV-2 infection, if fecal microbiota transplants aid in recovery from COVID-19, and the definition of characteristics and clinical patterns for the diagnosis of long COVID. Subscribe (free): Apple Podcasts, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode CDC ACIP for RSV (CDC) This respiratory virus season everyone age 75 and older receive the RSV vaccine (CDC Newsroom) Revised RSV vaccine recommendations (CIDRAP) COVID-19 national trend (CDC) COVID-19 deaths (CDC) Local and systemic response dynamics to SARS-CoV-2 infection (Nature) Drink more coffee, reduces risk for SARS-C0V-2 infection (Cell & Bioscience) Cannabis, tobacco…smoking in general NOT good for preventing COVID-19 (JAMA Network OPEN) Do older versions of the COVID-19 vaccine still provide any protection (JAMA Internal Medicine) Where to get pemgarda (Pemgarda) CDC Quarantine guidelines (CDC) Early phase of SARs-CoV-2 infection (COVID.gov) NIH COVID-19 treatment guidelines (NIH) Infectious Disease Society guidelines for treatment and management (ID Society) Adjuvant statin therapy reduces SARS-CoV-2 mortality (American Journal of Medicine) Nirmatrelvir and ritonavir beyond 5 days of symptom onset improved the multiple organ dysfunction in severe COVID-19 patient (BMC Infectious Disease) Molnupiravir safety and efficacy (JMV) Convalescent plasma recommendation for immunocompromised (ID Society) What do when your heathcare provider is infected with SARS-CoV-2 (CDC) Managing healthcare staffing shortages (CDC) Steroids, dexamethasone at the right time (OFID) Anticoagulation guidelines (hematology.org) Faecal microbtiota transplantation cures sleep disturbance in post-acute COVID-19 syndrome (Clinical Gastroenterology and Hepatology) Long COVID defined by patient phenotype (CIDRAP) Three distinct symptom-based post-COVID condition phenotypes (JID) Contribute to our Floating Doctors fundraiser Letters read on TWiV 1126 Dr. Griffin's COVID treatment summary (pdf) Timestamps by Jolene. Thanks! Intro music is by Ronald Jenkees Send your questions for Dr. Griffin to daniel@microbe.tv

Dr Philip Smith, Digital and Education Editor of Gut and Honorary Consultant Gastroenterologist at the Royal Liverpool Hospital, Liverpool, UK interviews Dr Kurtis Budden, from the Immune Health Program, The University of Newcastle and Hunter Medical Research Institute, Newcastle, NSW, Australia and Professor Philip Hansbro who is also a conjoint there and the Director of the Centenary Institute and University of Technology Sydney Centre for Inflammation, Sydney, NSW, Australia, on the paper "Faecal microbial transfer and complex carbohydrates mediate protection against COPD" published in paper copy in Gut in May 2024. Please subscribe to the Gut podcast on your favourite platform to get the latest podcast every month. If you enjoy our podcast, you can leave us a review or a comment on Apple Podcasts (https://apple.co/3UOTwqS) or Spotify (https://spoti.fi/3Ifxq9p). 

Text Dr. Black your questions or comments.In episode 11 of Eat Your Greens with Dr. Black, listeners head to college to learn about the microbiome and its vital role in maintaining overall health. Dr. Black is joined by Dr. Micaela Vargas from the Department of Biology at Texas State University, and they discuss the complex and fascinating aspects of the microorganisms that live in our bodies, particularly our gut. The extensive effects of a healthy microbiome are outlined, from helping to prevent serious diseases like heart disease and cancer, to aiding digestion, regulating blood sugar, and potentially slowing aging. Listen in as Dr. Black and Dr. Vargas explore the impact of lifestyle factors such as diet, sleep, and exercise on the gut microbiome. The episode concludes with practical tips on how to nurture and support a healthy microbiome.Recipe for Dr. Black's breakfast smoothieConnect with Dr. Vargas: https://www.linkedin.com/in/micaelavargasphd/ Links to research articles The Human Microbiome Project Reaches Conclusion The origins of gut microbiome research in Europe: From Escherich to Nissle Current understanding of the human microbiome Association between antibiotics and gut microbiome dysbiosis in children: systematic review and meta-analysis Specific gut microbiome signatures and the associated pro-inflamatory functions are linked to pediatric allergy and acquisition of immune tolerance Faecal microbiota transplantation halts progression of human new-onset type 1 diabetes in a randomised controlled trial Short-Chain Fatty-Acid-Producing Bacteria: Key Components of the Human Gut Microbiota Gut Microbiota: An Important Link between Western Diet and Chronic Diseases Anticancer EffectsIf you enjoyed this episode, please take a moment to rate it, leave a review, and most importantly, share it with a friend! For my free guide to Living a Plant-Forward Life, visit the show website and subscribe! eatgreenswithdrblack.com For resources related to a plant-based diet or if you struggle to afford healthy food for your family, please go to eatgreenswithdrblack.com/resources.You can contact Dr. Black at dr.black@eatgreenswithdrblack.comI am happy to answer general questions related to the information presented on this podcast. Be advised that I will never offer specific medical advice via this website, even if your child is an established patient in my practice. If you have concerns about your child's health or growth, please contact their doctor.Thanks for listening and don't forget to Eat Your Greens!

A fundamental basic of ruminant nutrition – energy density of feeds – is covered in this latest Rumen Room Podcast. Expressed as Megajoules of Metabolisable Energy per kilogram of dry matter (MJME/kgDM), energy density is an important driver of animal productivity and profitability. In a down to earth, practical “gumboot level” manner, Dr Charlotte Westwood explores the basics of MJME as a concept and covers how feed testing laboratories measure MJME. How we use MJME values of a feed on farm on a day to day basis is explained. The strengths and possible limitations with the use of MJME in our day to day farm-level decisions is discussed. Don't be put off by what is often thought to be a rather "dry" topic of MJME - actually, it's a straightforward concept - we're sure you'll learn a lot from this latest podcast! Here's where to find the various sections within the MJME podcast, below: 2.02 Outline of this MJME podcast 3.40 What is “energy”? 6.30 Defining Megajoules and Metabolisable Energy 7.50 Megajoules compared to Megacalories – what's the difference? 10.25 What is gross energy and why might we be interested? 14.25 Why ruminants can't use all of gross energy in feeds for useful things 15.10 Faecal energy – what a waste! (#1) 16.10 Digestible energy 17.25 Methane – what a waste! (#2) 18.10 Finally arriving at the MJME number…. How this is calculated 19.00 How different feeds change energy losses as methane 21.00 Measuring MJME – inside the sheep 23.00 Feed testing laboratories estimates of MJME 25.40 Using the digestibility value to calculate MJME 26.20 NIRS technology - digestibility and MJME 31.15 Strengths and weaknesses of MJME as a measure of feed quality – an overview 32.00 Typical MJME values of feed 34.40 Valuing our feeds on a cents per MJME basis – a simple task on farm! Valuing a bale of pasture baleage on an MJME basis as an example 38.00 Using MJME as part of your feed budgeting – MJME demand vs. MJME supply. A 30kg liveweight lamb as an example 40.30 Limitations of MJME as an indicator of suitability of a feed for animals 41.30 MJME is a calculated measure only! 42.00 MJME doesn't tell us about all of the other interesting stuff in feeds 44.10 Summing up the MJME topic

Colorectal cancer is the fourth most common type of cancer in the UK, with over 40,000 new cases each year. The positive predictive value of Faecal immunochemical testing (FIT) far exceeds that of symptoms and makes FIT an important tool for triaging patients with symptoms suggestive of colorectal cancer to the right diagnostic pathway. In this podcast Dr Thomas Round, a GP and EKU Clinical Lead, talks to Dr Kevin Barrett, a GP in Hertfordshire with a special interest in gastroenterology, about faecal immunochemical testing in patients with signs or symptoms of suspected colorectal cancer (CRC)

Faecal transplant, also known as faecal microbiota transplantation or FMT, is the transfer of stool from a healthy donor to a patient with a disease. The idea is to restore the balance of bacteria in the gut, which can be disrupted by factors such as antibiotics, diet, or infection but it could potentially help with a range of problems from irritable bowel syndrome to Alzheimer's.  Why is faecal transplant used? How does faecal transplant work? How is faecal transplant performed? What are the risks of faecal transplant? In under 3 minutes, we answer your questions! To listen to the last episodes, you can click here: Could Britain ever rejoin the EU? What 5 foods can improve brain performance? What is pandemic skip? A podcast written and realised by Joseph Chance. In partnership with upday UK. First broadcast: 10/08/2023 Learn more about your ad choices. Visit megaphone.fm/adchoices

Welcome to another podcast exploring management of bowel dysfunction!   Alison Hainsworth asks a panel of experts  -  Julie Cornish, Liliana Bordeianou and Emily Hoile - to help us to understand how we can look after our patients with faecal incontinence. We look at treatments - ranging from conservative measures to surgical intervention. We aim to offer practical advice as to how we can best serve our patients!  Registration for ICS 2023 Toronto is now open at www.ics.org/2023/register The ICS annual meeting is the must-attend, multidisciplinary event for clinical and research scientists interested in: Urology Urogynaecology Female and functional urology Gynaecology Bowel dysfunction Neurourology Pure and applied science Physiotherapy Nursing Geriatrics The ICS 2023 Toronto conference fosters collaboration between all disciplines involved in continence care.

Faecal incontinence affects one in 25 women in postpartum and today, Claire shares her experience. She takes us briefly through her labour and birth and details the confronting realisation that she had no control of her anal sphincter. Thanks to a women's health physiotherapist who demanded horizontal rest - essential for all new mothers! - pelvic floor exercises and dietary changes, Claire recovered by six weeks. She emphasises how important it is to share her story because she had never heard of it happening before and wondered if it was her new reality; a challenging prospect at a very vulnerable time. See omnystudio.com/listener for privacy information.

In this episode, we talk to Mr James Bailey, a Colorectal Research Fellow from the Nottingham Colorectal Service. Paper: Sociodemographic Variations in the Uptake of Faecal Immunochemical Tests in Primary CareAvailable at: https://doi.org/10.3399/BJGP.2023.0033FIT is increasingly used to triage patients with symptoms suggestive of colorectal cancer but variations in use by demographics, ethnicity and socioeconomic status are unknown. We show, in a large regional dataset, that male patients, patients under 65 years, the most deprived patients and ethnic minority groups are less likely to return a FIT sample. It is important that strategies are developed to ensure patients with these protected characteristics are not disadvantaged with the increasing usage of FIT to prioritise urgency of investigations.

For more information on SCOPS visit www.scops.org.ukFor our podcast disclaimer see here - scops.org.uk/podcasts/Today on the podcast we're talking about practical options for performing wormer treatment checks and faecal egg counts. What are the major monitoring tools that are available? When and how often should you be performing wormer treatments in the first place? What's the difference between a good and a bad faecal egg count sample? And, what does resistance really mean? These are just some of the questions that we'll be tackling. Host: Ben EagleCo-host: Lesley StubbingsGuests: Rebecca Mearns (Senior Veterinary Advisor at Biobest) and Anna Hawke (farming near Salisbury).

Our latest episode features guest speaker Dr Ginny Dodunski who joins Rumen Room host Dr Charlotte Westwood for a chat about all things internal parasites. As a New Zealand-based veterinarian and self proclaimed “gumboot parasitologist”, Ginny requires little introduction to most kiwis involved in farming. With a background in veterinary practice, farm consultancy and more recently, working part time with Wormwise, Ginny joins us to cover a range of topics relating to internal parasite management in sheep and cattle. Given the concerning scale of resistance by internal parasites to our range of anthelmintic (drench) products, Ginny steps us through a range of down to earth, practical recommendations to managing internal parasites – including the important role for top quality nutrition for maternal and young stock. Anyone who is involved in managing young stock should tune in - there will be some  practical tips and tricks for everyone. Have a scroll (below) through the content for our latest episode featuring Ginny Dodunski.  0.50 Ginny's background and how her passion for all things animal health, and how her journey working with internal parasites began. 6.05 The timeline of New Zealand resistance since the days of effective anthelmintics 7.00 The cost of internal parasites (including resistance issues) to the New Zealand pastoral industries - and at the level of individual farms 8.40 The novel drenches, Zolvix™ Plus (monepantel and abamectin) and Startect® (derquantel and abamectin) help uncover the true cost of internal parasite resistance in lambs 9.50 Picking up sub-clinical internal parasite challenges (or not!) – especially when other autumn health challenges are occurring 12.10 Who to talk to if you suspect internal parasite resistance issues at your place 13.45 Is my drench working or not? Faecal egg counts 15.15 Starting the internal parasite journey – starting with the ewe/lamb(s) unit 16.25 Higher lambing percentages and internal parasite challenges (and opportunities) 18.40 Well fed ewes support good lamb weaning weights, reducing numbers of lambs on farm post-weaning 22.40 Anthelmintic treatments for ewes pre-lambing (or not) 24.10 Ewe nutrition and body condition– building tolerance to internal parasites 28.35 Hatching and development rates of larvae – differs for eggs from ewes and lambs 30.20 Ewe stocking rate combined with other stock classes – optimising ewe nutrition 32.50 Three Pillars of Parasite Management 33.30 First Pillar = well fed, healthy robust breeding stock 33.35 Second Pillar = young stock on clean feed (less worm larvae than average hill country pasture) 34.40 What's the best crop for lambs?  37.45 Feeding lambs the best quality feed that you can – the Third Pillar 38.10 Gross margin analyses on forage crops – understates the value of crops for young stock 39.00 Preparing pasture areas to finish lambs on – integrating cattle with sheep 40.00 100kg calves (dairy replacements, dairy beef) and internal parasites 43.00 Buying in 100kg calves – cautions around risk of parasite resistance 44.20 Holding young stock in yards to empty out after quarantine drenches 46.30 Faecal egg counting in young cattle – usefulness for different ages of cattle 48.40 Trace elements / trace minerals and internal parasites 52.05 Where to go to learn more about internal parasites

Dr Philip Smith, Digital and Education Editor of Gut and Honorary Consultant Gastroenterologist at the Royal Liverpool Hospital, UK, interviews Professor Loris Lopetuso, Department of Medicine and Ageing Sciences, University of Chieti-Pescara, Italy, on the paper "The first international Rome consensus conference on gut microbiota and faecal microbiota transplantation in inflammatory bowel disease", published in paper copy in Gut in September 2023, and available online: https://gut.bmj.com/content/72/9/1642  Please subscribe to the Gut Podcast via all podcast platforms, including Apple Podcasts, Google Podcasts, Stitcher and Spotify, to get the latest podcast every month. If you enjoy our podcast, please consider leaving us a review or a comment on the Gut Podcast iTunes page (https://podcasts.apple.com/gb/podcast/gut-podcast/id330976727).  

In this podcast Laura Peachey discusses the faecal microbiome of Exmoor ponies and Pearce Sloan discusses racing performance of juvenile Thoroughbreds with femoropatellar osteochondrosis at auction.

Faecal transplant, also known as faecal microbiota transplantation or FMT, is the transfer of stool from a healthy donor to a patient with a disease. The idea is to restore the balance of bacteria in the gut, which can be disrupted by factors such as antibiotics, diet, or infection but it could potentially help with a  range of problems from irritable bowel syndrome to Alzheimer's.  Why is faecal transplant used? How does faecal transplant work? How is faecal transplant performed? What are the risks of faecal transplant?  In under 3 minutes, we answer your questions! To listen to the last episodes, you can click here : How can I relax my brain while on holiday? What is a ‘lazy girl' job? How can I choose the right mattress for me? A podcast written and realised by Joseph Chance. In partnership with upday UK. Learn more about your ad choices. Visit megaphone.fm/adchoices

Essentially every culture, modern or ancient, understood that health and faeces are inherently linked. The Ancient Chinese practiced ‘copromancy' which was the assessment of health based upon the shape, size and texture of faeces. Today we have the Bristol Stool Chart that helps us to classify faeces/poo into seven different groups. As disconcerting as it may be, the state of our poo can tell us a lot about our own health and this is only going to increase as our knowledge about our faecal microbiome expands. The faecal microbiome is the composition of all the microorganisms within our faeces. We are learning that the composition not only affects our health but can also be contributory to diseases we experience. In some circumstances, this has also become a treatment with faecal transplantation to manage treatment resistant clostridium-difficile colitis. This is the story of the faecal microbiome. Our special guests: Dr Piers Mitchell, who is a hospital specialist consultant in the NHS and co-editor of the International Journal of Osteoarchaeology. Dr Mitchell has trained in paleopathology, osteoarchaeology, parasitology, medical history, and orthopaedic surgery. Dr Vincent Ho, who is a Gastroenterologist practicing in NSW, is an Associate Professor at Western Sydney University and head of a research laboratory. See omnystudio.com/listener for privacy information.

On this week's episode of No Holes Barred, Vic shares her close shave with an angry Alsatian, Laura shares her debut foray into doing stand up comedy and the girls discuss whether it's possible to recover from having explosive guts in front of your teenage son. This episode is sponsored by BetterHelp. Give online therapy a try at betterhelp.com/noholes and get on your way to being your best self. Get started today and enjoy 10% off your first month Learn more about your ad choices. Visit megaphone.fm/adchoices

Madeleine Finlay hears from science correspondent Linda Geddes about her experience becoming a faecal transplant donor, how getting a dose of someone else's gut bacteria could treat illnesses like arthritis, diabetes and cancer, and asks whether a pill made from poo is an idea we are ready to swallow. Help support our independent journalism at theguardian.com/sciencepod

Doctors Lisa and Sara talk to Dr Sarah Taylor about the changes being made to how Primary Care Clinicians refer patients for Suspected Lower Gastrointestinal Cancers. These changes are discussed in the context of referring in the Greater Manchester area, but you can view the  joint guideline from the Association of Coloproctology of Great Britain and Ireland (ACPGBI) and the British Society of Gastroenterology below.  This will change the way we manage patients. To help, we go through some potential cases. Good tips for how to mitigate potential risks with the changes included. We hope you find this useful. You can use these podcasts as part of your CPD - we don't do certificates but they still count :) Useful resources:  Faecal immunochemical testing (FIT) in patients with signs or symptoms of suspected colorectal cancer (CRC): a joint guideline from the Association of Coloproctology of Great Britain and Ireland (ACPGBI) and the British Society of Gastroenterology (BSG): https://www.bsg.org.uk/clinical-resource/faecal-immunochemical-testing-fit-in-patients-with-signs-or-symptoms-of-suspected-colorectal-cancer-crc-a-joint-guideline-from-the-acpgbi-and-the-bsg/ GatewayC FIT infographic: http://bit.ly/409mXUy GatewayC Lower GI infographic: http://bit.ly/3XJpIKN Raised Platelets and Cancer Risk: https://gpnotebook.com/en-au/simplepage.cfm?ID=x2019111783915921223 The Current NICE Guidelines last Updated December 2021: https://www.nice.org.uk/guidance/ng12/chapter/Recommendations-organised-by-site-of-cancer#lower-gastrointestinal-tract-cancers ___ We really want to make these episodes relevant and helpful: if you have any questions or want any particular areas covered then contact us on Twitter @PCKBpodcast, or leave a comment on our really quick anonymous survey here: https://pckb.org/feedback ___ This podcast has been made with the support of GP Excellence and Wigan CCG. Given that it is recorded with Greater Manchester clinicians, the information discussed may not be applicable elsewhere and it is important to consult local guidelines before making any treatment decisions.  The information presented is the personal opinion of the healthcare professional interviewed and might not be representative to all clinicians. It is based on their interpretation of current best practice and guidelines when the episode was recorded. Guidelines can change; To the best of our knowledge the information in this episode is up to date as of it's release but it is the listeners responsibility to review the information and make sure it is still up to date when they listen. Dr Lisa Adams, Dr Sara MacDermott and their interviewees are not liable for any advice, investigations, course of treatment, diagnosis or any other information, services or products listeners might pursue as a result of listening to this podcast - it is the clinicians responsibility to appraise the information given and review local and national guidelines before making treatment decisions. Reliance on information provided in this podcast is solely at the listeners risk. The podcast is designed to be used by trained healthcare professionals for education only. We do not recommend these for patients or the general public and they are not to be used as a method of diagnosis, opinion, treatment or medical advice for the general public. Do not delay seeking medical advice based on the information contained in this podcast. If you have questions regarding your health or feel you may have a medical condition then promptly seek the opinion of a trained healthcare professional.

Episode 145 feat. Adam, Toddy, Toddy J and Danggers. Come send it with the boys, as we discuss, The return of Covid, Danggers big move, Anus tattoos, WhatsApp girls, Faecal transplants, Blowing shit up, Possums, Mike Tyson gummies, Zelenskyy, Depression, Amber Turd, The rag doll cheater, Rumble Johnson, Abbie Chatfield, War Dogs, and much more... Please forward all complaints to: bigsendbigchat@gmail.com

Learn more about the podcast here - https://insidematters.health/episodes Debbie Shawcross is a clinician scientist and Professor of Hepatology and Chronic Liver Failure at Kings College London. She is a global key opinion leader in hepatic encephalopathy (HE) and has a specific research interest in why patients with advanced chronic liver disease are susceptible to developing an infection. Professor Shawcross also leads the gut microbial manipulation and chronic liver failure laboratory (Shawcross Laboratory) in the James Black Centre, Kings College London.   She is the Chief Investigator of the National Institute for Health Research (NIHR) EME-funded PROMISE Trial investigating faecal microbiota transplantation as a treatment for patients with alcohol and metabolic-related cirrhosis and Principal Investigator of the EU Horizon 20:20-funded MICROB-PREDICT Trial.   Liver disease is a growing problem globally, with 40% of adults alive today having excess fat accumulating in their livers. This condition, called fatty liver disease, is a starting point for a range of liver diseases including cirrhosis (scarring of the liver) and liver cancer.  There is a known link between the gut, liver and brain. These connections and interrelationships are called the ‘gut-liver-brain axis'. The liver and the blood are connected anatomically through the hepatic portal vein. The gut and the brain are connected anatomically through a nerve called the vagus nerve. More generally, the organs are connected through metabolites and signalling molecules produced by the gut microbiome that can travel in the blood. Multiple studies that have been conducted in humans and animals have shown that the microbiome plays a fundamental role in the development of liver disease and is therefore a promising potential target for prevention/treatment. In the episode, Professor Shawcross provides an excellent overview of what changes to the microbiome occur and why these are important. Briefly, in patients with liver disease, there is lower bacterial microbiome diversity (fewer species) and within the species that are residing, there are relatively higher proportions of bacteria that cause inflammation, as well as bacteria that are resistant to antibiotics (multi-drug resistant organisms ‘MDROs'). Additionally, in liver disease, a barrier that prevents bacteria from seeping out of the intestine into the blood/body becomes damaged and ‘leaky'. This process constellation results in something called ‘leaky gut'. As patients get sicker with the liver disease they progress to cirrhosis, and patients with cirrhosis can suffer from life-threatening complications, such as hepatic encephalopathy (HE). HE is a devastating condition that has parallels to dementia and severely impacts the quality of life in patients suffering from the disease.  The current standard of care (best available treatment) for HE is the combination of a laxative and an antibiotic, both modulating the gut microbiome. The treatments are inadequate through and there is still a high unmet need. Professor Shawcross believes that intestinal microbiota transfer (IMT) could be an effective solution that decolonises MDROs, improves the gut-intestinal barrier and improves the composition of the microbiome. Professor Shawcross completed an IMT study in patients suffering from cirrhosis (the PROFIT study) https://kclpure.kcl.ac.uk/portal/en/publications/profit-a-prospective-randomised-placebo-controlled-feasibility-trial-of-faecal-microbiota-transplantation-in-cirrhosis(4c186477-ea55-48eb-b7b9-a4b8b11d5099)/export.html. The results were promising, with IMT being safe, well tolerated and having favourable impacts on the microbiome. The success of this trial enabled Professor Shawcross to raise money from the NIHR to undertake a larger study (the PROMISE trial). Professor Shawcross is also involved in several other studies – the details of which can be found here: https://www.fmt-trials.org. Professor Shawcross's vision is to develop new treatments for patients with liver disease that modulate the microbiome. Dr James McIlroy and Professor Shawcross also discussed a number of other topics such as the microbiome in depression, the potential importance of coffee for liver health and much more. 00:39 Faecal microbiota transplantation (FMT) and the PROFIT trial 11:38 The microbiome in liver disease 13:58 The history of FMT in liver disease 18:35 Microbiome diversity 20:03 The impact of the pandemic on the microbiome 22:14 Types of liver disease 25:32 Treating cirrhosis 26:44 Hepatitis C and Hepatitis B 29:40 Fatty liver and the microbiome 32:27 Animal models and liver disease 33:15 Ammonia and liver disease 35:07 Hepatic Encephalopathy  39:15 The gut barrier 41:52 Hepatic Encephalopathy 46:40 The PROMISE trial 54:24 The liver and mental health 58:37 The threat of antimicrobial resistance 1:02:22 The FERARO trial 1:03:30 Coffee and the liver 1:05:33 Probiotics in liver disease 1:09:15 Veganism 1:10:40 What makes a good FMT donor 1:12:30 Antibiotics before FMT 1:14:16 Diet and FMT

Simon Baunwall (Aarhus University Hospital) discusses the EarlyFMT trial, a randomized placebo-controlled trial of faecal microbiota transplantation for first or second Clostridioides difficile infection.Read the full article:Faecal microbiota transplantation for first or second Clostridioides difficile infection (EarlyFMT)

Link to bioRxiv paper: http://biorxiv.org/cgi/content/short/2022.11.04.515189v1?rss=1 Authors: Grabrucker, S., Marizzoni, M., Silajdzic, E., Lopizzo, N., Mombelli, E., Nicolas, S., Dohm-Hansen, S., Scassellati, C., Moretti, D., Rosa, M., Hoffmann, K., English, J. A., Lavelle, A., O'Neill, C., Thuret, S., Cattaneo, A., Nolan, Y. M. Abstract: The gut microbiome is emerging as an important susceptibility factor in Alzheimers disease (AD) possibly due to the increased prevalence of pro-inflammatory genera in gut microbiota of AD participants. Microbiota-mediated changes in cognition and adult hippocampal neurogenesis (AHN), an important process for memory which is altered in AD, position the microbiota-gut-brain axis as a key regulator of AD. However, it is unknown whether gut microbiota alterations are the cause or consequence of AD symptoms. We transplanted faecal microbiota from AD participants and age-matched controls into microbiota-depleted naive adult rats and found impairments in AHN and associated memory tasks, which correlated with clinical cognitive scores. Discrete changes in the rat caecal and hippocampal metabolome were evident. Serum from AD participants also decreased neurogenesis in vitro and correlated with cognitive scores and pro-inflammatory genera. Our results reveal that the cognitive symptoms in AD may be due to alterations in gut microbiota, and that impaired neurogenesis may be a mechanistic link between altered gut microbiota and cognitive impairment in AD. Copy rights belong to original authors. Visit the link for more info Podcast created by Paper Player, LLC

In this episode of PodMD, Colorectal & General Surgeon Dr David Lam will be discussing the topic of faecal incontinence, including what faecal incontinence is, the causes of faecal incontinence, the types of treatment available, any warning signs to look out for, when to refer and more.

The Food and Drink Administration in the States has recently recommended the use of faecal transplants to treat various bacterial infections. We spoke to Dr Benjamin Mullish, a researcher at Imperial College London's Department of Metabolism, Digestion and Reproduction, about this promising new technique. Hosted on Acast. See acast.com/privacy for more information.

Visit our website to learn more about Inside Matters - https://insidematters.health/episodes/dr-richard-hansen   Watch the conversation on our YouTube channel - https://www.youtube.com/watch?v=nZma2Kh-umQ&ab_channel=InsideMattersPodcast   Dr Hansen is a Consultant Paediatric Gastroenterologist at the Royal Hospital for Children in Glasgow and an Honorary Clinical Associate Professor at the University of Glasgow. He is a principal investigator within the Bacteria, Immunology, Gastroenterology and ‘Omics (BINGO) group at the University which developed the CD-TREAT diet for Crohn's disease.   His clinical interests are inflammatory bowel disease (IBD), paediatric endoscopy and Helicobacter pylori. His main research interest is the gastrointestinal mucosal microbiota and its importance in paediatric disease, particularly IBD. He is especially interested in the molecular characterisation of the microbiota and its subsequent modification for the purposes of therapeutic effect via microbial therapeutics.   In this episode, we discuss treating IBD in children, using entirely liquid diets to reduce inflammation, and developing novel strategies that target the microbiome to treat IBD.   1:06 - Intro 1:56 - Interview Starts 2:27 – How to study the microbiome – analytical methods and study types 3:22 - How has microbiome science changed over the last 5 years? 5:13 -  What is Exclusive Enteral Nutrition (EEN)? 7:39 -  What is Inflammatory Bowel Disease (IBD)? 10:18 - Why are people getting IBD earlier in life? 14:54 - Is there different immunology between Crohn's disease and IBD? 17:07 - How has the perceived importance of the microbiome changed in IBD? 21:48 - How did all of this influence your PhD?  26:14 - Are we missing something with the current microbiome studies? 29:17 – The Bristol Stool Score 29:53 - Do you think that the microbiome drives inflammation in the gut? 34:01 – The Appendix  39:15 – Using the microbiome to predict IBD? 46:16 – Faecal microbiota transplantation (FMT) 49:03 – FMT in UC – studies published to date. 52:17 – Super donors in FMT 59:17 – The 16S gene 1:03:06 – The microbiome analytical toolkit 1:07:55 -  AI and large populations 1:09:19 – The implantation of machine learning 1:10:39 - Are clinicians trained in how to use AI 1:13:01 - Discussion on the application of FMT in paediatric populations. 1:14:22 - Infants, diet and gut health. 1:18:01 – Further discussion on FMT in paediatric populations. 1:20:44 - FMT donor screening processes.  1:22:21 – Donor selection for paediatric FMT. 1:26:30 – Potential risks associated with FMT.  1:29:19 - Can FMT or other microbial therapeutics replace immune system dampening therapies? 1:31:13 - When IBD is at its worst, what is it like? 1:36:01 - What do we do about the EEN diet and Crohn's disease? 1:38:20 - Which element of EEN is driving the positive effects in Crohn's? 1:42:27 - How do we create a less socially restrictive diet than EEN but keep the benefits? 1:44:44 - What is the ultimate aim of CDTreat?  1:47:19 - What is the relative importance of bacteria versus other components of the microbiome?   Key takeaways from this episode:   There has been an explosion of interest in the microbiome in recent times as it is becoming it easier and easier to analyse the microbiome through analytical methods that do not involve traditional culture techniques - which are labour intensive and relatively slow.    The field of microbial therapeutics is still in its infancy. There are many ongoing clinical trials into new ideas. Richard is hopeful that these trials will result in new treatment options for patients.    Inflammatory bowel disease is a chronic (long term) condition characterised by inflammation in the gut. There are two main forms of IBD, Crohn's disease and Ulcerative Colitis. Crohn's disease can affect any part of the intestinal tract, from mouth to anus. UC only affects the last part of the gut - the colon.    There is a microbiome that lives within the lumen of the gut and on the surface of the intestine (mucosa). Richard's analogy for this relationship is that they are like a beach and an ocean – they are different but inextricably linked.    The incidence (when the disease first starts) of IBD across the population seems to be occurring earlier and earlier in life. At the start of Richard's career it was rare to see a patient below the age of five presenting to hospital with symptoms, now days it is becoming more common. The environment and its impact on the microbiome may be the key driver for this. There are clear changes that are observed in microbiome studies in patients with reduced IBD, namely: reductions in diversity (how many bacteria are there and how evenly are they spread), and increases / decreases in particular bacteria.    Exclusive internal nutrition (EEN) is a term used to describe a 6-8 week course of an entirely liquid diet. The data suggests 4 out of 5 paediatric patients suffering from Crohn's disease enter remission (where the gut is healed and there is no active disease causing symptoms) after a course of EEN. It thought that the longer the course of EEN the more effective it is.    EEN is becoming much more popular in adult therapy, however its uptake is limited due to social constraints. Richard and a team working at the University of Glasgow are developing a less socially restrictive diet that mimics the effects of EEN. The programme of work is called CD-treat.    Intestinal microbiota transfer (IMT) involves the movement of microorganisms from one person into another with the intention of treating a disease. Six randomised controlled trials have been published in UC so far, with a definite signal towards IMT being effective. Richard is hopeful that these studies will pave the way for new treatment options in IBD. 

Gut Immune Body Brain Axis.Dr Gundry:Leaky Gut, gut microbiome and dietRenowned Cardiovascular Surgeon who realised that all he was doing was treating thesymptoms so he studied the underlying causes.The lining of the gut is one cell thickAs bacteria break down the gut that is when ageing startsIbuprofen or roundup disastrous the bacteria populationSkin is a mirror of the lining of the gutJoints do not naturally wear out.Animal model C Elegans as bacteria begin to break down the wall of the gut that is whenageing starts105 year old people have a diverse set of bugs identical to a healthy 30 year old. It is notattacking the wall of the gut.Ecermansia musinophilia. Lives in the mucous layer whose job is to trap lectins plantproteins looking for sugar molecules and to protect the wall of the gut from harmful bacteria.Ecermansia musinophilia eats mucus which in turn makes more mucus.Metformin works by increasing mucous and this change in bacteria makes some peoplehave mild diarrhoea as the bacteria change.If we damage this lining eg ibuprofen or food with roundup destroys the bacteria populationand gut lining.Glyocosade an antibacterial damages Ecermansia Musinophilia even though it does notdirectly affect human cells.Antibiotics in food or direct prescription eg ladies who take low dose for UTI have a higherincidence of heart disease.Heart disease is an autoimmune disease starting in the gut.Cholesterol is an innocent bystander which gets sucked into the inflamed wall of a bloodvessel.Infants with heart transplants have coronary artery disease with pathology identical withtypical coronary artery disease.Lectins which are a foreign protein which can stick to sugar molecules on the surface ofblood vessels are the cause of atherosclerosis and removing lectins reduces those markers.Lectins are one of the plant defence systems. Sticky proteins that look for specific sugarmolecules to stick to which insights an inflammtory response.Joints do not normally wear out. Usually you can find bacterial particles in the joint fluid ofarthritisBecauseLectins broke down the wall of the gut. 65% of the immune system is behind the wall of thegut because the gut is where the outside word gets through. A reason why we store fat inthe gut is to provide energy to the immune system. Similarly fat on the outside ofatherosclerotcic blood vessles correlates with the severity of inflammation.Fat is not the cause . It is there because of the inflammation and the inflammation is theredue to the leaky gut.The immune system responds to antigens on bacteria of viruses. Lectins have antigens withcross reactivity with other proteins in the body. Eg thyroid.Nightshade vegetables or peanutsLectins disrupt the microbiome and break up the lining of the gut allowing entry by lectinsand by bacteria or bacterial particles.Hence if you inject a bacterial lipopolysaccharide into a person you can induce septic shock.Alzheimers Parkinsons is neuroinflammation.Most amyloid is produced by bacteria in the gut. Therefore 40 billion dollars invested inantiamyloid drugs has been a waste because amyloid is produced by the amyloid producingbacteria inthe gut fet by western diet. Then the amyloid has to get through the wall of the gut.Once they get through the gut wall and goto the brain it will produce more amyloid.Cholesterol and amyloid coexist in dementia in those with the apoE gene.The apo E gene codes for a carrier molecule because it is less efficient at transportingcholesterol. It cannot get out of the cell after it has been attracted by inflammation.Faecal microbial transplant:1970s broad spectrum antibiotics came out which made it much quicker to treat infectionsbut it also wiped out the gut bacteria. Normally 10000 species of bacteria.Pseudomembranous colitis was caused by Clostridium Difficile over growing. Initial studydone from the faeces of medical students.Faecal enemas treated the pseudomembranous colitis.Meat with animals treated by antibiotics can also cause problems.60% of faeces is bacteriaOral microbiome and cloud of bacteria around us –Holobiome . This defines our personalspace.Kissing is a human and ape characteristic. Exchanging oral microbiome. Bacteria decidewhether the other person's bacteria are compatible with them.Women have a gut feeling because they are more capable of listening to their microbiome. We inherit our microbiome from our mother. All of the mitochondria are involved with bacteriainherited from our mother. Bacteria communicate to their ‘sisters 'ie the body's mitochondria.Autism: kids have a different microbiome than ‘normal'The placental microbiome is important in educating the foetal immune system.Oral faecal transplants for 6 weeks in autistic kids. Almost immediately 50% autismsymptoms reduced.Ecermansia like tubers, mushrooms, -study in Asia find 90% reduction in Alzheimers withtwo cups of mushrooms a week.Inulin containing compounds eg chicory, radicchio, jerusalem artichoke.Exercise women who exercise routinely from midlife have a 90% reduction in Alzheimers. Inthose who get AD it happens 11 years later. Housework can be important part of exercise.Meditation and yoga also changes the gut microbiome.Lymph system in the brain in deep sleep -early in the sleep cycle-shrinks by 20% and thesebad proteins are squeezed out. You need a 3-4 hour window between sleep and dinnerbecause blood flow diverts to the gut.Olive oil /walnuts / mediterranean low fat diet: first two groups improved memory after 5years. 3rd group lost memoryThose with CVD had a 30% reduction in events, the low fat group continued CVS events.Polyphenos in olive oil grow proteinsTMAO is made by gut bacteria primarily from animal protein especially choline eg egg yolkand carnitine . TMAO damages blood vessels. Polyphenols in certain olive oil and red winebalsamic vinegar that paralyse enzyme systems in the bacteria so they do not make TMAO.However the logical error here is that eggs which are high in choline are not associated withincreased morbidity.Vitamin D at least 5000 units a day . Almost all cancer patietns and autoimmune pateitnshave low vitamin D. HIgher your VItamin D the longer your telomere. Stem cells in the gutare simulated by vitamin D.VItamin CLectins are present in most plant foods but especially high in:legumes, such as beans, lentils, peas, soybeans, and peanutsnightshade vegetables, such as tomatoes and eggplantdairy products, including milkgrains, such as barley, quinoa, and riceThe Roll of Inflammation in Depression and FatigueFrontiers In Immunology:CH Lee 2019:Immune system link to depression first noticed with immunotherapy eg INFa (which activates an inflammatory antiviral response) for Hepatitis C : associated with raised proinflammatory cytokines and depression and fatigue.20% of patients treated with INFa developed depression which resolved on discontinuationbut also increased the risk of depression in future.Also people with higher IL6 aged 9 were more likely to have depression aged 18 in a dosedependent manner.Innate immune system seems to be lower in depression eg NK cells and also less antiinflammatory regulatory T cells whereas inflammatory monocytes are activated.There is commonality in immune activation from autoimmune disorder such as multiplesclerosis or immune reactions in sepsis.Antidepressants reduce inflammation while a higher baseline level of inflammation predicts apoorer treatment response.People with depression have been shown to have higher inflammatory markers which canbe used to predict treatment efficacy and future recurrences of depression.Elevated inflammatory markets eg TNFa after an MI disrupt the blood brain barrier causingdepression.Inflammatory changes in the brain with raised TNFa in the hippocampus and striatumprecede development of depressive symptoms.Neurogenesis is inhibited by the kynurenine pathway which is rescued by both inhibitors ofthis pathway and traditional antidepressants.TNFa also increases glutamate release causing exocytotic damage to surroundingsneurones.Conditions associated with chronic immune activation such as asthma, atopy, diabetes mMS, RhA, SLE are all associated with raised levels of depression eg 36% of asthma havedepression who also had higher TNFa than those who were not depressed. 75% in RhAMS up to 50% risk of depression.Acute inflammation with sepsis also causes depression and raises the risk of depression infuture which in animal models can be reduced by using steroid during the acute sepsis.Antidepressants reduce inflammatory markers perhaps SNRI more effective than SSRI andalso ECT adds in return to normal of NK activity.Directly reducing the immune response eg anti TNF a or Caspase Inhibitors have beenshown to reduce depression. Rituximab which is an antibody that targets and depletes Bcells in the treatment of RhA also reduces depression.Aspirin can reduce depression but can also reduce the effect of an SSRI.

Dr Philip Smith, Digital and Education Editor of Gut and Consultant Gastroenterologist at the Royal Liverpool Hospital, Liverpool, UK, interviews Professor Peer Bork, Director of the Heidelberg site of the European Molecular Biology Laboratory Heidelberg, Baden, Germany on the paper 'A faecal microbiota signature with high specificity for pancreatic cancer' published in paper copy in Gut in July 2022, and available online: https://gut.bmj.com/content/71/7/1359 Please subscribe to the Gut Podcast via all podcast platforms, including Apple Podcasts, Google Podcasts, Stitcher and Spotify, to get the latest podcast every month. If you enjoy our podcast, please consider leaving us a review or a comment on the Gut Podcast iTunes page (https://podcasts.apple.com/gb/podcast/gut-podcast/id330976727).

This week's podcast is supported by our friends over at Nuzest. You can get 20% off their amazing vegan protein by visiting nuzest.us/pbn20! Welcome back to another episode of the Plant Based News podcast. Today we sit down today with leading gastroenterologist, nutritionist, and author Dr. WIll Bulsiewicz. Dr. WIll Bulsiewicz, also known as Dr. B and The Gut Health MD, is a graduate of Georgetown University School of Medicine. He trained in internal medicine at Northwestern Memorial Hospital and in gastroenterology at The University of North Carolina Hospitals. He is board-certified in internal medicine and gastroenterology and an expert in digestive diseases. He is a New York Times, USA Today, and Publishers Weekly bestselling author and his latest cookbook “The Fiber Fueled Cookbook” extends his previous work by delivering “deeply flavorful, satisfying plant-based recipes” that target food intolerances. I am thrilled to welcome Dr WIll Bulsiewicz to this episode of the PBN podcast, where we'll dig deeper into what makes for a good diet and a healthy gut, how to combat food intolerances as well as his own journey as a physician and an author. 00:00:00 Nuzest Sponsor Promo 00:03:20 An introduction to Dr Will Bulsiewicz 00:06:10 The beginning of Dr B's plant-based journey 00:14:10 YouTuber Rachel tries out the Fibre Fuelled food plan 00:16:45 Plant Based News' Robbie Lockie's food intolerance 00:26:10 What is happening in the body when people experience pain from food intolerance? 00:36:30 What should we do to protect our immune system during the pandemic? 00:47:00 The importance of a covid-19 vaccine and a healthy diet 01:04:20 Faecal transplants 01:09:30 The connection between our brain and our gut 01:18:40 Shared microbes: the importance of food in relationships Find out more about Dr B here - https://theplantfedgut.com/ Find the transcript here - https://share.descript.com/view/YrluK0mLnaN The PBN Podcast is hosted and produced by Robbie Lockie, Edited by Phil Marriott.

Ja, dat klinkt nogal vies. Maar dat is precies waar onderzoekers naar gekeken hebben: kan het transplanteren van poepmicroben veroudering tegengaan?  Het transplanteren van deze microben van de ene persoon naar de andere heeft al langer de aandacht van onderzoekers. Zo is al gekeken of op die manier problemen met darmflora opgelost kunnen worden. Dan worden de goedwerkende microben van een donor, geplaatst bij iemand waarbij het darm-microbioom verstoord is.   Nu hebben onderzoekers bij muizen gekeken: wat gebeurt er als we de microben van jong naar oud transplanteren? Ze zagen dat door dit te doen, veroudering in de darm, ogen en hersenen deels teruggedraaid kon worden. Draaiden ze het experiment om en plaatsten ze microben van oude muizen in jonge muizen, dan kregen deze muizen allemaal vervelende klachten.   Het team van onderzoekers wil nu nog kijken hoe de microben nou precies deze veranderingen ingang zetten en hoe lang het effect aanhoudt. Lees meer: Faecal transplants reverse hallmarks of ageing.  See omnystudio.com/listener for privacy information.

Faecal sludge, a material derived from human waste, can be difficult to dispose of and causes significant disease and pollution worldwide. However, it also shows potential as a fuel, fertiliser and even a building material, if properly treated. Dr Santiago [san-tee-ah-go] Septien [sep-tee-uhn] Stringel and his team at the WASH R&D [wash R and D] Centre of the University of KwaZulu-Natal [kwah-zoo-loo-nay-taal], in Durban, South Africa, have been investigating the process for drying faecal sludge, towards developing new ways of transforming it into sustainable products.

Dive into some recent news, and things going on with the ICEBAR podcast. ICEBAR stickers are selling for only 3$ make sure to buy a sticker to support one of the best podcasts.

Faecal transfer is an unconventional treatment that restores the balance in your gut. Dr Andrea Henden from QIMR Berghofer takes us on a fascinating look into how healthy gut bacteria can be introduced into the bowel. The process is offering new hope for the common and sometimes deadly graft versus host disease which can affect the gut. There are also implications for millions with other gut and bowel issues.

Rupert Leong (University of Sydney) discusses a new double-blind, randomised, placebo-controlled trial of oral faecal microbiota transplantation for patients with active ulcerative colitis.Read the full article:Lyophilised oral faecal microbiota transplantation for ulcerative colitis (LOTUS)

Australia is lucky to have free healthcare services—but there can be big gaps in who receives it; reports on two people with bipolar disorder finding benefit from a faecal microbiota transplant; and how stomas help the intestine heal.

Recently published, independent, and peer-reviewed Australian case studies have reported on two people with bipolar disorder finding that their symptoms eased, or even disappeared, after they had a faecal microbiota transplant. So what do your poo and your mood have in common?

Raana attempts to hide in the Dino Dens but Silaqui is convinced there's another way to find out if Bone Cruncher is being given performance enhancing drugs. Taban and Percival consider a proposition by Kweothe.   Please subscribe, download and review us! https://linktr.ee/TotTTBpodcast   With great thanks and love, Trolls of the Two Tonne Bridges uses music and sound from the following artists:   3 Ghosts I 8 Ghosts I by Nine Inch Nails Creative Commons Attribution Non-Commercial Share Alike license License: http://creativecommons.org/licenses/by-nc-sa/3.0/us/   Tempting Secrets by Kevin MacLeod Link: https://incompetech.filmmusic.io/song/5005-tempting-secrets License: http://creativecommons.org/licenses/by/4.0/   Vanishing by Kevin MacLeod Link: https://incompetech.filmmusic.io/song/4578-vanishing License: http://creativecommons.org/licenses/by/4.0/   Bathhouse by Michael Ghelfi YouTube: https://www.youtube.com/user/MichaelGhelfi Patreon: http://www.patreon.com/MichaelGhelfi   Various by Tabletop Audio Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License License: https://creativecommons.org/licenses/by-nc-nd/4.0/   (All audio may have been edited for length or context)

In this third Q&A instalment of the podcast we delve into the use of isometrics, potentiation techniques, the mechanics of quadricep and hamstring training, and Luke decides to talk about faecal transplants.

Today we are joined by Dr Hans Seltenreich Gastroenterologist and Hepatologist and founder of the Coastal Digestive Health clinic on the Sunshine Coast, QLD.  We have a yarn about the gut microbiome/microbiota and the role of faecal transplants.  In particular: 1.  What is the microbiome? 2. What is it impacted by? 3. What are its roles in the human body? 4. What is its role in disease? 5. What is the role of faecal transplants? As always - enjoy. 

Pre and Probiotic Use in SIBO In this episode, Dr Nirala Jacobi is in conversation with Dr Jason Hawrelak on the topic of all things gut. Dr Hawrelak is a researcher, lecturer, naturopath, and nutritionist with over 16 years of clinical experience.  He also practices at Gould's Natural Medicine - a 135 year old natural medicine apothecary and clinic in Hobart, Tasmania, Australia.   Dr Hawrelak completed his PhD examining the capacity of probiotics, prebiotics, and herbal medicines to modify the gastrointestinal tract microbiota.  He is currently the senior lecturer in Complementary and Alternative Medicines at the University of Tasmania's School of Medicine where he coordinates the evidence based complementary medicines programs.  Dr Hawrelak also teaches the gastrointestinal imbalances unit, within the Masters of Science and Human Nutrition, and Functional Medicine Program at the University of Western States, in Portland, Oregon.   Topics discussed in this episode include: Dr Hawrelak's 2016 lecture on Pre and Probiotics at the SIBO Summit 2017 - still available to practitioners as part of the SIBO Fundamentals online course. The website Dr Hawrelak developed, Probiotic Advisor, to help practitioners differentiate which probiotic strains and products are appropriate to different conditions. Recent probiotic research (2017) in relation to SIBO treatment and methane reduction. The importance of strain specificity in relation to therapeutic effect. Reseeding the gut with exogenous probiotics as an outdated concept, and the history of this ideology. Faecal transplants and the capacity of strains to remain in the gut as compared to probiotics taken in capsule form that does not. What metabolic modulation actions do probiotics have in the body, and how to integrate this with background changes to enhance the therapeutic effect. D-lactate V.S. L-lactate producing probiotic strains, and what systemic effects do each trigger? D-lactic acidosis and when this may occur. SIBO related symptom presentation and strain specificity for probiotic therapy, for symptoms such as motility issues, abdominal hypersensitivity, histamine issues, food reactions.   Motility Probiomax for motility Bifidobacterium Lactis HNO19 - 1-2 capsules per day. BB12 Bifidobacterium Lactis for motility. Suggestions on the combination use in children with constipation. Animal study showing probiotic strains that work on the migrating motor complex function - prokinetic potential. Combination of L. Rhamnosus GG, Bifidobacterium BB12, and inulin.   Abdominal hypersensitivity in SIBO Bifidobacterium Infantis 35624 Align Rhamnosus GG Functional abdominal pain in kids - meta analysis supporting this therapeutic application. Nissle 1917 strain of E.Coli Bifidobacterium Lactis DN173010 Speed up transit time Decrease pain and bloating Yoghurt brand, Activia, available in US, is the only available form (as currently known)   Leaky Gut Probiotics useful in helping to repair leaky gut Rhamnosus LGG Biocodex preparation of Saccharomyces Cerevisiae/Boulardii   Histamine Intolerance Infiltration of mast cells into the intestinal wall in SIBO and histamine implication. Probiotics and histamine degradation - investigating Rhamnosus Infantis Plantarum Probiotics and histamine upregulation - investigating Casei Bulgaricus High-fat diets producing many bile salts, which feed hydrogen sulfide producing bacteria, and hydrogen sulfide gas contributing to leaky gut. Higher fat diets contributing to diamine oxidase (DAO) enzyme overuse in the small intestine and why this is relevant to histamine. Ketogenic diets and symptom resolution - why is this, and is it sustainable? The impact of starving out butyrate producing colonic flora. The risk of ketogenic diets.   Continued How to reintroduce foods to sensitive patients Heal gut Decrease inflammation Work on allergy axis to increase dietary diversity Partially hydrolysed guar gum (PHGG) as a prebiotic Probiotics as aiding in the recovery of the microbiome after an insult, eg chemotherapy, antibiotics, radiotherapy etc. Prebiotics and changes of diet having a greater impact on the gut microbiome. Jason's prebiotic use PHGG - use in functional constipation patients, non-methane type SIBO, and diarrhoea type stool conditions. Helps to normalise stool. Bimuno - galacto oligosaccharides Bringing bifidobacterium, and faecalibacterium prausnitzii populations back. Faecalibacterium prausnitzii: The single species with the highest prevalence in healthy people. Predominant butyrate producer. Produces another anti-inflammatory gut healing compound, so helpful for inflammatory bowel diseases. Higher levels as protective against metabolic syndrome and Type 2 Diabetes. Akkermansia Accounts for 1-3% of the microbiome in healthy people. Eats mucin, therefore if inflamed guts producing a lot of mucus can overgrow akkermansia. Lactulose Use as a prebiotic. Increases faecalibacterium prausnitzii, akkermansia, and bifidobacteria, lactobacilli. Use as a pH changer - moves environment to be more beneficially acidic. Amazing capacity to decrease Bacteroides numbers - which can increase after multiple courses of antibiotics. SIBO positive on Lactulose breath test patients - to attend to SIBO with therapy first before using Lactulose as a prebiotic. Lactulose uses in recurrent urinary tract infections as supported by clinical trials - as it decreases levels of E.coli in the gut so fewer pathogens can make the journey from the anus, to the vagina, to the urethra. Prokinetic for small intestine and when it is appropriate to use it in SIBO. Note: lactulose will increase gas, but not bloating. If bloating, cease use. Discussion on soil based organisms as they relate to functional digestive disorders.   Resources BioGaia sunflower oil based probiotics Blackmores Digestive Bio Balance Rob Knight - microbiome specialist Products mentioned: Motility Probiomax Bifidobacterium Lactis HNO19 - 1-2 capsules per day. Lactobacillus reuteri MM53 BioGaia strain Testing mentioned Ubiome GI effects from Genova Diagnostics Dr Hawrelak's Probiotic Advisor