Podcasts about SEQ

This was one of the most highly anticipated and highly attended webinars of the year — and for good reason. In this exclusive session, Hotspotting founder Terry Ryder and iBuyNew CEO Daniel Petersen explore the powerful impact the 2032 Brisbane Olympic and Paralympic Games will have on property markets across South East Queensland. ✔ Learn from case studies of past Olympic host cities, including Sydney, Athens, London, and Tokyo ✔ Discover how infrastructure, population growth, and legacy planning have driven real estate booms ✔ Understand why Brisbane is poised to outperform every other Australian city over the next decade ✔ See the key suburbs and property types set to benefit most ✔ Preview real investment opportunities in Kangaroo Point and Milton, Brisbane Whether you're a first-time investor or building a portfolio, this session will help you understand why the time to act is before the Olympic flame is lit.

Steganography Challenge Didier revealed the solution to last weekend s cryptography challenge. The image used the same encoding scheme as Didier described before, but the columns and rows were transposed. https://isc.sans.edu/forums/diary/Steganography%20Challenge%3A%20My%20Solution/31912/ FBI Warns of End-of-life routers The FBI is tracking larger botnets taking advantage of unpatched routers. Many of these routers are end-of-life, and no patches are available for the exploited vulnerabilities. The attackers are turning the devices into proxies, which are resold for various criminal activities. https://www.ic3.gov/PSA/2025/PSA250507 ASUS Driverhub Vulnerability ASUS Driverhub software does not properly check the origin of HTTP requests, allowing a CSRF attack from any website leading to arbitrary code execution. https://mrbruh.com/asusdriverhub/ RV-Tools SEO Poisoning Varonis Threat Labs observed SEO poisoning being used to trick system administrators into installing a malicious version of RV Tools. The malicious version includes a remote access tool leading to the theft of credentials https://www.varonis.com/blog/seo-poisoning#initial-access-and-persistence

Managing our emotional state—by finding calm and focus—is essential before we can effectively plan or take action. If we're emotionally overwhelmed, our minds "swirl" and we lose clarity.Eric here. I welcome back Jim and Lynette Vaive for an insightful discussion about how SEQ can help us navigate uncertainty, disruption, and the complexities of modern times.From the looming impact of AI on the workforce to the inner crossroads of meaning and purpose, we explore practical ways to develop resilience and clarity. Discover why mere thinking isn't enough to process our deepest worries, and how integrating spiritual, emotional, and intellectual awareness can unlock growth and connection.Together, we discuss the stages of personal development, the power of intention at life's crossroads, and the benefits of supportive community—along with real-world strategies and tools (like assessments and group cohorts) you can use to strengthen your own SEQ “muscle.” Whether you're just curious, seeking meaningful change, or feeling called to something deeper, this episode offers wisdom, encouragement, and tangible pathways forward.Here are 3 key takeaways you can apply right now:Recognize Your Crossroads: Points of uncertainty or disruption are invitations, not dead ends. SEQ helps us see choice and growth where we might otherwise see obstacles.Balance More Than Your Mind: Navigating complexity isn't just about thinking harder—it's about blending intellect with emotional and spiritual awareness to stay grounded and focused, especially in stressful times.Connection is the Catalyst: Whether through communities, assessments like the Enneagram, or simple reflection, building SEQ is most powerful when shared. There's no one-size-fits-all—find your starting place and the people who will walk alongside you.Key Moments00:00 Understanding SEQ Amid Global Uncertainty04:36 Spiritual Foundations Amid Life's Complexity09:03 Calmness Unveils Ignored Issues10:04 "Navigating Profound Conversations"15:40 "Managing Emotions Quickly"17:01 Intention and Cultural Priorities20:46 Politics' Unintended Place in Soul24:53 "Cohort Dynamics Explained"27:26 Hiking Adventure at Mount Rainier31:53 "Three-Mile Rest Spot"34:35 Personalized Development Tools Access38:42 "Guiding with Empathy and EQ"41:33 "Guidance and Support Offered Freely"43:06 "SEQ: Enhancing Personal and Global Connection"Spirit of EQ In each episode, Jeff and Eric will talk about what emotional intelligence, or understanding your emotions, can do for you in your daily and work life. For more information, contact Eric or Jeff at info@spiritofeq.com, or go to their website, Spirit of EQ.You can follow The Spirit of EQ Podcast on Apple Podcasts, Android, or on your favorite podcast player.New episodes are available on the 2nd and 4th Wednesdays every month!Please review our podcast on iTunes. Click on the link for an easy, step-by-step tutorial.Music from Uppbeathttps://uppbeat.io/t/roo-walker/deeperLicense code:...

In this episode we discuss the ramifications of of all the rain that we've had in SEQ and how it will affect the coming weeks. We also touch upon the Roar and how they can improve moving forward.

Send us a textNot much happening around SEQ in terms of trail running but a wrap up of the SEQ Season plus some coverage of the Backyard Ultras in Roma and Sydney with some local runners on the start line.Support the showThanks for your Support!!

A big shoutout to our fellow SEQ home schoolers. This episode was loaded before Alfred hit (right now he's slow and changing his mind every few hours). We hope everyone is as safe as they can be in the post effects of TC Alfred. We are hunkered down with you waiting around This week's episode is all about the wobbly wobbles. When you have concerns that things aren't going as well as you hoped or you are feeling the hot end of burn out - just know it is going be ok. We said we would talk about all the aspects of home schooling when we created this podcast and this episode certainly talks about the harder moments of this educational journey we have chosen for our little loves. Big hugs xThanks for listening!We would love to answer your questions and help you share your stories.Write to us at:hello.sisterswhohomeschool@gmail.comFollow us at:FacebookInstagram

The area commander for Mackay & The Whitsundays is in SEQ helping residents there prepare for the oncoming tropical cycloneSee omnystudio.com/listener for privacy information.

Today's podcast is a special edition for our SEQ mates preparing for Cyclone Alfred. Bronte and Lakey chat to QLD Premier David Crisafulli, Cr Donna Gates (Deputy Mayor) and have other handy resources during this Cyclone.Subscribe on LiSTNR: https://play.listnr.com/podcasts/seafm-gold-coast-breakfastSee omnystudio.com/listener for privacy information.

Sometime on Tuesday Cyclone Alfred is expected to turn towards SEQ.. as it inches closer to the coast. It's still not clear exactly WHERE or WHEN it could make landfall. Meteorologist Jonathan How says they're expecting it to hit somewhere between Brisbane and the Sunny Coast on Thursday Night or early Friday.See omnystudio.com/listener for privacy information.

ADULTS ONLY | The producers have organised a little surprise for the gang and no insect in SEQ is safe.See omnystudio.com/listener for privacy information.

SEQ band SGO shine with their second album which was released in November 2024, and they give us a song-by-song run down of their tracks – we include 2 here, and it is absolutely delicious! What a delight… we had to wrap this up with other Aussie bands to present it to you as a pre-holiday treat. You will be all kinds of impressed and can check out the full album run-down on demand. Also included -> Pyrex, Lone Seagull, Hyla, Hey Calamity, Sacred Hearts, blue diner., Paint, Sorry,Dave, and Total Tommy. Looking down is looking up!For more info and tracklisting, visit: https://thefaceradio.com/shoegrazzzeTune into new broadcasts of ShoegraZZZE, Mondays from 11 PM - 1 AM EST / 4 - 5 AM GMT (Tuesday)//Dig this show? Please consider supporting The Face Radio: http://support.thefaceradio.com Support The Face Radio with PatreonSupport this show http://supporter.acast.com/thefaceradio. Join the family at https://plus.acast.com/s/thefaceradio. Hosted on Acast. See acast.com/privacy for more information.

There are multiple reasons why Australia has a housing shortage and why the numbers of new dwellings needed are simply not being built. This is something I have spoken about regularly in the past and will continue to do so, as it's the core issue creating problems for real estate consumers of all kinds – home buyers, investor buyers and tenants. Here are the latest events and announcements which help to explain why we have a housing shortage with rising prices and rising rents, problems which are not going to be fixed in the foreseeable future … ITEM 1 – BUREAUCATIC DELAYS: Sydney councils are sitting on backlog of almost 8,500 unresolved development applications and requests for development certificates, according to NSW government data. There are over 5,000 unresolved development applications across the Greater Sydney area, plus 3,300 active “complying development certificates”. Five councils each have more than 300 local development applications that are waiting to be finalised. Data from the Department of Planning Housing and Infrastructure lists the Inner West Council as the worst offender, with 456 “active” DAs waiting for a determination. The Northern Beaches, Hills Shire and Cumberland Councils also have major backlogs. Thousands more “complying development certificates” are also adding to the backlog, despite being designed to give faster approvals to developments that meet certain requirements. Some councils are taking more than a year to approve homes. And some developers are waiting up to a decade for projects to be approved. In my view, one of the core issues is that many councils have a NIMBY attitude to development, especially high-density residential. They simply don't want developments to be built and do everything they can to frustrate builders. ITEM 2 – NOT FINANCIALLY VIABLE: In Perth, the rate of apartment completions has dropped to its lowest levels since records began in the 1980s. A new Property Council report says that, to meet the housing targets set by the National Housing Accord, WA would need to be delivering five times the number of apartments per year that it currently is. The Sky High report says there are more than 10,000 apartments approved for WA but effectively on hold and unable to be constructed. The major issue is that projects are just not financially viable – because the cost of delivering an apartment is generally higher than the market is willing to pay, so projects simply don't stack up. Only luxury apartments are economically viable projects. The report blames climbing construction costs - driven by labour shortages and competition for labour from government and mining sectors. The report says: “Developers are reporting that construction cost estimates are now almost double the cost of similar developments five years ago.”  The Property Council expects that costs will climb even higher as the new national construction code and bargaining agreements imposed by government take effect. This is problem not only in Perth but right across Australia. Developers are scrapping unit projects because the costs are so high, making them financially unviable. The Australian Construction Industry Forum says it's a worrying trend for a country that needs more, denser homes – not only apartment towers but medium-rise and townhouse developments in existing suburbs – to tackle the chronic undersupply of housing and to ensure longer-term affordability. The forum's Construction Forecasting Council chair and chief economist Nerida Conisbee says: “It's very, very expensive to build apartments. Many projects aren't going ahead.” ITEM 3 – WORKER SHORTAGES: A recent report reveals that Australia needs 130,000 additional workers to combat labour shortages in the construction sector. This has prompted calls for rapid reforms from both federal and state governments to attract and retain skilled labour. The report says the nation is on track, in 2024, for the worst year in new home builds in over a decade, with an 9 per cent decline in new building starts, totalling just 158,000 when it needs to be 240,000 per year to meet the Federal Government's fanciful target of 1.2 million new homes in five years. Construction starts for detached houses have dropped by 10 per cent, while higher-density projects have declined by 6 per cent. If this pace continues, Australia could see fewer than 800,000 new home starts over the five years, leading to a shortfall of over 400,000 homes compared to the National Housing Accord target. The decline in apprenticeship numbers further compounds this crisis, with completions down 8 per cent and commencements down 12 per cent in the past year.  ITEM 4 – POLITICAL POLICIES: The Housing Industry Association says a home building recovery is possible because buyer demand is rising, but state government housing policies risk stalling the revival. HIA Senior Economist, Matt King, says demand for new homes nationally is accelerating - largely due to high population growth, low unemployment, stable incomes and the absence of interest rate rises for the past year. King says activity generally is picking up, but there are big differences across capital city and regional markets. Sydney remains an outlier and there is still no indication of a near-term rebound in residential building in the big city. King says: “New home building in the Sydney basin remains exceptionally low, primarily due to high land prices and excessive housing taxes and infrastructure charges.” Australia-wide, the HIA says the detached home building sector looks promising, but the unit sector remains constrained and is unlikely to experience recovery before mid-2025.  King says: “The sector continues to be dampened by skilled labour shortages, business credit constraints and the aftermath of significant building material cost escalation.  “The extent of the recovery in new home building will be determined by the ability of governments to ease the barriers to home building. “Recent state government plans to increased surcharges on foreign investors and introduce taxes on short-term rental accommodation are unhelpful at a time when stability is needed to achieve the target of 1.2 million homes.” King says the rate of home building is being slowed down by government failure to implement policies such as expedited land releases, concessions on property taxation, and accelerated development approval time frames. ITEM 5 – HIGH LAND COSTS:  The rapidly prising cost of home sites is one of the biggest barriers to easing the housing shortage. New figures for South East Queensland indicate that the cost of residential home sites has jumped by as much as $120,000 in a year – up 21 per cent in one LGA where it now costs as much for a block of land as the median home did just two years ago. This is the City of Brisbane LGA where land prices rose 8.7 per cent in the September quarter alone, pushing the median price of a block of land to $685,000 – which is $3,000 more than what an established home cost in this area in June 2022. The second biggest annual surge in land prices occurred in the City of Ipswich where the median block rose 15 er cent or by $48,000 to hit $360,000, with the third fastest pace set by Moreton Bay, where prices rose by 10 percent to $415,000. The cheapest blocks of land in South East Queensland are in Logan City in Brisbane's south, where a third of SEQ land sales are now occurring – with the median price at $350,000 after a rise of almost 10 percent across the year.  The Gold Coast had the second highest SEQ land price at $619,000, after an 8 percent rise in the past year. So, you can imagine what a new house on a block of land costs, when the land alone costs well over $600,000 – as it does in the City of Brisbane and on the Gold Coast. Why does it cost so much? Primarily because of bureaucratic delays, governments taxes fees and charges, and high interest rates – all problems created by our elected representatives.  

Ses photographies sont un appel au voyage au large de la Méditerranée, une invitation au rêve et une célébration de l'insouciance estivale. Si ses œuvres éveillent autant notre imaginaire, c'est parce qu'elles ne sont pas si communes... Cette photographe a développé une technique de surimpression argentique. Elle fait s'entremêler les prises de vue, se rencontrer des images qui se superposent sous nos yeux. Le résultat est onirique, réalité et fantasme fusionnent, c'est alors à nous d'ouvrir notre « musée intérieur », comme elle aime l'appeler, pour accueillir et réinterpréter ses créations. L'Italie, et plus particulièrement la baie de Naples, Rome, ou encore Ponza sur les îles Pontines, sont une source d'inspiration continue, que Joséphine Vallé Franceschi nourrit derrière son objectif. Bell'ascolto !· L'univers photographique de Joséphine :Instagram : @josephinefranceschiSite Internet : www.josephinevallefranceschi.frCollectif d'artistes féminines « Le cercle de l'art » : @lecercledelart / www.lecercle.artGaleries où découvrir ses œuvres : @galerie_larock_granoff @matchi.art_Prochaines expositions : en novembre à la galerie @ldg.art.patrimoine et en décembre à Casablanca à l'@edenart.gallery !· Les inspirations italiennes de Joséphine :Le port de Bastia inspiré de l'architecture génoise, les maisons « d'américains » du Cap Corse qui rappellent les palais toscans.Le film « Plein soleil » de René Clément, avec Alain Delon, tourné entre Ischia et Procida, ainsi qu'à Rome. La BO du film signée Nino Rota. Ainsi que, le célèbre voilier du film « Le Marge » amarré dans le port de Marseille.Les cinémas du quartier latin à Paris, comme « Le Champo », qui rediffusent les films cultes italiens.A Rome, le Palais Farnèse, siège de l'Ambassade de France en Italie. Les plafonds du bureau de l'ambassadeur à observer de nuit depuis la place du Palais, et découvrir le Salon d'Hercule, la galerie des Carrache & la Villa Médicis.Le Palazzo Spinelli à Naples, l'adresse secrète des artistes, tenu par Nathalie de Saint Phalle qui a inspiré son exposition « Le Secret bleu de Monsieur Kaplan ».L'antiquaire Antica Libreria Cascianelli à Rome, où trouver de vieilles photographies inspirantes.Conçu, réalisé et présenté par Claire PlantinetMontage Générique : François PraudMusique : Happy Clapping Cinematic Score / PaBlikMM / Envato ElementsCréation visuelle : Thomas JouffritPortrait © Joséphine Valle FranceschiPodcast hébergé par Ausha.· Archives épisodes :© Extraits BO « Plein soleil » par Nino Rota – Thème principal et du marché aux poissons à Mongibello – Film « Plein soleil » (Paris Films Production, Titanus, Studio Canal, Carlotta films) – Documentaire « Roma, Santa e Dannata » de Roberto D'Agostino et Marco Giusti, « La plage » de Marie Laforêt – « Amore In Controluce » (Seq. 3) de Gianni Marchetti.· Contattami, Scrivimi !Retrouvez allora sur Instagram @allora.lepodcast & Facebook @alloralepodcast !Hébergé par Ausha. Visitez ausha.co/politique-de-confidentialite pour plus d'informations.

Welcome back to the APS News Bulletin, your source for the latest updates and insights from the Australian property market. Join Sammy Gordon, as he breaks down this week's most pressing updates and announcements along with his expert analysis to keep you informed and on top of news.    In this week's episode, Sammy reports and discusses: Slim Pickings! Low supply, high demand keeps the market hot in SEQ! Banking giant NAB cuts 3-year fixed mortgage rate If you enjoyed this episode, please write in and let us know! If you have any news you'd like Sam to share his point of view send us an email at apsteam@australianpropertyscout.com.au. If you loved this episode please send it on to someone who would take some value, and please give us a 5 star review if you haven't yet and are loving the poddy! If you're taking tremendous value from these episodes why not share them with your mate? If you want your question answered on our podcast DM us on our socials or email us at apsteam@australianpropertyscout.com.au Send us your questions to: Instagram: @australianpropertyscout Want to book a call with us: Website: https://australianpropertyscout.com.au Any information, comments, opinions or content that we provide in this podcast is our general observations and information only and it is not to be taken as, or in any way, considered to be financial advice, accounting advice, superannuation advice or legal advice. We strongly recommend all and any listener and participant to obtain their own independent financial advice, accounting advice, superannuation advice and legal advice before acting in any way in relation to any investment at all including any investment in property such as what we might be discussing in this podcast. No warranty, guarantee or representation is to be taken and you cannot reproduce it in any way. Every persons financial or investment situation is different and you must consider your own circumstances before undertaking any investment and be sure to obtain independent advice. Australian Property Scout Pty Ltd | License Number: 10094798 | ABN: 64 638 266 369

The team has been decimated and plenty of different faces playing out of position this morning. We catch up with the SEQ busker who's gig got crashed by Teddy Swims and Buzz is forced onto the streetsSee omnystudio.com/listener for privacy information.

Cocaine is everywhere is SEQ and Stephen Drill takes us behind the scenes with Cocaine Inc. Plus, Origin Fashion Statements, shocking tatts and why loaning tools is a bad idea!See omnystudio.com/listener for privacy information.

Home builders and property developers make their money creating new dwellings for Australian households. If they get it right, they can make lots of money doing what they do. When they decide NOT to do what they do, you have to ask why. Why are the builders of major projects of housing or apartments walking away from their plans? Why are big companies who have spent years and millions of dollars planning a major project making the decision not to build it? We've seen many instances recently. An example is the decision by AVJennings to abandon a major housing development near Caboolture in the outer northern suburbs of Greater Brisbane. This project would have added 3,500 new homes to a market where there is a desperate shortage. Brisbane is a market with high demand and a serious shortage of homes. Why would a big developer with a proven track record and the capacity to deliver these kinds of projects make the very big decision to walk away from the project? All that time and money wasted. The answer is: it's simply not viable. AVJennings said massive cost escalations – including the infrastructure charges and delays in getting approvals imposed by local councils – meant the project was no longer viable. I have had discussions recently with developers who say that the cost of creating big residential projects is so high, it's not economically and financially feasible. They would have to place such a high price on the end product that few households would be able to afford to buy the homes. A number of developers have spoken out about the impact that the cost impositions of local councils have on making projects difficult or unviable. Orchard Property Group managing director Brent Hailey says the major infrastructure costs imposed on them make it too expensive for them to build homes. Hailey said that, for example, developers in that Caboolture West precinct that AV Jennings has rejected had to pay for council infrastructure charges and also state government charges because it's in a Priority Development Area. Hailey says: “We're at this point now in SEQ where unless the solutions are put in place quickly, there's going to be a rapid decline in affordability, forced by supply not meeting demand.” He says: “The problem facing developers is the cost of delivering the infrastructure and the balance between fully servicing those costs and trying to get an affordable home. There's the normal council charges and the Priority Development Area (PDA) charges. During Covid-19 costs went through the roof, so now infrastructure is costing a lot more.” Here's another issue which is preventing the creation of affordable homes in Australia. Prime Minister Anthony Albanese's pledge to build 40,000 affordable homes through the Government's $10bn housing fund will struggle to deliver any houses at all in Labor's first term of office because only a handful of builders in Australia are eligible to participate in the program. Rules written into the Housing Australia Future Fund legislation require builders contracted to work on new social and affordable homes under the scheme to be accredited for working on government-funded projects. However, of the more than 400,000 construction companies registered in Australia, only around 500 are accredited by the Federal Safety Commissioner under the Work Health and Safety Scheme for eligibility to bid for head contracts funded directly or indirectly by the government. There are few if any residential builders accredited under the scheme in Tasmania and only a limited number in regional Australia. The industry claims the limitation threatens to severely hamper or stall Housing Australia's ability to deliver its target of 40,000 social and affordable homes. This comes at a time when the new construction code being imposed by governments is adding $30,000 to $40,000 to the already-high cost of building new homes in Australia. These are just the latest events adding to a substantial list of situations which create the inevitable conclusion that we have a serious housing shortage in Australia, and very expensive new homes in this country, because of the short-sighted policies of politicians at all levels of government.  

Patricia O'Callaghan, Tourism & Events Queensland CEO, joined Peter Gleeson on 4BC Drive to discuss the state's tourism campaigns that have been launched to supersize Queensland's global reputation and what she thinks about bringing Disneyland to SEQ.See omnystudio.com/listener for privacy information.

The 2024 Premium Cigar Association (PCA) Trade Show was special for Aric Bey and Black Star Line Cigars. This year, the company is celebrating its five-year anniversary. To mark the occasion, a special five-year anniversary cigar, the Marun, is coming out. In addition, two of the company's core lines, Lalibela and Dark War Witch, are getting line extensions. PCA 2024 Report: https://wp.me/p6h1n1-sEq

The 2024 Premium Cigar Association (PCA) Trade Show was special for Aric Bey and Black Star Line Cigars. This year, the company is celebrating its five-year anniversary. To mark the occasion, a special five-year anniversary cigar, the Marun, is coming out. In addition, two of the company's core lines, Lalibela and Dark War Witch, are getting line extensions. PCA 2024 Report: https://wp.me/p6h1n1-sEq

Racing New's 2023 Trail Runner of the Year Billy Curtis steps off the rugged terrain and into our podcast studio, sharing the heartbeat of his journey from the team huddles of rugby league to the independent peaks of trail running. As Billy opens up about the intricacies of juggling life as a student, farmer, and now trail co worker, it's evident that his story is not just about athletic prowess but a testament to the balance of dedication across all facets of life. We explore the essence of his training, his early race days, and how his rugby background has been an unexpected asset in the world of solo running.Venture with us through Billy's exhilarating trail racing adventures, where each race is a chapter filled with strategic confrontations and personal victories. From an eye-opening first race at the Glasshouse 50 to his tactical success at renowned events like the SEQ series and the UTA 22km, Billy recounts the pivotal moments and the highs and lows of competing against both the course and the clock. His global race ambitions come alive as he reminisces about the grueling 50K in Borneo and the Ultra Trail Kosciuszko, painting a picture of the sheer determination required to excel in this demanding sport.As we edge closer to the starting line of upcoming races, Billy, Kyle and Tom trade predictions and tips from our trove of trail tales, offering a glimpse into the riveting world of competitive trail running. The Golden Trail Series looms on the horizon, promising stories of triumph and the relentless spirit of runners like Billy and the community's legends. His gratitude for being part of the conversation resonates with each of us who turn passion into footsteps on the trail. Join us for an episode that's as much about the inner journey as it is about the outer miles.Support the showThanks for your Support!!

Lee is back this month with a mix of music selections from Italian action films from the 1980s. There's some superhero antics, some comedic slapstick action, late period poliziotteschi, and items that fall under the "macaroni combat" moniker. The list is both light and breezy, and in some cases, maybe a bit tight and sleazy. Enjoy! --Seq. 2 & Seq. 10 from "Speed Driver" (1980) --Stelvio Cipriani --Seq. 14 from "The Rebel" (1980) --Stelvio Cipriani --Main Title from "Strike Commando" (1987) --Luigi Ceccarelli --Main Title from "Blastfighter" (1984) --Fabio Frizzi --What's Going on in Brazil (Jazz Band) from "Double Trouble" (1984) --Franco Micalizzi --Supersnooper from "Super Fuzz" (1980) --The Oceans --The Puma Man & Puma Man #7 from "The Pumaman" (1980) --Renato Serio --Transformation Version 2 & Starlights from "Endgame" (1983) --Carlo Maria Cordio --The Day of the Cobra from "The Day of the Cobra" (1980) --Paolo Vasile & Charlie Cannon Opening and closing music: Main Title from "Battle Beyond the Stars" by James Horner, and Main Theme from "The Final Terror" by Susan Justin.

Happy new year and welcome to 2024! In this episode of SYF Podcast, we have Tom Rivera from Property Works QLD joining our property segment host David Shih to go through the market update in SEQ including: - On the ground sales & rental market update - Why property investors are looking at SEQ/Logan market again - Is Logan starting to gentrify? - Latest legislation & what you need to know as SEQ landlords - 2024 Prospects for SEQ market  And much more! --- DISCLAIMER:  Host/Guest are not Financial Adviser/Investment Consultant. All opinions expressed by host or his guests are for informational purposes only and should not be treated as investment/financial advice of any kind.  "Spark your FIRE" and its team are not liable to the listeners or any other party, for the listeners use of, or reliance on, any information received, directly or indirectly, from the content in any circumstances. Please conduct your own research and obtain independent legal, financial, taxation and/or other professional advice in respect of any decision made in connection with this audio. Contact -  sparkyourfirepodcast@gmail.com

Measuring a user experience can be intimidating at first, but it's an essential part of determining whether your work is moving in the right direction (and by how much). UX Master Certified Dr. John Pagonis shares his experiences from working with other organizations on measuring UX improvements and interpreting quantitative data. Learn more about John Pagonis: Connect on LinkedIn Watch a past keynote talk: Usefulness measurement: A practical guide for all UXers (37 min video)⁠ NN/g Articles, Videos, and Reports about Usability and UX Metrics: Usefulness, Utility, and Usability by Jakob Nielsen, PhD (2-min video) The UX Unicorn Myth (decathlon analogy, explained, 2-min video) Usability 101 by Jakob Nielsen, PhD (free article) ⁠UX Metrics and ROI by Kate Moran⁠⁠ (297-page report) NN/g Articles about Microsoft's Desirability Toolkit and Adjectives List ⁠Using the Microsoft Desirability Toolkit to Test Visual Appeal⁠ (free article) ⁠Microsoft Desirability Toolkit Product Reaction Words⁠ (free article) Jeff Sauro, PhD on UX-Lite, UMUX-Lite, SUS, SEQ (an aside: his website, MeasuringU.com, is an excellent resource) 10 Things To Know About The Single Ease Question (SEQ) Measuring Usability with the System Usability Scale (SUS) 5 Ways to Interpret a SUS Score Measuring Usability: From the SUS to the UMUX-Lite ⁠Evolution of the UX-Lite⁠

Marla Albertie - Truth Speaks Coaching Telling It How It Is: "But you gotta think about you. We all get burnt out. Everybody. I don't I don't care who you are. Everybody has gotten burnt out or will get burnt out." Every business owner, at some point, gets to start feeling a little burnt out.  This can lead to crazy thoughts, including the dreaded imposter syndrome, or maybe even going back to being an employee (maybe not that bad). Marla Albertie, a seasoned business coach and expert in career development gets down to business and shares some nuggets of wisdom to prevent this from happening. Marla shares her story of transitioning from a career in financial planning to becoming a sought-after coach. She takes us through her journey of discovering her passion for coaching and the certifications she obtained to enhance her skills. Marla emphasizes the importance of having a personalized coaching philosophy and shares her unique approach, known as SEQ - strategic, empathetic, and unscripted questioning. She believes in the power of organic conversations and the transformative partnership between coach and client. As we dive deeper, Marla opens up about the challenges faced by African American women in the workplace and how it can contribute to burnout. Listen as Marla takes us on a journey to explore the concept of essentialism and how it relates to finding fulfillment in life. Enjoy! Visit Marla at: https://www.truthspeakscoaching.com/ Podcast Overview: [00:02:21] Resume writing, coaching, certifications, continuous learning, author. [00:08:05] Changed pricing and developed coaching philosophy. Constantly evolving. [00:13:06] How to avoid discipline: aim for 3. [00:21:02] Care about employees' personal lives and concerns. [00:26:58] Burnout from pressure to continuously perform well. African American women face unique challenges. [00:28:57] C-suite role adds pressure, debunking burnout. [00:38:39] Overwhelm: Story of Wright Brothers and Perspective [00:42:22] Social media's influence on younger generations. [00:49:32] You're allowing bullying, stop commenting and stressing. [00:55:41] CDs, parents buying, public figure challenges, human being. [00:59:05] Beyonce fan but prioritize self and others. [01:06:08] "Do your research, know the why." Podcast Transcription: James [00:00:00]: You have found authentic business adventures, the business program that brings you the struggle stores, and training successes of business owners across the land. We are locally under by the Bank of Sun Prairie. My name is James Kademan, Entrepreneur, author speaker and helpful coach to small business owners across the country. And today, we're welcoming slash preparing to learn from Marla Albertie, the founder of Truth Speaks Coaching, which I'm excited to talk about Marla today because she delves into the psychology, which is let's just face it. It's just how her brain works. So Marla, how are you doing today? Marla Albertie [00:00:33]: Oh my gosh. I am excited, super excited to be here, and and like you said, dive right in. And and it's funny you mentioned the truth based coaching because that's the website www.truespeaks coaching. James [00:00:45]: Interesting. Okay. Marla Albertie [00:00:46]: But the but the group, but but the title of the business is true speaks group. Because I changed it because I do so many things. James [00:00:52]: Oh, nice. Alright. Very cool. So let's just start with the name. Truth speaks. I can infer what it means. But why don't you just elaborate on that for us? Marla Albertie [00:01:01]: Oh my gosh. That is funny. You asked that question. I have a funny story about that. So I I had always wanted to be an entrepreneur from a little kid growing up. So but I was in a process when I was married last. I was, thinking of a speaking company for my husband and his friend. So I said, you know what? Let's name it.

We go into how car crashes are a go to for neutralizing a threats and the capabilities of the US to engineer them, and how the public is passified by this for as car crashes seem like serendipity, and not an engineered assassination // www.Cointelpro2zero.com Moduro Drone Assassination Attempt: https://twitter.com/MintPressNews/status/1688549526565531648?t=o-8xCPku5rK95xsT6xf0eQ&s=19 CIA Assassination of Julian Assange: https://www.dailymail.co.uk/news/article-10030397/CIA-secret-plans-kidnap-assassinate-Julian-Assange-2017-ex-officials-say.html Car hacking: https://youtu.be/X45Bb8O-gMI R-9x: https://youtu.be/IoKJ6Sp-B0o SD surveillance drones: https://www.forbes.com/sites/davidhambling/2020/07/02/secret-drone-flights-over-san-diego-raise-surveillance-concerns/?sh=13bf94623d6b SpoilNet: https://meshnewsdotorg.blogspot.com/2020/12/spoilnet-scary-real-time-censorship.html?m=1 Military blimps: https://youtu.be/72UC3ubJICw Blackwater Cops: https://odysee.com/@MeshClips:f/How-Blackwater-is-structured:a?r=GxeLZCGejrzyx76Y6NSACsUBu6DuQvU9 Military laser: https://youtu.be/XKwRI9CmCBM Laser Range: https://en.m.wikipedia.org/wiki/AN/SEQ-3_Laser_Weapon_System 118 degrees: https://youtube.com/shorts/loJY3Uk7cis?feature=share Military Drone Shot Down Laser: https://www.overtdefense.com/2019/08/21/turkish-laser-downs-chinese-built-uae-operated-uav-in-libya/ Anne Heche: https://youtu.be/tB-s7QJ23yA

Lee is back with part one of a two-part look at the soundtracks and scores of sex comedies, specifically those of the 1970s and 1980s, the raunchier the better! There was so much material to go through that he had to split each decade into its own super-sized episode of BotT, and even then he's barely scraping the surface. In part one we start off in the decade where the sex comedy really started to take off overseas at first: the 1970s! This was especially obvious in places like Great Britain and Italy, and this trend would seemingly influence North American sex comedies to push the envelope even further later in the decade, before they totally came to dominate in the 1980s. --Up Pompeii from "Up Pompeii" (1970) --Frankie Howerd --God's Children & Lola from "Percy" (1971) --The Kinks --Au Pair Girls 2 from "Au Pair Girls" (1972) --Roger Webb --Sessomatto from "How Funny Can Sex Be" (1973) --Armando Trovajoli --Alvin Purple from "Alvin Purple" (1973) --Brian Cadd --Lovin' Is from "Alice Goodbody" (1974) --Rick Harris, Candy & Mr. D --This is Your Life Timmy Lea from "Confessions of a Window Cleaner" (1974) --Su Cheyenne --Girl from Starship Venus from "The Girl from Starship Venus" (1975) --Don Lang --Confessions of Timmy Lee from "Confessions of a Pop Performer" (1975) --Three's a Crowd --Kipper; Accidents Will Happen; Oh Sha La La & The Clapham from "Confessions of a Pop Performer" (1975) --Kipper (Dominic Bugatti & Frank Musker) --Theme from "The Ups and Downs of a Handyman" (1975) --Vic Elms (vocals by Barry Stokes) --Sq. 1 - Titoli & Seq. 3 from "The Sensuous Nurse" (1975) --Gianfranco Plenizio --My Cruisin' Casanova from "Adventures of a Taxi Driver" (1976) --Adrienne Posta --The Love Bug from "What's Up Nurse!" (1977) --Tony Burrows --Private Eye from "Adventures of a Private Eye" (1977) --Christopher Neil --The New Carioca from "The Kentucky Fried Movie" (1977) --Jonathan & Darlene Edwards --Heavy Bopper from "The Kentucky Fried Movie" (1977) --Alan Moorhouse --Give Me England from "Confessions from a Holiday Camp" (1977) --The Wurzels --It's Great to Be Here from "Come Play with Me" (1977) --Peter Jeffries (vocals by Alfie Bass & George Harrison Marks) --Come Play with Me from "Come Play With Me" (1977) --Coming Shortly (Peter Jeffries) --Chevy Van; Country Lady & Early Morning Love from "The Van" (1977) --Sammy Johns --Animal House from "Animal House" (1978) --Stephen Bishop --Lollipop from "Lemon Popsicle" (1978) --The Chordettes --Hold On, I'm Coming from "What's Up Superdoc!" (1978) --Fingers (Paul Fishman) --I'm Flying from "Adventures of a Plumbers Mate" (1978) --Christopher Neil --Love Crazy from "Carry on Emmannuelle" (1978) --Masterplan (Kenny Lynch) --Lola Langusta from "Beneath the Valley of the Ultra-Vixens" (1979) --Paul Ruhland --Van Nuys Blvd. & Mama's Car from "Van Nuys Blvd." (1979) --Ron Wright & Ken Mansfield --All of My Friends from "Gas Pump Girls" (1979) --Kirsten Baker --Theme from "Spaced Out" (1979) --Emil Zoghby --You Got Me Up There from "Spaced Out" (1979) --Tommy Hunt Opening and closing music: Summertime Killer from "Summertime Killer" by Luis Bacalov, and Santa Maria from "Raiders of Atlantis" by Oliver Onions.

On this episode of Hassell Talks, architect and urbanist Caroline Stalker joined retired Partner of Buro Happald Andrew Comer and architect, urbanist and Head of Design Ashley Munday to explore the potential mechanisms for creating a successful Olympic and Paralympic Games legacy for Brisbane and SEQ. London's approach was to look beyond 2012 - to 2057, with the hard decisions made at the very beginning resulting in transcendent change across the city. Is Brisbane brave enough to do the same?   Recorded on Jagerra and Turbal Country, Meanjin, Brisbane.  

Welcome to today's show where leading demographer Simon Kuestenmacher and I explore the potential for Olympic-driven growth in the lead-up to the 2032 Brisbane Olympic Games. As history has shown us, the Olympics can serve as a catalyst for urban development and long-lasting change, turning South East Queensland into a highly connected and liveable region. However, with Australia grappling with an approximately 20-year infrastructure backlog, the challenge of balancing this new development with the needs of a growing population is ever-present. In today's show, we'll delve into the importance of timely infrastructure development, learning from the success stories of Olympic host cities like Barcelona and Munich, and exploring the ambitious vision for SEQ as a thriving, interconnected megacity. We will also discuss the challenges that SEQ faces, and the future of this dynamic and evolving region. If you live in Queensland this information will be vital for you, and of course as a property investor it will be important to understand these things if you have any interest in investing in Brisbane, Australia's new world city. Links and Resources: Michael Yardney Get the team at Metropole to help build your personal Strategic Property Plan Click here and have a chat with us Simon Kuestenmacher - Director of The Demographics Group Shownotes plus more here: Olympic Endeavours: Seizing the Once in a Lifetime Opportunity in South East Queensland with Simon Kuestenmacher

 In this episode of the "UX Leadership by Design" podcast hosted by Mark Baldino of Fuzzy Math, Greg Thomas, Director of User Experience at TaxSlayer, shares how his team captures user data at specific times to make data-driven decisions and presents a strong case to executives, business owners, and product leaders. By using a one-question survey with a one-to-seven scale (Single Ease Question or SEQ) , they prioritize fixes in the backlog and give users a voice without adding any overhead to the team. This episode is a valuable resource for UX design leaders seeking insights into capturing customer data and making better decisions.Topics Covered:- Making data-driven decisions in UX design- Benefits of user-centered design for business success- Importance of data capture tools and user feedback in UX design- Understanding and using Single Ease Question (SEQ) Scores to improve UX design- Prioritizing fixes and challenges in UX design- Building and leading UX research teams- Driving design decisions through in-context data capture- Strategies for Prioritizing Fixes in a UX Design BacklogAbout our Guest:Greg is a software industry veteran with an extensive background in researching and creating user-centered omnichannel customer experiences and in managing, advising Product Management and helping set strategy going forward.Examples of his work can be found on a wide array of platforms including; web, mobile apps, tablet apps, mobile web, point of sale, pin pad, kiosk, voice systems, mobile payment, and internal employee operation systems.Currently, he is the Director of User Experience Design at TaxSlayer.com where he reports to the CEO and works directly with Senior leadership.  Prior to joining TaxSlayer, he worked for Fortune 500 companies such as Walgreens, Motorola and for other industry leaders such as Peapod, and Legacy.com.He holds a Master's Degree in Human-Computer Interaction from DePaul University in Chicago, a Bachelor's Degree in Marketing from Butler University, and an executive certificate in Product Management from the Haas School of Business at the University of California, Berkeley.His innovations have led to him being listed as a co-creator of one patent and sole creator of another.Resources & Links - Find Greg on LinkedIn: https://www.linkedin.com/in/gthomas10/- More about Single Ease Question  (SEQ): https://measuringu.com/seq10/#:~:text=The%20Single%20Ease%20Question%20(SEQ)%20is%20a%207%2Dpoint,was%20the%20task%20to%20complete%3FFuzzy Math: fuzzymath.com Mark on LinkedIn: https://www.linkedin.com/in/markbaldino/

Javier Di Granti presenta... LOUNGE CINEMATICA PODCAST RADIO Temporada 3 * * * Episodio 3x17 (27/04/23) Locuciónes de Xavi Martin e Iris Lago Seleccion y direccion de Javier Di Granti * * * ///Tracklist//// 01. Ennio Morricone - Doricamente //Cabecera Lounge Cinematica Temporada 3 02. Piero Umiliani - Due Ragazzi Da Marciapiede (Javier Di Granti Suite) [Quartet Records QR511 ©2023]* includes: Oh Che Bella Festa! / Seq.05 / Seq.06 / Seq.04 / Seq.09 / Latin Lover #1 / Seq.13 / Al Ballo Di Carnevale / Seq.15 / Seq.18 //Intermedio Publicitario 03. Armando Trovajoli - Oggi A Berlino (Javier Di Granti Suite) [Cam Sugar Digital ©2023]* includes: Swing a Berlino / Oggi a Berlino (Cha cha cha) / La notte a Berlino / La notte a Berlino #3 / Oggi a Berlino (Finale) *Novedad Discográfica / New Release

There was a post on Twitter from @NathanBaugh27 (https://twitter.com/nathanbaugh27/status/1642165691309604864?t=DySP_gqPyNi-egW_1f_sEQ&s=03) that shared lessons about storytelling from the masters like Gaiman, Tolkien, King, etc. It resonated with me and so I wanted to share it and add my commentary to it. So check out this episode and please share your thoughts down in the comment section or hit me up on social media @PhilSvitek. Lastly, for more free resources from your 360 creative coach, check out my website at http://philsvitek.com. RESOURCES/LINKS:  -Coach or Consultant Services: https://philsvitek.com/lets-work-together/   -Podcast Services: http://philsvitek.com/podcastservices  -Love Market Film: https://www.amazon.com/Love-Market-Amy-Cassandra-Martinez/dp/B09DFS3FTZ/ref=sr_1_14  -Patreon: https://www.patreon.com/philsvitek   -Merchandise: https://shop.spreadshirt.com/phil-svitek---360-creative-coach/   -Instagram: http://instagram.com/philsvitek   -Facebook: http://facebook.com/philippsvitek  -Twitter: http://twitter.com/philsvitek  -Financially Fit Foundation: http://financiallyfitfoundation.org  -Master Mental Fortitude Book: http://mastermentalfortitude.com  -Elan, Elan Book: http://philsvitek.com/elan-elan   -In Search of Sunrise Book: http://philsvitek.com/in-search-of-sunrise  -A Bogotá Trip Film: https://philsvitek.com/a-bogota-trip/ 

Dan gives Benji with Clever Fox Online a call after a colleague reaches out to Dan and wants to know more about which DIY Website Builder he should use until he has enough business to support paying a website and SEQ guy. Benji gives Dan a run down of some popular DIY Website Builders and a golden nugget of what you should before you even think about tacking a website!▶ Click HERE to register and see when the next FREE Stain Seal University will be near you!!▶ Click HERE to register for the Fence Show & Security Expo coming in August 2023 hosted by the FWA (Fence Workers Association)Use Promo Code MFL50 to get 3 days FREE on the Exhibitor Floor▶ Get early access to BizzRater. The only platform that allows YOU to "Take Advantage of Your Reviews"! Use PROMO code MFL30 and save 30%▶ Thank you to our sponsor

Nicholas Blumhardt is the Founder/CEO at @datalust_seq, core maintainer for #Serilog, founder of @AutofacIoC, and long-ago .NET PM at Microsoft. He resides in Brisbane, Australia.   Topics of Discussion: [2:25] Nicholas talks about what got him into structured logging. [7:09] As a consultant, what surprised Nicholas about structured logging? [7:57] Rather than just being able to easily pass the logs that he was already writing, Nicholas could think about building something that was more like a developer interface for the app. [10:07] A lot of people associate the tooling and technology with DevOps, but if you dig back into why we originally set out on that path, it was much more about the practices. [11:10] Building your systems so that they are easier to run and diagnose issues is really where it's at. [12:25] Structured logging is just one tool in the tool belt to achieve observability. [13:54] What other tools does Nicholas use to gain observability? [17:09] What is Serilog and how does it serve as an interface for structured logging? [29:51] Why is Seq useful and why should listeners give it a try?   Mentioned in this Episode: Architect Tips — New video podcast! Azure DevOps Clear Measure (Sponsor) .NET DevOps for Azure: A Developer's Guide to DevOps Architecture the Right Way, by Jeffrey Palermo — Available on Amazon! Jeffrey Palermo's YouTube Jeffrey Palermo's Twitter — Follow to stay informed about future events! Programming with Palermo programming@palermo.network Nicholas Blumhardt Twitter Autofac Website Autofac Serilog Seq Nicholas Blumhardt Website nblumhardt@nblumhardt.com

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The boys continued their Round 25 preview by breaking down...North Queensland Cowboys v Penrith PanthersNewcastle Knights v Cronulla Sharks Wests Tigers v Canberra Raiders

Southeast Queensland is a fishing hotspot at any time of year because it's a melting pot where tropical and temperate species combine to create an incredibly diverse fishery. Spring is a transitional period that offers so many opportunities that I knew I had to get Nabeel Issa back on the podcast. Nabs has helped us multiple times previously with fishing opportunities and sonar masterclasses. But this time I had him talk about his favourite fishing spots around SEQ during spring! ______________ Do you find the ALF podcast useful? Want more? Then please consider supporting the show by joining Team Doc Lures! You can become a member for less than the cost of a cup of coffee per week and get access to tools and resources designed to take your lure fishing to a whole new level. Check it out here: https://team.doclures.com ______________ For full show notes of today's episode please go to https://doclures.com/se-queensland-fishing-spots-nabeel-issa/

according to all known laws of aviation, there is no way that a bee should be able to fly. Its wings are too small to get its fat little body off the ground. The bee, of course, flies anyway. Because bees don't care what humans think is impossible.” SEQ. 75 - “INTRO TO BARRY” INT. BENSON HOUSE - DAY ANGLE ON: Sneakers on the ground. Camera PANS UP to reveal BARRY BENSON'S BEDROOM ANGLE ON: Barry's hand flipping through different sweaters in his closet. BARRY Yellow black, yellow black, yellow black, yellow black, yellow black, yellow black...oohh, black and yellow... ANGLE ON: Barry wearing the sweater he picked, looking in the mirror. BARRY (CONT'D) Yeah, let's shake it up a little. He picks the black and yellow one. He then goes to the sink, takes the top off a CONTAINER OF HONEY, and puts some honey into his hair. He squirts some in his mouth and gargles. Then he takes the lid off the bottle, and rolls some on like deodorant. CUT TO: INT. BENSON HOUSE KITCHEN - CONTINUOUS Barry's mother, JANET BENSON, yells up at Barry. JANET BENSON Barry, breakfast is ready! CUT TO: "Bee Movie" - JS REVISIONS 8/13/07 1. INT. BARRY'S ROOM - CONTINUOUS BARRY Coming! SFX: Phone RINGING. Barry's antennae vibrate as they RING like a phone. Barry's hands are wet. He looks around for a towel. BARRY (CONT'D) Hang on a second! He wipes his ands on his sweater, and pulls his antennae down to his ear and mouth. BARRY (CONT'D) Hello? His best friend, ADAM FLAYMAN, is on the other end. ADAM Barry? BARRY Adam? ADAM Can you believe this is happening? BARRY Can't believe it. I'll pick you up. Barry sticks his stinger in a sharpener. SFX: BUZZING AS HIS STINGER IS SHARPENED. He tests the sharpness with his finger. SFX: Bing. BARRY (CONT'D) Looking sharp. ANGLE ON: Barry hovering down the hall, sliding down the staircase bannister. Barry's mother, JANET BENSON, is in the kitchen. JANET BENSON Barry, why don't you use the stairs? Your father paid good money for those. "Bee Movie" - JS REVISIONS 8/13/07 2. BARRY Sorry, I'm excited. Barry's father, MARTIN BENSON, ENTERS. He's reading a NEWSPAPER with the HEADLINE, “Queen gives birth to thousandtuplets: Resting Comfortably.” MARTIN BENSON Here's the graduate. We're very proud of you, Son. And a perfect report card, all B's. JANET BENSON (mushing Barry's hair) Very proud. BARRY Ma! I've got a thing going here. Barry re-adjusts his hair, starts to leave. JANET BENSON You've got some lint on your fuzz. She picks it off. BARRY Ow, that's me! MARTIN BENSON Wave to us. We'll be in row 118,000. Barry zips off. BARRY Bye! JANET BENSON Barry, I told you, stop flying in the house! CUT TO: SEQ. 750 - DRIVING TO GRADUATION --- This episode is sponsored by · Anchor: The easiest way to make a podcast. https://anchor.fm/app Support this podcast: https://anchor.fm/wearing-socks/support

Condo Owner Associations manage the daily operations of the condominium development. They are responsible for maintaining common elements such as lobbies, hallways, elevators, and outdoor spaces. Read the full article here: https://www.oflaherty-law.com/learn-about-law/illinois-condominium-property-act O'Flaherty Law now serves over 105 counties across Illinois, Iowa, and Indiana. If you have any questions regarding a case or would like to speak to one of our attorneys after watching a #LearnAboutLaw video, give us a call at (630) 324-6666 or send us an email at info@oflaherty-law.com to get in contact with someone from our team. Subscribe to our channel for daily videos dedicated to all things law and leave a comment with any questions about this topic. Find us online for more legal content and to stay connected with our team - Website: https://www.oflaherty-law.com/ - LinkedIn: https://www.linkedin.com/company/oflahertylaw - Instagram: https://www.instagram.com/oflahertylaw - Facebook: https://www.facebook.com/oflahertylawGroup/ **None of the content in this series is intended as paid legal advice. This article will provide an overview of the #Illinois #Condominium #Property Act, 765 ILCS 605 et. Seq. This article will also discuss common problems that arise under the Illinois Condominium Property Act (#“ICPA”). ‍

My circle of competence is just QAV ; Election result, investing implications ; SEQ and the “second buy line” ; outperformance by founder-led companies ; NHC's big drop ; YAL halt ; Murph from ABC died ; Howard Marks' latest memo on investor psychology ; Sri Lanka defaulting on $18bn of bonds. ; Underemployment rate now at 6.1% ; NUF has new results and crashed ; Australians lost $10Bn in crypto last year ; small stocks and Rule 1 ; what do you do in a market like this when you have a full portfolio and more capital ; a strong correlation between dividend yield and the QAV buy list ; Analysis of price to consensus target figures ; ME close v Price Chg 1mth (%) for calculating Josephine ; when a stock has done exceptionally well (say doubled) would TK use the proceeds to purchase two stocks? 

Why is hibernation something that bears and squirrels do, but humans don't? Even more interesting, what's going on inside a hibernating animal, on a physiological and genetic level, that allows them to survive the winter in a near-comatose state without freezing to death and without ingesting any food or water? And what can we learn about that process that might inform human medicine?Those are the big questions being investigated right now by a four-year-old startup in California called Fauna Bio. And Harry's guests today are two of Fauna Bio's three founding scientists: Ashley Zehnder and Linda Goodman. They explain how they got interested in hibernation as a possible model for how humans could protect themselves from disease, and how progress in comparative genomics over the last few years has made it possible to start to answer that question at the level of gene and protein interactions. The work is shedding light on a previously neglected area of animal behavior that could yield new insights for treating everything from neurodegenerative diseases to cancer.Please rate and review The Harry Glorikian Show on Apple Podcasts! Here's how to do that from an iPhone, iPad, or iPod touch:1. Open the Podcasts app on your iPhone, iPad, or Mac. 2. Navigate to The Harry Glorikian Show podcast. You can find it by searching for it or selecting it from your library. Just note that you'll have to go to the series page which shows all the episodes, not just the page for a single episode.3. Scroll down to find the subhead titled "Ratings & Reviews."4. Under one of the highlighted reviews, select "Write a Review."5. Next, select a star rating at the top — you have the option of choosing between one and five stars. 6. Using the text box at the top, write a title for your review. Then, in the lower text box, write your review. Your review can be up to 300 words long.7. Once you've finished, select "Send" or "Save" in the top-right corner. 8. If you've never left a podcast review before, enter a nickname. Your nickname will be displayed next to any reviews you leave from here on out. 9. After selecting a nickname, tap OK. Your review may not be immediately visible.That's it! Thanks so much.TranscriptHarry Glorikian: Hello. I'm Harry Glorikian, and this is The Harry Glorikian Show, where we explore how technology is changing everything we know about healthcare.It's April and spring is well underway, even though it's been a pretty cold one so far here in New England.It's the kind of weather that makes you want to pull the covers over your head in the morning and just sleep in. Or maybe just hibernate like a bear until summer is really here.But when you think about it, what is hibernation? Why is it something that bears and squirrels do, but humans don't?Even more interesting, what's going on inside a hibernating animal, physiologically, that allows them to survive all winter without freezing to death and without ingesting any food or water?And what can we learn about that process that might inform human medicine?Those are the big questions being investigated right now by a four-year-old startup in California called Fauna BioAnd my guests today are two of Fauna Bio's three founding scientists: Ashley Zehnder and Linda Goodman. I asked them to explain how they got interested in hibernation as a possible model for how humans could protect themselves from disease.…And how progress in comparative genomics over the last few years has made it possible to start to answer that question at the level of gene and protein interactions.We've always looked to the natural world, especially the world of plants, for insights into biochemistry that could inspire new drugs. But what's exciting to me about Fauna Bio is that they're shining a light on a previously neglected area of animal behavior that could yield new insights for treating everything from neurodegenerative diseases to cancer.So, here's my conversation with Ashley Zehnder and Linda Goodman.Harry Glorikian: Ashley. Linda, welcome to the show.Ashley Zehnder: Thanks, Harry, we're excited to be here today. It's going to be fun.Linda Goodman: Yeah, thanks for having us.Harry Glorikian: Yeah, I mean, well, you guys are someplace sunny and warm, and I'm actually I shouldn't say that it's actually sunny right now on the East Coast. So I'm not I'm not.Linda Goodman: Don't jinx yourself.Harry Glorikian: But the temperature is going to drop. Like to I think they said 18. So everything will freeze tonight for sure. So it'll, you know, it's one of those days, but. I want to jump right into this because we've got a lot of ground to cover. Like there's so many questions that I have after sort of looking into the company and sort of digging in and, you know, but even before we jump into what you're working on. Right, I really want to talk about hibernation. Maybe because I'm jealous and I'd like to be able to hibernate. I have sleep apnea. So sleep is a problem. But humans don't hibernate. But there's a ton of other mammalian species that that do. And sometimes I do feel, though, that my teenager hibernates, but that's a different issue. So, but, what what is interesting to you about hibernation from a physiological point of view. What what goes on with metabolism or gene expression during hibernation, that's that's not found in humans, but that could be relevant to human health?Ashley Zehnder: Yeah, I think this is a great question, Harry, because I think both Linda and I came to fauna from different backgrounds. I came from veterinary science, Linda from comparative genomics. We can go into our details later, but neither of us really appreciated the amazing physiology of these species. There are some of the most extreme mammals on the planet, and there are hibernating bears and literally every group of mammals. Right. This is something Linda specializes in. But there are primates in Madagascar that hibernate very similar to the 39 ground squirrels that we tend to work with. So it's this really deeply conserved trait in mammals, including primates. And, you know, it kind of highlights for us what our genes can do when they're adapted for extreme environments. And so that's kind of the lens that we take when we look at hibernation. It's how do these species protect their own tissues from being nearly frozen for six, seven months out of the year, having to protect their brains, their hearts, all their vital organs? They're not eating, they're not drinking. They're not moving for these really deep bodied hibernaters. When you think of 100 kilogram animal that's not eating for seven months, how do they survive that? Right. And it has to do with metabolic rates that change 200- to 300-fold over the course of a couple of hours. It has to do with oxygenation changes and protection from oxidative stress and ischemia reperfusion. And so if you look at a tissue by tissue level, you can start to see how these animals are finally adapted to protecting themselves from from damage. And then we can start to say, well, this is similar damage to what we see in human diseases. And that's why this is such an interesting system, because it's so dynamic and because it happens across so many groups of mammals, it really lends itself to this comparative genomics approach that we take to drug discovery.Harry Glorikian: Yeah. Because I was wondering sort of like what ways of healing from different sort of traumas and conditions do hibernating animals have that that humans don't, that we sort of maybe wish we did? It's sort of like, you know, almost Marvel or one of those things where you like go to sleep, you wake up, you've totally healed again, which kind of be kind of be cool. Yeah. So, you know. But when did scientists first begin to think about whether having a better understanding of hibernation might help us solve? Some of these riddles that we have in human health. I mean, it surely it can't be like a new concept. It has to go further back. I mean, what has changed recently to make it more actionable? I mean, is it, you know, omics, costs coming down that are making it easier, computational capabilities that are, you know, making all these come together? I mean, those. What do you guys. What's. What's the answer? You guys know the answer better than I do.Ashley Zehnder: I'll comment on a little bit on the physiology, and I will let Linda talk about the data revolution, because that's that's really what she knows very intimately. So from a physiology standpoint, these are species and not just hibernaters, but a lot of other species that we've been studying since the early 1900s, 1950s. I mean, these are some of our earliest biological experiments and our earliest understandings of biology. We're not necessarily done by studying humans. A lot of that was done by studying natural disease models, right? How did we figure out that genes cause cancer? So it's a little bit of a tangent, but bear with me, it was not by studying human cancer, it was by studying Rous Sarcoma Virus and how that virus picked up bird genes and then turn them on. Right and other in other individuals. So but then kind of this almost the same year in 1976 that we figured out that genes cause cancer by studying chickens. 1974 we figured out how to genetically modified mice. And we sort of figured out that like, okay, maybe we don't need to study natural biology anymore. And so I feel like we sort of lost a lot of those skills and figured out we had humans and we had model organisms and we were done. And I think now we're kind of in this renaissance where people are realizing that actually there's still a lot of natural biology that we can learn from. But it's being powered now by this data revolution and the decrease in cost and sequencing and availability of omics data like RNA. Seq and then I will pitch that over to Linda because that's really what she knows best.Linda Goodman: Yeah, yes, absolutely. You know, Ashley's right. And I think just to add on to that, that there was this issue in which there were a lot of field biologists out there working with these really fascinating hibernating animals. They knew a lot about what these animals could do, the extreme environments they were exposed to, that they could overcome, they could protect all of their tissues. And there was so there was a group of field biologists who knew all that information. And then on the other side, you have all of these geneticists who are studying the genomes of probably humans and mouse and rat. And they weren't really talking to each other for a long time. And I've been in the genomics field for at least a decade, and not until very recently did I even hear about all these amazing adaptations that these hibernating mammals have. So I think some of it was just a big communication gap. And now that the genomics field is starting to become a little more aware that all these exciting adaptations are out there that we can learn from, I think that's going to be huge. And yes, of course, it certainly does not hurt that there's been a dramatic drop in sequencing costs. We can now sequence a reference genome for around $10,000. That was unheard of years ago. And so a lot of these species that people would previously consider untouchables because they were not model organisms with a pristine reference genome, we can now start to approach these and thoroughly study their biology and genomics in a way that was not possible several years ago.Harry Glorikian: Yeah. I was thinking I was, you know, I was laughing when you said $10,000, because I remember when we did the genome at Applied Biosystems and it was not $10,000.Ashley Zehnder: Yeah.Harry Glorikian: Yeah. And it took I remember Celera, we had an entire floor of sequencers working 24/7 I mean, it was an amazing sight. And now we can do all that, you know, on a.Ashley Zehnder: Benchtop. Benchtop. Exactly. On a benchtop.Harry Glorikian: So. But, you know, it's interesting, like in a way, studying animals to learn more about disease mechanisms seems like a no brainer. I mean, we share a, what, about 99% of our DNA with chimpanzees. And for those listening. Yes, we do. You know, I'm sure there's people out there that, like, bristle when I say that. But what is it, 97.5% of our DNA with rats and mice. That's why we use all these things for sort of safety and effectiveness of drugs meant for humans. But. Still, I'm not used to drug hunters starting out by looking at animals, you know? Why do you think it's taken the drug industry, although I'm I say that very loosely, [so long] to wake up to that idea?Ashley Zehnder: Yeah. I think it's I think it's again, this almost reversal of the paradigm that exists today, which is let's take a human disease that we want to make a new drug for. Let's take a mouse and let's try to genetically manipulate that mouse to mimic as closely as possible what we see in the human disease. And those are always imperfect. I mean, I did a cancer biology PhD at Stanford, and there's that trope of like, Oh, if I had a dollar for every time you occurred mouse in a human right, it would need to work anymore. That's replicated across many fields, right? They're not good models. And so we're saying like obviously that doesn't really work for discovery. It's fine for preclinical and safety and you have to use those models. But for pure discovery, that's not where you want to be, right? Instead, you want to take the approach of saying, where has nature created a path for you? Where is it already solved this problem? And I think there are companies like Varian Bio who are doing this in human populations. We're saying, let's look at humans that have unique physiologies and a unique disease adaptations. And of course then you have to find those niche pockets of human populations.Ashley Zehnder: So that's not a not a simple problem either. But the approach is very analogous. What we're saying is we can use that rare disease discovery approach and just expand that scope of discovery. Look at highly conserved genes, look at how other species are using them to reverse how phosphorylation in the brain to repair their hearts after damage, to reverse insulin dependence. To heal, we'll heal their tissues or regenerate stem cells. Let's just see how nature did it right and just mimic that instead of trying to fix something that we artificially created. So it's literally reversing that paradigm of how we think about animals and drug discovery. But you have to know how to do that. You have to know which models are correct. You have to know how to analyze 415 genomes together in an alignment which is really complicated. Linda knows how to do that, so you have to know how to do it correctly, although you could screw it up very badly. So there's a lot of expertise that goes into these analyses and also again, the data availability, which wasn't there nearly a decade ago. So.Harry Glorikian: So I asked this question out of pure naivete, because I'm not sure that I could sort of draw a straight line. But, you know, which drugs were have been discovered through research on genetic mechanisms of disease in animals. Is there, are there?Ashley Zehnder: You know, I think directly it's a new field. Right. So I think, Linda, you and I have looked at some examples of looking at drugs for narcolepsy, looking at dog genetics and studies, looking at muscle disorders in certain species of cattle that have naturally beefed up muscles and translating those into therapies. I mean, there are examples of looking at animals for things like genotype, right, came from Gila monster venom, although that's not strictly a genetic program. Right? So I think this idea of looking at natural animal models is a source of innovation. It's just that, again, the data wasn't really available until fairly recently, but we know the strategy works by what's been done on things like PCSK9 inhibitors in humans, right? It's a very similar approach to that. It's just expanding that scope of discovery.Harry Glorikian: So because you guys raised money and you guys are moving this forward, sort of and I don't want you to tell me anything that's confidential, but. So what was the pitch when you when you put that in front of everybody?Ashley Zehnder: It was really that, look, drug discovery right now is really been hampered by a lack of innovation. And we're really stuck in looking at these very kind of currently limited data sources, which is humans and again, these handful of really imperfect animal models. But we can take what we've learned from working with human genomics and really greatly expand the opportunities for a number of diseases that still don't have good therapies. Right. We've had the human genome for really close to 20 years now. We spent a lot of money sequencing it. And still, if you go back and look at the FDA approvals in the last two years, which I did by hand a while ago, or more than three quarters of those are not new targets. They're new drugs for a new indication or new drugs, same drugs before a new indication or they're kind of meta pathway drugs or they're drugs for which we still don't know the mechanism. It's some small molecule. It's been around since fifties. And so like where is the innovation in the top ten diseases of people still have it changed? So like where I pulled these two headlines right not too long ago, one from 2003, which is like the era of the genomics revolution. Right? And then one from 2019, which was the genomics revolution question mark. Right. Like we're still sort of waiting for it. And so what is that missing piece of data that's really going to allow us to really leverage the power that's in the human genome? And to do that, we have to put our own genes in an evolutionary context to understand what's important. That's been that third dimension of genomics that's been missing. So it's really not necessarily about any particular species that we work on, all of which are amazing. It's really about using that data to shine a better light on what's important in our own genome. And so that's a lot of the pitches, like how are we going to use our own genome better and find better treatments?Harry Glorikian: Yep. Understood. So. You have a third founder, Katie Grabek. Right. So. Tell me about yourselves. I mean, did the three of you get interested in comparative genomics and hibernation? How did you come together? How did you decide like, oh, hey, let's do a startup and get this thing going in this area? So tell tell me the origin story.Ashley Zehnder: Linda, do you want to kick off?Linda Goodman: Sure. I think it all really started, Ashley and I initially started batting a few ideas around. We both had this understanding that that drug discovery today did not look outside of human mouse rat very much. And we both understood there was this wealth of animal data that's just waiting to be used and no one was doing it and we couldn't really figure out why. And we were having trouble figuring out exactly which animal we wanted to study and which diseases we wanted to study. And it just so happened that we lucked out. There was another woman in our lab at Stanford, Grabek, who had the perfect study system for what we were thinking about. She had these amazing hibernates our animals that have exquisite abilities in terms of disease, resistance and repair. And once she started talking about all the amazing phenotypes these animals have, we thought, wow, that would make a great study system to make the next human therapeutic. Yeah. And I think it's interesting that both Katie and Linda have human genetics PhDs. Right. So I think both of them and Linda can expound on this. But from Katie perspective. Right, she she went in to do a human genetics Ph.D. trying to understand how genes can be used to improve human health and shouldn't be rotating the lab of somebody who studied the 39 ground squirrel and said this physiology is way more extreme than anything we see in humans, but they're doing it using the same genes.Linda Goodman: What are those genes doing in these animals that we can adapt for human therapeutics? And so she brought that work with her to Stanford and was really one of the preeminent researchers studying the genetics and genomics of these species. My background is I'm of Marion, so my clinical training is in exotic species. So as a clinician, I treated birds, mammals, reptiles and saw that they all presented with different kinds of diseases or in some cases didn't present with diseases like cancer that were super interesting. And then coming to a place like Stanford to do a PhD, it was working with a bunch of human researchers, human focused researchers. They're all generally human researchers, but you know what I mean? It's a little bit tricky with the nomenclature. Generally, I have my doubts about, you know, maybe there's some chimpanzees doing research somewhere, people studying human diseases, right from a human lens who are completely ignorant of the fact that animals often also had these disease traits or in some cases were resistant to them. So there was this huge disconnect there of of biologists and veterinarians and physiologists who understood all these traits across different species and the people who knew the molecular mechanisms, even though a lot of those are shared.Linda Goodman: And so one of the things that I found really interesting just from a cancer perspective was that a lot of our major oncogenes are highly conserved because these are core biological genes that if you screw them up, will give you cancer. But there's an evolutionary pressure to maintain these genes. And so there's a reason why they're conservative, because they're really important biologically, and that's true across many other diseases as well. So from that perspective, I was really interested in this intersection of human and animal health. I always wanted to do more genomics myself and just never had had the training. Linda had always been interested in veterinary science, and so we kind of immediately started collaborating and saying, Look, look, there's a huge opportunity in this, again, third space, third dimension of genomics that people are not looking at. What do we do trying to start a comparative genomics company? I'm using air quotes here for the podcast listeners is a little bit broad. Where do you start? And I think Katie really gave us that start in saying, here's a model. We have a biobank of samples that are proprietary to fauna. We have an expert in this field. We have a model that's good for so many different diseases. Let's prove that the process works here and then we can expand into multiple disease areas.Harry Glorikian: You know, you got to love, people I think, underestimate that magic that happens when the right people get together and the spark happens, right? I mean, I'll take that. Any day. I mean, I love coming up with a plan and then, you know, working to the plan. But when it happens, when the right people in the room and they're all get excited, those are those are the most incredible start ups, in my opinion. Yeah. So you're starting off with targets in heart disease, stroke, Alzheimer's, diabetes, very different areas, right? Cardiovascular, neurodegenerative and metabolic. So. Why start with those areas in particular?Linda Goodman: So I think for us it was really again showing showing what we can translate from this model. So some of the phenotypes that we see, the traits that we see in the ground squirrel, which is predominantly one of the species we use for our work, is that they're exquisitely resistant to ischemia, reperfusion injury. So the kind of injury that gets, if you have a heart attack and you go and get the heart attack on block, you get this rush of warm, oxygenated blood back into your heart that can actually be damaging. And that's a lot of what causes damage after a heart attack, what these animals happen, they do this 25 times over the course of a 6 to 7 month hibernation cycle. And if you look at their hearts in the peak of one of these periods, there is an upregulation of collagen, which is cause of fibrosis. There's an upregulation, there's histologically, there's a little bit of damage. It's less than you would I would have, but there's a little bit there. But if you get to the end of that whole cycle and look at their hearts, they look normal and they do it again next year. Right. So you and I could not survive 25 of these attacks over six or seven month period, right? Obviously not. So let's pick the strongest phenotypes we have in these animals and let's show that we can use information from that and come up with genes and compounds that are protective in our more standard models of these diseases.Linda Goodman: And that's what we did really with the first round of data that we had is we generated four genetic targets and two compounds that came out of the heart data that we had from hibernating and that we tested them in human cardiomyocytes in a dish and said if we take oxygen and glucose away from these cells, they get really unhappy and die and we could double survival of human heart cells in a dish. And then we said, okay, great, let's actually move this into animals. And so we used AAV or some of these viral vectors to then knock down genes in vivo in hearts of rats. So we literally tied off a coronary artery and then let the blood come back in and saw that we could almost fully protect these hearts from damage by knocking down genes that we found in the hibernating data. So it was really closing that loop and saying, where are the strongest traits? Can we show that this works? And then it was really figuring out where are the really large areas of unmet need. And so in terms of metabolism, we end up connecting with Novo Nordisk, which is a publicly disclosed partnership. They are very focused on obesity. We have a model that increases this metabolism, 235 fold over an hour. Name another model that can do that, right?Harry Glorikian: I need that. I need that. I need like, because...Ashley Zehnder: We all need that!Harry Glorikian: I could get rid of a few pounds right around here.Linda Goodman: Exactly. So then it's really just figuring out where are the unmet needs, who is really interested in these areas we're looking at and do we have unique data that speaks to those models? And that's really we just try to be guided by the biology and saying, where do we have unique data sets that can answer high unmet needs?Harry Glorikian: Okay. Well, all I mean, all sounds super exciting if we can make the translation, you know, in the right way and find those targets. But. You guys have built up a significant biobank, right? I understand you have a huge database of genomic readout from various hibernating animals. Can you tell us a little more about the extent of that biobank? How did you collect the data and how unique is that database in the industry?Ashley Zehnder: Yeah. Linda, do you want to talk a little bit about the data sources that we're currently using at Fauna?Linda Goodman: Yeah. So maybe, you might be the best person to talk about the Biobank and then I can talk about all the other data sources layering on top of that.Ashley Zehnder: Yeah, I'll talk a little about the BiobanK. So we have yeah, we have a number of different data sources. The Biobank is one of them and probably one of the main ones that we use. So Katie, during her PhD, built a really unique biobank of very precisely time tissue samples from 39 ground squirrels across the whole hibernation cycle. And the reason why that timing is so important is because the cycle is so dynamic. If you don't have really precise sample timing, you end up with a big kind of smush of data that you can't tease apart by having really precisely timed data points, you can separate these genes into clusters and know exactly kind of where you are in time. And that timing relates to the physiological injuries that we study. So we know what time points their hearts are protected because those physiological studies have been done. We've looked at those time points very specifically. So we have that biobank of samples that we in licensed as founding IP at Fauna CANI literally drove it across the country in a U-Haul because we didn't trust anybody to move it. So that's that's now in our freezers and Emeryville with a cadre of backup batteries to protect it.Ashley Zehnder: So that's the founding data that we have. And that's been really crucial because I look at other companies trying to use data for drug discovery, particularly in the early stage. A lot of it is kind of publicly available data or cell lines or kind of shared data sources. And part of what is unique about font, as we literally have truly novel data sources that we're starting with that are wholly owned that we control and we know the quality of those. So that's really the Biobank that we have is and it's 22 different tissues. I mean, it's brain, it's kidney, it's lung, it's hard. It's liver or skeletal muscle. Right? Pretty much every kind of tissue you would want in that founding biobank. But then on top of that, I think what we've done with the other data is super important. Yeah. And so we layer on top of that all sorts of publicly available data and also data we've been able to source, such as human data from the UK Biobank. But I really want to hit on the point of, of why the model species hibernate or data is so different. All of the other data that most people work with is trying to compare animals that are healthy to animals that are diseased, or people that are healthy to people who are have disease. What's really unique about the model species that we're working with is we're trying to figure out why they have these superpowers in terms of disease, resistance and repair.Ashley Zehnder: So it's kind of the other end of the spectrum that we're making this comparison between a normal, normal hibernate or during, say, the summer months and then a hibernate or that has gene expression patterns that mean that it's resistant to many diseases and it can repair tissues when it gets damaged. So it's actually quite different from the normal types of comparisons that others would make. But yes, and then we integrate publicly available data from sources like Open Targets Reactance. And one of the other data sets that we work with that's that's valuable is that we go back through literature that is relevant to the disease, indications that we're going after. And we have a team of curators that mines these papers that where the biology is relevant and we integrate those transcriptomic studies generally into our database. And that that really helps with our comparisons. And I can kind of give you an example of the way that we would do this type of cross-species analysis compared to what other what others in the industry might do if they were just looking at humans or say, just looking at mouse and rat is that, you know, if you're if you're just looking at at a human study and you're trying to say, look, for what genes do we think are involved in heart failure? You would look at, say, transcriptomic, differences between healthy human hearts and failing human hearts.Ashley Zehnder: And then you would have some type of gene list where you'd see the genes that have differential regulation between those two groups. And it fa not we we look at that type of data and then we also look at hibernate or data and then we can compare that. And that's really where the magic happens because we can look at hibernate hours when their hearts are protected during the winter months. So we have an example of these are genes that are involved in protection and then compare that to the summer months where they're not protected. And then we can integrate both of those to analyses so we can say what's really different about a human heart when it is failing to a hibernating heart when it is protected. And we do very fancy types of network analyses and then we layer on all of these data from external sources and the really exciting moments where we see these networks light up with the exact regulation patterns we are expecting that is relevant to our biology. Those are really fun. And I would say the other data source, Linda, that would be good to touch on is the genomic data, right? I think the comparative genomics data. So maybe give a little context on that. I think that really broadens the the views point of what we work with.Linda Goodman: Yeah, absolutely. So that's another data source that we work with. We have a collaboration with the Broad Institute that is one of the leaders of the Zoonomia Project that has in the neighborhood of 250 mammals in a in a big alignment. So we can do comparative genomics across all of these animals. And what we like to look for are comparing the genomes of animals that have a specific phenotype to others that don't. So for example, what is different in the genomes of hibernaters compared to the mammals that cannot hibernate? And we typically do this with how fast or slow evolving genes are, right? So if a gene doesn't accumulate very many mutations in hibernate hours, then it's probably pretty important for hibernation because there's a lot of purifying selection on that versus say, in other mammals that are not hibernaters, like like a human or a rat. It got a lot of mutations in it because it didn't matter as much for those animals. So that's another way of pinpointing the genes that are really important to hibernation. And we know, of course, that some of those might relate to the overall hibernation trait, but many of them are going to be disease relevant because they've had to evolve these genes in a way to protect their hearts and their other organs from these extreme environments they're in during hibernation.Harry Glorikian: So that, if I'm not mistaken, so did the Zoonomia Consortium, there was a big white paper about comparative genomics published in Nature.Ashley Zehnder: Nature last year? Yep. Two years ago. Yeah. A little bit.Harry Glorikian: Yes. Time seems to blur under COVID.Ashley Zehnder: Yeah.Harry Glorikian: How long have I been in this room? Wait. No.Harry Glorikian: But. Can you guys I mean, because doing comparative genomics is not, you know. It's not new necessarily, but can you guys summarize sort of the. Arguments or the principles of that paper, you know, quickly. And then, you know, my next question is going to be like, do you feel that Fauna Bio is part of a larger movement in science and drug discovery that sort of gaining momentum? So I'll, I'll I'll let you guys riff on that launch.Ashley Zehnder: Linda, you're you're the best one to do a perspective on that paper for sure.Linda Goodman: Sure. Yeah. You know, I think this is really born out of the concept that in order to identify the most important genes in the human genome, we need to be looking at other animals and more precisely, other mammals to see their pattern of evolution. Because if you see a gene that looks nearly identical across all other mammals, that means that it's really important. It means that it has been evolving for somewhere in the neighborhood of 100 million years, not accumulating mutations, which really translates to if you got damaging mutations in that gene, you were a dead mammal. Those have been selected out. And that's really how you can tell these are the key genes that are important to to your physiology, the difference between life and death. And you can't understand those things as well by just looking within humans and human populations. We're all too similar to each other. But it's really when you get to these long time scales that the statistics work out where you can see, okay, this has been this mutation has not happened in 100 million years. We don't see it in anybody's genome. So that is obviously very important. And that's just this other way of looking at our own human genome that helps highlight the genes that are going to be important to diseases. And I think, you know, another side to this paper related to conservation and the fact that a lot of these animals with really exciting genomes, the ones that are exciting to people like us, are those that have these really long branch lengths where they're they're kind of an ancient lineage. And that's really where the gold is, because that helps us even more understand how quickly or slowly some of these genes are evolving, and it related to trying to conserve some of these species as well.[musical interlude]Harry Glorikian: Let's pause the conversation for a minute to talk about one small but important thing you can do, to help keep the podcast going. And that's leave a rating and a review for the show on Apple Podcasts.All you have to do is open the Apple Podcasts app on your smartphone, search for The Harry Glorikian Show, and scroll down to the Ratings & Reviews section. Tap the stars to rate the show, and then tap the link that says Write a Review to leave your comments. It'll only take a minute, but you'll be doing a lot to help other listeners discover the show.And one more thing. If you like the interviews we do here on the show I know you'll like my new book, The Future You: How Artificial Intelligence Can Help You Get Healthier, Stress Less, and Live Longer.It's a friendly and accessible tour of all the ways today's information technologies are helping us diagnose diseases faster, treat them more precisely, and create personalized diet and exercise programs to prevent them in the first place.The book is now available in print and ebook formats. Just go to Amazon or Barnes & Noble and search for The Future You by Harry Glorikian.And now, back to the show.[musical interlude]Harry Glorikian: I should say congratulations because you guys did raise a $9 million seed round last fall from a group of venture funds, some in life sciences, some more general. Right. What does that funding do? What is it? What does that unlock next?Ashley Zehnder: You. I will answer that question. I do want to jump back to your other question that was kind of is this part of a larger movement and comparative genomics? Right. I think that's an important question. I think you sort of hit the nail on the head there. We were invited to a symposium in August of 2019 called Perspective and Comparative Genomics that was held at NHGRI in Bethesda. And I think there's a recognition and actually some of our grant funding is also through NHGRI. And I think there's a recognition from the folks who sequenced the human genome, that they don't have all those answers. And so it's an interesting time where we realize that there is this kind of other data out there that can help us really understand that better. And it does feel a little bit like a rising tide. And so that's that's something that I think is important to recognize. But in terms of the seed round, really, that was meant to expand the platform and the pipeline that we built with our initial funding back from Laura Deming and Age One and True Ventures, who led around for us in early 2019. It's really saying like that initial $3 million or so is really to say like, does this work or is this crazy, right? Can we it's just a crazy idea.Ashley Zehnder: And that's what we really started to generate those first few animal studies that said, yes, actually we can find genes and compounds from this data that meaningfully affect not only human cells, but animal models of human disease. And now we're really expanding into new disease areas. We're looking at areas like fibrosis. We're looking at areas like pulmonary disease. We've got some really interesting data coming out of animal models of pulmonary hypertension with a compound that we found on our platform. We've got the collaboration with Novo Nordisk, which of the five genes that they tested in animals? We have one that has a significant obesity phenotype. So I mean, 20% hit rate on a novel target discovery in vivo is not bad, right? So we've gotten to the point now where repeatedly over multiple disease areas, we've seen that between 20 and 30% of our either compounds or genes are hits, which shows us that this is not only kind of a we got lucky in cardiac disease, but actually this is a process for enriching for important drug targets. And now it's a matter of really expanding the pipeline. We brought on a really experienced head of Therapeutics Discovery, Brian Burke, who spent 20 years at NIBR running very early discovery programs and then seeing programs go into the clinic.Ashley Zehnder: He worked on drugs like Entresto and then worked on a couple of startups after that. So he's kind of gotten both big pharma and startup experience, and his job at Fauna is to really look at the menu of things that we're presenting him from an early research and discovery phase and picking the winners and really figuring out how to take them forward and also killing the programs that are less exciting to him for a number of technical or practical reasons. So that's been really, really helpful to have someone come in truly from the outside and take a look at the science at Fauna and say this is as good or better as anything that I've worked on before. I'm really excited to work on this, and that's been kind of a nice external perspective on on the science and the pipeline at Fauna. So that's really what the $9 million is for. It's really expanding a lot of the computational expertise and and progress and Linda can talk a little bit about that, but also just expanding into new disease areas as well.Harry Glorikian: Understood. So, you know, on this show, like, I talk a lot about, you know, technology, data, and how it's all affecting health care, which this all fits into. But one of the things we talk about a lot is how crappy, terrible, I should use, you know, terrible, right, electronic health records are in the lack of interoperability between them. And Ashley, you actually wrote a paper.Ashley Zehnder: I did, yeah, veterinary medical records are just as bad, actually, veterinary medical records are probably a little bit worse, if it's possible.Harry Glorikian: And to be quite honest, I'm sorry, I just hadn't thought about Fifi or Rover and their...Ashley Zehnder: Their medical records.Harry Glorikian: EHR. Is like is the problem bigger, even, when it comes to functional genomics? I'm trying to think of like obtaining and storing and analyzing 'omics of different species. I mean, who's working on this? Is that part of the Zoonomia consortium? Right. I'm just trying to think it through, like, how do you get all this information and then look at it across all these different species. And at some point, you know, look looking at it against humans also.Ashley Zehnder: Yeah. I'll let Linda talk about the genomics side. I'll comment on sort of some of the validation, some of the externally curated data that Linda talked about. I think this is actually becoming a really important data set. It was a little bit of a slow burn to figure out how to get it and to curate it. But there are a lot of studies now coming out and not just your traditional model organisms, but naked mole rats and long lived rock fishes and primate studies and bats and all kinds of people looking at genomics and RNA seek metabolomics and proteomics across these species that have interesting phenotypes. The problem is, every one of those researchers really heads down on their own species of interest, right? Nobody's saying, oh, well, actually, we're seeing the same genetic signature in these bats that we're seeing in the naked mole rats that we're seeing in some of these long lived fish. Right. But that data is not in a very friendly format. So we were like originally we were like, okay, we're going to write some scripts, we're going to try to pull some of the stuff out of supplemental tables. It's going to be awesome. No, no, no. We have very highly trained curators who work on this data and bring it in. And we have a very standard pipeline and a process and a way to normalize the data across different studies and standard ontologies and ways to clean up this data in a way that it can be integrated with the genomics coming out of the platform. And that is a tedious and painful and ongoing effort to bring in all this data.Ashley Zehnder: Now, we have data from well over 330 individual studies, over 30 species. I think Linda, you told me it was like more than 800,000 gene entries at this point that's curated and that's kind of growing month over month. So now that's becoming part of our defensible moat, is that we've taken the last two or three years, again, slow burn, pulling all this data together in a way that it can be reused. And now we can turn a paper around and put it on a platform in a week or two. So we're kind of always scanning for these studies. But yeah, it's, it's, it's out there, but it's not always in a usable format without a lot of pain and effort. And so we've kind of put that pain and effort into getting that data in a place that we can use it. And then, of course, the comparative genomics is like a whole 'nother level of complexity.Linda Goodman: Yeah, so I can talk a little bit about how we do that within the comparative genomics community and how we've done that for Zoonomia. Because I referenced before that we like to do these sorts of studies to examine the genomes of hibernate ers and non hibernate and figure out what's different. And you'd think it would be a trivial question who is a hybrid nature amongst mammals? But it's actually not. And so along with our collaborators Alison Hindle and Cornelia Santer, as part of the Genome Project, Fauna tried to go through and categorize every every genome that was in Zoonomia. So we're talking about around 250 mammals for is it a hibernater, or is it not? And you'd be surprised how often it was digging through literature from the 1970s and someone would say, this animal is not often seen during the winter. So we think it hibernates and it's not always the most satisfying. And so it is an extremely tedious effort, but well worthwhile to go through and say this animal, I'm very sure, hibernates. This one, I'm very sure does not. And then there's this third category of animals that were unsure about we're going to remove those. And it's tedious, but you have to do that part, right? Because if you do the analysis with bad data, you're never going to find the genes that you want. And Linda, I remember you telling me when you were going through this very painful process, I think your threshold for being a perpetrator, quote unquote, was that you could drop your metabolism like 50%. Correct me if I'm wrong, and humans could go down to like 40 like in certain instances, like humans are almost there. You know, it's it's hard to know when there is only one paper about it, but certainly there are some really deep meditative states and humans and low oxygen environments where, you know, we're getting kind of close to the area where we might say that that's a hibernated, but certainly not the duration that you get out of hibernation. But it's it's it surprised me to see how close how much how much metabolic flexibility there really is when you start to look at it. Yeah.Harry Glorikian: Yeah. We've got to go talk to the monks.Linda Goodman: Absolutely. Absolutely. You know, we have that in mind. It sounds like an interesting travel experience. Yeah.Harry Glorikian: So I want to jump back for a second because. You guys don't necessarily have from what I have pieced together, the normal sort of like startup story. Right. First of all, you're an all female founding team, right? Highly unusual, right? Not something I see every day. You guys started at an accelerator program in San Francisco called Age One.Ashley Zehnder: Age One.Harry Glorikian: And then you moved to QB3 and the East Bay Innovation Center.Ashley Zehnder: Yep.Harry Glorikian: And then I think they helped you with some paid interns.Ashley Zehnder: Well, we got some from Berkeley. Yep, we did.Harry Glorikian: Yeah. And then you went through a SBIR grant.Ashley Zehnder: A couple of them.Harry Glorikian: From the Small Business Administration. And then a small business technology transfer grant from the Human Genome Research Initiative at NIH. Right.Ashley Zehnder: Yep.Harry Glorikian: I'm hopeful, hopefully my notes are all correct. Talk a little bit about the on ramp or infrastructure today for sort of seed stage startups like you. I mean, what were the most important resources?Ashley Zehnder: This is such an important conversation. I'm really glad you're asking this question. We had a call with a reporter from Business Insider yesterday who was talking to all three of us about this early founder ecosystems in biotech and sort of East Coast versus West Coast ways of starting biotechnology companies. Right. And that is a whole do a whole podcast on that, let me tell you. But I will say that there are a lot of resources for, let's call them founder led bio. Right. In the West Coast, which is kind of the buzzword these days, but people really supporting the scientists who originate the concepts and training them to be founders as opposed to assuming that you need to bring in an experienced CEO to run a company at this stage. Right. So I think we were very fortunate to meet Laura Deming at Stanford, who is one of the founding VCs. And longevity before that was a buzz word, right? She was one of the first longevity funds, literally Longevity Fund, and is really been a champion of founders, starting companies and really training founders to start companies who are deep science founders. So we started in age one. It was the first batch of age one. We're still very close to that cohort of companies doing interesting things from machine learning and image analysis through pure therapeutics development. And then Laura really helped us, her, her. We asked her later, like, why did you end up investing in us? She said, Well, the science was amazing.Ashley Zehnder: This is totally a field with so much promise. I just needed to teach you guys how to pitch. The science was there, right? So she helped me just how to pitch and how to use less science words in our pitches, which we're still working on to some extent. But then it was this balanced approach of taking in some venture money to really support the growth of the company, but balance with some of this non-dilutive funding for specific projects where it made sense and some of that was some of that in the early stage is validation, right? Having having funding through groups like NHGRI, having an early partnership with a company like Novo Nordisk, which provided also some non-dilutive funding for the company, really validated all of the science that we were doing because we were first time founders, because we're a little bit outside of the normal profile. For me, I don't feel weird being a female founder only because 80% of veterinarians are female. Like, I'm used to being in a room with all women. You go to a bio conference, it's not the same thing, right? So for us, we're just we are who we are. Right. But it's helpful, I think, to get some of that external validation and then really be able to use that to to start to build on programs and show progress.Ashley Zehnder: And then it becomes more about the data and the progress and what you can do with it. So that's a lot of how we started the company. There's I said there's a lot of support in the West Coast for this kind of thing. There's great programs like Berkeley Foreman Fund Talks, which I worked, which I was in as well, just about logistics around starting companies. There's a lot of good startup accelerators. I've got a really amazing all of us, how amazing a network of founders who we can reach out to on different. I got four or five different Slack channels of founders that I could reach out to for all kinds of advice. And usually it's always good to have a company that's one or two stages ahead of you, like talking to folks who IPO'd or something last year is is not as helpful as folks who recently raised a series B, right. And figuring out what those milestones look like and then particularly those that have taken mostly money from tech investors like we have all the lifeforce capital who led our last round is also has funded some very good therapeutics companies, Sonoma Therapeutics and Second Genome and other therapeutics companies as well. So I think it's it's helpful to see how people balance the needs of the companies at different stages in what you need.Harry Glorikian: But so do you guys think that you could have started Fauna ten years ago? I mean, did the support systems exist for starting a company like this?Ashley Zehnder: Well, no, for two reasons. We couldn't have started Fauna ten years ago. One is the data just simply wasn't in a place that the company was a tractable strategy. Everything was still too expensive and we had really shitty genomes for a few species at that point. And B, I think there really wasn't the kind of groundswell of support for deeply scientific technical founders to start their own companies and train them to be the kind of leaders they need to be to run those companies for a longer term. So I think it's a confluence of those things and being in an environment like Stanford that really encourages people to to try startups, it's not a crazy idea. Like people don't look at you like you're your heads backwards. If you start to start a company at Stanford, it's like, okay, cool. Like, when are you launching? You know.Harry Glorikian: I think it's the opposite.Ashley Zehnder: Yeah, exactly. Exactly. Like, why aren't you have a company yet? Whereas you know, a lot, many, many, many, many other places like that is seen as a very strange thing to do. So I think the environment plays a huge role. Yeah, for sure.Harry Glorikian: Yeah. I think between East Coast and West Coast too, there's.Ashley Zehnder: That's a whole, we should have a whole 'nother podcast on that.Harry Glorikian: Yeah. Yeah, exactly. Well, I live here and I was I was born and raised on the West and I remember there and I came here and I was like, Oh, this is where you are not in Kansas anymore. Like, this place is different. So, I mean, I'm hoping that the East Coast is actually embracing risk a little bit more and sort of stepping out on the edge. But it's really slow. They don't call it New England for nothing. So. But, you know, it was great having you both on the show. I this was great. I we covered a lot of ground. I'm sure people's heads are spinning, thinking about, you know, you know, different animal species and how that's going to play into this. And I mean. It really does sound like I know we have to do the hard work, but there's a lot of computational effort that has to go on here to sort of. Make sense of this and bring it all together and align it so that you can be looking at it properly and make the right decisions going forward.Ashley Zehnder: Yep. Millions of data points coming together to find drug targets for sure.Harry Glorikian: So thanks for being on the show. And you know, I wish you guys incredible luck.Ashley Zehnder: Thanks, Harry, so much. This was fun.Linda Goodman: Thanks for having us.Harry Glorikian: Thanks.Harry Glorikian: That's it for this week's episode. You can find a full transcript of this episode as well as the full archive of episodes of The Harry Glorikian Show and MoneyBall Medicine at our website. Just go to glorikian.com and click on the tab Podcasts.I'd like to thank our listeners for boosting The Harry Glorikian Show into the top three percent of global podcasts.If you want to be sure to get every new episode of the show automatically, be sure to open Apple Podcasts or your favorite podcast player and hit follow or subscribe. Don't forget to leave us a rating and review on Apple Podcasts. And we always love to hear from listeners on Twitter, where you can find me at hglorikian.Thanks for listening, stay healthy, and be sure to tune in two weeks from now for our next interview.

Lounge Cinematica Podcast Radio | Temporada 2 Episodio 2x14 Emision del 04/03/22 ..::Tracklist::.. 01. Juan Carlos Calderon y Su Taller De Musica - Fiesta -- Introduccion Lounge Cinematica Podcast Radio Temporada 2 02. Carlo Savina - Lisa And The Devil (Lisa E Il Diavolo) (Javier Di Granti Suite) [mejor track de la semana] Fetching A Ride / Main Titles / Romantic Mood / Finale 03. Franco Micalizzi - Il Sole È Di Tutti (Javier Di Granti Suite) Seq.2 / Seq.10 / Seq.7 / Seq.11 - Finale -- Intermedio: "La Rebelion De Las Muertas" (1973). Trailer + Tema de la pelicula compuesto por Juan Carlos Calderon. 04. Vito Tommaso - Lacrime D'Amore (Sequence 9) 05. Gregorio García Segura - La Chica Del Molino Rojo 06. Fabio Fabor - Atelier Roma / Jazzy Diamonds / Noblesse Oblige Direccion y seleccion musical de Javier Di Granti Narracion de Xavi Martin Jingles Don Draper de Jordi Ribes

On Episode 90 we chat to Steve Morgan who is the director of the ABT tournaments and Fishing Monthly magazine. In addition to the Steve's high level of success within the Tournament scene, Steve is an avid fly fisho who has held multiple records for long Tail Tuna form as far back as the 90's. Steve has also caught a stack of Threadfin, Jewfish and Bass on fly in SEQ which is where Steve is from. On this show we talk about the on flow of tournaments, what they mean to the industry as a whole and how they raise the standard of fishing for everyone. Also on this show we kick the show off by talking about Coldwater v Tropical fly lines and also some great chat about managing tangles also. This show is brought to you by Manic Tackle Project and Beast Brushes

One this our 85th show, we venture into one of the squirliest subjects that we have had to talk about on this podcast and that is how to navigate the bullshit on Social Media when your learning fly fishing. We are joined on this how by SEQ flyfishing lord Sammy Hine who recently converted to fly fishing from spin in this time of social media dominating the source of information for new comers to our sport. This was a great show for those that are miffed with fly fishing because of the smoke and mirrors fishing pages on Social Media generally offer. Follow Sam Hine over at @fullcreamfishing This show is brought to you by Manic Tackle and Beast Brushes