Podcasts about danon

Danny Danon, Israel's Ambassador to the United Nations, says the attacks against Iran will continue. Danon says the goal is to eliminate Iran's nuclear capability and to stop Iran from producing ballistic missiles. He says Iran was preparing to attack Israel again with missiles and Israel could not let that happen. Danon spoke with Bloomberg's Jonathan Ferro and Annmarie Hordern.See omnystudio.com/listener for privacy information.

L'ancien ambassadeur de France en Israël Eric Danon, invité de la matinale est revenu sur l'attaque israélienne visant les sites nucléaires iraniens. Il estime que l'intensité des combats va durer « environ une semaine »Mention légales : Vos données de connexion, dont votre adresse IP, sont traités par Radio Classique, responsable de traitement, sur la base de son intérêt légitime, par l'intermédiaire de son sous-traitant Ausha, à des fins de réalisation de statistiques agréées et de lutte contre la fraude. Ces données sont supprimées en temps réel pour la finalité statistique et sous cinq mois à compter de la collecte à des fins de lutte contre la fraude. Pour plus d'informations sur les traitements réalisés par Radio Classique et exercer vos droits, consultez notre Politique de confidentialité.Hébergé par Ausha. Visitez ausha.co/politique-de-confidentialite pour plus d'informations.

A gene therapy clinical trial for Danon disease run by Rocket Pharmaceuticals has been suspended following the death of a patient. MIT and Recursion have released Boltz-2, an open-source tool that predicts molecular binding affinity at newfound speed and accuracy, aiming to democratize commercial drug discovery. Intellia Therapeutics saw its stock nosedive late last week after a patient in its Phase III trial of the CRISPR-based therapy experienced non-lethal liver toxicity. In other news, a therapeutic plasma exchange regimen combined with intravenous immunoglobulin reduced some biomarkers of biological age in humans. Sanofi has agreed to acquire Blueprint Medicines for up to $9.5 billion, and a universal CAR T cell therapy was produced by applying CRISPR gene editing to cells donated by healthy individuals. Join GEN editors Corinna Singleman, PhD, Alex Philippidis, Fay Lin, PhD, and Uduak Thomas for a discussion of the latest biotech and biopharma news.  Listed below are links to the GEN stories referenced in this episode of Touching Base Danon Disease Patient Dies in Rocket Gene Therapy Trial By Alex Philippidis, GEN, May 27, 2025 Boltz-2 Released to Democratize AI Molecular Modeling for Drug Discovery By Fay Lin, PhD, GENEdge, June 6, 2025 StockWatch: Intellia Stumbles on News of Patient's Severe Liver Toxicity By Alex Philippidis, GEN, May 30, 2025 The State of CRISPR Summit Registration https://bit.ly/CRISPR25 Plasma Exchange in Humans Reduces Biological Age by Over Two Years GEN, June 1, 2025 Sanofi to Acquire Blueprint Medicines for Up to $9.5B By Alex Philippidis, GEN Edge, June 2, 2025 "Universal" CAR-T Immunotherapy Targets Relapsed/Refractory Blood Cancers GEN, May 30, 2025 Hosted on Acast. See acast.com/privacy for more information.

Good morning from Pharma and Biotech daily: the podcast that gives you only what's important to hear in Pharma and Biotech world.Former Chinook board member, Rouzbeh Haghighat, has been indicted for insider trading related to Novartis' $3.2 billion acquisition of the company. Despite this scandal, pharma R&D spending increased in 2024, climbing 1.5% across the global pharmaceutical sector. The acquisition of SiteOne by Lilly follows Vertex into the non-opioid pain space, providing diversification for Lilly, which has been focusing on obesity and diabetes treatments. Meanwhile, AbbVie's Allergan cuts over 200 staff after a botched marketing campaign, and Inflarx axes a rare skin disease study due to disappointing late-stage data.AGC Biologics will be at Bio International in Boston to showcase their global capabilities in drug production. Vaccine overhaul, rocket grounding, and drug price transparency are also highlighted in the latest news. Biogen's strategy for Zurzuvae shifts as obstetricians/gynecologists rise to the front lines. Drug price transparency in the US is discussed as being easier said than done. Additionally, Rocket's gene therapy for Danon disease is on hold after a patient death, and four biotechs are facing uncertainty in the COVID-19 vaccine landscape.Global pharmaceutical companies are increasing their research and development spending despite political and economic challenges. Biogen is shifting its strategy for the drug Zurzuvae as obstetricians and gynecologists become more involved. Drug price transparency in the US is still a challenge, despite efforts to increase transparency. Trilink has introduced a new poly(A) tail modification to enhance protein expression.In other news, a former Chinook board member has been indicted for insider trading, Trump has appointed Dr. Oz to lead drug pricing negotiations, and Lilly is following Vertex into non-opioid pain treatment with a SiteOne acquisition. Sanofi has purchased Vigil for $470 million to reignite an Alzheimer's target.

Good morning from Pharma and Biotech Daily: the podcast that gives you only what's important to hear in Pharma and Biotech world.A patient death has led to the halt of Rocket's gene therapy trial for Danon disease, due to complications from an acute systemic infection. This incident highlights the unpredictable nature of gene therapies and may pose challenges for investment in the field. On the other hand, mRNA technology has been both helped and hindered by the COVID-19 pandemic. While the pandemic has increased interest and funding in mRNA research, vocal skeptics of COVID-19 vaccinations have negatively impacted the reputation of mRNA technology. Despite this, some see promise in mRNA for therapeutics in cancer and rare diseases.In other news, Prothena is considering business options after a failed phase III trial, and a new biotech company has been launched to focus on neuro diseases. Additionally, AGC Biologics will be at Bio International to showcase their capabilities in protein biologics and advanced therapies.mRNA technology played a significant role in combating COVID-19, but is now facing scrutiny due to vaccine skeptics and cuts in government funding for research. Despite this, the pandemic accelerated advancements in mRNA therapeutics for cancer and rare diseases. The lack of FDA-approved treatments for rare diseases, particularly in children, highlights a critical need for innovation in this area. The American Association for Cancer Research's annual conference will unveil data that could impact cancer treatment, while the future of vaccine development faces challenges amidst regulatory changes and funding issues. Additionally, advancements in cell and gene therapy are on the horizon. Suggestions for coverage topics in the biopharma industry are welcomed.

The name of the biopharma game this season is vaccines—and RFK Jr. wasted no time returning from Memorial Day Weekend before making news on this front, removing the COVID-19 vaccine from the list of recommended immunizations for healthy kids and pregnant women on Tuesday. This follows a rash of recent moves, including a new risk-based strategy for the approval of new COVID vaccines focused on adults over 65 and high-risk individuals six months to 64 years of age and a request that Moderna and partners Pfizer and BioNTech update the myocarditis risk on their vaccines' labels.This increased vaccine scrutiny by the FDA and Department of Health and Human Services is having a significant impact on biopharma companies, several of whom have received stop-work orders on next-gen COVID vaccines. Meanwhile, Moderna last week pulled the biological license application for its combination COVID-19/flu vaccine, anticipating a request for additional data on flu shot efficacy from the FDA, as mRNA technology continues to be scrutinized after playing the hero during the pandemic. Also last week, the White House released its Make America Healthy Again (MAHA) report, which took aim at vaccines, along with pharma lobbying and GLP-1s.Also on the policy front, a California judge issued an order Thursday that indefinitely stops HHS' goal of reducing its divisions from 28 to 15 and firing upwards of 10,000 employees, among other reorganization and mass layoff plans. And speaking of government plays that could receive judicial pushback, we received a couple of new updates on the Most Favored Nation (MFN) front: first, President Donald Trump appointed his CMS chief Mehmet Oz as the leader of drug pricing negotiations, calling him “one tough hombre,” and second, HHS provided new guidance for streamlining the process for states to import drugs from Canada.In the obesity realm, Eli Lilly is calling out the Centers for Medicare and Medicaid Services. In an open letter last week, Lilly voiced its displeasure with the agency for a final ruling that left its Zepbound and Novo Nordisk's Wegovy out of Medicare Advantage and Part D coverage in 2026.And in the R&D realm, we returned from the long weekend to sad news from Rocket Pharmaceuticals, as the company reported that its pivotal Danon disease trial is on hold after the death of a young patient. The death—extremely sad on a human level—is also a setback for the gene therapy space, which had been buoyed earlier this month by the success of a personalized CRISPR treatment received by baby KJ.Finally, BioSpace looks ahead to ASCO#25 where Dan Samorodnitsky will be on the ground in Chicago.

Une audience particulièrement houleuse s'est tenue ce mardi 8 avril 2025 devant la Cour suprême israélienne, symbole des tensions politiques dans le pays. Les recours contre le limogeage du chef de l'Agence de la sécurité intérieure (Shin Bet), Ronen Bar, étaient examinés. Cette décision est dénoncée par ses détracteurs comme une dérive autocratique du pouvoir. Tout comme le vote à l'unanimité, fin mars, d'une motion de défiance inédite contre la procureure générale Gali Baharav-Miara. Dans le contexte de l'offensive à Gaza et de la colonisation en Cisjordanie, Israël constitue-t-il encore une démocratie ? Qu'est-ce qui pourrait stopper le Premier ministre Benyamin Netanyahu ?Pour en débattre Sylvaine Bulle, sociologue, chercheuse à l'École des hautes études en sciences sociales), autrice du livre Sociologie de Jérusalem (Éditions de La Découverte, 2020) Rina Bassist, correspondante de la radio israélienne à Paris et rédactrice au journal Al-Monitor Éric Danon, ambassadeur de France en Israël de 2019 à 2023À lire aussiIsraël: Benyamin Netanyahu mis en cause pour «conflit d'intérêts» pour le renvoi du chef du Shin Bet

Une audience particulièrement houleuse s'est tenue ce mardi 8 avril 2025 devant la Cour suprême israélienne, symbole des tensions politiques dans le pays. Les recours contre le limogeage du chef de l'Agence de la sécurité intérieure (Shin Bet), Ronen Bar, étaient examinés. Cette décision est dénoncée par ses détracteurs comme une dérive autocratique du pouvoir. Tout comme le vote à l'unanimité, fin mars, d'une motion de défiance inédite contre la procureure générale Gali Baharav-Miara. Dans le contexte de l'offensive à Gaza et de la colonisation en Cisjordanie, Israël constitue-t-il encore une démocratie ? Qu'est-ce qui pourrait stopper le Premier ministre Benyamin Netanyahu ?Pour en débattre Sylvaine Bulle, sociologue, chercheuse à l'École des hautes études en sciences sociales), autrice du livre Sociologie de Jérusalem (Éditions de La Découverte, 2020) Rina Bassist, correspondante de la radio israélienne à Paris et rédactrice au journal Al-Monitor Éric Danon, ambassadeur de France en Israël de 2019 à 2023À lire aussiIsraël: Benyamin Netanyahu mis en cause pour «conflit d'intérêts» pour le renvoi du chef du Shin Bet

Featuring articles on bacterial vaginosis, diabetes prevention, Danon disease, chronic spontaneous urticaria, and VITT-like monoclonal gammopathy of thrombotic significance; a review article on micronutrients; a Clinical Problem-Solving on unveiling the unforeseen; and Perspectives on bankruptcy and genetic information, on drug development for rare diseases, on facing political attacks on medical education, and on sustaining equity efforts in the face of regression.

Sam Danon, the managing partner at Hunton Andrews Kurth, talks about the importance of firm culture, what associates want out of a law firm and how building his litigation practice helped him establish credibility as a manager. 

NEW YORK (STATI UNITI) (ITALPRESS) - “Tutti gli ostaggi devono tornare a casa e Hamas non deve restare a Gaza. Chiunque voglia una soluzione stabile per il Medio Oriente e per la pace deve sapere che Hamas non può restare in gioco. Siamo molto determinati su questo punto”. Lo ha detto ai microfoni dell'Italpress Danny Danon, ambasciatore di Israele alle Nazioni Unite, al Palazzo di Vetro. Danon è intervenuto al Consiglio di Sicurezza accompagnata dall'ex ostaggio Noa Argamani, che era stata rapita da Hamas nell'attacco del 7 ottobre 2023.xo9/sat/gsl (Video di Stefano Vaccara)

NEW YORK (STATI UNITI) (ITALPRESS) - “Tutti gli ostaggi devono tornare a casa e Hamas non deve restare a Gaza. Chiunque voglia una soluzione stabile per il Medio Oriente e per la pace deve sapere che Hamas non può restare in gioco. Siamo molto determinati su questo punto”. Lo ha detto ai microfoni dell'Italpress Danny Danon, ambasciatore di Israele alle Nazioni Unite, al Palazzo di Vetro. Danon è intervenuto al Consiglio di Sicurezza accompagnata dall'ex ostaggio Noa Argamani, che era stata rapita da Hamas nell'attacco del 7 ottobre 2023.xo9/sat/gsl (Video di Stefano Vaccara)

Tous les samedis et dimanches, dans Europe 1 Matin week-end, Alexandre Devecchio, rédacteur en chef du service débats du Figaro, livre son édito.

Tous les samedis et dimanches, dans Europe 1 Matin week-end, Alexandre Devecchio, rédacteur en chef du service débats du Figaro, livre son édito.

Die Israeliese ambassadeur na die VN, Danny Danon, sê hy kan glad nie verstaan waaroor daar ‘n bohaai is oor die verskuiwing van Palestyne uit Gaza sodat president Donald Trump dit kan omskep in die Riviera van die Midde-Ooste nie. Hy het met SkyNews gepraat en sê as mense wil trek moet hulle kan.

Summary:  This week on The Genetics Podcast, Patrick is joined by Eric Adler, Chief Medical Officer and Head of Research at Lexeo Therapeutics and Professor of Medicine at University of California San Diego. Eric shares his experience with genetic cardiomyopathy and his work on gene therapy for Danon disease, drawing from both clinical and research perspectives. Additionally, he explores the evolution of the field and the broader challenges faced by cardiovascular patients. Show Notes:  0:00 Intro to The Genetics Podcast 01:00 Welcome to Eric and his efforts in cardiomyopathy at the bench and bedside 03:32 How modeling genetic diseases using pluripotent stem cells lead Eric to studying Danon disease  04:50 Pivoting from basic to translational research using adeno-associated viruses (AAV)-based gene therapy 07:58 Uncovering genetic cardiomyopathies that were misdiagnosed as idiopathic cardiomyopathy 09:55 Treatment, screening, and penetrance of Danon disease 12:30 Recent successes and remaining challenges in cardiovascular disease 19:47 Battling distrust in the medical profession 21:55 Preventative therapy using APOE2 for patients at risk of early Alzheimer's   25:15 Motivations behind and advantages of Eric's patient-centered approach to therapeutics 27:24 Balancing regulatory requirements for protocols versus patient needs 29:49 The importance of committed clinical partners for successful trial execution 36:08 Eric's passion for cooking and how he won a cooking competition 39:02 Closing remarks and Lexeo Therapeutics' aims for 2025 Find out more Lexeo Therapeutics (https://www.lexeotx.com/) Please consider rating and reviewing us on your chosen podcast listening platform!  https://drive.google.com/file/d/1Bp2_wVNSzntTs_zuoizU8bX1dvao4jfj/view?usp=share_link

El veto de Israel a las operaciones de la agencia de la ONU para los refugiados palestinos (UNRWA) ha elevado la tensión y preocupación internacional. En octubre, el Parlamento israelí aprobó dos leyes que ordenaban la salida de esa agencia del territorio y de Jerusalén Este. En la práctica, la medida limita casi totalmente su operación en Gaza y Cisjordania, porque la ayuda solo entra con el aval de los israelíes. El martes 28 de enero, el embajador de Israel ante la ONU, Danny Danon, dio 48 horas a la agencia de la ONU para los refugiados palestinos (UNRWA) para evacuar sus centros en Jerusalén, en cumplimiento de una ley israelí que prohíbe al organismo prestar servicios en territorio israelí.Israel ha señalado a la UNRWA de mantener vínculos con el grupo palestino islamista Hamás."UNRWA deberá cesar sus operaciones y evacuar todos los locales en los que opera en Jerusalén, incluidas las propiedades situadas en Ma'alot Dafna (en Jerusalén Este) y Kfar Aqueb", dijo Danon en el marco de una sesión del Consejo de Seguridad, en el que se trató la situación de la agencia.El embajador citó la ley aprobada en octubre pasado que prohíbe a la UNRWA prestar servicios en territorio israelí, incluido el este de Jerusalén, donde viven más de 300.000 palestinos.Leer también¿Qué implicaciones tiene para los palestinos la prohibición de operaciones de la UNRWA en Israel?El inminente cese de operaciones de la UNRWA, este 30 de enero, ha disparado las alarmas en la región y de la comunidad internacional porque esta agencia, que cuenta con unos 30.000 empleados, se encarga de algunos servicios básicos, como los sanitarios  y educativos, a los palestinos desplazados tras la creación del Estado de Israel y a sus descendientes, tanto en Gaza y Cisjordania como en Líbano, Siria y Jordania.Creada por la Asamblea General de las Naciones Unidas en 1949, la agencia de la ONU gestiona centros de salud y escuelas en la Franja de Gaza y Cisjordania. Proporciona refugio, alimentos y atención sanitaria y se considera la "columna vertebral" de la ayuda en Gaza.La situación llevó a convocar dos reuniones de urgencia del Consejo de Seguridad de la ONU para discutir el tema.Israel insiste en que la UNRWA se tiene que ir, mientras que la agencia reitera que esto atenta contra la obligación que tiene el Estado israelí con el Derecho Internacional y que solo la Asamblea General de Naciones Unidas puede decidir sobre su mandato.En tanto, el secretario general de la ONU, António Guterres, en una respuesta a Danon, advirtió el martes  que Israel "no tiene derecho a ejercer poderes soberanos en ninguna parte del Territorio Palestino Ocupado, incluyendo el este de Jerusalén", y que su presencia allí es "ilegal" según el Corte Internacional de Justicia.Y añadió que no hay organización capaz de sustituir a la UNRWA, justo cuando está involucrada en la implementación del alto el fuego entre Israel y Hamás, que incluye la liberación de rehenes israelíes y la entrada de ayuda humanitaria en Gaza.Leer también¿Qué impacto tiene el retiro de la UNRWA en la atención humanitaria para Gaza y Jerusalén?¿Cómo afectará el cierre de UNRWA la entrega de ayuda humanitaria para los palestinos y el cese al fuego en Gaza? ¿Se trata de una decisión soberana de Israel que debe ser respetada? Para analizar el tema, participan en El Debate dos invitados.- Desde Barcelona, Cristina Muñoz, directora de Alianza por la Solidaridad, una ONG española que trabaja en Gaza.- Desde Costa Rica, Jesús Aguirre Gorgona, Máster en Derechos Humanos e Historia Judía y profesor de Política Global e Historia Hebrea en el Instituto Doctor Jaim Weizman.

L'ancien ambassadeur de France en Israël analyse le cessez-le-feu au Proche-Orient Mention légales : Vos données de connexion, dont votre adresse IP, sont traités par Radio Classique, responsable de traitement, sur la base de son intérêt légitime, par l'intermédiaire de son sous-traitant Ausha, à des fins de réalisation de statistiques agréées et de lutte contre la fraude. Ces données sont supprimées en temps réel pour la finalité statistique et sous cinq mois à compter de la collecte à des fins de lutte contre la fraude. Pour plus d'informations sur les traitements réalisés par Radio Classique et exercer vos droits, consultez notre Politique de confidentialité.Hébergé par Ausha. Visitez ausha.co/politique-de-confidentialite pour plus d'informations.

On Friday's Mark Levin Show, President Biden can't leave the office quick enough. He now claims to have amended the Constitution. Biden announced that the Equal Rights Amendment is the “law of the land,” despite the Justice Department and the U.S. archivist saying the President could not ratify the Constitutional amendment. Biden is lawless then he lectures us about the rule of law. According to Democrats, you can do anything if it's in pursuit of the radical left agenda. Also, Ambassador Danny Danon calls in to discuss the Israel/Hamas ceasefire. This is not a peace agreement; Israel keeps the right to go into Gaza and finish off Hamas if necessary. Danon says they are determined to finish the job but will pause to get the hostages back.  Later, Democrats keep telling us we have to fix our immigration laws, but they're not broken.  We have very detailed immigration laws which work if they are enforced. The problem is Democrats lack of virtue and lack of execution - its intentional.  It will be important to have a Governor in the DHS position – Kristi Noem will be fantastic. Afterward, a unanimous Supreme Court upheld the TikTok ban. It can still survive; it just needs new American ownership. We can't allow China to control Americans' data. Learn more about your ad choices. Visit podcastchoices.com/adchoices

For review:1. US CENTCOM Forces Strike Houthi Rebel Targets.On Dec. 30 and 31, US Navy ships and aircraft targeted a Houthi command and control facility and advanced conventional weapon (ACW) production and storage facilities that included missiles and uncrewed aerial vehicles (UAVs). 2. Israeli Ambassador (Danny Danon) to UN Gives Last Warning to Houthis. “To the Houthis, perhaps you have not been paying attention to what has happened to the Middle East over the past year. Well, allow me to remind you what has happened to Hamas, to Hezbollah, to Assad, to all those who have attempted to destroy us. Let this be your final warning,” Danon told the UN Security Council. 3. Latest in Israel - Hamas Hostage Negotiations. Israel & Hamas disagree on number of living Hostages to be released.4. Latest US Security Assistance Package to Ukraine worth $1.25 Billion.In addition, the US Treasury Department meanwhile announced the disbursement of $3.4 billion in direct budgetary support for Ukraine. 5. Greece to provide 24 x Sea Sparrow Missiles to Ukraine. The missiles are part of a broader defense package for Ukraine, including artillery shells, weaponry, and ammunition.6. Russian Foreign Minister (Sergei Lavrov) on President-elect Trump Peace proposal: “Of course, we are not satisfied with the proposals being voiced by representatives of the president-elect to postpone Ukrainian NATO membership for 20 years and to send to Ukraine a peacekeeping contingent of ‘British and European forces,'” Lavrov said. 7. Turkish Drone Maker Baykar purchases Italian aviation firm Piaggio Aerospace. 

CardioNerds (Dr. Dan Ambinder and guest host, Dr. Pooja Prasad) join Dr. Donny Mattia from Phoenix Children's pediatric cardiology fellowship, Dr. Sri Nayak from the Mayo Clinic – Arizona adult cardiology fellowship, and Dr. Harrison VanDolah from the University of Arizona College of Medicine - Phoenix Med/Peds program for a sunrise hike of Piestewa Peak, followed by some coffee at Berdena's in Old Town Scottsdale (before the bachelorette parties arrive), then finally a stroll through the Phoenix Desert Botanical Gardens to discuss a thought-provoking case series full of clinical cardiology pearls. Expert commentary is provided by Dr. Tabitha Moe. Episode audio was edited by Dan Ambinder. They discuss the following case: Cardiology is consulted by the OB team for a 27-year-old female G1, now P1, who has just delivered a healthy baby boy at 34 weeks gestation after going into premature labor. She is experiencing shortness of breath and is found to have a significant past cardiac history, including atrial fibrillation and preexcitation, now with a pacemaker and intracardiac defibrillator. We review the differential diagnosis for peripartum cardiomyopathy (PPCM) and then combine findings from her infant son, who is seen by our pediatric cardiology colleagues and is found to have severe hypertrophic cardiomyopathy (HCM). Genetic testing for both ultimately reveals a LAMP2 mutation consistent with Danon Disease. The case discussion focuses on the differential diagnosis for PPCM, HCM, pearls on Danon Disease and other HCM “phenocopies,” and the importance of good history. US Cardiology Review is now the official journal of CardioNerds! Submit your manuscript here. CardioNerds Case Reports PageCardioNerds Episode PageCardioNerds AcademyCardionerds Healy Honor Roll CardioNerds Journal ClubSubscribe to The Heartbeat Newsletter!Check out CardioNerds SWAG!Become a CardioNerds Patron! Case Media Pearls Peripartum cardiomyopathy is a diagnosis of exclusion – we must exclude other possible etiologies of heart failure! Be on the lookout for features of non-sarcomeric HCM – as Dr. Michelle Kittleson said in Episode 166, “LVH plus” states. HCM with preexcitation, heart block, strong family history, or extracardiac symptoms such as peripheral neuropathy, myopathy, or cognitive impairment should be evaluated for infiltrative/inherited cardiomyopathies! As an X-linked dominant disorder, Danon disease will present differently in males vs females, with males having much more severe and earlier onset disease with extracardiac features. Making the diagnosis for genetic disorders such as Danon disease is important for getting the rest of family members tested as well as the opportunity for specialized treatments such as gene therapy Up to 5% of Danon disease cases may be due to copy number variants, which may be missed in genetic testing that does not do targeted deletion/duplication analysis!). Notes What is the differential diagnosis for peripartum cardiomyopathy? Peripartum cardiomyopathy is a diagnosis of exclusion – we must exclude other possible etiologies of heart failure! First, ensure that you are not missing an acute life-threatening etiology of acute decompensated heart failure – pulmonary embolism, amniotic fluid embolism, ACS, and SCAD should all be ruled out. Second, a careful history can identify underlying heart disease or risk factors for the development of heart failure, such as substance use, high-risk behaviors that put one at risk for HIV infection, and family history that suggests an inheritable cardiomyopathy. Lastly, a careful review of echocardiographic imaging may also identify underlying etiologies that warrant a change in management. Diagnosis of peripartum cardiomyopathy is important to consider as within 7 days of onset, patients may be eligible for treatment with bromocriptine – consider referring ...

Did you miss AHA 2024? Listen here to brief discussions of the latest research. Eric Rubin is the Editor-in-Chief of the Journal. Jane Leopold is a Deputy Editor of the Journal. Stephen Morrissey, the interviewer, is the Executive Managing Editor of the Journal. E.J. Rubin, J. Leopold, and S. Morrissey. NEJM at AHA — Phase 1 Study of AAV9.LAMP2B Gene Therapy in Danon Disease. N Engl J Med. DOI: 10.1056/NEJMe2414477.

Today, we're thrilled to bring you one of the most anticipated episodes of the year with Anthony Danon about the official announcement of Rerail, his brand-new $20M angel fund. You ofc already know Anthony as one of the hosts of our SuperAngel podcast series and part of the powerful duo behind Cocoa together with Carmen

20Angel is a series profiling European angel investors with the best Founder NPS. Episode 19 features Anthony Danon, Founder of Rerail, the latest Solo GP Fund to enter the European ecosytem. Anthony has spent 10 years in fintech as an operator, VC and angel, having done 35+ investments, with a portfolio including, Primer, TrueLayer, Wayflyer and many more. And on Monday 14th October, he announced Rerail I, an angel fund backed and supported by founders and operators. He invests $200k-$500k checks at pre-seed/seed into founders looking to utilize fintech as a strategic advantage, with a skew to Europe, but globally. The format for 20Angel is consistent across show, with questions including: What are some of the non-obvious things they look for when investing in a company? How they work with their Founders? What they think makes a great angel investor? Show links: https://www.rerail.vc/ https://www.linkedin.com/in/anthony-danon-3409099b/

L'acteur, décédé à l'âge de 88 ans, sera inhumé ce samedi 24 août. Géraldine Danon sera présente aux obsèques.

Ecoutez RTL Matin avec Stéphane Boudsocq du 19 août 2024.

Géraldine Danon invitée de Stéphane Boudscoq et les nombreuses réactions à la disparition d'Alain Delon. Sans oublier les hommages rendus sur les chaînes de télévision.

Linda shared her amazing journey from being a Lawyer and hating it to now helping others understand the power of the mind. Linda is an RTT practitioner, life coach and trainer in the power of the mind and thoughts, she helps people get from where they are to where they want to be. She is very passionate about the workings of the subconscious mind and the brain as well as our ability, as human beings, to create the life that we want. And so while Linda creates the life of her dreams, she is helping others do the same.

Partir en expédition sur un voilier avec 4 enfants, dont un bébé de 6 mois, sans avoir jamais navigué… C'est ce qui résume la vie de Géraldine Danon. Dans cet épisode, Géraldine nous raconte ses expéditions à bord de son voilier Fleur Australe avec son mari Philippe Poupon et leurs enfants. Elle se confie sur sa philosophie de vie et sur le fait qu'il faut toujours faire un pas vers le changement avant que le changement n'arrive. Elle nous parle de ce qui lui plaît tant dans cette vie en mer, de cette notion du temps qui, en pleine mer, s'écoule comme dans un sablier. On parle de ses enfants qui ont vécu pendant plus de 13 ans en mer, de Florence Arthaud, son amie de toujours, dont elle vient de relater la vie dans le film "Flo" actuellement au cinéma. Un film qui m'a fait rêver, rire et pleurer, qui m'a surtout prouvé qu'avec passion et détermination, il est possible d'aller très loin. Je suis une grande admiratrice de Géraldine Danon, donc je suis très fière et émue de pouvoir partager ce riche échange avec vous.Pour découvrir les coulisses du podcast :https://www.instagram.com/milkandmamma_/Hébergé par Ausha. Visitez ausha.co/politique-de-confidentialite pour plus d'informations.

Dans cet extrait Géraldine Danon se confie sur sa philosophie de vie et sur le fait qu'il faut toujours faire un pas vers le changement avant que le changement n'arrive.Retrouvez l'épisode complet dimanche soir.Hébergé par Ausha. Visitez ausha.co/politique-de-confidentialite pour plus d'informations.

Ruth Danon grew up on the grounds of a mental hospital where her mother was a psychiatrist and many neighbors were European immigrants fleeing the devastation of World War 2. She forged a winding literary path, publishing four poetry collections and developing a style of teaching that treats writing as a studio art. She moved to Beacon in 2020 and now teaches privately and curates literary events such as the Spring Street Reading Series at Atlas Studios in Newburh and the Beacon Lit Fest,  In this interview Ruth talks about her life and reads a cluster of poems from her new collection, “Turn up the Heat.”  Photo credit: Meredith Heuer 

Today, we're happy to be joined by Edwina Johnson, Head of Global at Alloy, leading company strategy to expand their product into key markets worldwide and launch a GTM team in the UK/EMEA.Previously Head of Global at Alloy, leading company strategy to expand our product into key markets worldwide and launch a GTM team in the UK/EMEA. Before that, COO at Alloy in NYC, taking the team from Seed to Series C and $1.55B valuation. Edwina is also an active angel investor, primarily through Ada Ventures, under the Economic Empowerment thesis, a mentor through Innovate UK's Women in Innovation program, and an Expert in Residence for Sie Ventures. We invite you to listen to this discussion below for some wonderful stories; besides the actionable advice, you can have a sneak peek at the below.Go to eu.vc for our core learnings and the full video interview

Hi Friends,This episode Jess and I discuss resolutions with friends of the podcast Leslie and Danon.  They share their unique perspectives on New Year Resolutions. We all discuss if we agree with them, how effective are they and how we hold ourselves accountable.   There were a few gems I personally got from this conversation.  I hope you do as well. Enjoy.. Happy New Year!email: Bambooearringspod@gmail.comIG @ PodcastbambooearringsPhone 313 744 2087 (Leave a message)

As the events industry continues to evolve as fast as ever, the experience you deliver has never been more important... but we keep seeing the same people repeat the same mistakes of the past.That's why we decided to bring back one of our most popular episodes from last year, and share this conversation with Dan Gingiss - a keynote speaker and author of “The Experience Maker: How to Create Remarkable Experiences That Your Customers Can't Wait to Share.”After spending over two decades leading companies in both Customer Experience and Marketing, Dan let us in on their secret to success!He touched upon topics such as:- How event marketers should be reverse engineering the experiences they create- The WISER framework (and how it applies in events)- How to focus on experience and know what strategies to implement- And much much more!Don't miss out - listen in now for an insightful look at what it takes to make a successful experience that sticks and clicks.Connect with Dan: On his LinkedIn: https://www.linkedin.com/in/dangingiss/ Connect with Me:On my LinkedIn: https://www.linkedin.com/in/matt-kleinrock-9613b22b/   On my Company: https://rockwayexhibits.com/ 

CardioNerds cofounder Dr. Amit Goyal and cardiology fellows from the Cleveland Clinic (Drs. Alejandro Duran Crane, Gary Parizher, and Simrat Kaur) discuss the following case: A 61-year-old man presented with symptoms of heart failure and left ventricular hypertrophy. He was given a diagnosis of obstructive hypertrophic cardiomyopathy. He eventually underwent septal myectomy, mitral valve replacement, aortic aneurysm repair, and aortic valve replacement with findings of Fabry's disease on surgical pathology. The case discussion focuses on the differential diagnosis for LVH and covers Fabry disease as an HCM mimic. Expert commentary was provided by Dr. Angelika Ewrin. The episode audio was edited by student Dr. Diane Masket. US Cardiology Review is now the official journal of CardioNerds! Submit your manuscript here. CardioNerds Case Reports PageCardioNerds Episode PageCardioNerds AcademyCardionerds Healy Honor Roll CardioNerds Journal ClubSubscribe to The Heartbeat Newsletter!Check out CardioNerds SWAG!Become a CardioNerds Patron! Case Media - An Unusual Cause of Hypertrophic Cardiomyopathy – Cleveland Clinic Pearls - An Unusual Cause of Hypertrophic Cardiomyopathy – Cleveland Clinic Left ventricular hypertrophy is a cardiac manifestation of several different systemic and cardiac processes, and its etiology should be clarified to avoid missed diagnosis and treatment opportunities. Fabry disease is a rare, X-linked inherited disease that can present cardiac and extra-cardiac manifestations, the former of which include hypertrophic cardiomyopathy, conduction defects, coronary artery disease, conduction abnormalities, arrhythmias, and heart failure.  The diagnosis of Fabry disease includes measurement of alpha-galactosidase enzyme activity as well as genetic testing to evaluate for pathogenic variants or variants of unknown significance in the GLA gene. Family members of patients diagnosed with Fabry disease should be screened based on the inheritance pattern.   Multimodality imaging can be helpful in the diagnosis of Fabry disease. Echocardiography can show left ventricular hypertrophy (LVH), reduced global strain, aortic and mitral valve thickening, and aortic root dilation with associated mild to moderate aortic regurgitation. Cardiac MRI can show hypertrophy of papillary muscles, mid-wall late gadolinium enhancement and low-native T1 signal.   The treatment of Fabry disease involves a multi-disciplinary approach with geneticists, nephrologists, cardiologists, nephrologists, and primary care doctors. Enzyme replacement therapy can delay the progression of cardiac disease.    Show Notes - An Unusual Cause of Hypertrophic Cardiomyopathy – Cleveland Clinic What are the causes of left ventricular hypertrophy? LVH is extremely common. It is present in 15-20% of the general population, and is more common in Black individuals, the elderly, obese or hypertensive individuals, with most cases being secondary to hypertension and aortic valve stenosis. In general terms, it is helpful to divide the causes of LVH into three main groups: high afterload states, obstruction to LV ejection, and intrinsic myocardial problems. Increased afterload states include both primary and secondary hypertension and renal artery stenosis. Mechanical obstruction includes aortic stenosis, subaortic stenosis, and coarctation of the aorta. Lastly, several intrinsic problems of the myocardium can cause LV hypertrophy, such as athletic heart with physiological LVH, hypertrophic cardiomyopathy with or without outflow obstruction, and infiltrative or storage diseases such as cardiac amyloidosis, Fabry's disease, or Danon disease, among others.  How does Fabry disease present? Fabry disease is present in all races and is an X-linked lysosomal storage disorder caused by pathogenic variants in the GLA gene that result in reduced alpha-galactosidase enzyme activity,

durée : 00:12:43 - L'invité d'un jour dans le monde - par : Fabienne Sintes - Le 7 octobre, l'Etat d'Israël entrait en guerre contre le Hamas à la suite d'attaques sur son sol. Deux mois après le début du conflit, nous faisons un état des lieux de la situation avec Éric Danon, ancien ambassadeur de France en Israël. - invités : Eric Danon - Eric Danon :

durée : 00:37:30 - Le 18/20 · Un jour dans le monde - par : Fabienne Sintes - Le 7 octobre, l'Etat d'Israël entrait en guerre contre le Hamas à la suite d'attaques sur son sol. Deux mois après le début du conflit, nous faisons un état des lieux de la situation avec Éric Danon, ancien ambassadeur de France en Israël. - invités : Eric Danon - Eric Danon : - réalisé par : Tristan Gratalon

durée : 00:37:30 - Le 18/20 · Un jour dans le monde - par : Fabienne Sintes - Le 7 octobre, l'Etat d'Israël entrait en guerre contre le Hamas à la suite d'attaques sur son sol. Deux mois après le début du conflit, nous faisons un état des lieux de la situation avec Éric Danon, ancien ambassadeur de France en Israël. - invités : Eric Danon - Eric Danon : - réalisé par : Tristan Gratalon

Today we are happy to welcome Ambre Soubiran. A mathematician by training, she has spent the first decade of her career working in the equity derivatives and capital markets industry. Amber has a passion for world-changing technologies and is personally interested and invested in the digital assets space since 2012. Amber is currently the CEO of Kaiko, the reference market data provider in the blockchain industry. Kaiko is a global organisation with offices in NYC, London, Paris, and Singapore, servicing top-tier financial institutions and enterprises with reliable and actionable financial data.

Commentary by Dr. Valentin Fuster

Today, we're happy to feature Francesco Simoneschi, Co-Founder and CEO at TrueLayer and angel with 60+ investments.In this episode, Francesco dives deep into his experience going from VC to angel investing, the nuances of angel investing, shedding light on some counterintuitive lessons he's learned along the way. He delves into the importance of trusting your instincts when assessing early-stage startups and why sometimes, early traction can be a red flag.Francesco also shares his strategies for making international investments and the value of building a network of trusted insiders in unfamiliar territories. Plus, he reflects on the soft skills and leadership qualities that he wishes he had focused on earlier in his career.Jump to the parts that matter most to you and watch our core highlights below

Today, we're happy to welcome you to Charlie Delingpole, founder of ComplyAdvantage, an AI-driven financial crime risk and detection technology powered by Complydata. They have raised $100m from Index Ventures, Balderton Capital, OTPP and Goldman Sachs with global hubs in London, New York, and Singapore. In this episode you'll learn:The importance of being part of a strong angel community with peers you trust and whose opinion you valueHow Charlie thinks about activating his network as part of his diligence processWhy Charlie is going from a more international strategy to a more nationally focused oneWhy Charlie believes it's important to impose systematic professional processes on himself when angel investing

Today, we're happy to welcome you to David de Picciotto, Co-founder & CEO of Pledge, a climate software company helping decarbonise the logistics supply chain through its accredited and integrated platform. Founded in 2021 in the UK, Pledge is backed by venture investors including Zinal Growth, Lowercarbon Capital and Visionaries Club. Before Pledge, David worked for Partners Group, a global private equity firm, where he focused on growth equity investments and previously led International Expansion at Revolut, the UK FinTech. David is also the co-founder of media start-up iRewind, where he exited in 2016. David is also one of the trailblazing Sequoia scouts leading the charge in Europe

Today, we're happy to welcome David Nothacker, angel investor, CEO & co-founder of Sennder, a digital truck freight forwarding business. Together with his co-founders, David has built up a team of over 1,000 employees across eleven offices in Europe. In the process, they have been supported by strong investors such as Scania, Accel and Project A, and have secured over €300 million in funding. They are quite active angels, particularly in the German ecosystem.In this episode you will learn:Why David considers his investments into Gorillas and Cargo 1 his most memorable angel dealsDavid's learnings from managing startup boardsWhy David has two different, yet synergistic, investment strategies: investing early in logistics & supply chain startups and co-investing with VCs in opportunistic dealsHow LP investing can complement your angel activities when starting to do more international investmentsHow angel investing makes you a better, more experienced business leader

CardioNerds (Drs. Amit Goyal and Dan Ambinder) join Dr. Mina Fares, Dr. Johannes Bergehr, and Dr. Christina Peter from Cambridge University Hospitals in the UK. They discuss a case involving a man man in his 40's presented with progressive heart failure symptoms. He has extensive background cardiac history including prior episodes of myocarditis and complete heart block status post permanent pacemaker implantation. Ultimately a diagnosis of Danon disease is made. Dr. Sharon Wilson provides the E-CPR for this episode. Audio editing by CardioNerds Academy Intern, Hirsh Elhence. CardioNerds is collaborating with Radcliffe Cardiology and US Cardiology Review journal (USC) for a ‘call for cases', with the intention to co-publish high impact cardiovascular case reports, subject to double-blind peer review. Case Reports that are accepted in USC journal and published as the version of record (VOR), will also be indexed in Scopus and the Directory of Open Access Journals (DOAJ). CardioNerds Case Reports PageCardioNerds Episode PageCardioNerds AcademyCardionerds Healy Honor Roll CardioNerds Journal ClubSubscribe to The Heartbeat Newsletter!Check out CardioNerds SWAG!Become a CardioNerds Patron! Case Summary - A Presentation of Heart Failure and Heart Block with Elusive Genetic Origins - Cambridge University A man in his 40s with a history of cardiac issues, including prior myocarditis and complete heart block, presented with progressive heart failure symptoms. Extensive cardiac investigations were conducted, revealing dilated left ventricle, mild to moderate left ventricular systolic dysfunction, normal coronaries, infero-lateral late gadolinium enhancement on cardiac MRI, and low-level uptake on PET-CT. Differential diagnosis included worsening underlying cardiomyopathy, recurrent myocarditis, tachycardia-related cardiomyopathy, pacemaker-induced LV dysfunction, and sarcoidosis. The patient's condition improved with heart failure medications, and cardiac MRI showed a mildly dilated left ventricle with moderate systolic dysfunction and active inflammation in the anterior wall. Further evaluation indicated a family history of hereditary cardiomyopathy, and the patient exhibited phenotypic features such as early-onset heart disease, arrhythmias, family history of cardiomyopathy, learning problems, intellectual disability, and mild proximal myopathy. Genetic testing confirmed a LAMP2 mutation, leading to the diagnosis of Danon disease. Case Media - A Presentation of Heart Failure and Heart Block with Elusive Genetic Origins - Cambridge University Show Notes -A Presentation of Heart Failure and Heart Block with Elusive Genetic Origins - Cambridge University References - Danon, M. J., Oh, S. J., DiMauro, S., Miranda, A., De Vivo, D. C., & Rowland, L. P. (1981). Lysosomal glycogen storage disease with normal acid maltase. Neurology, 31(1), 51-7. Nishino, I., Fu, J., Tanji, K., Nonaka, I., & Ozawa, T. (2000). Mutations in the gene encoding LAMP2 cause Danon disease. Nature, 406(6798), 906-10. Tanaka, K., Nishino, I., Nonaka, I., Fu, J., & Ozawa, T. (2000). Danon disease is caused by mutations in the gene encoding LAMP2, a lysosomal membrane protein. Nature, 406(6798), 902-6. Maron, B. J., Haas, T. S., Ackerman, M. J., Ahluwalia, A., Spirito, P., Nishino, I., ... & Seidman, C. E. (2009). Hypertrophic cardiomyopathy and sudden death in a family with Danon disease. JAMA, 301(12), 1253-9. Hashem, S., Zhang, J., Zhang, Y., Wang, H., Zhang, H., Liu, L., ... & Wang, J. (2015). AAV-mediated gene transfer of LAMP2 improves cardiac function in Danon disease mice. Stem cells, 33(11), 2343-2350. Chi, L., Wang, H., Zhang, J., Zhang, Y., Liu, L., Wang, J., ... & Hashem, S. (2019). CRISPR/Cas9-mediated gene editing of LAMP2 in patient-derived iPSCs ameliorates Danon disease phenotypes.

The RSB Show 4-14-23 - Shai Danon, Life In Israel, Ula Tinsley, Fasting Tips, Lori Harvey

The past week has been a trying for Israelis, who reeled from a Palestinian gunman's attack outside an East Jerusalem synagogue. Seven people were killed as they finished their Friday Night Shabbat - or Sabbath - worship.  Earlier this week, FOX News Rundown: Evening Edition host Eben Brown spoke with Knesset Member and former Israeli Ambassador to the UN Danny Danon about the attack and how Israel may respond.  Danon is also a leader of the Israel Likud party, the conservative party of Benjamin Netanyahu, who only recently again became Prime Minister and whose new government feels the Palestinian attacks in recent weeks are a test of their leadership.  We have plenty of fresh interviews each day during the week, and sometimes we have more to share. On today's FOX News Rundown, you will hear our interview with former Israeli Ambassador to the UN Danny Danon and get his take on the recent violence in Israel.  Learn more about your ad choices. Visit megaphone.fm/adchoices

On Wednesday's Mark Levin Show, why isn't existing immigration law being enforced at the southern border? President Biden himself has admitted in the past that White Europeans will be a minority in the US due to a nonstop stream of immigration. Biden also ignores the antisemitism of the Buffalo, NY shooter and tries to blame the "replacement theory" that his administration perpetuates on Republicans. Rep. Rashida Tlaib's bigoted radicalism and hate for Jews has never been denounced by Democrats or the media. Then, Pelosi's select committee on January 6th is obtaining information that the Department of Justice could not normally obtain, so they are asking Congress to produce transcripts to use for their criminal investigation. This clever work-around violates the liberties of individuals and gives the DOJ an unfair advantage and a reach they wouldn't otherwise have. One's sworn testimony under oath for a legislative proceeding does not meet the same standard the government would have to compel testimony in front of a grand jury for a criminal proceeding. Moreover, subpoenaing President Trump's personal lawyer and former staff for delaying the certification of an election violates the separation of powers, because one has a right to legally challenge an election. Later, the results in the Pennsylvania US Senate primary are headed to a recount between the two highest vote-getters. In other election news Sen. Roy Blount's son draws scrutiny for work by his political canvassing company and lobbying against voter ID, while concealing the source of funding. Afterward, former Ambassador Danny Danon calls in to discuss his new book "In the Lion's Den: Israel and the World." Danon says Israel must remain strong because Israel has the same enemies America has just a lot closer to their homeland. Learn more about your ad choices. Visit megaphone.fm/adchoices