Podcasts about mtas

Redefining Affiliate Marketing: Brand + Performance for Maximum Revenue Impact“Affiliate marketing intersects with every part of your marketing stack—PR, influencer, paid search, content—but too often, it operates in a silo. The real opportunity lies in integrating it into your brand and performance strategy from day one. When you align affiliate with your broader media mix and apply smarter measurement, it stops being just a channel and becomes a strategic growth lever.” That's a quote from Lacie Thompson, an executive at New Engen and founder of LT Partners and a sneak peek at today's episode. Welcome to Revenue Boost: A Marketing Podcast. I'm your host, Kerry Curran—Fractional Chief Growth Officer, industry analyst, and relentless advocate for turning marketing into a revenue engine. Each episode, I bring you the strategies, insights, and conversations that will fuel your revenue growth. So search for Revenue Boost in your favorite podcast directory, and hit subscribe to stay ahead of the game.In this episode, we're pulling back the curtain on one of the most misunderstood and under-leveraged growth drivers in your marketing stack: affiliate marketing. In Redefining Affiliate Marketing Brand Performance for Maximum Revenue Impact, I'm joined by Lacie Thompson—founder of LT Partners and now an executive at New Engen, a top-tier performance marketing agency. We'll talk about why affiliate deserves a seat at your media planning table, how to integrate it with your broader marketing strategy, and how smart brands are using data and measurement to unlock serious revenue impact. So stay tuned through the ad, where Lacie shares how you can get smarter about measuring affiliate and truly integrating it into your broader strategy.Let's go.Kerry Curran, RBMA (00:01.23):So welcome, Lacie. Please introduce yourself and share a bit about your background and expertise.Lacie Thompson (00:06.617):Yeah, thanks so much for having me. I'm Lacie Thompson. My background, before I started LT Partners—an affiliate marketing agency—was in affiliate and digital marketing on the brand side.I was very lucky in the early days to have some really great mentors and leaders. After spending about six years on the brand side and then three years at another startup agency, I started LT Partners in September of 2018. We grew very quickly—very organically, I should add—and were acquired by New Engen, which is a digital marketing agency, in June of 2023.Kerry Curran, RBMA (00:53.998):Excellent. Well, we're so glad to have you here. I've always been very impressed with your success—and congratulations on building your own successful company and getting acquired.I know you've been in the industry a long time and have lots of expertise to share with us. So, to start: when you're talking to other senior executives, marketing leaders, CMOs, what's the buzz you're hearing? What are people talking about today—especially when it comes to affiliate and digital marketing?Lacie Thompson (01:27.459):Yeah, thinking of the big picture—what I found really interesting about New Engen is the way they have grown and adapted over the course of their history. New Engen is about eight or nine years old at this point, but initially started as a tech company. They built a hyper-granular bidding model on top of Google and Meta, primarily.Over time, as those platforms introduced their own algorithms, that technology became a little less important. What they realized when they took a step back was—they were an agency. It was the people helping the brands leverage the technology who were actually making a big impact. So over time, New Engen pivoted to become a performance marketing agency. Then, just before the acquisition of LT Partners, what the New Engen leaders were hearing in the market was a need to stop thinking about marketing in silos of brand and performance—and to bring it all together. Because thinking about it more holistically is where a lot of brands are trying to get. We had seen that in Affiliate very early on. That was a big part of our growth and success—this focus on understanding the incremental value of partnerships and working more closely with the ones that were more incremental. For us, that means introducing brands to new audiences. We had been hyper-focused on that in our "channel"—I use that word in quotes, because there's always debate about whether to call it a channel. But we had been doing that for a long time. So, at the same time that New Engen was pivoting toward a digital marketing solution in the space—we had already been doing that for a long time in affiliate. And they didn't have Affiliate as a capability. So it was a really natural coming together, because our thought process around measurement and how to evaluate how different marketing channels and methodologies create value for brands—whether it's within a branding ecosystem or a performance one—was very aligned. And we need to solve and measure for that across everything. So there was just a lot of strong alignment there.Kerry Curran, RBMA (04:11.03):They were so smart to acquire you—for your success, but also to see the potential of integrating an affiliate strategy into their offering. IWhere you and I have discussed in the past, I also grew up in a performance marketing world: SEO, paid search, paid social, programmatic. And the more I learned about affiliate, the more I realized affiliate needs to be part of these conversations. But what we've seen is that it's really hard to get people—especially those who haven't wrapped their head around affiliate—to recognize the importance, value, and potential of it.Lacie Thompson (05:02.073):Yeah, and I think that's what's really fun for me about the channel. Because affiliate, like I said, there's this debate around whether it's a channel or a mechanism. And I think that's part of why it's difficult for some people to wrap their head around it—because you don't have an ad platform with a campaign structure. It's not like you push a button and things change. It's 50% data analytics and deep insights—and 50% interpersonal relationships and business development of sorts.But what's funny about affiliate is it's actually the one channel that really intersects so many different parts of your marketing stack: influencer, PR, even paid search. Some partners have capabilities that fall under other types of marketing channels. But for some reason, over time, there has been this trend of affiliate-only agencies. And this narrative that you need an affiliate agency—and a separate digital or performance marketing agency—and that the two operate in silos. Oftentimes, they're not as closely connected as they could be if everything were handled under one roof.So I find the irony of that really interesting. It's not common to see digital marketing agencies that have affiliate as a core area of subject matter expertise. And obviously, as someone who's spent most of my digital marketing career in affiliate and partnerships, I found New Engen's interest in that really exciting.I think, as we'll probably talk about here, when we think about measurement, and the amount of budget brands allocate to affiliate marketing—it's so small compared to the impact it can have. And it's exciting to be part of a larger organization that has the infrastructure and teams to help us prove that value with advanced measurement.Kerry Curran, RBMA (07:27.022):Yes, definitely. And I'm excited to talk more about measurement. But we forget that, to your point, there still needs to be more buy-in, education, and understanding of affiliate's value among CMOs and senior marketers.As you said, affiliate is so full-funnel—it covers PR, awareness-building (influencer/creator or mass publications), all the way down to the research phase before purchase.It opens the door to strategic opportunities and conversations. But it's the term "affiliate" that tends to trip people up.Lacie Thompson (08:24.889):Yes, just a couple of weeks ago, we were talking to a potential client, and we actually got into the affiliate portion of the conversation by first talking about performance PR and influencers—and the convergence of brand and performance. That really opened their minds more than saying, "We're here to talk about your affiliate marketing program."What was cool in that conversation—as sometimes happens—is you could just see this light go off where people start to realize this isn't the same affiliate channel marketing that was happening 10 years ago. We're not just a bottom-of-funnel ecosystem. We really have to change the nomenclature and the structure of how we reward partners to evolve past that old, negative perception.Lacie Thompson (09:39.651):So I hope—and I've seen—that the industry is shifting. More and more people are talking about it this way. It's evolving, and that's wonderful to see.Kerry Curran, RBMA (09:52.79):Yes, I agree. And I think the more upper-funnel opportunities—really, the awareness placements—are becoming essential. I know for PR agencies, if they want to be in a top publication, they need to have an affiliate practice within their organization or partner with an affiliate agency. That's been driving a lot of the shift. And obviously, nothing's grown faster than influencers and creators. It's about understanding that there's integration and overlap. There's so much potential. And to your point, it's really important to understand that affiliate's not just toolbars or coupons.Lacie Thompson (10:36.559):Right. The cool thing about affiliate marketing is that you're essentially, as a brand, letting other people tell your story for you, right? And that is so much more powerful for consumers—hearing from an influencer, a media publication, or an editor. Especially editorial publications with strong reputations.People have a lot of trust in those voices. They trust them more than they trust the brand. So we're seeing a shift toward leveraging what your partnerships are saying about you in other marketing channels. That's another cool thing about being part of New Engen: figuring out how to take what an influencer or a content partner like Wirecutter is saying and turn that intocontent that gets in front of your audience through other channels. And I think a lot of people now know that performs much better than just the brand talking about itself.Kerry Curran, RBMA (11:46.412):Yes, I definitely think that third-party endorsement—especially from a trusted source—goes so far. Again, that ties back to what you said about affiliate being a brand strategy as well. You've talked about the shift from performance-only to brand-plus-performance integration. Talk more about how you're approaching that within New Engen and what you're seeing with clients or brands you're speaking with today.Lacie Thompson (12:19.993):Yes, I mean, historically, I grew up in the age of performance marketing, right? We had sophisticated MTAs. We were focused on understanding what the right MTA was, and how to tweak it in order to understand performance. But you get to this point where, when you're hyper-focused on trackable KPIs, you become as efficient as you can be—but you're also not scaling. So internally at New Engen, a lot of what we focused on in the early days were DTC startups that scaled very rapidly, hyper-focused on performance marketing. But then, at a certain point, you reach a plateau. And the way brands have historically thought about brand versus performance is: performance has KPIs we hold to—ROAS, CAC, whatever it is. On the brand side, those don't really exist. You're looking at engagement rates and lots of other indicators. As we've seen the two converge, we've needed to come up with better ways to measure the impact across the board. That's led to our belief that the foundation needs to be measurement—specifically, a mindset shift in how you approach it.You can't rely solely on Google Analytics as your source of truth. You can't rely just on your affiliate tracking platform—or even on some of the other channel platforms. So we believe that, to get past the performance plateau and actually grow your brand, you have to rethink how you're investing your dollars.Kerry Curran, RBMA (14:26.38):That is so smart. What I've seen over the years is that MMMs don't include all the channels—not just affiliate. Media mix modeling often only includes paid touchpoints. So it sounds like you've gotten to a point where you're really able to measure the impact. It's not “Here's your affiliate report over here, and here's your separate search, social, programmatic report.” You're really looking at the data together. So talk a bit more about how you've been able to do that.Lacie Thompson (15:02.307):Yes, our SVP of Analytics, Andrew Richardson, is just incredible. His understanding of the whole ecosystem—I really respect it. Because oftentimes, affiliate gets pushed to the side, like the redheaded stepchild. But he actually really understands it. So when he built our MMM approach, everything includes affiliate. But it goes beyond that. It also includes: How are your competitors impacting your ability to grow? If they're spending more on media, that has a negative impact on you. We've done things in our models that account for factors like: Is it an election year, and how might that affect your business? We're also looking at your brick-and-mortar store performance and how your digital spend is affecting it. So it really depends on the business and its model—what components matter, the time of year, and everything else.Lacie Thompson (16:08.943):Every situation is different. So we want to come to the table with a model that makes sense for each brand. What's really cool—and validating for me—is that early on at LT Partners, we built a proprietary platform called Lift. We believed just looking at the data in the tracking platform wasn't enough to optimize your program. We always believed that how much new traffic a partner drives is indicative of their incrementality. So we pull data from Google Analytics, match it with the tracking platform, and we've built insights and tools for our team to use on top of that data. We optimize toward partners who are introducing brands to new audiences. And with Lift, we have benchmarking data that tells us, on average, what percentage of traffic is new from content partners, coupon partners, or even individual partners.When we talk with enterprise brands that have advanced measurement tools like Measured, Rockerbox, or Northbeam, sometimes they share that data with us. And we often see close alignment between the level of new traffic and the level of incrementality these models show. Same thing with our internal MMMs. So, while we look at multiple KPIs, it's validating to see that our focus on new traffic is supported by broader measurement.That means smaller brands don't necessarily have to spend hundreds of thousands of dollars. There are other ways to optimize toward what's incremental and valuable— and it doesn't have to be a massive lift.Kerry Curran, RBMA (18:34.678):Thank you for sharing that, because there are so many data points. We talk about this all the time—how the customer journey is not linear. There are so many touchpoints. They go back and forth. Being able to measure impression data—like where someone read your article or saw your brand but didn't take action until later—is really important. It's a very normal behavior pattern. And being able to still attribute that back to the publisher matters. I remember hearing about brands cutting their affiliate marketing because they couldn't prove it drove incrementality. But there's this larger lift that you're able to see. It just sounds like it's helping brands get smarter and smarter about how they're investing.Lacie Thompson (19:32.163):Yes, there are really a couple of different buckets when it comes to measurement to think about. One is actually being able to measure the impact—which I think requires a few different angles to get the right perspective on whether your affiliate program or any other channel is driving incremental value, and what that value looks like.Then there's another bucket: how do I optimize a program? How do I drive toward creating more incrementality? And those don't have to be the same things. I think sometimes when I talk about new traffic, or first-click attributed revenue versus last-click attributed revenue, people ask, “Oh my gosh, do you think we should be using first-click attributed revenue as our measurement?” And I'm like, no—that's over here. That's a different conversation. I'm talking about what data we need to look at to try to improve what the measurement says over here. And oftentimes, that means trying to grow first-click attributed revenue because that is typically more incremental than last-click.Kerry Curran, RBMA (20:50.476):Yes, and to your point, it's about looking at different data points and getting smarter. And I think the more we've seen analytics become more advanced—tracking more touchpoints—the more correlation we see between the channels and the impact they have on each other. At the end of the day, that's what makes affiliate so incredibly valuable and important.I've talked in the past about getting affiliate a seat at the planning table. When the brand is thinking about how to allocate budgets—TV, display, programmatic, search, social—affiliate needs to be part of that conversation. Within New Engen, you have that natural organizational structure to foster that. But it's still a challenge for a lot of agencies and brands that aren't looking at it that way.It sounds like it comes down to getting smarter about the data you're evaluating and how all those touchpoints are really driving impact.Lacie Thompson (21:57.435):Well, I think that's the problem. You have this conflicting dynamic within the channel: it's traditionally performance-based, and it's optimized on a last-click basis. You're paying your partners based on whether they drive the last click. And then everyone gets mad when the big partners figure out how to get that last click—and they say the channel isn't incremental. Well, maybe that's because you're hyper-focused on bottom-of-funnel, spend efficiency, and you're not thinking about partnerships strategically. You're not thinking about how to grow the channel or how to measure it appropriately to understand the impact.The last-click performance nature of the channel will never allow you to fully reward the right partners. It will never allow you to fully understand the value of those partners. So, the actual construct of the channel is in conflict with it having a greater impact on your business.Some marketing leaders just say, “I'm going to let it do its thing, be super efficient, and not pay attention to it.” But I think that's a huge miss. When you think about your holistic approach and how to grow your brand, a lot of people say, “Well, it's so small. It's only 10% of my spend.”Well, it could be 15% of your spend—but have twice as much impact—if you thought about doing it differently.Kerry Curran, RBMA (23:28.942):Yes, and that spend is purely attributable. It's usually a commission—or a cost-per-acquisition model—so it's not like other channels where you're spending millions of dollars and may never know the outcome. So, there's still a lot of education that needs to happen. But the brands you work with are lucky to have you out there helping them get smarter. So, thank you. For the people listening who are thinking, “I need to get smarter about this”—what are some of the readiness steps or foundational things they should have in place to better measure affiliate and integrate it into their broader strategy?Lacie Thompson (24:26.095):I think the first step is really just making sure everything is set up properly. Do you have your UTMs set up—assuming you're using GA, which most people are? Some people use Adobe or other sources of truth, but most still have GA.There are obviously nuances and other ways to do it, but in general, you should make sure that your UTMs are structured appropriately within your affiliate program so everything flows into Google Analytics in a way that lets you match it up with your platform data.Otherwise, you're missing visibility into traffic driven by partner—relative to one another. You might also miss out on more advanced attribution models. That's the foundation to build on top of if you want to optimize your partnerships more thoughtfully.It's also very important to have that data available to share with the partners. Publishers don't know how much new traffic they're sending you. They don't get that feedback loop. The way we think about the data isn't just for internal use—we want to share it.We want to show partners the KPIs that are most valuable to the brand and ask: What can we do together to improve these metrics? If you give them that information, many partners are creative and clever and can come up with great solutions.But a lot of them have been trained to focus on the last click, maybe a higher conversion rate or AOV. And that training does a disservice to the partnership if you're not giving them better insight—and helping them succeed in ways that also help you.Kerry Curran, RBMA (26:36.182):Yes, definitely. To your point, all of it helps companies and brands drive better results and outcomes. So it's about having the right data—and doing smarter things with it.So thank you so much, Lacie. How can people find you?Lacie Thompson (26:52.731):I feel like I'm everywhere! I'm on LinkedIn, you can email me, text me—I'm always available to chat. I'm always happy to help. I love finding ways to improve the industry holistically.I'm happy to give advice—or I love hearing what other people are doing that's cool and unique and special. I love collaborating with other brands. I'm one of those people who doesn't really say no to talking about anything, anytime.You never know where conversations might lead, so please reach out if you want to chat.Kerry Curran, RBMA (27:41.73):Definitely. Well, thank you. I'll be sure to include all that information in the show notes. I really appreciate your time. I've enjoyed our conversation and look forward to having you on again in the future. Thanks, Lacie.Lacie Thompson (27:53.859):Amazing. Thank you so much, Kerry.Kerry Curran, RBMA Thanks for tuning in to Revenue Boost: a Marketing Podcast. I hope today's conversation sparked some new ideas and challenged the way you think about affiliate performance and full funnel growth.If you're serious about turning marketing into a true revenue driver, this is just the beginning. We've got more insightful conversations, expert guests and actionable strategies coming your way. So search for us in your favorite podcast directory and hit subscribe. And hey, if this episode gave you value, share it with a colleague and leave a quick review. It helps more revenue minded leaders like you find our show.Until next time, I'm Kerry Curran, helping you connect marketing to growth, one episode at a time. We'll see you soon.

Joining Stephanie K and Jay In the the studio this week is the MTAs very own Dennis Hershberger!  Our Friends of Transportation golf outing got rained out in June and it's now scheduled for July 22nd!  

In the studio this week is the MTAs very own CEO Mr. Ed Benning.  Mr. Benning is here to talk about what's happening at the MTA.  

This episode originally aired in April 2020 on the "Massage Therapy Without Borders" podcast.COVID-19 has affected many industries around the world, Massage Therapy being one of them. Everyone is trying to navigate through this critical time.Join Dr. Donelda Gowan on the Massage Therapy Without Borders podcast to discuss the world of massage therapy after COVID-19 and the opportunities it presents.**********About Our GuestDr. Gowan is the Research Chair of the Board at MTAS and a highly qualified health professional offering her insight into how the profession can grow in the new landscape emerging from the effects of COVID-19.Support the showCheck out our new podcast! The Rub: a podcast about massage therapyGiving Tuesday is over, but you can still support Healwell and the cool things we make by donating here!Other ways to help and join in: Leave us a review on Apple Podcasts Let us know what you think! Send us an email: podcast@healwell.org Find bonus content from Interdisciplinary and early release episodes for our current show: "The Rub" on Patreon! Check Healwell's live and online classes Continue the conversation with a two-week free trial of the Healwell Community Merch! Find your Healwell fashion here Find a copy of Rebecca Sturgeon's book: "Oncology Massage: An Integrative Approach to Cancer Care" Thank you to ABMP for sponsoring Interdisciplinary!...

Link to bioRxiv paper: http://biorxiv.org/cgi/content/short/2023.04.25.538200v1?rss=1 Authors: Peng, Y., Zhang, Y., Fang, R., Jiang, H., Lan, G., Liu, Y., Nie, Z., Zhang, S.-D., Ma, Y., Yang, P., Wang, F., Ge, H.-H., Zhang, W.-D., Luo, C., Li, A., He, W. Abstract: Centromere protein A (CENP-A) is a centromere-specific protein that determines kinetochore positioning and the accuracy of chromosome segregation. Despite its recognized importance in maintaining mitotic fidelity, the molecular details of CENP-A regulation in mitosis are still obscure. We performed a structure-activity relationship (SAR) study of the cell cycle-arresting indole terpenoid mimic JP18 and identified two more potent analogues, (+)-6-Br-JP18 and (+)-6-Cl-JP18. Tubulin was identified as a potential protein target of these two halogenated analogues by using the drug affinity responsive target stability (DARTS) based method. X-ray crystallographic analysis determined that (+)-6-Br-JP18 and (+)-6-Cl-JP18 bind to the colchicine-binding site of beta-tubulin. We further found that treatment of cancer cells with microtubule-targeting agents (MTAs), including these two compounds, upregulated CENP-A by destabilizing Cdh1, an E3 ubiquitin ligase component. The mechanistic study revealed that Cdh1 mediates proteolysis of CENP-A in mitosis, specifying the role of Cdh1 in maintaining mitotic fidelity. Copy rights belong to original authors. Visit the link for more info Podcast created by Paper Player, LLC

Alice talks with the guys about the LIRR mess at Grand Central Station. Commuters are not impressed with the MTAs work.

Laura and Rebecca talk with Lori Green about how things are going in Saskatchewan, Canada. What does it mean to support the only unregulated health care profession in a province? How's it going with the drive for massage therapy regulation in Saskatchewan? And what can we learn from each other? ********** Let us know what you think! Send us an email: podcast@healwell.org *********** Support the podcast (and see the video of podcast episodes along with extra conversation) on Patreon: patreon.com/interdisciplinary ********** Continue the conversation with us in the Healwell Community: community.healwell.org ********** About Our Guest: Lori Green is entering into her 18th year as Executive director with MTAS. (https://www.saskmassagetherapy.com/) They have stepped into the beginning of regulation in the Province of Saskatchewan with the Massage Therapy Act. Currently work is being done in developing the administrative bylaws and policies. Lori Green is NOT a massage therapist; she believes passionately in the continuing pursuit of further evolution of massage therapy through education, research and knowledge transfer.

Meine GästinMeine Gästin dieser Folge ist die liebe Selina. Selina arbeitet als Medizinisch-Technische-Assistentin im Labor eines Krankenhauses. Selina berichtet davon, dass die Arbeit als MTA aus vielen Gründen sehr belastend ist: Fachkräfte- und Nachwuchskräftemangel, kritische Personalsituation, mangelnde Wertschätzung.Für die Pflegekräfte und Ärzt:innen wurde in Corona-Zeiten geklatscht, die Labore kamen mit den Testauswertungen nicht hinterher. Als wäre es nicht schon frech genug, die Labore in dieser Ausnahmesituation entgegen der anderen medizinischen Kräfte zu beschimpfen statt zu beklatschen, nein: Es fragt auch hier keiner nach dem "Warum". Dennoch eint sowohl die Pflegekräfte, Ärzt:innen und MTAs eins: So schnell wie die Not erkannt wird, ist sie auch wieder verdrängt. Der Dank der Politik war groß, passiert ist nach wie vor nichts.Es ist so herrlich zu beobachten, wenn einem nichts mehr bleibt als Galgenhumor: Das Schiff ist lange untergegangen, die Politiker:innen mitsamt dem wenig engagierten Teil der Gesellschaft steht samt der fröhlich trällernden Kapelle am Steg, während Spahn zu Lindner säuselt: "Ich nehm' noch 'n Sekt vielleicht?!". Es ist und bleibt peinlich. Zu mir und meiner ArbeitMeine Webseite - Hier findest du alle Informationen rund um die Podcast-Folge (Quellen, Empfehlungen etc.)Mein YouTube-KanalDu möchtest deine Geschichte teilen oder (ggf. auch anonym) auf Missstände hinweisen? Dann schreib mir!Instagram oder @hart_aber_vaziE-Mail: podcast@hart-aber-vazi.de Meine verschlüsselte E-Mail Adresse, um deine Anonymität zu schützen: zimmermann.vanessa@protonmail.com 

Welcome to Season 4 of the Able Voice Podcast! If you are new here... we're glad to have you join us for this journey of creating an archive of music therapy and creative professional stories. Through conversations with music therapists & allied professionals in Canada and around the world, we listen to unique stories and learn more about interesting projects and various passions for music therapy. Our initiative is to celebrate our unique journeys as music therapists and provide tangible resources and professional development opportunities for MTAs through this medium. Subscribe to the Able Voice Podcast, leave us a review and connect with us (@ablevoicepodcast or @synergymusictherapy) to share your experiences and takeaways. We release new episodes every other Sunday between the end of January and end of August. AVP Theme Music by: Christopher Mouchette. Follow him on Soundcloud (Chris Mouchette). Episode edited by: Justis Krar (@immvproductions) Rate and review the podcast on Apple Podcasts here: https://podcasts.apple.com/us/podcast/able-voice-podcast/id1505215850 -- The Able Voice Podcast is hosted by certified music therapists Hayley Francis Cann (@mtahayley) and Kimberly Dolan (@mta.kimberly). Get in touch with Hayley and/or Kim by emailing contactsynergymt@gmail.com or visit www.synergymusictherapy.com.

This podcast will change the way you think about pulpotomies and endodontics in general.  Georg Benjamin explains that severe throbbing pain (or classic signs of IRREVERSIBLE PULPITIS) does not necessarily mean a pulpectomy is needed. Instead, we can consider a pulpotomy for permanent teeth to preserve radicular pulp tissue and maintaining a vital tooth! Download Protrusive App on iOS and Android and Claim your Verifiable CPD/CE answering a few questions + EXCLUSIVE content: https://youtu.be/PoWDRz714uQ Check out this full episode on YouTube Protrusive Dental Pearl: Check if your anesthetic is successful by carrying out an objective test by placing EndoFrost (-50 C) on the tooth (about 10 secs) and checking for a cold response. If the patient is not fully numb yet, they will still feel something. If they are sufficiently numb, this test gives you (and some nervous patients!) confidence. I like this before placing rubber dam as I hate ever removing the dam to top up LA! Need to Read it? Check out the Full Episode Transcript below! Highlights of this episode: 2:02 Protrusive Dental Pearl4:47 Georg Benjamin's Dental Podcast Journey7:10 Georg's Endodontic Journey11:46 Case Discussion: Pulpal Diagnosis16:17 Pulpotomy19:37 Direct Pulp capping 22:26 Indirect Pulp Cap23:58 Pulpotomy Protocol26:59 Classifications of Pulpotomy 30:52 Bleeding Time Protocol33:31  Patient Communication 35:34 Treatment Decision-Making38:57 Success rate of pulpotomy41:10 Early and Late failures42:30 Long-term treatment45:14 Unhealthy pulp48:08 Materials and Products for Pulpotomy50:54 Leaving carious dentine as base For our German Protruserati, check out Georg's Dental Podcast If you enjoyed this, you might also like this episode with  Dr Ammar Al-Hourani 'Is Single Point Obturation Acceptable?' Click below for full episode transcript: Jaz's Introduction: Grab your onions Protruserati, because this podcast will change the way you think about a pulpectomy, you will probably do way LESS EXTIRPATIONS and committing to a root canal. Jaz's Introduction:And this episode really challenge our beliefs that we hold in terms of what requires a root canal treatment, ie we were trained that irreversible pulpitis equals pulpectomy, which is a root canal right? Now, that's what I was taught to. But what is happening now in endodontics, is brilliant. And Georg explains it really well, with his lovely German accent, we go over the fact that nowadays, whenever a patient comes to Georg, with irreversible pulpitis , that you know, severe throbbing ache, it does not mean root canal for him anymore, it means a PULPOTOMY OF THE PERMANENT TOOTH, it means a pulpotomy of a vital permanent tooth, which then hopefully, will preserve that radicular pulpal tissue, and therefore, the patient will not require a root canal treatment anymore. So, it's pretty different. Now, maybe you're already seasoned in this, maybe you've already using MTAs, and whatnot. And that's amazing. Good for you. But for a lot of dentists, I imagine this is like, wait, what do you what do you mean, we don't have to do I commit to a root canal anymore like we can, we can actually do a pulpotomy for an adult, let alone one that we have diagnosed as, quote unquote, 'irreversible pulpitis', which actually Georg argues, is a poor term. Welcome, Protruserati. I'm Jaz Gulati, I'm your host. And if you're new to the podcast, welcome. It's great to have you. If you're a veteran, and you've been with me for many years, it's always a pleasure to have you. This one's a really cool episode, I didn't think before I recorded it, that I'll be having so many moments of laughter with our guests, Georg Benjamin, who was not a specialist in Germany, he is pretty much limited to endodontics. And he's been following vital pulp therapy or pulpotomy of vital adult teeth for a long while now. And he's got some great views on it. And if you listen to the end,

The Undersecretary for Acquisition & Sustainment (USD A&S) Bill LaPlante joined us at the 2022 Conference hosted by George Mason University and Defense Acquisition University. He was on fire and dropped a ton of amazing insights, so I had to republish the audio to the podcast. I'll link to the video when it's up, but you'll get to listen to it here first. Bill LaPlante touches a number of important areas. The outline of the discussion is below. 2:30 - Production really matters 3:30 - Minimum sustaining rate 4:50 - HIMARS produced in a converted diaper factory 5:50 - In the past, DoD stopped production on HIMARS, Mark 48 torpedo, and Tomahawk 6:45 - In 70 years of demos, DoD has not gotten hypersonics into production 7:50 - DoD was bad at prototyping until MTAs and OTAs 8:30 - Don't tell me it's got AI and quantum, don't drop DevSecOps -- production at scale 9:20 - If something blew up in INDOPACOM next week, what does DoD have in quantity? 10:30 - Null Program found it takes 4 years for DoD to produce nothing 11:15 - Tech bros aren't helping much in Ukraine 12:45 - RFPs, source selections, money -- that's what matters 14:30 - FFRDCs get paid to write a paper that finds when quantity goes down, price goes up (duh!) 15:00 - Predicts that Congress will put billions into production lines 15:30 - M777, HIMARS, Stinger all have obsolescence issues 17:30 - National Armaments Directors from 45 partner countries meet to coordinate 18:30 - Industry won't invest without demand signal because DoD left them "holding the bag" in the past 18:45 - Supply chain issues in microelectronics, solid rocket motors, actuators, rare earth magnets 19:15 - Allies must not only be interoperable, but interchangeable 20:00 - Industry must be forced into interchangeability, like MOSA, because it lowers barriers to entry 20:30 - Take advantage of allied non-recurring development, like on E-7 Wedgetail 21:30 - US weapon production lines opening in Japan and Australia is a key deterrent 22:45 - Outsourcing production was a bad idea, dev & prod must be co-located 23:45 - Japan strategically kept rare earth processing capacity 26:00 - In JADC2, latency matters, link budgets matter 27:40 - Services working together very well on JADC2 28:30 - JTRS architecture was flawed from first principles, no one caught it 29:00 - Service oriented architecture was wrong for things like GPS OCX 32:30 - $50B spent on MTA, $2B for SWP (and another $8B in POM) 33:15 - MTA, SWP, BA 8 are small slivers compared to traditional acquisition 34:15 - Cycle time from Milestone B to C has not increased since 1960s, still 5-7 years 35:40 - Definition of success: production, relevant in high-end fight, and DOTMLPF 36:15 - Derek Tournear and SDA on path to do something remarkable 36:45 - Conventional Prompt Strike MTA may be first hypersonic in production next year 37:00 - Not many MTA successes in production yet 37:30 - OTAs not good for large weapon systems where DoD needs data rights 40:30 - Requirements, PPBE, and acquisition report up different chains, not synced 40:00 - How Air Force RCO decisions are made at the top, quickly 41:30 - RCO model doesn't scale to entire DoD, senior lead attention limited 42:20 - PEOs must be able to trade requirements and money in year of execution 42:30 - Cool if PPBE commission could make PPBE agile 44:15 - Appropriators won't want to give DoD flexibility 44:30 - Without PPBE reform, DoD is doing a "Poor Man's" version of portfolio management 46:25 - Remembering the late Ash Carter 47:00 - Acquisition community was not at war until 2009 47:30 - Creation of the Senior Integration Group (SIG) 51:30 - Bipartisan support for national security 52:40 - DoD response to inflation 53:00 - Believes suppliers are hurt by inflation, but no data yet 55:30 - Expects CPIF contracts will slip due to inflation 57:30 - Competition changes behavior, no question 57:50 - Little difference between classified info on Ukraine and public news 58:40 - Acquisition is fun

How to learn guitar. Breaking through into the heavenlies with the sound of gratitude. "When Harry Met Sally" quotes. The tension of presentation and posture during worship. This episode covers it all. Let's join Brandon Lake in expressing gratitude to the Lord for what He has done. Engage the rest of the MTAS community by going to our website. https://morethanasongpodcast.podbean.com/

Doknow calls Adam for reinforcements, to chop it up with the graffiti team MTA Crew. ----- 00:00 Intro 1:26 - Being the first graffiti crew to have a g*ng injunction 3:07 - MTA crew brings Adam a gift 6:49 - Gaso on what being in MTA was like in his teen years and stealing a lot of paint before becoming financially able to afford it 13:52 - Graffiti writers and dr*gs, most writers being degenerates 15:18 - Being lifers in the graffiti game, not getting money or anything from it 16:03 - Not hating on people commercializing or trying to monetize graffiti, No Mas doing 10 years in the feds 24:40 - Getting tipped off about a possible raid on MTAs before it happened 28:25 - No Mas on going to prison for graffiti, becoming better, and learning from it 30:24 - Sufer on going to Europe to spray paint and getting arrested in Paris last week 32:45 - Gaso remembers getting electrocuted while trying to get on top of a building in downtown LA, Sufer talks about getting sh*t at while out tagging 46:08 - Sufer speaks on Selling the MTA chain after paying 32k for it 48:00 - Sufer and Gaso disagree on whether or not it's okay to spray paint on a church 53:06 - Advice to a new graffiti artist, if you're afraid of jail don't do it, 56:11 - #1 Rule of spraying, daylight spraying ----- NO JUMPER PATREON http://www.patreon.com/nojumper CHECK OUT OUR NEW SPOTIFY PLAYLIST https://open.spotify.com/playlist/5te... FOLLOW US ON SNAPCHAT FOR THE LATEST NEWS & UPDATES https://www.snapchat.com/discover/No_... CHECK OUT OUR ONLINE STORE!!! http://www.nojumper.com/ SUBSCRIBE for new interviews (and more) weekly: http://bit.ly/nastymondayz  Follow us on SPOTIFY: https://open.spotify.com/show/4ENxb4B... iTunes: https://itunes.apple.com/us/podcast/n... Follow us on Social Media: https://www.snapchat.com/discover/No_... http://www.twitter.com/nojumper http://www.instagram.com/nojumper https://www.facebook.com/NOJUMPEROFFI... http://www.reddit.com/r/nojumper JOIN THE DISCORD: https://discord.gg/Q3XPfBm Follow Adam22: https://www.tiktok.com/@adam22 http://www.twitter.com/adam22 http://www.instagram.com/adam22 adam22hoe on Snapchat Learn more about your ad choices. Visit megaphone.fm/adchoices

Mtas risadas e risadas e risadas e risad.... ENFIM! Unico podcast que irá falar bem do filme do Thor e da Thora! ELENCO: Carlos: carlos_augusto_quo Sérgio: sergio.oaugusto REDES SOCIAIS: Facebook: Corporação Cast Instagram: corporacaocast Twitter: corporacaocast RECOMENDAÇÕES DA SEMANA: Vc é msm tão melhor que eu? - Ananda (música) BZRP Music Sessions #52 - QUEVEDO (música) The Dying Song - Slipknot (música) Sugestões, cartas, dicas, TEMAS ou patrocinios!?!?! Mande no nosso email: corporacaocast@gmail.com E se quiser trocar uma ideia na humildade e disciplina, chame no direct! Tanto do podcast quanto dos nossos pessoais E essa foi mais uma épica aventura do Corporação Cast! --- This episode is sponsored by · Anchor: The easiest way to make a podcast. https://anchor.fm/app Support this podcast: https://anchor.fm/corporau00e7u00e3o-cast/support

In today's show, we welcome Amanda Schenstead from Regina Saskatchewan. Listen in as Amanda speaks about her journey as a music therapist and her role as President of the Music Therapy Association of Saskatchewan. She also tells us more about how she views music therapy as a part of overall wellness. A little more about Amanda: Amanda Schenstead grew up in small town Whitewood, SK and after graduating from high school, she attended Brandon University where she completed a Bachelor Degree in Music with Majors in Flute Performance and Minors in Theatre and English. She then went on to complete a Master of Music Therapy Degree at Wilfrid Laurier University in Waterloo, ON where she was also a recipient of a SSHRC Scholarship for her arts-based major research project. In 2009, she returned home to Saskatchewan where she has since been working as a music therapist at Wascana Rehabilitation Centre with the Veterans and Extended Care programs. She has also enjoyed work in the Palliative Care program which operates out of the Pasqua Hospital. Outside of work, Amanda is an active member of Regina's theatre community as an actor, director, musician, and playwright. She also enjoys weekly games of Dungeons & Dragons. MTAS website: https://musictherapysk.com/ MTAS Facebook: https://www.facebook.com/Music-Therapy-Association-of-Saskatchewan-272929639392252/ To join the discussion online, please use hashtag #CanadianMusicTherapy

With over 2.6 billion active users ad 4.6billion active accounts email has become a significant means of communication in the business, professional, academic, and personal worlds. Before email we had protocols that enabled us to send messages within small splinters of networks. Time Sharing systems like PLATO at the University of Champaign-Urbana, DTSS at Dartmouth College, BerkNet at the University of California Berkeley, and CTTS at MIT pioneered electronic communication. Private corporations like IBM launched VNET We could create files or send messages that were immediately transferred to other people. The universities that were experimenting with these messaging systems even used some of the words we use today. MIT's CTSS used the MAIL program to send messages. Glenda Schroeder from there documented that messages would be placed into a MAIL BOX in 1965. She had already been instrumental in implementing the MULTICS shell that would later evolve into the Unix shell. Users dialed into the IBM 7094 mainframe and communicated within that walled garden with other users of the system. That was made possible after Tom Van Vleck and Noel Morris picked up her documentation and turned it into reality, writing the program in MAD or the Michigan Algorithm Decoder. But each system was different and mail didn't flow between them. One issue was headers. These are the parts of a message that show what time the message was sent, who sent the message, a subject line, etc. Every team had different formats and requirements. The first attempt to formalize headers was made in RFC 561 by Abhay Bhutan and Ken Pogran from MIT, Jim White at Stanford, and Ray Tomlinson. Tomlinson was a programmer at Bolt Beranek and Newman. He defined the basic structure we use for email while working on a government-funded project at ARPANET (Advanced Research Projects Agency Network) in 1971. While there, he wrote a tool called CYPNET to send various objects over a network, then ported that into the SNDMSG program used to send messages between users of their TENEX system so people could send messages to other computers. The structure he chose was Username@Computername because it just made sense to send a message to a user on the computer that user was at. We still use that structure today, although the hostname transitioned to a fully qualified domain name a bit later. Given that he wanted to route messages between multiple computers, he had a keen interest in making sure other computers could interpret messages once received. The concept of instantaneous communication between computer scientists led to huge productivity gains and new, innovative ideas. People could reach out to others they had never met and get quick responses. No more walking to the other side of a college campus. Some even communicated primarily through the computers, taking terminals with them when they went on the road. Email was really the first killer app on the networks that would some day become the Internet. People quickly embraced this new technology. By 1975 almost 75% of the ARPANET traffic was electronic mails, which provided the idea to send these electronic mails to users on other computers and networks. Most universities that were getting mail only had one or two computers connected to ARPANET. Terminals were spread around campuses and even smaller microcomputers in places. This was before the DNS (Domain Name Service), so the name of the computer was still just a hostname from the hosts file and users needed to know which computer and what the correct username was to send mail to one another. Elizabeth “Jake” Feinler had been maintaining a hosts file to keep track of computers on the growing network when her employer Stanford was just starting the NIC, or Network Information Center. Once the Internet was formed that NIC would be the foundation or the InterNIC who managed the buying and selling of domain names once Paul Mockapetris formalized DNS in 1983. At this point, the number of computers was increasing and not all accepted mail on behalf of an organization. The Internet Service Providers (ISPs) began to connect people across the world to the Internet during the 1980s and for many people, electronic mail was the first practical application they used on the internet. This was made easier by the fact that the research community had already struggled with email standards and in 1981 had defined how servers sent mail to one another using the Simple Mail Transfer Protocol, or SMTP, in RFC 788, updated in 1982 with 821 and 822. Still, the computers at networks like CSNET received email and users dialed into those computers to read the email they stored. Remembering the name of the computer to send mail to was still difficult. By 1986 we also got the concept routing mail in RFC 974 from Craig Partridge. Here we got the first MX record. Those are DNS records that define the computer that received mail for a given domain name. So stanford.edu had a single computer that accepted mail for the university. These became known as mail servers. As the use of mail grew and reliance on mail increased, some had multiple mail servers for fault tolerance, for different departments, or to split the load between servers. We also saw some split various messaging roles up. A mail transfer agent, or MTA, sent mail between different servers. The received field in the header is stamped with the time the server acting as the MTA got an email. MTAs mostly used port 25 to transfer mail until SSL was introduced when port 587 started to be used for encrypted connections. Bandwidth and time on these computers was expensive. There was a cost to make a phone call to dial into a mail provider and providers often charged by the minute. So people also wanted to store their mail offline and then dial in to send messages and receive messages. Close enough to instant communication. So software was created to manage email storage, which we call a mail client or more formally a Mail User Agent, or MUA. This would be programs like Microsoft Outlook and Apple Mail today or even a web mail client as with Gmail. POP, or Post Office Protocol was written to facilitate that transaction in 1984. Receive mail over POP and send over SMTP. POP evolved over the years with POPv3 coming along in 1993. At this point we just needed a username and the domain name to send someone a message. But the number of messages was exploding. As were the needs. Let's say a user needed to get their email on two different computers. POP mail needed to know to leave a copy of messages on servers. But then those messages all showed up as new on the next computer. So Mark Crispin developed IMAP, or Internet Message Access Protocol, in 1986, which left messages on the server and by IMAPv4 in the 1990s, was updated to the IMAPv4 we use today. Now mail clients had a few different options to use when accessing mail. Those previous RFCs focused on mail itself and the community could use tools like FTP to get files. But over time we also wanted to add attachments to emails so MIME, or Multipurpose Internet Mail Extensions became a standard with RFC 1341 in 1993. Those mail and RFC standards would evolve over the years to add better support for encapsulations and internationalization. With the more widespread use of electronic mail, the words were shortened and to email and became common in everyday conversations. With the necessary standards, the next few years saw a number of private vendors jump on the internet bandwagon and invest in providing mail to customers America Online added email in 1993, Echomail came along in 1994, Hotmail added advertisements to messages, launching in 1996, and Yahoo added mail in 1997. All of the portals added mail within a few years. The age of email kicked into high gear in the late 1990s, reaching 55 million users in 1997 and 400 million by 1999. During this time having an email address went from a luxury or curiosity to a societal and business expectation, like having a phone might be today. We also started to rely on digital contacts and calendars, and companies like HP released Personal Information Managers, or PIMs. Some companies wanted to sync those the same way they did email, so Microsoft Exchange was launched in 1996. That original concept went all the way back to PLATO in the 1960s with Dave Wooley's PLATO NOTES and was Ray Ozzie's inspiration when he wrote the commercial product that became Lotus Notes in 1989. Microsoft inspired Google who in turn inspired Microsoft to take Exchange to the cloud with Outlook.com. It hadn't taken long after the concept of sending mail between computers was possible that we got spam. Then spam blockers and other technology to allow us to stay productive despite the thousands of messages from vendors desperately trying to sell us their goods through drip campaigns. We've even had legislation to limit the amount of spam, given that at one point over 9 out of 10 emails was spam. Diligent efforts have driven that number down to just shy of a third at this point. Email is now well over 40 years old and pretty much ubiquitous around the world. We've had other tools for instant messaging, messaging within every popular app, and group messaging products like bulletin boards online and now group instant messaging products like Slack and Microsoft Teams. We even have various forms of communication options integrated with one another. Like the ability to initiate a video call within Slack or Teams. Or the ability to toggle the Teams option when we send an invitation for a meeting in Outlook. Every few years there's a new communication medium that some think will replace email. And yet email is as critical to our workflows today as it ever was.

Please join Troutman Pepper's Intellectual Property and Health Sciences practice groups for the fifth installment of their podcast series on strategy, trends, and other happenings at the PTAB. Moderated by Troutman Pepper Partner Maia Harris, this episode features Troutman Pepper Partners Michael Goldman, Edwin (Ted) Merkel, and Andrew Zappia, who focus on the PTO's recent announcement to extend its Motion to Amend (MTA) Pilot Program. Our speakers discuss MTAs generally, pilot program details, as well as strategies and further considerations on seeking amendments during IPR as opposed to other available post-grant options. Be on the lookout for our next episode of this podcast series, where we will discuss arguments on secondary considerations during IPRs.

This episode is a little different! We have two guests joining us, Mary Meads and Tess McKinnon. Mary is a licence owner for the evidence-based, Canadian program called Sing it Girls and Tess has been a participant of the Sing it Girls program at 4 different times over the past year. They talk about their experiences both facilitating the program and from a participant's perspective. A little more about Tess McKinnon: Tess is 11 years old and lives in Waterloo Ontario with her family and 2 guinea pigs, Sherlock & Watson. She loves performing, including dance, drama and singing. Her favorite subject is science, and she likes to play badminton. When she's bored, she likes to read, hangout with her friends, do crafts, and play with her guinea pigs. A little more about Mary Meads: Mary Meads (she/her) is a Credentialed Music Therapist and owner of Wellington Music Therapy Services. A graduate of the Concordia Creative Arts Therapies Masters, Music Therapy option, Mary returned home to Guelph, Ontario to set up her practice with hopes of extending the powerful reaches of music therapy deep into Guelph and the surrounding areas. She loves connecting with community partners and families, developing new programs, advocating for the profession, and engaging with her team of 8 MTAs to offer high quality and exciting music therapy & Community music programs. Mary's current clinical work focuses on Older Adults Living in Long-Term Care settings, early intervention / early childhood music education, and using the singing voice to enhance wellbeing. Mary also holds a part time position at St. Joseph's Health Care Centre in Guelph, where she supports those living in Long Term Care. Next steps for Mary include engaging more deeply in Anti Oppressive Practice, and leaning into a broader application of music and health on a community level. To join the discussion online, please use hashtag #CanadianMusicTherapy Learn more about buying a Sing it Girls licence here: www.singitgirls.ca

Building a large, stateful Kafka Streams application that tracks the state of each outgoing email is crucial to marketing automation tools like Mailshimp. Joining us today in this episode, Mitch Seymour, staff engineer at Mailchimp, shares how ksqlDB and Kafka Streams handle the company's largest source of streaming data.  Almost like a post office, except instead of sending physical parcels, Mailchimp sends billions of emails per day. Monitoring the state of each email can provide visibility into the core business function, and it also returns information about the health of both internal and remote message transfer agents (MTAs). Finding a way to track those MTA systems in real time is pivotal to the success of the business. Mailchimp is an early Apache Kafka® adopter that started using the technology in 2014, a time before ksqlDB, Kafka Connect, and Kafka Streams came into the picture. The stream processing applications that they were building faced many complexities and rough edges. As their use case evolved and scaled overtime at Mailchimp, a large number of applications deviated from the initial implementation and design so that different applications emerged that they had to maintain. To reduce cost, complexity, and standardize stream processing applications, adopting ksqlDB and Kafka Streams became the solution to their problems. This is what Mitch calls, “minimizing software speciation in our software” It's the idea when applications evolved into multiple systems to respond to failure-handling strategies, increased load, and the like. Using different scaling strategies and communication protocols creates system silos and can be challenging to maintain.Replacing the existing architecture that supported point-to-point communication, the new Mailchimp architecture uses Kafka as its foundation with scalable custom functions, such as a reusable and highly functional user-defined function (UDF). The reporting capabilities have also evolved from Kafka Streams' interactive queries into enhanced queries with Elasticsearch. Turning experiences into books, Mitch is also an author of O'Reilly's Mastering Kafka Streams and ksqlDB and the author and illustrator of Gently Down the Stream: A Gentle Introduction to Apache Kafka. EPISODE LINKSThe Exciting Frontier of Custom ksql Functions (Mitch Seymour, Mailchimp) Kafka Summit LondonApache Kafka 101: Kafka Streams CourseksqlDB UDFs and UDADs Made EasyUsing Apache Kafka as a Scalable, Event-Driven Backbone for Service ArchitecturesThe Haiku Approach to Writing SoftwareWatch the video version of this podcastJoin the Confluent CommunityLearn more with Kafka tutorials, resources, and guides at Confluent DeveloperLive demo: Kafka streaming in 10 minutes on Confluent CloudUse PODCAST100 to get an additional $100 of free Confluent Cloud usage (details)

E hoje a gente bate aquele papinho rapidinho sobre esse novo HE-MAN que a nossa linda @netflix está prometendo pra gente, o que a gente lembra e o que será que teremos nessa obra ressuscitada ein ?? Mtas curiosidades hj nesses nossos 15 minutinhos sem Pauta do PPPOD. Bora ouvir !! E Segue a gente lá no INSTAGRAM no @pedrapapelepodcast !! Pela Honra de Grayskull --- Send in a voice message: https://anchor.fm/pedrapapelepodcast/message

Metropolitan Transportation Authority Threatens Massive Job & Service Cuts The Metropolitan Transpiration Authoritys Dooms Day Budget threatens to cut more than 9000 jobs and 40% of the train and bus services for riders. Joining us to talk about the MTAs pandemic panic is John Samuelsen International President of the 150,000 worker strong Transport Workers Union The MTA says get back, Samuelsen's union will Fight Back!

Link to bioRxiv paper: http://biorxiv.org/cgi/content/short/2020.10.19.345975v1?rss=1 Authors: Banik, A., Ahmed, S. R., Sajib, E. H., Deb, A., Sinha, S., Azim, K. F. Abstract: The deeper understanding of metastasis phenomenon and detection of drug targets could be a potential approach to minimize cancer mortality. In this study, attempts were taken to unmask novel therapeutics to prevent metastasis and cancer progression. Initially, we explored the physiochemical, structural and functional insights of three metastasis tumor antigens (MTAs) and evaluated some plant based bioactive compounds as potent MTA inhibitors. From 50 plant metabolites screened, isoflavone, gingerol, citronellal and asiatic acid showed maximum binding affinity with all three MTA proteins. The ADME analysis detected no undesirable toxicity that could reduce the drug likeness properties of top plant metabolites. Moreover, molecular dynamics studies revealed that the complexes were stable and showed minimum fluctuation at molecular level. We further performed ligand based virtual screening to identify similar drug molecules using a large collection of 3,76,342 compounds from DrugBank. The results suggested that several structural analogs (e.g. Tramadol, Nabumetone, DGLA, Hydrocortisone) may act as agonist to block the MTA proteins and inhibit cancer progression at early stage. The study could be useful to develop effective medications against cancer metastasis in future. Due to encouraging results, we highly recommend further in vitro and in vivo trials for the experimental validation of the findings. Copy rights belong to original authors. Visit the link for more info

Volume 11, Issue 25 of @Oncotarget reported that to examine the role of RSK in AML, the authors analyzed apoptosis and the cell cycle profile following treatment with BI-D1870, a potent inhibitor of RSK. BI-D1870 treatment increased the G2/M population and induced apoptosis in Acute Myeloid Leukemia cell lines and patient Acute Myeloid Leukemia cells. Therefore, the authors investigated whether BI-D1870 potentiates the anti-leukemic activity of vincristine by targeting mitotic exit. Combination treatment of BI-D1870 and vincristine synergistically increased mitotic arrest and apoptosis in acute leukemia cells. These data show that BI-D1870 induces apoptosis of AML cells alone and in combination with vincristine through blocking mitotic exit, providing a novel approach to overcoming vincristine resistance in AML cells. Dr. Kathleen M. Sakamoto from Stanford University School of Medicine said, "Acute myeloid leukemia (AML) is a genetically and phenotypically heterogeneous hematologic malignancy characterized by the accumulation of immature myeloid blasts with resultant peripheral blood cytopenia." Treatment of cells with microtubule targeting agents, including paclitaxel and the vinca alkaloid vincristine, blocks the proper formation of the mitotic spindle through inhibition of microtubule dynamics, resulting in the prolonged mitotic arrest of cancer cells. MTAs-treated mitotic arrested cells may undergo apoptosis in mitosis, however, the rapid degradation of Cyclin B due to an insufficient SAC leads to the mitotic slippage into tetraploid G1 stage in resistant cells. Though vinca alkaloid microtubule-destabilizing compounds have shown clinical efficacy against various hematological malignancies and were included in combination chemotherapy of the VAPA study, they are not currently used in induction chemotherapy for AML due to their high toxicity against lymphoid cells and rapid degradation by myeloperoxidase in AML cells. In this study, they demonstrate that BI-D1870, a potent inhibitor of RSK, induces mitotic arrest, and apoptosis in AML cells without inhibiting CDC2 and CDC25C. Furthermore, BI-D1870 synergizes with vinca alkaloid vincristine in AML cells, suggesting that inhibition of mitotic exit with BI-D1870 could be a promising novel approach for AML therapy in combination with MTAs. The Sakamoto Research Team concluded in their Oncotarget Research Paper that BI-D1870 is a reversible pan-RSK inhibitor, showing > 500-fold higher activity for RSK than other AGC kinases. BI-D1870 also inhibits the activity of PLK1, Aurora-B, MELK, PIM3, MST2, and GSK3β at higher concentrations than for RSK. BI-D1870 and BRD7389 have been reported to inhibit proliferation and significantly increase the G2/M population in melanoma cells. BI-D1870 does not have proper physicochemical properties for clinical application. Future structure-activity relationships study for BI-D1870 is required to improve solubility and pharmacokinetic profiles for in vivo preclinical and clinical studies. Sign up for free Altmetric alerts about this article DOI - https://doi.org/10.18632/oncotarget.27630 Full text - https://www.oncotarget.com/article/27630/text/ Correspondence to - Kathleen M. Sakamoto - kmsakamo@stanford.edu Keywords - acute myeloid leukemia, BI-D1870, RSK, vincristine, spindle assembly checkpoint About Oncotarget Oncotarget is a weekly, peer-reviewed, open access biomedical journal covering research on all aspects of oncology. To learn more about Oncotarget, please visit https://www.oncotarget.com or connect with: Facebook - https://www.facebook.com/Oncotarget/ Twitter - https://twitter.com/oncotarget LinkedIn - https://www.linkedin.com/company/oncotarget Pinterest - https://www.pinterest.com/oncotarget/ Reddit - https://www.reddit.com/user/Oncotarget/ Oncotarget is published by Impact Journals, LLC please visit http://www.ImpactJournals.com or connect with @ImpactJrnls Media Contact MEDIA@IMPACTJOURNALS.COM 18009220957x105

What comes to mind when you think about New York City? Is it the pizza? Your daily chopped cheese and Arizona can? Or is it one of the most culturally iconic forms of transportation that has been apart of the history of NYC for almost 150 years? That's right people, we're talking about trains. More specifically the MTA: from its inception and glory days to its current downfall. What’s wrong with the MTA and how to fix it?What are the MTAs biggest challenges?Failures of the MTAHistory of the inception of the MTA If you can, check out this link to support our show!Disclaimer: The views, information, or opinions expressed here on Pod for the Planet are solely those of the individuals involved and do not necessarily represent the official policy or position of any other agency, organization, employer or company.Twitter: @pod4theplanet Instagram: @pod4theplanet Music By Matt Cincinnati

The Massage Therapy Association of Saskatchewan Executive Director, Lori Green, joins me this episode to discuss being an Executive Director, where things are at in Saskatchewan, and her thoughts on a what's happening nationally in Registered Massage Therapy. Site links are Canadian Massage Therapy Alliance http://www.crmta.ca/ RMT Act https://www.rmtact.ca/ Massage Therapy Association of Saskatchewan https://www.saskmassagetherapy.com/   Music by Nite Owl Broke for Free

You Don't Even Go Here.

Pod pod pod pod pod to the top.

Den 14 oktober år 1930 går president Kaarlo Juho Ståhlberg på sin vanliga morgonpromenad tillsammans med sin fru Ester på Brändö i Helsingfors. På vägen möter de en mörkgrön Chevrolet, och två män som stiger ur bilen. Männen lyfter in presidenten i bilen, varmed fru Ester sätter sig i baksätet och meddelar att hon tänker åka med. Nu börjar en 700 kilometer lång bilresa genom Finland under pistolhot. Svenska Yles krimpodd i tre delar berättar om händelserna år 1930, året då Finland var nära en statskupp och diktatur. Under sommaren, mellan maj och oktober, utförde högerradikala aktivister över 250 kidnappningar, skjutsningen av presidentparet var den sista. Manus och regi: Mikaela Weurlander Ljuddesign: Jyrki Häyrinen Dramaturgi: Mikaela Weurlander, Are Nikkinen, Staffan von Martens

Every ride has bumps, I choose to keep driving.

Email deliverability rates are impacted by following standard best practices. But adhering to such best practices and industry standards is often not enough. What is email deliverability? Deliverability is “a way to measure the success at which an email marketer gets a campaign into subscribers' inboxes. It involves every facet of email delivery: from the technical stuff like ISPs, MTAs, and throttling, to the aspects that you (and your client) can control, like the cleanliness of a list or an email's content.” – MailChimp “Simply put, successful email deliverability is your message arriving in the inbox of the recipient as intended. Email deliverability failure is when your message is either routed to the junk/bulk folder or blocked by an ISP (Internet Service Provider).” – SendGrid Your email needs to land in the inbox. Your marketing team needs the recipients to engage with those emails. Business owners expect emails to convert to subscribers and ultimately into sales. Did you know…. A lack of email engagement can lead to a decrease in your email deliverability rate? Now is the time to determine: What factors determine and influence the deliverability rate of an email used for marketing. What are the best practices to increase an email deliverability When marketers evaluate their email results, they look at engagement metrics based upon how the recipient engaged with or did not engage with the email they received. However, emails face the Goliath of companies that evaluate such metrics also. Such companies are called email service providers (ESP). These companies include Gmail, Yahoo, Microsoft, etc. Corporate email servers also have the dreaded IT guy who does not like you either. Email service providers view your email recipient as their customer, not yours. Marketers must pay attention to email deliverability factors and metrics. The positive and negative interactions with email subscribers determine where your incoming email is placed. Viral Solutions recently attended an event sponsored by ReturnPath. ReturnPath conducted a study using global consumer data consisting of over 17,000 commercial senders, 2 million consumer panelists, and over 5.5 billion commercial email messages sent to Microsoft, Gmail, Yahoo, and AOL users between January 1, 2017, and December 31, 2017. ReturnPath has distributed a free report about the hidden metric of email deliverability, and the following article is our notes for our readers. If you would like your own copy, please go to this link at ReturnPath.com. What metrics do email service providers look at?

This week on the show, we will be talking to FreeBSD developer and former core-team member John Baldwin about a variety of topics, including running a DevSummit, everything you needed or wanted to know. Coming up right now on BSDNow, the place to B...SD. This episode was brought to you by Headlines FreeBSD server retired after almost 19 years (http://www.theregister.co.uk/2016/01/14/server_retired_after_18_years_and_ten_months_beat_that_readers/) We've heard stories about this kind of thing before, that box that often sits under-appreciated, but refuses to die. Well the UK register has picked up on a story of a FreeBSD server finally being retired after almost 19 years of dedicated service. “In its day, it was a reasonable machine - 200MHz Pentium, 32MB RAM, 4GB SCSI-2 drive,” Ross writes. “And up until recently, it was doing its job fine.” Of late, however the “hard drive finally started throwing errors, it was time to retire it before it gave up the ghost!” The drive's a Seagate, for those of you looking to avoid drives that can't deliver more than 19 years of error-free operations. This system in particular had been running FreeBSD 2.2.1 over the years. Why not upgrade you ask? Ross has an answer for that: “It was heavily firewalled and only very specific services were visible to anyone, and most only visible to our directly connected customers,” Ross told Vulture South. “By the time it was probably due for a review, things had moved so far that all the original code was so tightly bound to the operating system itself, that later versions of the OS would have (and ultimately, did) require substantial rework. While it was running and not showing any signs of stress, it was simply expedient to leave sleeping dogs lie.” All in all, an amazing story of the longevity of a system and its operating system. Do you have a server with a similar or even greater uptime? Let us know so we can try and top this story. *** Roundup of all the BSDs (https://www.linuxvoice.com/group-test-bsd-distros/) The magazine LinuxVoice recently did a group test of a variety of “BSD Distros”. Included in their review were Free/Open/Net/Dragon/Ghost/PC It starts with a pretty good overview of BSD in general, its starts and the various projects / forks that spawned from it, such as FreeNAS / Junos / Playstation / PFSense / etc The review starts with a look at OpenBSD, and the consensus reached is that it is good, but does require a bit more manual work to run as a desktop. (Most of the review focuses on desktop usage). It ends up with a solid ⅘ stars though. Next it moves into GhostBSD, discusses it being a “Live” distro, which can optionally be installed to disk. It loses a few points for lacking a graphical package management utility, and some bugs during the installation, but still earns a respectable ⅗ stars. Dragonfly gets the next spin and gets praise for its very-up to date video driver support and availability of the HAMMER filesystem. It also lands at ⅗ stars, partly due to the reviewer having to use the command-line for management. (Notice a trend here?) NetBSD is up next, and gets special mention for being one of the only “distros” that doesn't do frequent releases. However that doesn't mean you can't have updated packages, since the review mentions pkgsrc and pkg as both available to customize your desktop. The reviewer was slightly haunted by having to edit files in /etc by hand to do wireless, but still gives NetBSD a ⅗ overall. Last up are FreeBSD and PC-BSD, which get a different sort of head-to-head review. FreeBSD goes first, with mention that the text-install is fairly straight-forward and most configuration will require being done by hand. However the reviewer must be getting use to the command-line at this point, because he mentions: “This might sound cumbersome, but is actually pretty straightforward and at the end produces a finely tuned aerodynamic system that does exactly what you want it to do and nothing else.” He does mention that FreeBSD is the ultimate DIY system, even to the point of not having the package management tools provided out of box. PC-BSD ultimately gets a lot of love in this review, again with it being focused on desktop usage this follows. Particularly popular are all the various tools written to make PC-BSD easier to use, such as Life-Preserver, Warden, the graphical installer and more. (slight mistake though, Life-Preserver does not use rsync to backup to FreeNAS, it does ZFS replication) In the end he rates FreeBSD ⅘ and PC-BSD a whopping 5/5 for this roundup. While reviews may be subjective to the particular use-case being evaluated for, it is still nice to see BSD getting some press and more interest from the Linux community in general. *** OpenBSD Laptops (http://www.tedunangst.com/flak/post/openbsd-laptops) Our buddy Ted Unangst has posted a nice “planning ahead” guide for those thinking of new laptops for 2016 and the upcoming OpenBSD 5.9 He starts by giving us a status update on several of the key driver components that will be in 5.9 release“5.9 will be the first release to support the graphics on Broadwell CPUs. This is anything that looks like i5-5xxx. There are a few minor quirks, but generally it works well. There's no support for the new Skylake models, however. They'll probably work with the VESA driver but minus suspend/resume/acceleration (just as 5.8 did with Broadwell).” He then goes on to mention that the IWM driver works well with most of the revisions (7260, 7265, and 3160) that ship with broadwell based laptops, however the newer skylake series ships with the 8260, which is NOT yet supported. He then goes on to list some of the more common makes and models to look for, starting with the broadwell based X1 carbons which work really well (Kris gives +++), but make sure its not the newer skylake model just yet. The macbook gets a mention, but probably should be avoided due to broadcom wifi The Dell XPS he mentions as a good choice for a powerful (portable) desktops *** Significant changes from NetBSD 7.0 to 8.0 (https://www.netbsd.org/changes/changes-8.0.html) Updated to GCC 4.8.5 Imported dhcpcd and replaced rtsol and rtsold gpt(8) utility gained the ability to resize partitions and disks, as well as change the type of a partition OpenSSH 7.1 and OpenSSL 1.0.1q FTP client got support for SNI for https Imported dtrace from FreeBSD Add syscall support Add lockstat support *** Interview - John Baldwin - jhb@freebsd.org (mailto:jhb@freebsd.org) / @BSDHokie (https://twitter.com/BSDHokie) FreeBSD Kernel Debugging News Roundup Dragonfly Mail Agent spreads to FreeBSD and NetBSD (https://www.dragonflydigest.com/2016/01/18/17508.html) DMA, the Dragonfly Mail Agent is now available not only in Dragonfly's dports, but also FreeBSD ports, and NetBSD pkgsrc “dma is a small Mail Transport Agent (MTA), designed for home and office use. It accepts mails from locally installed Mail User Agents (MUA) and delivers the mails either locally or to a remote destination. Remote delivery includes several features like TLS/SSL support and SMTP authentication. dma is not intended as a replacement for real, big MTAs like sendmail(8) or postfix(1). Consequently, dma does not listen on port 25 for incoming connections.” There was a project looking at importing DMA into the FreeBSD base system to replace sendmail, I wonder of the port signals that some of the blockers have been fixed *** ZFS UEFI Support has landed! (https://svnweb.freebsd.org/base?view=revision&revision=294068) Originally started by Eric McCorkle Picked up by Steven Hartland Including modularizing the existing UFS boot code, and adding ZFS boot code General improvements to the EFI loader including using more of libstand instead of containing its own implementations of many common functions Thanks to work by Toomas Soome, there is now a Beastie Menu as part of the EFI loader, similar to the regular loader As soon as this was committed, I added a few lines to it to connect the ZFS BE Menu to it, thanks to all of the above, without whom my work wouldn't be usable It should be relatively easy to hook my GELI boot stuff in as a module, and possibly just stack the UFS and ZFS modules on top of it I might try to redesign the non-EFI boot code to use a similar design instead of what I have now *** How three BSD OSes compare to ten Linux Distros (http://www.phoronix.com/scan.php?page=article&item=3bsd-10linux) After benchmarking 10 of the latest Linux distros, Phoronix took to benchmarking 3 of the big BSDs DragonFlyBSD 4.4.1 - The latest DragonFly release with GCC 5.2.1 and the HAMMER file-system. OpenBSD 5.8 - OpenBSD 5.8 with GCC 4.2.1 as the default compiler and FFS file-system. PC-BSD 10.2 - Derived off FreeBSD 10.2, the defaults were the Clang 3.4.1 compiler and ZFS file-system. In the SQLite test, PCBSD+ZFS won out over all of the Linux distros, including those that were also using ZFS In the first compile benchmark, PCBSD came second only to Intel's Linux distro, Clear Linux. OpenBSD can last, although it is not clear if the benchmark was just comparing the system compiler, which would be unfair to OpenBSD In Disk transaction performance, against ZFS won the day, with PCBSD edging out the Linux distros. OpenBSD's older ffs was hurt by the lack of soft updates, and DragonFly's Hammer did not perform well. Although in an fsync() heavy test, safety is more important that speed As with all benchmarks, these obviously need to be taken with a grain of salt In some of them you can clearly see that the ‘winner' has a much higher standard error, suggesting that the numbers are quite variable *** OPNSense 15.7.24 Released (https://opnsense.org/opnsense-15-7-24-released/) We are just barely into the new year and OPNSense has dropped a new release on us to play with. This new version, 15.7.24 brings a bunch of notable changes, which includes improvements to the firewall UI and a plugin management section of the firmware page. Additionally better signature verification using PKG's internal verification mechanisms was added for kernel and world updates. The announcement contains the full rundown of changes, including the suricata, openvpn and ntp got package bumps as well. *** Beastie Bits A FreeBSD 10 Desktop How-to (https://cooltrainer.org/a-freebsd-desktop-howto/) (A bit old, but still one of the most complete walkthroughs of a desktop FreeBSD setup from scratch) BSD and Scale 14 (http://fossforce.com/2016/01/bsd-ready-scale-14x/) Xen support enabled in OpenBSD -current (http://undeadly.org/cgi?action=article&sid=20160114113445&mode=expanded) Feedback/Questions Matt - Zil Sizes (http://slexy.org/view/s20a0mLaAv) Drin - IPSEC (http://slexy.org/view/s21qpiTF8h) John - ZFS + UEFI (http://slexy.org/view/s2HCq0r0aD) Jake - ZFS Cluster SAN (http://slexy.org/view/s2VORfyqlS) Phillip - Media Server (http://slexy.org/view/s20ycRhUkM) ***

Recently various city officials in Chicago effectiveness as leaders have been questioned once a judge ordered the release of a video tape showing a young man being shot 16 times by a police officer.  Since the release of this video many are left with many questions.....   Things to consider: What did Mayor Rahm Emanuel know and why was the decision made to settle with the family? What does this case reveal to us about the leadership of Chicago? What could city officials have done differently in the case of Laquan Mcdonald?   To Read: http://www.huffingtonpost.com/entry/rahm-emanuel-laquan-mcdonald_5655e2a2e4b072e9d1c15efb Join the conversation......        

Join us Sunday April 12, 2015 5:30 CST as we raise the questions: Choosing to marry and deciding to stay married…. What’s the benefit?  How should we support and encourage healthy relationships and marriages?  Today's host is not a stranger to the MTAS family. Les Rodgers is committed to public safety, the health of families, businesses and communities. Through ITC consulting and training he shares his passion, ideas and expertise in areas of effective communication and time management.  To add your voice and have your views heard please call 718-508-9555 Press #1 to speak your mind or always feel free to simply listen to the mind of others.   

Today on MTAS radio we will be discussing the necessity of life insurance and why you should never buy it!

Möt stå-uppkomikerna Kristoffer Appelquist, Peter Wahlbeck och konstnären Tom Friedman.                                                                                                                                              Visst går det att skämta om kriget i Afghanistan. Det menar i alla fall Kristoffer Appelquist som nästa vecka har premiär för sin nya ståuppshow Krig på Boulevardteatern i Stockholm. Kristoffer Appelquist navigerar mellan självmordskameler och kamikazefladdermöss. Och hans mål är att publiken ska skratta så att tårarna sprutar. Han har själv jobbat som fältartist i Afghanistan och ville sen använda sin plats i offentligheten till att prata om allvarliga saker som vad Sverige egentligen gör där borta i Asien. Är det verkligen fredsbevarande arbete eller är det så att Sverige för första gången på 200 år hamnat i krig? Och på Mosebacke Etablissemanget har komikerkollegan Peter Wahlbeck gjort en ny Cabaret Für Alle. En uppdaterad version av succéföreställningen för tio år sen. Här drivs med allt, högt som lågt. Om politik, andlighet, plumphet, surrealism ackompanjerat av musik. Anneli Dufva och Cecilia Blomberg har träffat de här två aktuella stå-uppkomikerna. Lekfullhet är en annan ingång till samtiden. På Konsthallen Magasin 3 i Stockholms Frihamn visas just nu en stor utställning med den amerikanske konstnären Tom Friedman. I en stor installation har han hängt en massa grejer i tunna nylontrådar från taket. Det blir som en egen galax av bjärt målade nonsensföremål, hamburgare och pizzakartonger, pickadoller och konsthistoriska ikoner. Karsten Thurfjell har träffat Tom Friedman. Programledare: Cecilia Blomberg

Title: The Next Generation Cable Network: DOCSIS 3.0 Intro: The first DOCSIS standard, short for Data Over Cable Service Interface Specifications, standard was released by the company Cable Labs in 1997. In this podcast we take a look at the history of these standards and discuss DOCSIS 3.0 – the emerging standard in the cable industry. Mike: Gordon, can you give us a brief history of the first DOCSIS standards? Gordon – just covers up to 2.0 Mike: What are “tiered services?? Tiered services is business jargon for providing a service (such as telecom connectivity or cable channel service) according to separate, incrementally distinct quality and pay levels, or "tiers." We’re seeing this term used a lot recently in political debate regarding “net neutrality?. Mike: Can you tell us a little more about DOCSIS 3.0? Sure – in a nutshell it’s bigger, better, faster… It’s a needed response to products from competitors like Verizon with FIOs FTTH product and AT&T with the FTTN Lightspeed product. It’s triple play broadband – voice video and data. DOCSIS 3.0: - Much higher bandwidth through channel bonding - Starts at 160 Mbps Downstream, 60 Mbps Upstream and goes up from there    - TI just rolled out their Puma 5 chip set a couple of weeks ago for cable modems. The chipset supports new DOCSIS 3.0 features, such as channel bonding, enable ultra high downstream bandwidth rates of at least 160 Mbps in the residential data and voice services configuration and 320 Mbps in video and business services configuration. In addition Puma 5 also supports greater quality of service with IPv6 and security with Advanced Encryption Standard (AES). - Multiple 6 MHz (or 8 MHz) channels are bound, treating them logically as one Channel bonding in both upstream and downstream - IPv6 for advanced networking capabilities - Expanded address space (2128 or 3.4 dodecillion) Improved operational capabilities Mike: How will IPv6 be rolled out? There’s a lot of speculation now but it looks like it will be in to phases. John T. Chapman and Shalabh Goel from Cisco Systems have an interesting piece we’ve got linked in the shownotes (http://www.cable360.net/ct/sections/features/20942.html ) “The initial deployment phase allows the cable operator to set up an IPv6 control and management plane for managing the cable modems, set-top boxes, and multimedia terminal adapters (MTAs) with a cost-effective upgrade. In a subsequent deployment phase, cable operators can offer IPv6 directly to the home network. Many new devices are already IPv6 capable, and cable operators could soon be running the largest IPV6 networks in the world.? Mike: What are some other key features of DOCSIS 3.0? Other key related DOCSIS 3.0 features, which may be migrated over time, include: • Enhanced security, including advanced encryption standard (AES), security provisioning and theft of service features; • An upstream frequency range extension to 85 MHz and a downstream frequency extension to 1 GHz that allows an operator to add existing capacity with plant upgrades at a later date; • Enhanced plant diagnostic features, including a cable modem diagnostic log, enhanced signal quality monitoring, extension of IP data record (IPDR) usage and capacity management. Mike: How about the commercial services? (from: http://www.cable360.net/ct/sections/features/20942.html) DOCSIS 3.0 specifications define two technologies for business services over DOCSIS: layer 2 virtual private networks (VPNs) and T-1 circuit emulation. Business users will be able to videoconference from their PCs and PDAs and tap into corporate networks through VPNs; residential customers will subscribe to video-on-demand (VOD) and IP telephony services with low latency and minimum packet loss; and users everywhere will be able to upload and download files at much greater broadband speeds. Mike: When will it be available? Comcast demo’ed 150 Mbps at the May 14, 2007 Cable Show in Las Vegas. “The Associated Press described a demo in which a 30-second, 300MB television commercial was downloaded in a few seconds, while a standard cable modem took 16 minutes?. “Also downloaded, in less than four minutes, was the full 32-volume Encyclopedia Britannica 2007 and Merriam-Webster’s visual dictionary. With a standard cable modem, that download would have taken three hours and 12 minutes (dialup would have taken 2 weeks)?. “Comcast is currently trialing this in the Boston area. In one trial, the cable operator will set up an IP video headend to experiment with carrying voice, video and data over a single IP connection?. According to FierceIPTV (http://www.fierceiptv.com/story/comcast-to-trial-docsis-3.0-iptv/2007-05-08 ): “Comcast's planned converged-services trial will take place in a system that serves 50,000 homes, and will include an IP-video headend and DOCSIS 3.0 STBs, as well as the Slingbox from Sling Media, dual mode WiFi-cellular handsets and mobile phones capable of playing video.? According to Chapman and Goel: The industry consensus is that fully compliant DOCSIS 3.0 CMTS* implementations will be available in 2008 to 2009. Many cable operators will require the most critical DOCSIS 3.0 features, such as downstream channel bonding and IPv6, far earlier. To meet this demand, many vendors’ CMTS products now include early implementations of such a subset of DOCSIS 3.0 features. * CMTS: A cable modem termination system or CMTS is equipment typically found in a cable company's headend, or at cable company hubsite and is used to provide high speed data services, such as cable internet or Voice over IP, to cable subscribers. In order to provide these high speed data services, a cable company will connect its headend to the Internet via very high capacity data links, also known as a circuit (canonical form of telecommunication circuit), to a network service provider. On the subscriber side of the headend, the CMTS enables the communication with subscribers' cable modems. Different CMTSs are capable of serving different cable modem population sizes - ranging from 4,000 cable modems to 150,000 or more. A given headend may have between half a dozen to a dozen or more CMTSs to service the cable modem population served by that headend. One way to think of a CMTS is to imagine a router with Ethernet interfaces (connections) on one side and coax RF interfaces on the other side. The RF/coax interfaces carry RF signals to and from the subscriber's cable modem. (source: http://en.wikipedia.org/wiki/CMTS )