Podcasts about delayed diagnosis

Why do we wait? Why do we sometimes ignore those nagging health concerns? Join host Talaya Dendy on Navigating Cancer TOGETHER as she shares her journey of delaying medical attention for a year after a doctor dismissed her initial worries. Discover the relatable reasons behind her hesitation, from the pressures of work and family to the underlying fear of what she might find. Talaya unpacks the research behind why so many of us delay seeking medical help and emphasizes the crucial importance of listening to your body and becoming your own best health advocate. Are you putting off a doctor's visit? This episode might just be the nudge you need!

IG Living's patient advocate, Abbie Cornett, hosts Nick Burrus, a Kawasaki disease patient, to discuss his journey with the disease that due to a delayed diagnosis led to complications and the need for a heart transplant.Support the show

Send us a textMary Humphries tells how her son Dan was diagnosed with diabetes aged 16 and it was assumed he had type 1 diabetes and treated with insulin.  On insulin he had terrible problems with low blood sugars frequently losing consciousness and not managing to concentrate at school or at home.  Mary was very worried that he was getting worse on the insulin and asked about genetic tests because she had recently been diagnosed with Type 2 diabetes and there was diabetes in all generations of her family.  She was not listened to; the insulin was continued, and Dan got worse.  Searching the internet for answers she found the Exeter diabetesgenes.org website which led her to talking to Andrew and Maggie. They were able to rapidly diagnose that this was Maturity-onset Diabetes of the Young (MODY), subtype HNF1A . with a genetic test.   Maggie  helped Dan to stop his insulin and get excellent control on a quarter of the sulphonylurea tablet called gliclazide.  Dan rapidly improved off the insulin and passed his A levels with flying colours going to Bristol where he achieved his life's ambition to become a large animal vet.  

This is episode 1 of the series: ADHD in Females Misunderstood Symptoms, Delayed DiagnosisEpisode 1: In this podcast episode, explore ADHD in females, delving into unique challenges and barriers to accurate diagnosis and support. Debunking common misconceptions, it highlights gender differences in symptom manifestation and addresses societal expectations' impact. Tune in to gain insight into recognizing and treating ADHD in females, preventing long-term consequences. ---Nurses may be able to complete an accredited CE activity featuring content from this podcast and earn CE hours provided from Elite Learning by Colibri Healthcare. For more information, click hereAlready an Elite Member? Login hereLearn more about CE Podcasts from Elite Learning by Colibri HealthcareView Episode TranscriptView this podcast course on Elite LearningSeries: ADHD in Females Misunderstood Symptoms, Delayed Diagnosis

This is episode 2 of the series: ADHD in Females Misunderstood Symptoms, Delayed DiagnosisEpisode 2: In this episode, delve into how the environment influences the success of females with ADHD, along with interventions and resources crucial for their support. Uncover the enduring repercussions of undiagnosed or untreated ADHD, emphasizing the significance of awareness and advocacy for females with the condition. Key insights underscore the necessity of treatment access, therapy, societal expectation challenges, and equitable care, illustrated through inspiring success stories of early intervention's positive outcomes. ---Nurses may be able to complete an accredited CE activity featuring content from this podcast and earn CE hours provided from Elite Learning by Colibri Healthcare. For more information, click hereAlready an Elite Member? Login hereLearn more about CE Podcasts from Elite Learning by Colibri HealthcareView Episode TranscriptView this podcast course on Elite LearningSeries: ADHD in Females Misunderstood Symptoms, Delayed Diagnosis

When disease strikes, time becomes a critical resource our patients cannot afford to waste. For those with axial spondyloarthritis (axSpA), an inordinate amount of time often goes by before a proper diagnosis is made, resulting in delays for crucial treatments to be rendered. The reasons for this delay in diagnosis, particularly among those with axSpA are diverse, complicated and not well-understood. Our guest, Dr. Gregory McDermott, attempted to better understand this diagnostic delay with his study: Factors Associated With Diagnostic Delay in Axial Spondyloarthritis: Impact of Clinical Factors and Social Vulnerability  in hopes that we may begin answering these challenges with solutions.  

With decades of experience, Lowenthal & Abrams, P.C. has become a trusted name in personal injury and medical malpractice law. Their team of skilled attorneys is equipped to handle complex cases involving delayed cancer diagnosis, providing compassionate support and vigorous advocacy for their clients. Lowenthal & Abrams, P.C. City: Bala Cynwyd Address: 555 E City Ave. Website: https://lowenthalabrams.com/

In this episode, Chief Neil Dubord speaks with Detective Greg Linkert from the Calgary Police Service, who shares his journey of resilience in the face of adversity after being diagnosed with multiple sclerosis (MS). Greg discusses his career in law enforcement, including his time in specialty sections such as the tactical team and bomb unit. He recounts the symptoms he experienced before his MS diagnosis and the challenges he faced in accepting his condition. Greg emphasizes the importance of communication, support systems, and maintaining a positive mindset. He also shares his involvement in the MS walk and peer support programs.   Takeaways   Appreciate the simple things in life and find joy in everyday experiences. Adapt and accept the challenges that come with a diagnosis or disability. Maintain open communication with your support system and seek help when needed. Choose to define your own story and focus on the possibilities rather than dwelling on the past.   Chapters   00:00 Introduction 00:15 Appreciating Simple Things 00:30 Specialty Sections in Police Career 01:25 Greg Linkert's Career Journey 03:10 Diagnosis of MS 04:08 Living with MS 05:28 Refereeing and Skating Issues 06:26 Delayed Diagnosis of MS 07:24 First Real Incident of MS Symptoms 08:55 Continued Symptoms and Denial 09:23 Seeking Medical Help 10:21 36-Hour Adventure at the ER 11:16 MS Diagnosis Confirmed 12:44 Medical Professionals Involved 13:42 Physiatrist and Coping Skills 14:38 Peer Support and MS Walk 16:05 Fear and Adapting to MS 18:05 Teaching Recruit Class and Body Worn Camera 20:04 Life Now and Physical Limitations 22:30 Walking Around the Island 23:56 Support Systems 25:23 Importance of Communication 26:53 Choosing Your Story 28:19 Peer Support and Giving Back 28:55 Message to Others 30:25 Summary and Gratitude

Hey ya'll, I am baring it all in today's episode of Vagina Rehab Doctor Podcast. I dive deep into my personal journey with PCOS, sharing the challenges of irregular periods and the emotional toll it takes. From my early years of inconsistent birth control to the frustration of misdiagnoses, I open up about the doubts, the struggles, and the desire for answers. This episode is a raw and honest exploration of living with PCOS, hoping to break the stigma and let others facing similar struggles know they're not alone. Let's get into it! In this episode, you will be able to:Learn the keys to maintaining healthy menstruation and overcoming challenges with your menstrual health.Understand the symptoms of PCOS and how they can affect your overall well-being.Gain insights into the importance of seeking medical help for managing PCOS and optimizing your menstrual health.Empower yourself with knowledge about PCOS and take control of your menstrual health journey.The key moments in this episode are:00:00:00 - Introduction 00:01:37 - Understanding PCOS 00:05:01 - Irregular Periods and Ovulation 00:06:42 - Delayed Diagnosis and Symptoms 00:12:54 - Speaking Positively and Having Faith 00:13:37 - Lifestyle Changes and Supplements 00:15:12 - The Challenges of Entrepreneurship 00:16:21 - Struggling with PCOS and Body Image 00:19:50 - Building a Supportive Community Want 1 on 1 coaching to help you cancel sexual pain? Schedule a complimentary call with me by clicking here below!https://calendly.com/vaginarehabdoctor/discovery Shop my Vag Stretch Labs, E-guides, and Masterclasses for your vaginal health & fitnesshttps://vagina-rehab-doctor-boutique.myshopify.com/ Follow me on social media @vaginarehabdoctor Produced by Light On Creative Productions

The economic impact of a delayed diagnosis of a rare disease can result in up to $517,000 in avoidable costs per patient, according to a recent analysis from the Everylife Foundation for Rare Diseases and the Lewin Group. On average, the report found, it takes more than six years and nearly 17 doctor visits, hospitalizations, and other health-related trips, to receive a rare disease diagnosis after symptoms begin. Shortening the diagnostic odyssey saves money for individuals, caregivers, and the healthcare system, while improving health outcomes. We spoke to Annie Kennedy, chief of policy, advocacy, and patient engagement for the Everylife Foundation, about the diagnostic odyssey, the economic toll it takes, and what can be done to shorten the time to a diagnosis.

Gideon Asen attorney, Trevor Savage, joins the podcast to talk about a recent case he and Ben Gideon tried involving a delay in diagnosis of prostate cancer.  Ben and Trevor discuss some of the legal challenges they had to overcome and how they used focus groups and big data to identify key issues and frame the case effectively for trial.  They discuss their approach to voir dire, opening statements, use of demonstrative aides and order of witnesses.   About Trevor SavageTrevor is a skilled trial attorney who represents clients in claims involving medical malpractice, wrongful deaths and other complex personal injury cases.After completing a clerkship with the Maine Supreme Judicial Court, Trevor began his career at a large firm in Portland, representing medical providers, businesses, and insurance companies.Trevor's experience as a defense attorney gives him a unique perspective that he uses to give Gideon Asen's clients an advantage during litigation with insurance companies.A native of Maine, Trevor is a graduate of Emerson College in Boston, Massachusetts, and then the University of Maine School of Law. At Maine Law, he served as Managing Editor of the Maine Law Review and as a legal writing teaching assistant for first-year students.During law school—alongside his then-classmate and current colleague, Meryl Poulin—he distinguished himself as one of two “Prize Arguers” of their class and argued before the Maine Supreme Judicial Court. He and Meryl Poulin—another Gideon Asen attorney—later competed nationally as teammates on the Maine Law Moot Court Team, finishing in the top three of a competition of more than forty teams.While at law school, Trevor interned with the Appellate Division of the United States Attorney's Office and then with Judge Kermit V. Lipez of the United States Court of Appeals for the First Circuit. He also worked as a Student Attorney at the Cumberland County District Attorney's Office (winning his first two jury trials as a second-year law student).Trevor lives in North Berwick, Maine, with his wife, Amy, and two children, Jacob and Will.

Have you ever felt like you just don't quite fit in this community of medically complex parents, because your life isn't “hard enough” or your child's disability or diagnosis isn't “severe enough?” Maddison has been living within this feeling of imposter syndrome for years now, as she's navigated the long and winding road to finally receiving her daughter Eleanor's rare diagnosis. In today's episode, Maddison shares with me how, despite her family's struggles, she's still had trouble feeling like she belonged in the medically complex community, and how she eventually came to terms with that reality. We also dive into the trickiness around overcompensating with our children who have disabilities and what it feels like when the people around us seem to be over our children's recurrent medical issues. If you've ever felt like you're still finding your place in our community, this is one episode you can't miss! And a big thank you to our sponsor GeneDx for making this episode possible. Check out their website for more information on genetic testing if you're still searching for a diagnosis in your family. Links: Check out our generous sponsor for this episode GeneDx! Follow Maddison on Instagram @maddisonjhall! Follow us on Instagram @the_rare_life! Donate to the podcast or Contact me about sponsoring an episode. Fill out our contact form to get a reminder about upcoming discussion meetings and the Skype link to join! Follow the Facebook page. Join the Facebook group Parents of Children with Rare Conditions. Access the transcript on the website here. And if you love this podcast, please leave us a rating or review in your favorite podcast app!

This week Mary discusses (and Alex reacts) to the medical and legal ramifications that can come from a delay in diagnosing endometriosis. #Podcast #Spotify #Anchor #research #advocacy #travel #endometriosis #delayeddiagnosis #patient advocacy Stay Connected  Email Us: downthereaware@gmail.com Instagram:@downthereaware  Facebook: Down There Aware  Twitter: @downthereaware Pinterest: Down There Aware TikTok: Down There Aware Episode Highlights Intro [0:13] Welcome Back! [1:23] Happy Easter! [1:40] What is the cost of a delayed diagnosis? [2:27] The overlap between endometriosis and other conditions. [3:32] Where a diagnosis starts  [4:37] Pitfalls of specialist referrals [10:05] Primary care physician superstars [12:32] Diagnosis stats [15:37] Why are there delays? [16:51] Dismissal of symptoms [17:20] Taking the easy route [20:22] Let's be real, some doctors are lazy [21:09] Will doesn't have a clue [21:27] The legal perspective of a delayed diagnosis [22:55] Whoops lost the camera feed! [23:02] Sadie joins us (and is bored with all of the liturgical talk [23:34] Patient vs. Doctor responsibility in a delayed diagnosis [24:23] Maggie's diagnosis [25:46] Sometimes delayed diagnosis is unavoidable [26:33] Signs of a delayed diagnosis [27:00] Lack of coordination between specialist [30:15] It's a team effort [32:10] Thanks for listening! [34:47] Summary Keywords Podcast, Spotify, Anchor, research, travel, ovarian cancer, insurance, delayed diagnosis, endometriosis, miscommunication, specialists, team effort, patient advocacy --- Send in a voice message: https://podcasters.spotify.com/pod/show/downthereaware/message

Welcome to another fun episode of the Brainiac podcast (episode 8, season 3 woot!) hosted by Melissa Biscardi in affiliation with University of Toronto, Concussion Legacy Foundation. Today we have Part 2 with our friend, concussion advocate, veteran and so much more- Amanda Burrill. In this episode Amanda shares about some life changing concussions that happened and how she found her way to some amazing clinicians and clinics across the USA. She shares about how she chose activities she could manage that from the outside seem surprising. Amanda is a light hearted soul and it is a treat to listen to her story.....so much so that we still had to say: To be continued, in Part 3. If you didn't catch the last episode definitely check it out..Disclaimer: This episode talks about head injury and the details of blood loss at multiple points through the episode..Please follow and support us on Instagram, we would love to connect:Melissa Biscardi:www.concussionrehab.ca@concussionrehab.caAmanda Burrill@amandaunchartedConcussion Legacy Foundationhttps://concussionfoundation.org@concussion.canUniversity of Toronto Chapter@concussion.can.utoronto Get bonus content on PatreonSupport this show http://supporter.acast.com/concussion-talk-podcast. Hosted on Acast. See acast.com/privacy for more information.

Women make up nearly half of the world's population and have higher rates of neurological disorders, yet there is still a gap when it comes to better understanding and treating women living with brain-related illnesses. Many women also face systemic barriers and biases when they seek help, often leading to a delay in diagnosis and treatment.Featuring: Dr. Esther Bui - Neurologist and clinician educator at UHN's Krembil Brain Institute and assistant professor at the University of Toronto. Her research includes the creation of Canada's first accredited Women's Neurology Clinic and training program.  Find her on Twitter: @womensneurologyDr. Mary Angela O'Neal - Director of the Women's Neurology program at the Brigham and Women's Hospital in Boston, and an assistant professor of neurology at Harvard University. Dr. O'Neal also directs a Harvard Medical School course in Women's Neurology and Psychiatry.Nikki Ashworth – Experiencing seizures since she was a child, Nikki was only diagnosed with temporal lobe epilepsy in her 30s. Her seizures may come without warning, but she's been turning her experience into an art form with her dark and honest unintentional comedy. Find Nikki on IG: @strange_missRoshan Malhan - A second-year medical student at the University of Toronto's Temerty Faculty of Medicine, where he acts as a co-director for the Anesthesia Interest Group and Emergency Medicine Interest Group. He is currently exploring his interests in a number of medical specialties and looking forward to gaining additional insights during clerkship. Additional resources: UHN Epilepsy ClinicUHN Foundation ‘Know Your Heroes' Q&A with Dr. BuiCanadian Leader in Neurology: Dr. BuiBrigham and Women's Hospital Women's Neurology ProgramWomen's Health in Neurology – Dr. O'Neal (video)The Lullaby Project (Massey Hall & Roy Thomson Hall)“My epileptic seizures can hurt my pregnancy. I wrote a lullaby to soothe my baby and my fears” Julianne Hazlewood – CBC (podcast)The Krembil Brain Institute, part of University Health Network, in Toronto, is home to one of the world's largest and most comprehensive teams of physicians and scientists uniquely working hand-in-hand to prevent and confront problems of the brain and spine, such as Parkinson's, Alzheimer's, epilepsy, stroke, spinal cord injury, chronic pain, brain cancer or concussion, in their lifetime. Through state-of-the-art patient care and advanced research, we are working relentlessly toward finding new treatments and cures.Do you want to know more about the Krembil Brain Institute at UHN? Visit us at: uhn.ca/krembilTo get in touch, email us at krembil@uhnresearch.ca or message us on social media:Instagram - @krembilresearchTwitter - @KBI_UHNFacebook - https://www.facebook.com/KrembilBrainInstituteThanks for listening!

Welcome to the Brainiac podcast!In this episode Brainiac host Melissa Biscardi speaks with Amanda Burrill, a TBI advocate, veteran, chef, adventurist and more. Amanda shares her story, how she became a rescue swimmer, her journey to learning she has a TBI (or a few) and the health providers she has met along the way. Amanda carries such a positive energy, and is always working towards living her life to the fullest. She knew about holistic brain care 'before it was cool' as we like to say. Amanda has been navigating her symptoms and recovery since the early 2000s....before there was as much support and research as there is today. In her own words "the brain is fantastic and plastic!" There was so much to talk about that an episode two is needed- and we will think you agree that we want to hear more about this fantastic human and her life. To connect with us more please follow us on instagram!Melissa: @concussionrehab.caAmanda: @amandaunchartedConcussion Legacy Foundation Canada: @concussion.canUniversity of Toronto CLF: @concussion.can.utoronto Get bonus content on PatreonSupport this show http://supporter.acast.com/concussion-talk-podcast. Hosted on Acast. See acast.com/privacy for more information.

In April 2019, Tony Hannon from Listowel died from cancer. He was part of a group of 11 patients at University Hospital Kerry who suffered a delayed diagnosis due to X-ray and scan failures. Tony’s wife Marcella speaks to Jerry.

In this episode, Paul E. Sax, MD, discusses the latest recommendations and options for HIV pre-exposure prophylaxis (PrEP), including:CDC PrEP guideline 2021 updates for oral PrEPThe ANRS IPERGAY study: on-demand oral emtricitabine (FTC)/tenofovir disoproxil fumarate (TDF) PrEP in men who have sex with men who are at high risk for HIV infectionA review of the HPTN 083 and 084 studies: efficacy and safety of long-acting (LA) injectable cabotegravir (CAB) vs daily oral FTC/TDF for PrEP1-year follow-up after unblinding for HPTN 083 and 084LA CAB for PrEP: monitoring and safetyStopping LA CAB for PrEPPresenter: Paul E. Sax, MDClinical DirectorHIV Program and Division of Infectious DiseasesBrigham and Women's HospitalProfessor of MedicineHarvard Medical SchoolBoston, MassachusettsLink to full program:https://bit.ly/3VIsDTgFollow along with the slides at:https://bit.ly/3Gh9AKG

In this episode I discuss an article from the website VeryWell Health. It looks at delayed diagnosis for women with AS. Here is a link to https://www.verywellhealth.com/ankylosing-spondylitis-symptoms-in-women-5090710?utm_campaign=17328398598-de35d7c71d6b11&utm_source=googleawpaid&utm_medium=con&utm_content=600229841473&utm_term=g-ankylosing%20symptoms&gclid=Cj0KCQjwjvaYBhDlARIsAO8PkE3hLtmTDVAQ8D-1VRsHWPyV0xxMpbEXMc-U_n4kyd2FL_UmxKjCbysaAngZEALw_wcB (article). Make sure to check out The Faces of Ankylosing Spondylitis. Here is a link to https://thefacesofankylosingspondylitis.com/?blogsub=confirming#subscribe-blog (website). I'm number 158 if you are curious. If you are not part of this wonder page, submit your story. Cookie wants to get to 2700 people on the site, but I bet we can get her way past this. All the below links are affiliate links. If you purchase any of the items, I may earn a small commission. It does not change the price of items. Get paid to take tests. Here is a link to Rare Patient Voice. If you take participate in a study, you can get paid (amount varies). https://rarepatientvoice.com/TheAxialSpondyloarthritisPodcast/ (https://rarepatientvoice.com/TheAxialSpondyloarthritisPodcast/) Here are some links to Amazon showing some of the items I discussed. Uberlube - https://amzn.to/3i604N2 (https://amzn.to/3i604N2) Here is the Bean Bag neck warmer https://amzn.to/3uN6mcg (https://amzn.to/3uN6mcg) Biofreeze - https://amzn.to/33gygBS (https://amzn.to/33gygBS) Cane - https://amzn.to/3uN9fts (https://amzn.to/3uN9fts) Heating Pad - https://amzn.to/3Bjd5vz (https://amzn.to/3Bjd5vz) Weighted Blanket - https://amzn.to/36RCdi7 (https://amzn.to/36RCdi7) Steff Di Pardo's new book - I Am Not Invisible - https://amzn.to/3JpDScA (https://amzn.to/3JpDScA) All My Ankylosing Spondylitis Shit: Pain and Symptom Tracker by Kinsella Love https://amzn.to/34CHhpx (https://amzn.to/34CHhpx)

Rojas Law Group (813-437-1542) has built a reputation for being the best personal injury law firm for residents in Lake Mary, FL seeking justice for their medical malpractice cases. It offers services in Spanish and English. Learn more at https://rojaslawgroup.com (https://rojaslawgroup.com)

Emma is joined by Kristen Cascio, together they discuss: * Kristen going undiagnosed with obstructive sleep apnea for years.   * Thyroid issues and how those were a convenient excuse for fatigue and daytime sleepiness. * Getting diagnosed with obstructive sleep apnea using an at-home sleep study. * Feeling relief to have answers to sleep problems. * Adjusting to CPAP therapy with the help of her supportive husband. * Starting @meandmycpap on Instagram and sharing tips on traveling with CPAP. Follow Kristen on Instagram @meandmycpap This episode is sponsored by Inspire https://www.inspiresleep.com/ Airway Management https://tapintosleep.com/ BetterHelp https://www.betterhelp.com/emma Get your FREE Video Download '3 Tips to Better Sleep with Obstructive Sleep Apnea' by following the link here: https://www.sleepapneastories.com/ Follow the podcast on Instagram: @sleepapneastories Email Emma at sleepapneastories@gmail.com www.sleepapneastories.com Disclaimer: this episode of the podcast includes people with sleep apnea discussing their own experiences of medical procedures and devices.  This is for information purposes only and you should consult with your own medical professionals before you start or stop any medication or treatment.

Susan Giusto and Dr. Scott Coven will talk about the Pediatric Cancer problem of Delayed Diagnosis on today's podcast. This happens more than it should, as Pediatrician's can take too long to order the proper procedures or tests which ultimately can diagnosis whether a child has cancer.  By waiting too long, this can put the child in a position where their treatment begins much later than it should, causing all types of issues that be detrimental to their recovery. 

In this episode from the series “Key Decisions in HIV Care,” Latesha Elopre, MD, MSPH, and Karine Lacombe, MD, PhD, discuss important considerations for PrEP in cisgender men and transgender women, including:Discussion of the PrEP gap and racial and gender disparities in PrEP access CDC, EACS, and WHO guidance on PrEP eligibility PrEP regimens currently recommended for adults and adolescents including FTC/TDF daily, FTC/TAF daily, and long-acting cabotegravir Data from clinical trials on the efficacy of FTC/TDF daily for men including Partners PrEP, TDF2, iPrEx, iPrEx OLE, and PROUD Data from the ANRS IPERGAY study on the use of FTC/TDF on demand Data from the DISCOVER trial on the use of FTC/TAF for PrEP Data from the HPTN 083 study on the use of long-acting cabotegravir as PrEP for cisgender men Clinical monitoring and considerations during PrEP usePresenters:Latesha Elopre, MDAssociate ProfessorDivision of Infectious DiseasesAssistant Dean of Diversity and InclusionGeneral Medical EducationUniversity of Alabama at BirminghamBirmingham, AlabamaKarine Lacombe, MD, PhDProfessorUMR-S1136Sorbonne UniversityHead, Infectious Diseases DepartmentSt Antoine Hospital, AP-HPParis, FranceContent based on an online CME program supported by educational grants from Gilead Sciences, Inc.; Janssen Therapeutics, Division of Janssen Products, LP; and ViiV Healthcare.Follow along with the slides at:https://bit.ly/3uqPje3Link to full program:https://bit.ly/3q2DlGd

In this episode from the series “Key Decisions in HIV Care,” Latesha Elopre, MD, MSPH, and Karine Lacombe, MD, PhD, discuss important considerations for PrEP in cisgender women, including: Discussion of the PrEP gap and racial and gender disparities in PrEP accessCDC, EACS, and WHO guidance on PrEP eligibilityPrEP regimens currently recommended for adults and adolescents including FTC/TDF daily, FTC/TAF daily, and long-acting cabotegravirData from phase III trials on the efficacy of FTC/TDF daily for women including Partners PrEP, TDF, VOICE, and FEM-PrEPPharmacokinetic data of FTC/TDF and FTC/TAF in the female genital tract and discussion of why on-demand dosing of FTC/TDF is not recommended in cisgender womenData and recommendations for the use of the dapivirine ring from ASPIRE and The Ring Study and their open-label extensions, DREAM and HOPEData from the HPTN084 study on the use of long-acting cabotegravir as PrEP for cisgender womenRecommendations for the use of PrEP during pregnancy and breastfeedingClinical monitoring and considerations during PrEP usePresenters:Latesha Elopre, MD, MSPHAssociate ProfessorDivision of Infectious DiseasesAssistant Dean of Diversity and InclusionGeneral Medical EducationUniversity of Alabama at BirminghamBirmingham, Alabama Karine Lacombe, MD, PhDProfessorUMR-S1136Sorbonne UniversityHead, Infectious Diseases DepartmentSt Antoine Hospital, AP-HPParis, France Content based on an online CME program supported by educational grants from Gilead Sciences, Inc.; Janssen Therapeutics, Division of Janssen Products, LP; and ViiV Healthcare.Follow along with the slides at: https://bit.ly/36s2ovBLink to full program:https://bit.ly/3q2DlGd

In this episode, Jason Schafer, PharmD, MPH, explores key considerations for the use of long-acting injectable pre-exposure prophylaxis (PrEP).- Listen as he gives his perspectives on:- The FDA approval of long-acting cabotegravir for PrEP- Healthcare professionals' clinical concerns with long-acting injectable antiretroviral therapy- Considerations for long-acting cabotegravir as PrEPDosing and administrationManaging missed dosesDiscontinuationDelays in HIV diagnoses found in the HPTN 083 study in men- CDC recommendations for HIV screening while receiving PrEPPresenter:Jason Schafer, PharmD, MPHProfessor and Vice ChairJefferson College of PharmacyThomas Jefferson UniversityPhiladelphia, Pennsylvania  Follow along with the slides at: https://bit.ly/3wugMOCSee the entire program at: https://bit.ly/3q2DlGd

In this episode, Jason Schafer, PharmD, MPH, explores the data for long-acting injectable pre-exposure prophylaxis (PrEP).Listen as he gives his perspectives on the:PrEP pipeline and the importance of having options for patients with differing preferencesFDA approval of long-acting cabotegravir for PrEPHPTN 083 and 084 studies of long-acting cabotegravir for PrEP compared with oral emtricitabine/tenofovir disoproxil fumarateSafety data on long-acting cabotegravir for PrEPCDC recommendations on the management of injection-site reactions with cabotegravir for PrEPPresenter:Jason Schafer, PharmD, MPHProfessor and Vice ChairJefferson College of PharmacyThomas Jefferson UniversityPhiladelphia, Pennsylvania Follow along with the slides at:https://bit.ly/3tbvEPKSee the entire program at: https://bit.ly/3q2DlGd

Trying to find the ‘why' of why you feel a certain way can lead you down a lot of different paths.  Today's guest Stephanie Kurland has been living with chronic pain for about 14 years due to childhood head injuries, four car wrecks, a trampoline accident, and 23 years of headbanging at heavy metal concerts, but she was only officially diagnosed with TBI and PCS two years ago. Her constant daily managing of symptoms has taken her on a long journey of self discovery. She's dug deep and expressed her feelings through art therapy, Reiki, and years of research for creating a holistic lifestyle.  Today she joins us to share her story. She explains how her distrust of doctors led her to do her own research to get to the root of her anxiety and pain. She talks about the treatments and therapies she has tried from conventional physiotherapy to unconventional karaoke and expressing herself through art. Tune in to find out what Stephanie has learned on her journey and why she believes that you should connect with yourself, share your experiences, and be the ripple that starts the great change in the world! Get your own TheraSpecs https://theraspecs.com/ Use code BELLA15 for $15 OFF! Find Show Notes, & More: https://postconcussioninc.com/podcast Support the Podcast! If you love the podcast please consider supporting us through our tip jar! All tips are greatly appreciated. (https://postconcussioninc.ck.page/products/support)

Racial and Ethnic Disparities in the Delayed Diagnosis of Appendicitis Among Children by SAEM

Appendicitis is the most common surgical condition in pediatric emergency department (ED) patients. Prompt diagnosis can reduce morbidity, including appendiceal perforation. The goal of this study was to measure racial/ethnic differences in rates of 1) appendiceal perforation, 2) delayed diagnosis of appendicitis, and 3) diagnostic imaging during prior visit(s).

The cost of a delayed diagnosis of fibromyalgia can be tremendous. There can be a huge impact due to the cost of unnecessary treatments or incomplete fixes. There is also the cost of lost income. In addition, there is also a big emotional cost to delayed diagnosis and incomplete management.The audiobook, Conquering Your Fibromyalgia, is now available. You can get a copy of the book here. Blog and website available here.If you have questions or topics you would like to have discussed on a future podcast, email Dr. Lenz at doctormichaellenz@gmail.com. You can also share a recording of your question. If you have a question, it is likely that hundreds of others have the same question. 

Dr. Brian Goldman talks to Karen Townsend, a lawyer and mom from London Ontario who says that her cancer would have been found earlier if she had been able to see her doctor in person, but because of COVID, she was only allowed a virtual visit. Dr. Tony Eskander, a surgical oncologist in Toronto he's seeing many patients with cancers of the head and neck getting diagnosed at later stages than he's used to. He talks about the impact.

Kaitlin Christine is the CEO & Founder of Gabbi, a FemTech company aiming to solve delayed diagnosis of preventable diseases that affect women, starting with breast cancer. Kaitlin is a breast cancer survivor and ovarian cancer previvor who has made it her life's mission to empower women to understand their bodies and advocate for themselves. Kaitlin has spent over 9 years in women’s health--working for leading nonprofits, as a sought after national speaker, was the youngest hire for the world’s leading genetic testing company where she led sales and eventually transitioned to a role as a hereditary cancer specialist, and most recently was the VP of Growth for an e-commerce marketing startup. Kaitlin earned her Bachelor of Arts from the University of Denver. We discussed Kaitlin's personal journey with breast cancer, barriers to entry in healthcare, gaps in awareness and innovation for breast cancer. Check out Gabbi at www.begabbi.com Rate, Review & Subscribe!

I will be discussing a 20-year-old girl with a 3 year history of multiple sclerosis treated with B cell suppressive therapy . She was prescribed two biological disease-modifying antirheumatic drug (DMARD).This article was written by Sjowall and colleagues in the journal Frontiers in Neurology. She was initially prescribed tocilizumab, marketed in the US as Actemra.   Tocilizumab is a monoclonal antibody blocks signals from IL-6 receptors them, is a monoclonal antibody against the interleukin-6 receptor. Tocilizumab can lower the ability of your immune system to fight infections.She was subsequently prescribed rituximab, sold under the brand name Rituxan, another B- cell treatment.She suffered for 6 months with knee arthritis and a persistent rash. Lyme disease was considered by dismissed at the Lyme disease tests were negative.She was finally treated 6 months after the fact with doxyc ycline. 1.         Sjowall J, Xirotagaros G, Anderson CD, Sjowall C, Dahle C. Case Report: Borrelia-DNA Revealed the Cause of Arthritis and Dermatitis During Treatment With Rituximab. Front Neurol. 2021;12:645298 .You can hear more about these cases through his blogs, social media, and YouTube. Sign up for our newsletter to keep up with these cases.How to Connect with Dr. Daniel Cameron:Check out his website: https://www.DanielCameronMD.com/Call his office: 914-666-4665Email him: DCameron@DanielCameronMD.com Send him a request:  https://danielcameronmd.com/contact-daniel-cameron-md/Like him on Instagram: https://www.instagram.com/drdanielcameron/Join his Facebook group: https://www.facebook.com/danielcameronmd/Follow him on Twitter: https://twitter.com/DrDanielCameronSign up for his newsletter: https://www.DanielCameronMD.com/Subscribe and ring the bell: https://www.youtube.com/user/danielcameronmd/ Leave a review on iTunes or wherever else you get your podcasts.We, of course, hope you’ll join the conversation, connect with us and other readers, ask questions, and share your insights. Dr. Cameron is a Lyme disease expert and the author "Inside Lyme: An expert's guide to the science of Lyme disease." He has been treating adolescents and adults for more than 30 years.Please remember that the advice given is general and not intended as specific advice as to any particular patient. If you require specific advice, then please seek that advice from an experienced professional.

I will be discussing a unique case involving a 67-year-old man whose diagnosis of Lyme disease was delayed because clinicians suspected his symptoms were due to COVID-19. This case was described by Novak and colleagues in the journal Case Rep Infect Dis.In July 2020, the man presented with symptoms consistent with COVID-19 with chills, body aches, fever, headache, and neck ache. He was encouraged to be quarantined.Six weeks later he developed an erythema migrans (EM) rash. He was treated with with doxycycline for either an insect bite or rash. A week later he developed double vision due to a 6th nerve palsy, headaches, neck stiffness, and new onset fatigue. His was diagnosed and treated with Lyme disease at a Lyme disease telemedicine referral clinic.Novak CB, Scheeler VM, Aucott JN. Lyme Disease in the Era of COVID-19: A Delayed Diagnosis and Risk for Complications. Case Rep Infect Dis. 2021 You can hear more about these cases through his blogs, social media, and YouTube. Sign up for our newsletter to keep up with these cases.How to Connect with Dr. Daniel Cameron:Check out his website: https://www.DanielCameronMD.com/Call his office: 914-666-4665Email him: DCameron@DanielCameronMD.com Send him a request: https://danielcameronmd.com/contact-daniel-cameron-md/Like him on Instagram: https://www.instagram.com/drdanielcameron/Join his Facebook group: https://www.facebook.com/danielcameronmd/Follow him on Twitter: https://twitter.com/DrDanielCameronSign up for his newsletter: https://www.DanielCameronMD.com/Subscribe and ring the bell: https://www.youtube.com/user/danielcameronmd/ Leave a review on iTunes or wherever else you get your podcasts.We, of course, hope you’ll join the conversation, connect with us and other readers, ask questions, and share your insights. Dr. Cameron is a Lyme disease expert and the author "Inside Lyme: An expert's guide to the science of Lyme disease." He has been treating adolescents and adults for more than 30 years.Please remember that the advice given is general and not intended as specific advice as to any particular patient. If you require specific advice, then please seek that advice from an experienced professional.

Host: Jennifer Caudle, DO Guest: Coy Heldermon, MD, PhD Guest: Heather Lau, MD, MS Several questions are often brought to light when it comes to detecting and diagnosing Gaucher disease, such as how does it present, what genetic factors to consider, and how to go about making an accurate diagnosis. Here to answer those and other questions are practicing hematologist oncologist Dr. Coy Heldermon and neurogeneticist Dr. Heather Lau. For more information on the diagnostic and therapeutic landscape for Gaucher disease, including access to Sanofi Genzyme Rare Disease Registries, visit Gauchercare.com/hcp, a Sanofi Genzyme website. MAT-US-2024074 2/2021

A recent study by Johns Hopkins asserts that over 250,000 people in the United States die from medical errors every year. Other studies put the number to be more than 440,000. Medical errors are now the third-largest cause of death in the United States, according to the CDC. According to HG.org, diagnosis errors affect 20% of medical cases in the United States. This episode is about some of the issues faced by individuals affected by the failure to diagnose, delayed diagnosis, or the misdiagnosis of cancer.Approximately 40,000 cancer patients die annually due to failure to diagnose, misdiagnosis, or delayed diagnosis.Is the failure to diagnose and misdiagnosis of cancer considered medical negligence or medical malpractice? It depends on the case.In your case of misdiagnosis or failure to diagnose, it may not be clear if the standard of care has been met by a medical professional. However, you should always make sure you talk to a medical malpractice attorney and have it investigated.If you have a case for medical malpractice because of a failure to diagnose, misdiagnosis, or delayed diagnosis, that means something really, really bad has happened to you.If you are ever skeptical about what a doctor is telling you, then always get that second or third opinion again because you don't want to have a medical malpractice case on your hands.To find out more about the National Injured Senior Law Center or to set up a free consultation, go to https://www.injuredseniorhotline.com/ or call 855-622-6530CONNECT WITH STEVE H. HEISLER:Website:  www.injuredseniorhotline.comFacebook: https://www.facebook.com/attorneysteveheisler/LinkedIn: https://www.linkedin.com/company/the-law-offices-of-steven-h.-heisler/about/Email: info@injuredseniorhotline.com

This is a podcast summary of "Global Dialysis Perspective: Mexico" by Magdalena Madero Rovalo and Enzo Christopher Vazquez

Jane Ferguson:                Hello, and welcome to episode 26 of Getting Personal: Omics of the Heart, the podcast from Circulation: Genomic and Precision Medicine. I'm Jane Ferguson. It's March 2019, and I'm ready to spring into this month's papers, and apparently make really bad seasonal related jokes. Sorry all. Okay, let's get started.                                            First up, is a paper from Oren Akerborg, Rapolas Spalinskas, Sailendra Pradhananga, Pelin Sahlén and colleagues from the Royal Institute of Technology in Solna, Sweden entitled "High Resolution Regulatory Maps Connect Vascular Risk Variants to Disease Related Pathways." Their goal was to identify non-coding variants associated with coronary artery disease, particularly those with putative enhancers and to map these to changes in gene function. They generated genomic interaction maps using Hi-C chromosome confirmation capture, coupled with sequence capture in several cell types, including aortic and ethelial cells, smooth muscle cells and LPS stimulated THP-1 macrophages.                                            They captured over 25,000 features and they additionally sequenced the cellular transcriptomes and looked at epigenetic signatures using chromatin immunoprecipitation. They looked at regions interacting with gene promoters and found significant enrichment for enhancer elements. Looking at variants previously implicated in genome-wide associated studies, they identified 727 variants with promoter interactions and they were able to assign potential target genes for 398 GWAS variants.                                            In many cases, the gene associated with a particular variant was not the closest neighbor, highlighting the importance of considering chromatin lupane when assigning intergenic variants to a gene. They identified several variants that interacted with multiple promoters, influencing expression of several genes simultaneously.                                            Overall, this paper is a great resource for the community and takes many of these GWAS hits to the next level in starting to understand their biological relevance. They have a lot of supplemental material available online so it's definitely worth checking that out and taking a look for your favorite non-coding variant or chromosomal region to see if you can get some more information on it.                                            Next up, Pierrick Henneton, Michael Frank and colleagues from the Hopital Europeen Georges-Pompidou in Paris bring us "Accuracy of Clinical Diagnostic Criteria For Patients with Vascular Ehlers-Danlos Syndrome in a Tertiary Referral Center." The authors were interested in determining the accuracy of the diagnostic criteria used to select patients for genetic testing for suspected vascular Ehlers-Danlos syndrome. This is because, despite the Villefrench criteria being recommended for diagnosis, the accuracy of the diagnostic criteria was never formally tested.                                            They selected 519 subjects, including 384 probands and 135 relatives who had been seen between 2001 and 2016. They assessed the sensitivity and specificity of the Villefrench classification. Almost 32% of tested individuals carried a pathogenic COL3A1 variant. The sensitivity of the Villefrench criteria was 79% with a negative predictor value of 87%. Symptomatic probands had the highest accuracy at 92% sensitivity and 95% negative predictive value. However, the specificity was just 60%.                                            Applying revised diagnostic criteria from 2017, it was actually less accurate because even though there was an increase in specificity, the sensitivity was reduced. Overall diagnostic performance was worst in individuals under 25 and neither set of diagnostic classifications allowed for early clinical diagnosis in individuals without a family history.                                            Our next paper is a Mendelian randomization analysis from Susanna Larsson, Stephen Burgess and colleagues from Uppsala University and the University of Cambridge. This paper entitled "Thyroid Function And Dysfunction In Relation to Sixteen Cardiovascular Diseases: A Mendelian Randomization Study" aims to understand how subclinical thyroid dysfunction relates to risk of cardiovascular diseases. They generated genetic predictors for thyroid stimulating hormone, or TSH, through a GWAS meta-analysis in over 72,000 individuals. They then analyzed the association of genetically predicted TSH with cardiovascular outcomes in large GWAS studies of atrial fibrillation, coronary artery disease, and ischemic stroke, and further assessed associations with phenotypes in the UK Biobank.                                            They found genetically decreased TSH levels and hyperthyroidism were associated with increased risk of atrial fibrillation but not other tested phenotypes. Overall, these data support a causal role for TSH and thyroid dysfunction in atrial fibrillation but not in other cardiovascular diseases.                                            The next paper is also a Mendelian randomization analysis from members of the same group, Susanna Larsson, Stephen Burgess and colleagues published "Resting Heart Rate and Cardiovascular Diseases: A Mendelian Randomization Analysis." In this letter, they describe a study of the relationship between genetically increased resting heart rate and cardiovascular diseases. They constructed genetic predictors of resting heart rate and similarly to the previous study, used that as an instrument to test for associations with coronary artery disease, atrial fibrillation, and ischemic stroke in the cardiogram, atrial fibrillation, and mega stroke consortia respectively.                                            They also looked at 13 CVD outcomes in the UK Biobank. They found that genetically predicted heart rate was inversely associated with atrial fibrillation with suggestive evidence for an inverse association with ischemic, cardioembolic, and large artery stroke. The inverse association with AF was replicated in the UK Biobank, supporting previous reports linking resting heart rate to atrial fibrillation.                                            Next up, we have a letter from Robyn Hylind, Dominic Abrams, and colleagues from Boston Children's Hospital. This study entitled "Phenotypic Characterization of Individuals with Variants in Cardiovascular Genes in the Absence of a Primary Cardiovascular Indication For Testing" describes their work to probe incidental findings for potential cardiovascular disease variants in individuals undergoing clinical genomic sequencing for non-cardiac indications.                                            They included 33 individuals who had been referred as carrying variants that were indicated as being associated with cardiovascular disease in primary or secondary findings. The variants were reclassified using the 2015 ACMG guidelines, and then were compared to the original classification report obtained at the time of sequencing.                                            Of 10 pathogenic or likely pathogenic variants, only four of these were actually considered pathogenic or likely pathogenic after reclassification under the 2015 ACMG criteria, and none of these were associated with a cardiac phenotype. None of the variants could be definitively linked to any cardiac phenotype.                                            The costs ranged from $75 to over $3700 per subject with a cost per clinical cardiac finding estimated at almost $14,000. This study highlights the relatively high cost and low yield of investigating potential cardiovascular variants and prompts consideration of how to implement strategies to ensure that variant reporting maximizes clinical return but minimizes the financial, time, and psychological burdens inherent in lengthy follow-ups.                                            The next paper is a clinical letter from Serwet Demirdas, Gerben Schaaf and colleagues from Erasmus University Rotterdam  entitled "Delayed Diagnosis of Danon Disease in Patients Presenting with Isolated Cardiomyopathy." They report on a clinical case of a 14-year-old boy presenting with cardiac arrest due to ventricular fibrillation during exercise. Echocardiography and MRI showed cardiac concentric hypertrophy, particularly in the left ventricle. The boy's mother had died at age 31 after being diagnosed with peripartum dilated cardiomyopathy.                                            Sequencing in the boy revealed a variant in the LAMP2 gene, known to be responsible for Danon disease, which typically presents as cardiomyopathy, skeletal myopathy, and intellectual disability. This same LAMP2 variant was found in preserved maternal tissue, but not in other family members. In this case, there was no evidence of muscle or intellectual abnormalities. However, sequencing had allowed for this diagnosis of Danon disease in the child and posthumously in his mother. This study demonstrates a utility of using extended gene panels in clinical sequencing to aid in diagnosis and to inform management of patients.                                            The next letter is from Alvaro Roldan, Julian Palomino-Doza, Fernando Arribas and colleagues from University Hospital of the 12th of October in Madrid and is entitled "Missense Mutations in the FLNC Causing Familial Restrictive Cardiomyopathy: Growing Evidence." This report also highlights clinical cases. In this case, two individuals with variants in the filamin C, or FLNC gene. Two unrelated individuals presenting with restricting cardiomyopathy were sequenced and found to carry two different variants in the FLNC gene, one of which had not been previously reported.                                            This expands the number of reported cases of filamin C mutations in restrictive cardiomyopathy and highlights the need for further study of the pathophysiology linking filamin C to cardiac function.                                            Finally, we have some correspondence related to a previously published article. In the letter, Christopher Chung, Briana Davies, and Andrew Krahn comment on the recently published article from Jody Ingles on concealed arrhythmogenic right ventricular cardiomyopathy in sudden unexplained cardiac death events. In that paper earlier this year, they had reported on four cases of individuals presenting with cardiac arrest or sudden cardiac death, attributable to concealed arrhythmogenic right ventricular cardiomyopathy with underlying mutations in the plakophilin-2 gene. In the letter from Chung et al, they report similar findings where individuals may first experience electrical phenotypes before manifesting structurally detectable disease. Indeed, in their response to this letter, Ingles et al report identification of an additional case since publication of their original article.                                            Taken together, this further strengthens the case for development of additional strategies to identify at risk individuals and predict and prevent disease events.                                            That's all for the papers for March 2019. Go online to check them out and follow us on Twitter @Circ_Gen to see new papers as they are published online. Thanks for listening. Until next month everyone. This podcast was brought to you by Circulation Genomic and Precision Medicine and the American Heart Association Council on Genomic and Precision Medicine. This program is copyright American Heart Association 2019.  

The patient and his wife felt that the surgeon was not forthcoming with an explanation of what happened and seemed indifferent to the impact on his patient, following conversion to an open procedure and large blood loss.

Care required better resident supervision, closer follow-up on ordered test.

A female patient wasn't screened for colon cancer, despite routine involvement with three physicians.

Postoperative decline required communication to bring the attending's wisdom to the bedside.

A case where a sign-out checklist or documentation of an order may have prevented the patient's poor outcome.

Despite several evaluations in the ED and PCP office, the cause of pulmonary symptoms eluded providers, led to unnecessary surgery, fear of cancer--and a mid-range settlement.

A Q and A with Jack Mc Carthy, president of Harvard's self-insurance medical malpractice company about guidelines, simulators, and the future of patient safety.

Host: Mark Nolan Hill, MD Guest: Joseph Muenzer, MD Hunter syndrome is a rare but serious genetic disorder that inhibits the body's ability to break down specific complex carbohydrates. Initial onset symptoms include inguinal hernias, recurrent otitis, and the common cold, frequently manifesting concurrently as part of a multi-system failure sometime after the first year of life. Because many of these symptoms are common in infants, physicians often do not suspect Hunter syndrome, yet treatment for the disease is much more effective when administered early in its progression. How can we minimize the delay typically associated with diagnosis of Hunter syndrome? Dr. Joseph Muenzer, professor of pediatrics and genetics at the University of North Carolina School of Medicine, and one of the world's leading authorities in Hunter syndrome research, joins host Dr. Mark Nolan Hill to share his expertise.

Host: Mark Nolan Hill, MD Guest: Joseph Muenzer, MD Hunter syndrome is a rare but serious genetic disorder that inhibits the body’s ability to break down specific complex carbohydrates. Initial onset symptoms include inguinal hernias, recurrent otitis, and the common cold, frequently manifesting concurrently as part of a multi-system failure sometime after the first year of life. Because many of these symptoms are common in infants, physicians often do not suspect Hunter syndrome, yet treatment for the disease is much more effective when administered early in its progression. How can we minimize the delay typically associated with diagnosis of Hunter syndrome? Dr. Joseph Muenzer, professor of pediatrics and genetics at the University of North Carolina School of Medicine, and one of the world’s leading authorities in Hunter syndrome research, joins host Dr. Mark Nolan Hill to share his expertise.