Podcasts about Amp

This week we discuss Programming Language Rankings, CNCF Project Velocity and the new Gartner MQ for Cloud Infrastructure. Plus, are straws really necessary? Rundown Update on CNCF and Open Source Project Velocity 2020 (https://www.cncf.io/blog/2021/08/02/update-on-cncf-and-open-source-project-velocity-2020/?utm_content=174974774&utm_medium=social&utm_source=twitter&hss_channel=tw-3286770860) Stack Overflow Developer Survey 2021 (https://insights.stackoverflow.com/survey/2021) Heroku and Digital Ocean make the Cloud Platforms list (https://insights.stackoverflow.com/survey/2021#most-popular-technologies-platform) The RedMonk Programming Language Rankings: June 2021 (https://redmonk.com/sogrady/2021/08/05/language-rankings-6-21/) AWS Named as a Leader for the 11th Consecutive Year in 2021 Gartner Magic Quadrant for Cloud Infrastructure & Platform Services (CIPS) (https://aws.amazon.com/blogs/aws/aws-named-as-a-leader-for-the-11th-consecutive-year-in-2021-gartner-magic-quadrant-for-cloud-infrastructure-platform-services-cips/) Customers warn Gartner of AWS's high-pressure sales tactics in latest verdict on public cloud providers (https://www.theregister.com/AMP/2021/08/03/gartner_verdict_on_public_cloud/) Relevant to your interests Amazon cloud revenue growth accelerates to 37% in Q2 (https://www.cnbc.com/2021/07/29/aws-earnings-q2-2021.html) Use the new Google Meet web app for better meetings on desktop devices (https://workspaceupdates.googleblog.com/2021/07/use-new-google-meet-web-app-for-better.html) The Mark Cuban-founded audio app Fireside is asking its own users to invest (https://www.theverge.com/2021/7/30/22601191/fireside-app-mark-cuban-falon-fatemi-libsyn-rode-invest) Russia hacked emails of US federal prosecutors around the country (https://twitter.com/jsrailton/status/1421315244660559874?s=20) Zoom agrees to pay $85M to settle privacy suit (https://www.axios.com/zoom-settle-85-million-privacy-suit-4674b13a-b062-46fa-b72d-32fdf62d97d1.html) Microsoft Teams rolls out native notification on its macOS app (https://9to5mac.com/2021/08/02/microsoft-teams-rolls-out-native-notification-on-its-macos-app/) Salesforce's MuleSoft buys RPA specialist Servicetrace (https://siliconangle.com/2021/08/02/salesforces-mulesoft-buys-rpa-specialist-servicetrace/) Cloud Foundry Summit: Kubernetes Must Do Better by Developers (https://thenewstack.io/cloud-foundry-summit-kubernetes-must-do-better-by-developers/) IBM Cloud took the evening off – 23 services were hard to provision for eight hours (https://www.theregister.com/2021/08/03/ibm_sev_one_outages/) Red Hat OpenShift 4.8 Is Now Generally Available (https://cloud.redhat.com/blog/red-hat-openshift-4.8-is-now-generally-available) Deal Of The Century: How Michael Dell Turned His Declining PC Business Into A $40 Billion Windfall (https://www.forbes.com/sites/antoinegara/2021/08/03/deal-of-the-century-how-michael-dell-turned-his-declining-pc-business-into-40-billion-windfall/) Facebook is reportedly trying to analyze encrypted data without deciphering it | Engadget (https://www.engadget.com/facebook-analyze-encrypted-messages-ad-targeting-175739715.html) Why Nvidia's $40 billion bid for Arm could be in jeopardy (https://www.cnbc.com/amp/2021/08/04/nvidias-40-billion-bid-for-arm-could-be-in-jeopardy.html) Keeping clients of OpenSearch and Elasticsearch compatible with open source | Amazon Web Services (https://aws.amazon.com/blogs/opensource/keeping-clients-of-opensearch-and-elasticsearch-compatible-with-open-source/) Oracle launches Verrazzano container platform for Kubernetes (https://www.infoworld.com/article/3627407/oracle-launches-verrazzano-container-platform-for-kubernetes.html) Verrazzano Enterprise Container Platform (https://verrazzano.io/) Investing in Polywork - Andreessen Horowitz (https://a16z.com/2021/08/05/investing-in-polywork/) Amazon's drone project is experiencing turbulence (https://thehustle.co/08052021-Amazon-drone-project) One big tech company changes its hybrid work policy in a permanent way (https://www.bizjournals.com/sanjose/news/2021/08/02/linked-in-permanent-remote-work.html) Apple's Plan to "Think Different" About Encryption Opens a Backdoor to Your Private Life (https://www.eff.org/deeplinks/2021/08/apples-plan-think-different-about-encryption-opens-backdoor-your-private-life) LISA Community Message (https://s.usenix.org/acton/media/2452/lisa-community-announcement) Nonsense Zoom agrees to pay $85M to settle privacy suit (https://www.axios.com/zoom-settle-85-million-privacy-suit-4674b13a-b062-46fa-b72d-32fdf62d97d1.html) Goldman Sachs joins Wall Street rivals in boosting junior banker salaries (https://www.cnbc.com/2021/08/02/goldman-sachs-joins-wall-street-rivals-in-boosting-junior-banker-salaries-.html) HEB sells candles that smell like fresh tortillas, because you can't live at the stor (https://www.statesman.com/story/lifestyle/food/2021/07/27/heb-butter-tortilla-candles-texas-grocery-store-bakery-scents/5391681001/)e (https://www.statesman.com/story/lifestyle/food/2021/07/27/heb-butter-tortilla-candles-texas-grocery-store-bakery-scents/5391681001/) Sponsors strongDM — Manage and audit remote access to infrastructure. Start your free 14-day trial today at strongdm.com/SDT (http://strongdm.com/SDT) CBT Nuggets — Training available for IT Pros anytime, anywhere. Start your 7-day Free Trial today at cbtnuggets.com/sdt (https://cbtnuggets.com/sdt) Conferences SpringOne (https://springone.io), Sep 1-2 DevOps Loop | October 4, 2021 (https://devopsloop.io/?utm_campaign=Global_P6_TS_Q322_Event_DevOpsLoop_at_VMworld&utm_source=twitter&utm_medium=social) THAT Conference comes to Texas January 17-20, 2022 (https://that.us/activities/call-for-counselors/tx/2022) SDT news & hype Join us in Slack (http://www.softwaredefinedtalk.com/slack). Send your postal address to stickers@softwaredefinedtalk.com (mailto:stickers@softwaredefinedtalk.com) and we will send you free laptop stickers! Follow us on Twitch (https://www.twitch.tv/sdtpodcast), Twitter (https://twitter.com/softwaredeftalk), Instagram (https://www.instagram.com/softwaredefinedtalk/) and LinkedIn (https://www.linkedin.com/company/software-defined-talk/). Brandon built the Quick Concall iPhone App (https://itunes.apple.com/us/app/quick-concall/id1399948033?mt=8) and he wants you to buy it for $0.99. Use the code SDT to get $20 off Coté's book, (https://leanpub.com/digitalwtf/c/sdt) Digital WTF (https://leanpub.com/digitalwtf/c/sdt), so $5 total. Become a sponsor of Software Defined Talk (https://www.softwaredefinedtalk.com/ads)! Recommendations Brandon: Let Him Go (https://www.rottentomatoes.com/m/let_him_go). Matt: Cloud Native Application Flows (https://www.cloudnativeaf.com/) podcast. Coté: La Vallade (https://lavallade.nl) restaurant in Amsterdam, which serves La Pauline (https://www.wijnbeurs.nl/la-pauline-classique-merlot-cabernet) wine, which you should also try. Photo Credit (https://unsplash.com/photos/NLSvKQTJOz0) Photo Credit (https://unsplash.com/photos/qIu77BsFdds)

We had a wonderful conversation with Lisa Loeb on The Chris & Sandy Show. We talked about so many things from family, music, sacrifices, she told some amazing stories to a whole lot more.We also talked about her musical project Together Apart. Her eyewear line - lisaloebeyewear.com and her Camp Lisa Foundation - lisaloeb.com/camp-lisaDallas native Lisa Loeb is a 2018 GRAMMY Award-winning singer songwriter, touring musician and philanthropist who started her career with the platinum-selling Number 1 hit song “Stay (I Missed You)” from the film Reality Bites. A trailblazing independent artist, Lisa was the first pop musician to have a Number 1 single while not signed to a recording contract. She followed that remarkable feat with several hit singles and six albums, two which were certified gold.Lisa is also well known to parents and kids for her five children's albums and two illustrated children's books with music.  Lisa recently collaborated to develop and write the children's musical "Camp Kappawanna," which debuted at New York City's Atlantic Theater Company.  Inspired by her own love of summer camp, in 2008, Lisa started The Camp Lisa Foundation, which sends underserved kids to summer camp.  In 2015, The American Camp Association of New England named Lisa Loeb as their Camp Champions Honoree with a gala celebration at Fenway Park.Over the last three years, Lisa has released three children's albums that are exclusively available with Amazon.  In January 2018, her family friendly album, “Feel What U Feel,” won the Grammy for Best Children's Album, along with rave reviews and The Parents Choice Award.   Among other shows, Lisa provides voice talent for the animated series “Creative Galaxy” and composes the original songs for the Emmy nominated, “If You Give a Mouse a Cookie” series.  Her songs from the series make up a soundtrack album that was released in June of 2018 exclusively with Amazon.Often recognized for her iconic cat-eyed glasses, Lisa redefines how women accessorize with her own eyewear line.  As an entrepreneur, Lisa oversees the business and eyewear design of Lisa Loeb Eyewear.  It's an ever-growing collection, available at optical shops as well as Costco, where women's styles and children's frames are available.  As an actor, Lisa's recent film and television appearances include “AP Bio,” John Oliver's "Last Week Tonight," "About a Boy," "Hot Tub Time Machine 2," "King of The Nerds," and Sprout Channel's "Sunny Side Up Show” (now “Sprout House” on Universal Kids).  You might have also heard her voice on commercials including Alfa Romeo, Foster Farms Chicken and Chili's.A recent personal honor for Lisa was being asked by editor, Will Shortz, to help celebrate the 75th anniversary of The New York Times crossword by creating an original puzzle with pro, Doug Peterson.   Other recent highlights and appearances include contributing a cover version of “All the Young Dudes” for Howard Stern's David Bowie Special on Sirius XM, leading a kids' songwriting workshop in Sydney, Australia with AMP, and a two-week residency at the legendary Carlyle Hotel in New York.  Last Spring, Lisa exclusively released through Rolling Stone her cover of Bright Eyes' 'First Day of my Life,' which she recorded after performing for a friend's wedding a decade ago. And in July, she released the new track 'Love Never Dies,' an original song she wrote and recorded as a theme song to accompany acclaimed author James Patterson's latest novel, "Sophia, Princess Among Beasts."Earlier this year, Lisa released her 15th studio album, A Simple Trick to Happiness, including 11 original tracks.  When she is not at home in Los Angeles with her husband, Roey, two children, Lyla and Emet, and her cat, Sweetie McGee, Lisa enjoys performing all over the world and entertaining audiences of all ages.

Do you feel like you are trying to manage all the chaos of the world? Are there things in your life and ministry that are challenging and cause you anxiety? Are you searching for answers? Whether we face problems that need to be solved or tensions that need to be managed there are many places where we experience trouble. Marriage Relationships Ministry and church related challenges Our schedule Physical health  Emotional health Finances Kids/family There are things that contribute to our lack of peace: Messages from the world Expectations of others Taking on more things to do for God than our relationship with God can handle Busyness Fears Wrestling with challenges and being unsure of what to do Coping by grasping and clinging to other people or circumstances...even a feeling.   There is chaos around us and chaos within us. Here is where we can related to David as he expresses this shared experience in Psalm 63: My inner self thirsts for you, my flesh longs and is faint for you, in a dry and weary land where there is no water.   We desperately need peace. Where do we find it in the midst of a world that is filled with chaos and confusion? Where are you looking for peace? Peace I Leave You “I am leaving you with a gift -  peace of mind and heart. And the peace I give is a gift the world cannot give.” John 14:27 NLT   “Peace I leave with you; my [own] I now give and bequeath to you. Not as the world gives do I give to you. Do not let your hearts be troubled, neither let them be afraid. [Stop allowing yourselves to be agitated and disturbed; and do not permit yourselves to be fearful and intimidated and cowardly and unsettled.] John 14:27 AMP   Isaiah 26:3 ”You will keep in perfect peace all who trust in you, all whose thoughts are fixed on you! Trust in the LORD always, for the LORD GOD is the eternal Rock.”   The peace we so desperately crave is a peace that we can not get from the world. It comes from no place, no one, no thing, no circumstance. Peace...true, lasting, secure peace comes from God Himself. How do you allow yourself to be agitated or fearful or unsettled? What are you focused on? What are you thinking about? What are you holding onto? What or who are you trusting in? Where do you look for peace?  The power comes when you realize that regardless of what is happening around us, even how we feel, the gift of peace is still ours. Because HE is peace...He is security.  Today, let's pay attention to where we are fixing our thoughts. What are you ruminating on? What do you keep running through your mind? What do you keep watch on? Mindset Mantras are so important. It's how we keep our thoughts fixed on the Lord.   Tip of the Day Write down 3 truths from scripture about God and His promises. Every time you feel unsettled, anxious, worried, agitated, frustrated, or fearful, speak these truths. Say them out loud, repeat them silently in your heart. This is how we keep our thoughts fixed on Him and receive and accept the gift of perfect peace. Connect with Jen Facebook Instagram This episode was first published at: www.womeninministryunited.com/blog/episode103  

What a delight to share this episode with my friend and longevity superstar Dr. Robyn Benson. We discuss her work in longevity and how you can incorporate regenerative medicine techniques into your wellness routine. We summarize topics with 6 mantras that will help you to create more energy and look and feel 10 years younger. Mantra #1:  Regenerative medicine is all about getting a fresh start. Mantra #2:  Regenerative medicine is about getting more energy from your mitochondria. Mantra #3:  Regenerative medicine includes oxidative medicine which involves employing nutrition, hydration, exercise, mindfulness, and supplements to reduce oxidative stress in the body. Mantra #4: Regenerative medicine involves the detoxification of the body.   Some of Dr. Robyn's favorite tools include HBOT, sauna, cranial stimulation, and PEMF. She first measures levels of detoxification, looking at hormones, blood work, and stool analysis. See/hear my interview with Dr. Jason Sonners: https://makeeverythingfun.com/podcast/e061-jason-sonners/) See/hear my interview with Sunlighten CEO Connie Zack: https://makeeverythingfun.com/radio/e101-connie-zack/) Mantra #5: Create a self-care kit. Dr. Robyn suggests emulsified oregano oil, vitamin D, and vitamin C for starters. Dr. Robyn recommends ADP by nutribiotics research: https://shop.bioticsresearch.com/products/adp Mantra #6: Amp up your self-care and longevity routines by including cutting-edge therapies such as PRP, exosomes, ozone therapy, IV therapy, and Prolozone therapy. More about Robyn Benson Dr. Robyn Benson is a Regenerative medicine specialist, author, speaker, and founder of Santa Fe Soul Center for Regenerative Medicine and Destination Regenerate. For 28 years, she has applied her knowledge of PRP, acupuncture, herbs, IV therapies, Ozone, and leading-edge energy medicine to help patients get out of pain, restore sexual function and look and feel 10 years younger naturally. Dr. Benson is the podcast host of Younger, the Art, and Science of Youthful Aging. Robynbenson.com   Destinationregenerate.com What is fun for Dr. Robyn? ● Never evers.  Novelty, things I have never done before.    ● Hanging out with change-makers in the world ● Deep connecting with loved ones ● Dancing to 50, 60s and 70's music ● Traveling to countries exploring new cultures (food, arts....) LINKS robynbenson.com    destinationregenerate.com     Robyn all Social Media robyn@robynbenson.com www.santafesoul.com www.jointheselfcarerevolution.com www.healthytravelbook.com www.healthytravelersummit.com https://www.instagram.com/drrobynbenson/   @drrobynbenson.com https://www.facebook.com/DrRobynBenson https://www.facebook.com/robyn.benson.96?ref=profile http://www.linkedin.com/pub/robyn-benson/b/895/b8b https://twitter.com/#!/RobynBensonDOM https://www.youtube.com/user/robynbensondom https://www.pinterest.com/DrRobynDOM/ Self Care Revolution Social Media Youtube – http://www.youtube.com/user/TheSCRevolution  Facebook – https://www.facebook.com/pages/Self-Care-Revolution/484187181620202  Twitter – https://twitter.com/SelfCareRevo  LinkedIn – http://www.linkedin.com/company/join-the-self-care-revolution

Welcome to the show.  You are in for quite a treat today! With me on the show is my amazing friend, April Meese who is an incredibly talented businesswoman who can teach you how to take your business to the next level in big ways. Today, April and I are focusing on her expertise in getting publicity for your business.  April has packed today's episode with so much great content when it comes to getting your name or your business in front of your ideal client. April and talk about her signature method for gaining publicity, why publicity is so important, exact steps to take to get visible and so much more! You don't want to miss this episode.   Guest Bio April Meese has been an aesthetician since 2001 and a permanent cosmetic professional since 2005.  She's traveled internationally as a skincare speaker and addressed worldwide audiences with a special television appearance on the Dr. Oz Show in 2010, as well as a skincare expert on QVC. Ms. Meese opened Enhancing Beauty in New York City and quickly grew the business to a multiple 6-figure permanent cosmetic business, while only working part-time 3-days a week.  April was soon elected to the SPCP Board of Directors and later received the SPCP Ambassador Award in 2017 for her continued industry assistance.   Putting her business degree and marketing minor to good use, April founded the online marketing program Elevate Your Beauty Business where she helps PMU professionals increase their income up to 50% with the AMP-lify method. She is also the host of the “Beauty Marketing Simplified” Podcast.  Her passion is helping other female entrepreneurs around the world so that you can increase your income and impact with less stress.  You can find April: www.aprilmeese.com https://www.instagram.com/aprilmeeseinc/  https://www.aprilmeese.com/media 

Today's blockchain and cryptocurrency news Brought to you by ungrocery.com Bitcoin is down 1% at $39,641 Ethereum is down 1% at $2,290 and Binance Coin is down 1% at $311 Quant Network up 38% Terra up 18% Amp up 16% Robinhood IPO. Lending platform Vauld raised $25M. Uniswap deletes video from EthCC conference that suggested partnerships. Coke creates first brand inspired collection of NFTs. The Dallas Symphony Orchestra is releasing classical music NFTs on Rarible.

Join “The Sisterhood Friendship Table”. In this 13th episode (recorded on 10th June 2021), Bobbie entrusts the conversation to host Bec Wood, along with Laura Toggs, Chris Jury and Michelle Andrew as they continue the conversation around “contentment” while unpacking Philippians 4:11-13 (AMP). “Not that I speak from [any personal] need, for I have learned to be content [and self-sufficient through Christ, satisfied to the point where I am not disturbed or uneasy] regardless of my circumstances.  I know how to get along and live humbly [in difficult times], and I also know how to enjoy abundance and live in prosperity. In any and every circumstance I have learned the secret [of facing life], whether well-fed or going hungry, whether having an abundance or being in need. I can do all things [which He has called me to do] through Him who strengthens and empowers me [to fulfill His purpose—I am self-sufficient in Christ's sufficiency; I am ready for anything and equal to anything through Him who infuses me with inner strength and confident peace.]” There's nothing like gathering around the table with friends and you have a place here at our table. You're invited to join us every Thursday LIVE 10am AEST on https://hillsong.com/online​ or catch up on demand at https://www.youtube.com/hillsong ____ If you made a decision, please visit https://hillsong.com/jesus If you are in need of help or would like to chat to a Pastor, please visit https://hillsong.com/online/help ____ Connect with @BobbieHouston and the @ColourSisterhood on Instagram and Facebook.

ASIC chair Joe Longo says confronting the pandemic and easing the escalating economic crisis is the biggest immediate challenge for the corporate regulator, saying it's "all hands on deck". In an exclusive interview, Mr Longo defended ASIC's decision to scrap its criminal pursuit of wealth manager AMP and warns the rise of cryptocurrencies is "a significant area for concern".

Amp stops by and talks about kink festivals, hanky code, and leather pageants, Welcome to Messy.

Aaron Alexander is one of the foremost experts on how to utilize the body to improve all aspects of your life. He is the host of the Align Podcast and the author of The Align Method: 5 Movement Principles for a Stronger Body, Sharper Mind, and Stress-Proof Life. As a holistic performance coach, he has helped thousands of people, including some of the world's best athletes and celebrities optimize the function of their body. In this podcast, we talk about myriad ways to tap into the innate healing capacities of our bodies and find medicine in the mundane.   Get Aaron Alexander's book The Align Method | https://alignpodcast.com/align-method/   Connect With Aaron Alexander: Website | Aligntherapy.com Instagram | https://www.instagram.com/alignpodcast/?hl=en Twitter | https://twitter.com/alignpodcast?lang=en Facebook | https://www.facebook.com/AlignMovement/ Youtube | https://www.youtube.com/channel/UC6egNlsOB3AfgLsvNR4zXCA   This episode is sponsored by:   Fit For Service Mastermind | aubreymarcus.com/fitforservice   Onnit Get 10% off Onnit products |  https://www.onnit.com/Aubrey/   LUCY.CO Get %20 off Lucy Nicotine Gum | LUCY.CO and use the promo code AMP at checkout   Connect with Aubrey: Website | https://www.aubreymarcus.com/ Instagram | https://www.instagram.com/aubreymarcus/ Twitter | https://twitter.com/aubreymarcus Facebook | https://www.facebook.com/AubreyMarcus/ YouTube | https://bit.ly/2DLctpk   Check out  Own The Day Own Your Life by Aubrey Marcus|  https://bit.ly/2t6x4hu   Subscribe to the Aubrey Marcus Newsletter:  https://www.aubreymarcus.com/pages/email   Subscribe to the Aubrey Marcus Podcast: iTunes | https://apple.co/2lMZRCn Spotify | https://spoti.fi/2EaELZO Stitcher | https://bit.ly/2G8ccJt IHeartRadio | https://ihr.fm/397Msh0 Google Podcasts | https://bit.ly/3nzCJEh Android | https://bit.ly/2OQeBQg

The Bo Brothers sat down with Wally Dant with Dant Crossing to get an update on the progress being made at Nelson County's newest Bourbon Destination in Gethsemane Kentucky!  And for the first time, Jim Bo and JBow talk with Nelson County's Economic Development Super Star Kim Huston and learn about why Bardstown and Nelson County are truly the Bourbon Capital of the World!  You can find out just how excited Kim is about Dant Crossing and what this means to not only Nelson County but specifically to the New Haven/New Hope communities!  The Bo Brothers also find out about the idea that Kim had for Dant Crossing which will bring a first of its kind addition to Kentucky's favorite bourbon destination!  While you're listening, you can hear about the first release of Log Still Distillery's bourbon -- Monks Road, why Wally didn't just stop with the resurrection of the famous Dant Family distillery but his vision was to truly make the hallowed grounds into a one of a kind Bourbon family destination.  Also, you can hear about the many talented music acts that will make their way to South Western Nelson County and perform at the brand new outdoor Amphitheater affectionately called The Amp!  So much to listen to so sit back and pour a glass of Monks Road and take a listen! #MonksRoad #LogStill #DantCrossing #KimHustonIsASuperStar #Bourbon #TastingRoom #TheLegacy #47&Poplar #NewHavenKY #NewHopeKY #Family #EveryBodyLovesTheDantFamily www.dantcrossing www.logstilldistillery.com

Mensagens bíblicas ministradas nos encontros do ministério AMP, nos cultos de oração ou dominicais da Primeira Igreja Batista de Fortaleza. Nos encontramos todos os sábados às 19h (AMP). Siga nossas redes sociais @somosamp

Red and processed meat linked to increased risk of heart disease, study shows Oxford University, July 21, 2021 Globally, coronary heart diseases (caused by narrowed arteries that supply the heart with blood) claim nearly nine million lives each year1, the largest of any disease, and present a huge burden to health systems. Until now, it has been unclear whether eating meat increases the risk of heart disease, and if this varies for different kinds of meat. Researchers at the University of Oxford's Nuffield Department of Population Health have conducted the largest systematic review of the prospective evidence to date, including thirteen cohort studies involving over 1.4 million people. The study participants completed detailed dietary assessments, and their health was tracked for up to 30 years. The results are published today in Critical Reviews in Food Science and Nutrition. Overall, the evidence from the analysis indicated that: Each 50 g/day higher intake of processed meat (e.g. bacon, ham, and sausages) increased the risk of coronary heart disease by 18%. Each 50 g/day higher intake of unprocessed red meat (such as beef, lamb and pork) increased the risk of coronary heart disease by 9%. There was no clear link between eating poultry (such as chicken and turkey) and an increased risk of coronary heart disease. The findings may be because of the high content of saturated fat in red meat, and of sodium (salt) in processed meat. High intakes of saturated fat increase levels of harmful low-density lipoprotein (LDL) cholesterol, whilst excess salt consumption raises blood pressure. Both LDL cholesterol and high blood pressure are well-established risk factors for coronary heart disease. Previous work from the same research team has also indicated that even moderate intakes of red and processed meat are associated with increased risk of bowel cancer2. Dr. Keren Papier (Nuffield Department of Population Health), co-lead author of the study, said: "Red and processed meat have been consistently linked with bowel cancer and our findings suggest an additional role in heart disease. Therefore, current recommendations to limit red and processed meat consumption may also assist with the prevention of coronary heart disease." Dr. Anika Knüppel, from the Nuffield Department of Population Health and the other co-lead author of the study, added: "We know that meat production is a major contributor to greenhouse gas emissions and we need to reduce meat production and thereby consumption to benefit the environment. Our study shows that a reduction in red and processed meat intake would bring personal health benefits too." Currently in the UK, about 10 in 100 people would be expected to eventually die from coronary heart disease. Based on the findings from the present study and current red and processed meat intakes in the UK,4 if all these 100 people reduced their unprocessed red meat intake by three-quarters (for example from four times a week to one time a week), or if they stopped consuming processed meat altogether, deaths from coronary heart disease would decrease from 10 in 100 down to 9 in 100. The studies involved in this analysis were mostly based on white adults living in Europe or the U.S.. The research team say more data are needed to examine these associations in other populations, including East Asia and Africa.   C is for Vitamin C -- a key ingredient for immune cell function Harnessing the combined power of Vitamin C and TET proteins may give scientists a leg up in treating autoimmune diseases   La Jolla Institute for Immunology and Emory University, July 22, 2021 You can't make a banana split without bananas. And you can't generate stable regulatory T cells without Vitamin C or enzymes called TET proteins, it appears.  Regulatory T cells (Tregs) help control inflammation and autoimmunity in the body. Tregs are so important, in fact, that scientists are working to generate stable induced Tregs (iTregs) in vitro for use as treatments for autoimmune diseases as well as rejection to transplanted organs. Unfortunately, it has proven difficult to find the right molecular ingredients to induce stable iTregs. Now scientists at La Jolla Institute for Immunology and Emory University School of Medicine report that Vitamin C and TET proteins can work together to give Tregs their life-saving power.  "Vitamin C can be used to stabilize iTregs generated in vitro," says LJI Instructor Xiaojing Yue, Ph.D., who served as co-first author for the EMBO Reports study. "We hope that these kinds of induced Tregs can be used in the future for treatment of autoimmune diseases and organ transplantation." The recent study, led by LJI Professor Anjana Rao, Ph.D., and Emory Instructor Benjamin G Barwick, Ph.D., builds on the previous discovery that Vitamin C can enhance the enzymatic activity of TET proteins and prompt the generation of stable iTregs under lab conditions. This finding was encouraging, but the scientists did not want to work toward new autoimmune therapies without first analyzing the gene expression patterns and other key epigenetic features of the induced Tregs.  "We wanted to study the entire system at a whole genome level using next generation sequencing technology to better understand the molecular features of these cells," says Yue. Study co-first author Daniela Samaniego-Castruita, a graduate student at LJI, spearheaded the analysis of gene expression and epigenetic changes in the iTregs. A major type of epigenetic modification involves the DNA itself through the addition or removal of molecules called methyl groups from cytosines, one of the four DNA bases. The methyl groups can be further oxidized by TET enzymes. All of these interactions can eventually change how cells "read" the DNA code.  Another type of epigenetic change involves the alteration of DNA accessibility: whether DNA is loosely or tightly coiled. As the DNA coils unwind, regulatory regions become exposed which subsequently influence gene expression. In their analysis, the researchers found TET proteins are absolutely required for maintaining the gene expression and epigenetic features that make Tregs as what they are; and adding Vitamin C led to iTregs with similar similar gene expression and epigenetic features as normal "wild type" Tregs found in the body. The study also reveals an intriguing connection between TET enzymatic activity, Vitamin C and IL-2/STAT5 signaling. "In mice that are deficient for components of IL-2/STAT5 signaling, such as IL-2, IL-2 receptors or STAT5, the Tregs cannot develop properly or they can have impaired function," Yue says. The researchers demonstrate that on one hand, TET-deficiency in Treg cells leads to impaired IL-2/STAT5 signaling; on the other hand, Vitamin C confers iTregs enhanced IL-2/STAT5 signaling by increasing the expression level of IL-2 receptor and the functional form of STAT5, and STAT5 binding to essential regions in the genome, rendering these cells survive better in tough environments with low IL-2 supplementation. "We are looking for more small molecules to stabilize TET activity and generate induced Tregs that are even more stable," says Yue. "These induced Tregs could eventually be used to treat patients." "This research gives us a new way to think about treating autoimmune diseases," says Samaniego-Castruita.       Resveratrol ameliorates high-fat-diet-induced abnormalities in liver glucose metabolism in mice via the AMPK pathway Hebei Medical Institute (China), July 19, 2021 A new study on high fat diet is now available. According to news originating from the Department of Internal Medicine by NewsRx correspondents, research stated, “Diabetes mellitus is highly prevalent worldwide.” Our news reporters obtained a quote from the research from Department of Internal Medicine: “High-fat-diet (HFD) consumption can lead to liver fat accumulation, impair hepatic glycometabolism, and cause insulin resistance and the development of diabetes. Resveratrol has been shown to improve the blood glucose concentration of diabetic mice, but its effect on the abnormal hepatic glycometabolism induced by HFD-feeding and the mechanism involved are unknown. In this study, we determined the effects of resveratrol on the insulin resistance of high-fat-diet-fed mice and a hepatocyte model by measuring serum biochemical indexes, key indicators of glycometabolism, glucose uptake, and glycogen synthesis in hepatocytes. We found that resveratrol treatment significantly ameliorated the HFD-induced abnormalities in glucose metabolism in mice, increased glucose absorption and glycogen synthesis, downregulated protein phosphatase 2A (PP2A) and activated Ca2+/CaM-dependent protein kinase kinase b (CaMKKb), and increased the phosphorylation of AMP-activated protein kinase (AMPK). In insulin-resistant HepG2 cells, the administration of a PP2A activator or CaMKKb inhibitor attenuated the effects of resveratrol, but the administration of an AMPK inhibitor abolished the effects of resveratrol. Resveratrol significantly ameliorates abnormalities in glycometabolism induced by HFD-feeding and increases glucose uptake and glycogen synthesis in hepatocytes.” According to the news editors, the research concluded: “These effects are mediated through the activation of AMPK by PP2A and CaMKKb.”     Hundreds of chemicals, many in consumer products, could increase breast cancer risk List includes potential carcinogens that act by stimulating production of hormones that fuel breast tumors Silent Spring Institute, July 22, 2021 Every day, people are exposed to a variety of synthetic chemicals through the products they use or the food they eat. For many of these chemicals, the health effects are unknown. Now a new study shows that several hundred common chemicals, including pesticides, ingredients in consumer products, food additives, and drinking water contaminants, could increase the risk of breast cancer by causing cells in breast tissue to produce more of the hormones estrogen or progesterone. "The connection between estrogen and progesterone and breast cancer is well established," says co-author Ruthann Rudel, a toxicologist and research director at Silent Spring Institute. "So, we should be extremely cautious about chemicals in products that increase levels of these hormones in the body." For instance, in 2002, when the Women's Health Initiative study found combination hormone replacement therapy to be associated with an increased risk of breast cancer, women stopped taking the drugs and incidence rates went down. "Not surprisingly, one of the most common therapies for treating breast cancer is a class of drugs called aromatase inhibitors that lower levels of estrogen in the body, depriving breast cancer cells of the hormones they need to grow," adds Rudel. To identify these chemical risk factors, Rudel and Silent Spring scientist Bethsaida Cardona combed through data on more than 2000 chemicals generated by the U.S. Environmental Protection Agency (EPA)'s ToxCast program. The goal of ToxCast is to improve the ability of scientists to predict whether a chemical will be harmful or not. The program uses automated chemical screening technologies to expose living cells to chemicals and then examine the different biological changes they cause. Reporting in the journal Environmental Health Perspectives, Rudel and Cardona identified 296 chemicals that were found to increase estradiol (a form of estrogen) or progesterone in cells in the laboratory. Seventy-one chemicals were found to increase levels of both hormones. The chemicals included ingredients in personal care products such as hair dye, chemical flame retardants in building materials and furnishings, and a number of pesticides. The researchers don't yet know how these chemicals are causing cells to produce more hormones. It could be the chemicals are acting as aromatase activators, for instance, which would lead to higher levels of estrogen, says Cardona. "What we do know is that women are exposed to multiple chemicals from multiple sources on a daily basis, and that these exposures add up." The Silent Spring researchers hope this study will be a wakeup call for regulators and manufacturers in how they test chemicals for safety. For instance, current safety tests in animals fail to look at changes in hormone levels in the animal's mammary glands in response to a chemical exposure. And, although high throughput testing in cells has been used to identify chemicals that activate the estrogen receptor, mimicking estrogen, the testing has not been used to identify chemicals that increase estrogen or progesterone synthesis. "This study shows that a number of chemicals currently in use have the ability to manipulate hormones known to adversely affect breast cancer risk," says Dr. Sue Fenton, associate editor for the study and an expert in mammary gland development at the National Institute of Environmental Health Sciences. "Especially concerning is the number of chemicals that alter progesterone, the potential bad actor in hormone replacement therapy. Chemicals that elevate progesterone levels in the breast should be minimized." The researchers outlined a number of recommendations in their study for improving chemical safety testing to help identify potential breast carcinogens before they end up in products, and suggest finding ways to reduce people's exposures, particularly during critical periods of development, such as during puberty or pregnancy when the breast undergoes important changes. The project is part of Silent Spring Institute's Safer Chemicals Program which is developing new cost-effective ways of screening chemicals for their effects on the breast. Knowledge generated by this effort will help government agencies regulate chemicals more effectively and assist companies in developing safer products.     Antioxidant activity of limonene counteracts neurotoxicity triggered by amyloid beta 1-42 oligomers in cortical neurons University of Naples (Italy), July 19, 2021 According to news reporting from Naples, Italy, by NewsRx journalists, research stated, “Many natural-derived compounds, including the essential oils from plants, are investigated to find new potential protective agents in several neurodegenerative disorders such as Alzheimer's disease (AD).” The news editors obtained a quote from the research from School of Medicine: “In the present study, we tested the neuroprotective effect of limonene, one of the main components of the genus * * Citrus* * , against the neurotoxicity elicited by Ab [ [1-42] ] oligomers, currently considered a triggering factor in AD. To this aim, we assessed the acetylcholinesterase activity by Ellman's colorimetric method, the mitochondrial dehydrogenase activity by MTT assay, the nuclear morphology by Hoechst 33258, the generation of reactive oxygen species (ROS) by DCFH-DA fluorescent dye, and the electrophysiological activity of K [ [V] ] 3.4 potassium channel subunits by patch-clamp electrophysiology. Interestingly, the monoterpene limonene showed a specific activity against acetylcholinesterase with an IC [ [50] ] almost comparable to that of galantamine, used as positive control. Moreover, at the concentration of 10 g/mL, limonene counteracted the increase of ROS production triggered by Ab [ [1-42] ] oligomers, thus preventing the upregulation of K [ [V] ] 3.4 activity. This, in turn, prevented cell death in primary cortical neurons, showing an interesting neuroprotective profile against Ab [ [1-42] ] -induced toxicity.” According to the news editors, the research concluded: “Collectively, the present results showed that the antioxidant properties of the main component of the genus * * Citrus* * , limonene, may be useful to prevent neuronal suffering induced by Ab [ [1-42] ] oligomers preventing the hyperactivity of K [ [V] ] 3.4.”     Meditation And Yoga Change Your DNA To Reverse Effects Of Stress, Study Shows Coventry University (UK), July 22, 2021 Many people participate in practices such as meditation and yoga because they help us relax. At least those are the immediate effects we feel. But much more is happening on a molecular level, reveal researchers out of Coventry University in England. Published in the journal Frontiers in Immunology, this new research examined 18 studies on mind-body interventions (MBIs). These include practices such as mindfulness meditation and yoga. Comprehensively, these studies encompassed 846 participants over 11 years. The new analysis reveals that MBIs result in molecular changes in the human body. Furthermore, researchers claim that these changes are beneficial to our mental and physical health. Body's Response to Stress Causes Damage To elaborate, consider the effect that stress has on the body. When we are under stress, the body increases the production of proteins that cause cell inflammation. This is the natural effect of the body's fight-or-flight response. It is widely believed that inflammation in the body leads to numerous illnesses, including cancer. Moreover, scientists also deduct that a persistent inflammation is more likely to cause psychiatric problems. Unfortunately, many people suffer from persistent stress, therefore they suffer from pro-inflammatory gene expression. But there is good news! According to this new analysis out of Coventry, people that practice MBIs such as meditation and yoga can reverse pro-inflammatory gene expression. This results in a reduced risk of inflammation-related diseases and mental conditions. Lead investigator Ivana Buric from Coventry University's Centre for Psychology, Behaviour and Achievement stated: Millions of people around the world already enjoy the health benefits of mind-body interventions like yoga or meditation, but what they perhaps don't realise is that these benefits begin at a molecular level and can change the way our genetic code goes about its business. These activities are leaving what we call a molecular signature in our cells, which reverses the effect that stress or anxiety would have on the body by changing how our genes are expressed. Put simply, MBIs cause the brain to steer our DNA processes along a path which improves our wellbeing. More needs to be done to understand these effects in greater depth, for example how they compare with other healthy interventions like exercise or nutrition. But this is an important foundation to build on to help future researchers explore the benefits of increasingly popular mind-body activities.               Large-scale study finds greater sedentary hours increases risk of obstructive sleep apnea Study finds that maintaining an active lifestyle can reduce the risk of OSA, encourages physicians to recommend exercise-based interventions for those at risk Brigham and Women's Hospital, July 22, 2021 A new study by investigators from Brigham and Women's Hospital examined the relationship between active lifestyles and the risk of obstructive sleep apnea (OSA). The study followed around 130,000 men and women in the United States over a follow-up period of 10-to-18 years and found that higher levels of physical activity and lower levels of sedentary behavior were associated with a lower risk of OSA. Their results are published in the European Respiratory Journal.  "In our study, higher levels of physical activity and fewer hours of TV watching, and sitting either at work or away from home were associated with lower OSA incidence after accounting for potential confounders," said Tianyi Huang, MSc, ScD, an Associate Epidemiologist at the Brigham. "Our results suggest that promoting an active lifestyle may have substantial benefits for both prevention and treatment of OSA."  OSA is a type of sleep apnea in which some muscles relax during sleep, causing an airflow blockage. Severe OSA increases the risk of various heart issues, including abnormal heart rhythms and heart failure.  Using the Nurses' Health Study (NHS), Nurses' Health Study II (NHSII) and Health Professionals Follow-Up Study (HPFS), the research team used statistical modeling to compare physical activity and sedentary hours with diagnoses of OSA. Both moderate and vigorous physical activity were examined separately and both were strongly correlated with lower risk of OSA, showing no appreciable differences in the intensity of activity. Moreover, stronger associations were found for women, adults over the age of 65 and those with a BMI greater than or equal to 25 kg/m2.  "Most prior observational studies on the associations of physical activity and sedentary behavior with OSA were cross-sectional, with incomplete exposure assessment and inadequate control for confounding," said Huang. "This is the first prospective study that simultaneously evaluates physical activity and sedentary behavior in relation to OSA risk."  This study also differs from others because of its large sample size and detailed assessment pf physical activity and sedentary behaviors. The research team was able to take many associated factors into account, making the findings more credible.  The authors note that all collected data, both of OSA diagnosis and physical activity or sedentary behavior, were self-reported. While all study participants were health professionals, mild OSA is often difficult to detect and can remain clinically unrecognized. Furthermore, only recreational physical activity was taken into consideration, leaving out any physical activity in occupational settings. Sedentary behavior was only counted as sitting while watching TV and sitting away from home or at work.  According to Huang, the next research steps would be to collect data using actigraphy, home sleep apnea tests and polysomnography, rather than self-reports.  In light of the findings, investigators encourage physicians to highlight the benefits of physical activity to lower OSA risk.  "We found that physical activity and sedentary behavior are independently associated with OSA risk," said Huang. "That is, for people who spend long hours sitting every day, increasing physical activity in their leisure time can equally lower OSA risk. Similarly, for those who are not able to participate in a lot of physical activity due to physical restrictions, reducing sedentary hours by standing or doing some mild activities could also lower OSA risk. However, those who can lower sedentary time and increase physical activity would have the lowest risk."

We've been on a round the world trip the last few weeks, talking about why investing beyond Australia's borders is a really good idea. Before we boarded the plane home, Alec and Bryce thought it would be good to hear from an expert. So we gave Emma Kirk from Magellan a call, and she agreed to come on the show and talk about how she started investing. Emma is a Key Account Manager - Listed Funds, for Magellan, an Australian fund manager with just shy of $100 billion in assets under management. With over 25 years experience in the financial services industry, Emma has worked at AMP, BT Financial Group and ANZ before Magellan. She talks about why it's a good idea to have a global focus as an investor, and what factors beginner investors should be considering, and then serves up the best analogy of the differences between LITs, LICs, Active ETFs and unlisted funds, with the use of a never-ending Tim Tam packet.Pre order the book on Booktopia or Amazon now. If you want to let Alec or Bryce know what you think of an episode, contact them here. Some of our favourite resources and offers to help you during your journey:$50-$200 OFF some amazing investing courses by our friend-of-the-show, OwenTrack your investment portfolio with Sharesight.Get a free stock when you sign-up to Stake, using the code EQUITYMATESGet exclusive access to our favourite data and insights platform, TIKRTake the emotion out of investing in Bitcoin, Ethereum, Gold and Silver with micro-investing app, Bamboo. Use EQUITY MATES for $10 when you sign-upGet $15 of Bitcoin, using one of our favourite crypto-currency exchanges, SwyftxGet 5 free trades if you plan to use the broker SelfWealth Make sure you don't miss anything Equity Mates related by signing up to our email list. And visit this page if you love everything Equity Mates and want to support our work.*****Any views expressed by the podcast host or any guest are their own and do not represent the views of Equity Mates Media or any other employer or associated organisation.Always remember, all information contained in this podcast is for education and entertainment purposes only. It is not intended as a substitute for professional financial, legal or tax advice. The hosts of Equity Mates... See acast.com/privacy for privacy and opt-out information.

This week on the Sociall.in social media and digital marketing podcast (recorded at our home-office in Chennai) we're talking about Google's AMP woes, Facebook's Cloud gaming PWA and WhatsApp on multiple devices.

Coffee and Conversations w/LaKisha A Part of God's Well Thought Out Plan! I Don't Own the Rights To This, Music it is for entertainment purposes only. It is according to the fair use act. Scripture Reference: John 1 AMP; Isaiah 9:6; Genesis 1:1; John 10:10; 1 Corinthians 2:14; Romans 8:28; Philippians 1:6; Ephesians 3:20-21; Philippians 4:19; Philippians 3:14; Joyce Meyer Confessions Deuteronomy 28:1-6; Galatians 5:7; Joyce Meyer Confessions For daily devotionals: https://www.lakishamjohnson.com/devotionals Our podcast are now available! http://anchor.fm/justbeinglmj For exclusive content, inspiration, and past favorites: https://www.youtube.com/channel/UCXQpH5fkmiYgipbtKi7Wukw Thank you for your continued support of the ministry! 1. PayPal.me/justbeinglmj 2. Cash App-$lmjministry (please put your email in the for line) 3. Mail-PO Box 4186, Little Rock, AR 72214 4. Donate online-https://www.lakishamjohnson www.lakishamjohnson.com #1074 --- Support this podcast: https://anchor.fm/justbeinglmj/support

Need some practical tips on how to apply Prov. 22:6? Listen in to this episode! “Train up a child in the way he should go [teaching him to seek God's wisdom and will for his abilities and talents], Even when he is old he will not depart from it.” ‭‭Proverbs‬ ‭22:6‬ ‭AMP‬‬ https://www.bible.com/1588/pro.22.6.amp Listen to this episode and let's discuss on Clubhouse this Tuesday. Don't forget to screenshot this episode and share to your IG stories! Tag @iamdanielleavery once you do! WE NEED EACH OTHER! Leave a rating & review! ❤️ Follow me on IG and Twitter: IG @iamdanielleavery Instagram.com/iamdanielleavery Twitter @VBGPodcast #christianwomen #christianmillenial Questions/Comments?? Email me at ValidatedByGodPodcast@gmail.com --- This episode is sponsored by · Anchor: The easiest way to make a podcast. https://anchor.fm/app Support this podcast: https://anchor.fm/ValidatedByGod/support

¿Qué es AMP para emails? ¿Es posible cerrar ventas sin tener que salir de tu email? ¿Qué ventajas e inconvenientes tiene este sistema? Siempre que hacemos email marketing nos marcamos el mismo objetivo: que lo abran, hagan clic en nuestro correo, vayan a nuestra web y que el suscriptor realice la acción que deseamos.  El “problema” es que esta última interacción se produce siempre fuera del email.  A la pregunta de: ¿y no es posible hacer ventas o cerrar esas interacciones finales dentro del email?La respuesta es: sí.  Hay una herramienta que te permite realizar cualquier acción y cualquier conversión desde el correo electrónico sin depender de herramientas de terceros.  Es AMP para emails y de ella te lo cuento todo en este nuevo episodio.  ¿Qué vamos a ver en este episodio?  Este nuevo episodio de Tienes un Email tiene un objetivo por encima de todos: que aprendas cómo sacarle provecho a AMP para emails. Y, para ello, hago un recorrido extenso sobre qué es esta herramienta, qué ventajas e inconvenientes tiene su uso dentro de tu negocio online y qué elementos pueden ayudarte a hacer campañas y correos electrónicos TOP. Para descubrirlo todo, dale al play y te espero al otro lado. Momentos destacados en el episodio [ 3:15 ] Definición tradicional de AMP “a lo Paco Vargas”.[ 4:40 ] Las enormes ventajas del uso de AMP para emails.[ 7:24 ] Los elementos más TOP de AMP.[ 9:37 ] Inconvenientes o la otra cara de la moneda de AMP para emails. PARA LA GENTE QUE SABE QUE EL DINERO ESTÁ EN LA LISTA ¿Te gustaría empezar a construir y monetizar tu lista de suscriptores? Pásate por pacovargas.es/empieza y entra a mi masterclass gratuita Tu Email Marketing Mínimo viable. Con esta masterclass aprenderás: Qué escribir en tus emails.Mi estrategia PRO para pasar de suscriptor a cliente desde el primer email.Cómo hacer que tus suscriptores abran y cliquen tus emails.Todo esto, sin gastar ni un euro en publicidad, sin miles de suscriptores y sin saber de tecnología. Además, recibirás un consejo diario sobre Email Marketing. Cada día. En tu bandeja de entrada. Listo para implementar. pacovargas.es/empieza Quiero la masterclass Toca valorar pros y contras y decidir si AMP es la herramienta que necesitas  Conseguir conversiones dentro de nuestros propios correos electrónico tiene sus ventajas e inconvenientes, pero está claro que podemos hacerlo sin depender de otras herramientas externas. Ahora ¿te interesa? ¿No?Esa ya es tu elección. Si te lanzas a utilizarla, me encantaría saber cuál es tu experiencia. Cuéntame en comentario y soy “todo ojos”.

Playing music for you to relax and enjoy while you take a break! Pardon Our Podcast. (POD) We are Amp! --- Support this podcast: https://anchor.fm/nexxt-set-amp/support

This week: Clubhouse is open, AMP is going away, and WordPress is stepping up. Listen in to this episode to hear what happened this week in digital marketing.

Coffee and Conversations w/LaKisha I EXPECT God to Answer! I Don't Own the Rights To This, Music it is for entertainment purposes only. It is according to the fair use act. Scripture Reference: John 1 AMP; Isaiah 9:6; Genesis 1:1; John 10:10; 1 Corinthians 2:14; Romans 8:28; Philippians 1:6; Ephesians 3:20-21; Philippians 4:19; Philippians 3:14; Joyce Meyer Confessions Deuteronomy 28:1-6; Galatians 5:7; Joyce Meyer Confessions For daily devotionals: https://www.lakishamjohnson.com/devotionals Our podcast are now available! http://anchor.fm/justbeinglmj For exclusive content, inspiration, and past favorites: https://www.youtube.com/channel/UCXQpH5fkmiYgipbtKi7Wukw Thank you for your continued support of the ministry! 1. PayPal.me/justbeinglmj 2. Cash App-$lmjministry (please put your email in the for line) 3. Mail-PO Box 4186, Little Rock, AR 72214 4. Donate online-https://www.lakishamjohnson www.lakishamjohnson.com #1075 --- Support this podcast: https://anchor.fm/justbeinglmj/support

What does it take to get on the test launch schedule at Vandenberg Air Force Base? How do so many organizations unnecessarily delay their time because of unexpected but avoidable issues? Edmund Burke of Space Information Labs joins host Jason Kanigan on the Cold Star Project to explain range safety compliance - happenings, trends, success, and failure. We discuss: The shift to Autonomous Flight Termination and Space Based Range Brief explanation of flight termination systems Advantages and necessity of intelligent lithium battery systems RadTol BMS, and radiation tolerant avionics Testing and documentation required to fly (RCC 319-19) A decade of watching companies fall short on promises because the didn't understand what it takes Danger of vertical integration for startups Important lessons learned Edmund Burke served as an Air Force Program Manager and Project Director for many years prior to founding Space Information Laboratories in 2004. He served as the Space Lift Range System, Range Instrumentation and Metric Track lead for both Vandenberg AFB and Cape Canaveral, FL. Mr. Burke is a master designer, inventor and business development leader of launch vehicle, missile and small satellite avionics and power system technologies that are required to be Range Safety and Space environmentally qualified. He holds four USPTO utility patents on SIL's VBITS GPS Tracking and AFTS, VBIRS – Space Based Range, Li-Ion Polymer Intelli-Pack® Battery, Intelli-Avionics® and Chameleon 12U to 27U Open Modular Scalable Reconfigurable Bus technologies. Mr. Burke has a Bachelors of Science in Electrical Engineering from Virginia Tech and a M.S. in Astronautical Engineering from West Coast University. Useful Links: Still image of SIL flight termination module: https://coldstarproject.com/edmundburkesilftcphoto Still image of SIL 2 Amp battery unit and battery management system (BMS): https://coldstarproject.com/edmundburkesilbmsphoto Space Information Labs website: https://www.spaceinformationlabs.com/ Disclaimer: We were not remunerated in any way by Edmund Burke or Space Information Laboratories for this discussion. OpEx Society: https://www.opexsociety.org Get new episodes directly in your inbox: https://www.coldstartech.com/msb Talk to Cold Star: https://www.coldstartech.com/bookcall

Charlie Eisenhood and Keith Raynor chat about the Boston Invite and the impressive performances from AMP, Brute Squad, and Dig. They also discuss Masters Nationals before taking a look at the top 10 teams in the Power Rankings and sharing some thoughts. Later, they break down week 7 in the AUDL and make their picks for the upcoming weekend.

Playing music for you to enjoy. And, giving information you can use in your daily lives. We are AMP! --- Support this podcast: https://anchor.fm/nexxt-set-amp/support

Google's new update hit in May, Core Web Vitals or Page Experience. This update focuses more on technical aspects of the site than content. However, at the same time, Google discontinued AMP, in which publishers had to invest heavily to maintain their presence in the search results. These changes will strain the Google-publisher relationship even further. Even more, because of the technical nature of the update, many businesses are simply unable to do much to accommodate this. Either legacy code that can't be changed or 3rd party Content Management Systems that all have their own nuances, it is mainly on them to accommodate this update.  But is Google's influence waning? Many signs point to an industry that is tired of being forced to react to Google's decisions and whims. Learn more about your ad choices. Visit megaphone.fm/adchoices

Welcome to the 74th episode of the Truth About Vintage Amps Podcast, the bi-weekly show where amp tech Skip Simmons answers all of your pressing guitar amplifier questions. No topic is too basic... or seemingly too complex! This week's episode is sponsored by Amplified Parts and Grez Guitars.  Some of the topics discussed this week:  5:53 Old typewriters, again ('The Typewriter Revolution,' thanks Doug F!); a Canon amplifier from Australia; Monkey Shoulder Scotch Whisky 9:35 Bitcoin mining, explained    12:44 Recommended reading: 'The Birth of Loud' and testing amps with full volume    15:40 Recommended reading: 'The Unidentified' by Colin Dickey; Bitcoin as casino chips; a DIY trem?    20:56 Bitcoin mining, again; powering a tube amp with a battery/generator; a 15" speaker cabinet for a Masco MA-17   29:39 Sierra Nevada's Summer Break beer    30:35 Using a Fender's second input for speaker-driven reverb   33:36 Best uses for a Masco EMM-6 pre-amp mixer     37:03 B+ on listener Geoff's tamed Fender Twin   41:20 Can you source amp hum just from hearing it?    45:35 Building a Princeton clone with not-quite-exact capacitors; cleaning pots     56:56 Skip is angry; 'Sessions with Sinatra'    1:06:13 Fixing the reverb on a Gibson Falcon; Bobby Charles; the California Honeydrops; Eddie Hinton   1:13:46 John Fogerty replies Co-hosted by the Fretboard Journal's Jason Verlinde. Email or send us a voice memo to: podcast@fretboardjournal.com or leave us a voicemail or text at 509-557-0848. And don't forget to share the show with friends.   

"What matters is not how we define God but how God defines us. God asks that we do what he, or she, or they, tell us to do with our lives and our gifts no matter which worldly societies believe we are less-than, believe we shouldn't speak, believe we are not worth listening to. [...] What matters is hewing to what God demands of us..." Summer Witness: Katharine Jager-Rubinson, Associate Professor of English, University of Houston PDF of Message Slides Scripture Readings (NIV, AMP, The Message) Galatians 3:28 NIV Galatians 3:28 AMP Galatians 3:28 MSG Hymn: Spirit of The Living God (Lyrics) Text and Music: Daniel Iverson Message Transcript Facebook: https://www.facebook.com/HoustonMennonite Website: https://houstonmennonite.org

The highly acclaimed and respected Dr Shane Oliver is living a life of noble purpose, and he shares how you can too. Shane was attracted to join AMP as an economist way back in the early 1980s on the strength of their stated noble purpose - Amicus certus, which is latin for ‘a sure friend in uncertain times'. And this is exactly what Shane has proved to be over the decades, where he has remained at AMP and risen to the highest ranks as their Head of Investment Strategy and Economics and their Chief Economist. He embodies this noble purpose and his constant enduring loyalty, humility, patience, persistence and reliability underpin the quality of his independent, objective and transparent insights and forecasts on the global economy and its impacts on all investment asset classes. I've been listening to Shane's words of wisdom for decades now and they have always proved to be informative, accurate, and mostly on the money. You will struggle to find an economist and investor who adopts a consistently independent and objective view, so he is always worth listening to and I'm very humbled and honoured to have him on the show.     Shane is one of Australia's longest running top economic and investment experts. His extensive experience in analysing economic and investment cycles, and understanding of what current positioning means for the return potential for different asset classes across shares, bonds, property and infrastructure is second to none. Shane is a regular media commentator on economic and investment market issues and engages regularly with investors at public events and forums.  He's responsible for the provision of economic and macro investment analysis and, as part of the broader Investment Strategy and Dynamic Markets Team, the management of the Dynamic Markets Fund and the determination of AMP Capital's asset allocation policy which is applied across more than $50bn invested in multi-asset funds. So if you're looking to understand whats happening and what is likely to happen in our uncertain world and how this affects your investments, you are going to love this informative discussion where Shane talks about: How he helps make you a better investor The wall of worry and its impact His definition of economics, including positive versus normative economics, and its importance to your decision making The four types of assets, his view on crypto currencies  and what lies ahead in each asset class across equities and property in our post pandemic world Why downturns are so hard to predict The investment wisdom of Don Stammer, Jack Bogel and other investment greats A great overview of the economic and investment movements over the last 40 years as a context for what is happening now, what is likely to happen, and what you can and need to be doing about it And if, like me, you enjoy Shane's insights today, make sure you follow him on Twitter at @shaneoliver, where he regularly updates you with Oliver's Insights along with his weekly reports. And if you want some assistance in defining your noble purpose, grab a copy of my book The Freedom Formula by jumping on https://bushymartin.com.au/books/, where I devote a couple of chapters to giving you a step by step process to imagine and define your why and your life vision. Shane will tell you that there's still lots of opportunities ahead for property investors in Australia. And if you want to know how to get started in property investment, or how to make your property investments work a lot better, I invite you to join me on our unique live interactive KnowHow Property Freedom Flight program, where I'll personally guide you through my proven process for property investment success.  To book your ticket or find out more, just click on https://knowhowproperty.com.au/freedom-fighters. Shane's book recommendation: Money Is Panics And Crashes by Charles Kindleberger Get Invested is the leading weekly podcast for Australians who want to learn how to unlock their full ‘self, health and wealth' potential. Hosted by Bushy Martin, an award winning property investor, founder, author and media commentator who is recognised as one of Australia's most trusted experts in property, investment and lifestyle, Get Invested reveals the secrets of the high performers who invest for success in every aspect of their lives and the world around them. Remember to subscribe on your favourite podcast player, and if you're enjoying the show please leave us a review. Find out more about Get Invested here https://bushymartin.com.au/get-invested-podcast/  Want to connect with Bushy? Get in touch here https://bushymartin.com.au/contact/  This show is produced by Apiro Media - http://apiropodcasts.com

This month on Episode 26 of Discover CircRes, host Cindy St. Hilaire highlights four original research articles featured in the June 25th and July 9th issues of Circulation Research. This episode also features an in-depth conversation with Dr Hirofumi Watanabe, Dr Ariel Gomez, and Dr Maria Luisa Sequeira-Lopez from the University of Virginia about their study, The Renin Cell Baroreceptor, A Nuclear Mechanotransducer Central for Homeostasis.   Article highlights:   Mesirca, et al. Electrical Remodeling of the AV Node in Athletes   Yang, et al. Macrophage-Mediated Inflammation in COVID-19 Heart   Örd, et al. Functional Fine-Mapping of CAD/MI GWAS Variants   Akhter, et al. EC-S1PR1 Activity Directs Vascular Repair     Cindy St. Hilaire:        Hi and welcome to Discover CircRes, the podcast of the American Heart Association's Journal, Circulation Research. I'm your host, Dr Cindy St. Hilaire from the Vascular Medicine Institute at the University of Pittsburgh, and today I'll be highlighting the articles presented in our June 25th and July 9th issues of Circulation Research. I'm also going to speak with Dr Hirofumi Watanabe, Dr Ariel Gomez and Dr Maria Luisa Sequeira-Lopez from the University of Virginia about their study, The Renin Cell Baroreceptor, A Nuclear Mechanotransducer Central for Homeostasis. Cindy St. Hilaire:        The first article I want to share comes from the June 25th issue of Circ Res and is titled Intrinsic Electrical Remodeling Underlies Atrial Ventricular Block in Athletes. The first authors are Pietro Mesirca, Shu Nakao, Sarah Dalgas Nissen, and the corresponding author is Alicia D'Souza. And they're from the University of Manchester in the UK. Cindy St. Hilaire:        Endurance training has cardiovascular benefits, but when taken to extremes, it can elicit heart problems such as atrial ventricular block or AV block. AV block is the impaired conduction through the AV node. In fact, some endurance athletes require pacemakers later in life due to AV block. One hypothesis for this conundrum is that the problem stems from disruptions in the autonomic nervous system. This study shows that in fact, the intrinsic electrophysiology of the heart is to blame. They used trained race horses, as well as mice, subjected to endurance swimming as models for human endurance athletes. Electrocardiograms on the animals showed that just like human athletes, the race horses and the swim-trained mice exhibited signs of AV node dysfunction that is not seen in sedentary controls. Cindy St. Hilaire:        Because the dysfunction also persisted when the autonomic nervous system was blocked, the team examined molecular changes within the heart itself. They found that ion channels, HCN4 and Cav1.2, were less abundant in the AV nodes of trained animals than those of the controls. The team went on to identify two microRNAs regulating HCN4 and Cav1.2 production and showed that suppression of these microRNAs restored normal heart electrophysiology in the mice. If the result holds true for humans, this could pave the way for novel treatments for AV block. Cindy St. Hilaire:        The second article I want to share is titled An Immuno-Cardiac Model for Macrophage-Mediated Inflammation in COVID-19 Hearts. The first authors are Liuliu Yang, Yuling Han, Fabrice Jafre, Benjamin Nilson-Payant and Yaron Bram. And the corresponding author is Shuibing Chen. And they're from Cornell University Medical Center. Cindy St. Hilaire:        COVID-19 is primarily a respiratory disease, but cardiac complications are common and appear to be linked with worsening outcomes. Post-mortem examinations of COVID-19 patients' hearts have revealed abnormally high numbers of macrophages, suggesting that these cells have a role in the heart pathology. To investigate this possibility, this group co-cultured macrophages and cardiomyocytes, both which were derived from human induced pluripotent stem cells and infected the cultures with SARS-CoV-2 virus. Upon infection, both cell types increased their rates of apoptosis. However, the number of cardiomyocytes succumbing to the cell death process was far higher than that of macrophages. When cardiomyocytes were infected with the virus in the absence of macrophages, their rate of apoptosis dropped. Cindy St. Hilaire:        The team showed that macrophages produced large amounts of the inflammatory cytokines, IL-6 and TNF, in response to the virus and that trading the cardiomyocytes directly with the cytokines could similarly induce apoptosis. Blocking IL-6 and TNF alpha signaling prevented the macrophage-driven cardiomyocyte death. The team then identified two FDA approved drugs, ranolazine and tofacitinib, that prevented the virus-induced cardiomyocyte death in vitro and suggest that these drugs now be investigated in larger animal models. Cindy St. Hilaire:        The next article I want to share is titled Single-Cell Epigenomics and Functional Fine-Mapping of Atherosclerosis GWAS Loci. The first author is Tiit Ord, and the corresponding author is Minna Kaikkonen, from the University of Eastern Finland. Cindy St. Hilaire:        Genome-wide association studies, or GWAS studies, have identified hundreds of genetic loci associated with coronary artery disease and myocardial infarction. And many of these genes likely play a role in atherosclerotic development. However, most of these loci are located in non-coding intergenic regions of the genome. Thus, their functional effects on atherosclerosis development are not clear. Non-coding regions of the genome may contain gene regulatory elements, including cell type specific enhancers. And because such enhancer elements often have open chromatin structures, this team profiled the chromatin accessibility of single cells in human atherosclerotic plaques. Cindy St. Hilaire:        They found that many cell type-specific assessable regions overlapped with both transcription factor binding motifs, as well as GWAS-identified coronary artery disease loci. Using an algorithm called Cicero, the team was able to predict likely genes under the control of these accessible intergenic regions. They found that in more than 30 cases, they were able to confirm these intergenic regions control gene expression in in vitro assays. This work highlights the power of chromatin accessibility mapping for homing in on GWAS loci with transcriptional effects, and for identifying the likely genes they regulate. Cindy St. Hilaire:        The last article I want to share is titled Programming to S1PR1+ Endothelial Cells Promote Restoration of Vascular Integrity. The first author is Mohammed Zahid Akhter, and the corresponding author is Dolly Mehta, and they're from the University of Illinois College of Medicine. Cindy St. Hilaire:        Endothelial cells line the lumen of our blood vessels, forming a barrier that regulates the transport of nutrients, fluids and circulating cells to and from tissues. The lipid signaling molecule, sphingosine-1-phosphate, or S1P, and its receptor, S1PR1, promote endothelial barrier integrity. But how S1P and S1PR1 signaling might restore barrier function to inflammation-induced leaky vessels is unclear. Cindy St. Hilaire:        Using mice with fluorescently tagged S1PR1, this group showed that when mice are given a dose of the bacterial endotoxin, LPS, which induces lung inflammation, there's a dramatic boost in the proportion of growing lung endothelial cells. This boost in S1PR1+ endothelial cells is due to their increase in proliferation. Cindy St. Hilaire:        The authors go on to show that this proliferation is accompanied by increased production of the transcription factors involved in S1P synthesis and secretion. When they transplanted S1PR1+ cells into mice whose endothelial cells lacked the receptor, they could rescue the leaky blood vessels. By detailing the cells and molecular players responsible for vessel recovery after inflammation, this work may inform repair boosting therapies for chronic inflammatory conditions. Cindy St. Hilaire:        So today with me, I have Dr Hirofumi Watanabe, Dr Ariel Gomez and Dr Maria Luisa Sequeira-Lopez, from the University of Virginia. And they are all with me to discuss their study, The Renin Cell Baroreceptor, a Nuclear Mechanotransducer Central for Homeostasis. And this article is in our July 9th issue of Circulation Research. So thank you all for joining me today. I think we're spanning 13 time zones, so I appreciate you all making the effort. Maria Luisa Sequeira-Lopez:  It's our pleasure. Thank you. Ariel Gomez:               Thank you. Hirofumi Watanabe:   Thank you. Cindy St. Hilaire:        I won't lie, the Renin-Angiotensin-Aldosterone System is quite complex, so we're not going to try to break it all down here, but it is essential for the regulation of fluid balance and blood pressure in the body. Without it, things go quite awry. And your study is focusing on the kidney cell that produces renin in response to the minute changes in the blood pressure and the composition and the volume of the extracellular fluid in the body. So I'm wondering if, before we jump into the study, if you can give us a bit of background about these renin-producing cells and what is known about the renal pressure sensing system? Maria Luisa Sequeira-Lopez:  So in the adult mammalian kidney, renin cells are located at the tip of the afferent arterioles at the entrance to the glomeruli. So that's why they are called juxtaglomerular cells. They synthesize and release renin. This is then, as you mentioned, the rate-limiting enzyme for the renin-angiotensin system that controls blood pressure and fluid-electrolyte homeostasis. However, during early embryonic development, as demonstrated many years ago, renin cells are widely distributed along the renal arterial tree and inside the glomerulus and the interstitium. And with maturation they differentiated to vascular smooth muscle cells and they end up being located in the juxtaglomerular area. Maria Luisa Sequeira-Lopez:  But in response to a homeostatic challenge, such as hypertension, dehydration, hemorrhage, there is an increase in the number of renin-expressing cells along the renal arterial tree, resembling the embryonic counter. And this occurs mostly by re-expression of renin from vascular smooth muscle cells that descended from originally renin-expressing cells. And when the challenge passes, then they stop expressing renin and become vascular smooth muscle cells again. So renin cells are extremely plastic and they can switch back and forth from an endocrine to a contractile phenotype.   Cindy St. Hilaire:        I'm really glad you mentioned the vascular smooth muscle cell angle because I actually have a question about that later on. But before I get to that question, one of the things that I love reading in studies is when a current paper references much older work that often has a really intricate or insightful observation. And in your paper you cited, I believe it was in 1957, was the first real hypothesis that there is an existence of this pressure sensing mechanism in the kidney, what we're calling this baroreceptor. Yet, that was a long time ago and the identity has really been elusive. So I was wondering why has it just been so difficult to really pin down this baroreceptor and how this pressure and fluid sensing works in these cells? Ariel Gomez:               So it was elusive, as you said. The reason is the researchers didn't have the tools to actually study it. It really requires an evolution, conceptual evolution, and scientific evolution, as well as technical development. And so we were fortunate over time, over the years. We developed ways to mark the cells endogenously with the appropriate fluorescent markers, genetically engineer, then develop models that allowed to drop the blood pressure in a consistent manner, and so forth. And we could follow the lineage of these cells and study them as they move back and forth from their phenotypes. So I think it was a matter of even Dr Tovian, who is the person that you mentioned, Lou Tovian, who I actually met a long time ago. So he even postulated that maybe it was a stretch mechanism, and that's one of the great contributions of Hirofumi who figure out how to stretch the cells using different ways of doing that. Cindy St. Hilaire:        So in your quest to identify this baroreceptor, you use several murine models. A surgical tool, but also several genetic tools. And I was wondering if you could share a little bit about that initial surgical model, that aortic constriction and maybe the pros and cons about that method? Hirofumi Watanabe:   And so we established surgical model of in mice. We created inductation between the roots of the right and left renal arteries. By the surgery, and our right kidney receives high pathogen pressure, and the left kidney receives low pathogen pressure. And this surgery model resulted in a marked difference in the expression of renin in each kidney. And by RT2 PCR and in situ hybridization, renin was decreased in the right kidneys and increased in the left kidneys. Cindy St. Hilaire:        Excellent. So it's a really powerful model because you can use the same mouse to look at the same... Ariel Gomez:               Right. So the beauty of that is that, Hirofumi, by doing that, he got rid of any genetic variation between the mice. Because you are doing the high and low pressure in the same mouse. Maria Luisa Sequeira-Lopez:  And another question I can think that we have said was when, if you calculate the number of cells that increase in one kidney and decreases in the other one, if you add them, it ends up being the number of cells in a non-aortic coarctation mouse. So it looks like- Cindy St. Hilaire:         It's a literal seesaw. That's beautiful. At least the math works out in your favor in the end. That's great. Maria Luisa Sequeira-Lopez:  And that's something that Luis Tovian didn't see, because what he did is he increased the perfusion pressure in an isolated kidney and what he observed was less granulation. So it was an indirect method to find less renin in those kidneys. But with a low pressure, he didn't observe an increase in renin, or increase in granulation. What we know that really happens. Cindy St. Hilaire:        So you mentioned smooth muscle cells in the beginning of our discussion and my training has been in smooth muscle cells, vascular smooth muscle cells, mostly though focused on the aorta, especially in mice. A lot of times we just say smooth muscle cells, but people are really talking about the aortic smooth muscle cells in the mice. And in humans, in the coronaries. But we use the mouse aortic smooth muscle cells as the model, which you can obviously see when you frame it out like that, some issues. And one of the things we talk about at least in athero is the cell plasticity and this phenotype switching from the contractile quiescent state to one that's associated with disease processes. Cindy St. Hilaire:        And we've really evolved on what we've known about that. It used to be just about the migration and proliferation. Now it's about the actual phenotypic switching into different kinds of cells. Macrophage-like cells, for one. And yours really was the first to bring to my eyes that there's probably many more regarding that. So could you maybe expand a little bit on these renal smooth muscle cells or renin-like cells maybe, and what's happening in that disease process? And do we know the point at which it can switch and make renin and go back versus switches and doesn't return? Is that part of the disease process? Ariel Gomez:               We describe the plasticity of the smooth muscle cells from the renal arterioles long time ago. I mean, I think, I would say that even at the beginning of my career. And at that time people didn't use that term so much, plasticity. We didn't know how to call it because it was a switch back and forth from a smooth muscle contractile phenotype to endocrine without, at the moment, without causing disease. And the cells were able to come back to be smooth muscle cells. But the period of the stimulation was only a week or so. So during that time, the cells can go back and forth. And now we know that they do that. But if you create a persistent stimulation, and this is another paper that we are working with Hirofumi and Maria Luisa, if you create a knockout renin or knockout of angiotensin receptors or so forth, the stimulation doesn't stop because there is no angiotensin. Ariel Gomez:               And so under those conditions, the cells reach a point in which they become very aggressive, almost embryonic-like. They are constantly stimulated. They are attempting to reestablish the phenotype and in doing so, they create these concentric vascular hypertrophy. And I don't know whether we are going to send the paper to Circulation Research or to where, but we are still writing it. After that, we don't know whether they can come back because they are so seriously sick. And we know that they are responsible for this, but this is another paper. Maria Luisa Sequeira-Lopez:  Another thing that I wanted to add is that these cells have been extremely difficult to study. Ariel has been developing many, many tools that allow him to dissect them and cover many secrets of the cells. But if you... First because they are very, very few in the kidney. And there were no markers to isolate them. And if you put them in culture, now that we can have them live with a person marker, they stop expressing renin and making renin within 24-48 hours. So it's difficult to study. So that's why Hirofumi [inaudible 00:19:21] how the system works. Stimulating them with cyclic AMP, they go back like renin. If not, they differentiate into vascular smooth muscle cells. It looks like that's their default pathway. So they need to sense that there is a need for renin to increase the blood pressure and electrolyte homeostasis. So that's one of the characteristics of the cells. But if you stimulate constantly, as Ariel said, then they may be hard to… They cannot come back. Cindy St. Hilaire:        It's over the tipping point a bit. Maria Luisa Sequeira-Lopez:  Yes. Cindy St. Hilaire:        In your discussion you mentioned another study from your group that kind of took more of a developmental angle. And you mentioned that you had identified unique chromatin structures of renin-producing cells, and you also identified what are called super enhancers that help dictate the differentiation of these running progenitor cells into renin producing cells. And then in your mechanical stimuli experiments, you mentioned identifying similar chromatin signatures. And I was wondering what this might suggest in regards to the disease pathogenesis. And I guess I'm thinking about it in terms of in many diseased states, we see this activation of developmental programs that either are not stopped or just go on and are even higher expressed than in developmental programs. And is that you think is happening in these renin cells? A developmental program gone awry? Ariel Gomez:               Yeah, definitely. I definitely think so. I think we all, the three of us think that way. Yeah. I think it's an exaggeration of a developmental program. One thing that we didn't mention and why the vessels get so sick is because during development, these cells contribute to the formation of the vasculature. And so when they regress so much trying to make renin... And they make it. I mean, they go from 20,000 units to 2 million of renin, right? And they never stop. But when they regress so much, they regressed on embryonic stage and they think that they need to make more blood vessels to actually increase the flow and the oxygenation of the tissue. But in doing so, they create more pathology. So maybe, Hirofumi, I don't know if you're going to ask him, but one of those super enhancers is the Lamin A/C gene. And he has studied that in this Circulation Research paper that we are talking about. Maria Luisa Sequeira-Lopez:  I just wanted to add that they also make lots of angiogenic factors to make the vessels. Cindy St. Hilaire:        Got it. So developmentally, they're activating more production of renin but they're also producing these pro angiogenic cytokines and really driving that… Ariel Gomez:               BGF. They produce a type of BGF or angiopoietins. Cindy St. Hilaire:        Interesting. Ariel Gomez:               Yeah. And things like that. Cindy St. Hilaire:        I really liked reading about this magnetic bead experiment that you used as the mechanical stimuli. Frankly, I saw the picture and I brought it to my lab and said, "Guys, figure out how to do this." Can you explain a little bit about it? It seemed really nice, really elegant and very tuneable. So I'm excited. I'm sure many more people are excited to hear about it. Hirofumi Watanabe:   So we applied coated magnetic beads to the cultured ring cells. Then we placed a magnet above the cells so we can pull the cells by magnetic force. Cindy St. Hilaire:        How strong is the magnet that it doesn't just rip everything up? Hirofumi Watanabe:   Yeah. We cannot observe the shapes of the cells, but yeah, I hope it's just stretch. Cindy St. Hilaire:        Yeah. Well, it certainly elicited an effect. So, in terms of future translational potential, what do you think about these findings that suggest either potential future therapies or even targets that we can use to develop therapies? Is there a future therapeutic angle to these really interesting biomechanical findings? Ariel Gomez:               Discovering or knowing the structure of these pressure sensing mechanism, I think we'll eventually have many applications because it will be applicable to hypertension, of course. And maybe we can begin to think... Not yet because it's really a fundamental discovery, it's not yet at that stage. But eventually the information can be used to start thinking about treatments that are addressing those particular structures that are involved from the beta one, integrating all the way to the nucleus. And little by little people started developing epigenetic therapies, right? And we are testing some of these compounds in our lower authority. Not with this model, with other models. But I think eventually we will be able to do what was the dream. It was really a dream years ago, was to do molecular therapy, right? And so a small compound development will play an important role. And eventually driving the molecules to the exact place in the genome is... So it would be not only patient-oriented, personalized medicine, but local specific. That should be the goal of medicine in the future. I won't be there when we get there. Cindy St. Hilaire:        I don't know. CRISPR is moving things rather fast, so that's great. Ariel Gomez:               Oh, yeah. You're right. You're right. You're right about that. Okay. Cindy St. Hilaire:        So what's next in this project? What do you think is the next low hanging fruit? Now that you've identified this baroreceptor or maybe a component of a larger baroreceptor family, what do you think is the next most important question? Maria Luisa Sequeira-Lopez:  We want to know what is in-between. And the bigger one integrating and the Lamin A/C. And also, we want to see how fast this reacts. So we'll be doing experiments with the constriction for just a few hours, and harvest both kidneys and we will try to do single cell RNA-seq and a from those vials. Hirofumi Watanabe:   I think we want to study how Lamin A/C regulates renin expression in renin cells, so chromatic modification initiated by changes in particle pressure more. Ariel Gomez:               And I think the... What I've been now pushing a little bit is to remember that there is another cell in there that is in between the pressure and the JG cells. And that is the endothelium cell. Right? And so, they are communicating with one another. So we are going to engage some... In fact, it's already happening. A member of the lab is already working with the same model that Hirofumi used, looking at endothelial cells label also using aninterfering promoter linked to a fluorescent protein. So we want to know what happens to the endothelial cells, because they are receiving the brunt of the pressure. And we don't know how they sense. We described the mechanosensing capability of the JG cells, the renin cells, but the whole system is probably a lot more complex than what we think. Cindy St. Hilaire:        I think that's the lesson of renin angiotensin signaling. It's always more complex. Ariel Gomez:               Yeah. Exactly. Cindy St. Hilaire:        Well, thank you all so much for joining me today. This is a beautiful study, very elegant. And I liked the new kind of in vitro models with this bead system. And congratulations on a whole lot of work. The amount of mice was probably a lot. I look forward to your future studies and learning what's happening at this endothelial renin cell junction. Maria Luisa Sequeira-Lopez:  Thank you. And we feel honored that you chose us. Ariel Gomez:               Yeah. Well, so I want to thank you for interviewing us. But I want to say that Hirofumi spent three years in the lab and he did a magnificent amount of work. Cindy St. Hilaire:        Wow. Yeah. I would have guessed a lot longer. Ariel Gomez:               Yeah. So he did a lot of work. And I'm very, very proud of what he has accomplished. Maria Luisa Sequeira-Lopez:  Yes. And I would like to add also that we were very lucky to have an expert in integrins, Dr DeSimone, who is the chair of Cell Biology at UVA and when we went and told him that we thought that this could be part of a mechanism sensing receptor, he started collaborating with us and opened his lab for us and trained Hirofumi with some experiments. It was really highly collaborative. Cindy St. Hilaire:        That's it for the highlights from our June 25th and July 19th issues of Circulation Research. Thank you for listening. Please check out the CircRes Facebook page and follow us on Twitter and Instagram with the handle @CircRes and #DiscoverCircRes. Thank you to our guests, Dr Hirofumi Watanabe, Dr Ariel Gomez, and Dr Maria Luisa Sequeira-Lopez. Cindy St. Hilaire:        This podcast was produced by Ashara Ratnayaka, edited by Melissa Stoner, and supported by the editorial team of Circulation Research. Some of the copy text for the highlighted articles was provided by Ruth Williams. I'm your host, Dr Cindy St. Hilaire, and this is Discover CircRes, your on-the-go source for the most exciting discoveries in basic cardiovascular research. This program is copyright of the American Heart Association, 2021. The opinions expressed by speakers in this podcast are their own and not necessarily those of the editors of the American Heart Association. For more information, please visit ahajournals.org.  

In Ep.16 of The Robot Brains Podcast, Pieter Abbeel sits down with AMP Robotics CEO and founder, Matanya Horowitz. Matanya is the founder and CEO of AMP Robotics, an industrial AI robotics company using automation to modernize recycling. An estimated $200bn worth of recyclable materials go un-recycled by municipal waste centres around the world. AMP's incredible "waste sorting robots" recover this recyclable material from waste at superhuman speeds and with extremely high accuracy. Matanya's AI-powered robots use advanced vision systems to recover valuable resources from junk, in the process, improving the ecological impact of waste on our environment. In his chat with Pieter, Matanya explains how he started AMP Robotics, why he decided to get into the trash business, and what he imagines the future of a "waste free world" will look like? Host: Pieter Abbeel | Executive Producers: Ricardo Reyes & Henry Tobias Jones | Audio Production: Kieron Matthew Banerji | Title Music: Alejandro Del Pozo See acast.com/privacy for privacy and opt-out information.

Today, we are building great-sounding direct acoustic tones for practice and recording using Positive Grid's Spark Amplifier. Show notes at: https://playguitarpodcast.com/direct-acoustic-tones-with-spark-amp-185/ Copyright ©2021 Play Guitar Academy

This is one of those podcasts I would recommend to ANYONE. In this show I am joined by my brother Daniele Bolelli: writer, professor, martial artist, and host of History On Fire and The Drunken Taoist podcasts. I brought him in to talk about a profound piece of literature that reveals deeper insights every time I pick it up--the Tao Te Ching. We go through numerous passages and explore their implications together. Along the way we make a slight detour, discussing one of my great heroes, Ikkyu Sojun. The rebellious, lascivious zen monk famous for the words “Throw me into hell, and I'll find a way to enjoy it.” This podcast is one of the best operating manuals for any situation life presents us with.    Connect with Daniele Bolelli Website | http://www.danielebolelli.com/ Twitter | https://twitter.com/dbolell   The Drunken Taoist Podcast | https://thedrunkentaoist.com/   History On Fire | http://historyonfirepodcast.com/   This episode is sponsored by: Native Deodorants Get %20 off  Native Deodorants | NativeDeo.com/Marcus or use the promo code "Marcus" at checkout   Kill Cliff Clean Energy and CBD Drinks visit Killcliff.com and use the code word AMP at Checkout for 20% OFF   Onnit Get 10% off Onnit products |  https://www.onnit.com/Aubrey/   Connect with Aubrey: Website | https://www.aubreymarcus.com/ Instagram | https://www.instagram.com/aubreymarcus/ Twitter | https://twitter.com/aubreymarcus Facebook | https://www.facebook.com/AubreyMarcus/ YouTube | https://bit.ly/2DLctpk   Check out  Own The Day Own Your Life by Aubrey Marcus|  https://bit.ly/2t6x4hu   Subscribe to the Aubrey Marcus Newsletter:  https://www.aubreymarcus.com/pages/email   Subscribe to the Aubrey Marcus Podcast: iTunes | https://apple.co/2lMZRCn Spotify | https://spoti.fi/2EaELZO Stitcher | https://bit.ly/2G8ccJt IHeartRadio | https://ihr.fm/397Msh0 Google Podcasts | https://bit.ly/3nzCJEh Android | https://bit.ly/2OQeBQg

Berberine belongs to a small group of natural products that have not only been used for thousands of years, but also are supported by significant amounts of research. If you're not using it to support your health, you could seriously be missing out. The first mention of a berberine-containing compound for medical use dates back to 200 A.D. Chinese medicine doctors have used it for treating neurological and digestive dysfunction for thousands of years. You can extract berberine from goldenseal, yellow root, Amur cork tree, Chinese goldthread, prickly poppy, and Californian poppy. Berberine capsules are bright yellow and taken at usual doses of 500 mg, up to three times per day. It has a strong safety record. Like curcumin, it acts on the body through multiple pathways, including its effect on AMP-activated protein kinase (AMPK). AMPK regulates metabolism in multiple organs as well as in your muscle tissue. As an aside, I've taken 1000 mg at bedtime consistently for the past couple of years. Cardiovascular Health To emphasize the impact berberine has on heart health, check out the following quote: Berberine has an antiarrhythmic effect, improves ejection fraction and enhances the function of the left ventricle and general physical capacity in congestive heart failure. Berberine decreases blood pressure by reducing cholesterol via several mechanisms, e.g., it stimulates the capture of cholesterol in serum by liver, stimulates the disposal of LDL-C from blood, reduces the absorption of cholesterol in bowels, enhances cholesterol excretion in excrements and stimulates liver exchange of cholesterol and the formation of bile acid.Och A, et al. With just this one health benefit alone, you have to wonder why more doctors don't talk about berberine. Research shows it improves the heart's performance while improving cholesterol levels and lowering blood pressure and triglycerides. That's pretty impressive, coming from a natural substance. Healthy Blood Sugar Levels Chronically elevated blood sugar leads to insulin resistance and type II diabetes. It may also cause premature aging, cognitive decline, and cancer. More than half of our adult population has insulin resistance, so to use a recently overused term, insulin resistance could be considered an epidemic. Following a good strength training program combined with a high-protein, low-carb or ketogenic diet is the most effective way to restore insulin sensitivity. Using berberine could speed up the process, though. Research shows berberine is as effective as Metformin in restoring insulin sensitivity and normalizing blood sugar levels. Studies show it provides benefits on its own, as well as when combined with chromium picolinate, inositol, curcumin, and banaba. Women with Polycystic Ovary Syndrome (PCOS) are often insulin resistant as well. At a dose of 500 mg per day, berberine supplementation not only improved insulin sensitivity and reduced elevated androgen levels in women with PCOS, it also improved pregnancy rates. Body Composition Berberine suppresses adipogenesis and lipogenesis, or the growth of fat cells. Combined with its effect in lowering blood sugar, and thereby limiting insulin secretion, berberine may be a good alternative therapy for obesity, or for simply maintaining a healthy body fat level. Of course, if you're serious about improving your body composition, you'll need to follow a good workout program and eat a healthy, high-protein diet as well. You can't just rely on a supplement like berberine. Cognitive Function Most adults know someone with Alzheimer's Disease or some form of dementia. Seeing someone literally lose their mind is both sad and scary. If you know the feeling, and are serious about avoiding cognitive decline, consider using berberine along with other healthy diet and lifestyle choices. Berberine also inhibits the brain's reward center after using drugs like cocaine,

http://anacortesmusicproject.org/quaran-tunes-1-the-next-show-july-2021/feed/ 0 Podcasts – Anacortes Mu

If you're watching this channel, then chances are you love crypto. But what if you actually wanted to spend those hard-earned gains day today? To give up the petro-dollar for good? Say you wanted to treat Grandma to a snazzy new walking cane. Well, in the unlikely event that the local cane store accepted crypto payments, would you really risk Grandma having to stand around for hours as you waited for the transaction to be confirmed? But what if there was a technology out there that allowed you to spend your favorite cryptos at any available payment terminal. And better yet, what if those payments faster and more secure. Sound too good to be true? Well, that pipe-dream may soon be a reality, thanks to the AMP, an ECR20 token many expect to send shockwaves through the global payments industry.

Today Seth & Shelby discuss the creepy effects that a partial nuclear meltdown has had on the wildlife. Also, we'll be discussing a new water park set to arrive in Irvine and how underground gambling may have gotten out of control here in Orange County.Join us for this episode of “Drive Time OC”, Shelby & Seth discuss what's going on in Orange County CA. If it's important to them, it should be important to you!HeadlineSeth - Radioactive Terror Pigs And How to Avoid Them…Web - https://www-theregister-com.cdn.ampproject.org/c/s/www.theregister.com/AMP/2021/07/01/radioactive_hybrid_terror_pigs_fukushima/“OC Real-Estate with Daniel Preszler”HeadlineShelby - Wild Rivers Water Park: Construction to begin in IrvineWeb -https://www.ocregister.com/2021/07/08/new-wild-rivers-water-park-breaks-ground-in-irvine/In Other NewsSeth - Orange County, Calif. Cops Continue Crackdown on Illegal Gambling DensWeb - https://www.casino.org/news/orange-county-calif-cops-continue-crackdown-on-illegal-gambling-dens/Shelby - Bite & a SipBest breakfast burritos: Rose Bakery Cafe in CDMWeb - https://www.rosebakerycafe.com/#breakfast-and-lunch-corona-del-marWeb- https://keancoffee.comWeb- http://www.kit.coffee/homeEventsShelby - US Open of surfing in Huntington Beach will return this year Web - https://www.ocregister.com/2021/07/07/u-s-open-of-surfing-is-a-go-what-to-know-about-the-events-new-dates-and-format/Seth - OPENING: Festival Of Arts & Pageant Of Masters 2021: Laguna BeachWeb - https://www.foapom.com/about/LinksDrive Time OCWeb - https://sitchradio.com/our-shows/drive-time-oc/Twitter - https://twitter.com/DriveTimeOCInstagram - https://www.instagram.com/drivetimeoc/TikTok - https://www.tiktok.com/@drivetimeocFacebook - Facebook - https://www.facebook.com/DriveTimeOCSponsors“OC Real-Estate with Daniel”Daniel Preszler - (714) 788-7525 Email - 714ocre@gmail.comFoskaris Wellness - https://foskariswellness.com/Sitch Radio - https://sitchradio.com/If you would like to become a sponsor or advertiser Call Sitch Radio (714) 643-2500 X 1

Rob Writz is director of commercial partnerships for AMP Robotics; his professional career has focused on the intersection of software with the circular economy and safety. Before joining AMP in 2016, Writz was a product manager for Intrado (acquired by West), worked in technology commercialization at The Department of Energy's National Renewable Energy Laboratory, and led the Cleantech Practice at Innosphere, Colorado's seed fund and incubator for science-based startups. AMP Robotics is a pioneer and leader in artificial intelligence (AI), robotics, and infrastructure for the waste and recycling industry.

In today's podcast I am joined by the Board-Certified Psychiatrist and Neuroscientist, Dr. Dave Rabin. In this long overdue conversation, we talk about how ketamine assisted therapy is leading a mental health revolution. As with many psychedelic medicines, ketamine in the right setting can be a powerful ally to help us rewrite traumatic emotional experiences. In addition, ketamine therapy can help us manifest our desired reality from the quantum realm of all possibility.   Get %15 off Apollo by visiting https://apolloneuro.com/aubrey   Connect with Dr. Dave Rabin Website | https://www.drdave.io/ Instagram | https://www.instagram.com/drdavidrabin/ Twitter | https://twitter.com/DaveRabin   This episode is sponsored by:   EIGHT SLEEP Go to eightsleep.com/AMP to check out the Pod Pro and save $150 by using the promo Code  AMP at checkout   Kill Cliff Clean Energy and CBD Drinks visit Killcliff.com and use the code word AMP at Checkout for 20% OFF   Onnit Get 10% off Onnit products |  https://www.onnit.com/Aubrey/   Connect with Aubrey: Website | https://www.aubreymarcus.com/ Instagram | https://www.instagram.com/aubreymarcus/ Twitter | https://twitter.com/aubreymarcus Facebook | https://www.facebook.com/AubreyMarcus/ YouTube | https://bit.ly/2DLctpk   Check out  Own The Day Own Your Life by Aubrey Marcus|  https://bit.ly/2t6x4hu   Subscribe to the Aubrey Marcus Newsletter:  https://www.aubreymarcus.com/pages/email   Subscribe to the Aubrey Marcus Podcast: iTunes | https://apple.co/2lMZRCn Spotify | https://spoti.fi/2EaELZO Stitcher | https://bit.ly/2G8ccJt IHeartRadio | https://ihr.fm/397Msh0 Google Podcasts | https://bit.ly/3nzCJEh Android | https://bit.ly/2OQeBQg  

44bits 팟캐스트 120번째 로그에서는 44bits 팟캐스트 120.log : 인덴트코퍼레이션 프리A 투자, CodeCov 깃헙 토큰 유출, Google 검색결과에 AMP 가산점 제거에 대해서 이야기를 나누었습니다. 참가자: @nacyo_t, @seapy, @raccoonyy 정기 후원 - 44bits podcast are creating 프로그래머들의 팟캐스트 녹음일 5월 27일, 공개일 7월 5일 쇼노트: https://stdout.fm/120/ 주제별 바로 듣기 00:00 시작 00:38 인덴트코퍼레이션 프리A 투자 유치 06:15 CodeCov 깃헙 토큰 유출 27:24 Google 검색결과에 AMP 가산점 제거 44:24 Mac M1 개발자들이 쓰는것에 대한 이야기 쇼노트 인덴트코퍼레이션 프리A 투자 유치 ‘브이리뷰' 운영사 인덴트코퍼레이션, 45억 규모 프리A 투자 유치 야놀자 나스닥 직행…손정의 2조원 투자 | 한경닷컴 - hankyung.com 인덴트코퍼레이션 채용 페이지 CodeCov 깃헙 토큰 유출 Codecov - The Leading Code Coverage Solution Mercari's Response to the Codecov Vulnerability and Related Notification on Personal Information Exposure | Mercari, inc Google 검색결과에 AMP 가산점 제거 More time, tools, and details on the page experience update - Google Developers Largest Contentful Paint (LCP) - web.dev First Input Delay (FID) - web.dev Cumulative Layout Shift (CLS) - web.dev

On this special bonus episode, Cat and Joe discuss and review the very popular Season 1 of Demon Slayer, as well as the recent Demon Slayer movie, Demon Slayer: Mugen Train (2020). The AMP team got to see this one in an actual theater with actual popcorn and everything, which was a very exciting post-quarantine treat. Demon Slayer: Mugen Train became the first non-American film to top an annual box office, becoming the highest grossing movie of 2020. It was released outside of Japan in the spring of 2021, and has since replaced Your Name (Makoto Shinkai, 2016) as the highest grossing anime movie of all time, and is also the highest grossing Japanese film ever made. The film acts as a direct sequel to the first season, so Cat and Joe discuss the important parts of the series that lead up to the events that take place in the film, and they also make predictions for Season 2, set to be released in October 2021. This special bonus episode is also available as a video podcast - search YouTube for The Anime Movie Podcast to watch! The series is available to stream on Netflix. The film is streaming exclusively on Funimation, though it's also available for digital purchase from YouTube, Amazon Prime, Apple TV, Google Play & Vudu. It may also still be possible to watch in theaters if you're listening in the Summer of 2021!

Become a Patreon Supporter! - http://bit.ly/RAOPPatreon On this weeks episode of RAOP we celebrate our first episode in the new studio with the homie Cam. We read listener questions and Keef calls in to talk shit about the Hawks/Sixers bet made with Amp smh. Enjoy! Remember to send in your listener questions, #TheyNeedTheirAssBeat or #RealNiggaOfTheWeek submissions, email us at MAIL@RAOPodcast.com or call 424-260-RAOP to leave a voicemail.

In today's podcast I am joined by my brother Erick Godsey to talk about the life changing lessons that came from my recent Ayahuasca ceremonies. This was new territory for me as the facilitation was very different from anything I've ever experienced. I describe my experiences in ceremony, my encounter with a very powerful being, and the psychological insights that followed. A potent theme in this conversation is judgment; we explore how it hinders our expressions as divine beings and the only way I've found to truly move through it. Check out The Dharma Journal  here | https://bit.ly/TDGAMPM   This episode is sponsored by: Kill Cliff Clean Energy and CBD Drinks visit Killcliff.com and use the code word AMP at Checkout for 20% OFF   LUCY.CO Get %20 off Lucy Nicotine Gum | LUCY.CO and use the promo code AMP at checkout   Onnit Get 10% off Onnit products |  https://www.onnit.com/Aubrey/   Connect with Erick Godsey: Website | https://www.erickgodsey.com/ Instagram | https://www.instagram.com/erickgodzey/ Twitter | https://twitter.com/erickgodsey?lang=en    Subscribe to The Myths That Make Us podcast: Itunes | https://apple.co/2Je6RG4 Stitcher | https://bit.ly/2TbivRD Spotify | https://spoti.fi/2XZMakj   Connect with Aubrey: Website | https://www.aubreymarcus.com/ Instagram | https://www.instagram.com/aubreymarcus/ Twitter | https://twitter.com/aubreymarcus Facebook | https://www.facebook.com/AubreyMarcus/ YouTube | https://bit.ly/2DLctpk   Check out  Own The Day Own Your Life by Aubrey Marcus|  https://bit.ly/2t6x4hu   Subscribe to the Aubrey Marcus Newsletter:  https://www.aubreymarcus.com/pages/email   Subscribe to the Aubrey Marcus Podcast: iTunes | https://apple.co/2lMZRCn Spotify | https://spoti.fi/2EaELZO Stitcher | https://bit.ly/2G8ccJt IHeartRadio | https://ihr.fm/397Msh0 Google Podcasts | https://bit.ly/3nzCJEh Android | https://bit.ly/2OQeBQg

"Well" with My Soul" Part 17 John 4:25-30 (NIV) – [25] The woman said, “I know that Messiah” (called Christ) “is coming. When he comes, he will explain everything to us.” [26] Then Jesus declared, “I who speak to you am he.” [27] Just then his disciples returned and were surprised to find him talking with a woman. But no one asked, “What do you want?” or “Why are you talking with her?” [28] Then, leaving her water jar, the woman went back to the town and said to the people, [29] “Come, see a man who told me everything I ever did. Could this be the Christ?” [30] They came out of the town and made their way toward him. 1. Know the Messiah for yourself. Matthew 16:16, 20 (NIV) – [16] Simon Peter answered, “You are the Christ, the Son of the living God.” [20] Then he warned his disciples not to tell anyone that he was the Christ. John 3:16 (AMP) – [16] For God so greatly loved and dearly prized the world that He [even] gave up His only begotten (unique) Son, so that whoever believes in (trusts in, clings to, relies on) Him shall not perish (come to destruction, be lost) but have eternal (everlasting) life. 2. God surprises us sometimes. 3. Be careful when questioning God. Mark 7:17-18 (NIV) – [17] After he had left the crowd and entered the house, his disciples asked him about this parable. [18] “Are you so dull?” he asked. Job 38:1-3 (NLT) – [1] Then the LORD answered Job from the whirlwind: [2] "Who is this that questions my wisdom with such ignorant words? [3] Brace yourself like a man, because I have some questions for you, and you must answer them. 4. Leave your water jar behind. Matthew 4:18-22 (NIV) – [18] As Jesus was walking beside the Sea of Galilee, he saw two brothers, Simon called Peter and his brother Andrew. They were casting a net into the lake, for they were fishermen. [19] “Come, follow me,” Jesus said, “and I will make you fishers of men.” [20] At once they left their nets and followed him. [21] Going on from there, he saw two other brothers, James son of Zebedee and his brother John. They were in a boat with their father Zebedee, preparing their nets. Jesus called them, [22] and immediately they left the boat and their father and followed him. Luke 18:28-29 (NIV) – [28] Peter said to him, “We have left all we had to follow you!” [29] “I tell you the truth,” Jesus said to them, “no one who has left home or wife or brothers or parents or children for the sake of the kingdom of God 5. Call others to come and see. John 1:44-46 (NIV) – [44] Philip, like Andrew and Peter, was from the town of Bethsaida. [45] Philip found Nathanael and told him, “We have found the one Moses wrote about in the Law, and about whom the prophets also wrote—Jesus of Nazareth, the son of Joseph.” [46] “Nazareth! Can anything good come from there?” Nathanael asked. “Come and see,” said Philip.

German musician Thomas Blug follows in the traditions of Les Paul and Tom Scholtz. He is an astounding guitarist with a passion - and career - in cutting edge guitar gear, having spent years designing for Hughes and Kettner and now seeing his own Blu Guitar innovations take hold around the world. His Amp 1 is played by Jennifer Batten, Jude Gold and Kat Dyson, to name a few pros. Thomas joins us the morning after a gig to tell the story of his own playing career, the products he designed for H & K and of course his own Blu Guitar range including the Amp 1,  the custom shop '61 guitar - based on Thomas' own vintage Fender, with a few tweaks - and get a pre-release preview of the Amp X, a comprehensive amp and effects system to be released at NAMM 2022. bluguitar.com This episode is brought to you by Fretboard Biology and The Pedal Movie                                Fretboard Biology - the online guitar college created by Joe Elliott, ex Head of Guitar at GIT and McNally Smith Music College. Fretboard Biology Guitar Speak Podcast #146 - Joe Elliott - ex guitar head of GIT - launches Fretboard Biology   'The Pedal Movie' - the full length feature film that is all about effects pedals, produced by music marketplace Reverb. The Pedal Movie GSP #154 with The Pedal Movie Directors Michael Lux and Dan Orkin   Guitar Speak Podcast Links PayPal Tip Jar Visit us at guitarspeakpodcast.com Subscribe and find previous episodes at: Apple Podcasts Spotify Stitcher   Follow us on Facebook & Instagram Buy a T-Shirt! Contact us at guitarspeakpodcast@gmail.com

Hilary B. Jones, musician, former Girls Rock Camp director/guitar salesperson, professor of gender studies and psychology, and host of Mid-Riff Podcast is this week's guest! She and LG talk about everything from podcastin' to rockin' to the intersection of gender and music. Two podcast hosts talking shop in part one of this powerhouse interview. Thank you to EarthQuaker Devices www.earthquakerdevices.com for sponsoring this podcast. Support this podcast and women in audio at patreon.com/QOSM and get some merch at society6.com/QOSM! 

In today's podcast I am joined by my brother, master musician and medicine man, Porangui. Typical of most of my conversations with Porangui, this podcast was its own kind of medicine journey for me. We cover a lot of ground, including the sun dance ceremony, my recent bodywork apprenticeship, and Porangui plays some stunning songs that bring me to tears.    Connect with Porangui: Website | https://www.porangui.com/ Facebook | https://www.facebook.com/porangui Instagram | https://www.instagram.com/porangui/ Twitter | https://twitter.com/porangui YouTube | https://www.youtube.com/user/porangui Spotify | https://spoti.fi/2ECCRPq   This episode is sponsored by: Onnit Get 10% off Onnit products |  https://www.onnit.com/Aubrey/   EIGHT SLEEP Go to eightsleep.com/AMP to check out the Pod Pro and save $150 by using the promo Code  AMP at checkout   Kill Cliff Clean Energy and CBD Drinks visit Killcliff.com and use the code word AMP at Checkout for 20% OFF   Connect with Aubrey: Website | https://www.aubreymarcus.com/ Instagram | https://www.instagram.com/aubreymarcus/ Twitter | https://twitter.com/aubreymarcus Facebook | https://www.facebook.com/AubreyMarcus/ YouTube | https://bit.ly/2DLctpk   Check out  Own The Day Own Your Life by Aubrey Marcus|  https://bit.ly/2t6x4hu   Subscribe to the Aubrey Marcus Newsletter:  https://www.aubreymarcus.com/pages/email   Subscribe to the Aubrey Marcus Podcast: iTunes | https://apple.co/2lMZRCn Spotify | https://spoti.fi/2EaELZO Stitcher | https://bit.ly/2G8ccJt IHeartRadio | https://ihr.fm/397Msh0 Google Podcasts | https://bit.ly/3nzCJEh Android | https://bit.ly/2OQeBQg

Brian and Blake are back with another episode of the Chasing Tone Podcast, and this week they are joined by Travis Feaster. Blake's conundrum - Should he swap his 6 String Rickenbacker 360 for a vintage Orange cab? The guys discuss how Rickenbacker manufacture their guitars and Travis shares some insider info on their production process. Travis describes his haggling nature and the guys talk about gear trading in general. Travis taps into Brian's hip and happening nature with a question about impulse responses and the guys have an in-depth discussion about IRs and Amp simulations…and then concludes what we all know, that the SLO 30 is the greatest amp on the planet.Brian also has a conundrum with mixing again and has been to Youtube university to learn a bit more so the guys have a chat about mixing while Blake becomes increasingly nervous about his vintage cab falling into the hands of someone who wont love it as much as him.What are the two biggest factors in an amplifier's sound ? You may be surprised to hear it isn't the tubes…Blake gets angry with realtors, Travis plays “older” country gigs, Magnetic arm foolishness, it's all in this weeks episode of Chasing Tone!DIY modshttps://modyourownpedal.com/collections/booksFind us at:https://www.wamplerpedals.com/https://www.instagram.com/WamplerPedals/https://www.facebook.com/groups/wamplerfanpage/Youtube:https://www.youtube.com/channel/UCdVrg4Wl3vjIxonABn6RfWwContact us at: podcast@wamplerpedals.com

#8 from 2020 Technology and Parenting with Arlene Pellicane   Titus 2:15 (AMP) “Tell them these things. Encourage and rebuke with full authority. Let no one disregard or despise you [conduct yourself and your teaching so as to command respect.]"   Arlene Pellicane is a speaker and author of several books including Parents Rising, 31 Days to a Happy Husband and Calm, Cool, and Connected: 5 Digital Habits for a More Balanced Life.   She is also the co-author of Growing Up Social: Raising Relational Kids in a Screen-Driven World (with Dr. Gary Chapman).     Arlene has been a featured guest on the Today Show, Fox & Friends, Focus on the Family, FamilyLife Today, The 700 Club, and Turning Point with Dr. David Jeremiah.  She writes regularly for Proverbs 31 Ministries and Girlfriends in God.  Arlene earned her BA from Biola University and her Masters in Journalism from Regent University.  Arlene lives in San Diego with her husband James and their three children Ethan, Noelle, and Lucy.  To learn more, visit www.ArlenePellicane.com    Arlene Pellicane's Website Arlene Pellicane's Podcast   At The Savvy Sauce, we will only recommend resources we believe in! We also want you to be aware: We are a participant in the Amazon Services LLC Associates Program, an affiliate advertising program designed to provide a means for us to earn fees by linking to Amazon.com and affiliated sites.    Growing up Social by Dr. Gary Chapman and Arlene Pellicane   Books by Arlene Pellicane: Parents Rising 31 Days to a Happy Husband 31 Days to Becoming a Happy Mom 31 Days to Becoming a Happy Wife 31 Days to a Younger You Calm, Cool, and Connected: 5 Digital Habits for a More Balanced Life   Outliers by Malcolm Gladwell Anger: Taming a Powerful Emotion by Dr. Gary Chapman   Thank You to Our Sponsor:  Faithful Counseling (10% off your first month of counseling when you sign up through this link)   Connect with The Savvy Sauce on Facebook or Instagram or Our Website   Please help us out by sharing this episode with a friend, leaving a 5-star rating and review, and subscribing to this podcast!   Also, check out our Patreon Page to find out how to gain access to additional podcasts and freebies!   Gospel Scripture: (all NIV)   Romans 3:23 “for all have sinned and fall short of the glory of God,”   Romans 3:24 “and are justified freely by his grace through the redemption that came by Christ Jesus.”   Romans 3:25 (a) “God presented him as a sacrifice of atonement, through faith in his blood.”    Hebrews 9:22 (b) “without the shedding of blood there is no forgiveness.”    Romans 5:8 “But God demonstrates his own love for us in this: While we were still sinners, Christ died for us.”    Romans 5:11 “Not only is this so, but we also rejoice in God through our Lord Jesus Christ, through whom we have now received reconciliation.”    John 3:16 “For God so loved the world that he gave his one and only Son, that whoever believes in him shall not perish but have eternal life.”   Romans 10:9 “That if you confess with your mouth, “Jesus is Lord,” and believe in your heart that God raised him from the dead, you will be saved.”    Luke 15:10 says “In the same way, I tell you, there is rejoicing in the presence of the angels of God over one sinner who repents.”   Romans 8:1 “Therefore, there is now no condemnation for those who are in Christ Jesus”   Ephesians 1:13–14 “And you also were included in Christ when you heard the word of truth, the gospel of your salvation. Having believed, you were marked in him with a seal, the promised Holy Spirit, who is a deposit guaranteeing our inheritance until the redemption of those who are God's possession- to the praise of his glory.”   Ephesians 1:15–23 “For this reason, ever since I heard about your faith in the Lord Jesus and your love for all the saints, I have not stopped giving thanks for you, remembering you in my prayers. I keep asking that the God of our Lord Jesus Christ, the glorious Father, may give you the spirit of wisdom and revelation, so that you may know him better. I pray also that the eyes of your heart may be enlightened in order that you may know the hope to which he has called you, the riches of his glorious inheritance in the saints, and his incomparably great power for us who believe. That power is like the working of his mighty strength, which he exerted in Christ when he raised him from the dead and seated him at his right hand in the heavenly realms, far above all rule and authority, power and dominion, and every title that can be given, not only in the present age but also in the one to come. And God placed all things under his feet and appointed him to be head over everything for the church, which is his body, the fullness of him who fills everything in every way.”   Ephesians 2:8–10 “For it is by grace you have been saved, through faith – and this not from yourselves, it is the gift of God – not by works, so that no one can boast. For we are God‘s workmanship, created in Christ Jesus to do good works, which God prepared in advance for us to do.“   Ephesians 2:13 “But now in Christ Jesus you who once were far away have been brought near through the blood of Christ.“   Philippians 1:6 “being confident of this, that he who began a good work in you will carry it on to completion until the day of Christ Jesus.”

Don Miguel Ruiz is the only true mystic I have ever met in person. Spending a week with him changed my life forever, because it showed me that it was possible to escape suffering and embrace life fully. I am joined today by his son, Don Jose, who is carrying on the Toltec lineage of his father. This podcast goes way beyond the Four Agreements, including all the lessons on how to live, love and die like a spiritual master. This is one of the highlight experiences of the Aubrey Marcus Podcast.   Check out don Miguel Ruiz's new Book The Actor | https://bit.ly/3vu5hm7 Connect with don Miguel Ruiz Instagram | https://www.instagram.com/donmiguelruiz/ Twitter | https://twitter.com/donMiguelRuiz Facebook | https://www.facebook.com/donMiguelRuiz YouTube | https://bit.ly/3pZQePT   Check out don Jose Ruiz's new book Shamanic Power Animals | https://amzn.to/3gBqsxf Connect with don Jose Ruiz Instagram | https://www.instagram.com/donjoseruiz/ Facebook | https://www.facebook.com/ToltecLife   This episode is sponsored by: Onnit Get 10% off Onnit products |  https://www.onnit.com/Aubrey/   LUCY.CO Get %20 off Lucy Nicotine Gum | LUCY.CO and use the promo code AMP at checkout   Kill Cliff Clean Energy and CBD Drinks visit Killcliff.com and use the code word AMP at Checkout for 20% OFF   Connect with Aubrey: Website | https://www.aubreymarcus.com/ Instagram | https://www.instagram.com/aubreymarcus/ Twitter | https://twitter.com/aubreymarcus Facebook | https://www.facebook.com/AubreyMarcus/ YouTube | https://bit.ly/2DLctpk   Check out  Own The Day Own Your Life by Aubrey Marcus|  https://bit.ly/2t6x4hu   Subscribe to the Aubrey Marcus Newsletter:  https://www.aubreymarcus.com/pages/email   Subscribe to the Aubrey Marcus Podcast: iTunes | https://apple.co/2lMZRCn Spotify | https://spoti.fi/2EaELZO Stitcher | https://bit.ly/2G8ccJt IHeartRadio | https://ihr.fm/397Msh0 Google Podcasts | https://bit.ly/3nzCJEh Android | https://bit.ly/2OQeBQg  

In this podcast I am joined by one of the very few people on earth who has scientifically studied DMT,  Dr. Jon Dean, and John Chavez, founder of DMT Quest. We talk about the research that has been conducted over this mystical and controversial compound, and the potential implications of such findings. Jon recently published a study that has ended the debate on whether or not DMT is produced endogenously in the mammalian brain. It is. We've entered a renaissance of psychedelic study; this is just the beginning and it's going to take a concerted effort to fund, support, and advocate for the proliferation of this research. Check out the DMT Quest documentary | https://bit.ly/3ce3Cdz   This episode is sponsored by:   Native Deodorants Get %20 off  Native Deodorants | NativeDeo.com/Marcus or use the promo code "Marcus" at checkout   Vivobarefoot Get 20% off Vivo footwear and 100 day Free Trial by visiting Vivobarefoot.com/AMP and using the code “AMP”at checkout   Onnit Get 10% off Onnit products |  https://www.onnit.com/Aubrey/   Connect with Aubrey: Website | https://www.aubreymarcus.com/ Instagram | https://www.instagram.com/aubreymarcus/ Twitter | https://twitter.com/aubreymarcus Facebook | https://www.facebook.com/AubreyMarcus/ YouTube | https://bit.ly/2DLctpk   Check out  Own The Day Own Your Life by Aubrey Marcus|  https://bit.ly/2t6x4hu   Subscribe to the Aubrey Marcus Newsletter:  https://www.aubreymarcus.com/pages/email   Subscribe to the Aubrey Marcus Podcast: iTunes | https://apple.co/2lMZRCn Spotify | https://spoti.fi/2EaELZO Stitcher | https://bit.ly/2G8ccJt IHeartRadio | https://ihr.fm/397Msh0 Google Podcasts | https://bit.ly/3nzCJEh Android | https://bit.ly/2OQeBQg