Podcasts about fxi

Michael Belkin, a long-time market strategist and editor of the Belkin Report and Belkin Gold Stock Forecast, joins us for an in-depth conversation on why gold and gold stocks may be the last assets standing in an increasingly volatile and overvalued global market.   In this interview, Michael shares his evolving thesis since our last discussion in February, highlighting a parabolic move in gold, growing central bank demand, and how the supposed “most crowded trade”, as labeled in the recent Bank of America Global Fund Managers Survey, is still largely under-owned by institutional investors.   Key Topics Discussed: Why the "crowded trade" label on gold may be misleading - and actually bullish. How central banks are steadily de-dollarizing and reallocating into gold. The disconnect between rising gold prices and underperforming gold equities. Top stock picks: Newmont (NEM), Kinross (KGC), Iamgold (IAG), Harmony Gold (HMY), and B2Gold (BTG). Michael's silver favorites: First Majestic (AG) and Endeavour Silver (EXK). Whether generalist fund managers will be forced into large-cap gold stocks as earnings surge. A bleak outlook for global equities, AI bubble stocks like Nvidia, and international markets like the DAX and China's FXI. Why gold equities may diverge positively from the broader market even in a downturn. Gold Stock Forecasts are available at: BGSF  Discount Coupons are available upon request for KER listeners. Contact Marc at marcb@hyperpyron.com.

Jim Tassoni, CEO of Armored Wealth Strategies, joins us for his technical outlook on markets and resources. Jim is a momentum-focused trader targeting mid-term trends, and in this conversation, he shares how he's navigating one of the most volatile stretches of the year.   Despite a recent bounce in markets, Jim sees continued downside risk across major indices. He explains why his team initiated a short position on SPY, where they'd increase it, and what key technical levels they're watching to shift bullish. Jim also outlines a profitable short trade in IWM (small caps) and why the construction of the index keeps him cautious.   We then dive into gold and the broader precious metals space, where Jim remains long and bullish, but he's watching for a better re-entry point after a strong move. He outlines extension targets up to $3,600 for gold and levels of interest on GDX and copper.   On energy, Jim shares insights into a well-timed short crude oil trade and the critical levels he's tracking that could signal a reversal.    Finally, we wrap with international exposure, as Jim details his active long positions in Japan and China, including FXI and EWJ, and his key stop-loss levels.   Click here to visit the Armor Wealth Strategies website to keep up to date with Jim and what he's trading. 

Lester Kiewit speaks to Samkelo Mokhine, the executive director of the Freedom of Expression Institute (FXI) about the controversy stirred up by Julius Malema singing “Kill the boer” at a Human Rights Day rally. And, while a court has ruled that it is not hate speech, it is being used by Afrikaner groups to stoke the US’s anti-South Africa sentiment. Would it not be smart, and just plain good manners, to put the song to rest now?See omnystudio.com/listener for privacy information.

Stocks had a good bounce on Monday but they're probably going to need the help of the $MAGS if $SPX wants to keep up with a global rotation into $FXI and $EFA, says OJ Renick.======== Schwab Network ========Empowering every investor and trader, every market day.Subscribe to the Market Minute newsletter - https://schwabnetwork.com/subscribeDownload the iOS app - https://apps.apple.com/us/app/schwab-network/id1460719185Download the Amazon Fire Tv App - https://www.amazon.com/TD-Ameritrade-Network/dp/B07KRD76C7Watch on Sling - https://watch.sling.com/1/asset/191928615bd8d47686f94682aefaa007/watchWatch on Vizio - https://www.vizio.com/en/watchfreeplus-exploreWatch on DistroTV - https://www.distro.tv/live/schwab-network/Follow us on X – https://twitter.com/schwabnetworkFollow us on Facebook – https://www.facebook.com/schwabnetworkFollow us on LinkedIn - https://www.linkedin.com/company/schwab-network/About Schwab Network - https://schwabnetwork.com/about

Jenny Horne discusses the biggest trends 2024 had to offer. Cybersecurity took focus following July's Crowdstrike (CRWD) outages. Software flexed strength through names like Salesforce (CRM), Oracle (ORCL) and Palantir (PLTR). Volatility in China made U.S. stocks tied to the country ones to watch. Rick Ducat charts ETFs tied to the industries like HACK, IGV and FXI. ======== Schwab Network ======== Empowering every investor and trader, every market day. Subscribe to the Market Minute newsletter - https://schwabnetwork.com/subscribe Download the iOS app - https://apps.apple.com/us/app/schwab-... Download the Amazon Fire Tv App - https://www.amazon.com/TD-Ameritrade-... Watch on Sling - https://watch.sling.com/1/asset/19192... Watch on Vizio - https://www.vizio.com/en/watchfreeplu... Watch on DistroTV - https://www.distro.tv/live/schwab-net... Follow us on X – / schwabnetwork Follow us on Facebook – / schwabnetwork Follow us on LinkedIn - / schwab-network About Schwab Network - https://schwabnetwork.com/about

Register for the AI Webinar: https://www.riskreversal.com/events/transformingthefinanciallandscape Dan Nathan, Guy Adami and Carter Worth break down the top market headlines and bring you stock market trade ideas for Tuesday, December 3rd. Timecodes 0:00 - Intro 6:00 - S&P 500 20:00 - FXI & China 30:00 - INTC Trade 40:00 - Audience Q&A -- Register for the AI Webinar: https://www.riskreversal.com/events/transformingthefinanciallandscape Learn more about FactSet: https://www.factset.com/lp/mrkt-call Subscribe to our newsletter: https://riskreversalmedia.beehiiv.com/subscribe MRKT Call is brought to you by our presenting sponsors CME Group, FactSet & SoFi Watch MRKT Call LIVE at 1pm M-TH on YouTube Sign up for our emails Follow us on Twitter @MRKTCall Follow @GuyAdami on Twitter Follow @CarterBWorth on Twitter Follow us on Instagram @RiskReversalMedia Like us on Facebook @RiskReversal Watch all of our videos on YouTube

New Highs across the board – (Big Caps – not the small caps). China stocks get obliterated. Rates moving up – CPI report…. This week's guest, Patrick O'Hare – Chief Market Analyst for Briefing.com. Patrick has been with Briefing.com since 1997 and authors the Page One, The Big Picture, Fed Brief, Market View, and Economic Data Reviews columns. He also provides commentary on Live In Play. Every Wednesday morning Patrick is a guest on KDOW's The Rob Black Show. He is quoted regularly in the financial press and has also appeared on CBS Radio, CNBC, CNN International, Fox Business Network, and PBS' Nightly Business Report. Patrick is a graduate of Vanderbilt University and is located in Chicago. Follow @Briefingcom Check this out and find out more at: http://www.interactivebrokers.com/ Follow @andrewhorowitz  Stocks mentioned in this episode: (SPY), (FXI), (VXX), (MCHI)

Shocking – Rates running higher on better then expected jobs report. Oil on the move as the Middle East conflict intensifies. China and Emerging Markets on Fire – breaking out from long base. This week's guest - Tim Knight – a self proclaimed Permabear. Tim Knight has been charting and trading since 1987. His first stock trade was, in fact, on October 19, 1987 – the day of the crash – which perhaps goes a long way explaining his disposition toward bearishness. He has been involved in personal computers since late 1979 and, starting at age 16, began writing a couple dozen books about using and programming computers. His most recent writing has been focused on charting and the history of financial markets, including his newest books, Panic, Prosperity, and Progress, and, more recently, Silicon Valley Babble On and Solid State, his first novel. He has been running Slope since March 29 2005 and has, during that time, written more than 30,000 posts on the site. In 1992 Knight founded Prophet, a web-based technical analysis company that was acquired by Investools (and, later, Ameritrade) in January 2005. Tim served as Senior Vice President of Technology for Investools from 2005 through 2010. Both Barron's & Forbes consistently named Prophet the #1 website for technical analysis. Besides running the Slope of Hope, Tim also hosts a daily show on the tastylive network, Trading Charts with Tim Knight. You can find Sam Burns & Mill Street Research at https://slopeofhope.com/ and on Twitter at @slopeofhope. Check this out and find out more at: http://www.interactivebrokers.com/ CHARTS DISCUSSED IN THIS EPISODE Follow @andrewhorowitz Looking for style diversification? More information on the TDI Managed Growth Strategy - HERE Stocks mentioned in this episode: (SPY), (FXI), (QQQ)

Guy Adami, Dan Nathan, and Liz Young Thomas dive into the final Monday of September discussing the latest financial trends and market movements. They touch on China's economic stimulus efforts and its implications on global markets, particularly the S&P 500. Elizabeth provides insights into how China's actions could affect different sectors within the S&P and highlights the broader economic impact of China's growth targets. The gang also explore the performance of ETFs like FXI and delve into sector-specific stock analysis, including semiconductor stocks and consumer discretionary names like Nike. Looking ahead, they discuss the potential outcomes of the impending U.S. jobs report and its significance for market volatility, especially in light of the upcoming election cycle. After the break, Dan, Guy & Danny are joined by Vincent Daniel to discuss economic developments in China to the stimulus package and its impact on commodities, notably uranium (31:00). They discuss the high-profile investor David Tepper's bullish stance on China and explore the broader implications of global economic strategies. Vinny shares his experiences and observations from recent trades, highlighting sectors like housing, consumer credit, and energy. The trio also delves into the AI-driven demand for energy and the evolving market for precious metals like gold and silver amidst shifting central bank policies.  Subscribe to our newsletter: https://riskreversalmedia.beehiiv.com/subscribe — About the Show: On The Tape is a weekly podcast with CNBC Fast Money's Guy Adami, Dan Nathan and Danny Moses. They're offering takes on the biggest market-moving headlines of the week, trade ideas, in-depth analysis, tips and advice. Each episode, they are joined by prominent Wall Street participants to help viewers make smarter investment decisions. Bear market, bull market, recession, inflation or deflation… we're here to help guide your portfolio into the green. Risk Reversal brings you years of experience from former Wall Street insiders trading stocks to experts in the commodity market. — Check out our show notes here See what adding futures can do for you at cmegroup.com/onthetape. — Shoot us an email at OnTheTape@riskreversal.com with any feedback, suggestions, or questions for us to answer on the pod and follow us @OnTheTapePod on Twitter or @riskreversalmedia on Threads — We're on social: Follow @GuyAdami on Twitter Follow Danny Moses @DMoses34 on Twitter Follow Liz Thomas @LizThomasStrat on Twitter Follow us on Instagram @RiskReversalMedia Subscribe to our YouTube page The financial opinions expressed in Risk Reversal content are for information purposes only. The opinions expressed by the hosts and participants are not an attempt to influence specific trading behavior, investments, or strategies. Past performance does not necessarily predict future outcomes. No specific results or profits are assured when relying on Risk Reversal. Before making any investment or trade, evaluate its suitability for your circumstances and consider consulting your own financial or investment advisor. The financial products discussed in Risk Reversal carry a high level of risk and may not be appropriate for many investors. If you have uncertainties, it's advisable to seek professional advice. Remember that trading involves a risk to your capital, so only invest money that you can afford to lose. Derivatives are not suitable for all investors and involve the risk of losing more than the amount originally deposited and any profit you might have made. This communication is not a recommendation or offer to buy, sell or retain any specific investment or service.

Finally Fed makes a move (they will not be done jabbering though) Storms heading to Florida and Gulf Coast - Natural gas prices jump COVID Shot Stocks - "fun" while it lasted Confidence is waning..... CHINA! PLUS we are now on Spotify and Amazon Music/Podcasts! Click HERE for Show Notes and Links DHUnplugged is now streaming live - with listener chat. Click on link on the right sidebar. Love the Show? Then how about a Donation? Follow John C. Dvorak on Twitter Follow Andrew Horowitz on Twitter DONATIONS ? Warm-Up - Finally Fed makes a move (they will not be done jabbering though) - Storms heading to Florida and Gulf Coast - Natural gas prices jump - COVID Stocks - "fun" while it lasted - Confidence is waning..... - CHINA! Bazooka Time! Markets - All-Time Highs - Same saying Goldilocks conditions - Seasonality favors the bulls starting next quarter - Uranium starting to move as people warming up to nuclear energy again - Trump Stock on the move Need to Pick a new CTP Exile - A leading economist in China has vanished following critical comments about President Xi Jinping‘s economic policies. - What Happened: Zhu Hengpeng, deputy director at the Chinese Academy of Social Sciences (CASS), was detained after allegedly criticizing Xi in a private WeChat group. Zhu's remarks reportedly included veiled criticisms of Xi's leadership and comments on China's struggling economy, reported The Wall Street Journal on Tuesday. - The investigation into Zhu coincides with the Chinese Communist Party's intensified efforts to suppress negative commentary about the country's economic health. Under Xi, dissent has been increasingly punished, with critics facing imprisonment or exile. - AH would be have cement shoes if this happened in the USA On The Other Hand - CHINA PROP IT UP - China said it will allow institutional investors to tap central bank financing for stock purchases and is weighing plans for a market stabilization fund, sparking the biggest rally since 2020 for the nation's beaten-down equities. - The People's Bank of China will set up a swap facility allowing securities firms, funds and insurance companies to tap liquidity from the central bank to purchase equities - The CSI 300 Index, a benchmark of onshore Chinese stocks, surged 4.3% to cap its best day since July 2020. In Hong Kong, a gauge of Chinese shares was up more than 5% intraday. - MCHI up 8%, FXI up 8.5%, YINN (3X) up 25% M&A FOLLOW UP - Buyout firms Vista Equity Partners and Blackstone are in advanced talks to acquire Smartsheet, in a deal that could value the collaboration-software maker at close to $8 billion, people familiar with the matter said on Monday. - NEWS: Collaboration software maker Smartsheet on Tuesday announced it would be acquired by Blackstone and Vista Equity Partners in an all-cash deal which valued the company at $8.4 billion. THE FED - Cuts rates by 0.50% -- Seems to have been looking to appease markets - Initial reaction was blah... Unwinding of positions put on right before the decision - Next day stocks soared - “The Committee has gained greater confidence that inflation is moving sustainably toward 2 percent, and judges that the risks to achieving its employment and inflation goals are roughly in balance,” the Federal Reserve statement said. - Last time Fed cut rates was COVID days , time before that was Financial Crisis of 2008 - The federal funds rate is now a range between 4.75%-5% Meanwhile - Consumer confidence in September suffers largest decline since August 2021 - The key takeaway from the report is that consumers' views of the current labor market situation continued to soften and became more pessimistic about future labor market conditions -- a sentiment that could weigh on consumer spending activity. ---- The Present Situation Index dropped to 124.3 from an upwardly revised 134.6 (from 134.4) in August.

McDonald's rolling out a new low-priced meal as cash-strapped customers tighten their purse strings. The latest signs of the consumer crunch, and the sentiment at its lowest level of the year. Plus China stocks rebound. Mainland momentum picking up, as China's FXI outperform the S&P 500 this year. How the overseas opportunities could help boost your portfolio. Fast Money Disclaimer

Dan Nathan, Guy Adami and Carter Worth break down the top market headlines and bring you stock market trade ideas for Thursday, January 25th Timecodes 0:00 - Tesla Down, IBM Up 11:00 - SPX 12:20 - Carter Charts The SMH 16:00 - GDX 17:45 - Next Week's Action 24:30 - Small Caps 31:00 - $FXI, $BABA 36:00 - GDP & Yields 38:00 - Earnings Insight -- Subscribe to our newsletter: https://riskreversalmedia.beehiiv.com/subscribe MRKT Call is brought to you by our presenting sponsors CME Group, FactSet & SoFi Watch MRKT Call LIVE at 1pm M-TH on YouTube Sign up for our emails Follow us on Twitter @MRKTCall Follow @GuyAdami on Twitter Follow @CarterBWorth on Twitter Follow us on Instagram @RiskReversalMedia Like us on Facebook @RiskReversal Watch all of our videos on YouTube

Conflicting Data – but absolute certainty. What was in is out – a rotation at the start of the year. The 10-year Treasury tops 4% - for a moment – looking like a key resistance point. And our guest…Sam Burns of Mill Street Research. Sam Burns, CFA is the chief strategist at Mill Street Research – an independent research company specializing in proprietary institutional research tools for asset allocation, stock selection, and macro-economic indicators.  Burns has more than 20 years of experience as a market strategist providing US and global investment insights at Wall Street firms including Oppenheimer & Co., Brown Brothers Harriman, State Street Global Markets, and Ned Davis Research. Mill Street Research: Mill Street Research provides a suite of consistently updated research reports and data for institutional investors covering asset allocation, country allocation, sector, and industry selection, equity factor analysis, and a robust quantitative stock selection process. The firm publishes more than eight research pieces each month to update investors on the various models and provide commentary on the current market and economic trends. You can find Sam Burns & Mill Street Research at https://www.millstreetresearch.com/ and on Twitter at @MillStResearch. Check this out and find out more at: http://www.interactivebrokers.com/ Follow @andrewhorowitz Looking for style diversification? More information on the TDI Managed Growth Strategy - HERE Stocks mentioned in this episode: (SMH), (OIL), (MCHI), (FXI), (SPY)

In this compelling episode of The Money Exchange Podcast, join host Patrina Dixon as she delves into the world of professional development and career advancement with Lee Crockett, MBA, an esteemed executive and career coach. With over a decade of leadership experience in top-tier companies like Frito-Lay, Nestle, and FXI, Lee Crockett is on a mission to empower high-achieving professional women.   Lee shares her journey of founding Lee Crockett Consulting, an avenue where she harnesses her expertise in sales, strategy, and professional development to propel women towards success. Her focus is crystal clear: enabling women to claim the titles and compensation they rightly deserve by navigating the obstacles of imposter syndrome, fast-tracking promotions, and seizing control of their careers.   Throughout the episode, Lee imparts invaluable insights and strategies for women aspiring to break through the glass ceiling. She explores the nuances of leadership, overcoming challenges, and the critical importance of mentorship in achieving career aspirations. Her passion and dedication to fostering a more inclusive corporate landscape shine through as she discusses ways to create a seat at the table and navigate the complexities of career growth.   Join Patrina Dixon and Lee Crockett in this engaging conversation that aims to inspire and equip women with the tools and mindset needed to thrive in the competitive corporate world. Tune in for a dynamic discussion filled with actionable advice, empowering anecdotes, and a roadmap towards mastering professional growth as a woman in today's corporate landscape.   Resources   Master Being An Affiliate   https://millionairemindset01.gumroad.com/l/PDSRF?autocomplete=true&layout=discover&query=master+being+affili&recommended_by=search&_gl=1*10wx3v9*_ga*NzA3NTYzMS4xNzAwMjQyNTg4*_ga_6LJN6D94N6*MTcwMDUwNzc5Mi4zLjEuMTcwMDUwNzc5Mi4wLjAuMA..    Sign Up for The Newsletter  http://eepurl.com/c8pAbz     Connect with the host, Patrina Dixon   +Instagram https://www.instagram.com/itsmymoney_/    +Facebook https://www.facebook.com/profile.php?id=100013355082005    +Twitter https://twitter.com/itsmymoney_    +YouTube https://youtube.com/c/It%E2%80%99sMyMoneywithPatrinaDixon    +Pinterest https://pin.it/5x8rOTp    +Website http://www.itsmymoneyjournal.info/  Connect with guest Lee Crockett   +Instagram   https://www.instagram.com/leeacrockett/    +LinkedIn   https://www.linkedin.com/in/lee-crockett-mba/    +Facebook   https://www.facebook.com/leeannecrockett    +Twitter   https://twitter.com/LeeACrockett   

This week we feature a preview of the week ahead and coverage of the Diamond Sports chapter 11 filing, Silicon Valley Bank, Signature Bank and other regional banks, potential restructurings and refinancings on the horizon from WeWork, Diebold, Audacy and FXI. We also discuss litigation related to Serta Simmons and Mitel Networks and the first hearing held by the newly formed House Financial Services Subcommittee on Digital Assets, Financial Technology and Inclusion. 00:25 - Weekly recap 07:17 - Week's top-read stories 07:51 - Week ahead preview We're looking for feedback to improve the podcast experience! Please share your thoughts here: www.research.net/r/Reorg_podcast_survey #leveragedfinance #highyield #chapter11 #refinancing #restructuring #distresseddebt #performingcredit

Financials reporting - mixed results. All much worse than a year ago.The HOPE trade is looking for a kindlier and gentler Fed. China has an interesting update on their population. Yield Curve inversion is real - pay attention. PLUS we are now on Spotify and Amazon Music/Podcasts! Click HERE for Show Notes and Links DHUnplugged is now streaming live - with listener chat. Click on link on the right sidebar. Love the Show? Then how about a Donation? Follow John C. Dvorak on Twitter Follow Andrew Horowitz on Twitter Warm Up - Market in Rally Mode - Climate Change at Davos, ESG defended (should be defunded) - China releases population studies - Mega Million > $1.35 Billion (ONE WINNER!) - Biden classified docs - wow,  unforced error there. Market Update - Quick Check - January 2023 - SP500 +4.2%, TLT +7.22%, QQQ +7%, EEM 9%, BTC +28%, FXI +13.5%, GLD +5% - USD Basket 2023 Down 1%, 3 Months - 9% - Bank earnings - mixed, watching for margins and outlook for remainder - Bond yields pricing in easier Fed - 10Y @ 3.5% - EU hints on slowing rate hikes - maybe only 0.25% at next meeting. Deflation Talk ? Commodity Prices Housing Deflation? Housing Prices (CS20) AH Tweet:  - If you were wondering - not just a flash in the pan occurrence. Yield curve clearly and definitively inverted. Will discuss tomorrow night on DHUnplugged Podcast. Inversion Speaking of the USD - Morgan Stanley cut its 2023 year-end forecast for the dollar index to 98, and expects the greenback's weakness to be more pronounced against the euro this year as worries about the severity of an economic downturn start to ease. - They previously saw the index , which weighs the U.S. currency against a basket of six major rivals, ending 2023 at 104. - Global growth is showing signs of buoyancy, macro and inflation uncertainty are waning and the USD is rapidly losing its carry advantage USD Weakness? Change in Central Bank Policy? Bond Vigilantes attack - Yields on Japan's benchmark 10-year government bonds breached the central bank's new ceiling on Friday in the market's most direct challenge yet to decades of uber-easy monetary policy. - A wall of selling catapulted 10-year Japanese government bond yields 4 basis points higher to 0.54%, the highest since mid-2015 and above a recently widened band of -0.5% to +0.5% set by the BOJ in a shock decision just a few weeks ago. - No more negative yields - anywhere in the world ----- This is where it gets interesting - The stress was evident across the yield curve and defied the BOJ's announcement on Friday of a fresh round of emergency buying worth around 1.4 trillion yen ($10.84 billion), when it already holds 80% to 90% of some bond lines. --- BOJ owns more than 50% of all bonds issued from Japan (Eating your own arm because you are hungry) Europe Off The Hook for Deep Recession? - Europe experienced its second-warmest year on record in 2022, European Union scientists said on Tuesday, as climate change unleashed record-breaking weather extremes that slashed crop yields, dried up rivers and led to thousands of deaths. - This was big concern due to Nat Gas Pricing and Oil (Russia related) - - Now said that Europe may not enter recession.... ---- In other words, they have no idea as early in the Winter and anything can happen - but betting warm conditions continue? Back to Davos - Climate activists protested in Davos on Sunday against the role of big oil firms at this week's World Economic Forum (WEF), saying they were hijacking the climate debate. (In other words, they are disagreeing with Climate activists and they don't like that) - And here who is saying this: "We are demanding concrete and real climate action," said Nicolas Siegrist, the 26-year old organiser of the protest who also heads the Young Socialists party in Switzerland. - With ESG crapola under scrutiny - there is an opening here

Dan Nathan and Guy Adami discuss the top market headlines for Tuesday, January 10th -The guys take stock of the $SPX & $NDX in the face of inflation warnings and Thursday's CPI -Dogs of the Dow ain't got Fleas $INTC $CRM $DIS -Dan's bearish $FXI options trade MRKT Call is brought to you by our presenting sponsors CME Group, FactSet & SoFi Watch MRKT Call LIVE at 1pm M-TH on YouTube Sign up for our emails Follow us on Twitter @MRKTCall Follow Dan Nathan @RiskReversal on Twitter Follow @GuyAdami on Twitter Follow @CarterBWorth on Twitter Follow us on Instagram @RiskReversalMedia Like us on Facebook @RiskReversal Watch all of our videos on YouTube

Dan Nathan and Guy Adami discuss the top market headlines for Tuesday, January 10th -The guys take stock of the $SPX & $NDX in the face of inflation warnings and Thursday's CPI -Dogs of the Dow ain't got Fleas $INTC $CRM $DIS -Dan's bearish $FXI options trade MRKT Call is brought to you by our presenting sponsors CME Group, FactSet & SoFi Watch MRKT Call LIVE at 1pm M-TH on YouTube Sign up for our emails Follow us on Twitter @MRKTCall Follow Dan Nathan @RiskReversal on Twitter Follow @GuyAdami on Twitter Follow @CarterBWorth on Twitter Follow us on Instagram @RiskReversalMedia Like us on Facebook @RiskReversal Watch all of our videos on YouTube

UK PM Truss Quits post 6 weeks $6B_F ready to reload short @hfrfromthefloor says Take Under @NFL and China housing Vacancy glaring $FXI shows economy Crumbling $TSLA holding $200 barely post earnings $TNX new highs 4.2% $UB_F $ZB_F keeps selling $MRNA $PFE https://twitter.com/i/broadcasts/1mrGmkdAdVdxy

TimingResearch.com Crowd Forecast News Episode #350, recorded at 1PM ET on July 11th, 2022. The full video, timeline, special offers, and show notes available here: https://timingresearch.com/blog/2022/crowd-forecast-news-episode-350/   Highlights: • S&P 500 / $SPX / $SPY projections for the week. • Other symbols discussed: $EUFN, $FXI, $AAPL, $META, $KWEB, and more!   Lineup for this Episode: - Sunny Harris of MoneyMentor.com - Simon Klein of TradeSmart4x.com - The Option Professor of OptionProfessor.com (moderator)   Terms and Policies: https://timingresearch.com/policies/  

TimingResearch.com Crowd Forecast News Episode #346, recorded at 1PM ET on June 13th, 2022. The full video, timeline, special offers, and show notes available here: https://timingresearch.com/blog/2022/crowd-forecast-news-episode-346/   Highlights: • S&P 500 / $SPX / $SPY projections for the week. • Sunny and Jim's favorite indicators and strategies. • Other symbols discussed: $SMH, $GLD, $XLB, $TLT, $KWEB, $FXI, $RRC, and more!   Lineup for this Episode: - Sunny Harris of MoneyMentor.com - The Option Professor of OptionProfessor.com (moderator)   Terms and Policies: https://timingresearch.com/policies/  

Interest in FXI, like to buy GARPy software on the dips

TimingResearch.com Crowd Forecast News Episode #345, recorded at 1PM ET on June 6th, 2022. The full video, timeline, special offers, and show notes available here: https://timingresearch.com/blog/2022/crowd-forecast-news-episode-345/   Highlights: • S&P 500 / $SPX / $SPY projections for the week. • Simon and Sunny's favorite trading indicators. • Other symbols discussed: $USDJPY, $FXI, $KWEB, $LVS, $DIDI, $XLE, $ADM, $CF, $MOS, and more!   Lineup for this Episode: - Simon Klein of TradeSmart4x.com - Sunny Harris of MoneyMentor.com - The Option Professor of OptionProfessor.com (moderator)   Terms and Policies: https://timingresearch.com/policies/  

Hello everybody, our guest today is Brian Lund, a fintech executive, investor, and writer with over 35 years of trading experience. Brian is the publisher of The Lund Loop, a weekly newsletter in which he writes about the intersection between markets, trading, and life. In this special live episode of Smarter Trading, host Evan Medeiros and special guest Brian Lund, are on camera, sharing their screens, chatting about the current market environment, trade opportunities, and the psychology of market sell offs. ----- This episode is sponsored by Investor’s Business Daily. IBD has helped investors navigate every market cycle with their time-tested methodology for over 35 years. Right now Smarter Trading podcast listeners can get their first 2 months of IBD Digital, a subscription service that gives you access to IBD’s proprietary market analysis and top trade ideas for only $20 by signing up at investors.com/evan. ----- What you'll learn in this episode 0:00 Stream waiting0:39 Introduction3:40 Putting the current correction into context6:20 Diving into the technicals of the current market10:10 Measuring social sentiment15:00 Trading futures and balancing reward versus stress ratio18:50 Crypto trading, infrastructure risks, & risk management25:00 Pot stocks overview: charts, technicals, and industry34:30 Trading the defensive areas of the market36:50 Shorting the market and finding bearish bets44:50 Relief rally; what the Fed is doing; fundamental data49:40 Chart analysis: EEM, FXI, & PINS52:40 Distorted valuations and anchoring on prior price levels ----- Connect with Evan & Trade Risk Browse the entire Smarter Trading podcast catalog Watch this episode in video on our YouTube channel Follow @evanmedeiros on Twitter Follow @TheTradeRisk on Twitter Join the Trade Risk's weekly newsletter ----- If you enjoyed this week's episode, we would really appreciate a rating and review on Apple Podcasts so that we can reach more traders and bring on more great guests.

Markets ($SPY, $QQQ) are attempting a rebound after a two-day selloff, but will it last? @jermalchandler takes a look at option flow in $STLD, $GM, $FXI and $AA. Also examining online sports bettors favorite sportsbook sites. Tune in!

Markets ($SPY, $QQQ) are attempting a rebound after a two-day selloff, but will it last? @jermalchandler takes a look at option flow in $STLD, $GM, $FXI and $AA. Also examining online sports bettors favorite sportsbook sites. Tune in!

Initial jobless claims fall to the lowest in five decades, but is it real? It would seem that traders has lost their (risk) appetite for BTC. And Jermal asks why TSLA and ARKK on different sides of the map. Featured option flows: ROKU, FXI, CHWY and SFIX

Initial jobless claims fall to the lowest in five decades, but is it real? It would seem that traders has lost their (risk) appetite for BTC. And Jermal asks why TSLA and ARKK on different sides of the map. Featured option flows: ROKU, FXI, CHWY and SFIX

L'approccio top-down negli investimenti per trovare i Paesi e le economie con più vantaggio statistico.Bitcoin ed Ethereum a nuovi massimi storici, così come gli indici azionari americani. Dati macro mostrano come il PPI potrebbe ancora continuare il suo rialzo, traducendosi in una possibile spinta inflazionistica maggiore.00:00 Introduzione alla puntata di oggi  01:37 Attenzione a saper controllare le emozioni nel trading02:43 Dati della settimana, cosa monitoro?04:02 Come si sta muovendo il CPI dei vari paesi 04:20 Aumenta lo Spread, cosa può succedere? 06:00 I vantaggi dell'approccio top-down06:55 Come crearsi un vantaggio statistico sul mercato con l'analisi macro10:52 Avere un processo di trading è fondamentale12:31 Quali paesi stanno offrendo le migliori opportunità? 16:30 Come utilizzo il COT Report17:26 Cosa ci sta indicando il COT, le posizioni dei non-commercial21:40 ZEW Economic sentiment Germania in recupero22:19 Update dati macro 24:07 Analisi su FXI 25:00 Quali sono i volumi delle Opzioni PUT/CALL 25:26 Baltic Dry Index, discesa inarrestabile?26:17 Quali performance hanno fatto i vari paesi?27:58 Piano Infrastrutture di BIden approvato, come reagisce il mercato equity29:36 Q&A “Cosa sta facendo l'Uranio?  Può salire vista la politica globale green?”32:59 Saluti finali 

Liz and Jenny close their /SPRE vs gold pair, add a new November position in FXI, and look at a short call spread in BABA.Featured Symbols: /SPRE, GOLD, BABA, FXI

Liz and Jenny close their /SPRE vs gold pair, add a new November position in FXI, and look at a short call spread in BABA.Featured Symbols: /SPRE, GOLD, BABA, FXI

Welcome all once again. The stock market keeps pushing up. IWM is bouncing off the bottom of the range. EWZ and EWW are looking for support. The energy sector pushing retreats to the downside. Oil tested lows and looking to find support. XOP and XLE pull back. SMH broke the top of the range and comes back in. FXI and EEM are basing out for a move-up. Become a Patron!">Join Trade Doc Patreon for move videos and trades. https://www.patreon.com/TradeDoc --- Send in a voice message: https://anchor.fm/tradedoc/message

Welcome all once again. The stock market pushes up late last week. IWM is still in the middle of the range. EWZ and EWW in reversal mode. The energy sector pushing up slowly. Oil tested lows and holding its strength. XOP and XLE are looking bullish. SMH broke the top of the range. FXI and EEM are basing out for a move up. Become a Patron!">Join Trade Doc Patreon for move videos and trades. https://www.patreon.com/TradeDoc --- Send in a voice message: https://anchor.fm/tradedoc/message

Good news, bad new - earnings season provides insights. Covid worries dominate the tape. The Fed digs in and stays put. Thinking hard about complacency levels and what to do now. Join clients from over 200 countries and territories to invest globally in Stocks, Options, Futures, Forex, Bonds and Funds from a single integrated account at the lowest cost at IBKR.com Learn More at http://www.ibkr.com/ Follow @andrewhorowitz Looking for style diversification? More information on the TDI Managed Growth Strategy - https://thedisciplinedinvestor.com/blog/tdi-strategy/ eNVESTOLOGY Info - https://envestology.com/ Friday Pre-Market Run-Down Webinar Registration - https://www.triggercharts.com/webinar-pre-market-rundown-fridays/ Stocks mentioned in this episode: (DIDI), (FXI), (AMZN), (CROX), (BABA), (SPY), (IWM)

ROLL IT, HOLD IT, CLOSE IT!! IT is 21 Days until expiration and it is time to open each position and make decisions. Featured symbols in: AA, AAPL, ASTR, BABA, BODY, CCL, CLOV,CVS, DM, DONUT, DVN, EEM, FXI, GPS, & INTC

ROLL IT, HOLD IT, CLOSE IT!! IT is 21 Days until expiration and it is time to open each position and make decisions. Featured symbols in: AA, AAPL, ASTR, BABA, BODY, CCL, CLOV,CVS, DM, DONUT, DVN, EEM, FXI, GPS, & INTC

Liz brings up a discussion from Sunday night's show about a China/SPY pairs trade. The gals get long FXI and use a Small Exchange product to size down a small SPY position. Featured Symbols: FXI, SPY, /SM75, C, DAL, WFC

Liz brings up a discussion from Sunday night's show about a China/SPY pairs trade. The gals get long FXI and use a Small Exchange product to size down a small SPY position. Featured Symbols: FXI, SPY, /SM75, C, DAL, WFC

Liz and Jenny take live tweets on trade ideas. They look at ETFs with high IVRs and trade SPCE as a binary event.  Featured symbols include: NEGG, KWEB, EEM, FXI, EWZ,VIX, & SPX

Liz and Jenny take live tweets on trade ideas. They look at ETFs with high IVRs and trade SPCE as a binary event.  Featured symbols include: NEGG, KWEB, EEM, FXI, EWZ,VIX, & SPX

Welcome all once again. The stock market pushes up late last week. IWM hit the top of the channel and remain there for a possible breakout. EWZ in pull-back mode. Formed a short-term double top. The energy sector pushing up slowly. Oil is holding its strength. RSX and INDA in consolidation mode. EEM, FXI and XBI are looking bullish. Look out for a new podcast. Crypto Weekend with Trade Doc debuting next Saturday. View this episode's video on my Youtube channel below. https://www.youtube.com/channel/UCNI13o7mV_LzcjFAXUgC9Iw https://www.theta.tv/tradedoc --- Send in a voice message: https://anchor.fm/tradedoc/message Support this podcast: https://anchor.fm/tradedoc/support

Today's Topics:Trading Carbon Credits?!Tell me why I shouldn't buy Tech and Commodities.Yield curve gets stomped out.Goldman does more bitcoin & Miami pitches miners.$FXI a green shoot in a sea of $SPY red.

Today's Topics:Trading Carbon Credits?!Tell me why I shouldn't buy Tech and Commodities.Yield curve gets stomped out.Goldman does more bitcoin & Miami pitches miners.$FXI a green shoot in a sea of $SPY red.

Welcome all once again. Markets continue to lose volatility at the end of the week. SPY hitting all time highs. FXI and EEM propping up for a trend change. Bullish: EWW, EWZ, RSX, INDA Bearish: TLT, XLV --- Send in a voice message: https://anchor.fm/tradedoc/message

Welcome all once again. Markets volatile at the end of the week. SPY holding on to the 412 area into 415 INDA and RSX are holding. FXI and EEM slide down. Bullish: EWW, EWZ, RSX, INDA Bearish: TLT, XLV --- Send in a voice message: https://anchor.fm/tradedoc/message

In this episode of the IoT For All Podcast, Centrak President and CEO David Minning joins us to talk about IoT’s role in the healthcare space, both during the COVID-19 pandemic and beyond. David shares his expertise on some of the technologies used in healthcare today, like RTLS, some of the challenges IoT faces in healthcare, and where it’s going from here.David Minning brings more than 30 years of healthcare experience to his role as CenTrak’s President and CEO. Prior to joining CenTrak, Minning served in leadership positions as President and CEO at Bio-Chem Fluidics; Executive Vice President and Chief Commercial Officer at FXI; and Vice President of Marketing and Innovation at Hillrom. He holds an MBA from the University of Cincinnati.Interested in connecting with David? Reach out to him on Linkedin!About Centrak: CenTrak has been a market leader in IoT-based locating, sensing, and security services for the healthcare industry since 2007. Named a visionary in the Gartner Magic Quadrant for indoor location services, CenTrak helps healthcare leaders across the globe increase productivity, reduce operating costs, and drive patient and staff satisfaction.Key Questions and Topics from this Episode:(00:32) Intro to David Minning(02:00) How have you seen COVID-19 affect the market for Centrak?(03:02) Intro to Centrak(06:17) Where do you see IoT’s role evolving in healthcare?(08:24) What is RTLS and what benefits does it enable in hospital settings?(10:23) What challenges do you encounter, implementing these solutions in medical or hospital settings?(12:09) Have these technologies helped hospitals bridge the gap during the pandemic? (14:05) If a company is looking to partner with providers offering single-source solutions, what should they be considering? What are the advantages of choosing a partner with a more focused solution?(21:00) What are some challenges listeners might not have thought about as they start their IoT journey? What’s your advice for approaching that process?(23:46) What are your predictions for the healthcare space, RTLS, and the IoT landscape for 2021?

Election tension is heating up and there is increased speculation regarding the potential victor. As a result, certain sectors have been going crazy, both up and down. Tillie Allison-Harris joins me to look at how she is setting up for the election and offer some accumulation and distribution zones she has identified on market indexes. We will begin live at 2pm PST today and send in your questions!  

Show notes: http://optionalpha.com/show184Adjusting trades that move against you can be hard enough. Choosing how to adjust and when to pull the trigger complicates what otherwise was a simple trade to start with. Now, throw in an early assignment to the mix and you've got quite the convoluted option trade on your hands. Sounds daunting already doesn't it? But fear not. Complicated and complex trades like the one that happened to us in FXI the other month give you a great opportunity to learn and grow as a trader. On today's show, we'll walk through the entire FXI position from start to finish, including all the profit and loss calculations including adjustments and an early assignment. Lean into this show and don't skip it - your future self with thank you for taking the time now so that you don't have to freak out later when it happens to you.

Welcome all once again. Markets volatile at the end of the week. SPY holding on to the 285 area into 300 INDA,RSX and OIH and holding. FXI and XOP slide down. Bullish: EWW, EWZ, RSX, INDA Bearish: TLT, XLV, UUP --- Send in a voice message: https://anchor.fm/tradedoc/message

TheImpervious and I speculate on Monday (5/4/2020) and beyond's action in light of last week's earnings news and the Oracle's decision to sell down all of Berkshire's airlines positions. Sean shares some options plays on $CVS, $DIS, and the airlines. We discuss escalations in China - U.S. tensions and what it could mean for equities (as well as a successful $FXI trade we both executed). We finish off with Sean's top trading ideas and recommendations on entry and exit identification, position sizing and risk management.

Welcome everyone Last week there were a few earnings on big names, most reported beats on estimates. This week we have many more earnings that will dictate the direction of the markets. FXI and EEM caught some bids late in the week. Hopefully the situation will remedy itself. Good luck this week --- Send in a voice message: https://anchor.fm/tradedoc/message

Welcome everyone. This week the markets react to the spread of the virus and don't put in new all time highs. Oil markets keep getting sold off. FXI drops and scramble to hold markets up. Good luck, see you next week. --- Send in a voice message: https://anchor.fm/tradedoc/message

Welcome all once again. EWZ adn FXI markets are retracing to find prices. Christmas around the corner for XRT. Shorting pigs this week. Good luck. --- Send in a voice message: https://anchor.fm/tradedoc/message

Welcome once again. Looking for look positions in MJ, FXI, and EEM Markets look stable. Even oil has to bounce. Good luck Thank you for the support. --- Send in a voice message: https://anchor.fm/tradedoc/message

Thank you all for joining me once again. Today we discuss the return of volatility to the markets. The Markets didn't like the fake cut rates by .25%. oil markets took a hit as well as the Emerging Markets especially China and Mexico, FXI & EWW. make sure your trades are small this week. And look for Steep replacements to get long. Going half cash is not a bad idea. Which out for those dividend paying ETFs. Good luck all this week feel free to get in touch. --- Send in a voice message: https://anchor.fm/tradedoc/message

Welcome all. The markets have made their goals of touching all time highs but where do we go from here? RSX scraping the tops and inching newe highs. FXI ready to push up and see how high it can maintain. INDA based out for next move up. MJ tanks on a flush. could cause a V bottom. Looking for consolidation for the rest of the year. --- Send in a voice message: https://anchor.fm/tradedoc/message

Welcome to another week. Long on XME, XRT and FXI for strong bounces. Patient on XOP, GLD, GDX shorts. Caution on Tech and QQQ. Equal weight tech is better to role with, RYT. Hold on to your shorts. Summer time is coming. --- Send in a voice message: https://anchor.fm/tradedoc/message

Welcome all. Today discussed idea on trade wars and how to trade. What may be happening between China, Russsia and India? Do they need our deals and what it means to us. Markets have been consolidating and the trigger that can cause the next move up would be the settlement of the trade deals. I'm long INDA, FXI, EWZ and IWM Short USO, XLB and short term short XLK Neutral the broad markets along with UXVY. Thank you and Good luck. --- Send in a voice message: https://anchor.fm/tradedoc/message

Feeling a little crypto fomo. Over view or consolidation to bullish bias on the markets. Opened positions in UVXY, FXI, INDA, and EEM. For bullish consolidation. EWZ has touch an important support level --- Send in a voice message: https://anchor.fm/tradedoc/message

Welcome everyone. Markets are in consolidation mode with some bullish probabilities. Oil is ready to move one way or another but will it be believable? FXI and INDA will see one more leg down before finding support. IYR looking to retest the tops XBI and MJ find support at current levels. --- Send in a voice message: https://anchor.fm/tradedoc/message

Thank you all for Joining me Spoke about the positions built on MJ ETF. Oil drops but XOP looks like it could bounce. GLD and GDX on the watch. HOt ETFs: EEM, EWW, FXI, XBI, XLV, INDA, MJ --- Send in a voice message: https://anchor.fm/tradedoc/message

Thank you all for joining me and Happy Easter. Check out the strength in FXI, INDA, and RSX. EEM, EWZ and EWW keeping positive delta. XLB and XLI my be topping out. Looking to buy the dip in XLV, XBI, MJ, and PPH The rest of the markets looks like they will consolidate withing the 2 week ranges. Volatility should come up to make a traders market for the week. --- Send in a voice message: https://anchor.fm/tradedoc/message

Another bullish week in the books. Stocks look like they are set up to fly, But Proceed with caution. Got MJ and EWW ready to break out and fly. FXI, INDA, and RSX are in consolidation mode and inching higher. Keep and eye on that USO and XOP for a retrace. Its now a traders market so go get 'em. --- Send in a voice message: https://anchor.fm/tradedoc/message

Thank you all for joining me. Today we spoke about: We discussed trades put on EWZ, and XLF Some potential set ups in XLV, XHB, XBI, XRT, and RSX The current Broad 28 Watch list of ETFs are liquid and provide options for great position controls: USO, XOP, GLD, GDX, XLE, XLU, XLI, XLB, XLV, XBI, MJ, IYR, XHB, XLP, XLY, XRT, XLF, XLK, QQQ, SPY, IWM, FXI, INDA, RSX, EFA, EEM, EWW, EWZ --- Send in a voice message: https://anchor.fm/tradedoc/message

In this episode, I went over the broad 28 ETF's in my watch list. Did this to get a feel for the present market conditions and structures. Many Charts are looking topped out while some show signs of breaking into higher prices. Discussed our position in EWZ, DRIP and retail sector. We discuses some Chinese ETFs: CHIC, CHIM, CHIQ, CHIX, CHII New trades opened on USO, EFA, and GLD The broad 28 are: USO, XOP, UNG. GLD. GDX, SLV, IYR, XLE, XLF, XLI, XLU, XLB, XLV, XBI, XHB, XRT, IWM, DIA,SPY, QQQ, EEM, FXI, EPI, RSX, MJ, EFA, EWZ, EWU --- Send in a voice message: https://anchor.fm/tradedoc/message

In today’s episode we discuss a trade setup in FXI. The original article can be found here: https://moneyandmarkets.com/trading-trade-war-tariffs-options/ --- This episode is sponsored by · Anchor: The easiest way to make a podcast. https://anchor.fm/app

Steve Sears and Michael Martin speak about the fallout from China in the gaming industry, the effect of ESPN and Start Wars on Disney, and volatility. Michael gets Steve's feedback on using long-dated options as surrogate vehicles for investing and Steve discusses what he thinks he and his readership got out of his book.  Stocks discussed ASHR, WYNN, MGM, DIS, VIX, and FXI.

Options Oddities 159: VIX, FXI, HAL   Unusual Activity for April 10, 2015:   Puts trade in The CBOE Volatility Index (VIX) Put and stock trades in iShares FTSE/Xinhua China (FXI) Call fly in Halliburton Co. (HAL)

Option Block 70: The Condor Strikes Back Trading Block:No Euro implosion. Ford moving up, Cisco breaking hearts, and AAPL on a rollercoaster.   Odd Block:  Unusual activity updates in  YHOO, USU, and HK   Xpress Block:  Most actives at OX: SPY, SPX, NLY, QQQQ, AAPL, SLV, GLD, RUT, and FXI.   Interview Block:  Dr. Duke is back.  He and the gang discuss condor strategies, including entry and exit points, adjusting positions, his first steps to implementing condors, and what he's watching int he markets.   Around the Block:  Greece and the Euro.  Cattle...COW. Initial jobless claims, Chicago PMI, and a long weekend coming up.     Items of note.... The first-ever LIVE Option Block episode will tape on Thursday, July 21 starting at 3:30 at the Elephant & Castle at 111 W. Adams Street in Chicago.  Be sure to see what happens behind the scenes when the entire gang gets together in the same room.  It's sure to be memorable. Dr. Duke is presenting a webinar entitled "Adjusting the iron condor in a bear market" this Wednesday, June 29 at 8:30 CDT.  You can visit his website, ParkwoodCapitalLLC.com, for more information. Speaking of webinars....Know Your Options will be presenting a series of Sunday night webinars throughout July.  Check KnowYourOptionsInc.com for more information. Not to be left out, Mark Sebastian is a one-man webinar machine presenting a webinar with VolX on "Understanding and Trading Currency Volatility" on July 12.  You can find more information on the VolX.us website.  The next day, July 13, is his free monthly webinar, and on July 14, he's presenting a webinar with Price Futures Group.  For more details, visit the OptionPit.com website.  Read more: http://www.theoptionsinsider.com/radio/?id=252#ixzz1QbFwCZmC The Options Insider: Your Inside Source For Options Information

Plasma-Kallikrein (PK) ist eine Serinprotease, die als inaktives Zymogen Plasma- Prokallikrein (PPK) in der Leber gebildet und in den Blutstrom sezerniert wird. Dort erfolgt die Konvertierung zum aktiven Enzym im Kontaktphasen-System der Blutgerinnung. Neben der Funktion im Kontakt-System spielt diese Protease sowohl in der Fibrinolyse als auch im Kallikrein-Kinin-System eine zentrale Rolle. Neuere Arbeiten haben gezeigt, dass PPKmRNA auch außerhalb der Leber exprimiert wird. Daraus ist zu schließen, dass dort ebenfalls PPK-Protein gebildet wird und dass diesem extrahepatischen, gewebeständigen PPK bzw. PK spezielle lokale Funktionen zukommen. Dieser Befund bildet die Grundlage dieser Dissertation. Mit dem langfristigen Ziel die physiologische und pathophysiologische Rolle des extrahepatisch gebildeten PPK aufzuklären, sollte in dieser Arbeit zunächst mittels einer quantitativen PCR-Technik (TaqMan) untersucht werden, in welchem Umfang PPK-mRNA und die mRNAs der übrigen Komponenten des Kontaktphasen-Systems in humanen Zellen bzw. Geweben exprimiert werden. Aufgrund dieser Ergebnisse sollte im zweiten Teil der Arbeit untersucht werden, ob bzw. inwieweit das PPK-Gen gewebespezifisch reguliert werden kann. Hierzu sollten die regulatorisch bedeutsamen Regionen des PPK-Gens charakterisiert werden. Mittels der TaqMan-Technologie konnte die PPK-mRNA-Expression in allen untersuchten humanen Geweben quantifiziert werden. In neun Geweben liegt die mRNA-Expression im Vergleich zur Leber zwischen 1 % und 68 % und in sechs Geweben zwischen 0,1 % und 1 %. Diese Ergebnisse sprechen für eine ubiquitäre, aber teils sehr unterschiedliche Expression der PPK-mRNA in humanen Geweben. Die mRNAs von hochmolekularem Kininogen (HK), niedermolekularem Kininogen (LK), Faktor XI (FXI) und Faktor XII (FXII) werden dagegen nur in wenigen Geweben exprimiert. Die Transkripte von HK, LK und FXI findet man außerhalb der Leber nur noch in Nierengewebe in signifikanter Menge, während FXII-mRNA nahezu ausschließlich in der Leber synthetisiert wird. Ein gemeinsames Merkmal aller Transkripte ist, dass sie in Lebergewebe am stärksten expimiert werden. Zellstimulationsversuche mit HepG2-Zellen ergaben, dass die PPK-mRNA-Synthese mittels Lipopolysacchariden (LPS) kurzfristig induziert werden kann, was für eine wesentliche Funktion von PPK bzw. PK bei Entzündungsreaktionen spricht. Im Gegensatz hierzu bewirkt Phorbol-12-myristat-13-acetat (PMA) eine Herabregulation der PPK-Transkription. Untersuchungen zur Stabilität der mRNAs von PPK und dem Haushaltsgen GAPDH mit den Transkriptionsinhibitoren Actinomycin D, α-Amanitin und DRB zeigten, dass die mRNAAbbaurate in HepG2-Zellen vom jeweils eingesetzten Transkriptionsinhibitor abhängt. Bei allen Transkriptionsinhibitoren wurde das PPK-Transkript im Vergleich zu GAPDH deutlich schneller (Faktor 3-5) abgebaut. Dies weist darauf hin, dass die PPK-mRNA-Spiegel in den Zellen durch ständige Neusynthese aufrechterhalten werden, um eine kontinuierliche Produktion von PPK zu gewährleisten. Mittels der RLM-RACE Methode wurden in Leber-, Pankreas-, Nieren- und Testisgewebe die PPK-Transkriptionsstartpunkte (TS) identifiziert. Während in der Leber und im Pankreas nur TSs in Exon 1 des PPK-Gens benutzt werden, findet man in Nieren- und Testisgewebe TSs sowohl in der upstream-Region als auch in Intron 1. Weiterhin wurden in Nierengewebe drei am 5´-Ende verkürzte PPK-Transkripte detektiert, die aufgrund dieser Deletion keine Signalpeptid- Sequenz enthalten und dadurch eine intrazelluläre Lokalisation der entsprechenden PPK-Isoform bedingen. Die Consensussequenz-Analyse für die Transkriptionsinitiation zeigt, dass jedem experimentell ermittelten Transkriptionsstart eine TATA-Box oder/und ein Initiator-Element assoziiert ist. Außerdem konnte durch die RLM-RACE-Analysen die Existenz eines weiteren untranslatierten Exons im 5´-Bereich des PPK-Gens ausgeschlossen werden. Unter Anwendung der Genome Walker Technik wurde die Promotorregion (P-1729) stromaufwärts von Exon 1 kloniert und mittels Reportergen-Studien analysiert. In HepG2-Zellen zeigt dieses Gensegment eindeutig transkriptionsaktivierende Kapazität. Durch die Generierung von neun Verkürzungsvarianten konnten der Core-Promotor (-158 bis +22), Enhancerbereiche (-1675 bis -1494) und Silencerregionen (-1304 bis -674) charakterisiert werden. Die Transkriptionsfaktoren-Analyse ergab, dass bei der Regulation durch die P-1729 Region neben ubiquitär exprimierten auch streng gewebespezifische Transkriptionsfaktoren eine zentrale Rolle spielen. Reportergen-Untersuchungen des Intron-1-Bereichs in HEK 293-Zellen zeigten, dass auch diese Region des PPK-Gens transkriptionsaktivierende Kapazität besitzt. Ebenso zeigt aber auch der P-1729 Bereich in HEK 293-Zellen Promotoraktivität. Somit können innerhalb eines Zelltyps beide Promotorbereiche funktionell aktiv sein, wodurch eine alternative Regulation der PPK-Transkription ermöglicht wird.