Podcasts about Bortolotti

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Best podcasts about Bortolotti

Latest podcast episodes about Bortolotti

Podcast – F1Weekly.com – Home of The Premiere Motorsport Podcast (Formula One, GP2, GP3, Motorsport Mondial)

…ON TODAYS PROGRAM…   FERNANDO AND THE HONDA CURSE, LAWRENCE STROLL SELLS ASTON MARTIN NAMING RIGHTS FOR 50 MILLION POUNDS. FERRARI ON THE OTHER HAND SHOW OFF NEW SPINNING REAR WING AND, LOOK VERY COMPETITIVE ! MCLAREN AND MERCEDES ARE NOT FAR BEHIND… RED BULL IS STILL A QUESTION MARK?…AND FERNANDO WILL NEED HIS CAMPING CHAIR AS THE GP2 ENGINE THAT FAILED HIM AT MCLAREN, THAT WENT KABLAMO IN THE INDY 500 AND LOOKS TO HAUNT ALONSO FOR ANOTHER LONG SEASON!! STAY TUNED FOR SOME GREAT ONE LINERS FROM MACHISMO… THIS WEEK'S NASIR HAMEED CORNER…MORE VINTAGE BANTER BETWEEN THE HOST AND NASIR…THIS WEEKS SPECIAL GUEST: MARCUS ERICSSON, MARTIN BRUNDLE, AND MIKI MONRAS DE ESPANA…! Indianapolis 500 Veteran Hucul Dies at 79   INDIANAPOLIS (Friday, Feb. 20, 2026) – Canadian driver Cliff Hucul, a veteran of three Indianapolis 500 starts in the late 1970s, died Feb. 17 on his farm in his native Prince George, British Columbia. He was 79. Hucul made three consecutive starts in “The Greatest Spectacle in Racing” from 1977-79. His best finish came as a rookie in 1977, 22nd in the No. 29 Team Canada McLaren/Offenhauser that Hucul bought after Johnny Rutherford drove it to victory in the 1976 “500.” Hucul completed 72 laps before being sidelined by gearbox problems. He qualified on Bump Day for that race despite touching the wall in practice the previous day and suffering two engine failures during the Month of May, a significant pitfall for his low-budget team. Hucul's best qualifying spot was 18th in 1979, his final “500” start. The small-town driver from northern British Columbia learned his craft by racing stock cars and modified sprint cars at local tracks. He then began racing modifieds and supermodifieds in the Pacific Northwest against drivers that included eventual Indianapolis 500 winner and INDYCAR SERIES champion Tom Sneva and his brother Jerry Sneva. Hucul made 24 total USAC and CART starts between 1977-81, with eight top-10 finishes. Hucul's best finish in the standings was 11th in 1979, when he started the season by placing fifth at Ontario Motor Speedway and a career-best fourth at Texas World Speedway. In 1996, Hucul became a paraplegic after an automobile accident when crossing black ice on a highway in British Columbia. Despite being confined to a wheelchair, Hucul remained active, managing his farm and mentoring many drivers in the area. He was inducted into the Prince George Sports Hall of Fame for his lifetime contributions to auto racing. Hucul is survived by his son, Kelly, and daughter-in-law, Sylvie; daughter, Michele, and many grandchildren. 2026 BAHRAIN TESTING - WEEK 1, DAY 3 MAX VERSTAPPEN “Looking at the test overall, the Team got in a good number of laps on the first day so we were happy with that. We completed a lot of things that we wanted to test with the new Power Unit and the car in general. Today it was a continuation of that plus also trying to explore a little bit more with the car; you go through so many test items that it continues to change and evolve with everything that you are testing. In general, it is all so new that we are still learning a lot, but the car was good. We also have new tyres, so we spent some time looking at different sets and understanding what we need to improve and be better at. With the power unit, looking at the laps we got on the board, the start that we have had is good. That's exactly what we wanted to do and it was not a given. Whether it will be enough to win races, we don't know, we will just focus on ourselves and try to do the best we can, but there is still massive room for improvement. Finally, with the car, we learnt a lot about what worked and what didn't. Our runs also gave us even more ideas for the afternoon with Isack and then for next week, where we can continue to try new things and different set ups.” ISACK HADJAR “The first week here in Bahrain has gone well. Of course, I had to wait a little before getting in the car after Barcelona, but once I did, we were able to put it to the test and really work through what we need ahead of next week and Melbourne. There are so many things to look at, but we're staying on track with our programme so far. True performance and pace are always hard to judge in pre-season, but we can be happy with the reliability we've had from the power unit this week. There are still things to work on in terms of balance and tyre management, but that's completely normal for this time of year. We're working through it together as a Team to get where we want to be for Australia. I've known the people here for a while now, but it's great to be working with them again in an environment like this." ASTON MARTIN The Aston Martin Aramco Formula One™ Team concluded its testing programme at the Bahrain International Circuit today, with Lance Stroll returning to the cockpit of the AMR26 for the final time before the Australian Grand Prix. Lance did not get on track until late in the morning session due to a battery-related issue that had impacted Fernando's running yesterday. Honda carried out simulations on the test bench at HRC Sakura before the car returned to the track. Due to a shortage of power unit parts, the run plan was very limited and consisted only of short stints. Lance Stroll “It's been a challenging couple of weeks here in Bahrain, and today's limited running wasn't the way we wanted to finish the second test. It's clear the car isn't where we want it to be performance-wise, and we know there's a lot of work ahead in the coming weeks and months. There's a long season ahead, and we'll keep pushing flat out to unlock more performance. I want to say a big thank you to everyone trackside and back at the AMRTC for the work that's gone in so far. It's not where we want to be right now, but I know how determined this team is. We'll stick together, rise to the challenge and keep working until we deliver the performance we are looking for.” WILLIAMS F1 2026 Bahrain pre-season testing – Day 3 James Vowles, Team Principal: Another solid day of running and mileage. It's great to see that across the last six days of testing, we've been predominantly tyre and time limited, and able to complete the full programme that we wanted. That's just a testament to the hard work of the teams, both here and in Grove, making sure that we made up for lost time. 
 No one truly knows where all the performance lies. That's what Melbourne is all about, so I can't wait to go there, to gain a further understanding of where we are. What I know for sure, though, is we have work to do. There's no doubt about it. We've put ourselves on the back foot. But my assurance to everyone is that we have an aggressive programme lining up in front of us in order to make sure that we extract as much performance in this car as possible over the forthcoming months. Carlos Sainz: The past six days of testing in Bahrain has been one of the most interesting and challenging tests that I've been part of, given the new regulations and number of things we had to learn. The progress from day one has been significant, although there are still going to be things to understand and solve at the start of the season. We go into the first half of the year with lower expectations than 2025 knowing that we'll be starting slightly on the back foot. However, I'm really looking forward to getting started and focusing on improving the cars through the year to become more competitive. Bring on Melbourne! Alex Albon: It's been a relatively smooth test here in Bahrain. We got some good mileage under our belts and tested everything we wanted to get out of the car, so I'm feeling more ready for Melbourne. There's still a lot we need to understand and plenty of performance left on the table that we need to extract, but I'm glad the tests went to plan. It's now all about maximising the next few days to prepare for the first race of the year! THIS WEEK'S INTERVIEW WITH MIKI MONRAS... Miki Monrás on battling Bottas and Ricciardo in the late 2000s and the rising cost of junior racing In the late 2000s, Miki Monrás was one of Spain's brightest prospects on the junior single-seater ladder, trading blows with the likes of Daniel Ricciardo, Valtteri Bottas and António Félix da Costa in Formula Renault and GP3. But while his rivals pushed on towards F1 or careers in GTs, the Spaniard's single-seater journey came to an abrupt halt in 2011. Feeder Series caught up with Monrás to reflect on the times he rubbed shoulders with greatness, the challenges of racing in the post–financial crisis era, and life beyond motorsport. By Anabelle Bremner Back in the noughties, the path from karting to Formula 1 looked nothing like it does today. There was no standardised Formula 4, no carefully managed ladder – just a patchwork of championships that rewarded those brave enough, and wealthy enough, to dive straight in. Eurocup Formula Renault 2.0 was as deep as it got: 40-car grids stacked with future stars, the proving ground where Pierre Gasly, Nyck de Vries and Lando Norris would come to cut their teeth. But before all of them, it was Monrás in the thick of it. He made his single-seater debut in late 2007, the result of years spent chasing speed. His first taste of racing, in fact, came on two wheels – on a motocross bike, inspired by his father, who had raced professionally in Spain and Europe. At the age of eight, Monrás joined a motocross camp, and it wasn't long before karting came calling. “After the first race, I really enjoyed it,” he recalls. “I remember it was Christmastime and I asked for a motocross scooter and for a go-kart. So I finally got the go-kart, and that's the way I started. Then I started racing in Catalonia, and I just moved through Spain and Europe and all the world championships until formula.” Single-seater racing, however, would prove a unique beast. Shortly before turning 16, Monrás moved straight from karting into Formula Renault 2.0, in which the competition was fierce. “Normally at that age you'd go before to a category not straight to 2.0,” he said. “My first year I was racing with Bottas, I was racing with Ricciardo, I was racing with [Andrea] Caldarelli – really good drivers.… I was racing against people that were already racing for two years in single-seaters. That was a big difference.”His first Eurocup campaign, in 2008, proved a challenging one. He was scoreless for his first five rounds with the Hitech Junior Team (no relation to the current Hitech) before a switch to SG Formula brought him six points in the final two rounds. Valtteri Bottas, then of Motopark Academy, went on to claim that year's title after a close fight involving Ricciardo, Caldarelli and Roberto Merhi. The next year brought Monrás a decidedly better season and three podiums with SG Formula, owned by Mercedes Junior Team advisor Stéphane Guerin. He wound up fifth overall in a season dominated by a fierce three-way fight between Félix da Costa, Jean-Éric Vergne and Albert Costa – the last of whom ultimately took the title. Racing against so much talent at such a young age left Monrás with plenty of perspective on what might have been. “Ricciardo was my teammate. Jean-Éric Vergne was my teammate. I raced with Da Costa, Bottas, with Magnussen, so many people that have been racing each other and winning races,” he said. “[I] think if I changed something at that point, maybe I would be in Formula 1, but who knows. Maybe yes, maybe no. “But at that time, it was really difficult times because it was 2010, '11, '12, where there was also a big crisis in the world, especially in Europe. It was really difficult for Spanish drivers to get the sponsors and the money to race.” The financial squeeze triggered by the 2008 global financial crisis left Monrás and many of his peers in a precarious position. Several teams, such as SG Formula, shut their doors in the wake of the crisis amidst an already shifting landscape in junior racing. “It's been changing a lot from that time until now. When I was racing Eurocup 2.0, one time we were like 48 drivers, I remember. 2008 at Spa. It was a massive level and so many drivers wanted to go in,” he said. “Eurocup was really high level, I would say maybe [comparable] to Formula 4 about the car and the lap times. “Motorsport has changed a lot in the last few years. It's more expensive. At that time, Eurocup was also expensive, but I think Formula 4 is around €700,000 more or less, maybe more now. It's quite expensive. Back then, I think Eurocup was around €300,000 or €250,000, so there was a massive difference. A lot more people could race at that time.” After two and a half years competing in various Formula Renault series, Monrás stepped up to GP3 in 2010. The inaugural season, won by eventual F1 driver Esteban Gutiérrez, came with another steep learning curve. Monrás managed two podiums and a 10th-place finish in the standings, but the step up exposed the limits of what talent alone could achieve in a field packed with hungry, well-backed drivers. “When I raced GP3, that was the first year of the championship, so it was a new championship for all of the teams. I also raced with Arden, which was a new team in the category, so it made it a bit difficult,” he said. “During testing, I remember I was flying in GP3, and then suddenly in some races there was such a huge difference with some other cars and drivers. It was difficult sometimes. … I think this is always present in motorsport in all categories. You will find some kind of differences within cars and teams. It just will always be there.” Challenging as it was, that season had its highs for Monrás. A recovery drive in Spa's characteristic rain remains a fond memory for the Spaniard. “I had a really bad qualifying because there were some yellow flags,” he explained. “Because there were 30 cars, it was easy to find yellow flags if you're waiting for the last minutes in qualifying. I finished [ninth in] race one, and in race two it started raining really heavily after five laps. I went from P10 to P3, nearly fighting for the win in the last lap against Rossi and Tambay. That was a really good race.” After a season in GP3, Monrás moved up a rung on the ladder to Formula Two. At the time, the feeder series landscape was fragmented. GP2 and Formula Renault 3.5 offered established paths to Formula 1, while the MotorSport Vision's FIA Formula Two Championship, which first ran in 2009, aimed to do the same with a more affordable package. “Formula Two at that point was very competitive, economically speaking,” Monrás said. “It was a lot cheaper to race in Formula Two than race in GP2 at that moment or 3.5 because it was like all one team. All the cars were one team with different engineers, and that made it low cost for the time. “A lot of drivers went to it because of that. They were racing in the best tracks, same as World Series and similar to GP2, and the car was competitive. Maybe not as competitive as GP2 or 3.5 because it was a bit slower, but it was really competitive and really fast, on the straight especially.”  “In that time, what they were saying was it was very equal. You had one engineer for three cars, you were sharing data with these three cars, and it was all under the same team. You can always find differences in motorsport. Maybe not a difference to make one car win and one car P15, but you can still always find two-tenths difference in similar cars, and two tenths, sometimes it's a lot of time,” he said. “The cars were on the same team, but each engineer was doing the set-up for his driver. The set-up I was using and maybe the set-up Bortolotti was using, he had won the championship maybe from our different set-ups. Every race, you changed engineers. Every weekend, you were rotating engineers so at the end of the season, everybody worked with everyone.” By 2012, the funding had dried up. Monrás was left sponsorless and unable to compete in Formula Two. He sampled GT racing in the Blancpain Endurance Series and tested with both Audi Sport and Atech GP, but no program materialised. From there, Monrás transitioned into driver coaching and team management – mostly with the AV Formula team owned by his manager, Adrian Vallés – and eventually “moved on” from motorsport around 2017. “I was working also with McLaren Automotive, but it was not motorsport. It was automotive, developing road cars, really competitive cars. After that I decided to stop because I wanted to follow a new career professionally, and I moved onto real estate which I have always been [involved with] because of my family, so that's why I decided to move over,” he said. “I now work in a real estate company which I own with some partners, and that's my day-to-day nowadays.” After years climbing the ladder in lockstep with some of the sport's future stars, Monrás has found a new rhythm – one that's decidedly less fast, but no less his own. Yet his career remains a reminder of the talent that defined an era: a Spaniard who went wheel to wheel with the likes of Ricciardo, Bottas, and Vergne, racing in some of the deepest junior grids of the 2000s and 2010s. In the story of that generation, Monrás may no longer be on track, but he's never far from the memory of it all.

MASTERMIND CRIMINAL
COMO REDIGIR UMA RECLAMAÇÃO CONSTITUCIONAL DE FORMA ESTRATÉGICA | RODRIGO BORTOLOTTI

MASTERMIND CRIMINAL

Play Episode Listen Later Dec 9, 2025 70:01


Conheça a maior comunidade de criminalistas do Brasil: https://app.nectarcrm.com.br/crm/api/1/webform/view/50OLeen5k9Iyy5PkpMXjBacPr6hst08ECA7IME4EI6Q?utm_source=Youtube&utm_medium=Comunidade&utm_contentSabe como usar a Reclamação Constitucional de forma estratégica?Neste episódio, o advogado Rodrigo Bortolotti revela os principais erros, acertos e estratégias que fazem a diferença na atuação nos Tribunais Superiores.Do pedido de liminar ao julgamento, passando pela construção do texto da peça, a conversa entrega conteúdo prático e visão de carreira.Um episódio imperdível para quem busca alta performance na advocacia!

Les Experts France Bleu Sud Lorraine
C'est un dispositif qui séduit de plus en plus de français : la retraite progressive à 60 ans, on en parle avec Audrey BORTOLOTTI de la CARSAT Nord est

Les Experts France Bleu Sud Lorraine

Play Episode Listen Later Oct 21, 2025 43:30


durée : 00:43:30 - Bienvenue chez vous : à la Une Vous aimez ce podcast ? Pour écouter tous les autres épisodes sans limite, rendez-vous sur Radio France.

ButterCup
Ep 72 Rosalba Bortolotti

ButterCup

Play Episode Listen Later Aug 21, 2025 51:21


Rosalba is a highly experienced pedagogist with over 29 years dedicated to early childhood education and pedagogical research. Holding a degree in Early Childhood Education with a specialization in Psychology, she began her career as an educator in 1994. Her deep interest led her to explore and research the innovative Reggio Emilia approach, including direct visits to its renowned schools. As the former owner of a private nursery school that also served as a learning lab, Rosalba pioneered a new approach to early learning in her community, advocating for the rights of both children and educators. She has shared her expertise as an Early Childhood Education professor at a college and has served as a pedagogical consultant for over two decades, guiding various educational institutions. In this capacity, she also develops comprehensive modules, offering educators structured series for deeper knowledge development and access to valuable resources. Rosalba embraces modern professional learning, developing online workshops, webinars, and contributing to podcasts for various agencies and organizations. These virtual spaces offer a wide community of educators, artists, chefs, families, and researchers opportunities for professional development and collaboration. She continues to present at workshops and conferences, both in person and virtually. Passionate about intentional material use, Rosalba advocates for thoughtful engagement with resources, drawing inspiration from the Reggio Emilia approach to foster deeper connections with the environment. She emphasizes shifting from a culture of consumption to one of creative resourcefulness, promoting resilience and sustainability in early learning. Viewing children as future citizens, Rosalba champions educational practices that empower them to explore and grow, fostering their development as responsible contributors to society. Her expertise also extends to food pedagogies, collaborating with chefs to develop workshops for educators, families, and children, and contributing a chapter to "Beautiful Stuff in Nature" on the journey of a tomato. Currently, Rosalba continues her work as a consultant, speaker, and pedagogical companion, actively writing blogs and contributing to the Pedagogist Network Ontario. She is also a certified Play Worker and volunteers as chair of the York Region Nature Collaborative, connecting educators with outdoor learning experiences. Her extensive background and innovative methods consistently contribute to the advancement of early childhood education. For updates and current events, visit www.acorncollaborative.com or connect on social media: @acorncollaborative (IG) and Rosalba Bortolotti (FB, LinkedIn).

Programa del Motor: AutoFM
Victoria histórica de Grasser Racing y Lamborghini en las 24h de Spa 2025 | AutoFM - Motorsport

Programa del Motor: AutoFM

Play Episode Listen Later Jul 5, 2025 11:10


️ Extracto de nuestro programa en directo sobre las 24h de Spa Victoria histórica para Lamborghini y Grasser Racing en las 24 Horas de Spa. Bortolotti, Pepper y Engstler lograron el primer triunfo para la marca italiana en esta emblemática carrera, tras una lucha feroz contra el Porsche de Rutronik Racing, que terminó segundo. Lamborghini conquista Spa por primera vez en su historia ⏱️ Final de infarto: menos de un segundo entre primero y segundo en la última hora Ferrari AF Corse remonta desde el puesto 65 y cierra podio Verstappen.com Racing gana la Gold Cup tras dura batalla con Garage 59 Walkenhorst Motorsport domina en Silver Cup con Aston Martin Kessel Racing se lleva la Bronze Cup y AV Racing gana Pro-Am 128,000 espectadores disfrutaron del espectáculo en los Ardennes Toda la emoción y análisis de esta edición única, con estrategia, velocidad y momentos emocionantes de principio a fin. Sigue nuestro programa en Twitch y YouTube cada miércoles a las 22:00. Escúchanos en: www.podcastmotor.es Twitter: @AutoFmRadio Instagram: autofmradio Twitch: AutoFMPodcast Contacto: info@autofm.es

Track Limit by Endurance-Info
Track Limit - Bilan et analyse des 24 Heures de Spa 2025

Track Limit by Endurance-Info

Play Episode Listen Later Jul 3, 2025 59:49


Après dix ans de tentatives infructueuses, Lamborghini a enfin remporté les 24 Heures de Spa le week-end dernier en Belgique grâce à son plus ancien et fidèle partenaire dans l'aventure Huracan GT3 : le Grasser Racing Team avec la n°63 de Mirko Bortolotti - Luca Engstler - Jordan Pepper. Endurance-Info revient sur ce succès et sur les points à retenir de cette semaine spadoise dans le nouveau numéro de son podcast Track Limit, à écouter ci-dessous.Hébergé par Ausha. Visitez ausha.co/politique-de-confidentialite pour plus d'informations.

Motorsport – meinsportpodcast.de
Boxenfunk - Der Motorsport-Podcast Folge 87

Motorsport – meinsportpodcast.de

Play Episode Listen Later Jun 4, 2025 11:29


Mirko Bortolotti In dieser Folge blicken wir mit Mirko Bortolotti voraus auf das DTM-Rennwochenende in Zandvoort. Der aktuelle Champion verrät was die Faszination DTM für ihn ausmacht und warum ihn die Serie nicht mehr loslässt. Dabei wird es auch persönlich: Bortolotti spricht über seine Werte, seine Haltung im Sport und die besondere Verbindung zu den Fans, die ihn auf jedem Meter begleiten. Ein echter Einblick hinter das Visier! Hier geht es zur DTM: https://dtm.com/de Hier findest Du DIE AUTOSEITEN: https://www.dieautoseiten.de/ Wünsche, Anregungen, Lob oder Kritik? Scheib uns: boxenfunk [at] gmail [punkt] com ...Dieser Podcast wird vermarktet von der Podcastbude.www.podcastbu.de - Full-Service-Podcast-Agentur - Konzeption, Produktion, Vermarktung, Distribution und Hosting.Du möchtest deinen Podcast auch kostenlos hosten und damit Geld verdienen?Dann schaue auf www.kostenlos-hosten.de und informiere dich.Dort erhältst du alle Informationen zu unseren kostenlosen Podcast-Hosting-Angeboten. kostenlos-hosten.de ist ein Produkt der Podcastbude.Führung beginnt mit Gefühl: Im Podcast Führungsgefühle erfährst du, wie emotionale Intelligenz, Selbstreflexion und neue Leadership-Ansätze echte Veränderung bewirken können. Jetzt entdecken auf www.fuehrungsgefuehle.de.

Boxenfunk
Boxenfunk - Der Motorsport-Podcast Folge 87

Boxenfunk

Play Episode Listen Later Jun 4, 2025 11:29


In dieser Folge blicken wir mit Mirko Bortolotti voraus auf das DTM-Rennwochenende in Zandvoort. Der aktuelle Champion verrät was die Faszination DTM für ihn ausmacht und warum ihn die Serie nicht mehr loslässt. Dabei wird es auch persönlich: Bortolotti spricht über seine Werte, seine Haltung im Sport – und die besondere Verbindung zu den Fans, die ihn auf jedem Meter begleiten. Ein echter Einblick hinter das Visier!

Les Experts France Bleu Sud Lorraine
Emission spéciale retraite, posez vos questions à Audrey Bortolotti, de la CARSAT Nord Est

Les Experts France Bleu Sud Lorraine

Play Episode Listen Later May 27, 2025 43:42


durée : 00:43:42 - Emission spéciale retraite, posez vos questions à Frédérique Henry de la CARSAT Nord Est

Awakened to Reggio
An Amiable Space with Rosalba Bortolotti

Awakened to Reggio

Play Episode Listen Later Feb 5, 2025 36:22


Rosalba Bortolotti is a highly experienced and dedicated pedagogist, presenter, pedagogical consultant, author, and the Founder & Executive Director at Acorn Collaborative in Ontario, Canada.

United Citizens of Europe Podcast
Smart Cities in Europe with Alberto Bortolotti | United Citizens of Europe

United Citizens of Europe Podcast

Play Episode Listen Later Jan 25, 2025 40:14


In this episode of the United Citizens of Europe podcast, we explore the exciting world of Smart Cities with Alberto Bortolotti, a renowned architect and urbanist. We explore the crucial role of citizen involvement in shaping the future of our cities, discussing how technology can be harnessed to improve urban living while prioritizing human needs and social equity. We also discussed the "Milan Model" and discussed whether Milan truly exemplifies a Smart City. Alberto shares valuable insights on the importance of inclusive and participatory planning processes, emphasizing the need to empower citizens to actively shape the development of their own communities.  Host of the episode: ⁠Luca P. De Cristofaro Guest: Alberto Bortolotti Follow United Citizens of Europe: IG: ⁠@unitedcitizensofeurope⁠ Facebook: ⁠United Citizens of Europe⁠ ⁠www.unitedcitizensofeurope.com

Les Experts France Bleu Sud Lorraine
Vous avez pris votre retraite avant l'heure (retraite anticipée pour carrière longue, handicap, convenance personnelle) racontez-nous ? Avec Audrey Bortolotti de la CARSAT Nord Est

Les Experts France Bleu Sud Lorraine

Play Episode Listen Later Sep 24, 2024 53:28


durée : 00:53:28 - Vous avez pris votre retraite avant l'heure (retraite anticipée pour carrière longue, handicap, convenance personnelle) racontez-nous ? Avec Audrey Bortolotti de la CARSAT Nord Est

il posto delle parole
Nicoletta Bortolotti "I bambini di Gaza"

il posto delle parole

Play Episode Listen Later May 11, 2024 12:01


Nicoletta Bortolotti"I bambini di Gaza"Mondadori Editorewww.mondadori.itEstate 2003. Mahmud e Samir vivono a Gaza City, una città colpita ogni giorno dai bombardamenti. Non potrebbero essere più diversi, ma hanno una grande passione in comune: il surf. Appena possono, corrono al mare ad aspettare un'onda da cavalcare, quell'attimo sospeso in cui sentirsi liberi, l'unico modo per scappare, anche solo per un momento, dalle difficoltà della guerra. I due ragazzi si incontrano spesso sulla spiaggia, ma si guardano a distanza con curiosità mista a sospetto: uno è palestinese, l'altro israeliano, e le loro famiglie non vogliono neanche che si rivolgano la parola. Ma l'incontro con Bill, un maestro di surf, cambierà ogni cosa. Perché nel surf, come nell'amicizia, non esistono barriere...Un racconto di libertà e coraggio, ispirato a fatti realmente accaduti, già conosciuto come Sulle onde della libertà.Una storia di amicizia a Gaza City, torna in libreria in una nuova veste cinematografica.Titolo originale: RollRegia: Loris LaiCast: Lyna Khoudri, Marwin Hemdan, Mikael Fridel, Ruth Rosenfeld, Tom Rhys HarriesDurata: 01:52Anno: 2024Nicoletta BortolottiÈ un'affermata autrice italo-svizzera. Vive a Milano dove lavora in ambito editoriale. Ha pubblicato libri per adulti e ragazzi con le più importanti case editrici italiane; per Mondadori ha scritto Quelle in cielo non erano stelle (2021), finalista al premio Bancarellino, e ha collaborato a Un sogno al microscopio (con Piera Levi-Montalcini e Alberto Cappio, 2022), dedicato alla storia di Rita Levi-Montalcini. Nel 2023 è stata candidata al Premio Strega con Un giorno e una donna (HarperCollins, 2022).IL POSTO DELLE PAROLEascoltare fa pensarewww.ilpostodelleparole.itDiventa un supporter di questo podcast: https://www.spreaker.com/podcast/il-posto-delle-parole--1487855/support.

Biz'Care podcast, par Bilkher DIAKHATE
Atteindre 1000 visiteurs par jour sur WP en 6 mois, avec Alex Bortolotti

Biz'Care podcast, par Bilkher DIAKHATE

Play Episode Listen Later May 8, 2024 70:48


D'un projet étudiant, son site atteint les 90.000 visiteurs mensuels, WP Marmite est devenu la référence WordPress francophoneDans l'épisode du jour, Alex revient sur la success story du site de référence qu'on ne présente plus,Et surtout, Alex va vous dire exactement- Quels plugins choisir- Quelles structures de pages WordPress mettre en place- Quels sont les prérequis à prendre en compte lorsqu'on choisit un thème WPLe tout en mode 20% d'outils pour 80% de résultats.Alex te donne avec humilité le parfait playbook du site WordPress optimisé pour le SEO en 2024 dans cet épisode.Un épisode full valeur avec une personne de valeur. Un like + commentaire pour soutenir ce podcast et le faire connaître au maximum ❤️Hébergé par Ausha. Visitez ausha.co/politique-de-confidentialite pour plus d'informations.

Alice
Joël Dicker, Nicoletta Bortolotti e Olimpia De Girolamo

Alice

Play Episode Listen Later Apr 27, 2024 73:25


Autori svizzeri per nascita o adozione, oggi ad Alice, e libri che coprono un ampio spettro di generi letterari. C'è il romanzo storico di Nicoletta Bortolotti, che è di Sorengo ma da molti anni vive in Italia; c'è la fiction drammatica di Olimpia De Girolamo, che è nata a Napoli e vive in Ticino. E poi, da Ginevra, c'è il thriller di Joël Dicker, 13 milioni di copie vendute in tutto il mondo (beninteso, prima della pubblicazione dell'ultimo romanzo Un animale selvaggio). Quella di Joël Dicker sarà la prima voce che ascolteremo in questa puntata con Alice, per raccontare Un animale selvaggio di cui è uscita da qualche settimana la traduzione in italiano per La nave di Teseo. Parleremo poi con Nicoletta Bortolotti, professionista dell'editoria e scrittrice, che proprio quest'anno ha visto il suo I bambini di Gaza – Le onde della libertà diventare un film. Il suo ultimo libro Un giorno e una donna è un romanzo storico che gira intorno alla prima scrittrice protofemminista della storia: Christine de Pizan.Infine sarà con noi Olimpia De Girolamo, che torna nelle librerie con Volontà pubblicato da Gabriele Capelli editore. Come in Tutto ciò che siamo stati, suo romanzo d'esordio, una scomparsa diventa il tragico motore della vicenda, costruita con un alternarsi di terza e prima persona.

How to Choose
8 Attributes of Good Decision Makers - Realistic Optimism

How to Choose

Play Episode Listen Later Jan 9, 2024 17:33


In episode 3 of season 5, we discuss the attribute of realistic optimism and how it helps us be better decision-makers. SUMMARYRealistic optimism accepts the reality - both good and bad - of every situation, but applies a positive attitude to make the best of the situation and pursue our goals with energyPessimism isn't the same as realism. Pessimism focuses on unlikely negative outcomes and ignores the statistical likelihood that something bad will happen. Being sceptical means not accepting things on face value - it is a questioning, curious mindset that serves us better than pessimismWe can build realistic optimism by applying the ABC framework to analyse how we respond to adversity, adjusting our beliefs to support a more constructive decision that produces better consequences that help us achieve our goalsRESOURCESCurious to learn more about realistic optimism? Here's the details of some interesting articles:https://www.forbes.com/sites/forbescoachescouncil/2021/01/07/how-to-incorporate-realistic-optimism-into-your-life/?sh=24d6696876f0 Carver, Charles S., Michael F. Scheier, and Suzanne C. Segerstrom. “Optimism.” Clinical Psychology Review 30, no. 7 (2010): 879–89. https://doi.org/10.1016/j.cpr.2010.01.006.Jefferson, Bortolotti & Kuzmanovic, ‘What is Unrealistic Optimism?', Consciousness & Cognition, 50 (2017)Martin Seligman, ‘Learned Optimism: How to Change Your Mind and Your Life' (Vintage Books; New York, 1990)Are you, or someone you know, negatively impacted by gambling? Here's a couple of links that might help:https://www.gamblinghelponline.org.au/https://www.helpguide.org/articles/addictions/gambling-addiction-and-problem-gambling.htm IN OUR NEXT EPISODE...In episode 4 of this season, we'll be discussing the benefits of being 'knowledge-hungry'. Don't miss it!

Unlocked by Matt Landau
Leading With Love with Antonio Bortolotti

Unlocked by Matt Landau

Play Episode Listen Later Nov 23, 2023 34:30


Today's episode features Antonio Bortolotti, who runs the vacation Rental World Summit with his wife, Christina. It's become the preeminent event in Europe and the Middle East for vacation rental professionals. In this episode, Antonio and I recount this most extraordinary moment on stage at the end of the Vacation Rental World Summit in Barcelona just a couple weeks ago. We go through some of the sequences that neither of us could have fathomed, along with the consequences of what happened on stage and these shifts in priorities that myself and Antonio and I'm guessing a lot of you are going through in life as we evolve. This episode is brought to you by Breezeway, https://www.breezeway.io/vrmb the best-in-class property care and operations platform, and bnbfinder, https://www.bnbfinder.com/list, a book direct marketplace with a 20-year history connecting travelers with unique places to stay. No commissions, no processing fees, no service fees. Plain and simple.

Giallo Quotidiano
Monia Bortolotti - "E' pericolosa"

Giallo Quotidiano

Play Episode Listen Later Nov 17, 2023 8:16


Una giovane madre della provincia di Bergamo è stata arrestata.Seguimi su YouTube: https://www.youtube.com/channel/UClkB_8jqDS7SWoltMjIu-3Q/Supporta il progetto qui: https://www.paypal.com/paypalme/pierjcSupport this podcast at — https://redcircle.com/storia/donationsAdvertising Inquiries: https://redcircle.com/brandsPrivacy & Opt-Out: https://redcircle.com/privacy

GT-Talk der GT und Langstrecken Podcast
Der neue Champ aus Österreich - Rückblick und News

GT-Talk der GT und Langstrecken Podcast

Play Episode Listen Later Oct 26, 2023 29:46


In dieser  Ausgabe schauen wir auf das perfekte Finalwochenende der DTM-Saison 2023, bei dem der Champion Thomas Preining im Manthey-EMA-Porsche triumphierte. Nachdem Preining mit seinen drei Punkten im Sonntags-Qualifying den Titel gesichert hatte, bewies er seine Dominanz in Hockenheim, indem er sowohl die Pole-Positionen als auch beide Siege sicherte. Doch sein hartnäckiger Titelrivalen Mirko Bortolotti im SSR-Lamborghini gab nicht auf und machte ihm das Leben schwer. In einem packenden Rennen behielt Preining die Oberhand, während Bortolotti hartnäckig den zweiten Platz gegen starke Konkurrenz verteidigte. Das Rennen versprach von Anfang bis Ende Hochspannung und wurde in der dritten Runde durch eine Safety-Car-Phase unterbrochen, nachdem ...Du möchtest deinen Podcast auch kostenlos hosten und damit Geld verdienen? Dann schaue auf www.kostenlos-hosten.de und informiere dich. Dort erhältst du alle Informationen zu unseren kostenlosen Podcast-Hosting-Angeboten. kostenlos-hosten.de ist ein Produkt der Podcastbude.Gern unterstützen wir dich bei deiner Podcast-Produktion.

Motorsport – meinsportpodcast.de
Der neue Champ aus Österreich - Rückblick und News

Motorsport – meinsportpodcast.de

Play Episode Listen Later Oct 26, 2023 29:46


In dieser  Ausgabe schauen wir auf das perfekte Finalwochenende der DTM-Saison 2023, bei dem der Champion Thomas Preining im Manthey-EMA-Porsche triumphierte. Nachdem Preining mit seinen drei Punkten im Sonntags-Qualifying den Titel gesichert hatte, bewies er seine Dominanz in Hockenheim, indem er sowohl die Pole-Positionen als auch beide Siege sicherte. Doch sein hartnäckiger Titelrivalen Mirko Bortolotti im SSR-Lamborghini gab nicht auf und machte ihm das Leben schwer. In einem packenden Rennen behielt Preining die Oberhand, während Bortolotti hartnäckig den zweiten Platz gegen starke Konkurrenz verteidigte. Das Rennen versprach von Anfang bis Ende Hochspannung und wurde in der dritten Runde durch eine Safety-Car-Phase unterbrochen, nachdem ...Du möchtest deinen Podcast auch kostenlos hosten und damit Geld verdienen? Dann schaue auf www.kostenlos-hosten.de und informiere dich. Dort erhältst du alle Informationen zu unseren kostenlosen Podcast-Hosting-Angeboten. kostenlos-hosten.de ist ein Produkt der Podcastbude.Gern unterstützen wir dich bei deiner Podcast-Produktion.

The Marshall Pruett Podcast
MP 1446: The Week In Sports Cars with Pfaff's Steve Bortolotti, Oct 9 2023

The Marshall Pruett Podcast

Play Episode Listen Later Oct 9, 2023 15:44


It's The Week In Sports Cars show featuring Marshall Pruett and Pfaff Motorsports' boss Steve Bortolotti who explores the team's switch from Porsche to McLaren in IMSA'a GTD Pro class starting in 2024. If you'd like to join the PrueDay podcast listener group, send an email to pruedayrocks@gmail.com and you'll be invited to participate in the Discord chat that takes place every day and meet up with your new family at events. Every episode of The Week In Sports Cars is brought to us by Cooper Tires, the Justice Brothers, and TorontoMotorsports.com. Play on Podbean.com: https://marshallpruett.podbean.com/ Subscribe: https://marshallpruettpodcast.com/subscribe Join our Facebook Group: https://www.facebook.com/MarshallPruettPodcast [WSC]

discord porsche podbean mclaren sports cars imsa pfaff bortolotti cooper tires marshall pruett
Motorsport – meinsportpodcast.de
Emotionale Siege und Titelkampf auf dem Red Bull Ring - Analyse und Vorschau

Motorsport – meinsportpodcast.de

Play Episode Listen Later Sep 27, 2023 50:25


Kelvin van der Linde gewinnt das Samstagsrennen der DTM am Red-Bull-Ring in Spielberg, sein erster Sieg seit 2021. Das Rennen erstreckte sich über 37 Runden bei wechselnden Bedingungen. Teamkollege Ricardo Feller beeindruckt mit einer Aufholjagd von Platz 26 auf den dritten Platz. Maro Engel belegt den fünften Platz, während Mirko Bortolotti seine Gesamtführung trotz eines neunten Platzes behält. Am Sonntag gewinnen Rene Rast und Sheldon van der Linde (Schubert) das Rennen, wobei Thomas Preining (Manthey-EMA-Porsche) die Tabellenführung übernimmt. Mirko Bortolotti erlebt ein Rennen zum Vergessen mit einem Reifenschaden und einem weiteren Problem im Cockpit. Rast feiert seinen ersten Sieg als BMW-Pilot, während ...Du möchtest deinen Podcast auch kostenlos hosten und damit Geld verdienen? Dann schaue auf www.kostenlos-hosten.de und informiere dich. Dort erhältst du alle Informationen zu unseren kostenlosen Podcast-Hosting-Angeboten. kostenlos-hosten.de ist ein Produkt der Podcastbude.Gern unterstützen wir dich bei deiner Podcast-Produktion.

GT-Talk der GT und Langstrecken Podcast
Emotionale Siege und Titelkampf auf dem Red Bull Ring - Analyse und Vorschau

GT-Talk der GT und Langstrecken Podcast

Play Episode Listen Later Sep 27, 2023 50:25


Kelvin van der Linde gewinnt das Samstagsrennen der DTM am Red-Bull-Ring in Spielberg, sein erster Sieg seit 2021. Das Rennen erstreckte sich über 37 Runden bei wechselnden Bedingungen. Teamkollege Ricardo Feller beeindruckt mit einer Aufholjagd von Platz 26 auf den dritten Platz. Maro Engel belegt den fünften Platz, während Mirko Bortolotti seine Gesamtführung trotz eines neunten Platzes behält. Am Sonntag gewinnen Rene Rast und Sheldon van der Linde (Schubert) das Rennen, wobei Thomas Preining (Manthey-EMA-Porsche) die Tabellenführung übernimmt. Mirko Bortolotti erlebt ein Rennen zum Vergessen mit einem Reifenschaden und einem weiteren Problem im Cockpit. Rast feiert seinen ersten Sieg als BMW-Pilot, während ...Du möchtest deinen Podcast auch kostenlos hosten und damit Geld verdienen? Dann schaue auf www.kostenlos-hosten.de und informiere dich. Dort erhältst du alle Informationen zu unseren kostenlosen Podcast-Hosting-Angeboten. kostenlos-hosten.de ist ein Produkt der Podcastbude.Gern unterstützen wir dich bei deiner Podcast-Produktion.

GT-Talk der GT und Langstrecken Podcast
Bortolotti Masterclass in der Hitze vom Lausitzring - Analyse DTM

GT-Talk der GT und Langstrecken Podcast

Play Episode Listen Later Aug 23, 2023 46:28


Mirko Bortolotti beschrieb seinen Kampf um den Sieg gegen Ricardo Feller im DTM-Rennen am Sonntag auf dem Lausitzring als "wirklich hart und fair". Er sagte, dass der "kleinste Fehler" es dem Audi-Fahrer ermöglicht hätte, den Sieg zu erlangen. Bortolotti holte am Sonntag in dem 60-minütigen Rennen auf der deutschen Strecke seinen zweiten Sieg des Jahres und wurde damit der erste wiederholte Sieger der Saison. Gleichzeitig übernahm er die Führung in der Meisterschaft von Manthey EMA-Fahrer Thomas Preining. Der Sieg folgte einem hart umkämpften Rennen, in dem Fellers ABT Sportsline Audi R8 LMS GT3 Evo II den SSR Performance Lamborghini Huracan GT3 EVO2 konstant ...Du möchtest deinen Podcast auch kostenlos hosten und damit Geld verdienen? Dann schaue auf www.kostenlos-hosten.de und informiere dich. Dort erhältst du alle Informationen zu unseren kostenlosen Podcast-Hosting-Angeboten. kostenlos-hosten.de ist ein Produkt der Podcastbude.Gern unterstützen wir dich bei deiner Podcast-Produktion.

Motorsport – meinsportpodcast.de
Bortolotti Masterclass in der Hitze vom Lausitzring - Analyse DTM

Motorsport – meinsportpodcast.de

Play Episode Listen Later Aug 23, 2023 46:28


Mirko Bortolotti beschrieb seinen Kampf um den Sieg gegen Ricardo Feller im DTM-Rennen am Sonntag auf dem Lausitzring als "wirklich hart und fair". Er sagte, dass der "kleinste Fehler" es dem Audi-Fahrer ermöglicht hätte, den Sieg zu erlangen. Bortolotti holte am Sonntag in dem 60-minütigen Rennen auf der deutschen Strecke seinen zweiten Sieg des Jahres und wurde damit der erste wiederholte Sieger der Saison. Gleichzeitig übernahm er die Führung in der Meisterschaft von Manthey EMA-Fahrer Thomas Preining. Der Sieg folgte einem hart umkämpften Rennen, in dem Fellers ABT Sportsline Audi R8 LMS GT3 Evo II den SSR Performance Lamborghini Huracan GT3 EVO2 konstant ...Du möchtest deinen Podcast auch kostenlos hosten und damit Geld verdienen? Dann schaue auf www.kostenlos-hosten.de und informiere dich. Dort erhältst du alle Informationen zu unseren kostenlosen Podcast-Hosting-Angeboten. kostenlos-hosten.de ist ein Produkt der Podcastbude.Gern unterstützen wir dich bei deiner Podcast-Produktion.

Stay Nerd - Gaming Wildlife

Una delle prerogative per parlare di videogiochi in modi diversi da quelli mainstream è l'appropriazione di nuovi spazi di aggregazione e l'unico modo per farlo è insieme, con ogni contributo possibile. In quanto "radici di edera che crescono nelle crepe del capitalismo" (cit.), abbiamo deciso di dare spazio a Zona Warpa, la festa del videogioco ribelle e itinerante. Un progetto orizzontale nato da diversi cervelli, tra cui quello di Fabio "Kenobit" Bortolotti che è venuto nel nostro spazio per parlare dell'iniziativa e offrire numerosi spunti di riflessione sul modo in cui si parla di videogiochi e sul trasformare le difficoltà di tuttə in nuove opportunità. Con Luca Parri, Francesco Paternesi e Lorena Rao. Ospite: Fabio "Kenobit" Bortolotti

fabio zona bortolotti kenobit
Cars Yeah with Mark Greene
2300: Steve Bortolotti

Cars Yeah with Mark Greene

Play Episode Listen Later Apr 13, 2023 34:53


Steve Bortolotti is the General Manager at Pfaff Motorsports, one of the most successful sports car racing programs in North America. The team's long history includes Championships in the Porsche GT3 Cup Challenge, the Pirelli World Challenge, and the IMSA WeatherTech SportsCar Championship. This year's drivers include Klause Bachler, Laurens Vanthroor, and Patrick Pilet. Long time listeners will remember Laurance Yap, Pfaff's Marketing Director, is a past guest on Cars Yeah.  

north america general managers championships marketing directors pfaff bortolotti imsa weathertech sportscar championship cars yeah pirelli world challenge
She Builds Podcast
Episode 74: Maria Bortolotti Casoni

She Builds Podcast

Play Episode Listen Later Apr 4, 2023 44:58


Learn about the life, work, struggles, and achievements of Maria Bortolotti Casoni. For show notes and more information check out our website https://www.shebuildspodcast.com/episodes/mariabortolotticasoni

bortolotti
Le RPod
Le RPOD - Edito du 2/02/2023 - WEC : Kvyat et Bortolotti rejoignent Prema en LMP2 !

Le RPod

Play Episode Listen Later Feb 3, 2023 3:20


2/02/2023 - Le RPOD - Au sommaire de cet édito du 2 Fevrier : WEC : Kvyat et Bortolotti rejoignent Prema en LMP2 !

prema edito lmp2 kvyat bortolotti rpod
Hygiene2Vie - Une hygiène de vie plus équilibrée & plus sereine
140 - [ÉCLOSION] Céline BORTOLOTTI : BURN OUT "DE LA VIE" - Quand la wonderwoman se brûle les ailes

Hygiene2Vie - Une hygiène de vie plus équilibrée & plus sereine

Play Episode Listen Later Jan 18, 2023 50:36


Une femme pleine d'entrain et de motivation, une femme salariée qui décide de jouer à la wonderwoman pour changer de vie professionnelle mais aussi de vie personnelle.  Changement de carrière, formation pour devenir naturopathe et enseignante de yoga. Quitter sa région natale pour un endroit où elle n'a aucun repère...  Après 9 années dans un travail qui ne lui procurait aucun sens, elle décide de tout bouleverser sans y aller de main morte comme on dit ! Mais à la clé... elle s'est brûlée les ailes.  Au programme de cet épisode :  Je t'invite à rejoindre ma conversation avec Céline qui nous explique son parcours de reconversion, son burn out de la vie mais aussi et surtout toutes ses clés pour t'éviter à toi aussi peut-être cet épuisement profond.  Belle écoute♥︎ ------------------------------- Pour me contacter : https://hygiene2vie.fr/contactez-votre-coach-naturopathe-hygiene-2-vie/   Recevoir la Lettre mensuelle d'Hygiene2Vie : https://hygiene2vie.fr/lettrehygiene2vie/  Pour me soutenir : https://fr.tipeee.com/hygiene2vie

Continuous Delivery
L'elefante nella stanza: Mastodon - S03E05 - con Fabio “Kenobit” Bortolotti, Carlo Gubitosa e Collettivo Bida

Continuous Delivery

Play Episode Listen Later Dec 21, 2022 66:48


Con la reattività di un elefante che reagisce a una mosca che si posa sulla schiena, siamo qui a parlare finalmente di quello che da mesi è diventato un trending topic, dopo essere stato per molto più tempo un software underground conosciuto da pochi e usato da ancora meno: Mastodon! In questo episodio parliamo quindi di fediverso, e lo facciamo non con gente a caso, ma con i mantainer di alcune delle principali istanze Mastodon italiane.Con: Edoardo Dusi, Paolo Mainardi, Fabio “Kenobit” Bortolotti, Carlo Gubitosa e Collettivo Bida/* Link */https://mastodon.bida.im/abouthttps://livellosegreto.it/abouthttps://sociale.network/abouthttps://joinmastodon.org/https://pleroma.social/https://join.misskey.page//* Newsletter & Telegram */https://landing.sparkfabrik.com/continuous-delivery-newsletterhttps://t.me/continuous_delivery

il posto delle parole
Nicoletta Bortolotti "Un giorno una donna"

il posto delle parole

Play Episode Listen Later Nov 4, 2022 19:29


Nicoletta Bortolotti"Un giorno una donna"Harper Collinshttps://www.harpercollins.it/Ha detto che uomini e donne sono uguali e che “una donna intelligente riesce a far di tutto e anzi gli uomini sarebbero molto irritati se una donna ne sapesse più di loro”. Ha detto che bisogna fare studiare le bambine e se solo le donne avessero fatto i libri... Ha detto che le donne non provano piacere a essere stuprate, come molti credono, ma subiscono un dolore senza pari. Lo ha detto un giorno in cui Parigi era un tempo più che un luogo, e l'anno 1405 era un luogo più che un tempo. Lo ha detto nel Medioevo insanguinato dalla Guerra dei cent'anni tra Francia e Inghilterra.Davanti a tutta la corte francese, a re e nobili. Christine de Pizan, nata in Italia, prima storica donna, prima editor, poetessa e scrittrice. Donna. Nicoletta Bortolotti ricostruisce la sua vita, che, dopo un'infanzia meravigliosa al seguito del padre divenuto astronomo reale a Parigi, fu colpita da lutti e rovesci che la lasciarono, giovanissima, vedova e madre. Il risultato è un libro meraviglioso che da un lato sembra provenire dal passato, a partire dalla forma epistolare scelta, che tanti capolavori ha regalato alla letteratura, e che qui si incarna nelle lettere tra una madre e una figlia. E dall'altro è assolutamente moderno. Perché molte delle conquiste sognate da Christine si sono verificate solo in anni recenti, e altre si stanno verificando adesso, o devono ancora farlo.Con Un giorno e una donna Nicoletta Bortolotti ha scritto un romanzo importante, che è al tempo stesso un'opera di grande valore letterario in grado di far rivivere le passioni e i sentimenti di un'epoca, un'opera di grande valore storico nella ricostruzione perfetta, per quanto immersa nell'immaginazione romanzesca, della vita e dell'opera di Christine de Pizan, e di valore etico, perché l'esempio di Christine possa servire da guida in questi anni non sempre facili.IL POSTO DELLE PAROLEAscoltare fa Pensarehttps://ilpostodelleparole.it/

Rain City Supercars
Going to Plaid with Steve Bortolotti

Rain City Supercars

Play Episode Listen Later Oct 31, 2022 47:38


This week on the show we welcome Steve Bortolotti, General Manager of the IMSA winning team Pfaff Motorsports! You probably know the Pfaff livery even if you don't follow IMSA racing since they have the best looking Porsche on the track in it's clearly Canadian plaid wrap. Steve tells us all about the high and lows of racing, modding his Time Attack RX8, and a whole lot more. We can't wait to see what Pfaff does in 2023 in the new 992!

Web3 in Travel
Web3 in Travel Summit presentation with Antonio Bortolotti

Web3 in Travel

Play Episode Listen Later Sep 7, 2022 36:55


In this episode, Luca presents the first travel summit dedicated to the transition to Web3 together with Antonio Bortolotti, founder of the VRWS. Speeches, panels and workshops to help the industry upgrade to the new Web. The Web3 in Travel Summit is in Porto, Portugal on the 14th of September 2022. https://web3intravel.com https://vacationrentalworldsummit.com

GT-Talk der GT und Langstrecken Podcast
Lebe deinen Traum - Analyse und Vorschau

GT-Talk der GT und Langstrecken Podcast

Play Episode Listen Later Aug 31, 2022 70:28


Die van der Linde Brüder schreiben DTM-Geschichte auf dem Nürburgring. Als erstes Brüderpaar sicherten sich Sheldon und Kelvin van der Linde jeweils einen Platz auf dem Podium. Zwar verzögerte sich das Rennen am Samstag aufgrund des Nebels um fast 5 Stunden, doch das Rennen war dadurch um so dramatischer. Der Kontakt zwischen Fraga und Bortolotti war neben dem Doppelsieg der van der Linde Brüder das Thema am Samstag. Der Lamborghini Pilot entschuldigte sich direkt via Interview und auch beim Brasilianer, doch Frag äußerte berechtigterweise Unverständnis für diese unrühmliche Aktion. Am Sonntag ging es für den GRT-Grasser Piloten zwar nach der 5 Platz Gridstrafe nach vorne, doch beim Kampf um P4 mit Kelvin van der Linde ...Du möchtest deinen Podcast auch kostenlos hosten und damit Geld verdienen? Dann schaue auf www.kostenlos-hosten.de und informiere dich. Dort erhältst du alle Informationen zu unseren kostenlosen Podcast-Hosting-Angeboten. kostenlos-hosten.de ist ein Produkt der Podcastbude.Gern unterstützen wir dich bei deiner Podcast-Produktion.

Motorsport – meinsportpodcast.de
Lebe deinen Traum – Analyse und Vorschau

Motorsport – meinsportpodcast.de

Play Episode Listen Later Aug 31, 2022 70:28


Die van der Linde Brüder schreiben DTM-Geschichte auf dem Nürburgring. Als erstes Brüderpaar sicherten sich Sheldon und Kelvin van der Linde jeweils einen Platz auf dem Podium. Zwar verzögerte sich das Rennen am Samstag aufgrund des Nebels um fast 5 Stunden, doch das Rennen war dadurch um so dramatischer. Der Kontakt zwischen Fraga und Bortolotti war neben dem Doppelsieg der van der Linde Brüder das Thema am Samstag. Der Lamborghini Pilot entschuldigte sich direkt via Interview und auch beim Brasilianer, doch Frag äußerte berechtigterweise Unverständnis für diese unrühmliche Aktion. Am Sonntag ging es für den GRT-Grasser Piloten zwar nach der 5 Platz Gridstrafe nach vorne, doch beim Kampf um P4 mit Kelvin van der Linde krachte es schon wieder und er lässt damit auch am Sonntag wichtige Punkte liegen. Kritik gab es am Sonntag von René Rast und Co. beim Thema Strafe. Die Rennleitung rund um Scot Elkins wird aufgrund von zu wenigen harten Strafen kritisiert. Auch fehle es am Respekt zwischen den Fahrern, die wohl kaum mehr vorhanden ist. Alles Weitere zur DTM gibt es im ersten Teil der Episode. Im zweiten Teil haben wir die IMSA und den Porsche Mobil 1 Supercup für euch im Programm und dort blicken wir auf das Wochenende der beiden Meisterschaften zurück. Auch gibt es eine Vorschau auf das kommende GTWCE Endurance Rennen auf dem Hockenheimring an diesem Wochenende. +++ Hinweis +++ Wir unterstützen die Spendenaktionen für Flüchtende des Kriegs aus der Ukraine. Mit unserem Unterstützungspartner 2GETHER Spenden wir alle Werbeeinnahmen für die Menschen in der Ukraine. Mehr Infos und Spenden unter: 2gether.gg (Betterplace.org) +++ Werbung +++ Der GT Talk auf meinsportpodcast.de wird dir präsentiert von Virtual Racing School. Alle Informationen zu Hardware und zu 1:1 Coaching unter  virtualracingschool.com/ Folgt diesem Podcast auf Spotify, Audio Now oder in deiner Podcast-App der Wahl.   +++Social Media+++ Linktree Facebook  Twitter  Instagram  Moderation: Luca Storms Redaktion: Helmut Storms und meinsportpodcast.de Du möchtest deinen Podcast auch kostenlos hosten und damit Geld verdienen? Dann schaue auf www.kostenlos-hosten.de und informiere dich. Dort erhältst du alle Informationen zu unseren kostenlosen Podcast-Hosting-Angeboten.

Vacation and Short-Term Rental Titans
Vacation and Short-Term Rental Titans: Antonio Bortolotti

Vacation and Short-Term Rental Titans

Play Episode Listen Later Jul 28, 2022 24:40


In this episode of Vacation and Short-Term Rental Titans, Leo Walton (co-founder of SUPERHOG) has the pleasure of talking to Antonio Bortolotti, the Host of the Vacation Rental World Summit. First held in 2014, the Vacation Rental World Summit is a highly productive, engaging, and truly unique, memorable live event and online platform that allows viewers to learn quickly, adopt highly effective practices and improve their Vacation Rental Business overall performance. The live event adds an unforgettable layer of personal interaction with the most forward-thinking and inspiring peers in the industry. Antonio tells us about this year's VRWS lineup and the topics that will be discussed. With some fascinating talks scheduled, this year is certainly not one to miss! Antonio explains what sets VRWS apart from other vacation rental events and how the format has been optimized to allow property managers of different sizes and different geographical territories to share their experiences and help each other develop.

Porschesport Podcast
Steve Bortolotti | Leading Porsche's new IMSA powerhouse

Porschesport Podcast

Play Episode Listen Later Jul 22, 2022 35:49


Pfaff Motorsports is one of the most successful sportscar racing teams in North America over the past decade. The team has led over 5,000 laps, achieved 36 pole positions, amassed 35 race wins and seven championships, a record of achievement capped by the 2021 IMSA WeatherTech GTD championship and a win at the 2022 Rolex 24 at Daytona.

the no BS short-term rental podcast
Common Sense Is Not Common Practice with Antonio Bortolotti

the no BS short-term rental podcast

Play Episode Listen Later Jun 30, 2022 54:02


On today's episode, John and Mateo sit down with Antonio Bortolotti, the founder of Vacation Rental Secrets and host of the Vacation Rental World Summit. Antonio's start in the industry is unlike any other we have spoken to. A commercial airline pilot for almost 4 years up until the tragic event of 9/11 where he then developed a fear of flying. Looking for an exit and where to go next he began purchasing short-term rentals. In 3 years, he purchased and brought three dilapidated properties to profit. Antonio was self-taught in every aspect of vacation rentals and began building websites, consulting, and speaking at HomeAway events where he would share his insights with property managers. Antonio has always found joy in helping others and providing value wherever he can so he created his own industry event. The first summit was virtual where he attracted 15,000 attendees in just 3 days spanning 49 countries. Ever since then he's been sharing his secrets about the industry with property managers all over the world. Such a positive man and an interview you do not want to miss!

the no BS short-term rental podcast
Common Sense Is Not Common Practice with Antonio Bortolotti

the no BS short-term rental podcast

Play Episode Listen Later Jun 30, 2022 54:02


On today's episode, John and Mateo sit down with Antonio Bortolotti, the founder of Vacation Rental Secrets and host of the Vacation Rental World Summit. Antonio's start in the industry is unlike any other we have spoken to. A commercial airline pilot for almost 4 years up until the tragic event of 9/11 where he then developed a fear of flying. Looking for an exit and where to go next he began purchasing short-term rentals. In 3 years, he purchased and brought three dilapidated properties to profit. Antonio was self-taught in every aspect of vacation rentals and began building websites, consulting, and speaking at HomeAway events where he would share his insights with property managers. Antonio has always found joy in helping others and providing value wherever he can so he created his own industry event. The first summit was virtual where he attracted 15,000 attendees in just 3 days spanning 49 countries. Ever since then he's been sharing his secrets about the industry with property managers all over the world. Such a positive man and an interview you do not want to miss! Learn more about your ad choices. Visit megaphone.fm/adchoices

Jogo Político
#189 - PDT pode antecipar para junho escolha do candidato no Ceará

Jogo Político

Play Episode Listen Later Jun 8, 2022 63:02


As recentes tensões entre apoiadores da governadora Izolda Cela e do ex-prefeitos Roberto Cláudio devem fazer o grupo Ferreira Gomes alterar uma tradição na definição de candidaturas: deixar essa escolha para o prazo final das convenções partidárias. Foi assim com Camilo Santana (PT) em 2014, foi assim com José Sarto (PDT) em 2020. A avaliação é que as disputas internas já passaram do ponto, e o melhor é definir logo o nome para evitar fissuras ainda mais profundas. É realmente o melhor a se fazer? O PDT sairá unido e fortalecido desse processo? O que deu errado nesse planejamento eleitoral? Para responder a essas e outras perguntas, o episódio #190 do podcast Jogo Político recebe os jornalistas Guálter George, Ítalo Coriolano e Plínio Bortolotti.

Cash is school
# 11 L'interview cash avec Alex Bortolotti- Le leader de l'information sur Wordpress-

Cash is school

Play Episode Listen Later Jun 3, 2022 55:35


Aujourd'hui, j'accueille Alex Bortolotti. C'est un créateur de site via Wordpresse. Il a créé le site WPMarmitte.com qui est consacré à Worpress. De plus, il aide à être autonome sur Wordpress en tant que formateur sur le site Wpchef.fr. Dans ce podcast, il nous explique cette passion pour Wordpress ainsi que son parcours professionnel. Si vous avez envie de découvrir un peu plus sur lui, il y a son site internet alexborto.com et il fait des vidéos youtube alexborto.

NippurCast
#41 Nippur Talks - Rafael Bortolotti

NippurCast

Play Episode Listen Later May 18, 2022 42:20


Neste episódio apresentado pelo nosso Head Nippur Direct, Renan Hack, conversamos com nosso assessor de investimentos, Rafael Bortolotti.

neste bortolotti nippur
il posto delle parole
Nicoletta Bortolotti "Disegnavo pappagalli verdi alla fermata del metrò"

il posto delle parole

Play Episode Listen Later Apr 2, 2022 27:13


Nicoletta Bortolotti"Disegnavo pappagalli verdi alla fermata del metrò"La storia di Ahmed MalisGiunti Editorehttps://www.giunti.it/Una storia di riscatto, solidarietà e tenacia: perché solo quando ci crediamo fino in fondo, i sogni possono diventare realtà. Ahmed Malis, un ragazzo di origine egiziana, figlio di genitori immigrati a Milano negli anni Ottanta, ama disegnare ed è un vero prodigio autodidatta. La sua famiglia, però, non ha abbastanza disponibilità economica per mandarlo all'Accademia d'arte e sogna per lui un futuro solido, non certo da artista. Ahmed frequenta insieme ai suoi fratelli il centro di aggregazione giovanile CDE Creta, molto attivo nel quartiere milanese del Giambellino. Proprio qui, grazie all'iniziativa di un educatore che più di tutto vuole dare una chance a questi adolescenti spesso allo sbando, Ahmed riesce a pubblicare i suoi disegni sul Corriere.it e a realizzare il suo sogno. I disegni della copertina e degli interni sono di Ahmed Malis.Nicoletta Bortolotti nasce in Svizzera, ma vive in Italia. Laureata in pedagogia, redattrice Mondadori, autrice per ragazzi e per adulti, incontra studenti nelle scuole di tutta Italia e della Svizzera. Ha pubblicato per Sperling & Kupfer Il filo di Cloe ed E qualcosa rimane (premio Carver e Leonforte); per Mondadori Sulle onde della libertà; per Einaudi ragazzi In piedi nella neve (premio Gigante delle Langhe e premio Cento), Oskar Schindler Il Giusto e La bugia che salvò il mondo. Per Harper & Collins Chiamami sottovoce (premio Alvaro Bigiaretti e Giuditta), grazie al quale è stato girato un docufilm per Rai 3.IL POSTO DELLE PAROLEascoltare fa pensarehttps://ilpostodelleparole.it/

GuestX Podcast
Virtual Solutions with Antonio Bortolotti

GuestX Podcast

Play Episode Listen Later Nov 10, 2021 16:22


Join Matthew and Brian from the 2021 Vitur Summit with Antonio Bortolotti, host of the Vacation Rental World Summit. Antonio emphasizes the importance of virtual concierge and home automation solutions and talks about how they impact the guest experience. He also shares the new format of the Vacation Rental World Summit and how it brings property managers and owners together from all over the world. Learn more about your ad choices. Visit megaphone.fm/adchoices

virtual bortolotti
Shoot Like A Girl
Episode 12: S1 Claire Bortolotti

Shoot Like A Girl

Play Episode Listen Later Aug 24, 2021 48:28


S1 Claire Bortolotti worked as a paramedic before joining the Canadian Armed Forces as a Medical Technician. Looking for more action and excitement, she completed a very difficult selection followed by a year long course to become a Clearance Diver in the Royal Canadian Navy. She has also competed internationally as a swimmer representing Canada at the World Military Games. ---------- instagram.com/shootlikeagirlpodcast/ shootlikeagirlpodcast@gmail.com

New York Style Guide
Lamborghini kicks off International GT Open season with victory

New York Style Guide

Play Episode Listen Later May 16, 2021


Lamborghini kicks off International GT Open season with victory and points lead Schandorff and Beretta lead VS Racing one-two in second Paul Ricard race Lamborghini also claims GT Open Am class one-two result Podium for factory drivers Bortolotti and Costa in GT Masters opener at Oschersleben Lamborghini recorded a sensational one-two finish on the opening ...

CARRY ON
Der Diplomat - Mirko Bortolotti

CARRY ON

Play Episode Listen Later Dec 26, 2020 31:12


Wir hatten diese Woche einen sehr "schnellen" Gast. Unglaublich, was Mirko Bortolotti schon alles in seinem jungen Leben erreicht hat. Zudem ist sein Wechsel von Audi zu Lamborghini natürlich eine häufige Frage von unseren Usern gewesen. Was Marc und Mirko in einem Restaurant am Nürburgring passiert ist, wird am Ende aufgeklärt... - also hört rein und Wir wünschen Euch einen guten Rutsch ins Jahr 2021! Bleibt gesund. hdgdl Carrie und Marc

The MoneySaver Podcast
Exchange Traded Funds (ETFs) - What You Need to Know

The MoneySaver Podcast

Play Episode Listen Later Jun 10, 2019 40:43


In episode #22 of the MoneySaver Podcast, we chat with Dan Bortolotti, blogger, financial planner and podcast host of the Canadian Couch Potato about exchange traded funds (ETFs), index investing, passive vs active investing and all-in-one ETFs. Questions Asked: 0:56 Tell us a little bit about what got you interested in the couch potato approach to investing. 3:02 You won a Globe and Mail award for The Couch Potato blog. 3:50 Can you explain index investing?  Why is it lower cost? What is the difference between passive and active? 7:58 What has held index funds back? 11:59 What made you decide to take the leap from being a full time journalist to a financial advisor? 17:18 What do you think about the growth in actively managed ETFs? 20:54 What do you think of the advent of robo-advisors as a way to fill the market gap for individuals who do not want to do the work on their own? 27:02 The newest product is the all in one ETF portfolio priced really low which seems to give you a lot of advantages of a robo-advisor.  What do you think of those? 36:00 What are three tips that are essential for Canadians to consider when they're thinking about investing.

Circulation on the Run
Circulation October 17, 2017 Issue

Circulation on the Run

Play Episode Listen Later Oct 16, 2017 21:22


Dr. Carolyn Lam:               Welcome to Circulation on the Run, your weekly podcast summary and backstage pass to the journal and its editors. I'm Dr. Carolyn Lam, associate editor from the National Heart Center and Duke National University of Singapore.                                                 Our feature discussion this week centers on the temporal changes in natriuretic peptides preceding heart failure hospitalizations and patients at high risk. Data that are really novel and have implications for the way we perhaps monitor and categorize these high risk patients. Well, more soon right after these summaries.                                                 The first original paper this week provides the first epigenome-wide association study in patients with heart failure. Now, epigenetics refers to biochemical DNA modification such as methylation of gene bodies, and post-translational modification of histones, which is increasingly recognized to play a crucial, regulatory interface between genes, environment, and the transcriptome.                                                 The lack of availability of myocardial specimens from patients has been a major roadblock for elucidating the impact of such epigenetic changes on complex cardiovascular traits. However, in today's paper from first author, Dr. Meder, corresponding author, Dr. Katiz and colleagues from University of Heidelberg, Germany. The authors performed the first multi-omic study in myocardial tissue and blood of patients with dilated cardiomyopathy compared to controls.                                                 They detected 59 epigenetic loci that are significantly associated with dilated cardiomyopathy, with three of them reaching epigenome-wide significance. 29 of these loci could be replicated in independent cohorts and authors further linked a subset of 517 epigenetic loci with dilated cardiomyopathy and cardiac gene expression.                                                 Finally, they identified distinct epigenetic methylation patterns that are conserved across tissues. Thus representing novel, epigenetic biomarkers for heart failure.                                                 The next study is the first to assess a diagnostic and prognostic value of cardiac myosin binding protein-C in patients presented with possible acute myocardial infarction or AMI. Cardiac myosin binding protein-C is a cardiac restricted protein that is more abundant than the cardiac troponins and is released more rapidly following AMI.                                                 In today's paper, first author, Dr. Kaya, corresponding author, Dr. Marber and colleagues from the Rayne Institute In St. Thomas's hospital in London evaluated cardiac myosin binding protein-C as an adjunct or alternative to cardiac troponins in the early diagnosis of AMI in 1,954 unselected patients presenting to the emergency department with symptoms suggestive of AMI.                                                 The final diagnosis of AMI was independently adjudicated in 340 patients. The authors found that concentrations of cardiac myosin binding protein-C at presentation were significantly higher in those with versus without an AMI. The discriminatory power for AMI quantified by the area under receiver operating curve was comparable for cardiac myosin binding protein-C to high sensitivity cardiac troponins T and I, and even superior to standard sensitivity cardiac troponin I. The use of cardiac myosin binding protein-C more accurately classified patients with a single blood test and to rule out or rule in categories in early presenters, meaning those with chest pain of less than three hours.                                                 The improvement in rule in or rule out classification with cardiac myosin binding protein-C was larger compared with higher sensitivity cardiac troponins T and I. Finally, cardiac myosin binding protein-C was superior to high sensitivity and standard troponin I and similar to high sensitivity cardiac troponin T at predicting death at three years. Thus in summary, this paper shows that cardiac myosin binding protein-C at presentation provides discriminatory power comparable to high sensitivity troponins T and I in the diagnosis of AMI and may perform favorably in patients presenting early after symptom onset.                                                 The next paper describes the discovery of a novel candidate cardiomyopathy or arrhythmia gene. First author, Dr. Barryfield, corresponding author Dr. McNally from Center of Genetic Medicine in Chicago and colleagues studied a family with dilated cardiomyopathy and associated conducted system disease in whom prior clinical cardiac gene panel testing was unrevealing. Whole genome sequencing however, identified a premature stop codon in the gene encoding a novel myo filament component, the myosin binding protein-H-like.                                                 Having identified this gene, they turned to experimental approaches. The myosin binding protein-H-like gene was found to have high atrial expression with low ventricular expression. The truncated protein failed to incorporate into the myo filament. Human cell modeling demonstrated reduced expression of the mutant allele. Heterozygotes and nullumites exhibited a reduction in fractional shortening and increased diastolic ventricular chamber size, aberrant atrio-ventricular conduction and an increased rate of arrhythmia associated with the expression of the myosin binding protein-H-like in the atria, as well as in discrete puncta throughout the right ventricular wall and septum.                                                 These findings therefore support that myosin binding protein-H-like truncations may increase the risk for human arrhythmias and cardiomyopathy.                                                 Transplantation of cells into the infarctant heart has significant potential to improve myocardial recovery. However, low efficacy of cell engraftments still limits the therapeutic benefit. In today's paper, authors describe a method for the unbiased, in-vivo selection of cytokines that may improve Mesenchymal stromal cell engraftment into the heart. In this paper from first author, Dr. Bortolotti, corresponding author Dr. Giacca, and colleagues from University of Trieste in Italy, an arrayed library of 80 secreted factors were individually cloned into adeno-associated viral vectors.                                                 Pools from this library were then used for the batch transduction of bone marrow derived Mesenchymal stromal cells ex-vivo, followed by intra myocardial cell administration in normal and infarctant mice. Three weeks after injection, the vector genomes were recovered from the few persisting cells, and identified by sequencing DNA barcodes that were uniquely labeled for each of the tested cytokines.                                                 Using this novel, competitive, engraftment screening methodology, the authors identified that the most effective molecule was cardiotrophin-1 a member of the IL-6 family. Intra cardiac injection of Mesenchymal stromal cells preconditioned with cardiotrophin-1 preserved cardiac function and reduced infarct size parallel to the persistence of the transplanted cells in the healing hearts for at least two months after injection. Thus, preconditioning with cardiotrophin-1 might represent an efficient manner to improve the currently poor cell retention in patients treated with Mesenchymal stromal cell therapy.                                                 The final paper presents results of the early myo trial, a non-inferiority trial comparing a pharmacoinvasive strategy with half-dose alteplase versus primary PCI in patients with STEMI, presenting six hours or less after symptom onset but with an unexpected PCI related delay.                                                 First author, Dr. Poole, corresponding author, Dr. Hua and colleagues from Shanghai Jiao Tong University in China randomized a total of 344 patients from seven centers to a pharmacoinvasive arm or a primary PCI arm. They found that pharmacoinvasive strategy was non-inferior to primary PCI for the primary endpoint of complete epicardial and myocardial reperfusion after PCI defined as TIMI flow grade 3, TIMI myocardial profusion grade 3, and ST-segment resolution of more than 70%.                                                 There was no significant differences in the frequency of the individual components of the combined endpoint. Infarct size and left ventricular ejection fraction were similar in both groups and there was no significant differences in 30-day rates of total death, re-infarction, heart failure, major bleeding events, or intracranial hemorrhage. However, minor bleeding was observed more often in the pharmacoinvasive group.                                                 Thus the authors concluded that a pharmacoinvasive approach with reduced dose alteplase seems to offer effective and safe reperfusion in low-risk patients with STEMI with an unexpected PCI related delay. Further large, randomized control trials powered for clinical endpoints are needed.                                                 Well, that wraps it up for your summaries. Now for our feature discussion.                                                 The measurement of natriuretic peptides BNP, NT-proNP have certainly become the cornerstone of heart failure management. We measure these levels by guidelines in patients who are presenting with symptoms and suspected heart failure, in patients who are hospitalized. We measure them for prognostication purposes at discharge. However, what we don't really know is how the preceding changes in natriuretic peptides may precede heart failure hospitalization in patients who are at high risk of developing heart failure.                                                 For example, patients with a recent coronary event or type-2 diabetes. And this is the very subject of our feature paper today, and I am so pleased to have the corresponding author of today's paper which is really a research letter. Dr. Brian Claggett from Brigham and Women's Hospital as well as Dr. Biykem Bozkurt who's our senior editor from Baylor College of Medicine.                                                 Welcome both, and maybe I could start, Biykem could you let us know, what are the unanswered questions in heart failure relating to natriuretic peptides and how do you see this paper falling in, clinically? Dr. Biykem Bozkurt:        Carolyn, this is a wonderful I think prelude to perhaps preventing heart failure events. And as you are aware, we in the recent year changed our guidelines at the ACC, AHA, and the HFSA incorporating screening high risk patients for development of incident heart failure. And the study that resulted in this consideration was a STOP-HF trial which was utilizing natriuretic peptides in high risk patients to determine whether their closer follow up in a multidisciplinary fashion would result in earlier detection and prevention of heart failure, and which it did.                                                 And this study I think is straddling the concept of high risk or stage A or B patients because they are individuals who have had heart attacks, coronary events, and they have type-2 diabetes so they are definitely high risk. And doing natriuretic peptides as an outpatient, whether that would predict the heart failure hospitalizations.                                                 And in essence I think it's a good concept. Perhaps the challenging concepts are how often should we screen our patients, and what will be the threshold of the rise that would potentially make us act in either earlier diagnostic strategies, or management strategies. I think those are the two unanswered questions that remains.                                                 How are we gonna screen our patients? Our high risk patients to determine when they are developing heart failure before they become symptomatic? So, what threshold are we going to use? Dr. Carolyn Lam:               That is a perfect set up. I just wanted to add as well in addition to STOP-HF there was the PONTIAC study in diabetics which is very relevant to today's paper that also sort of used NT-proBNP to risk stratify patients for prevention of heart failure. But neither of these studies talked about the temporal changes in natriuretic peptides. And I think a lot of the reason for that is, is that the methods, I mean the statistical methods to do that sort of thing are mind-blowing.                                                 And so Brian, could you now please share with us what you did, the methodology and basically what you found before we discuss the two questions that Biykem brought up? Dr. Brian Claggett:           What was really interesting is the method that we came up with to look at these questions. It's something that we like to believe will be generalizable and can be used in other scenarios and for other biomarkers. But the idea that we have is that we are always used to thinking about the design of a clinical trial as being very regimented. So, you see a patient once at baseline, and then maybe six months later, and then maybe six months after that, and so on. And so it's hard to know what's going on, on a day to day or week to week basis.                                                 But if you think backwards, and you think backwards from the time of any sort of event, because those events whether they're hospitalizations or MIs or death, they happen not on that same schedule. And so odds are at the end of a trial, you had a patient who came to a scheduled visit and then had an event the next day. And you probably had a patient who came in for a visit two days before an event, and another patient who came in a week before an event. So if you start thinking on that time scale, you can piece together all these different time frames when you do have data collected and try to reconstruct something that looks like an actual continuous natural history of what that biomarker would have looked like over say a two year period, if it had been measured continuously. Dr. Carolyn Lam:               So, tell us what you found. First of all, let's just make sure that everyone knows you were looking at the ELIXA cohort, right? Dr. Brian Claggett:           Yes, the data that we had available for this analysis comes from the ELIXA trials, it was 6,068 patients all with type-2 diabetes and a recent ACS event. Recent meaning within the last 180 days. And they were randomized placebo versus a diabetes drug, lixisenatide. And they were followed up for cardiac outcomes.                                                 Beyond that, the natriuretic peptides were measure systematically at baseline, month 6, month 18, and month 24 in all patients who were participating in the trial. So this was the richest collection of a large number of patients being measured multiple times, systematically and not in just a sub-sample of the population. So, we felt like this was a great opportunity to learn something about what happens. What can you learn when you measure these natriuretic peptides over and over again.                                                 And even more interesting than that, the fact that this wasn't a heart failure trial meant that some of the patients already had heart failure at baseline. Other patients didn't have heart failure, but as the trial went on, they developed or were hospitalized for heart failure for the first time. And so we were able to also look at differences between patients experiencing their first heart failure, versus those with more long standing disease. Dr. Carolyn Lam:               And that was very, very unique methodology that you spoke about. And I fully agree that it's going to be used more. I am staring at your beautiful figure one right now. That really, really says it all. Could you walk us through the results? Dr. Brian Claggett:           Sure, I think our key finding is that, I guess no matter when you measure patients. Patients with a higher level of NT-proBNP, or a higher level of BNP at any given time are going to be at higher risk of developing heart failure in the future.                                                 But as we start looking at this as a temporal process, what we see is that there seem to be a noticeable acceleration in these increases, specifically in the last six months before development of heart failure. Or, before a hospitalization for heart failure. And that increase in the final six months seems to occur both in patients who had no prior history of heart failure and also in patients with a history of heart failure. So that six month window I think is something that we learned that we didn't necessarily know before. Dr. Carolyn Lam:               But, going back to Biykem's questions, do you think we have answers to how often we need to survey natriuretic peptides in these high risk patients and what threshold we need to act on? Dr. Brian Claggett:           I think both are very important. I think maybe the timing and the thresholds are somewhat separate questions. I think we're better able to answer the timing question. At the very least we can say that if dramatic changes are happening over a six month window that measuring patients only once every six months probably isn't enough. Whether that means it needs to be every three months, or two months, or one month, or something more than that, I think it's hard to know exactly what the right answer is. But I think we are confident in saying that things happen relatively quickly and we need to be measuring these things more frequently.                                                 As far as the question of thresholds, I think that's maybe even a more difficult question. Or even the idea of a threshold means that we think that there's some magic number and I am not sure that we know for sure what's more important, the absolute number or is it the ... if someone starts relatively low and that relatively low number doubles over the course of six months. That might still be prognostically just as important as someone who's been consistently edging just below or just about that threshold level.                                                 I'm not sure that we're confident enough to say that the changes, the speed of the changes, or the relative changes, or some absolute threshold is the most important thing to be paying attention to. But, I think where these two are related is the more ... that we can start to collect this data more frequently and be able to analyze it. I think that gives us a lot better chance of being able to successfully answer that question about thresholds. Dr. Carolyn Lam:               Indeed. Stuff for future work, huh? Biykem, what do you think? Dr. Biykem Bozkurt:        I wanted to point out two things from Brian's study which was quite interesting. One is the trajectory of the rise, or the delta changes in the natriuretic peptides was quite different in the patients with no history of heart failure compared to those with a history of heart failure. The trajectory, or the linear rise, or the delta changes were more prominent in the individuals with no history of heart failure. Probably intuitively expected so because their baseline levels are not as high as the individuals with history of heart failure.                                                 So, it almost gives the impression that maybe in low low risk, the screening or the frequency may need to be lower, and if low, then probably the likelihood of the rise may be less. But those individuals who, as you said, are edging upward, then maybe the frequency may need to be higher and there may be perhaps a linear rise or a more prominent rise about six months before the incident event.                                                 So, it's an interesting concept just to look at people's trajectories. But, as you said, probably individualization and monitoring or targeting may need to be individualized according to personal risk and other features. And one then wonders futuristically if this would be a concept that would be point of care testing maybe done by the patients similar to glucose monitoring. And in the event that we were to be able to carry the platform to self-test. Dr. Brian Claggett:           You're talking to a statistician, so I am always going to be in favor of collecting more data all the time. So I agree with that. Dr. Carolyn Lam:               Wow, what an insightful discussion. Thank you both for joining us on this podcast today.                                                 Ladies and gentlemen out there, you heard it right here in Circulation on the Run. Tune in again next week.