Podcasts about danon

À l'occasion de la journée internationale des personnes handicapées, nous parlons de leur santé mentale. Il s'agit non seulement de favoriser le bien-être des personnes en situation de handicap, mais également de mieux diagnostiquer et prendre en charge certaines comorbidités psychiques. Les affections mentales constituent en effet une comorbidité fréquente et parfois négligée, tant pour les personnes affectées dans leur mobilité par un handicap physique que pour les personnes concernées par un trouble moteur.  La santé mentale, grande cause nationale en France pour 2025, est reconduite pour l'année 2026. Les obstacles à la santé mentale sont multiples : qu'il s'agisse de l'accès aux soignants formés et spécialisés, les freins d'ordre financiers, géographiques, auxquels s'ajoutent les préjugés ou les fake-news, qui exposent les personnes à des retards de prise en charge ou à des traitements inappropriés. Les entraves et inégalités dans cet accès aux soins psychologiques et psychiatriques sont encore plus présentes pour certaines populations vulnérables. Aujourd'hui, à l'occasion de la journée internationale des personnes handicapées, Priorité Santé évoque les besoins et obstacles spécifiques qui concernent leur santé mentale, qu'ils ou elles soient porteur.es d'un handicap physique ou moteur.  Le double fardeau du handicap et de la santé mentale  Pour les personnes en situation de handicap, la détresse psychologique peut être générée par des émotions associées au handicap lui-même : angoisse d'être stigmatisé, isolé, exclu tout comme la difficulté de le dire. Des facteurs spécifiques peuvent également intervenir, comme la gestion de la douleur, la détresse affective et sexuelle, la frustration associée au manque d'autonomie.   À côté des problématiques liées directement ou handicap, peuvent se développer également des comorbidités d'ordre psychique et/ou psychiatrique ; avec un risque de sous-diagnostic, et donc d'absence de prise en charge, susceptible d'amplifier les symptômes et d'accroître le fardeau de la maladie et d'amplifier leur sévérité.  Valoriser la différence et les compétences   L'enjeu de la santé mentale dans le parcours de soins des personnes en situation de handicap doit donc être valorisé et considéré en fonction des spécificités des parcours de chacune et de chacun, des émotions individuelles, mais aussi des compétences propres aux personnes en situation de handicap. Mieux comprendre, mieux prendre en charge, lutter contre la stigmatisation, pour rendre le soin réellement accessible à tous les publics.  Avec : Matteo Bussoletti, psychologue, psychothérapeute, exerce au sein d'un IEM (Institut d'Éducation Motrice) dans la région du Havre, accueillant des enfants et des adolescents avec une déficience motrice et des troubles associés. Il est l'auteur de plusieurs articles sur des problématiques émotionnelles, scolaires et développementales de l'enfant et de l'adolescent. Ses travaux portent également sur les pratiques d'accompagnement psychologique, notamment l'hypnose, qu'il a intégrée à la prise en charge des jeunes en situation de handicap Hortense Aka Dago-Akribi, psychologue clinicienne et professeure titulaire à l'Université Félix Houphouët Boigny de Cocody à Abidjan en Côte d'Ivoire.   Un reportage de Charlie Dupiot. ► En fin d'émission, nous parlons du Téléthon qui se tient les 5 et 6 décembre 2025 en France. À quelques jours de ce rendez-vous dédié à la recherche contre les maladies génétiques, coup de projecteur sur le projet européen DREAMS, un projet pour améliorer la prise en charge de cinq maladies rares : la myopathie de Duchenne, une myopathie centronucléaire, la myopathie d'Emery-Dreifuss, la maladie de Pompe et la maladie de Danon. Interview de Xavier Nissan, directeur de recherche à I-Stem et coordonnateur du projet Dreams.   Programmation musicale : ► Nathi feat. Kayla Carrington – A vida é minha ► Natanjo – Kimia.

À l'occasion de la journée internationale des personnes handicapées, nous parlons de leur santé mentale. Il s'agit non seulement de favoriser le bien-être des personnes en situation de handicap, mais également de mieux diagnostiquer et prendre en charge certaines comorbidités psychiques. Les affections mentales constituent en effet une comorbidité fréquente et parfois négligée, tant pour les personnes affectées dans leur mobilité par un handicap physique que pour les personnes concernées par un trouble moteur.  La santé mentale, grande cause nationale en France pour 2025, est reconduite pour l'année 2026. Les obstacles à la santé mentale sont multiples : qu'il s'agisse de l'accès aux soignants formés et spécialisés, les freins d'ordre financiers, géographiques, auxquels s'ajoutent les préjugés ou les fake-news, qui exposent les personnes à des retards de prise en charge ou à des traitements inappropriés. Les entraves et inégalités dans cet accès aux soins psychologiques et psychiatriques sont encore plus présentes pour certaines populations vulnérables. Aujourd'hui, à l'occasion de la journée internationale des personnes handicapées, Priorité Santé évoque les besoins et obstacles spécifiques qui concernent leur santé mentale, qu'ils ou elles soient porteur.es d'un handicap physique ou moteur.  Le double fardeau du handicap et de la santé mentale  Pour les personnes en situation de handicap, la détresse psychologique peut être générée par des émotions associées au handicap lui-même : angoisse d'être stigmatisé, isolé, exclu tout comme la difficulté de le dire. Des facteurs spécifiques peuvent également intervenir, comme la gestion de la douleur, la détresse affective et sexuelle, la frustration associée au manque d'autonomie.   À côté des problématiques liées directement ou handicap, peuvent se développer également des comorbidités d'ordre psychique et/ou psychiatrique ; avec un risque de sous-diagnostic, et donc d'absence de prise en charge, susceptible d'amplifier les symptômes et d'accroître le fardeau de la maladie et d'amplifier leur sévérité.  Valoriser la différence et les compétences   L'enjeu de la santé mentale dans le parcours de soins des personnes en situation de handicap doit donc être valorisé et considéré en fonction des spécificités des parcours de chacune et de chacun, des émotions individuelles, mais aussi des compétences propres aux personnes en situation de handicap. Mieux comprendre, mieux prendre en charge, lutter contre la stigmatisation, pour rendre le soin réellement accessible à tous les publics.  Avec : Matteo Bussoletti, psychologue, psychothérapeute, exerce au sein d'un IEM (Institut d'Éducation Motrice) dans la région du Havre, accueillant des enfants et des adolescents avec une déficience motrice et des troubles associés. Il est l'auteur de plusieurs articles sur des problématiques émotionnelles, scolaires et développementales de l'enfant et de l'adolescent. Ses travaux portent également sur les pratiques d'accompagnement psychologique, notamment l'hypnose, qu'il a intégrée à la prise en charge des jeunes en situation de handicap Hortense Aka Dago-Akribi, psychologue clinicienne et professeure titulaire à l'Université Félix Houphouët Boigny de Cocody à Abidjan en Côte d'Ivoire.   Un reportage de Charlie Dupiot. ► En fin d'émission, nous parlons du Téléthon qui se tient les 5 et 6 décembre 2025 en France. À quelques jours de ce rendez-vous dédié à la recherche contre les maladies génétiques, coup de projecteur sur le projet européen DREAMS, un projet pour améliorer la prise en charge de cinq maladies rares : la myopathie de Duchenne, une myopathie centronucléaire, la myopathie d'Emery-Dreifuss, la maladie de Pompe et la maladie de Danon. Interview de Xavier Nissan, directeur de recherche à I-Stem et coordonnateur du projet Dreams.   Programmation musicale : ► Nathi feat. Kayla Carrington – A vida é minha ► Natanjo – Kimia.

In this week's episode, I rate the movies and streaming shows I saw in Autumn 2025. This coupon code will get you 25% off the ebooks in The Ghosts series at my Payhip store: GHOSTS2025 The coupon code is valid through December 1, 2025. So if you need a new ebook this fall, we've got you covered! TRANSCRIPT 00:00:00 Introduction and Writing Updates Hello, everyone. Welcome to Episode 278 of The Pulp Writer Show. My name is Jonathan Moeller. Today is November 21st, 2025, and today I am sharing my reviews of the movies and streaming shows I saw in Fall 2025. We also have a Coupon of the Week and an update my current writing, audiobook, and publishing projects. So let's start off with Coupon of the Week. This week's coupon code will get you 25% off all the ebooks in The Ghosts series at my Payhip store, and that is GHOSTS2025. And as always, we'll have the link to my Payhip store and the coupon code in the show notes for this episode. This coupon code is valid through December 1, 2025, so if you need a new ebook for this fall, we have got you covered. Now for my current writing and publishing projects: I'm very pleased to report that Blade of Shadows, the second book in my Blades of Ruin epic fantasy series, is now out. You can get it at Amazon, Barnes and Noble, Kobo, Google Play, Apple Books, Smashwords, and my Payhip store. By the time this episode goes live, all those stores should be available and you can get the book at any one of them and I hope you will read and enjoy it. I'm also 15,000 words into what will be my next main project Wizard-Assassin, the fifth book in the Half-Elven Thief series, and if all goes well, I want that to be out before Christmas. I'm also working on the outline for what will be the third book in the Blades of Ruin series, Blade of Storms, and that will hopefully, if all goes well, be the first book I publish in 2026. In audiobook news, as I mentioned last week, the audiobook of Blade of Flames is done and I believe as of this recording, you can get at my Payhip store, Google Play, Kobo, and I think Spotify. It's not up on Audible or Apple yet, but that should be soon, if all goes well. That is excellently narrated by Brad Wills. Hollis McCarthy is still working on Cloak of Embers. I believe main recording is done for that and it just has to be edited and proofed, so hopefully we'll get both audiobooks to you before the end of the year. So that is where I'm at with my current writing, publishing, and audiobook projects. 00:02:08 Main Topic of the Week: Autumn 2025 Movie Review Roundup Now on to this week's main project, the Autumn 2025 Movie Review Roundup. I watched a lot of classic horror movies this time around. The old Universal black and white monster movies from the '30s and '40s turned up on Prime for Halloween and I hadn't seen them since I was a kid, so I watched a bunch of them in October and November, which seemed an appropriate thing to do for Halloween. They mostly held up as well as I remembered from when I was a kid, which was a nice surprise. As ever, the grades I give these movies are totally subjective and based on nothing more than my own opinions and thoughts. With that, let's take a look at the movies from least favorite to most favorite. First up is The Other Guys, which came out in 2010 and this is a parody of the buddy cop/ cowboy cop movie along with a heavy critique of the reckless and corrupt culture of late 2000s Wall Street. "Dumb funny" movies I've noticed tend to fall on either side of the "dumb but actually funny" or "dumb and not funny" line. And this one definitely landed on "dumb but actually funny". Danson and Highsmith, played by The Rock and Samuel L. Jackson, are two maverick popular detectives who never do paperwork. Their paperwork is always done by Allen Gamble, who's played by Will Ferrell and Terry Hoitz, played by Mark Wahlberg. Gamble is a mild-mannered forensic accountant, while Hoitz desperately wants to be as cool as either Danson or Highsmith, but since he accidentally shot Yankees player Derek Jeter (in a recurring gag), he's a pariah within the New York Police Department. However, Danon and Highsmith's plot armor suddenly run out and they accidentally kill themselves in a darkly hilarious scene that made me laugh so much I hurt a little. Hoitz wants to step into their shoes, but Gamble has stumbled onto potentially dangerous case and soon Hoitz and Gamble have to overcome their difficulties and unravel a complicated financial crime. This was pretty funny and I enjoyed it. Amusingly in real life, someone like Gamble would be massively respected in whatever law enforcement agency he works for, since someone who prepares ironclad paperwork and correct documentation that stands up in court is an invaluable asset in law enforcement work. Overall Grade: B Next up is Fantastic Four: First Steps, which came out in 2025. I like this though, to be honest, I liked Thunderbolts and Superman 2025 better. I think my difficulty is I never really understood The Fantastic Four as a concept and why they're appealing. Maybe the Fantastic Four are one of those things you just have to imprint on when you're a kid to really enjoy or maybe at my age, the sort of retro futurism of the Four, the idea that science, technology, and rational thought will solve all our problems does seem a bit naive after the last 65 years of history or so. Additionally, the idea of a naked silver space alien riding a surfboard does seem kind of ridiculous. Anyway, the movie glides over the origin story of Reed Richards, Sue Storm, Johnny Storm, and Ben Grimm and gets right into it. To their surprise, Reed and Sue find out that Sue is pregnant, which seemed unlikely due to their superpower induced genetic mutations. Shortly after that, the Silver Surfer arrives and announces that Earth will be devoured by Galactus. The Four travel in their spaceship to confront Galactus and realize that he's a foe far beyond their power, but Galactus offers them a bargain. If Reed and Sue give him their son, he will leave Earth in peace. They refuse and so it's up to the Four to figure out a way to save Earth and Reed and Sue's son. Pretty solid superhero movie all told, but it is amusing how in every version of the character, Reed Richards is allegedly the smartest man on Earth but still can't keep his mouth shut to save his life. Overall Grade: B The next movie is Superman, which came out in 1978. After seeing the 2025 version of Superman, I decided to watch the old one from the '70s. It's kind of a classic because it was one of the progenitors of the modern superhero film. Interestingly, it was one of the most expensive films ever made at that time, costing about $55 million in '70s-era dollars, which are much less inflated than today. A rough back of the envelope calculation would put 55 million in the '70s worth at about $272 million today, give or take. Anyway, this was a big gamble, but it paid off for the producers since they got $300 million back, which would be like around $1.4 billion in 2025 money. Anyway, the movie tells the origin story of Superman, how his father Jor-El knows that Krypton is doomed, so he sends Kal-El to Earth. Kal-El is raised as Clark Kent by his adoptive Kansas parents and uses his powers to become Superman- defender of truth, justice, and the American way. Superman must balance his growing feelings for ace reporter Lois Lane with his need for a secret identity and the necessity of stopping Lex Luthor's dangerous schemes. Christopher Reeve was an excellent Superman and the special effects were impressive by the standards of 1978, but I think the weakest part of the movie were the villains. Lex Luthor just seemed comedic and not at all that threatening. Unexpected fun fact: Mario Puzio, author of The Godfather, wrote the screenplay. Overall Grade: B Next up is Superman II, which came out in 1980. This is a direct sequel to the previous movie. When Superman stops terrorists from detonating a nuclear bomb by throwing it into space, the blast releases the evil Kryptonian General Zod and his minions from their prison and they decide to conquer Earth. Meanwhile, Superman is falling deeper in love with the Lois Lane and unknowing of the threat from Zod, decides to renounce his powers to live with Lois as an ordinary man. I think this had the same strengths and weaknesses as the first movie. Christopher Reeve was an excellent Superman. The special effects were impressive by the standards of the 1980s, but the villains remained kind of comedic goofballs. Additionally, and while this will sound harsh, this version of Lois Lane was kind of dumb and her main function in the plot was to generate problems for Superman via her questionable decisions. Like at the end, Superman has to wipe her memory because she can't keep his secret identity to herself. If this version of Lois Lane lived today, she'd be oversharing everything she ever thought or heard on TikTok. The 2025 movie version of Lois, by contrast, bullies Mr. Terrific into lending her his flying saucer so she can rescue Superman when he's in trouble and is instrumental in destroying Lex Luthor's public image and triggering his downfall. 1970s Louis would've just had a meltdown and made things worse until Superman could get around to rescuing her. Overall, I would say the 1978 movie was too goofy, the Zac Snyder Superman movies were too grimdark, but the 2025 Superman hit the right balance between goofy and serious. Overall Grade: B Next up is Dracula, which came out in 1931, and this was one of the earliest horror movies ever made and also one of the earliest movies ever produced with sound. It is a very compressed adaptation of the stage version of Dracula. Imagine the theatrical stage version of Dracula, but then imagine that the movie was only 70 minutes long, so you have to cut a lot to fit the story into those 70 minutes. So if you haven't read the book, Dracula the movie from 1931 will not make a lot of sense. It's almost like the "Cliff's Notes Fast Run" version of Dracula. That said, Bela Lugosi's famous performance as Dracula really carries the movie. Like Boris Karloff in Frankenstein and The Mummy (which we'll talk about shortly), Bela Lugosi really captures the uncanny valley aspect of Dracula because the count isn't human anymore and has all these little tics of a creature that isn't human but only pretending to be one. Edward Van Sloan's performance as Dr. Van Helsing is likewise good and helped define the character in the public eye. So worth watching as a historical artifact, but I think some of the other Universal monster movies (which we'll discuss shortly) are much stronger. Overall Grade: B Next up is The Horror of Dracula, which came out in 1958. This is one of the first of the Hammer Horror movies from the '50s, starring Peter Cushing as Dr. Van Helsing and Christopher Lee as Count Dracula. It's also apparently the first vampire movie ever made in color. Like the 1931 version of Dracula, it's a condensed version of the story, though frankly, I think it hangs together a little better. Van Helsing is a bit more of an action hero in this one, since in the end he engages Dracula in fisticuffs. The movie is essentially carried by the charisma of Peter Cushing and Christopher Lee and worth watching as a good example of a classic '50s horror movie. Overall Grade: B Next up is The Wolf Man, which came out in 1941. This is another one of the classic Universal horror movies. This one features Lon Cheney Jr. as Larry Talbot, the younger son of Sir John Talbot. Larry's older brother died in a hunting accident, so Larry comes home to reconcile with his father and take up his duties as the family heir. Larry is kind of an amiable Average Joe and is immediately smitten with the prettiest girl in the village, but when he takes her out for a walk, they're attacked by a werewolf, who bites Larry. Larry and everyone else in the village do not believe in werewolves, but they're about to have their minds changed the hard way. The transformation sequences where Larry turns into the Wolfman were cutting edge of the time, though poor Lon Chaney Jr had to stay motionless for hours as they gradually glued yak hair to him. I think Claude Rains had the best performance in the movie as Sir John and he's almost the co-protagonist. Overall Grade: B Next up is Jurassic World: Rebirth, which came out in 2025, which I thought was a perfectly straightforward but nonetheless enjoyable adventure film. After all the many disasters caused by various genetic engineering experiments in the previous movies, dinosaurs mostly live in relatively compatible ecosystems and tropical zones near the equator. No one's looking to create a theme park with dinosaurs or create bioengineered dinosaurs as military assets any longer. However, the dinosaurs are still valuable for research and a pharmaceutical company is developing a revolutionary drug for treating cardiac disease. They just need some dinosaur blood from three of the largest species to finish it, and so the company hires a team of mercenaries to retrieve the blood. We have the usual Jurassic Park style story tropes: the savvy mercenary leader, the scientist protesting the ethics of it all, the sinister corporate executive, the troubled family getting sucked into the chaos. And of course, it all goes wrong and there are lots and lots of dinosaurs running around. It's all been done before of course, but this was done well and was entertaining. Overall Grade: B+ Next up is The Thursday Murder Club, which came out in 2025, and this is a cozy mystery set in a very high-end retirement home. Retired nurse Joyce moves into Coopers Chase, the aforementioned high end retirement home. Looking to make new friends, she falls in with a former MI6 agent named Liz, a retired trade unionist named Ron, and psychiatrist Ibrahim, who have what they call The Thursday Murder Club, where they look into cold cases and attempt to solve them. However, things are not all sunshine and light at Coopers Chase as the two owners of the building have fallen out. When one of them is murdered, The Thursday Murder Club has to solve a real murder before Coopers Chase is bulldozed to make high-end apartments. A good cozy mystery with high caliber acting talent. Both Pierce Brosnan and Jonathan Price are in the movie and regrettably do not share a scene together, because that would've been hilarious since they were both in the James Bond movie Tomorrow Never Dies in the '90s with Brosnan as Bond and Price as the Bond villain for the movie. Overall Grade: B+ Next up is The Creature From the Black Lagoon, which came out in 1954 and is one of the last of the black and white classic horror movies since in the '50s, color film was just around the corner. When a scientist finds the unusual half fish, half human fossil on a riverbank in Brazil, he decides to organize an expedition upriver to see if he can find the rest of the fossil. The trail leads his expedition to the mysterious Black Lagoon, which all the locals avoid because of its bad reputation, but a living member of the species that produce the fossils lurking the lagoon while it normally doesn't welcome visitors, it does like the one female member of the expedition and decides to claim her for its own. The creature was good monster and the underwater water sequences were impressive by the standards of the 1950s. Overall Grade: A- Next up is The Invisible Man, which came out in 1933, and this is another of the classic Universal black and white horror movies. Jack Griffin is a scientist who discovered a chemical formula for invisibility. Unfortunately, one of the drugs in his formula causes homicidal insanity, so he becomes a megalomaniac who wants to use his invisibility to rule the world. This causes Griffin to overlook the numerous weaknesses of his invisibility, which allow the police to hunt him down. The Invisible Man's special effects were state of the art at the time and definitely hold up nearly a hundred years later. It's worth watching as another classic of the genre. Claude Rains plays Griffin, and as with The Wolf Man, his performance as Griffin descends into homicidal insanity is one of the strengths of the movie. Overall Grade: A- Next up is The Mummy, which came out in 1932, and this is another of the original Universal black and white horror movies. Boris Karloff plays the Mummy, who is the ancient Egyptian priest Imhotep, who was mummified alive for the crime of desiring the Pharaoh's daughter Ankh-es-en-Amon. After 3,000 years, Imhotep is accidentally brought back to life when an archeologist reads a magical spell and Imhotep sets out immediately to find the reincarnation of his beloved and transform her into a mummy as well so they can live together forever as undead. Edward Van Sloan plays Dr. Mueller, who is basically Edward Van Sloan's Van Helsing from Dracula if Van Helsing specialized in mummy hunting rather than vampire hunting. This version of the Mummy acts more like a Dungeons and Dragons lich instead of the now classic image of a shambling mummy in dragging bandages. That said, Boris Karloff is an excellent physical actor. As he does with Frankenstein, he brings Imhotep to life. His performance captures the essence of a creature that hasn't been human for a very long time, is trying to pretend to be human, and isn't quite getting there. Of course, the plot was reused for the 1999 version of The Mummy with Brendan Fraser. That was excellent and this is as well. Overall Grade: A- Next up is The Wedding Singer, which came out in 1998, and this is basically the Adam Sandler version of a Hallmark movie. Adam Sandler plays Robbie, a formerly famous musician whose career has lapsed and has become a wedding singer and a venue singer. He befriends the new waitress Julia at the venue, played by Drew Barrymore. The day after that, Robbie's abandoned at the altar by his fiancée, which is understandably devastating. Meanwhile, Julia's fiancé Glenn proposes to her and Robbie agrees to help her with the wedding planning since he's an expert in the area and knows all the local vendors. However, in the process, Robbie and Julia fall in love, but are in denial about the fact, a situation made more tense when Robbie realizes Glenn is cheating on Julia and intends to continue to do so after the wedding. So it's basically a Hallmark movie filtered through the comedic sensibilities of Adam Sandler. It was very funny and Steve Buscemi always does great side characters in Adam Sandler movies. Overall Grade: A Next up is Downton Abbey: The Grand Finale, which came out in 2025. This movie was sort of a self-indulgent victory lap, but it was earned. The writers of the sitcom Community used to joke that they wanted "six seasons and a movie" and Downton Abbey got "six seasons and three movies". Anyway, this movie is about handing off things to the next generation. Lord Grantham is reluctant to fully retire as his daughter goes through a scandal related to her divorce. The next generation of servants take over as the previous ones ease into retirement. What's interesting is both the nobles and the servants are fully aware that they're sort of LARPing a historical relic by this point because by 1930, grand country houses like Downton were increasingly rare in the UK since World War I wiped out most of them and crippling post-war taxes and economic disruption finished off many more. Anyway, if you like Downton Abbey, you like this movie. Overall Grade: A Next up is Argo, which came out in 2012, a very tense thriller about the Iranian hostage crisis in 1979. During that particular crisis, six Americans escaped the embassy and hid out at the Canadian Ambassador's house in Tehran. For obvious reasons, the Canadian ambassador wanted them out as quickly as possible, so the CIA and the State Department needed to cook up a plan to get the six out while the rest of the government tried to figure out what to do about the larger group of hostages. Finally, the government comes with "Argo." A CIA operative will create a fake film crew, a fake film company, and smuggle the six out of Tehran as part of the production. The movie was very tense and very well constructed, even if you know the outcome in advance if you know a little bit of history. Ben Affleck directed and starred, and this was in my opinion one of his best performances. It did take some liberties with historical accuracy, but nonetheless, a very tense political thriller/heist movie with some moments of very dark comedy. Overall Grade: A Next up is The Naked Gun, which came out in 2025, and this is a pitch perfect parody of the gritty cop movie with a lot of absurdist humor, which works well because Liam Neeson brings his grim action persona to the movie and it works really well with the comedy. Neeson plays Lieutenant Frank Drebin Jr., the son of the original Frank Drebin from The Naked Gun movies back in the '80s. After stopping a bank robbery, Drebin finds himself investigating the suicide of an engineer for the sinister tech mogul Richard Cane. Naturally, the suicide isn't what it appears and when the engineer's mysterious but seductive sister asks for Drebin's help, he pushes deeper into the case. Richard Cane was a hilarious villain because the writers couldn't decide which tech billionaire to parody with him, so they kind of parodied all the tech billionaires at once, and I kid you not, the original Frank Drebin makes an appearance as a magical owl. It was hilarious. Overall Grade: A Now for my two favorite things I saw in Autumn 2025. The first is the combination of Frankenstein and Bride of Frankenstein, which came out in 1931 and 1935. These are two separate movies, but Frankenstein leads directly to Bride of Frankenstein, so I'm going to treat them as one movie. Honestly, I think they're two halves of the same story the way that Avengers: Infinity War and Avengers: Endgame would be two halves of the same story 90 years later, so I'll review them as one. Frankenstein by itself on its own will get a B. Colin Clive's performance is Dr. Henry Frankenstein was great, and Boris Karloff gives the Creature a suitable air of menace and uncanny valley. You really feel like he's something that's been brought to life but isn't quite right and still extremely dangerous. The movie does have a very pat ending that implies everyone will live happily ever after, with Dr. Frankenstein's father giving a toast to his son. But Bride of Frankenstein takes everything from the first movie and improves on it. It's one of those sequels that actually makes the preceding movie better. In Bride, Henry is recovering from his ordeal and swears off his experiments of trying to create artificial humans, but the Creature survived the fire at the windmill at the end of the last movie and is seeking for a new purpose. Meanwhile, Henry receives a visit from his previous mentor, the sinister Dr. Pretorius. Like Henry, Pretorius succeeded in creating artificial life and now he wants to work with Henry to perfect their work, but Henry refuses, horrified by the consequences of his previous experiments. Pretorius, undaunted, makes an alliance with the Creature, who then kidnaps Henry's wife. This will let Pretorius force Henry to work on their ultimate work together-a bride for the Creature. Bride of Frankenstein is a lot tighter than Frankenstein. It was surprising to see how rapidly filmmaking techniques evolved over just four years. Pretorius is an excellent villain, more evil wizard than mad scientist, and the scene where he calmly and effortlessly persuades the Creature to his side was excellent. One amusing note, Bride was framed as Mary Shelley telling the second half of the story to her friends, and then the actress playing Mary Shelley, Elsa Lancaster, also played the Bride. So that was a funny bit of meta humor. Frankenstein and Bride of Frankenstein combined is one of my two favorite movies of Fall 2025. Overall Grade: A+ And now for my second favorite movie of Autumn 2025, which as it turns out is also Frankenstein, but Guillermo del Toro's version that came out in 2025. And honestly, I think Guillermo del Toro's version of Frankenstein is the best version put to screen so far and even does the rarest of all feats, it improves a little on the original novel. Oscar Isaac plays Victor Frankenstein as a brilliant, driven scientist with something of a sociopathic edge. In other words, he's a man who's utterly inadequate to the task when his experiment succeeds and he actually creates an artificial human that have assembled dead body parts. Jacob Elordi does a good job as the Creature, playing him is essentially a good hearted man who's driven to violence and despair by the cruelty and rejection of the world. The recurring question of the Frankenstein mythos is whether or not Victor Frankenstein is the real monster. In this version, he definitely is, though he gets a chance to repent of his evil by the end. Honestly, everything about this was good. The performances, the cinematography, everything. How good was it? It was so good that I will waive my usual one grade penalty for unnecessary nudity since there were a few brief scenes of it. Overall Grade: A+ So that was the Autumn 2025 Movie Roundup. A lot of good movies this time around. While some movies of course were better than others, I didn't see anything I actively disliked, which is always nice. So that's it for this week. Thanks for listening to The Pulp Writer Show. I hope you found the show useful. A reminder that you can listen to all the back episodes at https://thepulpwritershow.com. If you enjoyed the podcast, please leave your review on your podcasting platform of choice. Stay safe and stay healthy and see you all next week.  

David Danon is an athlete, author, yogi, wellness and fitness coach who specializes in helping people pursue health and fitness for Optimal Aging through Food, Fitness, and Fun! David had a powerful wake-up call after a brutal job and a cancer diagnosis sidetracked his dreams. His book is titled "Life, Yoga, and Cancer: Lessons from the Battlefield," which is available on Amazon. He is passionate about helping people, especially those over 40, age with strength, mobility, metabolic health, and well-being for life! David firmly believes that we can all but the myths of aging, be an inspiration for others, and help make the world a happier, healthier, and better place. David shares his remarkable story as well as important insights, tips, and valuable information to inspire and motivate an entire population of people over 40 to live the healthy, vibrant, and active life they were meant to live. Download this positive, uplifting, and informative episode and discover how we can all enjoy optimal aging, for life!      Connect with David: https://daviddanon.com/ https://www.facebook.com/david.danon.5 https://www.youtube.com/@danonyogaandfitness4591 https://www.instagram.com/danonyoga/ https://www.linkedin.com/in/david-danon-261518126/

I recently sat down with Israeli Ambassador to the United Nations Danny Danon at the Republican Jewish Coalition (RJC) Summit, where leaders gathered to reaffirm their commitment to Israel and confront the disturbing rise of anti-Israel and antisemitic sentiment creeping into parts of the conservative right. In this powerful interview, Ambassador Danon shares his insights on Israel's fight against Hamas in Gaza, the challenges at the UN, and the battle against growing Jew-hating antisemitism.Join Our Whatsapp Channel: https://chat.whatsapp.com/GkavRznXy731nxxRyptCMvFollow us on Twitter: https://x.com/AviAbelowJoin our Telegram Channel: https://t.me/aviabelowpulseFollow us on Instagram: https://www.instagram.com/pulse_of_israel/?hl=enPulse of Israel on Facebook: https://www.facebook.com/IsraelVideoNetworkVisit Our Website - https://pulseofisrael.com/Donate to Pulse of Israel: https://pulseofisrael.com/boost-this-video/

Psychologist and heart-transplant recipient Dr. Brittany Clayborne shares how her own medical journey prepared her to guide her son Micah through sudden heart failure, an LVAD, and a life-saving transplant. She unpacks the family's rare Danon's disease diagnosis, post-transplant cancer (PTLD), and the everyday realities after transplant—meds, setbacks, and hope. You'll learn Dr. Brittany's BRAVE framework for hard moments, how rituals sustain connection during long hospital stays, and how Micah turned his experience into action with Transplant Teens and My Brave Journal. This conversation is packed with concrete tools, compassion, and the reminder that “hope is a team sport.” You do not want to miss this week's episode. Featured moments: 00:00 — Why families need “somewhere to be brave.” 04:50 — Brittany's peripartum cardiomyopathy, ICU wait, and LVAD. 10:05 — PTLD diagnosis and becoming the psychologist she needed. 12:50 — Micah's chest pain → HCM crisis and transplant path. 24:00 — The BRAVE acronym families can use today. 44:00 — “Hope is a team sport.” Transplant Teens' vision. Key takeaways: Use BRAVE in tough conversations: Breathe • Realize feelings • Accept them • Vent/Vulnerable with a trusted person • Elevate above it. Build predictable touchpoints (calls/visits) to anchor kids during long hospitalizations. Teens heal better with peers; if the group doesn't exist yet, create it. Resources mentioned: Transplant Teens (free peer support for grades 7–12) Transplant Teens Instagram My Brave Journal (and transplant edition) by Micah — on Amazon. Contact Dr. Brittany: @DrBrittanySpeaks; offers limited free virtual sessions with referrals for ongoing care.

Nous nous intéressons au plan pour Gaza présenté lundi par le président américain Donald Trump au Hamas comme une proposition à prendre ou à laisser pour mettre fin à une guerre qui a fait plus de 66 000 morts. Un plan qui laisse une infinité de questions sans réponses sur l'avenir politique et sécuritaire de l'enclave comme celui d'Israël mais aussi sur celui de la Cisjordanie. Un plan – accompagné d'une myriade de superlatifs dans la bouche du président américain – qui vient se confronter au réel. Que dit ce réel ? Questions posées à Éric Danon, ancien ambassadeur de France en Israël, Ofer Bronchtein, président et co-fondateur du Forum International pour la Paix et Armin Arefi, grand reporter au Point et spécialiste du Moyen-Orient.

  Life after work doesn't come with a roadmap. But my guest today shows what can happen when you stay curious and keep saying “yes.”   David Danon has worn many hats: sailor, hair stylist, yoga teacher, Hollywood crew member, and musician. Now, in his seventies, he continues to surf, foil, and coach others on healthy aging. His journey is proof that reinvention can happen at any age.   In this episode, David shares:   How sailing and surfing shaped his outlook on life Why curiosity has opened unexpected doors throughout his journey The lessons yoga and meditation taught him about resilience and peace Why vigilance and resolve are essential for healthy aging The importance of creating purpose beyond career identity   Resources: Visit David's website Self-Realization Fellowship

Invités :  - Eric Danon, ancien ambassadeur de France en Israël (2019-2023) - Ian Brossat, sénateur communiste de Paris et candidat à la Mairie de Paris Chroniqueurs :  - Raphaël Stainville, directeur adjoint de la rédaction du JDD - Jules Torres, journaliste politique au JDD - Gilles Boutin, journaliste en politique économique au Figaro - Nathan Devers, écrivain et essayiste Hébergé par Audiomeans. Visitez audiomeans.fr/politique-de-confidentialite pour plus d'informations.

In this powerful episode of Walk In Victory, host NaRon Tillman welcomes health and wellness expert David Danon for a deeply insightful dialogue on how yoga, breathwork, and mindfulness can dramatically improve physical and mental well-being—especially for those over 45. David shares his journey from early yoga experiences to becoming a teacher committed to helping clients unlock greater mobility, flexibility, and strength as they age.Together, they explore: ✅ The role of yoga in reducing pain and inflammation✅ Breathing techniques that support nervous system regulation✅ Why resistance training matters for longevity✅ The spiritual benefits of daily movement and presence✅ The connection between discipline and freedomThis episode is more than a health talk—it's a roadmap for cultivating vibrant aging, overcoming mental and physical limitations, and aligning your body with your higher purpose. 

What happens when the world's watching—and judging—your every move? Israeli Ambassador to the United Nations, Danny Danon, sits down with Dr. Phil to break down Israel's war objectives, the moral tightrope of civilian protection, and the global firestorm of criticism. From accusations of genocide to the rise of antisemitism on college campuses, Danon doesn't hold back. He shares what it takes to lead under pressure, why media narratives matter, and how international aid can fuel the very terror it's meant to stop. If you care about truth, leadership, and what's really at stake in the Middle East, this is a conversation you won't want to miss.  HostagesInGaza #IsraelWarStrategy #MilitaryObjectives #HumanitarianAid  #CivilianProtection #GazaCrisis Subscribe | Rate | Review | Share:YouTube: https://bit.ly/3H3lJ8n Apple Podcasts: https://apple.co/4jVk6rX Spotify: https://bit.ly/4n6PCVZ Website: https://www.drphilpodcast.com This episode is brought to you by Home Title Lock: Go to https://hometitlelock.com/drphil  and use promo code PHIL to get a FREE title history report and a FREE TRIAL of their Triple Lock Protection! For details visit https://hometitlelock.com/warranty This episode is brought to you by Beam: Visit https://shopbeam.com/DRPHIL and use code DRPHIL to get an exclusive discount of up to 40% off!      

Special In Wheel Time Replay - What happens when childhood dreams of muscle cars finally come true? Danon Hollinger joins us at the Lone Star Street Rod Association's 50th anniversary celebration to share her journey from Hot Rod magazine fan to proud owner of a gleaming white 1978 Pontiac Trans Am.Unlike most girls growing up, Danon decorated her headboard with car magazine centerfolds instead of pop stars. Her fascinating story takes us from her early fascination with a high school crush's '69 Camaro to discovering something unexpected—a Trans Am with a poignant backstory. The previous owner had lovingly restored it for his son who, after a tragic accident, could never drive it. Now this beautiful machine has found new life with an owner who truly appreciates its power and presence.The conversation takes a few detours through Danon's unique name (from an old Western film), her career as a teacher now enjoying retirement, and the modifications they've made to transform their Trans Am from drag racer to comfortable cruiser. Their upgrade to a Tremec five-speed transmission highlights the perfect balance they've struck between preserving vintage character and enhancing drivability.We also explore the joy of car club culture as Danon shares adventures with her Houston-based Great Classics club—from "margarita meetings" to cross-country trips to shows in Reno and along the Mississippi coast. Her enthusiasm for decorating the Trans Am for Christmas parades and local charity events showcases how classic cars become more than possessions—they're vehicles for building community and creating lasting memories.Later, Jeff presents his Car Culture segment featuring the best US cities for vintage car shows, from Detroit's Woodward Dream Cruise to the elegance of Pebble Beach. Tune in for a heartwarming reminder that automotive passion knows no boundaries—and sometimes the perfect car finds you when you least expect it.Be sure to subscribe for more In Wheel Time Car Talk! Gulf Coast Auto ShieldPaint protection, tint, and more!The Lupe' Tortilla RestaurantsLupe Tortilla in Katy, TexasDisclaimer: This post contains affiliate links. If you make a purchase, I may receive a commission at no extra cost to you.---- ----- Want more In Wheel Time car talk any time? In Wheel Time is now available on Audacy! Just go to Audacy.com/InWheelTime where ever you are.----- -----Be sure to subscribe on your favorite podcast provider for the next episode of In Wheel Time Podcast and check out our live multiplatform broadcast every Saturday, 10a - 12noonCT simulcasting on Audacy, YouTube, Facebook, Twitter, Twitch and InWheelTime.com.In Wheel Time Podcast can be heard on you mobile device from providers such as:Apple Podcasts, Amazon Music Podcast, Spotify, SiriusXM Podcast, iHeartRadio podcast, TuneIn + Alexa, Podcast Addict, Castro, Castbox, YouTube Podcast and more on your mobile device.Follow InWheelTime.com for the latest updates!Twitter: https://twitter.com/InWheelTimeInstagram: https://www.instagram.com/inwheeltime/https://www.youtube.com/inwheeltimehttps://www.Facebook.com/InWheelTimeFor more information about In Wheel Time Car Talk, email us at info@inwheeltime.comTags: In Wheel Time, automotive car talk show, car talk, Live car talk show, In Wheel Time Car Talk

History is made as Markus Schulz presents the first-ever Global DJ Broadcast World Tour recorded live from Vietnam - captured at the vibrant Ciné nightclub in Saigon. A landmark night for the series and the Vietnamese dance music scene, this set delivers an unforgettable journey across dark techno, melodic trance, and signature Down the Rabbit Hole energy.   Central to the night is the spotlight premiere of Monolith - Markus Schulz's powerful new collaboration with Frankyeffe, releasing this Friday. A 140 BPM fusion of techno intensity and trance emotion, Monolith is a peak-time highlight and centerpiece of the set.   An immersive, genre-blending experience direct from the dancefloor - this is a World Tour moment to remember.   Markus Schulz (Recorded Live from Ciné in Saigon, Vietnam - July 5 2025) 01. Kay D. Smith & Marc Tall - Hoipolloi (Ben Gold Remix) 02. Zhu - Faded (HNTR Edit) 03. Joy Orbinson - Flight FM (Danny Avila Remix) 04. Anyma, Argy & Son of Son - Voices in My Head 05. Markus Schulz - The New World (ID Remix) 06. Robert Nickson - Heliopause (ID Remix) 07. Mark Sixma, Orjan Nilsen, Push & nilsix vs. Layton Giordani, Sarah de Warren & Linney - Act of Urban Shakedown (Markus Schulz Down the Rabbit Hole Mashup) 08. Tiesto & Arkham Knights vs. Belocca - Traffic Metamorphis (Markus Schulz Down the Rabbit Hole Mashup) 09. Markus Schulz & Jochen Miller - Rotunda (Dave Neven Remix) 10. Cristoph - I Will Find You (Charles D Remix) 11. Mike EFEX - Monsters 12. ID - Superstring 13. Markus Schulz x Pavlo Vicci - Get You Higher 14. Markus Schulz x Frankyeffe - Monolith 15. Markus Schulz and Departure with Gabriel & Dresden - Without You Near (Fisherman Remix) 16. HNTR - Victory 17. Gabry Ponte & Jerome Isma-Ae vs. Stylo, Space Motion & Amethyst - Walk Aone, Sucker (Markus Schulz Down the Rabbit Hole Mashup) 18. JOA - Everyday 19. Ummet Ozcan - The Box (Markus Schulz Big Room Reconstruction) 20. Mark Dekoda vs. Bart Skils & Layton Giordani - Rave Harder Valentine (Markus Schulz Down the Rabbit Hole Mashup) 21. Markus Schulz - Remember This (Dream Sequence Remix) 22. BLR, Matt Sassari & Truetone - Submerge 23. ALAT - Theurgia Page 110 24. Massano - Fama Land 25. SMACK featuring Sarah de Warren - C'est la Vie 26. Push - Universal Nation (Daxson Remix) 27. Matt Fax - Axis 28. Mark Reeve & Joyhauser - Focus (Markus Schulz Down the Rabbit Hole Reconstruction) 29. Dirty Vegas - Days Go By (NOMADsignal Remix) 30. Sander van Doorn & Laura van Dam - My Mind (Instrumental Mix) 31. RÜFÜS DU SOL - On My Knees (Cassian Remix) 32. Pig&Dan - On a Train (KhoMha Edit) 33. Kaufmann - Have You Turned Off the Oven 34. Max Styler & Oscar L - Addiction  

Eric Danon, ancien ambassadeur de France en Israël, était l'invité de la matinale de Radio Classique ce lundi 30 juin. Il est revenu sur la manière qu'a Donald Trump, président américain, «d'imposer la paix», et sur sa légitimé à recevoir le prix Nobel de la paix. Mention légales : Vos données de connexion, dont votre adresse IP, sont traités par Radio Classique, responsable de traitement, sur la base de son intérêt légitime, par l'intermédiaire de son sous-traitant Ausha, à des fins de réalisation de statistiques agréées et de lutte contre la fraude. Ces données sont supprimées en temps réel pour la finalité statistique et sous cinq mois à compter de la collecte à des fins de lutte contre la fraude. Pour plus d'informations sur les traitements réalisés par Radio Classique et exercer vos droits, consultez notre Politique de confidentialité.Hébergé par Ausha. Visitez ausha.co/politique-de-confidentialite pour plus d'informations.

Cette semaine, Laurent Neumann reçoit Éric Danon, ancien ambassadeur de France en Israël, pour tout comprendre de la « guerre de douze jours » entre Israël et l'Iran.Qu'est-ce qu'une attaque préventive ? Que vaut le cessez-le-feu proposé par Donald Trump ? Le droit international peut-il encore réguler les rapports entre États ? Toutes les réponses dans Quid Juris.Bonne écoute ! Hébergé par Acast. Visitez acast.com/privacy pour plus d'informations.

When classic car lovers gather, stories flow as freely as chrome gleams in the Texas sun. From the Lone Star Street Rod Association's 50th Anniversary celebration in Granbury, we discover the human connections behind these metal masterpieces.Meet Danon Hollinger, who grew up with hot rod magazine fold-outs on her bedroom headboard instead of pop stars. Her gorgeous white 1978 Pontiac Trans Am represents a lifelong dream fulfilled. After years of waiting, she found this beauty through a car club connection – a vehicle with its own poignant history, having been restored for a son who suffered an accident and could no longer drive it. Danon and her husband transformed it with a Tremec five-speed transmission to keep pace with their Houston-area car club on cruises across the country.Then there's Larry Davidson's showstopping 1960 Ford Ranch Wagon – a chrome-laden masterpiece in striking blue. Originally purchased on eBay while searching for something completely different, Larry explains how station wagons have transformed from demolition derby fodder to highly sought-after collectibles. His ingenious restoration touches include chromed freeze plugs repurposed as decorative "gun sights" on the fenders, demonstrating the creativity that defines true car enthusiasts.Beyond the vehicles themselves, we explore what makes Granbury worth the drive – from the historic Acton State Historical Site where Davy Crockett's wife Elizabeth is buried to the nostalgic Brazos Drive-In Theater operating since 1952. We round out with automotive headlines including the return of the Hemi V8 to Ram's pickup lineup.Whether you're a dedicated gearhead or simply appreciate the stories behind beautiful machines, these conversations capture the passion, ingenuity, and community that make car culture so enduring. Join us for more automotive adventures every Saturday morning on Facebook, YouTube, and InWheelTime.com.Be sure to subscribe for more In Wheel Time Car Talk!---- ----- Want more In Wheel Time car talk any time? In Wheel Time is now available on Audacy! Just go to Audacy.com/InWheelTime where ever you are.----- -----Be sure to subscribe on your favorite podcast provider for the next episode of In Wheel Time Podcast and check out our live multiplatform broadcast every Saturday, 10a - 12noonCT simulcasting on Audacy, YouTube, Facebook, Twitter, Twitch and InWheelTime.com.In Wheel Time Podcast can be heard on you mobile device from providers such as:Apple Podcasts, Amazon Music Podcast, Spotify, SiriusXM Podcast, iHeartRadio podcast, TuneIn + Alexa, Podcast Addict, Castro, Castbox, YouTube Podcast and more on your mobile device.Follow InWheelTime.com for the latest updates!Twitter: https://twitter.com/InWheelTimeInstagram: https://www.instagram.com/inwheeltime/https://www.youtube.com/inwheeltimehttps://www.Facebook.com/InWheelTimeFor more information about In Wheel Time Car Talk, email us at info@inwheeltime.comTags: In Wheel Time, automotive car talk show, car talk, Live car talk show, In Wheel Time Car Talk

Distribué par Audiomeans. Visitez audiomeans.fr/politique-de-confidentialite pour plus d'informations.

Danny Danon, Israel's Ambassador to the United Nations, says the attacks against Iran will continue. Danon says the goal is to eliminate Iran's nuclear capability and to stop Iran from producing ballistic missiles. He says Iran was preparing to attack Israel again with missiles and Israel could not let that happen. Danon spoke with Bloomberg's Jonathan Ferro and Annmarie Hordern.See omnystudio.com/listener for privacy information.

L'ancien ambassadeur de France en Israël Eric Danon, invité de la matinale est revenu sur l'attaque israélienne visant les sites nucléaires iraniens. Il estime que l'intensité des combats va durer « environ une semaine »Mention légales : Vos données de connexion, dont votre adresse IP, sont traités par Radio Classique, responsable de traitement, sur la base de son intérêt légitime, par l'intermédiaire de son sous-traitant Ausha, à des fins de réalisation de statistiques agréées et de lutte contre la fraude. Ces données sont supprimées en temps réel pour la finalité statistique et sous cinq mois à compter de la collecte à des fins de lutte contre la fraude. Pour plus d'informations sur les traitements réalisés par Radio Classique et exercer vos droits, consultez notre Politique de confidentialité.Hébergé par Ausha. Visitez ausha.co/politique-de-confidentialite pour plus d'informations.

A gene therapy clinical trial for Danon disease run by Rocket Pharmaceuticals has been suspended following the death of a patient. MIT and Recursion have released Boltz-2, an open-source tool that predicts molecular binding affinity at newfound speed and accuracy, aiming to democratize commercial drug discovery. Intellia Therapeutics saw its stock nosedive late last week after a patient in its Phase III trial of the CRISPR-based therapy experienced non-lethal liver toxicity. In other news, a therapeutic plasma exchange regimen combined with intravenous immunoglobulin reduced some biomarkers of biological age in humans. Sanofi has agreed to acquire Blueprint Medicines for up to $9.5 billion, and a universal CAR T cell therapy was produced by applying CRISPR gene editing to cells donated by healthy individuals. Join GEN editors Corinna Singleman, PhD, Alex Philippidis, Fay Lin, PhD, and Uduak Thomas for a discussion of the latest biotech and biopharma news.  Listed below are links to the GEN stories referenced in this episode of Touching Base Danon Disease Patient Dies in Rocket Gene Therapy Trial By Alex Philippidis, GEN, May 27, 2025 Boltz-2 Released to Democratize AI Molecular Modeling for Drug Discovery By Fay Lin, PhD, GENEdge, June 6, 2025 StockWatch: Intellia Stumbles on News of Patient's Severe Liver Toxicity By Alex Philippidis, GEN, May 30, 2025 The State of CRISPR Summit Registration https://bit.ly/CRISPR25 Plasma Exchange in Humans Reduces Biological Age by Over Two Years GEN, June 1, 2025 Sanofi to Acquire Blueprint Medicines for Up to $9.5B By Alex Philippidis, GEN Edge, June 2, 2025 "Universal" CAR-T Immunotherapy Targets Relapsed/Refractory Blood Cancers GEN, May 30, 2025 Hosted on Acast. See acast.com/privacy for more information.

Good morning from Pharma and Biotech daily: the podcast that gives you only what's important to hear in Pharma and Biotech world.Former Chinook board member, Rouzbeh Haghighat, has been indicted for insider trading related to Novartis' $3.2 billion acquisition of the company. Despite this scandal, pharma R&D spending increased in 2024, climbing 1.5% across the global pharmaceutical sector. The acquisition of SiteOne by Lilly follows Vertex into the non-opioid pain space, providing diversification for Lilly, which has been focusing on obesity and diabetes treatments. Meanwhile, AbbVie's Allergan cuts over 200 staff after a botched marketing campaign, and Inflarx axes a rare skin disease study due to disappointing late-stage data.AGC Biologics will be at Bio International in Boston to showcase their global capabilities in drug production. Vaccine overhaul, rocket grounding, and drug price transparency are also highlighted in the latest news. Biogen's strategy for Zurzuvae shifts as obstetricians/gynecologists rise to the front lines. Drug price transparency in the US is discussed as being easier said than done. Additionally, Rocket's gene therapy for Danon disease is on hold after a patient death, and four biotechs are facing uncertainty in the COVID-19 vaccine landscape.Global pharmaceutical companies are increasing their research and development spending despite political and economic challenges. Biogen is shifting its strategy for the drug Zurzuvae as obstetricians and gynecologists become more involved. Drug price transparency in the US is still a challenge, despite efforts to increase transparency. Trilink has introduced a new poly(A) tail modification to enhance protein expression.In other news, a former Chinook board member has been indicted for insider trading, Trump has appointed Dr. Oz to lead drug pricing negotiations, and Lilly is following Vertex into non-opioid pain treatment with a SiteOne acquisition. Sanofi has purchased Vigil for $470 million to reignite an Alzheimer's target.

Distribué par Audiomeans. Visitez audiomeans.fr/politique-de-confidentialite pour plus d'informations.

Good morning from Pharma and Biotech Daily: the podcast that gives you only what's important to hear in Pharma and Biotech world.A patient death has led to the halt of Rocket's gene therapy trial for Danon disease, due to complications from an acute systemic infection. This incident highlights the unpredictable nature of gene therapies and may pose challenges for investment in the field. On the other hand, mRNA technology has been both helped and hindered by the COVID-19 pandemic. While the pandemic has increased interest and funding in mRNA research, vocal skeptics of COVID-19 vaccinations have negatively impacted the reputation of mRNA technology. Despite this, some see promise in mRNA for therapeutics in cancer and rare diseases.In other news, Prothena is considering business options after a failed phase III trial, and a new biotech company has been launched to focus on neuro diseases. Additionally, AGC Biologics will be at Bio International to showcase their capabilities in protein biologics and advanced therapies.mRNA technology played a significant role in combating COVID-19, but is now facing scrutiny due to vaccine skeptics and cuts in government funding for research. Despite this, the pandemic accelerated advancements in mRNA therapeutics for cancer and rare diseases. The lack of FDA-approved treatments for rare diseases, particularly in children, highlights a critical need for innovation in this area. The American Association for Cancer Research's annual conference will unveil data that could impact cancer treatment, while the future of vaccine development faces challenges amidst regulatory changes and funding issues. Additionally, advancements in cell and gene therapy are on the horizon. Suggestions for coverage topics in the biopharma industry are welcomed.

The name of the biopharma game this season is vaccines—and RFK Jr. wasted no time returning from Memorial Day Weekend before making news on this front, removing the COVID-19 vaccine from the list of recommended immunizations for healthy kids and pregnant women on Tuesday. This follows a rash of recent moves, including a new risk-based strategy for the approval of new COVID vaccines focused on adults over 65 and high-risk individuals six months to 64 years of age and a request that Moderna and partners Pfizer and BioNTech update the myocarditis risk on their vaccines' labels.This increased vaccine scrutiny by the FDA and Department of Health and Human Services is having a significant impact on biopharma companies, several of whom have received stop-work orders on next-gen COVID vaccines. Meanwhile, Moderna last week pulled the biological license application for its combination COVID-19/flu vaccine, anticipating a request for additional data on flu shot efficacy from the FDA, as mRNA technology continues to be scrutinized after playing the hero during the pandemic. Also last week, the White House released its Make America Healthy Again (MAHA) report, which took aim at vaccines, along with pharma lobbying and GLP-1s.Also on the policy front, a California judge issued an order Thursday that indefinitely stops HHS' goal of reducing its divisions from 28 to 15 and firing upwards of 10,000 employees, among other reorganization and mass layoff plans. And speaking of government plays that could receive judicial pushback, we received a couple of new updates on the Most Favored Nation (MFN) front: first, President Donald Trump appointed his CMS chief Mehmet Oz as the leader of drug pricing negotiations, calling him “one tough hombre,” and second, HHS provided new guidance for streamlining the process for states to import drugs from Canada.In the obesity realm, Eli Lilly is calling out the Centers for Medicare and Medicaid Services. In an open letter last week, Lilly voiced its displeasure with the agency for a final ruling that left its Zepbound and Novo Nordisk's Wegovy out of Medicare Advantage and Part D coverage in 2026.And in the R&D realm, we returned from the long weekend to sad news from Rocket Pharmaceuticals, as the company reported that its pivotal Danon disease trial is on hold after the death of a young patient. The death—extremely sad on a human level—is also a setback for the gene therapy space, which had been buoyed earlier this month by the success of a personalized CRISPR treatment received by baby KJ.Finally, BioSpace looks ahead to ASCO#25 where Dan Samorodnitsky will be on the ground in Chicago.

Une audience particulièrement houleuse s'est tenue ce mardi 8 avril 2025 devant la Cour suprême israélienne, symbole des tensions politiques dans le pays. Les recours contre le limogeage du chef de l'Agence de la sécurité intérieure (Shin Bet), Ronen Bar, étaient examinés. Cette décision est dénoncée par ses détracteurs comme une dérive autocratique du pouvoir. Tout comme le vote à l'unanimité, fin mars, d'une motion de défiance inédite contre la procureure générale Gali Baharav-Miara. Dans le contexte de l'offensive à Gaza et de la colonisation en Cisjordanie, Israël constitue-t-il encore une démocratie ? Qu'est-ce qui pourrait stopper le Premier ministre Benyamin Netanyahu ?Pour en débattre Sylvaine Bulle, sociologue, chercheuse à l'École des hautes études en sciences sociales), autrice du livre Sociologie de Jérusalem (Éditions de La Découverte, 2020) Rina Bassist, correspondante de la radio israélienne à Paris et rédactrice au journal Al-Monitor Éric Danon, ambassadeur de France en Israël de 2019 à 2023À lire aussiIsraël: Benyamin Netanyahu mis en cause pour «conflit d'intérêts» pour le renvoi du chef du Shin Bet

Une audience particulièrement houleuse s'est tenue ce mardi 8 avril 2025 devant la Cour suprême israélienne, symbole des tensions politiques dans le pays. Les recours contre le limogeage du chef de l'Agence de la sécurité intérieure (Shin Bet), Ronen Bar, étaient examinés. Cette décision est dénoncée par ses détracteurs comme une dérive autocratique du pouvoir. Tout comme le vote à l'unanimité, fin mars, d'une motion de défiance inédite contre la procureure générale Gali Baharav-Miara. Dans le contexte de l'offensive à Gaza et de la colonisation en Cisjordanie, Israël constitue-t-il encore une démocratie ? Qu'est-ce qui pourrait stopper le Premier ministre Benyamin Netanyahu ?Pour en débattre Sylvaine Bulle, sociologue, chercheuse à l'École des hautes études en sciences sociales), autrice du livre Sociologie de Jérusalem (Éditions de La Découverte, 2020) Rina Bassist, correspondante de la radio israélienne à Paris et rédactrice au journal Al-Monitor Éric Danon, ambassadeur de France en Israël de 2019 à 2023À lire aussiIsraël: Benyamin Netanyahu mis en cause pour «conflit d'intérêts» pour le renvoi du chef du Shin Bet

Featuring articles on bacterial vaginosis, diabetes prevention, Danon disease, chronic spontaneous urticaria, and VITT-like monoclonal gammopathy of thrombotic significance; a review article on micronutrients; a Clinical Problem-Solving on unveiling the unforeseen; and Perspectives on bankruptcy and genetic information, on drug development for rare diseases, on facing political attacks on medical education, and on sustaining equity efforts in the face of regression.

Sam Danon, the managing partner at Hunton Andrews Kurth, talks about the importance of firm culture, what associates want out of a law firm and how building his litigation practice helped him establish credibility as a manager. 

Tous les samedis et dimanches, dans Europe 1 Matin week-end, Alexandre Devecchio, rédacteur en chef du service débats du Figaro, livre son édito.

Tous les samedis et dimanches, dans Europe 1 Matin week-end, Alexandre Devecchio, rédacteur en chef du service débats du Figaro, livre son édito.

Die Israeliese ambassadeur na die VN, Danny Danon, sê hy kan glad nie verstaan waaroor daar ‘n bohaai is oor die verskuiwing van Palestyne uit Gaza sodat president Donald Trump dit kan omskep in die Riviera van die Midde-Ooste nie. Hy het met SkyNews gepraat en sê as mense wil trek moet hulle kan.

Summary:  This week on The Genetics Podcast, Patrick is joined by Eric Adler, Chief Medical Officer and Head of Research at Lexeo Therapeutics and Professor of Medicine at University of California San Diego. Eric shares his experience with genetic cardiomyopathy and his work on gene therapy for Danon disease, drawing from both clinical and research perspectives. Additionally, he explores the evolution of the field and the broader challenges faced by cardiovascular patients. Show Notes:  0:00 Intro to The Genetics Podcast 01:00 Welcome to Eric and his efforts in cardiomyopathy at the bench and bedside 03:32 How modeling genetic diseases using pluripotent stem cells lead Eric to studying Danon disease  04:50 Pivoting from basic to translational research using adeno-associated viruses (AAV)-based gene therapy 07:58 Uncovering genetic cardiomyopathies that were misdiagnosed as idiopathic cardiomyopathy 09:55 Treatment, screening, and penetrance of Danon disease 12:30 Recent successes and remaining challenges in cardiovascular disease 19:47 Battling distrust in the medical profession 21:55 Preventative therapy using APOE2 for patients at risk of early Alzheimer's   25:15 Motivations behind and advantages of Eric's patient-centered approach to therapeutics 27:24 Balancing regulatory requirements for protocols versus patient needs 29:49 The importance of committed clinical partners for successful trial execution 36:08 Eric's passion for cooking and how he won a cooking competition 39:02 Closing remarks and Lexeo Therapeutics' aims for 2025 Find out more Lexeo Therapeutics (https://www.lexeotx.com/) Please consider rating and reviewing us on your chosen podcast listening platform!  https://drive.google.com/file/d/1Bp2_wVNSzntTs_zuoizU8bX1dvao4jfj/view?usp=share_link

El veto de Israel a las operaciones de la agencia de la ONU para los refugiados palestinos (UNRWA) ha elevado la tensión y preocupación internacional. En octubre, el Parlamento israelí aprobó dos leyes que ordenaban la salida de esa agencia del territorio y de Jerusalén Este. En la práctica, la medida limita casi totalmente su operación en Gaza y Cisjordania, porque la ayuda solo entra con el aval de los israelíes. El martes 28 de enero, el embajador de Israel ante la ONU, Danny Danon, dio 48 horas a la agencia de la ONU para los refugiados palestinos (UNRWA) para evacuar sus centros en Jerusalén, en cumplimiento de una ley israelí que prohíbe al organismo prestar servicios en territorio israelí.Israel ha señalado a la UNRWA de mantener vínculos con el grupo palestino islamista Hamás."UNRWA deberá cesar sus operaciones y evacuar todos los locales en los que opera en Jerusalén, incluidas las propiedades situadas en Ma'alot Dafna (en Jerusalén Este) y Kfar Aqueb", dijo Danon en el marco de una sesión del Consejo de Seguridad, en el que se trató la situación de la agencia.El embajador citó la ley aprobada en octubre pasado que prohíbe a la UNRWA prestar servicios en territorio israelí, incluido el este de Jerusalén, donde viven más de 300.000 palestinos.Leer también¿Qué implicaciones tiene para los palestinos la prohibición de operaciones de la UNRWA en Israel?El inminente cese de operaciones de la UNRWA, este 30 de enero, ha disparado las alarmas en la región y de la comunidad internacional porque esta agencia, que cuenta con unos 30.000 empleados, se encarga de algunos servicios básicos, como los sanitarios  y educativos, a los palestinos desplazados tras la creación del Estado de Israel y a sus descendientes, tanto en Gaza y Cisjordania como en Líbano, Siria y Jordania.Creada por la Asamblea General de las Naciones Unidas en 1949, la agencia de la ONU gestiona centros de salud y escuelas en la Franja de Gaza y Cisjordania. Proporciona refugio, alimentos y atención sanitaria y se considera la "columna vertebral" de la ayuda en Gaza.La situación llevó a convocar dos reuniones de urgencia del Consejo de Seguridad de la ONU para discutir el tema.Israel insiste en que la UNRWA se tiene que ir, mientras que la agencia reitera que esto atenta contra la obligación que tiene el Estado israelí con el Derecho Internacional y que solo la Asamblea General de Naciones Unidas puede decidir sobre su mandato.En tanto, el secretario general de la ONU, António Guterres, en una respuesta a Danon, advirtió el martes  que Israel "no tiene derecho a ejercer poderes soberanos en ninguna parte del Territorio Palestino Ocupado, incluyendo el este de Jerusalén", y que su presencia allí es "ilegal" según el Corte Internacional de Justicia.Y añadió que no hay organización capaz de sustituir a la UNRWA, justo cuando está involucrada en la implementación del alto el fuego entre Israel y Hamás, que incluye la liberación de rehenes israelíes y la entrada de ayuda humanitaria en Gaza.Leer también¿Qué impacto tiene el retiro de la UNRWA en la atención humanitaria para Gaza y Jerusalén?¿Cómo afectará el cierre de UNRWA la entrega de ayuda humanitaria para los palestinos y el cese al fuego en Gaza? ¿Se trata de una decisión soberana de Israel que debe ser respetada? Para analizar el tema, participan en El Debate dos invitados.- Desde Barcelona, Cristina Muñoz, directora de Alianza por la Solidaridad, una ONG española que trabaja en Gaza.- Desde Costa Rica, Jesús Aguirre Gorgona, Máster en Derechos Humanos e Historia Judía y profesor de Política Global e Historia Hebrea en el Instituto Doctor Jaim Weizman.

On Friday's Mark Levin Show, President Biden can't leave the office quick enough. He now claims to have amended the Constitution. Biden announced that the Equal Rights Amendment is the “law of the land,” despite the Justice Department and the U.S. archivist saying the President could not ratify the Constitutional amendment. Biden is lawless then he lectures us about the rule of law. According to Democrats, you can do anything if it's in pursuit of the radical left agenda. Also, Ambassador Danny Danon calls in to discuss the Israel/Hamas ceasefire. This is not a peace agreement; Israel keeps the right to go into Gaza and finish off Hamas if necessary. Danon says they are determined to finish the job but will pause to get the hostages back.  Later, Democrats keep telling us we have to fix our immigration laws, but they're not broken.  We have very detailed immigration laws which work if they are enforced. The problem is Democrats lack of virtue and lack of execution - its intentional.  It will be important to have a Governor in the DHS position – Kristi Noem will be fantastic. Afterward, a unanimous Supreme Court upheld the TikTok ban. It can still survive; it just needs new American ownership. We can't allow China to control Americans' data. Learn more about your ad choices. Visit podcastchoices.com/adchoices

For review:1. US CENTCOM Forces Strike Houthi Rebel Targets.On Dec. 30 and 31, US Navy ships and aircraft targeted a Houthi command and control facility and advanced conventional weapon (ACW) production and storage facilities that included missiles and uncrewed aerial vehicles (UAVs). 2. Israeli Ambassador (Danny Danon) to UN Gives Last Warning to Houthis. “To the Houthis, perhaps you have not been paying attention to what has happened to the Middle East over the past year. Well, allow me to remind you what has happened to Hamas, to Hezbollah, to Assad, to all those who have attempted to destroy us. Let this be your final warning,” Danon told the UN Security Council. 3. Latest in Israel - Hamas Hostage Negotiations. Israel & Hamas disagree on number of living Hostages to be released.4. Latest US Security Assistance Package to Ukraine worth $1.25 Billion.In addition, the US Treasury Department meanwhile announced the disbursement of $3.4 billion in direct budgetary support for Ukraine. 5. Greece to provide 24 x Sea Sparrow Missiles to Ukraine. The missiles are part of a broader defense package for Ukraine, including artillery shells, weaponry, and ammunition.6. Russian Foreign Minister (Sergei Lavrov) on President-elect Trump Peace proposal: “Of course, we are not satisfied with the proposals being voiced by representatives of the president-elect to postpone Ukrainian NATO membership for 20 years and to send to Ukraine a peacekeeping contingent of ‘British and European forces,'” Lavrov said. 7. Turkish Drone Maker Baykar purchases Italian aviation firm Piaggio Aerospace. 

CardioNerds (Dr. Dan Ambinder and guest host, Dr. Pooja Prasad) join Dr. Donny Mattia from Phoenix Children's pediatric cardiology fellowship, Dr. Sri Nayak from the Mayo Clinic – Arizona adult cardiology fellowship, and Dr. Harrison VanDolah from the University of Arizona College of Medicine - Phoenix Med/Peds program for a sunrise hike of Piestewa Peak, followed by some coffee at Berdena's in Old Town Scottsdale (before the bachelorette parties arrive), then finally a stroll through the Phoenix Desert Botanical Gardens to discuss a thought-provoking case series full of clinical cardiology pearls. Expert commentary is provided by Dr. Tabitha Moe. Episode audio was edited by Dan Ambinder. They discuss the following case: Cardiology is consulted by the OB team for a 27-year-old female G1, now P1, who has just delivered a healthy baby boy at 34 weeks gestation after going into premature labor. She is experiencing shortness of breath and is found to have a significant past cardiac history, including atrial fibrillation and preexcitation, now with a pacemaker and intracardiac defibrillator. We review the differential diagnosis for peripartum cardiomyopathy (PPCM) and then combine findings from her infant son, who is seen by our pediatric cardiology colleagues and is found to have severe hypertrophic cardiomyopathy (HCM). Genetic testing for both ultimately reveals a LAMP2 mutation consistent with Danon Disease. The case discussion focuses on the differential diagnosis for PPCM, HCM, pearls on Danon Disease and other HCM “phenocopies,” and the importance of good history. US Cardiology Review is now the official journal of CardioNerds! Submit your manuscript here. CardioNerds Case Reports PageCardioNerds Episode PageCardioNerds AcademyCardionerds Healy Honor Roll CardioNerds Journal ClubSubscribe to The Heartbeat Newsletter!Check out CardioNerds SWAG!Become a CardioNerds Patron! Case Media Pearls Peripartum cardiomyopathy is a diagnosis of exclusion – we must exclude other possible etiologies of heart failure! Be on the lookout for features of non-sarcomeric HCM – as Dr. Michelle Kittleson said in Episode 166, “LVH plus” states. HCM with preexcitation, heart block, strong family history, or extracardiac symptoms such as peripheral neuropathy, myopathy, or cognitive impairment should be evaluated for infiltrative/inherited cardiomyopathies! As an X-linked dominant disorder, Danon disease will present differently in males vs females, with males having much more severe and earlier onset disease with extracardiac features. Making the diagnosis for genetic disorders such as Danon disease is important for getting the rest of family members tested as well as the opportunity for specialized treatments such as gene therapy Up to 5% of Danon disease cases may be due to copy number variants, which may be missed in genetic testing that does not do targeted deletion/duplication analysis!). Notes What is the differential diagnosis for peripartum cardiomyopathy? Peripartum cardiomyopathy is a diagnosis of exclusion – we must exclude other possible etiologies of heart failure! First, ensure that you are not missing an acute life-threatening etiology of acute decompensated heart failure – pulmonary embolism, amniotic fluid embolism, ACS, and SCAD should all be ruled out. Second, a careful history can identify underlying heart disease or risk factors for the development of heart failure, such as substance use, high-risk behaviors that put one at risk for HIV infection, and family history that suggests an inheritable cardiomyopathy. Lastly, a careful review of echocardiographic imaging may also identify underlying etiologies that warrant a change in management. Diagnosis of peripartum cardiomyopathy is important to consider as within 7 days of onset, patients may be eligible for treatment with bromocriptine – consider referring ...

Did you miss AHA 2024? Listen here to brief discussions of the latest research. Eric Rubin is the Editor-in-Chief of the Journal. Jane Leopold is a Deputy Editor of the Journal. Stephen Morrissey, the interviewer, is the Executive Managing Editor of the Journal. E.J. Rubin, J. Leopold, and S. Morrissey. NEJM at AHA — Phase 1 Study of AAV9.LAMP2B Gene Therapy in Danon Disease. N Engl J Med. DOI: 10.1056/NEJMe2414477.

Today, we're thrilled to bring you one of the most anticipated episodes of the year with Anthony Danon about the official announcement of Rerail, his brand-new $20M angel fund. You ofc already know Anthony as one of the hosts of our SuperAngel podcast series and part of the powerful duo behind Cocoa together with Carmen

20Angel is a series profiling European angel investors with the best Founder NPS. Episode 19 features Anthony Danon, Founder of Rerail, the latest Solo GP Fund to enter the European ecosytem. Anthony has spent 10 years in fintech as an operator, VC and angel, having done 35+ investments, with a portfolio including, Primer, TrueLayer, Wayflyer and many more. And on Monday 14th October, he announced Rerail I, an angel fund backed and supported by founders and operators. He invests $200k-$500k checks at pre-seed/seed into founders looking to utilize fintech as a strategic advantage, with a skew to Europe, but globally. The format for 20Angel is consistent across show, with questions including: What are some of the non-obvious things they look for when investing in a company? How they work with their Founders? What they think makes a great angel investor? Show links: https://www.rerail.vc/ https://www.linkedin.com/in/anthony-danon-3409099b/

L'acteur, décédé à l'âge de 88 ans, sera inhumé ce samedi 24 août. Géraldine Danon sera présente aux obsèques.

Ecoutez RTL Matin avec Stéphane Boudsocq du 19 août 2024.

Géraldine Danon invitée de Stéphane Boudscoq et les nombreuses réactions à la disparition d'Alain Delon. Sans oublier les hommages rendus sur les chaînes de télévision.

Linda shared her amazing journey from being a Lawyer and hating it to now helping others understand the power of the mind. Linda is an RTT practitioner, life coach and trainer in the power of the mind and thoughts, she helps people get from where they are to where they want to be. She is very passionate about the workings of the subconscious mind and the brain as well as our ability, as human beings, to create the life that we want. And so while Linda creates the life of her dreams, she is helping others do the same.

Ruth Danon grew up on the grounds of a mental hospital where her mother was a psychiatrist and many neighbors were European immigrants fleeing the devastation of World War 2. She forged a winding literary path, publishing four poetry collections and developing a style of teaching that treats writing as a studio art. She moved to Beacon in 2020 and now teaches privately and curates literary events such as the Spring Street Reading Series at Atlas Studios in Newburh and the Beacon Lit Fest,  In this interview Ruth talks about her life and reads a cluster of poems from her new collection, “Turn up the Heat.”  Photo credit: Meredith Heuer 

Hi Friends,This episode Jess and I discuss resolutions with friends of the podcast Leslie and Danon.  They share their unique perspectives on New Year Resolutions. We all discuss if we agree with them, how effective are they and how we hold ourselves accountable.   There were a few gems I personally got from this conversation.  I hope you do as well. Enjoy.. Happy New Year!email: Bambooearringspod@gmail.comIG @ PodcastbambooearringsPhone 313 744 2087 (Leave a message)

CardioNerds cofounder Dr. Amit Goyal and cardiology fellows from the Cleveland Clinic (Drs. Alejandro Duran Crane, Gary Parizher, and Simrat Kaur) discuss the following case: A 61-year-old man presented with symptoms of heart failure and left ventricular hypertrophy. He was given a diagnosis of obstructive hypertrophic cardiomyopathy. He eventually underwent septal myectomy, mitral valve replacement, aortic aneurysm repair, and aortic valve replacement with findings of Fabry's disease on surgical pathology. The case discussion focuses on the differential diagnosis for LVH and covers Fabry disease as an HCM mimic. Expert commentary was provided by Dr. Angelika Ewrin. The episode audio was edited by student Dr. Diane Masket. US Cardiology Review is now the official journal of CardioNerds! Submit your manuscript here. CardioNerds Case Reports PageCardioNerds Episode PageCardioNerds AcademyCardionerds Healy Honor Roll CardioNerds Journal ClubSubscribe to The Heartbeat Newsletter!Check out CardioNerds SWAG!Become a CardioNerds Patron! Case Media - An Unusual Cause of Hypertrophic Cardiomyopathy – Cleveland Clinic Pearls - An Unusual Cause of Hypertrophic Cardiomyopathy – Cleveland Clinic Left ventricular hypertrophy is a cardiac manifestation of several different systemic and cardiac processes, and its etiology should be clarified to avoid missed diagnosis and treatment opportunities. Fabry disease is a rare, X-linked inherited disease that can present cardiac and extra-cardiac manifestations, the former of which include hypertrophic cardiomyopathy, conduction defects, coronary artery disease, conduction abnormalities, arrhythmias, and heart failure.  The diagnosis of Fabry disease includes measurement of alpha-galactosidase enzyme activity as well as genetic testing to evaluate for pathogenic variants or variants of unknown significance in the GLA gene. Family members of patients diagnosed with Fabry disease should be screened based on the inheritance pattern.   Multimodality imaging can be helpful in the diagnosis of Fabry disease. Echocardiography can show left ventricular hypertrophy (LVH), reduced global strain, aortic and mitral valve thickening, and aortic root dilation with associated mild to moderate aortic regurgitation. Cardiac MRI can show hypertrophy of papillary muscles, mid-wall late gadolinium enhancement and low-native T1 signal.   The treatment of Fabry disease involves a multi-disciplinary approach with geneticists, nephrologists, cardiologists, nephrologists, and primary care doctors. Enzyme replacement therapy can delay the progression of cardiac disease.    Show Notes - An Unusual Cause of Hypertrophic Cardiomyopathy – Cleveland Clinic What are the causes of left ventricular hypertrophy? LVH is extremely common. It is present in 15-20% of the general population, and is more common in Black individuals, the elderly, obese or hypertensive individuals, with most cases being secondary to hypertension and aortic valve stenosis. In general terms, it is helpful to divide the causes of LVH into three main groups: high afterload states, obstruction to LV ejection, and intrinsic myocardial problems. Increased afterload states include both primary and secondary hypertension and renal artery stenosis. Mechanical obstruction includes aortic stenosis, subaortic stenosis, and coarctation of the aorta. Lastly, several intrinsic problems of the myocardium can cause LV hypertrophy, such as athletic heart with physiological LVH, hypertrophic cardiomyopathy with or without outflow obstruction, and infiltrative or storage diseases such as cardiac amyloidosis, Fabry's disease, or Danon disease, among others.  How does Fabry disease present? Fabry disease is present in all races and is an X-linked lysosomal storage disorder caused by pathogenic variants in the GLA gene that result in reduced alpha-galactosidase enzyme activity,

On Wednesday's Mark Levin Show, why isn't existing immigration law being enforced at the southern border? President Biden himself has admitted in the past that White Europeans will be a minority in the US due to a nonstop stream of immigration. Biden also ignores the antisemitism of the Buffalo, NY shooter and tries to blame the "replacement theory" that his administration perpetuates on Republicans. Rep. Rashida Tlaib's bigoted radicalism and hate for Jews has never been denounced by Democrats or the media. Then, Pelosi's select committee on January 6th is obtaining information that the Department of Justice could not normally obtain, so they are asking Congress to produce transcripts to use for their criminal investigation. This clever work-around violates the liberties of individuals and gives the DOJ an unfair advantage and a reach they wouldn't otherwise have. One's sworn testimony under oath for a legislative proceeding does not meet the same standard the government would have to compel testimony in front of a grand jury for a criminal proceeding. Moreover, subpoenaing President Trump's personal lawyer and former staff for delaying the certification of an election violates the separation of powers, because one has a right to legally challenge an election. Later, the results in the Pennsylvania US Senate primary are headed to a recount between the two highest vote-getters. In other election news Sen. Roy Blount's son draws scrutiny for work by his political canvassing company and lobbying against voter ID, while concealing the source of funding. Afterward, former Ambassador Danny Danon calls in to discuss his new book "In the Lion's Den: Israel and the World." Danon says Israel must remain strong because Israel has the same enemies America has just a lot closer to their homeland. Learn more about your ad choices. Visit megaphone.fm/adchoices