Podcasts about Bortolotti

durée : 00:53:28 - Vous avez pris votre retraite avant l'heure (retraite anticipée pour carrière longue, handicap, convenance personnelle) racontez-nous ? Avec Audrey Bortolotti de la CARSAT Nord Est

Nicoletta Bortolotti"I bambini di Gaza"Mondadori Editorewww.mondadori.itEstate 2003. Mahmud e Samir vivono a Gaza City, una città colpita ogni giorno dai bombardamenti. Non potrebbero essere più diversi, ma hanno una grande passione in comune: il surf. Appena possono, corrono al mare ad aspettare un'onda da cavalcare, quell'attimo sospeso in cui sentirsi liberi, l'unico modo per scappare, anche solo per un momento, dalle difficoltà della guerra. I due ragazzi si incontrano spesso sulla spiaggia, ma si guardano a distanza con curiosità mista a sospetto: uno è palestinese, l'altro israeliano, e le loro famiglie non vogliono neanche che si rivolgano la parola. Ma l'incontro con Bill, un maestro di surf, cambierà ogni cosa. Perché nel surf, come nell'amicizia, non esistono barriere...Un racconto di libertà e coraggio, ispirato a fatti realmente accaduti, già conosciuto come Sulle onde della libertà.Una storia di amicizia a Gaza City, torna in libreria in una nuova veste cinematografica.Titolo originale: RollRegia: Loris LaiCast: Lyna Khoudri, Marwin Hemdan, Mikael Fridel, Ruth Rosenfeld, Tom Rhys HarriesDurata: 01:52Anno: 2024Nicoletta BortolottiÈ un'affermata autrice italo-svizzera. Vive a Milano dove lavora in ambito editoriale. Ha pubblicato libri per adulti e ragazzi con le più importanti case editrici italiane; per Mondadori ha scritto Quelle in cielo non erano stelle (2021), finalista al premio Bancarellino, e ha collaborato a Un sogno al microscopio (con Piera Levi-Montalcini e Alberto Cappio, 2022), dedicato alla storia di Rita Levi-Montalcini. Nel 2023 è stata candidata al Premio Strega con Un giorno e una donna (HarperCollins, 2022).IL POSTO DELLE PAROLEascoltare fa pensarewww.ilpostodelleparole.itDiventa un supporter di questo podcast: https://www.spreaker.com/podcast/il-posto-delle-parole--1487855/support.

D'un projet étudiant, son site atteint les 90.000 visiteurs mensuels, WP Marmite est devenu la référence WordPress francophoneDans l'épisode du jour, Alex revient sur la success story du site de référence qu'on ne présente plus,Et surtout, Alex va vous dire exactement- Quels plugins choisir- Quelles structures de pages WordPress mettre en place- Quels sont les prérequis à prendre en compte lorsqu'on choisit un thème WPLe tout en mode 20% d'outils pour 80% de résultats.Alex te donne avec humilité le parfait playbook du site WordPress optimisé pour le SEO en 2024 dans cet épisode.Un épisode full valeur avec une personne de valeur. Un like + commentaire pour soutenir ce podcast et le faire connaître au maximum ❤️Hébergé par Ausha. Visitez ausha.co/politique-de-confidentialite pour plus d'informations.

Autori svizzeri per nascita o adozione, oggi ad Alice, e libri che coprono un ampio spettro di generi letterari. C'è il romanzo storico di Nicoletta Bortolotti, che è di Sorengo ma da molti anni vive in Italia; c'è la fiction drammatica di Olimpia De Girolamo, che è nata a Napoli e vive in Ticino. E poi, da Ginevra, c'è il thriller di Joël Dicker, 13 milioni di copie vendute in tutto il mondo (beninteso, prima della pubblicazione dell'ultimo romanzo Un animale selvaggio). Quella di Joël Dicker sarà la prima voce che ascolteremo in questa puntata con Alice, per raccontare Un animale selvaggio di cui è uscita da qualche settimana la traduzione in italiano per La nave di Teseo. Parleremo poi con Nicoletta Bortolotti, professionista dell'editoria e scrittrice, che proprio quest'anno ha visto il suo I bambini di Gaza – Le onde della libertà diventare un film. Il suo ultimo libro Un giorno e una donna è un romanzo storico che gira intorno alla prima scrittrice protofemminista della storia: Christine de Pizan.Infine sarà con noi Olimpia De Girolamo, che torna nelle librerie con Volontà pubblicato da Gabriele Capelli editore. Come in Tutto ciò che siamo stati, suo romanzo d'esordio, una scomparsa diventa il tragico motore della vicenda, costruita con un alternarsi di terza e prima persona.

In episode 3 of season 5, we discuss the attribute of realistic optimism and how it helps us be better decision-makers. SUMMARYRealistic optimism accepts the reality - both good and bad - of every situation, but applies a positive attitude to make the best of the situation and pursue our goals with energyPessimism isn't the same as realism. Pessimism focuses on unlikely negative outcomes and ignores the statistical likelihood that something bad will happen. Being sceptical means not accepting things on face value - it is a questioning, curious mindset that serves us better than pessimismWe can build realistic optimism by applying the ABC framework to analyse how we respond to adversity, adjusting our beliefs to support a more constructive decision that produces better consequences that help us achieve our goalsRESOURCESCurious to learn more about realistic optimism? Here's the details of some interesting articles:https://www.forbes.com/sites/forbescoachescouncil/2021/01/07/how-to-incorporate-realistic-optimism-into-your-life/?sh=24d6696876f0 Carver, Charles S., Michael F. Scheier, and Suzanne C. Segerstrom. “Optimism.” Clinical Psychology Review 30, no. 7 (2010): 879–89. https://doi.org/10.1016/j.cpr.2010.01.006.Jefferson, Bortolotti & Kuzmanovic, ‘What is Unrealistic Optimism?', Consciousness & Cognition, 50 (2017)Martin Seligman, ‘Learned Optimism: How to Change Your Mind and Your Life' (Vintage Books; New York, 1990)Are you, or someone you know, negatively impacted by gambling? Here's a couple of links that might help:https://www.gamblinghelponline.org.au/https://www.helpguide.org/articles/addictions/gambling-addiction-and-problem-gambling.htm IN OUR NEXT EPISODE...In episode 4 of this season, we'll be discussing the benefits of being 'knowledge-hungry'. Don't miss it!

Today's episode features Antonio Bortolotti, who runs the vacation Rental World Summit with his wife, Christina. It's become the preeminent event in Europe and the Middle East for vacation rental professionals. In this episode, Antonio and I recount this most extraordinary moment on stage at the end of the Vacation Rental World Summit in Barcelona just a couple weeks ago. We go through some of the sequences that neither of us could have fathomed, along with the consequences of what happened on stage and these shifts in priorities that myself and Antonio and I'm guessing a lot of you are going through in life as we evolve. This episode is brought to you by Breezeway, https://www.breezeway.io/vrmb the best-in-class property care and operations platform, and bnbfinder, https://www.bnbfinder.com/list, a book direct marketplace with a 20-year history connecting travelers with unique places to stay. No commissions, no processing fees, no service fees. Plain and simple.

Una giovane madre della provincia di Bergamo è stata arrestata.Seguimi su YouTube: https://www.youtube.com/channel/UClkB_8jqDS7SWoltMjIu-3Q/Supporta il progetto qui: https://www.paypal.com/paypalme/pierjcSupport this podcast at — https://redcircle.com/storia/donationsAdvertising Inquiries: https://redcircle.com/brandsPrivacy & Opt-Out: https://redcircle.com/privacy

In dieser  Ausgabe schauen wir auf das perfekte Finalwochenende der DTM-Saison 2023, bei dem der Champion Thomas Preining im Manthey-EMA-Porsche triumphierte. Nachdem Preining mit seinen drei Punkten im Sonntags-Qualifying den Titel gesichert hatte, bewies er seine Dominanz in Hockenheim, indem er sowohl die Pole-Positionen als auch beide Siege sicherte. Doch sein hartnäckiger Titelrivalen Mirko Bortolotti im SSR-Lamborghini gab nicht auf und machte ihm das Leben schwer. In einem packenden Rennen behielt Preining die Oberhand, während Bortolotti hartnäckig den zweiten Platz gegen starke Konkurrenz verteidigte. Das Rennen versprach von Anfang bis Ende Hochspannung und wurde in der dritten Runde durch eine Safety-Car-Phase unterbrochen, nachdem ...Du möchtest deinen Podcast auch kostenlos hosten und damit Geld verdienen? Dann schaue auf www.kostenlos-hosten.de und informiere dich. Dort erhältst du alle Informationen zu unseren kostenlosen Podcast-Hosting-Angeboten. kostenlos-hosten.de ist ein Produkt der Podcastbude.Gern unterstützen wir dich bei deiner Podcast-Produktion.

In dieser  Ausgabe schauen wir auf das perfekte Finalwochenende der DTM-Saison 2023, bei dem der Champion Thomas Preining im Manthey-EMA-Porsche triumphierte. Nachdem Preining mit seinen drei Punkten im Sonntags-Qualifying den Titel gesichert hatte, bewies er seine Dominanz in Hockenheim, indem er sowohl die Pole-Positionen als auch beide Siege sicherte. Doch sein hartnäckiger Titelrivalen Mirko Bortolotti im SSR-Lamborghini gab nicht auf und machte ihm das Leben schwer. In einem packenden Rennen behielt Preining die Oberhand, während Bortolotti hartnäckig den zweiten Platz gegen starke Konkurrenz verteidigte. Das Rennen versprach von Anfang bis Ende Hochspannung und wurde in der dritten Runde durch eine Safety-Car-Phase unterbrochen, nachdem ...Du möchtest deinen Podcast auch kostenlos hosten und damit Geld verdienen? Dann schaue auf www.kostenlos-hosten.de und informiere dich. Dort erhältst du alle Informationen zu unseren kostenlosen Podcast-Hosting-Angeboten. kostenlos-hosten.de ist ein Produkt der Podcastbude.Gern unterstützen wir dich bei deiner Podcast-Produktion.

It's The Week In Sports Cars show featuring Marshall Pruett and Pfaff Motorsports' boss Steve Bortolotti who explores the team's switch from Porsche to McLaren in IMSA'a GTD Pro class starting in 2024. If you'd like to join the PrueDay podcast listener group, send an email to pruedayrocks@gmail.com and you'll be invited to participate in the Discord chat that takes place every day and meet up with your new family at events. Every episode of The Week In Sports Cars is brought to us by Cooper Tires, the Justice Brothers, and TorontoMotorsports.com. Play on Podbean.com: https://marshallpruett.podbean.com/ Subscribe: https://marshallpruettpodcast.com/subscribe Join our Facebook Group: https://www.facebook.com/MarshallPruettPodcast [WSC]

Kelvin van der Linde gewinnt das Samstagsrennen der DTM am Red-Bull-Ring in Spielberg, sein erster Sieg seit 2021. Das Rennen erstreckte sich über 37 Runden bei wechselnden Bedingungen. Teamkollege Ricardo Feller beeindruckt mit einer Aufholjagd von Platz 26 auf den dritten Platz. Maro Engel belegt den fünften Platz, während Mirko Bortolotti seine Gesamtführung trotz eines neunten Platzes behält. Am Sonntag gewinnen Rene Rast und Sheldon van der Linde (Schubert) das Rennen, wobei Thomas Preining (Manthey-EMA-Porsche) die Tabellenführung übernimmt. Mirko Bortolotti erlebt ein Rennen zum Vergessen mit einem Reifenschaden und einem weiteren Problem im Cockpit. Rast feiert seinen ersten Sieg als BMW-Pilot, während ...Du möchtest deinen Podcast auch kostenlos hosten und damit Geld verdienen? Dann schaue auf www.kostenlos-hosten.de und informiere dich. Dort erhältst du alle Informationen zu unseren kostenlosen Podcast-Hosting-Angeboten. kostenlos-hosten.de ist ein Produkt der Podcastbude.Gern unterstützen wir dich bei deiner Podcast-Produktion.

Kelvin van der Linde gewinnt das Samstagsrennen der DTM am Red-Bull-Ring in Spielberg, sein erster Sieg seit 2021. Das Rennen erstreckte sich über 37 Runden bei wechselnden Bedingungen. Teamkollege Ricardo Feller beeindruckt mit einer Aufholjagd von Platz 26 auf den dritten Platz. Maro Engel belegt den fünften Platz, während Mirko Bortolotti seine Gesamtführung trotz eines neunten Platzes behält. Am Sonntag gewinnen Rene Rast und Sheldon van der Linde (Schubert) das Rennen, wobei Thomas Preining (Manthey-EMA-Porsche) die Tabellenführung übernimmt. Mirko Bortolotti erlebt ein Rennen zum Vergessen mit einem Reifenschaden und einem weiteren Problem im Cockpit. Rast feiert seinen ersten Sieg als BMW-Pilot, während ...Du möchtest deinen Podcast auch kostenlos hosten und damit Geld verdienen? Dann schaue auf www.kostenlos-hosten.de und informiere dich. Dort erhältst du alle Informationen zu unseren kostenlosen Podcast-Hosting-Angeboten. kostenlos-hosten.de ist ein Produkt der Podcastbude.Gern unterstützen wir dich bei deiner Podcast-Produktion.

Mirko Bortolotti beschrieb seinen Kampf um den Sieg gegen Ricardo Feller im DTM-Rennen am Sonntag auf dem Lausitzring als "wirklich hart und fair". Er sagte, dass der "kleinste Fehler" es dem Audi-Fahrer ermöglicht hätte, den Sieg zu erlangen. Bortolotti holte am Sonntag in dem 60-minütigen Rennen auf der deutschen Strecke seinen zweiten Sieg des Jahres und wurde damit der erste wiederholte Sieger der Saison. Gleichzeitig übernahm er die Führung in der Meisterschaft von Manthey EMA-Fahrer Thomas Preining. Der Sieg folgte einem hart umkämpften Rennen, in dem Fellers ABT Sportsline Audi R8 LMS GT3 Evo II den SSR Performance Lamborghini Huracan GT3 EVO2 konstant ...Du möchtest deinen Podcast auch kostenlos hosten und damit Geld verdienen? Dann schaue auf www.kostenlos-hosten.de und informiere dich. Dort erhältst du alle Informationen zu unseren kostenlosen Podcast-Hosting-Angeboten. kostenlos-hosten.de ist ein Produkt der Podcastbude.Gern unterstützen wir dich bei deiner Podcast-Produktion.

Mirko Bortolotti beschrieb seinen Kampf um den Sieg gegen Ricardo Feller im DTM-Rennen am Sonntag auf dem Lausitzring als "wirklich hart und fair". Er sagte, dass der "kleinste Fehler" es dem Audi-Fahrer ermöglicht hätte, den Sieg zu erlangen. Bortolotti holte am Sonntag in dem 60-minütigen Rennen auf der deutschen Strecke seinen zweiten Sieg des Jahres und wurde damit der erste wiederholte Sieger der Saison. Gleichzeitig übernahm er die Führung in der Meisterschaft von Manthey EMA-Fahrer Thomas Preining. Der Sieg folgte einem hart umkämpften Rennen, in dem Fellers ABT Sportsline Audi R8 LMS GT3 Evo II den SSR Performance Lamborghini Huracan GT3 EVO2 konstant ...Du möchtest deinen Podcast auch kostenlos hosten und damit Geld verdienen? Dann schaue auf www.kostenlos-hosten.de und informiere dich. Dort erhältst du alle Informationen zu unseren kostenlosen Podcast-Hosting-Angeboten. kostenlos-hosten.de ist ein Produkt der Podcastbude.Gern unterstützen wir dich bei deiner Podcast-Produktion.

Una delle prerogative per parlare di videogiochi in modi diversi da quelli mainstream è l'appropriazione di nuovi spazi di aggregazione e l'unico modo per farlo è insieme, con ogni contributo possibile. In quanto "radici di edera che crescono nelle crepe del capitalismo" (cit.), abbiamo deciso di dare spazio a Zona Warpa, la festa del videogioco ribelle e itinerante. Un progetto orizzontale nato da diversi cervelli, tra cui quello di Fabio "Kenobit" Bortolotti che è venuto nel nostro spazio per parlare dell'iniziativa e offrire numerosi spunti di riflessione sul modo in cui si parla di videogiochi e sul trasformare le difficoltà di tuttə in nuove opportunità. Con Luca Parri, Francesco Paternesi e Lorena Rao. Ospite: Fabio "Kenobit" Bortolotti

Steve Bortolotti is the General Manager at Pfaff Motorsports, one of the most successful sports car racing programs in North America. The team's long history includes Championships in the Porsche GT3 Cup Challenge, the Pirelli World Challenge, and the IMSA WeatherTech SportsCar Championship. This year's drivers include Klause Bachler, Laurens Vanthroor, and Patrick Pilet. Long time listeners will remember Laurance Yap, Pfaff's Marketing Director, is a past guest on Cars Yeah.  

Learn about the life, work, struggles, and achievements of Maria Bortolotti Casoni. For show notes and more information check out our website https://www.shebuildspodcast.com/episodes/mariabortolotticasoni

2/02/2023 - Le RPOD - Au sommaire de cet édito du 2 Fevrier : WEC : Kvyat et Bortolotti rejoignent Prema en LMP2 !

Une femme pleine d'entrain et de motivation, une femme salariée qui décide de jouer à la wonderwoman pour changer de vie professionnelle mais aussi de vie personnelle.  Changement de carrière, formation pour devenir naturopathe et enseignante de yoga. Quitter sa région natale pour un endroit où elle n'a aucun repère...  Après 9 années dans un travail qui ne lui procurait aucun sens, elle décide de tout bouleverser sans y aller de main morte comme on dit ! Mais à la clé... elle s'est brûlée les ailes.  Au programme de cet épisode :  Je t'invite à rejoindre ma conversation avec Céline qui nous explique son parcours de reconversion, son burn out de la vie mais aussi et surtout toutes ses clés pour t'éviter à toi aussi peut-être cet épuisement profond.  Belle écoute♥︎ ------------------------------- Pour me contacter : https://hygiene2vie.fr/contactez-votre-coach-naturopathe-hygiene-2-vie/   Recevoir la Lettre mensuelle d'Hygiene2Vie : https://hygiene2vie.fr/lettrehygiene2vie/  Pour me soutenir : https://fr.tipeee.com/hygiene2vie

Con la reattività di un elefante che reagisce a una mosca che si posa sulla schiena, siamo qui a parlare finalmente di quello che da mesi è diventato un trending topic, dopo essere stato per molto più tempo un software underground conosciuto da pochi e usato da ancora meno: Mastodon! In questo episodio parliamo quindi di fediverso, e lo facciamo non con gente a caso, ma con i mantainer di alcune delle principali istanze Mastodon italiane.Con: Edoardo Dusi, Paolo Mainardi, Fabio “Kenobit” Bortolotti, Carlo Gubitosa e Collettivo Bida/* Link */https://mastodon.bida.im/abouthttps://livellosegreto.it/abouthttps://sociale.network/abouthttps://joinmastodon.org/https://pleroma.social/https://join.misskey.page//* Newsletter & Telegram */https://landing.sparkfabrik.com/continuous-delivery-newsletterhttps://t.me/continuous_delivery

Nicoletta Bortolotti"Un giorno una donna"Harper Collinshttps://www.harpercollins.it/Ha detto che uomini e donne sono uguali e che “una donna intelligente riesce a far di tutto e anzi gli uomini sarebbero molto irritati se una donna ne sapesse più di loro”. Ha detto che bisogna fare studiare le bambine e se solo le donne avessero fatto i libri... Ha detto che le donne non provano piacere a essere stuprate, come molti credono, ma subiscono un dolore senza pari. Lo ha detto un giorno in cui Parigi era un tempo più che un luogo, e l'anno 1405 era un luogo più che un tempo. Lo ha detto nel Medioevo insanguinato dalla Guerra dei cent'anni tra Francia e Inghilterra.Davanti a tutta la corte francese, a re e nobili. Christine de Pizan, nata in Italia, prima storica donna, prima editor, poetessa e scrittrice. Donna. Nicoletta Bortolotti ricostruisce la sua vita, che, dopo un'infanzia meravigliosa al seguito del padre divenuto astronomo reale a Parigi, fu colpita da lutti e rovesci che la lasciarono, giovanissima, vedova e madre. Il risultato è un libro meraviglioso che da un lato sembra provenire dal passato, a partire dalla forma epistolare scelta, che tanti capolavori ha regalato alla letteratura, e che qui si incarna nelle lettere tra una madre e una figlia. E dall'altro è assolutamente moderno. Perché molte delle conquiste sognate da Christine si sono verificate solo in anni recenti, e altre si stanno verificando adesso, o devono ancora farlo.Con Un giorno e una donna Nicoletta Bortolotti ha scritto un romanzo importante, che è al tempo stesso un'opera di grande valore letterario in grado di far rivivere le passioni e i sentimenti di un'epoca, un'opera di grande valore storico nella ricostruzione perfetta, per quanto immersa nell'immaginazione romanzesca, della vita e dell'opera di Christine de Pizan, e di valore etico, perché l'esempio di Christine possa servire da guida in questi anni non sempre facili.IL POSTO DELLE PAROLEAscoltare fa Pensarehttps://ilpostodelleparole.it/

This week on the show we welcome Steve Bortolotti, General Manager of the IMSA winning team Pfaff Motorsports! You probably know the Pfaff livery even if you don't follow IMSA racing since they have the best looking Porsche on the track in it's clearly Canadian plaid wrap. Steve tells us all about the high and lows of racing, modding his Time Attack RX8, and a whole lot more. We can't wait to see what Pfaff does in 2023 in the new 992!

In this episode, Luca presents the first travel summit dedicated to the transition to Web3 together with Antonio Bortolotti, founder of the VRWS. Speeches, panels and workshops to help the industry upgrade to the new Web. The Web3 in Travel Summit is in Porto, Portugal on the 14th of September 2022. https://web3intravel.com https://vacationrentalworldsummit.com

Die van der Linde Brüder schreiben DTM-Geschichte auf dem Nürburgring. Als erstes Brüderpaar sicherten sich Sheldon und Kelvin van der Linde jeweils einen Platz auf dem Podium. Zwar verzögerte sich das Rennen am Samstag aufgrund des Nebels um fast 5 Stunden, doch das Rennen war dadurch um so dramatischer. Der Kontakt zwischen Fraga und Bortolotti war neben dem Doppelsieg der van der Linde Brüder das Thema am Samstag. Der Lamborghini Pilot entschuldigte sich direkt via Interview und auch beim Brasilianer, doch Frag äußerte berechtigterweise Unverständnis für diese unrühmliche Aktion. Am Sonntag ging es für den GRT-Grasser Piloten zwar nach der 5 Platz Gridstrafe nach vorne, doch beim Kampf um P4 mit Kelvin van der Linde krachte es schon wieder und er lässt damit auch am Sonntag wichtige Punkte liegen. Kritik gab es am Sonntag von René Rast und Co. beim Thema Strafe. Die Rennleitung rund um Scot Elkins wird aufgrund von zu wenigen harten Strafen kritisiert. Auch fehle es am Respekt zwischen den Fahrern, die wohl kaum mehr vorhanden ist. Alles Weitere zur DTM gibt es im ersten Teil der Episode. Im zweiten Teil haben wir die IMSA und den Porsche Mobil 1 Supercup für euch im Programm und dort blicken wir auf das Wochenende der beiden Meisterschaften zurück. Auch gibt es eine Vorschau auf das kommende GTWCE Endurance Rennen auf dem Hockenheimring an diesem Wochenende. +++ Hinweis +++ Wir unterstützen die Spendenaktionen für Flüchtende des Kriegs aus der Ukraine. Mit unserem Unterstützungspartner 2GETHER Spenden wir alle Werbeeinnahmen für die Menschen in der Ukraine. Mehr Infos und Spenden unter: 2gether.gg (Betterplace.org) +++ Werbung +++ Der GT Talk auf meinsportpodcast.de wird dir präsentiert von Virtual Racing School. Alle Informationen zu Hardware und zu 1:1 Coaching unter  virtualracingschool.com/ Folgt diesem Podcast auf Spotify, Audio Now oder in deiner Podcast-App der Wahl.   +++Social Media+++ Linktree Facebook  Twitter  Instagram  Moderation: Luca Storms Redaktion: Helmut Storms und meinsportpodcast.de Du möchtest deinen Podcast auch kostenlos hosten und damit Geld verdienen? Dann schaue auf www.kostenlos-hosten.de und informiere dich. Dort erhältst du alle Informationen zu unseren kostenlosen Podcast-Hosting-Angeboten.

Die van der Linde Brüder schreiben DTM-Geschichte auf dem Nürburgring. Als erstes Brüderpaar sicherten sich Sheldon und Kelvin van der Linde jeweils einen Platz auf dem Podium. Zwar verzögerte sich das Rennen am Samstag aufgrund des Nebels um fast 5 Stunden, doch das Rennen war dadurch um so dramatischer. Der Kontakt zwischen Fraga und Bortolotti war neben dem Doppelsieg der van der Linde Brüder das Thema am Samstag. Der Lamborghini Pilot entschuldigte sich direkt via Interview und auch beim Brasilianer, doch Frag äußerte berechtigterweise Unverständnis für diese unrühmliche Aktion. Am Sonntag ging es für den GRT-Grasser Piloten zwar nach der 5 Platz Gridstrafe nach vorne, doch beim Kampf um P4 mit Kelvin van der Linde ...Du möchtest deinen Podcast auch kostenlos hosten und damit Geld verdienen? Dann schaue auf www.kostenlos-hosten.de und informiere dich. Dort erhältst du alle Informationen zu unseren kostenlosen Podcast-Hosting-Angeboten. kostenlos-hosten.de ist ein Produkt der Podcastbude.Gern unterstützen wir dich bei deiner Podcast-Produktion.

In this episode of Vacation and Short-Term Rental Titans, Leo Walton (co-founder of SUPERHOG) has the pleasure of talking to Antonio Bortolotti, the Host of the Vacation Rental World Summit. First held in 2014, the Vacation Rental World Summit is a highly productive, engaging, and truly unique, memorable live event and online platform that allows viewers to learn quickly, adopt highly effective practices and improve their Vacation Rental Business overall performance. The live event adds an unforgettable layer of personal interaction with the most forward-thinking and inspiring peers in the industry. Antonio tells us about this year's VRWS lineup and the topics that will be discussed. With some fascinating talks scheduled, this year is certainly not one to miss! Antonio explains what sets VRWS apart from other vacation rental events and how the format has been optimized to allow property managers of different sizes and different geographical territories to share their experiences and help each other develop.

Pfaff Motorsports is one of the most successful sportscar racing teams in North America over the past decade. The team has led over 5,000 laps, achieved 36 pole positions, amassed 35 race wins and seven championships, a record of achievement capped by the 2021 IMSA WeatherTech GTD championship and a win at the 2022 Rolex 24 at Daytona.

On today's episode, John and Mateo sit down with Antonio Bortolotti, the founder of Vacation Rental Secrets and host of the Vacation Rental World Summit. Antonio's start in the industry is unlike any other we have spoken to. A commercial airline pilot for almost 4 years up until the tragic event of 9/11 where he then developed a fear of flying. Looking for an exit and where to go next he began purchasing short-term rentals. In 3 years, he purchased and brought three dilapidated properties to profit. Antonio was self-taught in every aspect of vacation rentals and began building websites, consulting, and speaking at HomeAway events where he would share his insights with property managers. Antonio has always found joy in helping others and providing value wherever he can so he created his own industry event. The first summit was virtual where he attracted 15,000 attendees in just 3 days spanning 49 countries. Ever since then he's been sharing his secrets about the industry with property managers all over the world. Such a positive man and an interview you do not want to miss!

On today's episode, John and Mateo sit down with Antonio Bortolotti, the founder of Vacation Rental Secrets and host of the Vacation Rental World Summit. Antonio's start in the industry is unlike any other we have spoken to. A commercial airline pilot for almost 4 years up until the tragic event of 9/11 where he then developed a fear of flying. Looking for an exit and where to go next he began purchasing short-term rentals. In 3 years, he purchased and brought three dilapidated properties to profit. Antonio was self-taught in every aspect of vacation rentals and began building websites, consulting, and speaking at HomeAway events where he would share his insights with property managers. Antonio has always found joy in helping others and providing value wherever he can so he created his own industry event. The first summit was virtual where he attracted 15,000 attendees in just 3 days spanning 49 countries. Ever since then he's been sharing his secrets about the industry with property managers all over the world. Such a positive man and an interview you do not want to miss! Learn more about your ad choices. Visit megaphone.fm/adchoices

As recentes tensões entre apoiadores da governadora Izolda Cela e do ex-prefeitos Roberto Cláudio devem fazer o grupo Ferreira Gomes alterar uma tradição na definição de candidaturas: deixar essa escolha para o prazo final das convenções partidárias. Foi assim com Camilo Santana (PT) em 2014, foi assim com José Sarto (PDT) em 2020. A avaliação é que as disputas internas já passaram do ponto, e o melhor é definir logo o nome para evitar fissuras ainda mais profundas. É realmente o melhor a se fazer? O PDT sairá unido e fortalecido desse processo? O que deu errado nesse planejamento eleitoral? Para responder a essas e outras perguntas, o episódio #190 do podcast Jogo Político recebe os jornalistas Guálter George, Ítalo Coriolano e Plínio Bortolotti.

Aujourd'hui, j'accueille Alex Bortolotti. C'est un créateur de site via Wordpresse. Il a créé le site WPMarmitte.com qui est consacré à Worpress. De plus, il aide à être autonome sur Wordpress en tant que formateur sur le site Wpchef.fr. Dans ce podcast, il nous explique cette passion pour Wordpress ainsi que son parcours professionnel. Si vous avez envie de découvrir un peu plus sur lui, il y a son site internet alexborto.com et il fait des vidéos youtube alexborto.

Neste episódio apresentado pelo nosso Head Nippur Direct, Renan Hack, conversamos com nosso assessor de investimentos, Rafael Bortolotti.

Nicoletta Bortolotti"Disegnavo pappagalli verdi alla fermata del metrò"La storia di Ahmed MalisGiunti Editorehttps://www.giunti.it/Una storia di riscatto, solidarietà e tenacia: perché solo quando ci crediamo fino in fondo, i sogni possono diventare realtà. Ahmed Malis, un ragazzo di origine egiziana, figlio di genitori immigrati a Milano negli anni Ottanta, ama disegnare ed è un vero prodigio autodidatta. La sua famiglia, però, non ha abbastanza disponibilità economica per mandarlo all'Accademia d'arte e sogna per lui un futuro solido, non certo da artista. Ahmed frequenta insieme ai suoi fratelli il centro di aggregazione giovanile CDE Creta, molto attivo nel quartiere milanese del Giambellino. Proprio qui, grazie all'iniziativa di un educatore che più di tutto vuole dare una chance a questi adolescenti spesso allo sbando, Ahmed riesce a pubblicare i suoi disegni sul Corriere.it e a realizzare il suo sogno. I disegni della copertina e degli interni sono di Ahmed Malis.Nicoletta Bortolotti nasce in Svizzera, ma vive in Italia. Laureata in pedagogia, redattrice Mondadori, autrice per ragazzi e per adulti, incontra studenti nelle scuole di tutta Italia e della Svizzera. Ha pubblicato per Sperling & Kupfer Il filo di Cloe ed E qualcosa rimane (premio Carver e Leonforte); per Mondadori Sulle onde della libertà; per Einaudi ragazzi In piedi nella neve (premio Gigante delle Langhe e premio Cento), Oskar Schindler Il Giusto e La bugia che salvò il mondo. Per Harper & Collins Chiamami sottovoce (premio Alvaro Bigiaretti e Giuditta), grazie al quale è stato girato un docufilm per Rai 3.IL POSTO DELLE PAROLEascoltare fa pensarehttps://ilpostodelleparole.it/

Na esteira das comemorações pelos 94 anos do O POVO, está sendo lançado o projeto Pra Começo de Conversa, uma série de diálogos em formato audiovisual em que especialistas apresentam panoramas sobre temas diversos, de interesse da sociedade. No primeiro deles, intitulado "Não é Fake News, é Desinformação", os jornalistas Plínio Bortolotti e Daniela Nogueira, ambos do O POVO, e Sérgio Lüdtke, editor-chefe do Projeto Comprova, falam sobre os processos de engenharia da informação, disseminação de notícias falsas, a importância da checagem dos fatos e o papel do jornalismo nesse cenário de pós-verdade. A produção está disponível na plataforma multistreaming OP+.

Problemas com aplicativo de votação levaram ao adiamento do fim das prévias do PSDB, já envolvidas em enorme disputa interna. Arthur Virgílio (AM), Eduardo Leite (RS) e João Doria (SP) se enfrentam, com favoritismo deste último. Com o fiasco no processo até aqui, movimentos dentro do partido cogitam a hipótese de nem lançar candidato e apoiar outro nome. Um dos pré-candidatos, Virgílio aponta influência do deputado Aécio Neves, que teria interesse em tumultuar o processo e aproximar a sigla de Bolsonaro. No meio desse conflito, qual o rescaldo da crise na votação do PSDB? Que rumo tomará o partido? Qual espaço conseguirá ter na eleição e no futuro da política brasileira? E como a chamada "terceira via" será afetada. Este é o tema do Jogo Político episódio 161. Participam do Jogo Político os jornalistas do O POVO Plínio Bortolotti, Carlos Holanda e Érico Firmo

Join Matthew and Brian from the 2021 Vitur Summit with Antonio Bortolotti, host of the Vacation Rental World Summit. Antonio emphasizes the importance of virtual concierge and home automation solutions and talks about how they impact the guest experience. He also shares the new format of the Vacation Rental World Summit and how it brings property managers and owners together from all over the world. Learn more about your ad choices. Visit megaphone.fm/adchoices

Presentazione di Laura Pisana

S1 Claire Bortolotti worked as a paramedic before joining the Canadian Armed Forces as a Medical Technician. Looking for more action and excitement, she completed a very difficult selection followed by a year long course to become a Clearance Diver in the Royal Canadian Navy. She has also competed internationally as a swimmer representing Canada at the World Military Games. ---------- instagram.com/shootlikeagirlpodcast/ shootlikeagirlpodcast@gmail.com

Tim, Birra Moretti, Gamper, Bortolotti, Bernabeu, Pirelli, Berlusconi. E' estate, sono finiti Europei e Copa America, ma noi vogliamo sempre calcio: ridateci i trofei estivi!

Abitiamo nella nostra vigna dal 1987 e non abbiamo esitato a fare scelte radicali.La vite, gli alberi, l'erba, i fiori e gli animali fanno parte della nostra famiglia, per questo vogliamo vivere in armonia con la natura: abitanti – viticoltori ne rispettiamo ogni manifestazione. Fin da subito abbiamo aderito al progetto “Vino del parco” di Giorgio Celli, alla fine degli anni '80 e nel 1992 siamo arrivati all'agricoltura biologica.Dal 2000 le nostre uve vengono trasformate in modo naturale perché siano piena espressione della natura. La nostra azienda si trova Ponte Ronca (Zola Predosa) nella fascia collinare a monte della S.S. Bazzanese in un'amena posizione affacciata sulla pianura. Nelle serene giornate invernali lo sguardo spazia fino a scorgere le Prealpi coperte di neve. La natura del terreno e l'esposizione ne fanno una zona vocata alla coltura della vite. L'azienda è costituita da sei ettari di vigneto, dalla cantina e dalla struttura abitativa su un'area cortiliva di circa 2000 mq.Le strutture originarie sono della fine dell'800, ristrutturate negli anni 70-80, la cantina è di nuova costruzione nel rispetto dell'architettura presistente.Il vigneto è composto dai vitigni Pignoletto, Sauvignon e Barbera dal 1992 pratichiamo l'agricoltura biologica. Il vigneto è circondato da una siepe di essenze autoctone quali roverella, acacia, biancospino, rosa canina, prugnolo con inserimenti recenti di olivello spinoso, viburno ecc. Questo per favorire l'habitat di animali e in maniera particolare di insetti utili.Ai bordi nel vigneto sono stati piantati alberi da frutto: susine, pere, mele, noci, ulivi ai quali aggiungeremo varietà antiche di piante da frutto che non necessitano di particolari interventi antiparassitari.Nelle zone a prato del vigneto crescono erbe spontanee come menta, mentuccia, radicchi e cicorie e altre essenze aromatiche coltivate come salvia, timo e rosmarino

Die sozialen Medien sind sowohl beruflich als auch privat ein wichtiger Bestandteil von Leas Alltag. Gemeinsam unterhalten wir uns über die Schattenseiten der Onlinewelt und berichten zudem über unsere eigenen Schwierigkeiten. Am Ende gibts für dich auch noch Ideen für eine "gesunde" Nutzung der Plattformen Instagram, Facebook, TikTok und Co.  Abonniere diesen Podcast, wenn dir diese Episode gefallen hat. Mehr zu Lea: ► Instagram: https://www.instagram.com/leabortolotti/ ► TikTok: vm.tiktok.com/ZMe8m1ucx - Willkomen bei The Better Version. Gemeinsam kreieren wir eine bessere Version von uns selbst und wachsen zu einer Persönlichkeit heran, die in der Lage ist, all ihre Ziele zu erreichen. Let`s connect: ► Instagram: https://www.instagram.com/philip.pircher ► Facebook: https://www.facebook.com/philippircher ► LinkedIn: https://www.linkedin.com/in/philippircher Teile diesen Podcast und hilf deinen Freunden dabei, eine bessere Version von sich selbst zu kreieren: https://anchor.fm/philippircher Ich freue mich, diesen Weg gemeinsam mit dir zu beschreiten, Philip Pircher

Lamborghini kicks off International GT Open season with victory and points lead Schandorff and Beretta lead VS Racing one-two in second Paul Ricard race Lamborghini also claims GT Open Am class one-two result Podium for factory drivers Bortolotti and Costa in GT Masters opener at Oschersleben Lamborghini recorded a sensational one-two finish on the opening ...

IL BENVENUTO IN REDAZIONE A ELENA BORTOLOTTI

IL BENVENUTO IN REDAZIONE A ELENA BORTOLOTTI

Wir hatten diese Woche einen sehr "schnellen" Gast. Unglaublich, was Mirko Bortolotti schon alles in seinem jungen Leben erreicht hat. Zudem ist sein Wechsel von Audi zu Lamborghini natürlich eine häufige Frage von unseren Usern gewesen. Was Marc und Mirko in einem Restaurant am Nürburgring passiert ist, wird am Ende aufgeklärt... - also hört rein und Wir wünschen Euch einen guten Rutsch ins Jahr 2021! Bleibt gesund. hdgdl Carrie und Marc

Alexandre Bortolotti est formateur en ligne et fondateur de WP Marmite, le plus gros blog français pour apprendre à créer un site Wordpress. Alexandre passe sur le podcast pour la troisième fois. En février 2016, il nous expliquait comment changer une stratégie marketing qui ne fonctionne pas. En juin 2018, il recrutait ses 6 premiers employés pour faire de WP Marmite un monstre. Ce que vous allez apprendre : - Point de bascule : ce qui empêche la croissance de 90% des formateurs - S’exporter aux US : pourquoi être numéro un en France ne suffit pas - Comment gérer une équipe de 10 personnes qui ne se réunissent qu’une fois par an - Pourquoi Alexandre a enfin recruté son premier CDI dans son équipe de 9 freelances - Pourquoi faire du personal branding quand sa boîte cartonne déjà - La danse du fondateur : comment équilibrer son temps entre création, gestion et vie perso La page de l’épisode (et les ressources) : https://marketingmania.fr/alexandre-bortolotti-3/ Le premier épisode avec Alexandre en février 2016 : https://marketingmania.fr/alexandre-bortolotti/ Le second en juin 2018 : https://www.youtube.com/watch?v=h_tzYP9qNDs *** Le site d’Alexandre Bortolotti : https://wpmarmite.com/ La chaîne WP Marmite : https://www.youtube.com/user/WPMarmite La chaîne Alex Borto : https://www.youtube.com/user/alexbtroyes Construisez une audience qui achète : https://marketingmania.fr/audience Devenez un entrepreneur productif : https://marketingmania.fr/productif/ Le Guide du Copywriting E-commerce : https://marketingmania.fr/ecom Ma newsletter du lundi : https://marketingmania.fr/mix Commandez mon livre : https://marketingmania.fr/empire Écoutez-le gratuitement avec l'essai Audible : https://marketingmania.fr/go/empire-audiobook Posez votre question à faq@marketingmania.fr

49ers, une production italienne de Bortolotti, est en quelque sorte l'alter ego du groupe eurodance Cappella. Voici le parcours musical des 49ers reconnus à la fois pour leur sampling abusif mais efficace et leurs interprètes féminines au talent vocal indéniable! Bonne écoute! Retrouvez Eurodance Story sur - Soundcloud : https://soundcloud.com/eurodance-story - Apple Podcast : https://itunes.apple.com/fr/podcast/eurodance-story/id1446532245 - Podcloud : https://podcloud.fr/podcast/eurodancestory - Deezer : https://www.deezer.com/en/show/363652 - PlayerFM : https://player.fm/series/2469797 - Spotify: https://open.spotify.com/show/56NAqZG3NAlTA7R9BYNPfS - TuneIn : https://tunein.com/podcasts/Music-Podcasts/Eurodance-Story-p1186379/ - Stitcher : https://www.stitcher.com/podcast/eurodance-story - Google Podcast : https://www.google.com/podcasts?feed=aHR0cHM6Ly9ldXJvZGFuY2VzdG9yeS5sZXBvZGNhc3QuZnIvcnNz - Pocket Casts : https://pca.st/xV9i - Castbox : https://castbox.fm/channel/Eurodance-Story%7D-id1956149 - et sur toutes les autres plateformes de podcast : Podcast Addict etc.... Vote pour tes artistes préférés : https://forms.gle/RCV343AhxiVGMskR6 Eurodance Story est aussi sur : Facebook : https://www.facebook.com/EurodanceStory Twitter : https://twitter.com/Eurodance_Story Instagram : https://www.instagram.com/eurodancestory/ Twitch : https://www.twitch.tv/hakim1976 Discord : https://discord.gg/J8sWFav Me contacter sur Twitter : @MaadHakim

O podcast Jogo Político chega ao episódio 100. Os jornalistas do O POVO elegem quem foram as personagens mais importantes, mais influentes destes mais de dois anos de programa. Apontam também quais os fatos políticos mais marcantes deste período. E fazem também as apostas para os rumos do País e do Estado nos próximos dois anos. O que se projeta? Quem deve se fortalecer? Quem pode entrar em decadeência? Quais as tendências. O programa especial é também o primeiro desde o início da campanha eleitoral. Então, os jornalistas analisam os primeiros passos da campanha e dão as primeiras impressões. O Jogo Político 100 tem a participação de Guálter George, editor de Política e colunista do O POVO, Tânia Alves, editora, coordenadora e colunista, Carlos Mazza, repórter e colunista, e Érico Firmo, editor e colunista. Neste episódio especial hpá também as participações especiais de Plínio Bortolotti, Eliomar de Lima, João Marcelo Sena, Carlos Holanda e Henrique Araújo.

In episode #22 of the MoneySaver Podcast, we chat with Dan Bortolotti, blogger, financial planner and podcast host of the Canadian Couch Potato about exchange traded funds (ETFs), index investing, passive vs active investing and all-in-one ETFs. Questions Asked: 0:56 Tell us a little bit about what got you interested in the couch potato approach to investing. 3:02 You won a Globe and Mail award for The Couch Potato blog. 3:50 Can you explain index investing?  Why is it lower cost? What is the difference between passive and active? 7:58 What has held index funds back? 11:59 What made you decide to take the leap from being a full time journalist to a financial advisor? 17:18 What do you think about the growth in actively managed ETFs? 20:54 What do you think of the advent of robo-advisors as a way to fill the market gap for individuals who do not want to do the work on their own? 27:02 The newest product is the all in one ETF portfolio priced really low which seems to give you a lot of advantages of a robo-advisor.  What do you think of those? 36:00 What are three tips that are essential for Canadians to consider when they're thinking about investing.

Dr. Carolyn Lam:               Welcome to Circulation on the Run, your weekly podcast summary and backstage pass to the journal and its editors. I'm Dr. Carolyn Lam, associate editor from the National Heart Center and Duke National University of Singapore.                                                 Our feature discussion this week centers on the temporal changes in natriuretic peptides preceding heart failure hospitalizations and patients at high risk. Data that are really novel and have implications for the way we perhaps monitor and categorize these high risk patients. Well, more soon right after these summaries.                                                 The first original paper this week provides the first epigenome-wide association study in patients with heart failure. Now, epigenetics refers to biochemical DNA modification such as methylation of gene bodies, and post-translational modification of histones, which is increasingly recognized to play a crucial, regulatory interface between genes, environment, and the transcriptome.                                                 The lack of availability of myocardial specimens from patients has been a major roadblock for elucidating the impact of such epigenetic changes on complex cardiovascular traits. However, in today's paper from first author, Dr. Meder, corresponding author, Dr. Katiz and colleagues from University of Heidelberg, Germany. The authors performed the first multi-omic study in myocardial tissue and blood of patients with dilated cardiomyopathy compared to controls.                                                 They detected 59 epigenetic loci that are significantly associated with dilated cardiomyopathy, with three of them reaching epigenome-wide significance. 29 of these loci could be replicated in independent cohorts and authors further linked a subset of 517 epigenetic loci with dilated cardiomyopathy and cardiac gene expression.                                                 Finally, they identified distinct epigenetic methylation patterns that are conserved across tissues. Thus representing novel, epigenetic biomarkers for heart failure.                                                 The next study is the first to assess a diagnostic and prognostic value of cardiac myosin binding protein-C in patients presented with possible acute myocardial infarction or AMI. Cardiac myosin binding protein-C is a cardiac restricted protein that is more abundant than the cardiac troponins and is released more rapidly following AMI.                                                 In today's paper, first author, Dr. Kaya, corresponding author, Dr. Marber and colleagues from the Rayne Institute In St. Thomas's hospital in London evaluated cardiac myosin binding protein-C as an adjunct or alternative to cardiac troponins in the early diagnosis of AMI in 1,954 unselected patients presenting to the emergency department with symptoms suggestive of AMI.                                                 The final diagnosis of AMI was independently adjudicated in 340 patients. The authors found that concentrations of cardiac myosin binding protein-C at presentation were significantly higher in those with versus without an AMI. The discriminatory power for AMI quantified by the area under receiver operating curve was comparable for cardiac myosin binding protein-C to high sensitivity cardiac troponins T and I, and even superior to standard sensitivity cardiac troponin I. The use of cardiac myosin binding protein-C more accurately classified patients with a single blood test and to rule out or rule in categories in early presenters, meaning those with chest pain of less than three hours.                                                 The improvement in rule in or rule out classification with cardiac myosin binding protein-C was larger compared with higher sensitivity cardiac troponins T and I. Finally, cardiac myosin binding protein-C was superior to high sensitivity and standard troponin I and similar to high sensitivity cardiac troponin T at predicting death at three years. Thus in summary, this paper shows that cardiac myosin binding protein-C at presentation provides discriminatory power comparable to high sensitivity troponins T and I in the diagnosis of AMI and may perform favorably in patients presenting early after symptom onset.                                                 The next paper describes the discovery of a novel candidate cardiomyopathy or arrhythmia gene. First author, Dr. Barryfield, corresponding author Dr. McNally from Center of Genetic Medicine in Chicago and colleagues studied a family with dilated cardiomyopathy and associated conducted system disease in whom prior clinical cardiac gene panel testing was unrevealing. Whole genome sequencing however, identified a premature stop codon in the gene encoding a novel myo filament component, the myosin binding protein-H-like.                                                 Having identified this gene, they turned to experimental approaches. The myosin binding protein-H-like gene was found to have high atrial expression with low ventricular expression. The truncated protein failed to incorporate into the myo filament. Human cell modeling demonstrated reduced expression of the mutant allele. Heterozygotes and nullumites exhibited a reduction in fractional shortening and increased diastolic ventricular chamber size, aberrant atrio-ventricular conduction and an increased rate of arrhythmia associated with the expression of the myosin binding protein-H-like in the atria, as well as in discrete puncta throughout the right ventricular wall and septum.                                                 These findings therefore support that myosin binding protein-H-like truncations may increase the risk for human arrhythmias and cardiomyopathy.                                                 Transplantation of cells into the infarctant heart has significant potential to improve myocardial recovery. However, low efficacy of cell engraftments still limits the therapeutic benefit. In today's paper, authors describe a method for the unbiased, in-vivo selection of cytokines that may improve Mesenchymal stromal cell engraftment into the heart. In this paper from first author, Dr. Bortolotti, corresponding author Dr. Giacca, and colleagues from University of Trieste in Italy, an arrayed library of 80 secreted factors were individually cloned into adeno-associated viral vectors.                                                 Pools from this library were then used for the batch transduction of bone marrow derived Mesenchymal stromal cells ex-vivo, followed by intra myocardial cell administration in normal and infarctant mice. Three weeks after injection, the vector genomes were recovered from the few persisting cells, and identified by sequencing DNA barcodes that were uniquely labeled for each of the tested cytokines.                                                 Using this novel, competitive, engraftment screening methodology, the authors identified that the most effective molecule was cardiotrophin-1 a member of the IL-6 family. Intra cardiac injection of Mesenchymal stromal cells preconditioned with cardiotrophin-1 preserved cardiac function and reduced infarct size parallel to the persistence of the transplanted cells in the healing hearts for at least two months after injection. Thus, preconditioning with cardiotrophin-1 might represent an efficient manner to improve the currently poor cell retention in patients treated with Mesenchymal stromal cell therapy.                                                 The final paper presents results of the early myo trial, a non-inferiority trial comparing a pharmacoinvasive strategy with half-dose alteplase versus primary PCI in patients with STEMI, presenting six hours or less after symptom onset but with an unexpected PCI related delay.                                                 First author, Dr. Poole, corresponding author, Dr. Hua and colleagues from Shanghai Jiao Tong University in China randomized a total of 344 patients from seven centers to a pharmacoinvasive arm or a primary PCI arm. They found that pharmacoinvasive strategy was non-inferior to primary PCI for the primary endpoint of complete epicardial and myocardial reperfusion after PCI defined as TIMI flow grade 3, TIMI myocardial profusion grade 3, and ST-segment resolution of more than 70%.                                                 There was no significant differences in the frequency of the individual components of the combined endpoint. Infarct size and left ventricular ejection fraction were similar in both groups and there was no significant differences in 30-day rates of total death, re-infarction, heart failure, major bleeding events, or intracranial hemorrhage. However, minor bleeding was observed more often in the pharmacoinvasive group.                                                 Thus the authors concluded that a pharmacoinvasive approach with reduced dose alteplase seems to offer effective and safe reperfusion in low-risk patients with STEMI with an unexpected PCI related delay. Further large, randomized control trials powered for clinical endpoints are needed.                                                 Well, that wraps it up for your summaries. Now for our feature discussion.                                                 The measurement of natriuretic peptides BNP, NT-proNP have certainly become the cornerstone of heart failure management. We measure these levels by guidelines in patients who are presenting with symptoms and suspected heart failure, in patients who are hospitalized. We measure them for prognostication purposes at discharge. However, what we don't really know is how the preceding changes in natriuretic peptides may precede heart failure hospitalization in patients who are at high risk of developing heart failure.                                                 For example, patients with a recent coronary event or type-2 diabetes. And this is the very subject of our feature paper today, and I am so pleased to have the corresponding author of today's paper which is really a research letter. Dr. Brian Claggett from Brigham and Women's Hospital as well as Dr. Biykem Bozkurt who's our senior editor from Baylor College of Medicine.                                                 Welcome both, and maybe I could start, Biykem could you let us know, what are the unanswered questions in heart failure relating to natriuretic peptides and how do you see this paper falling in, clinically? Dr. Biykem Bozkurt:        Carolyn, this is a wonderful I think prelude to perhaps preventing heart failure events. And as you are aware, we in the recent year changed our guidelines at the ACC, AHA, and the HFSA incorporating screening high risk patients for development of incident heart failure. And the study that resulted in this consideration was a STOP-HF trial which was utilizing natriuretic peptides in high risk patients to determine whether their closer follow up in a multidisciplinary fashion would result in earlier detection and prevention of heart failure, and which it did.                                                 And this study I think is straddling the concept of high risk or stage A or B patients because they are individuals who have had heart attacks, coronary events, and they have type-2 diabetes so they are definitely high risk. And doing natriuretic peptides as an outpatient, whether that would predict the heart failure hospitalizations.                                                 And in essence I think it's a good concept. Perhaps the challenging concepts are how often should we screen our patients, and what will be the threshold of the rise that would potentially make us act in either earlier diagnostic strategies, or management strategies. I think those are the two unanswered questions that remains.                                                 How are we gonna screen our patients? Our high risk patients to determine when they are developing heart failure before they become symptomatic? So, what threshold are we going to use? Dr. Carolyn Lam:               That is a perfect set up. I just wanted to add as well in addition to STOP-HF there was the PONTIAC study in diabetics which is very relevant to today's paper that also sort of used NT-proBNP to risk stratify patients for prevention of heart failure. But neither of these studies talked about the temporal changes in natriuretic peptides. And I think a lot of the reason for that is, is that the methods, I mean the statistical methods to do that sort of thing are mind-blowing.                                                 And so Brian, could you now please share with us what you did, the methodology and basically what you found before we discuss the two questions that Biykem brought up? Dr. Brian Claggett:           What was really interesting is the method that we came up with to look at these questions. It's something that we like to believe will be generalizable and can be used in other scenarios and for other biomarkers. But the idea that we have is that we are always used to thinking about the design of a clinical trial as being very regimented. So, you see a patient once at baseline, and then maybe six months later, and then maybe six months after that, and so on. And so it's hard to know what's going on, on a day to day or week to week basis.                                                 But if you think backwards, and you think backwards from the time of any sort of event, because those events whether they're hospitalizations or MIs or death, they happen not on that same schedule. And so odds are at the end of a trial, you had a patient who came to a scheduled visit and then had an event the next day. And you probably had a patient who came in for a visit two days before an event, and another patient who came in a week before an event. So if you start thinking on that time scale, you can piece together all these different time frames when you do have data collected and try to reconstruct something that looks like an actual continuous natural history of what that biomarker would have looked like over say a two year period, if it had been measured continuously. Dr. Carolyn Lam:               So, tell us what you found. First of all, let's just make sure that everyone knows you were looking at the ELIXA cohort, right? Dr. Brian Claggett:           Yes, the data that we had available for this analysis comes from the ELIXA trials, it was 6,068 patients all with type-2 diabetes and a recent ACS event. Recent meaning within the last 180 days. And they were randomized placebo versus a diabetes drug, lixisenatide. And they were followed up for cardiac outcomes.                                                 Beyond that, the natriuretic peptides were measure systematically at baseline, month 6, month 18, and month 24 in all patients who were participating in the trial. So this was the richest collection of a large number of patients being measured multiple times, systematically and not in just a sub-sample of the population. So, we felt like this was a great opportunity to learn something about what happens. What can you learn when you measure these natriuretic peptides over and over again.                                                 And even more interesting than that, the fact that this wasn't a heart failure trial meant that some of the patients already had heart failure at baseline. Other patients didn't have heart failure, but as the trial went on, they developed or were hospitalized for heart failure for the first time. And so we were able to also look at differences between patients experiencing their first heart failure, versus those with more long standing disease. Dr. Carolyn Lam:               And that was very, very unique methodology that you spoke about. And I fully agree that it's going to be used more. I am staring at your beautiful figure one right now. That really, really says it all. Could you walk us through the results? Dr. Brian Claggett:           Sure, I think our key finding is that, I guess no matter when you measure patients. Patients with a higher level of NT-proBNP, or a higher level of BNP at any given time are going to be at higher risk of developing heart failure in the future.                                                 But as we start looking at this as a temporal process, what we see is that there seem to be a noticeable acceleration in these increases, specifically in the last six months before development of heart failure. Or, before a hospitalization for heart failure. And that increase in the final six months seems to occur both in patients who had no prior history of heart failure and also in patients with a history of heart failure. So that six month window I think is something that we learned that we didn't necessarily know before. Dr. Carolyn Lam:               But, going back to Biykem's questions, do you think we have answers to how often we need to survey natriuretic peptides in these high risk patients and what threshold we need to act on? Dr. Brian Claggett:           I think both are very important. I think maybe the timing and the thresholds are somewhat separate questions. I think we're better able to answer the timing question. At the very least we can say that if dramatic changes are happening over a six month window that measuring patients only once every six months probably isn't enough. Whether that means it needs to be every three months, or two months, or one month, or something more than that, I think it's hard to know exactly what the right answer is. But I think we are confident in saying that things happen relatively quickly and we need to be measuring these things more frequently.                                                 As far as the question of thresholds, I think that's maybe even a more difficult question. Or even the idea of a threshold means that we think that there's some magic number and I am not sure that we know for sure what's more important, the absolute number or is it the ... if someone starts relatively low and that relatively low number doubles over the course of six months. That might still be prognostically just as important as someone who's been consistently edging just below or just about that threshold level.                                                 I'm not sure that we're confident enough to say that the changes, the speed of the changes, or the relative changes, or some absolute threshold is the most important thing to be paying attention to. But, I think where these two are related is the more ... that we can start to collect this data more frequently and be able to analyze it. I think that gives us a lot better chance of being able to successfully answer that question about thresholds. Dr. Carolyn Lam:               Indeed. Stuff for future work, huh? Biykem, what do you think? Dr. Biykem Bozkurt:        I wanted to point out two things from Brian's study which was quite interesting. One is the trajectory of the rise, or the delta changes in the natriuretic peptides was quite different in the patients with no history of heart failure compared to those with a history of heart failure. The trajectory, or the linear rise, or the delta changes were more prominent in the individuals with no history of heart failure. Probably intuitively expected so because their baseline levels are not as high as the individuals with history of heart failure.                                                 So, it almost gives the impression that maybe in low low risk, the screening or the frequency may need to be lower, and if low, then probably the likelihood of the rise may be less. But those individuals who, as you said, are edging upward, then maybe the frequency may need to be higher and there may be perhaps a linear rise or a more prominent rise about six months before the incident event.                                                 So, it's an interesting concept just to look at people's trajectories. But, as you said, probably individualization and monitoring or targeting may need to be individualized according to personal risk and other features. And one then wonders futuristically if this would be a concept that would be point of care testing maybe done by the patients similar to glucose monitoring. And in the event that we were to be able to carry the platform to self-test. Dr. Brian Claggett:           You're talking to a statistician, so I am always going to be in favor of collecting more data all the time. So I agree with that. Dr. Carolyn Lam:               Wow, what an insightful discussion. Thank you both for joining us on this podcast today.                                                 Ladies and gentlemen out there, you heard it right here in Circulation on the Run. Tune in again next week.