Podcasts about immunomodulation

Send us a textDr. Kilian Kelly, Ph.D. is Chief Executive Officer and Managing Director of Cynata Therapeutics ( https://cynata.com/ ), a stem cell and regenerative medicine company that is known for its proprietary Cymerus platform, for the scalable and consistent production of mesenchymal stem cell (MSC)-based therapies.Unlike traditional MSC therapies that rely on multiple donors, the Cymerus manufacturing process ensures that cells for therapeutic use can be produced in virtually limitless quantities from a single donor – making the opportunities endless and attractive from a manufacturing standpoint. The company has completed Phase I studies for Graft vs Host disease & Diabetic Foot Ulcers and have a number of Phase II, and even have a Phase III clinical trial, in progress.Dr. Kelly has over 20 years' experience in biopharmaceutical research and development, including almost 15 years focused on the development of mesenchymal stem cell (MSC) based therapies. He joined Cynata in March 2014, initially as Vice President, Product Development, then Chief Operating Officer from May 2019, and since July 2023 has been CEO & MD. At Cynata, he has overseen all stages of the development of the Cymerus induced pluripotent stem cell (iPSC)-derived MSC technology, including the first completed clinical trial of any iPSC-derived product worldwide.Dr. Kelly previously held positions at Biota Pharmaceuticals, Mesoblast Limited, Kendle International, Amgen and AstraZeneca. Dr. Kelly holds a Masters in Pharmacy degree from the Robert Gordon University, Aberdeen, a Ph.D. in Pharmaceutical Sciences from Strathclyde University, Glasgow, and he is a Graduate of the Australian Institute of Company Directors (AICD), Melbourne. He is a member of the International Society for Cell and Gene Therapy (ISCT), the International Society for Stem Cell Research (ISSCR), the Royal Pharmaceutical Society and the AICD.Dr. Kelly also serves on the ISCT Asia-Pacific Industry Committee, the ISSCR Best Practices Working Group for the Development of PSC-Derived Therapies and the Industry Interface Committee of the Center for Commercialization of Regenerative Medicine (CCRM) Australia.#KilianKelly #CynataTherapeutics #InducedPluripotentStemCells #MesenchymalStemCells #Immunomodulation #Immunoregulation #Mesenchymoangioblasts #GraftVersusHostDisease #GVHD #MSC #iPSC #IschaemicHeartDisease #Osteoarthritis #AcuteRespiratoryDistressSyndrome #ARDS #Inflammation #Secretome #Paracrine #RegenerativeMedicine #DiabeticWounds #KidneyTransplantation #ProgressPotentialAndPossibilities #IraPastor #Podcast #Podcaster #ViralPodcast #STEM #Innovation #Technology #Science #ResearchSupport the show

This Real Science Exchange podcast episode was recorded during a webinar from Balchem's Real Science Lecture Series. You can find it at balchem.com/realscience.Feeding rumen-protected choline in early lactation has consistently increased milk yield and energy-corrected milk yield, which is more pronounced when cows are fed diets low in metabolizable methionine. Choline feeding also increases milk fat and protein yield, minimizes body condition loss in early lactation, and reduces postpartum disease incidence. Dr. McFadden presents three topics about choline biology in the dairy cow. (01:45)Why should we consider fatty acid feeding when feeding methyl donors like choline and methionine?Choline degradation in the rumen and small intestine, focusing on the role of triethylamine oxide Why should we consider lysophosphatidylcholine as an immunomodulator in fresh cows and preweaning calves?Fatty acid nutrition to optimize methyl donor efficiency. (4:02)Fatty liver is a concern for fresh cows because of its relationship with ketosis, poor fertility and compromised milk production. Cows with fatty liver exhibit low circulating concentrations of phosphatidylcholine, which is a component of very low-density lipoproteins (VLDL) that transport triglycerides out of the liver. Feeding rumen-protected choline lowers liver triglyceride deposition by supporting the synthesis of phosphatidylcholine and thus, VLDL. Dr. McFadden goes on to explain the two different pathways for phosphatidylcholine in the liver and how those interact with fatty acid metabolism. He describes several experiments that have investigated how rumen-protected choline and supplemental fatty acids interact in lactating cows. Low phosphatidylcholine supply is a key feature of fatty liver in dairy cows, likely due to low polyunsaturated fatty acid (PUFA) and low choline supplies. Delivery of post-ruminal PUFA may support phosphatidylcholine synthesis with accompanying improvements in insulin sensitivity, body condition maintenance, and inflammation, but interactions with dietary fatty acid digestibility should be considered. Dr. McFadden gives a list of considerations for fresh cow diets incorporating fat and choline supplementation. Gastrointestinal choline degradation and trimethylamine N-oxide (TMAO)  (16:58)Unprotected choline is almost totally degraded in the rumen. Microbes convert choline into trimethylamine (TMA) which is then converted to TMAO in the liver. Rumen-protected choline allows for a large proportion of choline to reach the small intestine intact. However, research shows that choline can also be degraded by microbes in the small intestine in the same pathway, limiting choline bioavailability. Plasma TMAO accumulation is associated with non-alcoholic fatty liver disease, inflammation, insulin resistance, obesity, oxidative stress, and cardiovascular disease in rodent and human models. Little research was available regarding if the relationship between TMAO and poor health was causative or just associative. Dr. McFadden's lab infused cows intravenously with TMAO and found that TMAO did not modify milk production or glucose tolerance in early lactation cows.  TMAO does not appear to influence energy metabolism or health in early lactation cows. Choline is subject to both ruminal and lower-gut degradation to TMA, and that influence on choline bioavailability needs to be defined. Data in non-ruminants suggests that unsaturated fatty acid feeding can shift the gut microbes to slow TMA formation. Lysophosphatidylcholine and immunomodulation (28:45)Dr. McFadden gives an overview of neutrophil activation and the oxidative burst that contributes to pathogen killing. The ability to elicit the oxidative burst is diminished in pre-weaned calves and transition cows. When cows were given endotoxin to cause an immune response, circulating lysophosphatidylcholine was decreased. In rodent models, lysophosphatidylcholine promotes the oxidative burst and suppresses long-term inflammation in response to bacterial infection. Dr. McFadden cultured neutrophils from pre-weaned calves with lysophosphatidylcholine and observed an enhanced oxidative burst.Immunosuppression is characterized by low circulating lysophosphatidylcholine concentrations in dairy cows. In  vitro data suggests lysophosphatidylcholine can activate neutrophils, and rumen-protected choline increases circulating lysophosphatidylcholine. Future research is likely to define an immunomodulatory role for choline. Dr. McFadden takes questions from the webinar audience. (38:07)Please subscribe and share with your industry friends to invite more people to join us at the Real Science Exchange virtual pub table.  If you want one of our Real Science Exchange t-shirts, screenshot your rating, review, or subscription, and email a picture to anh.marketing@balchem.com. Include your size and mailing address, and we'll mail you a shirt.

Today we are diving into the world of natural turkey tail mushroom supplements. I am excited to introduce our special guest, the founder and owner of Tremetes, LLC. Our guest today brings nearly two decades of broad commercial experience with some of the world's leading global life science companies. With extensive knowledge across multiple therapeutic areas such as diabetes, cardiovascular and metabolic diseases, and oncology, he has a profound understanding of the healthcare landscape. This wealth of experience has been instrumental in the successful creation and growth of Tremetes, LLC, where precision and quality are paramount. At Tremetes, LLC, our guest has spearheaded the sustainable cultivation of turkey tail mushrooms, employing advanced techniques to ensure the highest quality product. His commitment to natural health solutions and rigorous testing for safety underscores his dedication to providing consumers with top-tier turkey tail supplements. Topics: 1. Introduction - The Pacific Yew Tree and the discovery of endophytic fungi that have a symbiotic relationship with the tree. 2. Historical Discoveries - Penicillin discovery 3. Nature's Complex Solutions - Nature's intricate methods for solving complex problems compared to the simple "single hammer" approach 4. Turkey Tail Mushrooms - Traditional uses - Explanation of polysaccharides - Overview of PSK, PSP, and Beta Glucans - Use in Asian cancer treatments - Immune system modulation 5. Mushroom Supplement Industry - Prevalence of products from China/India with misleading "packaged in USA" labels - Common use of extracts and fillers with unclear content - Most US supplies consist of mycelium biomass - Genuine turkey tail products are rare and often not produced in clean environments - Turkey tail mushrooms are common in forests but difficult to find 6. Tremetes - Focus on authenticity, quality, and education - Small batch facility ensuring high standards of cleanliness and control - Detailed practices and facility operations - Products are rigorously tested by third-party labs - Instructions on extracting polysaccharides for maximum benefit - Answering the question “How long should I take this?” - Recipes Check out Tremetes, LLC Use code CHLOE15 for 15% off your Turkey Tail Mushroom order Thanks for tuning in! Get Chloe's Book Today! "⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠75 Gut-Healing Strategies & Biohacks⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠" Follow Chloe on Instagram ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠@synthesisofwellness⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ Follow Chloe on TikTok @chloe_c_porter Visit ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠synthesisofwellness.com⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ to purchase products, subscribe to our mailing list, and more! --- Support this podcast: https://podcasters.spotify.com/pod/show/chloe-porter6/support

In today's episode, we explore the role of Thymosin Alpha 1 Peptide in modulating the immune system, specifically its effects on Th1 and Th2 responses. The episode further delves into the mechanisms by which Borrelia burgdorferi evades immune detection and offers strategies to enhance immune effectiveness against this stealthy pathogen. Additionally, we discuss the broader implications of immune modulation in chronic Lyme disease and mold exposures. Topics: Introduction Recap of the series on Lyme and mold Highlighting the key steps in the biotoxin illness resolution process Importance of working with a medical professional Key Steps in Biotoxin Illness Resolution Lowering inflammation Lipid replacement therapy (phospholipids) Use of antimicrobial and antiparasitic herbs for Lyme and coinfections Employing binders to eliminate toxins and reduce inflammation Checking for MARCoNS and utilizing treatments like silver spray or biofilm busters (e.g., xylitol) Detoxification post-MARCoNS clearance using agents like chlorella and glutathione Assessing and normalizing various health markers (e.g., ADH, osmolality, MMP9, C4a, C3a, TGF-beta, sex hormones) Additional Resources and Episodes Early stages of Lyme infection and Herxheimer reaction: Episode 116 Chronic inflammation and biotoxin management: Episode 117 Role of binders in interrupting enterohepatic circulation and toxin elimination Discussion on Biofilm Importance of addressing biofilm in antimicrobial therapies Potential supplements and strategies (e.g., garlic, oil of oregano, stevia) Overview of Lyme Disease Impact & Immune Function Chronic inflammation due to miscommunication between the innate and adaptive immune systems + dysregulated adaptive responses How borrelia evades the immune responses Immunomodulation in Lyme Disease Background on immune modulation Role of T cells in adaptive immune response Th1 and Th2 cell imbalance in chronic Lyme Strategies to support Th1 cells and decrease Th2 response Focus on Thymosin Alpha 1 Benefits of Thymosin Alpha 1 in modulating immune function Promoting Th1 response and managing Th2 dominance Effects on regulatory T cells (Tregs) and immune tolerance Conclusion Reminder to work with a Lyme literate or biotoxin illness literate medical professional Thanks for tuning in! Get Chloe's Book Today! "⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠75 Gut-Healing Strategies & Biohacks⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠" If you liked this episode, please leave a rating and review or share it to your stories over on Instagram. If you tag @synthesisofwellness, Chloe would love to personally thank you for listening! Follow Chloe on Instagram ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠@synthesisofwellness⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ Follow Chloe on TikTok @chloe_c_porter Visit ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠synthesisofwellness.com⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ to purchase products, subscribe to our mailing list, and more! Or visit ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠linktr.ee/synthesisofwellness⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ to see all of Chloe's links, schedule a BioPhotonic Scanner consult with Chloe, or support the show! Thanks again for tuning in! --- Support this podcast: https://podcasters.spotify.com/pod/show/chloe-porter6/support

For more information, visit https://thecirsgroup.com   CIRS, or Chronic Inflammatory Response Syndrome, is a chronic illness that occurs in 25% of the population that gets exposed to environmental toxins like mold, red tide, spider or tick bites, and even some vaccines and viruses. Today, we have a special return guest Dr. Christian Navarro-Torres, and we are going off script, away from the clinically proven path for healing from CIRS with the Shoemaker Protocol: Exploring the potential for good that comes in the form of pure Nicotine. This may be a controversial topic - but as always, this is not medical advice! We are exploring the possibilities for treatment in the future and hopefully opening the conversation around alternative methods to help the body recover from CIRS. More research is needed, but it's fun to play “what if.” For more information, support, and resources in your own CIRS healing journey, visit TheCIRSGroup.com   TIME STAMPS: 0:00 Intro and disclaimer 1:24 What is Nicotine? 3:00 Overlap between Nicotine and VIP 4:35 Immunomodulation by both Nicotine and VIP 6:03 Nicotine can stimulate VIP receptors 6:51 Cancer risk with Nicotine use 8:30 Smoking/Vaping vs taking Nicotine in pure form 10:05 Long COVID symptom resolution with Nicotine 15:12 Jacie's experience with Nicotine 17:25 Christian's experience with Nicotine 22:13 Barbara's experience with Nicotine 24:32 Nicotine recommendations: NicNac 26:32 Nicotine dosage 28:13 Arginine supplementation with Nicotine 30:40 Cravings and withdrawal concerns 32:40 Potential in the future for CIRS patients 37:15 Outro   Follow Christian! https://www.instagram.com/cirslab Sign up for the CIRSLab newsletter: https://us12.list-manage.com/contact-form?u=81c43ceaa0a2d5b619dcbd6cf&form_id=7c935313230b949627a90f75fcf161e3   The CIRS Group: Support Community: https://thecirsgroup.com Instagram: https://www.instagram.com/thecirsgroup/   Find Jacie for carnivore, lifestyle and limbic resources: Instagram: https://www.instagram.com/ladycarnivory YouTube: https://www.youtube.com/@LadyCarnivory Blog: https://www.ladycarnivory.com/ Limbic Training Community: https://www.wired4healing.com   Find Barbara for business/finance tips and coaching: Website: https://www.actlikebarbara.com/ Instagram: https://www.instagram.com/actlikebarbara/ YouTube: https://www.youtube.com/@actlikebarbara HELPFUL LINKS: VIP Spray episode: https://youtu.be/A3YXtkYMnL0?si=mSSC-nwWrYTjFcQ6 NicNac, use Christian's discount code CIRSLAB: https://www.nicnac.com/ Come to CIRSx: https://www.cirsx.com/   Jacie is a 4 year carnivore, certified nutrition coach, and carnivore recipe developer determined to share the life changing information of carnivore and CIRS to anyone who will listen. Barbara is a coach, facilitator, speaker, 3 year carnivore, and a big fan of health and freedom. Together, they co-founded The CIRS Group, an online support community to help people that are struggling with their CIRS diagnosis and treatment.   Catch Jacie and Barbara on Judy Cho's podcast to learn more about their health journeys and why they started The CIRS Group: When Carnivores are Affected by Mold Illness - Jacie Gregory & Barbara Williams - https://youtu.be/CR8Uj-d_fok

Dr. Ira Spector, PhD is CEO and a Co-Founder of SFA Therapeutics ( https://sfatherapeutics.com/ ), a microbiome-derived biopharma company focused on new advancements in the treatment inflammatory diseases. Dr. Spector is an experienced drug developer, with over 30 years of experience. He has helped develop 34 approved drugs, including Enbrel, Effexor, Protonix, Prevenar-13, Mylotarg at Wyeth/Pfizer, where he was Vice President of Clinical Operations and Vice-Chief of Development. At Allergan, Dr. Spector helped develop Ozurdex for Diabetic Macular Edema and Retinal Venous Occlusion, Botox for Overactive Bladder, Botox for Chronic Migraine, Juvederm XL and Botox for Cerebral Palsy. Prior to Wyeth, he was Vice President and Partner at the PA Consulting Group. Before founding SFA Therapeutics, Dr. Spector was Executive Vice President of Analytics & Consulting at ICON. Dr. Spector holds BS degrees in Physics and Electrical Engineering from Washington University, where he was a Langsdorf Fellow, an MBA from Drexel University, and a PhD in Health Sciences from UMDNJ. Support the show

What should rheumatologists know about what we've learned about COVID-19 and long COVID in 2023? Hosted by Dr. Leonard Calabrese. ·       Intro 0:11 ·       In this episode 0:21 ·       2023: current status and controversies 0:35 ·       What is going on with COVID-19? 01:53 ·       What do we know about vaccine responses? What should we be telling our patients about vaccines in our immunocompromised population? 2:58 ·       Lancet Rheumatology MELODY study summary 3:08 ·       What about patients within the rheumatic and autoimmune disease space? 4:15 ·       Who is immunocompromised and why does it matter? 5:11 ·       What is the immunosuppression we are giving them? 6:39 ·       What to tell patients about getting vaccinated 8:56 ·       Long COVID 10:09 ·       What is long COVID? 10:26 ·       JAMA Network Open study on prevalence and characteristics associated with post-COVID conditions 14:19 ·       In the clinical arena, what should rheumatologists be thinking about? 16:38 ·       What about pathogenesis? What do we know about the controversies in this area? 18:58 ·       Autoimmunity: COVID-19 and autoimmune response 20:45 ·       What about therapies? 22:22 ·       The next generation of rheum agents: Immunomodulation with neonatal Fc receptor targeting? 24:40 ·       A question for the rheumatology community: do patients with immune mediated diseases get more long COVID than the control population? 25:40 ·       In conclusion 27:37 ·       Thanks for listening 28:38 Leonard H. Calabrese, DO, is the chief medical editor, Healio Rheumatology, and professor of medicine, Cleveland Clinic Lerner College of Medicine of Case Western Reserve University, and RJ Fasenmyer chair of clinical immunology at the Cleveland Clinic. Disclosures: Calabrese reports professional relationships with AbbVie, AstraZeneca, Bristol Myers Squibb, Galvani, Genentech, GlaxoSmithKline, Janssen, Novartis, Regeneron, Sanofi and UCB.. We'd love to hear from you! Send your comments/questions to Dr. Brown at rheuminationspodcast@healio.com. Follow us on Twitter @HRheuminations @AdamJBrownMD @HealioRheum.

The movement toward personalized treatments with immunomodulatory effects has made testing biomarkers of immunomodulation increasingly important. Careful monitoring of complement factors and cytokines can help prevent any unintended consequences that may arise from these new medications. In this eBook, Altasciences shares comprehensive information about including the testing of these biomarkers in your drug development program. Contents include: • REVIEW: Complement Factors and Cytokines • SOLUTIONS: Biomarker Analysis • CASE STUDY: Comparing Cytokine Data to In-Life Parameters on Nonhuman Primates in Nonclinical Toxicology Studies Click here to download a readable, PDF version of this eBook: https://www.altasciences.com/sites/default/files/2022-06/Key_Biomarkers_of_Immunomodulation.pdf About Altasciences: Altasciences is an integrated drug development solution company offering pharmaceutical and biotechnology companies a proven, flexible approach to preclinical and clinical pharmacology studies, including formulation, manufacturing, and analytical services. For over 25 years, Altasciences has been partnering with sponsors to help support educated, faster, and more complete early drug development decisions. Altasciences' integrated, full-service solutions include preclinical safety testing, clinical pharmacology and proof of concept, bioanalysis, program management, medical writing, biostatistics, clinical monitoring, and data management, all customizable to specific sponsor requirements. Altasciences helps sponsors get better drugs to the people who need them, faster.

Jordan Joiner received her Bachelors in Chemical and Biological Engineering from the University of Alabama in 2015, and she is currently a 4th year Pharmaceutical Sciences Ph.D. Candidate in the UNC Eshelman School of Pharmacy. Uniquely, before pursuing her Ph.D., Jordan worked at Evonik, a specialty chemical company, as a Process Engineer for 3 years. On this episode Jordan dives into how she made the decision to go back to university for her Ph.D. after 3 years of working in the industry, and what it's been like along the way. Links mentioned in the episode are below. Dayton Lab website: https://daytonlab.sites.unc.edu/ Benhabbour Lab website: https://benhabbour.web.unc.edu/ Jordan's Journal of Immunology paper, Focused Ultrasound for Immunomodulation of the Tumor Microenvironment: https://www.jimmunol.org/content/205/9/2327 For more information on The BME Grad Podcast, visit the Joint Department of BME at UNC and NC State's website: bme.unc.edu/home/news-events/the-bme-grad-podcast/ Connect with or reach out to Host, Allie Mitzak, on LinkedIn: www.linkedin.com/in/allie-mitzak

Jordan Joiner received her Bachelors in Chemical and Biological Engineering from the University of Alabama in 2015, and she is currently a 4th year Pharmaceutical Sciences Ph.D. Candidate in the UNC Eshelman School of Pharmacy. Uniquely, before pursuing her Ph.D., Jordan worked at Evonik, a specialty chemical company, as a Process Engineer for 3 years. On this episode Jordan dives into how she made the decision to go back to university for her Ph.D. after 3 years of working in the industry, and what it's been like along the way. Links mentioned in the episode are below. Dayton Lab website: https://daytonlab.sites.unc.edu/ Benhabbour Lab website: https://benhabbour.web.unc.edu/ Jordan's Journal of Immunology paper, Focused Ultrasound for Immunomodulation of the Tumor Microenvironment: https://www.jimmunol.org/content/205/9/2327 For more information on The BME Grad Podcast, visit the Joint Department of BME at UNC and NC State's website: bme.unc.edu/home/news-events/the-bme-grad-podcast/ Connect with or reach out to Host, Allie Mitzak, on LinkedIn: www.linkedin.com/in/allie-mitzak

Keke Fairfax joins Immune to discuss the work from her laboratory on understanding how maternal schistosomiasis impairs IL-4 production and B cell expansion in offspring, and modulation of macrophage immunometabolism by helminths. Hosts: Vincent Racaniello, Stephanie Langel, Cynthia Leifer, and Brianne Barker Guest: Keke Fairfax Subscribe (free): iTunes, Google Podcasts. RSS, email Become a patron of Immune! Links for this episode Maternal schistosomiasis impairs offspring immunity (PloS Path) Helminth modulation of macrophage immunometabolism (Immune) Time stamps by Jolene. Thanks! Music by Steve Neal. Immune logo image by Blausen Medical Send your immunology questions and comments to immune@microbe.tv

Interested in learning about natural therapies used in IBD? Dr. Steven Sandberg-Lewis follows a three-point approach to encouraging and maintaining remission in Crohn's and colitis, which includes diet, immunomodulation and stress management. Hear about the importance of physical as well as emotional healing, the different types of colitis, a musical rendition of the Bristol Stool Chart and more. Lindsey Parsons, your host, helps clients solve gut issues and reverse autoimmune disease naturally. She's a Certified Health Coach at High Desert Health in Tucson, Arizona. She coaches clients locally and nationwide. You can also follow Lindsey on Facebook, Twitter, Instagram or Pinterest or reach her via email at lindsey@highdeserthealthcoaching.com to set up a free 30-minute Gut Healing Breakthrough Session. Show Notes

It would be hard to find any health practitioner - traditional, functional, or otherwise - who doesn’t acknowledge the importance of consuming omega-3 fatty acids. Supplements in the form of fish oil or krill oil are widely recommended and consumed, and come with claims of cardiovascular disease prevention, cognitive benefits, and anti-inflammatory properties. But is it really a good idea to get your omega-3s in a gel cap rather than from food? And do they really do everything the media would have you believe? On this podcast, NBT Scientific Director Megan Hall and I discuss omega-3 fatty acids: what they are, what they’re good for, and the best ways to get them. Megan outlines the different types of omega-3 and explains why some are better than others. She also explains why some health claims are overblown, and why buying fish oil supplements may not be the best health strategy. Be sure to follow along with Megan’s outline for this podcast.  Here’s the outline of this interview with Megan Hall: [00:04:30] Blood flow restriction (BFR) training; Podcast: Blood Flow Restriction Training for Improved Strength, Performance, and Healthspan with Dr Jim Stray-Gundersen MD. [00:04:51] Podcast: Wired to Run: Why Your Brain Needs Exercise, David Raichlen. [00:05:41] What are omega-3 fatty acids? [00:06:31] Picture of omega-3 fatty acids. [00:08:40] Finding omega-3s in the diet; Review: Saini, Ramesh Kumar, and Young-Soo Keum. "Omega-3 and omega-6 polyunsaturated fatty acids: Dietary sources, metabolism, and significance—A review." Life sciences 203 (2018): 255-267. [00:09:16] Poor conversion from ALA to EPA/DHA: Gerster, Helga. "Can adults adequately convert a-linolenic acid (18: 3n-3) to eicosapentaenoic acid (20: 5n-3) and docosahexaenoic acid (22: 6n-3)?." International journal for vitamin and nutrition research 68.3 (1998): 159-173. [00:10:56] Why EPA and DHA are important. [00:11:38] Conditions associated with inadequate omega-3 intake. [00:12:02] Whole foods vs. supplements; other micronutrients. [00:12:42] Krill oil vs. fish oil; Studies: 1. Ulven, Stine M., et al. "Metabolic effects of krill oil are essentially similar to those of fish oil but at lower dose of EPA and DHA, in healthy volunteers." Lipids 46.1 (2011): 37-46. 2. Schuchardt, Jan Philipp, et al. "Incorporation of EPA and DHA into plasma phospholipids in response to different omega-3 fatty acid formulations-a comparative bioavailability study of fish oil vs. krill oil." Lipids in health and disease 10.1 (2011): 1-7. 3. Maki, Kevin C., et al. "Krill oil supplementation increases plasma concentrations of eicosapentaenoic and docosahexaenoic acids in overweight and obese men and women." Nutrition research 29.9 (2009): 609-615. 4. Mödinger, Yvonne, et al. "Plasma kinetics of choline and choline metabolites after a single dose of SuperbaBoostTM krill oil or choline bitartrate in healthy volunteers." Nutrients 11.10 (2019): 2548. [00:16:59] Megan's outline for this podcast. [00:18:21] Algae-based omega-3 supplements. [00:19:40] Omega 6:3 ratio; Paper: Simopoulos, Artemis P. "The importance of the ratio of omega-6/omega-3 essential fatty acids." Biomedicine & pharmacotherapy 56.8 (2002): 365-379. [00:25:54] Should we be supplementing with grams of fish oil? Studies: 1. De Magalhães, João Pedro, et al. "Fish oil supplements, longevity and aging." Aging (Albany NY) 8.8 (2016): 1578. 2. Strong, Randy, et al. "Longer lifespan in male mice treated with a weakly estrogenic agonist, an antioxidant, an α‐glucosidase inhibitor or a Nrf2‐inducer." Aging cell 15.5 (2016): 872-884. 3. López-Domínguez, José A., et al. "The influence of dietary fat source on life span in calorie restricted mice." Journals of Gerontology Series A: Biomedical Sciences and Medical Sciences 70.10 (2015): 1181-1188. [00:27:42] No support for omega-3 (fish oil) in the prevention of cardiovascular disease; Meta-analysis: Aung, Theingi, et al. "Associations of omega-3 fatty acid supplement use with cardiovascular disease risks: meta-analysis of 10 trials involving 77 917 individuals." JAMA cardiology 3.3 (2018): 225-233. [00:29:12] Signs you're supplementing too much fish oil. [00:30:26] Podcast: How Oxidative Stress Impacts Performance and Healthspan [00:30:43] Elevated blood glucose omega-3 supplementation; Study: Friday, Karen E., et al. "Elevated plasma glucose and lowered triglyceride levels from omega-3 fatty acid supplementation in type II diabetes." Diabetes care 12.4 (1989): 276-281. [00:31:01] Immunosuppressive effects of supplementing omega-3s: Fenton, Jenifer I., et al. "Immunomodulation by dietary long chain omega-3 fatty acids and the potential for adverse health outcomes." Prostaglandins, Leukotrienes and Essential Fatty Acids 89.6 (2013): 379-390. [00:34:17] Stages of life when omega-3s are especially important. [00:34:48] Specialized pro-resolving mediators; STEM Talk podcast episode: David LeMay Talks About Countering Inflammation with SPMS. [00:35:31] DHA to mitigate traumatic brain injury; Study: Bailes, Julian E., and Vimal Patel. "The potential for DHA to mitigate mild traumatic brain injury." Military medicine 179.suppl_11 (2014): 112-116. [00:35:45] DHA for cognitive function and aging; Study: Weiser, Michael J., Christopher M. Butt, and M. Hasan Mohajeri. "Docosahexaenoic acid and cognition throughout the lifespan." Nutrients 8.2 (2016): 99. [00:37:20] omega-3s for athletic performance; Review: Gammone, Maria Alessandra, et al. "Omega-3 polyunsaturated fatty acids: benefits and endpoints in sport." Nutrients 11.1 (2019): 46. [00:38:54] omega-3s during pregnancy; Studies: Greenberg, James A., Stacey J. Bell, and Wendy Van Ausdal. "Omega-3 fatty acid supplementation during pregnancy." Reviews in obstetrics and Gynecology 1.4 (2008): 162; 2. Braarud, Hanne Cecilie, et al. "Maternal DHA status during pregnancy has a positive impact on infant problem solving: a Norwegian prospective observation study." Nutrients 10.5 (2018): 529. [00:39:44] Excess omega-3 consumption during pregnancy could be detrimental to offspring; Study: Church, M. W., et al. "Excess omega-3 fatty acid consumption by mothers during pregnancy and lactation caused shorter life span and abnormal ABRs in old adult offspring." Neurotoxicology and teratology 32.2 (2010): 171-181. [00:40:12] Testing: The Omega Index test; Framingham Heart Study: Harris, William S., et al. "Erythrocyte long-chain omega-3 fatty acid levels are inversely associated with mortality and with incident cardiovascular disease: The Framingham Heart Study." Journal of clinical lipidology 12.3 (2018): 718-727. [00:42:34] Bottom line: More may not be better. [00:43:09] SMASH fish - sardines, mackerel, anchovies, salmon, herring (also black cod), 3-4x/week. [00:49:30] Schedule a free 15 min call with Megan.

Looking for the right gateway drug to help start up an insatiable medical literature habit? JournalJunkies, your ears are in the right place!Today we interview Dr James Galloway, rheumatologist, semi- ornithologist, clinical lecturer, and head of the TACTIC trial at King's Hospital.He helps guide us through the mysteries of immunomodulation in COVID in understandable terms. What do the trials show us? Why? And, what is on the COVID horizon? 02:00    Introductions02:45    Why the birds aren't coming to your garden04:45    The Recovery Trial08:00   Why Steroids?09:35    REMAP CAP13:45    The conflicting Tocilizumab data17: 40    What is Tocilizumab and why might it work?24:50     The value of CRP monitoring27:00      Who to give Tocilizumab to29:40     TACTIC trial34:30     Why study SGLT2 inhibitors37:00     The future Tx of Severe COVID40:00     The JournalSpotting Gateway drug

To learn more about the CellCore Biosciences' Detox Protocol visit www.thewellnesstrinity.com/cellcoredetox.   Veronica Leslie, Naturopath AKA the Health Doll, is an Agriculture Scientist turned Naturopath as well as co-founder and CEO of Root Cause Clinic. However after suffering a series of health crises and finding no direction in the conventional medical sphere, Veronica embarked upon a quest for answers by utilizing her training as a scientist and love of all things photonic to isolate and elucidate the unique root cause factors that were in fact behind her own ailments. Her current areas of specialty include but are not limited to: Lyme Disease, Stealth Pathogens, CIRS, and Immunomodulation using Bioenergetic, Herbal, Homeopathic, and Homeoprophylaxis healing modalities. In this podcast Veronica Leslie, Naturopath explains:   How the  "Secret Societies" tried to recruit her when she was younger to help with the global depopulation agenda What photonics is What biofrequency machines are and why the future is frequency Neuronal and immunological hijacking of parasites on the human and mammalian host can cause allergies How to eliminate allergies and how the CellCore products play a role in that How biophysics and quantum physics play a role in immune modulation and infection Her thoughts about the Bible To learn more about:   -Veronica Leslie, Naturopath  www.rootcauseclinic.co @healthdoll.co @rootcauseclinic.co   -CellCore Detox Protocol:  https://thewellnesstrinity.com/cellcoredetox     -Gluco Optimizer: https://thewellnesstrinity.com/cellcoreproducts  SOME WAYS YOU CAN HELP US SPREAD THE MESSAGE HEALTH   -Leave us a comment and/or review -Share the show -Visit our website: http://thewellnesstrinity.com/  -Visit our Facebook Page: https://www.facebook.com/thewellnesstrinity -Follow us on Instagram: https://www.instagram.com/the_wellness_trinity/  -Watch our other podcasts: https://thewellnesstrinity.com/podcast

With summer right around the corner, huge kiosks of sunscreen are on display at stores everywhere, reminding us to fear the sun. We’ve been told for years that sunlight is something to guard against - and, of course, most of us know someone who’s had a suspicious mole removed. But we also know the sun is needed for vitamin D production - plus, it just feels great on our skin! And obviously our ancestors weren’t slathering on Coppertone when they left the cave. It seems to be a no-win situation until you learn the facts about sunlight. NBT Scientific Director Megan Hall is with me today to talk about the critical role of sunlight for health and wellness. She outlines the many benefits of sun exposure that go far beyond vitamin D production and sets the record straight on UVA vs UVB rays, skin cancer, and how sunscreen is actually working against you. Here’s the outline of this interview with Megan Hall: [00:00:11] Megan's new puppy. [00:03:35] Podcast w/ Kira Furie: Breaking Through the Diet Culture: Medical Care for Every Size. [00:05:42] Vitamin D and conditions associated with low levels. [00:07:40] Book: Hidden Valley Road: Inside the Mind of an American Family, by Robert Kolker. [00:08:22] Optimal Levels and dosing of Vitamin D. [00:12:55] Vitamin D Calculator. [00:13:47] COVID-19 and Vitamin D; Studies: 1. Glicio, El James. "Vitamin D Level of Mild and Severe Elderly Cases of COVID-19: A Preliminary Report." Available at SSRN 3593258 (2020); 2. De Smet, Dieter, et al. "Vitamin D deficiency as risk factor for severe COVID-19: a convergence of two pandemics." medRxiv (2020); 3. D’Avolio, Antonio, et al. "25-hydroxyvitamin D concentrations are lower in patients with positive PCR for SARS-CoV-2." Nutrients 12.5 (2020): 1359; 4. Meltzer, David O., et al. "Association of Vitamin D Deficiency and Treatment with COVID-19 Incidence." medRxiv (2020). [00:15:20] Vitamin D and ACE2. [00:17:46] Benefits of sunshine beyond vitamin D. [00:18:01] Circadian rhythm. [00:18:29] Satchin Panda; Podcast: How to Use Time-Restricted Eating to Reverse Disease and Optimize Health. [00:18:30] Bill Lagakos; Podcast: Why You Should Eat Breakfast (and Other Secrets of Circadian Biology). [00:18:35] Nitric oxide. [00:19:01] Malcolm Kendrick; Podcasts: Why Cholesterol Levels Have No Effect on Cardiovascular Disease (And Things to Think about Instead) and A Statin Nation: Damaging Millions in a Brave New Post-health World. [00:19:25] Homocysteine; glycocalyx. [00:21:20] Ivor Cummins; Podcasts with Ivor: How Not to Die of Cardiovascular Disease and Coronary Artery Calcium (CAC): A Direct Measure of Cardiovascular Disease Risk. [00:22:24] UV exposure suppresses symptoms of metabolic syndrome; Study: Geldenhuys, Sian, et al. "Ultraviolet radiation suppresses obesity and symptoms of metabolic syndrome independently of vitamin D in mice fed a high-fat diet." Diabetes 63.11 (2014): 3759-3769. [00:22:54] Melatonin. [00:25:39] Serotonin; Study: Lambert, Gavin W., et al. "Effect of sunlight and season on serotonin turnover in the brain." The Lancet 360.9348 (2002): 1840-1842. [00:26:26] Immunomodulation. [00:26:45] Vitamin D and Multiple Sclerosis; Reduced risk of MS: van der Mei, Ingrid AF, et al. "Past exposure to sun, skin phenotype, and risk of multiple sclerosis: case-control study." Bmj 327.7410 (2003): 316; Reduced risk of depression and fatigue: Knippenberg, S., et al. "Higher levels of reported sun exposure, and not vitamin D status, are associated with less depressive symptoms and fatigue in multiple sclerosis." Acta Neurologica Scandinavica 129.2 (2014): 123-131; MRI neurodegeneration scores inversely associated with sun exposure: Zivadinov, Robert, et al. "Interdependence and contributions of sun exposure and vitamin D to MRI measures in multiple sclerosis." J Neurol Neurosurg Psychiatry 84.10 (2013): 1075-1081. [00:27:20] UV treatment increased glucagon-stimulated insulin secretion; Study: Colas, C., et al. "Insulin secretion and plasma 1, 25-(OH) 2D after UV-B irradiation in healthy adults." Hormone and metabolic research 21.3 (1989): 154-155. [00:27:27] Prevention and treatment of skin conditions; Study: Søyland, E., et al. "Sun exposure induces rapid immunological changes in skin and peripheral blood in patients with psoriasis." British Journal of Dermatology 164.2 (2011): 344-355. [00:27:49] Sun exposure related to life expectancy; Study: Lindqvist, Pelle G., et al. "Avoidance of sun exposure as a risk factor for major causes of death: a competing risk analysis of the Melanoma in Southern Sweden cohort." Journal of internal medicine 280.4 (2016): 375-387.  [00:30:14] Outline of this interview. [00:31:04] UVA and UVB rays; UVB needed for Vitamin D Production: Wacker, Matthias, and Michael F. Holick. "Sunlight and Vitamin D: A global perspective for health." Dermato-endocrinology 5.1 (2013): 51-108. [00:31:31] Inverse correlation between dose of UVB and melanoma: Study: Godar, Dianne E., Madhan Subramanian, and Stephen J. Merrill. "Cutaneous malignant melanoma incidences analyzed worldwide by sex, age, and skin type over personal Ultraviolet-B dose shows no role for sunburn but implies one for Vitamin D3." Dermato-endocrinology 9.1 (2017): e1267077. [00:33:43] Sunscreens; coral bleaching: Downs, Craig A., et al. "Toxicopathological effects of the sunscreen UV filter, oxybenzone (benzophenone-3), on coral planulae and cultured primary cells and its environmental contamination in Hawaii and the US Virgin Islands." Archives of environmental contamination and toxicology 70.2 (2016): 265-288.  [00:43:20] Join the discussion on the NBT forum when you support us on Patreon.

Thank you for joining us for our 2nd Cabral HouseCall of the weekend! I’m looking forward to sharing with you some of our community’s questions that have come in over the past few weeks… Let’s get started!  Carter: Hey Stephen! LOVE THE SHOW its so so helpful! I have had lyme disease for many years, I'm a 20'year old male and my life is destroyed from lyme. I have not yet found anything to help me get better.. i know i have had toxic mold exposure, heavy metals and environmental toxins in my body and parasites and a terrible gut. I have tried so many things and both years of antibiotics and functional medicine doctors as well. I'm very concerned with my diet, i eat only grass fed beef because its all I'm abke to tollerate and even that is now causing me bloating. I'm very lost on how to start healing myself.. probiotic? Detox? Immunomodulation? My immune system is attacking itself constantly as well via my mast cells from the years and years of having lyme and antibiotics i believe.. I'm just cery lost and it seems no one can figure me out.. any advice you have will help save my life so PLEASE AND THANK YOU to any advice you have.  Shelley: Hi, one of my friend's mom's suffers from chronic illness and can barely leave the bed for longer than a few hours a day. I was listening to a podcast and Dr. Cabral had talked a little about chronic diseases. I'm wondering if there are some naturopathic remedies that could maybe help improve her way of life? She's in constant pain. I don't know the details of what all is wrong, I just know what I've stated above. Thanks! Corinne: I’d love your insight on “hereditary” high cholesterol. My boyfriend has taken statins since age 24. His father had a heart attack at age 39 (and also was taking statins). I’ve come across so much information on the ability to reverse diseases by diet and lifestyle, particularly plant based diet, and am curious if this can be an approach for treating cholesterol that is said to be hereditary and thus requires medication for life. Of course that offers its own health risks and some argue it may not be an effect prevention against cardiovascular disease. To circle back around: is high cholesterol genetic, not just from adapting the lifestyle of your parents? Can it be treated without medication? Thank you! I look forward to your trusted information. Chelsea: I just started the 7 day cleanse and was wondering if it’s okay to miss a shake throughout the day? Not replace it with anything but I am just full from the other 3 that I don’t even want the 4th one at dinner Brynn: Hello! My name is Brynn. I am a 32 yr old woman and I struggle with Hyperthyroidism (hypothyroidism) and I would lovvvve to get of my Rx. I have been working with an endocrinologist for the last 3-4 years. Tired of feeling like I'm not the girl I once was. Always tired, weight gain regardless of being very active and a healthy eater, low libido, amenorrhea, not sleeping well, etc.. Would love to correct the problem (even tho I am told I will be on levothyroxine forever) but not sure where to start. Was hoping we could discuss my situation so I know what tests to buy and send to you..? Thanks so much for your time. Look forward to hearing back. Cheers, Brynn Jenett: Hello Dr. Cabral My son will be 12 in July. He is not even on the chart for growth and height. He only weighs 55lbs. He is a bit of a picky eater and doesn't care for most meats. Not big on soy or beans. He suffers from allergies as well so I am wondering if it is a gut issue. The doctor says his growth plates are displaying late bloomer syndrome and he is closer to a 10 year than an eleven year old. They said that if he doesn't grow, they can give him a shot of testosterone. Do you know how we can boost his growth naturally? Also, I want to get him on a good multi-vitamin with Omeag 3's, probiotics and Vitamin D. Could you possibly recommend a brand? Thank you so much for all that you do! Jenett Heidi: I'm 56 and in general good shape. Just wondering. ..I have rosacea. ..anyway to get rid of it? Also suffer from dry eyes and possibly a touch of ocular rosacea and am currently taking immunotherapy for allergies. Is there a certain diet, mineral or supplement that may help with the skin issue and allergies? Also have lots of anxiety, but try to manage it with exercise and regular sleep. I am taking armour thyroid too. Nothing life threatening, just life annoying! Ha! I heard you or the first time on the Foodheals podcast and am an avid listener:) My daughter lives in Boston so I may have to see you in person one of these days! Until then, I'd love your opinion/advice:) Thanks so much Rebecca: Hi Stephen, I heard you on the Skinny Confidential podcast. I've been looking for a great functional doctor and while I can google them and read individual reviews, I wanted to cut through the noise to find out if you had a great recommendation for someone in So Cal (preferably Newport Beach Area). Thank you, Rebecca - - - Specific Show Notes & Resources: http://StephenCabral.com/940 - - - Dr. Cabral's New Book, The Rain Barrel Effect https://amzn.to/2H0W7Ge - - - Join the Community & Get Your Questions Answered: http://CabralSupportGroup.com - - -   Dr. Cabral’s Most Popular Supplements: > “The Dr. Cabral Daily Protocol” (This is what Dr. Cabral does every day!) - - - > Dr. Cabral Detox  (The fastest way to get well, lose weight, and feel great!) - - - > Daily Nutritional Support Shake  (#1 “All-in-One recommendation in my practice) - - - > Daily Fruit & Vegetables Blend  (22 organic fruit & vegetables “greens powder”) - - - > CBD Oil  (Full-spectrum, 3rd part-tested & organically grown) - - - > Candida/Bacterial Overgrowth, Leaky Gut, Parasite & Speciality Supplement Packages - - - > See All Supplements: https://equilibriumnutrition.com/collections/supplements  - - -   Dr. Cabral’s Most Popular At-Home Lab Tests: > Hair Tissue Mineral Analysis (Test for mineral imbalances & heavy metal toxicity) - - - > Organic Acids Test (Test for 75 biomarkers including yeast & bacterial gut overgrowth, as well as vitamin levels) - - - > Thyroid + Adrenal + Hormone Test  (Discover your complete thyroid, adrenal, hormone, vitamin D & insulin levels) - - - > Adrenal + Hormone Test (Run your adrenal & hormone levels) - - - > Food Sensitivity Test (Find out your hidden food sensitivities) - - - > Omega-3 Test (Discover your levels of inflammation related to your omega-6 to omega-3 levels) - - - > Stool Test (Use this test to uncover any bacterial, h. Pylori, or parasite overgrowth) - - - > Genetic Test (Use the #1 lab test to unlocking your DNA and what it means in terms of wellness, weight loss & anti-aging) - - - > Dr. Cabral’s “Big 5” Lab Tests (This package includes the 5 labs Dr. Cabral recommends all people run in his private practice) - - - > View all Functional Medicine lab tests (View all Functional Medicine lab tests you can do right at home for you and your family!)  

The future of medicine is really the past of medicine. I know that sounds pretty deep... but hear me out. We have records that at least two thousand years ago, physicians were prescribing medicinal mushrooms to their patients. Viral infection, headache, low libido… you name it. Medicinal mushrooms ranked at the top of the list in effectiveness for most illnesses. Now, here’s the rub. They also prescribed them to patients to help keep from being sick in the first place (not just when they had a problem). It’s a very different model today, where our healthcare practitioners profit only when you are sick. Contrast that with the practitioner of old, who was paid to keep you well. One of these approaches needs more sick people around. The other one is single-focused on doing what it takes to keep you healthy. The irony is that today’s physician is unknowingly prescribing drugs from fungi too. A sizeable percentage of the top pharmaceutical drugs are derived from mushrooms and other fungi (you’ve heard of penicillin, right?). They have been studied and used because they work. The problem with the pharmaceutical model, however, is the rampant occurrence of side effects. They’re obviously not using the thing found in nature as practitioners did in the past. Instead, they isolate, isolate, isolate until it’s just a shadow of its former self (and shadows can be pretty creepy as it is). Today we’re going to look at exactly why medicinal mushrooms are so effective that Big Pharma loves them. But, more importantly, we’ll be diving in on the very best mushrooms to utilize to keep you healthy in the first place… without side effects (unless you count being more awesome as a side effect). Tero Isokauppila is back on the show to blow your mind with practical tips, clinically proven data, and even a recipe for chocolate mousse that can help protect you from the common cold and more. Click play, take good notes, and enjoy! In this episode you'll discover: Why exercise benefits several areas of our lives. The surprising amount of pharmaceutical drugs that utilize fungi. How mushrooms and human DNA are related. What immunomodulation means. Why some substances can act like caffeine for your immune system. What natural killer cells are and how medicinal mushrooms train them. How a food or herb can be classified as an adaptogen. Which medicinal mushroom is amazing for your skin. How medicinal mushrooms are able to create vitamin D like humans do. Which mushroom is best for stress reduction and clinically proven to improve sleep. What the "three treasures" are in Chinese medicine. Which medicinal mushroom features the potent anticancer compound PSK. Why mushrooms are the original worldwide web. Why some mushrooms are actually great for fighting fungal infections. Which mushroom has been found to be effective for supporting weight loss. Whether or not medicinal mushrooms are safe for kids and pregnant mothers. How your respiratory system can be protected with a specific mushroom. Whether or not you should be using medicinal mushrooms on a daily basis. Items mentioned in this episode include: Foursigmatic.com/model ⇐ Get 15% off your daily health elixirs and coffee! Organifi.com ⇐ Use the coupon code model for 20% off The Secret Life Of Your Immune System - Episode 166 Everyday Medicines & The World’s Healthiest Coffee - Tero Isokauppila - Episode 191 Natural Flu Prevention - Episode 29 The Fat Loss Masterclass Replay ⇐ Only available for a limited time! * Download The Transcript Thank you so much for checking out this episode of The Model Health Show. If you haven’t done so already, please take a minute and leave a quick rating and review of the show on Apple Podcasts by clicking on the link below. It will help us to keep delivering life-changing information for you every week! Click Here to Subscribe via Apple Podcasts Click Here to Subscribe via Stitcher Click here to Subscribe via Spotify Click here to Subscribe via Soundcloud

Vincent, Elio, Michael, and Michelle review how a pathogen promotes plant attractiveness to insect vectors, and activation of sensory neurons that modulate pain and inflammation by bacterial infection.  

Steve Perrin PhD, CEO and CSO of ALS TDI, talks Gilenya, other emerging immunomodulators and their potential to treat ALS going forward. Read more: http://blogs.als.net/post/2013/02/12/Gilenya-giving-ALS-the-fingo.aspx

Robert Miller MD, Director of California Pacific Medical Center’s Forbes Norris MDA/ALS Research and Treatment Center, talks NP001 and its potential to treat ALS going forward. Read more: http://blogs.als.net/post/2012/12/17/NP001-a-quiet-riot-in-ALS.aspx

Mon, 11 Jul 2011 12:00:00 +0100 https://edoc.ub.uni-muenchen.de/13445/ https://edoc.ub.uni-muenchen.de/13445/1/Edelmann_Stephanie.pdf Edelmann, Stephanie ddc:610, dd

Due to growing shortage of donor organs, the concept of extracorporeal pig liver perfusion in the treatment of acute liver failure has been rediscovered. Immunomodulation, such as immunoapheresis or inhibition of complement, results in long-term perfusion without exact knowledge of the remaining metabolic graft viability. This study was aimed at the comparison of conventional parameters of graft stability such as perfusion rates and release of aminotransferases with parameters of metabolic graft function. Ig-Therasorb(R) immunoapheresis (IA) of the xenogeneic perfusate was performed to protect the discordant pig livers from hyperacute rejection, mediated by preformed naturally occurring human xenogeneic antibodies. The application of IA created stable autologous graft reperfusion after a short time of xenoperfusion, but it was not able to prevent the livers from severe synthetic and functional damage. In the future, improvement of xenogeneic graft function, rather than pure prolongation of perfusion, must be the principal aim.