Podcasts about national institutes

Patreon | Episodes | Subscribe | Spotify | YouTube | Newsletter | Contact | Swag! | CME Show Segments Intro Case: Jeremy Wearable devices inaccuracies Ideal blood pressure measurement Diagnosis and workup Management and fixed-dose combination pills Case: Jolene and pregnancy Outro Credits Written and Produced by: Deborah Gorth MD, PhD Infographic and Cover Art by: Deborah Gorth MD, PhD and Meryl Gorth RD, MPH Hosts: Matthew Watto MD, FACP; Paul Williams MD, FACP    Reviewer: Emi Okamoto MD Showrunners: Matthew Watto MD, FACP; Paul Williams MD, FACP Technical Production: PodPaste Guest: Jordana Cohen MD, MSCE Disclosures Financial Relationships disclosed for Dr. Jordana Cohen: Wolters Kluwer (Royalties or Patent Beneficiary) and National Institutes of Health (Grant or research support) Sponsor: FIGS We've teamed up with FIGS, and now Curbsiders listeners can get 15% off. Just go to WearFIGS.com and use code FIGSRX.   Sponsor: MasterClass MasterClass always has great offers during the holidays, sometimes up to as much as 50% off. Head over to masterclass.com/CURB for the current offer. Sponsor: Quince Go to Quince.com/curb for free shipping on your order and 365-day returns.

Is 19 Too Young To Be a Police Officer? A Florida, USA Perspective on Trauma Impact and PTSD. Special Episode. At just 19 years old, Michael A. Laidler was already wearing a badge and responding to some of the most intense calls a police officer can face. Sworn in as a police officer in Tallahassee, Florida, USA, his early entry into law enforcement placed him on the front lines at an age when most of his peers were still navigating college life or their first civilian jobs. The question at the heart of this Special Episode is simple, yet deeply complex: Is 19 too young to be a police officer? Look for The Law Enforcement Talk Radio Show and Podcast on social media like their Facebook , Instagram , LinkedIn , Medium and other social media platforms. Michael's story, shared through the Podcast available for free on the Law Enforcement Talk Radio Show and Podcast website, on Apple Podcasts, Spotify, Youtube and most major podcast platforms, offers a rare firsthand look at how early exposure to trauma can shape both a career and a life. “At 19, I thought I was ready,” Michael reflects. “I passed the tests, I met the requirements, but nothing truly prepares you for repeated exposure to trauma at that age.”  Supporting articles about this and much more from Law Enforcement Talk Radio Show and Podcast in platforms like Medium , Blogspot and Linkedin . Trauma at the Start of a Career Early in his career, Michael encountered extreme stress and traumatic incidents that would leave lasting impressions. He recounts two particularly disturbing events that occurred while he was still a teenager in uniform, experiences that many officers don't face until years into the job. Is 19 Too Young To Be a Police Officer? A Florida, USA Perspective on Trauma Impact and PTSD. Special Episode. Available for free on their website and streaming on Apple Podcasts, Spotify, Youtube and other podcast platforms. “You don't just see trauma,” he explains. “You absorb it. And when you're that young, it hits differently.” These experiences didn't just affect his work performance; they influenced his personal life, emotional regulation, and long-term career decisions. Like many officers of his generation, Michael says there was little discussion about mental health, PTSD, or the long-term Trauma Impact on young officers. “Back then, the mindset was to tough it out,” he says. “You handled it the best you could, often without the tools or language to understand what was happening inside.” The Science Behind Age and Trauma In the United States, the minimum age to become a police officer typically ranges from 18 to 21, depending on the state and department. Florida is unique in that it sets the minimum age for sworn law enforcement officers at 19 years old, while corrections officers may be hired at 18. However some agencies have higher minimum ages. Research suggests that while 18 and 19-year-olds possess adult-level reasoning abilities, the brain, particularly the prefrontal cortex responsible for impulse control, emotional regulation, and decision-making, continues to develop well into the early 20s. This ongoing development may make younger officers more vulnerable to the effects of repeated traumatic exposure. Is 19 Too Young To Be a Police Officer? A Florida, USA Perspective on Trauma Impact and PTSD. Special Episode. The Law Enforcement Talk Radio Show and Podcast episode is available for free on their website , Apple Podcasts , Spotify and most major podcast platforms. Studies cited by the National Institutes of Health indicate that trauma exposure can double the risk of major depressive disorder and is a key criterion for developing PTSD. Adolescents and young adults may be especially susceptible, as trauma can intersect with critical stages of identity formation and emotional development. “You're still becoming who you are,” Michael notes. “When trauma gets layered onto that process, it can redirect your entire path.” Florida Standards and the Bigger Debate Under Florida Statute 943.13, individuals seeking certification as law enforcement officers must meet strict criteria, including U.S. citizenship, a high school diploma or GED, good moral character, and a clean criminal history. In cities like Miami, applicants must be at least 19 years old to apply. The interview can be found on The Law Enforcement Talk Radio Show and Podcast website, on Apple podcasts, Spotify, Youtube and on LinkedIn, Facebook, Instagram, and across most podcast platforms where listeners will find authentic law enforcement stories. While these standards ensure legal and ethical readiness, they don't fully address developmental readiness or long-term mental health outcomes. Critics argue that agencies should more seriously consider age, maturity, and access to trauma-informed support systems when hiring young officers. According to broader research, trauma experienced during sensitive developmental periods may carry a higher risk for long-term psychological effects, including PTSD, substance abuse, and relationship difficulties, especially if left untreated. Is 19 Too Young To Be a Police Officer? A Florida, USA Perspective on Trauma Impact and PTSD. Special Episode. Turning Pain Into Purpose Today, Michael A. Laidler uses his experiences to help others. His career path ultimately shifted toward leadership development and training, driven by a desire to support officers before trauma defines them. “If sharing my story helps even one young officer recognize the signs of PTSD or seek help earlier, then it's worth it,” he says. The full podcast episode is streaming now on their website, on Apple Podcasts, Spotify, Youtube and across Facebook, Instagram, and LinkedIn. This Special Episode isn't just about age requirements or policy, it's about people, development, and the hidden costs of early exposure to trauma in law enforcement. As the conversation continues across News, Podcast, and social media platforms, Michael's story adds an essential human perspective to the ongoing debate. “Nineteen isn't too young to care,” Michael concludes. “But it might be too young to carry trauma alone.” Listeners can tune in on the Law Enforcement Talk Radio Show website, on Apple Podcasts, Spotify, YouTube, and most every major Podcast platform and follow updates on Facebook, Instagram, and other major News outlets. You can find the show on Facebook, Instagram, Pinterest, X (formerly Twitter), and LinkedIn, as well as read companion articles and updates on Medium, Blogspot, YouTube, and even IMDB. You can help contribute money to make the Gunrunner Movie . The film that Hollywood won't touch. It is about a now Retired Police Officer that was shot 6 times while investigating Gunrunning. He died 3 times during Medical treatment and was resuscitated. You can join the fight by giving a monetary “gift” to help ensure the making of his film at agunrunnerfilm.com . Background song Hurricane is used with permission from the band Dark Horse Flyer. You can contact John J. “Jay” Wiley by email at Jay@letradio.com , or learn more about him on their website . Stay connected with updates and future episodes by following the show on Facebook, Instagram, LinkedIn, their website and other Social Media Platforms. Find a wide variety of great podcasts online at The Podcast Zone Facebook Page , look for the one with the bright green logo. Be sure to check out our website . Be sure to follow us on X , Instagram , Facebook, Pinterest, Linkedin and other social media platforms for the latest episodes and news. Is 19 Too Young To Be a Police Officer? A Florida, USA Perspective on Trauma Impact and PTSD. Special Episode. Attributions FDLE Miami Government Wikipedia N.I.H. Michael Laidler Hosted by Simplecast, an AdsWizz company. See pcm.adswizz.com for information about our collection and use of personal data for advertising.

#ThisMorning | #Aging in Place: Growing #Older at #Home | Erin Harrell, PhD., National Institute on Aging | #Tunein: broadcastretirementnetwork.com #Aging, #Finance, #Lifestyle, #Privacy, #Retirement, #Wellness

Conflicting jobs data indicates a complex economic landscape for IT service providers, as the unemployment rate in the tech sector has risen to 4% with a loss of 134,000 jobs between October and November 2025. Despite a drop in the overall unemployment rate to 4.2% and a projected growth of managed services contributing $608 billion to the B2B technology sector, the mixed signals from economic indicators complicate decision-making for the Federal Reserve and raise concerns about consumer spending. Analysts emphasize that the current job losses reflect a shift in responsibility from internal roles to external managed service providers (MSPs), which may not alleviate underlying risks.The National Institute of Standards and Technology (NIST) has released a draft profile addressing cybersecurity challenges posed by artificial intelligence (AI), highlighting the need for organizations to manage AI-related security risks effectively. This profile outlines how AI can enhance cybersecurity defenses while also detailing the responsibilities that come with its deployment. Recent assessments reveal that while some AI models perform better in security contexts, the lack of clarity around accountability when AI systems make decisions remains a significant concern for MSPs.Private equity activity is accelerating in the managed services sector, exemplified by Broadwing Capital's acquisition of CloudScale365, which aims to create a platform addressing gaps in the fragmented IT-managed services market. This consolidation trend raises questions for MSPs about operational norms and the potential loss of control over their business models. As platforms seek to standardize pricing and decision-making processes, MSPs must consider how these changes will affect their service delivery and customer relationships.For MSPs and IT service leaders, the evolving landscape underscores the importance of understanding where risk is shifting and how to price and govern accordingly. The retreat from AGI hype and the focus on practical AI applications signal a need for clarity in decision-making processes, particularly as automation becomes more prevalent. MSPs that can articulate the limitations of their AI systems and establish clear accountability frameworks will be better positioned to navigate the complexities of the current market. Four things to know today00:00 As Jobs Data Conflicts and Tech Employment Slips, Managed Services Absorb Risk and Responsibility05:46 NIST's AI Security Framework Meets Reality as Model Safety Gaps Expose Accountability Risks08:54 Broadwing Launches MSP Platform to Standardize Scale, Signaling Growing PE Pressure on MSP Operations11:03 AI Rebrands Itself as Open Source Expands, Automation Scales, and Accountability Gets Murkier This is the Business of Tech.    Supported by:  https://saasalerts.com/mspradio/ 

There's designer clothes, but they have nothing on designer dogs!They come in a huge range of shapes and colours and sizes, from the tiny Chihuahua to the Great Dane.In the animal world this much variation usually means different species, but not for dogs — so where did they all come from?And what role did Victorian-era rats play in the development of 'breed standards'?Featuring:Joyce Sullivan, papillon breederWayne Douglas OAM, Afghan Hound breederEsther Joseph, all breeds judgeMichael Worboys emeritus professor the University of ManchesterProfessor Greger Larson, evolutionary genomics at the University of OxfordDr Angela Perri, zooarchaeologist, Chronicle HeritageDr. Elaine Ostrander, geneticist at National Institutes of Health (US)Dr Heidi Parker, geneticist at National Institutes of Health (US)Further reading:Canine Genomics and Genetics: Running with the PackThe invention of the basset hound: breed, blood and the late Victorian dog fancyProduction:Ann Jones, Presenter / ProducerNat Tencic, ProducerRebecca McLaren, ProducerPetria Ladgrove, Executive ProducerThis episode of What the Duck?! was originally broadcast in May and was produced on the land of the Wadawarrung, Wurundjeri Woi-wurrung and Taungurung people.Find more episodes of the ABC podcast, What the Duck?! with the always curious Dr Ann Jones exploring the mysteries of nature on the ABC Listen app (Australia) or wherever you get your podcasts. You'll learn more about the weird and unusual aspects of our natural world in a quirky, fun way with easy to understand science.

Depression, also known as major depressive disorder, is projected to be the number 1 cause of disease burden by 2030. We look at the causes and risk factors, the DSM 5 diagnostic criteria, and the treatment of depression.PDFs available here: https://rhesusmedicine.com/pages/psychiatryConsider subscribing (if you found any of the info useful!): https://www.youtube.com/channel/UCRks8wB6vgz0E7buP0L_5RQ?sub_confirmation=1Patreon: https://www.patreon.com/rhesusmedicineBuy Us A Coffee!: https://www.buymeacoffee.com/rhesusmedicineTimestamps:0:00 Major Depressive Disorder0:23 DSM 5 Criteria - Major Depressive Disorder 1:58 Depression Causes & Risk Factors 3:10 Depression Pathophysiology 4:28 Depression Epidemiology 4:59 Depression Diagnosis 5:39 Depression Treatment LINK TO SOCIAL MEDIA: https://www.instagram.com/rhesusmedicine/Reference:Bains, N. & Abdijadid, S., 2023. Major Depressive Disorder. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing. [online] Available at: https://www.ncbi.nlm.nih.gov/books/NBK559078/. NCBIPsycom, 2025. DSM-5 depression criteria – Major Depressive Disorder. [online] Available at: https://www.psycom.net/depression/major-depressive-disorder/dsm-5-depression-criteria.Wikipedia, 2025. Major depressive disorder. [online] Available at: https://en.wikipedia.org/wiki/Major_depressive_disorder.National Institute of Mental Health (NIMH), 2025. Depression. [online] Available at: https://www.nimh.nih.gov/health/topics/depression.Bondy, B., 2002. Pathophysiology of depression and mechanisms of treatment. Dialogues in Clinical Neuroscience, 4(1), pp.7–20. [online] Available at: https://www.tandfonline.com/doi/full/10.31887/DCNS.2002.4.1/bbondy. Taylor & Francis OnlineDisclaimer: Please remember this podcast and all content from Rhesus Medicine is for educational and entertainment purposes only and is not a guide to diagnose or to treat any form of condition. The content is not to be used to guide clinical practice and is not medical advice. Please consult a healthcare professional for medical advice.

Send us a textDr. Edward Holland is a world-renowned leader in corneal transplantation and severe ocular surface disease, and is the Co-Founder of the Holland Foundation for Sight Restoration ( HFSR - https://www.hollandfoundationforsight.org/ ) is a 501(c)(3) nonprofit organization, dedicated to transforming the lives of individuals affected by these conditions, including limbal stem cell deficiency (LSCD) – a rare and devastating condition that can result in chronic pain, profound vision loss, and blindness.Through this HFSR initiative, Centers of Excellence (COEs) focused on the advanced sight restoration procedures of Ocular Surface Stem Cell Transplantation (OSST) are being launched across the country. As part of its mission, the foundation is also committed to broadening education and training so that more physicians nationwide can learn and implement The Cincinnati ProtocolTM for the management of these patients.Dr. Holland is also the Director of Cornea Services at Cincinnati Eye Institute ( https://www.cincinnatieye.com/doctors/edward-j-holland-m-d/ ) and Professor of Ophthalmology at the University of Cincinnati ( https://med.uc.edu/landing-pages/profile/Index/Pubs/hollanej ). Dr. Holland attended the Loyola-Stritch School of Medicine in Chicago and trained in Ophthalmology at the University of Minnesota.  He completed a fellowship in cornea and external disease at the University of Iowa and then completed a second fellowship in ocular immunology at the National Eye Institute, National Institutes of Health in Bethesda, Maryland. Dr. Holland formerly served as the President for the American Society of Cataract and Refractive Surgery and served as the Program Chair for 12 years.  Dr. Holland was a former member of the Board of Trustees for the American Academy of Ophthalmology and served as the Secretariat of the Annual Meeting.  Dr. Holland has served as the Chair of the Eye Bank Association and was the former Chair of the Medical Advisory Board as well as a longtime member of the Board of Directors.  Robert Dempsey, MBA is also a Co-Founder of the Holland Foundation for Sight Restoration.Mr. Dempsey brings more than two decades of domestic and global experience in the ophthalmic space driving successful drug development, business transactions and commercialization. His widespread experience in Ophthalmology stems from diverse Leadership roles across Commercial, Business Development, Medical Affairs and Venture Backed Startups. He brings deep relationships with Key Opinion Leaders and comprehensive knowledge of the ophthalmic ecosystem. Most recently, Mr. Dempsey served as the Chief Executive Officer for AsclepiX Therapeutics, following his CEO role at TearClear accelerating business and commercial strategies which led to several value inflection points and positive FDA engagements. Mr. Dempsey holds a Master's in Business Administration and a Bachelor of Science in healthcare marketing from Northeastern University in Boston, Massachusetts.Important Episode Link - Holland Foundation for Sight Restoration Launches Light After Darkness Fundraising Campaign - https://www.globenewswire.com/news-release/2025/10/22/3171067/0/en/Holland-Foundation-for-Sight-Restoration-Launches-Light-After-Darkness-Fundraising-Campaign.html#EdwardHolland #RobertDempsey #HollandFoundationForSightRestoration #OcularSurfaceStemCellTransplantation #Ophthalmology #LightAfterDarkness #Cornea #LimbalStemCell #ProgressPotentialAndPossibilities #IraPastor #Podcast #Podcaster #STEM #Innovation #Technology #Science #ResearchSupport the show

My conversation with Dr Emanuel begins at about 34 minutes Subscribe and Watch Interviews LIVE : On YOUTUBE.com/StandUpWithPete ON SubstackStandUpWithPete Stand Up is a daily podcast. I book,host,edit, post and promote new episodes with brilliant guests every day. This show is Ad free and fully supported by listeners like you! Please subscribe now for as little as 5$ and gain access to a community of over 750 awesome, curious, kind, funny, brilliant, generous soul In Eat Your Ice Cream, renowned health expert Dr. Ezekiel J. Emanuel argues that life is not a competition to live the longest, and that "wellness" shouldn't be difficult; it should be an invisible part of one's lifestyle that yields maximum health benefits with the least work Ezekiel J. Emanuel, MD, PhD, is the Vice Provost for Global Initiatives, the Co-Director of the Healthcare Transformation Institute, and the Diane v.S. Levy and Robert M. Levy University Professor at the University of Pennsylvania Perelman School of Medicine. Emanuel is an oncologist and world leader in health policy and bioethics. He is a Special Advisor to the Director General of the World Health Organization, Senior Fellow at the Center for American Progress, and member of the Council on Foreign Relations.  He was the founding chair of the Department of Bioethics at the National Institutes of Health and held that position until August of 2011. From 2009 to 2011, he served as a Special Advisor on Health Policy to the Director of the Office of Management and Budget and National Economic Council. In this role, he was instrumental in drafting the Affordable Care Act (ACA). Emanuel also served on the Biden-Harris Transition Covid Advisory Board. Dr. Emanuel is the most widely cited bioethicist in history.  He has over 350 publications and has authored or edited 15 books. His recent publications include the books Which Country Has the World's Best Health Care (2020), Prescription for the Future (2017), Reinventing American Health Care: How the Affordable Care Act Will Improve our Terribly Complex, Blatantly Unjust, Outrageously Expensive, Grossly Inefficient, Error Prone System (2014) and Brothers Emanuel: A Memoir of an American Family (2013). In 2008, he published Healthcare, Guaranteed: A Simple, Secure Solution for America, which included his own recommendations for health care reform. Dr. Emanuel regularly contributes to the New York Times, the Washington Post, the Wall Street Journal, The Atlantic, and often appears on BBC, NPR, CNN, MSNBC and other media outlets. He has received numerous awards including election to the National Academy of Medicine, the American Academy of Arts and Sciences, the Association of American Physicians, and the Royal College of Medicine (UK). He has been named a Dan David Prize Laureate in Bioethics, and is a recipient of the AMA-Burroughs Wellcome Leadership Award, the Public Service Award from the American Society of Clinical Oncology, Lifetime Achievement Award from the American Society of Bioethics and Humanities, the Robert Wood Johnson Foundation David E. Rogers Award, President's Medal for Social Justice Roosevelt University, and the John Mendelsohn Award from the MD Anderson Cancer Center. Dr. Emanuel has received honorary degrees from Icahn School of Medicine at Mount Sinai, Union Graduate College, the Medical College of Wisconsin, and Macalester College. In 2023, he became a Guggenheim Fellow. Dr. Emanuel is a graduate of Amherst College. He holds a M.Sc. from Oxford University in Biochemistry, and received his M.D. from Harvard Medical School and his Ph.D. in political philosophy from Harvard University. On YOUTUBE.com/StandUpWithPete ON SubstackStandUpWithPete   Listen rate and review on Apple Podcasts Listen rate and review on Spotify Pete On Instagram Pete on Blue Sky Pete on Threads Pete on Tik Tok Pete on Twitter Pete Personal FB page Stand Up with Pete FB page All things Jon Carroll  Gift a Subscription https://www.patreon.com/PeteDominick/gift Send Pete $ Directly on Venmo  

There's a new recruitment opportunity at Health and Human Services. The agency has just launched the Roy Wilkins Fellowship. It's reserved for students at Historically Black Colleges and Universities, or HBCUs, who are interested in public service. Many of HHS's divisions will host career fairs to promote the new fellowship, including the National Institutes of Health and the Centers for Disease Control and Prevention. The opportunity comes in response to an executive order President Trump signed in April, on promoting innovation at HBCU's. See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

There goes my baby. . . to sleep with this soothing white noise sound! You don't know how good it feels to. . . calm your crying infant. Parents, you deserve a break! This 8 hour white noise track will help soothe a crying baby. Use it to both calm a colicky infant and help with nighttime sleeping. White noise resembles sounds the baby heard in the womb, which has a calming effect. It also masks other distracting noises so that your baby can fall asleep and remain sleeping. While playing white noise for babies, it's important to keep tabs on the volume, because any white noise machine, smartphone, or computer can put out levels that are too loud for your child. It's recommended to play the sound at least a few feet from where your infant is sleeping and to keep the volume no louder than the sound of a soft shower.  Parents can download an app to turn their smartphone into a sound level meter. One good, free, option is the sound level meter app created by the U.S. National Institutes for Occupational Safety and Health (NIOSH) available on the app store as the NIOSH SLM app.Here are some great products to help you sleep! Relaxing White Noise receives a small commission (at no additional cost to you) on purchases made through affiliate links. Thanks for supporting the podcast!⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠Baloo Living Weighted Blankets⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ (Use code 'relaxingwhitenoise10' for 10% off)At Relaxing White Noise, our goal is to help you sleep well. This episode is eight hours long with no advertisements in the middle, so you can use it as a sleeping sound throughout the night. Listening to our white noise sounds via the podcast gives you the freedom to lock your phone at night, keeping your bedroom dark as you fall asleep. It also allows you to switch between apps while studying or working with no interruption in the ambient sound.⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠Check out the 10-Hour version on YouTube⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠Contact Us for Partnership Inquiries⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠Relaxing White Noise is the number one destination on YouTube for white noise and nature sounds to help you sleep, study or soothe a baby. With more than a billion views across YouTube and other platforms, we are excited to now share our popular ambient tracks on the Relaxing White Noise podcast. People use white noise for sleeping, focus, sound masking or relaxation. We couldn't be happier to help folks live better lives. This podcast has the sound for you whether you use white noise for studying, to soothe a colicky baby, to fall asleep or for simply enjoying a peaceful moment. No need to buy a white noise machine when you can listen to these sounds for free. Cheers to living your best life!DISCLAIMER: Remember that loud sounds can potentially damage your hearing. When playing one of our ambiences, if you cannot have a conversation over the sound without raising your voice, the sound may be too loud for your ears. Please do not place speakers right next to a baby's ears. If you have difficulty hearing or hear ringing in your ears, please immediately discontinue listening to the white noise sounds and consult an audiologist or your physician. The sounds provided by Relaxing White Noise are for entertainment purposes only and are not a treatment for sleep disorders or tinnitus. If you have significant difficulty sleeping on a regular basis, experience fitful/restless sleep, or feel tired during the day, please consult your physician.⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠Relaxing White Noise Privacy Policy⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠© Relaxing White Noise LLC, 2025. All rights reserved. Any reproduction or republication of all or part of this text/visual/audio is prohibited.

It is not an understatement to say that AI has revolutionized virtually every aspect of human life. What should characterize a Christian posture towards AI? Should we be concerned? Optimistic? How do we think biblically about it the emergence of new AI technology? In this unique episode, Sean is joined by three Biola/Talbot professors who are experts in their fields and in AI: Yohan Lee, Associate Dean of Technology and Professor of Computer Science; Michael Arena, Dean of Biola's Crowell School of Business; and Mihretu Guta, Professor of Philosophy and Apologetics. Mihretu P. Guta, Ph.D. (Philosophy at Durham University, UK). After completing his Ph.D., he worked as a Postdoctoral Research Fellow at Durham University within the Durham Emergence Project which was set up with cooperation between physicists and philosophers and funded by the John Templeton Foundation. Guta's postdoctoral research focused on the nature of the emergence of the phenomenal consciousness taken from the standpoint of metaphysics, philosophy of mind, cognitive neuroscience and quantum physics. Dr. Yohan Lee has led advanced technology organizations for over 20 years in commercial industry, education, and government. He has been privileged to serve as a civil scientist (U.S. National Institutes of Health), Principal Investigator (Google AI), Chief Science Officer (Riiid Labs, Inc.), and CEO (Scaled Entelechy, Inc). His undergraduate and doctoral studies were at UCLA in neuroscience and genomics with a focus on the neurological basis of learning and memory in addition to precision medicine. His doctoral work centered on large scale genomic data for health and distributed computing. In his corporate role, Dr. Lee has led research and business units in industry, public-private partnerships, the federal government, and international academic consortia for enterprise initiatives with Fortune 50 corporations. Michael Arena, Ph.D., is the dean of the Crowell School of Business at Biola University. He is also the chief science officer and co-founder of the Connected Commons, a research consortium that brings together business and academic thought leaders to develop and apply organizational network solutions. Prior to joining Biola, he served as the vice president of talent and development at Amazon Web Services (AWS), where he leveraged network analysis to enable employee growth, organizational culture and innovation. Arena was also the chief talent officer for General Motors Corporation where he helped to facilitate a business transformation, which is highlighted in his book Adaptive Space. Arena also spent two years as a visiting scientist with MIT's Media Lab researching human networks and acted as a design thinking coach within the Stanford School for three years. ==========Think Biblically: Conversations on Faith and Culture is a podcast from Talbot School of Theology at Biola University, which offers degrees both online and on campus in Southern California. Find all episodes of Think Biblically at: https://www.biola.edu/think-biblically. To submit comments, ask questions, or make suggestions on issues you'd like us to cover or guests you'd like us to have on the podcast, email us at thinkbiblically@biola.edu.

A crisis doesn't have to break your church or organization. In this powerful conversation, Dr. Mark Rutland, Executive Director of the National Institute of Leadership and founder of Global Servants, joins Phil Cooke https://philcooke.com to share hard-earned insights on leading through crisis, turnaround leadership, and building a lasting leadership legacy. Drawing from firsthand experience in crisis management at Southeastern University, Calvary Church, and Oral Roberts University, Dr. Rutland explains why crisis isn't always about scandal—and why vision, systems analysis, and truth-telling are essential for renewal and growth.

The House on Monday passed a bill that would revamp how agencies purchase software, putting the legislation in the same place it was a year ago: waiting for the Senate to follow suit as the clock ticks down on the congressional calendar. The Strengthening Agency Management and Oversight of Software Assets (SAMOSA) Act would require agencies to examine their software licensing practices, with the aim of streamlining IT buying practices to avoid duplicative purchases. The bill is identical to legislation that passed the House last December but did not move forward in the Senate. The House bill, co-sponsored by Reps. Nancy Mace, R-S.C., Shontel Brown, D-Ohio, Pat Fallon, R-Texas, and April McClain Delaney, D-Md., would press agencies to better manage their software without limiting procurement options. They would be required to submit IT assessments to the Office of Management and Budget, the General Services Administration and Congress, so better oversight could be conducted. On the House floor Monday, Brown credited her three co-sponsors as well as former Rep. Gerry Connolly, D-Va., who died of cancer in May after taking the lead on this bill in addition to his myriad other government IT efforts. Brown, ranking member of the House Oversight Cybersecurity, Information Technology, and Government Innovation subcommittee, said the SAMOSA Act is a “straightforward good government bill that has strong bipartisan support from members of the Oversight Committee.” A new bill from Sens. John Fetterman, D-Pa., and Ted Budd, R-N.C., would establish a national network of cloud laboratories led by the National Science Foundation and supported by the National Institute of Standards and Technology, with the goal of enhancing collaboration between institutions while improving research efficiency with AI. If passed, NSF will select up to six programmable cloud laboratories from a range of applicants, including academic institutions and private-sector research groups. NIST would be tasked with setting standards and reporting to Congress about the feasibility for expansion. The bill, introduced last week, aligns with provisions laid out by the Trump administration's AI Action Plan and aims to codify existing NSF proposals, according to the sponsors. NSF earmarked $100 million for a similar AI-powered cloud network in August as it looked to expand access to emerging technologies. Researchers in the co-sponsors' home states have developed methods to ease automated discoveries, which will serve as a blueprint for the national effort. NSF will judge applicants on the level of existing data integration and automated capability infrastructure and capacity to support multi-user cloud workflows, among other criteria. In addition to bipartisan backing, the legislation garnered support from officials at Carnegie Mellon University, the Accelerate Science Now coalition and the Allegheny Conference on Community Development. The Daily Scoop Podcast is available every Monday-Friday afternoon. If you want to hear more of the latest from Washington, subscribe to The Daily Scoop Podcast  on Apple Podcasts, Soundcloud, Spotify and YouTube.

Co-hosts Ryan Piansky, a graduate student and patient advocate living with eosinophilic esophagitis (EoE) and eosinophilic asthma, and Holly Knotowicz, a speech-language pathologist living with EoE who serves on APFED's Health Sciences Advisory Council, interview Fei Li Kuang, MD, PhD, an allergist and immunologist, at Northwestern Medicine, about receiving two APFED HOPE on the Horizon Grants. Disclaimer: The information provided in this podcast is designed to support, not replace, the relationship between listeners and their healthcare providers. Opinions, information, and recommendations shared in this podcast are not a substitute for medical advice. Decisions related to medical care should be made with your healthcare provider. Opinions and views of guests and co-hosts are their own.   Key Takeaways: [:50] Co-host Ryan Piansky introduces this episode, brought to you thanks to the support of Education Partners GSK, Sanofi, Regeneron, and Takeda. Ryan introduces co-host Holly Knotowicz.   [1:14] Holly introduces today's topic, two APFED HOPE on the Horizon Pilot Grant Projects and today's guest, Fei Li Kuang, MD, PhD, an Assistant Professor in the Division of Allergy and Immunology at Northwestern University Feinberg School of Medicine in Chicago, Illinois.   [1:42] Dr. Kuang is a physician-scientist who takes care of patients with eosinophilic disorders and also performs laboratory research on these disorders in her lab, often using patient samples. Holly thanks Dr. Kuang for joining us.   [2:05] As a child, Dr. Kuang always wanted to be a scientist. She is so grateful to live out her childhood dream, and it's because of the amazing people who have supported her, most importantly, her parents.   [2:29] In graduate school, Dr. Kuang studied B cells. When she went on to do an allergy fellowship, she thought she would study B cells and care for patients with B cell problems. Instead, she fell in love with allergy and eosinophilic disorders.   [2:50] Dr. Kuang is here, in part, because of the different mentors she has had, and in large part, because of the patients she has met along the way.   [3:20] Dr. Kuang had the opportunity to work with Amy Klion at the NIH in a clinical trial to treat patients with a drug that gets rid of eosinophils. She says it was a dream come true after her training.   [4:02] She says she learned so much about eosinophils, their unusual biology, and the mystery behind what they are here for. She got hooked.   [4:15] Dr. Kuang thinks the patients you meet in a clinical trial in a special place like NIH occupy a space in your heart that makes you want to keep working on the subject area.   [4:34] Patients in a clinical trial have given up a bunch of their time to travel to Bethesda, Maryland. For the trial Dr. Kuang participated in as a Fellow, it was a good year of their time to come out and do it.   [4:47] Dr. Kuang felt there were so many interesting questions, from an intellectual point of view, but there was also a real need from patients with chronic conditions. It was a beautiful opportunity to marry scientists with physicians in training.   [5:36] Dr. Kuang shares some knowledge about eosinophils. They are white blood cells that are in all of us. They have little pink packages or granules that "jumped out" in the light microscope almost 200 years ago, when we first identified them.   [6:00] Dr. Kuang says that animals, dating back to reptiles, and different species of dolphins, all have eosinophils. A veterinary scientist, Dr. Nicole Stacy of the University of Florida, has taken photos of eosinophils from all these different species.   [6:21] They've been around for a long time. What are they good for? What we know is that they are associated with disease conditions, such as asthma and others, including leukemia. Those were the classic first studies of eosinophils.   [6:42] Now, we have a different mindset about eosinophils from work by the late James Lee at Mayo Clinic, Arizona.   [6:58] Dr. Kuang credits Dr. Lee with suggesting that eosinophils not just cause us problems but also help treat parasitic infections, maintain tissue homeostasis, help wound healing, and tissue repair. That's a new area we are beginning to appreciate.   [7:41] Dr. Kuang says we need to be open-minded that in some circumstances, eosinophils may be helpful or innocent. Now we have tools to start to understand some of that. We need to collect information from patients being treated with medicines.   [8:10] Ryan tells of being diagnosed as a kid. Doctors explained to him that eosinophils fight parasites, but in some people, they get confused and attack the esophagus. That's EoE. That was easy to understand, but he knew that the researchers knew more.   [8:53] Ryan is grateful to the patient population around eosinophilic esophagitis, and is proud of APFED's support of patients and caregivers with HOPE Grants. APFED has the HOPE on the Horizon Research Program, entirely funded by community donations.   [9:13] To date, APFED has directed more than $2 million toward eosinophilic disease research initiatives through various grant programs. As a patient advocacy organization, APFED works with fantastic researchers who submit innovative research ideas.   [9:32] These research ideas go through an extensive and competitive peer-review process, supported by researchers and clinicians in the APFED community.   [9:42] Today, we're going to discuss two different projects supported by HOPE Pilot Grants with Dr. Kuang.   [10:00] Dr. Kuang thinks there are two ways these grant programs are important to patients. One is advancing research by nurturing seedling investigators. Dr. Kuang got her first grant when she was a Fellow. It was an incredible opportunity.   [10:25] These grant programs also nurture seedling ideas that don't have enough evidence yet to garner the larger NIH grants, and so forth. There are other sources for grants: pharmaceutical companies. The grant programs are for seeds.   [10:49] Patients need to know that there are new things that are given some chance of being tested out. Research takes some time, and the FDA process of getting a drug approved is long.   [11:04] For the newly diagnosed patient, it can feel overwhelming. It feels like there's a loss of control. Sometimes, participating in something like APFED, being part of a community, gives back a sense of control that is lost when you're handed a diagnosis.   [11:45] For patients who have had it for a long time, when they participate in research and become engaged in organizations like APFED, they know they may not directly benefit today, they may benefit later, but they hope future patients will benefit.   [12:21] That gives them a sense of control and hope that things will be better for the next generation. We all want that, especially in medicine, in something that we don't have a very deep understanding of.   [12:58] Dr. Kuang received two HOPE Pilot Grants, one in 2018 and one in 2022. The first grant was awarded when she was a Fellow at the NIH.   [13:05] That first grant explored some effects of eosinophilic depletion of pathogenic lymphocytes in hypereosinophilic syndrome and overlaps with EGIDs. Ryan asks for a broad overview of that research.   [13:25] When Dr. Kuang was a Fellow at the NIH, they were doing a Phase 2 clinical trial, looking at "blowing up" eosinophils in patients who have a lot of them, hypereosinophilic syndrome patients.   [13:39] They included patients who had eosinophilic GI disease, often beyond the esophagus. They may have esophageal involvement, but sometimes their stomach is impacted, sometimes their large bowel is impacted, with related symptoms.   [13:57] What Dr. Kuang and the team noticed in the trial was that just within that little group of patients, there were people who did well, and people who did much better than before, but would have recurrent symptoms, and with no eosinophils in their GI tissues.    [14:16] The researchers wanted to know what was causing these problems for the patient. If you take eosinophils away, what other factors will impact the immune system of the patient, semi-long-term?   [14:32] Their focus was on these groups of patients who had different responses. They looked at the white blood cells that had been previously described as being the responsible, "bad" T cells that lead to eosinophils in the gut.   [14:49] They found that the patients who had recurrent flares of the disease had more of the bad T cells, and the patients who responded well and never complained again about symptoms did not.   [15:03] That allowed researchers to identify that there were subsets of patients with the disease that they were calling the same thing.   [15:18] Dr. Kuang says that work also led them to find that those cells were being reported in patients who had food allergies for which they needed an epinephrine auto-injector.   [15:27] The researchers were curious whether that was just a food allergy issue, or only applied if you had food allergies and eosinophilic GI disease. That HOPE project allowed them to do a pilot study to look at food allergy patients, too. They did, and published it.   [15:45] They published that in patients who have a food allergy and have these T cells, the insides of those cells make different messages for the immune system than the ones that the researchers had previously described.   [16:01] In looking for why there were differences in those responses, they accidentally found that there were differences inside these cells in a completely different disease, which also had these T cells.   [16:21] Dr. Kuang says that the finding was kind of a surprise. If they had found anything in the eosinophilic GI disease patients, that would have been good. They also looked at the epithelial cells and the structure of the GI lining.   [16:42] Even though there were no eosinophils in the GI lining in the patients who had been treated with a biologic that depleted eosinophils, their GI lining still looked like the GI lining of patients who had eosinophilic GI disease.   [16:55] Dr. Kuang asked what was creating those spots. Our gut lining sheds, so there should have been an opportunity for the GI lining to turn over and look new. Something was there, making signals to create these spots. They did a different publication on that.   [17:21] The data from the HOPE Pilot study allowed Dr. Kuang to apply for larger grants. It allowed her to propose to the company that made this drug, when they did the Phase 3 trial, to insert into that special study the study on eosinophilic GI disease.   [17:48] Do patients with eosinophilic GI disease do better or worse on this drug, and how do the T cells look in that trial? That HOPE Grant gave Dr. Kuang the data to ask the drug company to give her money to study it in an international cohort of patients.   [18:17] There were only 20 patients in that first NIH trial, who gave a year of their life, coming to NIH all the time. They continued to be in the study until the drug was approved for asthma.   [18:28] Dr. Kuang says the main reason the company did the Phase 3 trial, which is expensive, and the market share is not huge because it's a rare disease, is that two of the patients went to bat for this disease population.   [18:47] The two patients went and showed the business people what they looked like before, what the drug had done for them, and how their lives had changed. It wasn't the doctors or the great paper from the trial, but the patients who convinced the company.   [19:01] Dr. Kuang says she was so floored by that and moved by what they did for the community. She is grateful.   [19:24] Since the Phase 3 trial, Dr. Kuang and the other researchers realized they had not fully studied the eosinophils. They had studied them in part. They found differences in response. This inspired the second APFED HOPE Pilot Grant.   [21:19] In 2022, Dr. Kuang received a two-year APFED HOPE Pilot Grant to examine how blood eosinophils in Eosinophilic Gastrointestinal Diseases differ from those of other eosinophilic diseases and how T cells in EGIDs differ from those in food allergies.   [21:49] Dr. Kuang says normally, the biggest place of residence for eosinophils is the GI tract. That's where they are normally seen in people who do not have eosinophilic disorders.   [21:59] People who have eosinophilic disorders that attack other parts of the body, asthma, and rarely, the heart. Dr. Kuang was curious to know why one person and not the other?   [22:15] Patients who have eosinophilic GI disease often ask, How do you know this high level in the blood is not going to attack my heart or my lungs in the future? Dr. Kuang does not know.   [22:29] Dr. Kuang says, looking at the cohort at the NIH, that for many patients who have both GI organ involvement and some other space, when they first went to see a provider, their first complaint was a GI condition.   [22:54] If the doctor had only diagnosed a GI condition, nothing else, that would have been wrong. Those patients may not have been monitored as well. A third of the patients originally presented like that.   [23:11] What that meant was that we should be paying attention to patients who have GI disease who have lots of eosinophils in their blood. Moving forward, if there are new complaints, we need to investigate. We can't forget they have that.   [23:27] Dr. Kuang asks, Wouldn't it be great if we had a better tool than needing to wait? Wouldn't it be great if we had a biomarker that said the eosinophils have switched their target location and are going somewhere else?   [23:41] One way to do that is to take different groups of eosinophils and look for differences between those that never target the GI tract and those that do. In patients who have EoE, the eosinophils only target or cause problems in the esophagus.   [23:58] Are their eosinophils any different than those of a healthy person, with none of these conditions? That was the goal of that study.   [24:10] T cells are another type of white blood cell. They contain a memory of foreign things they have encountered, which allows them to glom onto flu, COVID, peanuts, pollen, that kind of thing. They remember.   [24:32] Dr. Kuang says they learned that T cells, at least in the mouse model, are required in the development of eosinophilic esophagitis. The mice in the old study, where mice were forced to develop EoE, did not get EoE if you removed their T cells.   [24:50] In the first APFED HOPE grant study, Dr. Kuang found T cells in the blood and tissue of both EGIDs and food allergy patients, but the insides of the T cells were different. The food allergy patients were children recruited by a pediatric allergist.   [25:19] In the second APFED HOPE grant study, at Northwestern, Dr. Kuang recruited her adult food allergy patients. That was a way to validate what they found in the first study and move further to better characterize those T cells in the two different diseases.   [25:47] Dr. Kuang says we're at a point where we've recruited a lot of people. She says it's amazing what people are willing to do. It's very humbling.   [26:06] Dr. Kuang's team in the lab is really great, too. To accommodate patients, they would see them after work, if that's what they had to do to isolate eosinophils. So they did that, and now they are in the process of analyzing that data. It's really exciting.   [26:28] What's exciting is that they are seeing results that show that eosinophilic GI disease patients have circulating eosinophils that are different from the eosinophils of people who don't have GI involvement, and from people who have EoE.   [26:46] The EoE patients have eosinophils different from those of healthy donors. Dr. Kuang says there's a lot of promise for perhaps unique signatures that could help define these conditions; maybe someday without biopsying, but that's a long time away.   [27:16] Dr. Kuang says they will focus on some candidate targets and try to recreate some of that in a dish with eosinophils from healthy people.   [27:26] What are the signals that lead eosinophils to do this, and can we translate that back to available drugs that target certain cytokines or other pathways, and maybe give some insight to develop drugs that target other pathways for these diseases?   [28:17] Ryan thinks it's exciting that this research is narrowing in on not only the different symptoms, but also how the eosinophils are acting differently in these populations.    [28:44] Dr. Kuang is super excited about this research. You could imagine that all eosinophils are the same, but you don't know until you look. When they looked, using the newest technology, they found there were differences.   [29:33] Dr. Kuang says it is thought that T cells respond to triggers. We don't think eosinophils have a memory for antigens. T cells do. That's one of their definitions. When T cells react to a trigger, they give out messages through cytokines or by delivery.   [30:20] Those are the messages that recruit eosinophils and other cells to come and stir up some trouble.   [30:28] In the mouse model, where you don't have the T cells, and you don't get eosinophilic esophagitis in the particular way they made it happen in a mouse, that middle messenger is gone, so the eosinophils don't know where to go.   [30:44] With drugs that take out eosinophils, you think that you've gotten rid of the cell that creates all the problems. It shouldn't matter what the message says because there's no cell there to cause the damage.   [30:58] What Dr. Kuang learned is that, at least in certain eosinophilic GI diseases, that's not true. You erase the eosinophils from the picture, but that message is still coming.   [31:10] Who's carrying out the orders? Or is that message maintaining the wall of epithelial cells in a certain way that we didn't appreciate because the eosinophils were also there?   [31:24] It's important to study both, because one is the messenger and the other is one of the actors. Whether all of the actions taken by eosinophils are bad, or maybe some of them were meant to be good, we have yet to learn.   [31:40] At the moment, we're using it as a marker for disease activity, and that may change in the future, as we learn more about the roles of these cells in the process.   [31:50] We have drugs now that target eosinophils and drugs that target T cells. Dr. Kuang thinks it's important to study both and to study the impact of these drugs on these cells.   [32:02] You could theoretically use these drugs to understand whether, if someone responds to it, what happens to these cells, and if someone doesn't respond to it, what happens to these cells, and how this disease manifests in this flavor of patients.   [32:54] Dr. Kuang says, Often in science, we take a model. We think this works this way. Then, if this works this way, we expect that if we remove this, these things should happen. We did that with the first clinical trial, with NIH patients.   [33:10] It didn't quite happen the way we thought, so we had to go looking for explanations. These were unusual setbacks. Sometimes you have unusual findings, like the food allergy part.   [33:24] When Dr. Kuang went to Northwestern, she saw different cohorts of patients than she saw at NIH. She saw people who were seen every day, which is a different spectrum than those who are selected to be enrolled in a study protocol at the NIH.   [33:42] That broadened her viewpoint. It's maybe not all food-triggered. They were seeing adults who'd never had food allergies or asthma their whole life, and they had eosinophilic esophagitis suddenly as a 50-year-old. There's a significant group of them.   [34:10] What Dr. Kuang learned and tries to be open-minded about is that where you train, what sorts of patients you see, really shape your viewpoint and thinking about the disease process and the management process.   [34:24] Dr. Kuang says she was so lucky to have experienced that at a quaternary care referral center like the NIH and at an academic center like Northwestern, where there are fantastic gastroenterologists who see so many of these patients.   [34:56] Dr. Kuang and an Allergy Fellow knew they were going to get a wonderful data set from the NIH patients they had recruited, so they thought they had better look deeply at what had been learned before with older technology, with mice and people.   [35:13] They decided to gather previous research, and that ultimately got published as an article. From that research, they learned that people did things in many different ways because there was no standard. They didn't know what the standard should be.   [35:28] Different things you do to try to get eosinophils out of tissue impact how they look, in terms of transcript, gene expression, and what messages they make to define themselves as an eosinophil.   [35:43] They also learned that because eosinophils are hard to work with, they die easily, and you can't freeze them and work on them the next day; you can introduce issues in there that have to be accounted for.   [35:59] They learned that as an eosinophil research community, they ought to come up with some standards so that they can compare future studies with each other. Dr. Kuang says it was impossible to compare the old studies that used different premises.   [36:50] Dr. Kuang says we need to be proactive in creating the datasets in a standard way so that we can compare and have a more fruitful and diverse community of data. It's hard to use the old data.   [37:57] Dr. Kuang says they get fresh blood from patients, and because eosinophils are finicky, they need to be analyzed within four hours, or preserved in a way to save whatever fragile molecules are to be studied.   [38:19] If you let it sit, it starts dying, so you won't have as many of them, and they start changing because they're not in the body. Dr. Kuang experimented with putting a tube of blood on the bench and checking it with the same test every two hours. It changes.   [38:38] Four hours is a standard to prevent the eosinophils from dying. Patients need treatment. If a patient is hospitalized and needs treatment, Dr. Kuang's team needs to be there to get a sample before treatment is started.   [39:03] The treatment impacts it, changing the situation. Much of the treatment, initially, is steroids. When you give lots of steroids, the eosinophils go away. It's no good to draw their blood then.   [39:27] Dr. Kuang also gets a urine sample. The granules of the eosinophils can get into the urine. As they study people with active disease, they want to capture granule proteins in the urine as a less invasive way to monitor activity in different disease states.   [40:04] The patient just needs to give Dr. Kuang either arm and a urine sample.   [41:04] Dr. Kuang explains, you can count your eosinophils after four hours, but to study them, they have different flags of different colors and shapes. Those colors and shapes may mean that it's an activated eosinophil, or they may have other meanings.   [41:41] Dr. Kuang focused on markers that look at whether it's going to spill its granules and some traditional markers of activation.     [41:50] Everyone chooses a different marker of activation. So they decided to look at as many as they could. One marker is not sufficient. They seem to be different in different conditions. The markers are on the surface; you need to analyze them right away.   [42:20] Then, Dr. Kuang breaks open the eosinophils and grabs the messenger RNA. They preserve it to do sequencing to read out the orders to see what this eosinophil is telling itself to make. RNA chops up messages.   [43:00] When you open an eosinophil, a protein you find is RNA, which chops up messages, destroying parts of the cell. You want to save the message. There's a brief time to analyze the eosinophil. Dr. Kuang works to preserve and read the message.   [44:04] Dr. Kuang hopes someday to run a tube of blood, look at the flags on the eosinophils, and say, "I think your eosinophilic GI disease is active," or "You have a kind of eosinophilic GI disease we need to monitor more frequently for organ damage."   [44:38] If another patient doesn't have those flags, Dr. Kuang could say, "I think the chances that you're going to have involvement elsewhere are low." That can give reassurance to folks who are worried.   [45:15] Dr. Kuang hopes that someday we can understand better why some people have food allergies vs. eosinophilic GI disease. They both have T cells, but the T cells have different packages inside with messages to deliver.   [45:34] Every day, Dr. Kuang has to tell patients she doesn't have that answer. Someday, she hopes she can tell a patient she does have that answer.   [46:35] Dr. Kuang tells about an NIH grant she's excited about and the patients she recruits after therapy, or elimination diets, to examine eosinophils and T cells, to see the impacts their treatments or diets have had on eosinophilic GI disease.   [47:18] Dr. Kuang believes there will be predictors of who will respond to an elimination diet and who will respond to steroid therapy. She hopes one day to have that, rather than going through rounds of six to eight weeks followed by a scope.   [47:34] If you have an elimination diet for six to eight weeks, every time you add back a food, you have to do a scope. Dr. Kuang says it would be great if you could be more precise ahead of time for therapy.   [47:48] Dr. Kuang says these wonderful drugs selectively take out parts of the pathway in the immune system. They provide real-life opportunities to ask, why is this important in human biology and the human immune system?   [48:15] Dr. Kuang finds the knowledge itself fascinating and useful. She hopes it informs how we choose future drugs or therapeutic avenues to get the best we can out of what we've learned, so we have more targeted ways of treating specific diseases.   [48:48] Ryan is grateful for all the research happening for the eosinophilic disease community and all the patients participating in the research. He asks Dr. Kuang how a patient can participate in research.   [49:12] There are lots of ways to be involved in research. Dr. Kuang says her patients come away from participating in research feeling good about having done it.   [49:22] Answer a survey, if that's what you have bandwidth for. Where therapies are changing, being a part of a community is good for the community, for the future, but it's good for you, too. It's healing in ways that are not steroids or biologics.   [49:58] Being part of a community is healing in ways we all need when we feel alone and bewildered. You're not alone.   [50:12] There are many ways to participate: APFED, CEGIR, individual institutions, and clinical trials. They all have different amounts of involvement. It's worthwhile to participate, not only for future patients but for yourself. They're fantastic!   [50:56] Dr. Kuang talks about the privilege as a physician of working with APFED and other organizations to do this work.   [51:09] Holly thanks Dr. Kuang for sharing all of this research and exciting information.   [51:25] Dr. Kuang is excited about what her group is doing and is hopeful. Besides showing up for this disease, we have to show up for research, in general, in this country. It's a dark time for NIH research funding.   [51:55] Dr. Kuang asks the young listeners who are thinking of choosing a field to see the potential and get into it, study this, and believe that there's going to be a future with a more nurturing research environment.   [52:36] Dr. Kuang would hate to lose generations of scientists. She says that once she was a little girl who was trying to be a scientist. Her parents had no connections with scientists or doctors, but she was able to get into research, and she thinks you can, too.   [53:48] As a graduate student, Ryan has always been interested in trying to improve things, and he sees hope on the horizon. He's very grateful to the APFED community for supporting these research HOPE Pilot Grants.   [54:17] Ryan is very grateful to Dr. Kuang for joining us today.   [54:22] For our listeners who want to learn more about eosinophilic disorders, we encourage you to visit apfed.org and check out the links in the show notes.   [54:28] If you're looking to find a specialist who treats eosinophilic disorders, we encourage you to use APFED's Specialist Finder at apfed.org/specialist.   [54:37] If you'd like to connect with others impacted by eosinophilic diseases, please join APFED's online community on the Inspire Network at apfed.org/connections.   [54:57] Dr. Kuang thanks Ryan and Holly and says she enjoyed the conversation. Holly also thanks APFED's Education Partners GSK, Sanofi, Regeneron, and Takeda for supporting this episode.   Mentioned in This Episode: Fei Li Kuang, MD, PhD, Allergist and Immunologist, Northwestern Medicine   Grants and publications discussed: Apfed.org/blog/apfed-announces-2018-hope-apfed-hope-pilot-grant-recipient/ Apfed.org/blog/fei-li-kuang-hope-pilot-grant-award/  Pubmed.ncbi.nlm.nih.gov/39213186/ Pubmed.ncbi.nlm.nih.gov/37487654/   APFED on YouTube, Twitter, Facebook, Pinterest, Instagram Real Talk: Eosinophilic Diseases Podcast apfed.org/specialist apfed.org/connections apfed.org/research/clinical-trials   Education Partners: This episode of APFED's podcast is brought to you thanks to the support of GSK, Sanofi, Regeneron, and Takeda.   Tweetables:   "I think the patients that you meet in a clinical trial, especially in a special place like NIH, occupy a space in your heart — I don't mean to be all too emotional about this — that makes you want to keep working on the subject area." — Fei Li Kuang, MD, PhD   "When I was a Fellow at the NIH, we were doing a Phase 2 clinical trial, looking at, for want of a better word, "blowing up" eosinophils in patients who have a lot of them, hypereosinophilic syndrome patients." — Fei Li Kuang, MD, PhD   "We're at a point where we've recruited a lot of people. I've had patients drive from the northern part of Illinois … come down and give me blood. It's amazing what people want to do and are willing to do. It's very humbling, actually." — Fei Li Kuang, MD, PhD   "You erase the eosinophils from the picture, but that message is still coming. Who's carrying out the orders? Or is that message maintaining the wall of epithelial cells in a certain way that we didn't appreciate because the eosinophils were also there?" — Fei Li Kuang, MD, PhD   "We need to be proactive in creating the datasets in a standard way so that we can compare and have a more fruitful and diverse community of data." — Fei Li Kuang, MD, PhD   "I think it's worthwhile to participate [in a clinical trial], not only for the future people but for yourself." — Fei Li Kuang, MD, PhD   Guest Bio: Fei Li Kuang, MD, PhD, is currently an Assistant Professor in the Division of Allergy and Immunology at Northwestern University Feinberg School of Medicine in Chicago, IL. She is a graduate of the Albert Einstein College of Medicine Medical Scientist Training Program with both a PhD in Cell Biology/Immunology and an MD.  She completed her Internal Medicine Residency at Columbia University, New York Presbyterian Hospital in New York City, she did her Fellowship in Allergy and Immunology at the National Institute of Allergy and Infectious Disease (NIAID) in Bethesda, Maryland. She is a physician-scientist who takes care of patients with eosinophilic disorders and also performs laboratory research on these disorders in her lab, often using patient samples.

A version of this essay was published by news18.com at https://www.news18.com/opinion/opinion-what-the-bjp-win-in-thiruvananthapuram-may-mean-or-may-not-9774658.htmlAs a native son, I believe the BJP's 50/101 seats in the Trivandrum Corporation in the recently concluded local body elections is an interesting outcome. But it must not be taken in isolation, and one must accept that this is neither a breakthrough for the BJP in the deep south, nor a mere footnote in the CPI(M)-Congress duopoly that has been the hallmark of Kerala politics. There are a lot of local factors, but yes, perhaps there is an underlying, nascent realignment.There is anti-incumbency: there used to be, like clockwork, one term for the UDF, one term for the LDF. But now, the CPI-M has been ruling for ten years in a row, and the voters may be fed up with them. In Trivandrum, for instance, the outgoing mayor, Arya Rajendran, who is in her 20s, has a well-deserved reputation for arrogance. Tellingly, she did not campaign in 2025.But there is more.There are at least four extraordinary factors at play here: One is the vanity that Kerala politics is somehow superior to politics elsewhere in (southern) India, because, you know, it is the 100% literate state. This is far from the truth. Mere literacy, that is, knowing the syntax of written language, does not guarantee you understand the semantics, that is, the ability to think critically rather than be gaslighted. The average Kerala voter is as easily manipulated as any other.Second, regional tensions. Kerala consists of three distinct regions: northern Malabar, which was under British rule, which meant it was plundered and underdeveloped. It also is Muslim-dominated. Central Kochi, which was a moderately dynamic dynasty, and is Christian-dominated. Southern Travancore, which was under a strong dynasty (but came under the sway of the British), and is Hindu majority.Third, the erstwhile consensus around ‘secularism' is fraying: it is now increasingly seen as merely a shibboleth meant to hypnotize the Hindu community into caste-based internecine conflict and keep it a permanent underclass, with fewer rights than those of other religions. Hindus are still fighting 19th century battles in the 21st century. The shocking neglect, occasional desecration of, and outright large-scale theft from, major temples such as Sabarimala may now be turning into a bit of an issue for the lay Hindu.Fourth, after half a century of left-wing politics, it is becoming increasingly clear to the average Keralite that it is being left behind in development and prosperity. At independence, Travancore in particular was far ahead of the rest of India in key metrics like infant mortality, female literacy, and infrastructure. But anti-business socialism has led to de-industrialization, forced migration of Keralites in search of jobs, and high inflation, while other states are passing Kerala by.On top of all this, there is the rampant politicization of everything (for example, government jobs do not go to those who have high ranks in the State Public Service Commission selection exams, but to party cadres). There is a truly bizarre situation where two parties, both in the INDI Alliance all over the country (CPI-M and Congress), pretend to be rivals in Kerala, and do charades and shadow-boxing, although they do tactical voting to prevent the BJP from winning.It startles me to hear that there is a Left (CPI-M) and a Right (Congress) in Kerala, according to pundits. In reality, they are an Extreme-Left party and a Far-Left party, respectively. Indeed, even the BJP, which is spoken of as Far-Right is a Center-Left party, so severely distorted is the discourse – the median is Far-Left.To an impartial observer, the only way the Congress in Kerala can be termed a Right-wing party is that it appeases its vote-bank, the Christians, although the FC Nairs also traditionally vote for them. The Communists, whose rank and file are mostly made up of the OBC Ezhavas, increasingly are dominated by the needs of their Malabar Muslim vote-bank. So in a twisted sort of way, both these Left parties pander to the Conservative sentiments of these religious groups.This has real-life consequences, which Travancore voters are seeing increasingly clearly. The last major investment in Trivandrum was the ISRO's Vikram Sarabhai Space Center, which was required to be on the magnetic equator. After that, the National Institute of Technology went to Kozhikode (in Malabar). The Indian Institute of Management went to Kozhikode (in Malabar). The Indian Institute of Technology went to Palakkad (in Malabar). The AIIMS is also likely to go to Malabar or Kochi.A metro system was given to Kochi, even though Trivandrum has an equal or better claim in terms of population size and other metrics. Successive UDF and LDF governments have sat on the proposal for Trivandrum's metro (incidentally Kozhikode is also in the same boat). Trivandrum airport saw zero development for 40 years from 1960.Staggeringly, the Trivandrum port (Vizhinjam) was also delayed for 40 years, even though the deepwater container transhipment port there is now on track to handle a lot of India's container cargo, which now goes to Colombo. Instead, 4400 crores were spent on a container port at Kochi, which has only 8 meters draft and cannot compete with Colombo.Trivandrum/Vizhinjam has 24 meters in depth, which means literally the largest container ship in the world, MSC Irina, with 24,000 containers on board, can and in fact has called at this port.The LDF government twisted Adani Ports' arm and moved their logistics park for Vizhinjam, which Adani runs on contract, 200 km away to Kochi! In addition, the road and rail approaches to the port, which are necessary for ‘gateway' or upcountry containers from/to say Bangalore or Hyderabad, have been delayed for a long time over trivial land acquisition issues.These lapses are glaring, and add up to step-motherly treatment for Trivandrum. There must be a lot of resentment among the voters here about this, because their real estate values would go up quite a lot if Vizhinjam's business improves, and there will be jobs related to logistics, bunkering, cruise lines, and so on. Under the Sagarmala initiative, this is something that Trivandrum voters hope the Union Government will push forward, along with a proposed Tri-Services Maritime Command: thus both military and civil infrastructure may bring benefits.Finally, the excesses against Hindu temples, which are ruled by the Devaswom Board, packed with party cadres who may well be hostile atheists, are getting exposed broadly. There is a tradition prohibiting the entry of women between 10 and 60 years of age (ie. of childbearing age) into the shrine, which the women devotees in Kerala are broadly okay with, and don't feel particularly discriminated against. The Kerala government made a huge fuss over it, and attempted to smuggle in both non-believing women and non-Hindu women into the temple.This has troubled some of the CPI-M's traditional voters, for example the hitherto blase Ezhavas. As the attacks on Hindus continue, there is a bit of a counter-consolidation as well.There is no end: there is the huge current scandal of the theft of gold from the temple doors and dwarapalaka statues in Sabarimala (along with similar desecration in Guruvayur). There is an ongoing investigation, which ought to, if pursued properly, implicate highly connected political players. But recently, there have been instances of prosecutorial misconduct that mean likely criminals get away with, er, murder.Sowmya's alleged murderer Charlie Thomas aka Govindachamy was let off death row, because the prosecutor did not make a good enough case. An actor, Dileep, who allegedly took out a contract for a thug to rape an actress in a moving car, was let off. You guessed it, the prosecution did not make a good enough case.Incidentally, Christian churches with vast landholdings (a good bit of which was 99-year leases given during British days which has now, magically, turned into freehold), or Muslim mosques and other Waqf claimants rarely face the wrath of the State. Yes, there is a case wending its way through the courts about the peninsula of Munambam which is home to 600 families, mostly Christian fisherman, but is claimed in its entirety as a Waqf property.A net reflection of all this is that urban Hindus have begun to rethink their political views. There is a strong urban-rural divide as seen in the just-conducted local body polls. The urban, so to speak, constituencies have seen the vice-like grip of the LDF diminish a bit, but they remain strong in the rural areas. This is borne out by conversations with the rural poor, who talk about kshema pensions, NREGA, and so on as benefits they get from the State government.What this suggests is that anti-incumbency is playing its part; but the likely outcome is a return to the Tweedledum-Tweedledee “throw the rascals out every five years” syndrome of years past. The BJP is unlikely to make any quick inroads into this; they may not get many Assembly seats in 2026, and they are unlikely to get more than a couple of Lok Sabha seats in 2029.Yet, as for obvious reasons there is a Right-ward lurch in Europe, with the rise of AfD in Germany, Marine Le Pen's National Rally in France, and Nigel Farrage's Reform UK, and these parties are no longer easily put behind a cordon sanitaire, the BJP in Kerala is not any longer completely unelectable. The voters are beginning to see that it is not completely er… untouchable.It will be a long, painful journey, but maybe in a decade or two, the BJP can become a realistic opposition party in Kerala. To do this in the extreme South, in the very bastion of the Communists, as well as in a State with very large non-Hindu populations, would be quite an achievement for them. We shall have to wait and see if they have the stamina and the staying power for this grueling odyssey.Malayalam podcast of this essay by notebookLM: 1650 words, 15 Dec 2025 This is a public episode. If you'd like to discuss this with other subscribers or get access to bonus episodes, visit rajeevsrinivasan.substack.com/subscribe

"If you are not dreaming big or living big you are not in the right rooms with the right people." This is what our friend Trey Peterson said during our conversation.   Trey is a wealth of knowledge and a man of God that we highly respect and we had the honor of having him on our show.   In this conversation we discussed "Building a God-Driven Business, Family, Legacy, and Much More."   Make sure you have your note pads or apps out and listen to the full episode.   Keep taking action, pursuing personal excellence, and impacting lives!   In This Episode, we discuss: Building a God-Driven Business, Family, & Legacy Trey's upbringing in church and how his dad impacted his life The importance of wealth, stewardship, and understanding finances   Follow and Connect with Trey: Instagram:  https://www.instagram.com/treycpeterson/ Website: https://treycpeterson.com/ Summit Leadership & Coaching: https://growwithsummit.com/ Elevate Life Wealth: https://elevatelifewealth.com/   Trey's Bio: Trey C. Peterson is the Partner and Co-Founder of All Things Financial, a top-ranked fiduciary wealth management and tax strategy firm with offices in Minnesota and Texas. Since 2015, he's taught over 450 retirement and financial planning classes, helping thousands of families retire with clarity, confidence, and legacy in mind.  A graduate of Oral Roberts University and the National Institute of Christian Leadership, Trey leads with faith, vision, and conviction. Raised in a ministry home, he learned early to serve God, think differently, dream boldly, and love people well.  After spending years chasing success that left him unfulfilled, Trey became passionate about helping others discover purpose, align their gifts, and win in every area of life—from faith to finances. He is also the founder of two leadership and coaching companies -focused on equipping high-capacity entrepreneurs and professionals to multiply their impact and lead with integrity.   Follow Us: Instagram: https://www.instagram.com/chrisandericmartinez/ YouTube: https://www.youtube.com/user/Dynamicduotraining    *Free Online Training: Discover How Nutrition and Fitness Coaches Install a Proven System That Adds Six Figures to Their Business   Without posting endless organic content, sending 100's of cold DM's, and charging low ticket priced programs   Watch Here   See the full Show Notes to this episode here: https://www.liveadynamiclifestyle.com/podcast/building-a-god-driven-business-family-and-legacy-with-trey-peterson/  

Welcome to Ozempic Weightloss Unlocked, the podcast that unpacks how this medication is reshaping health, lifestyle, and the future of weight management.Ozempic is a brand name for semaglutide, a medication originally approved to treat type two diabetes. It mimics a gut hormone that helps the pancreas release insulin, lowers blood sugar, slows stomach emptying, and signals the brain to feel full sooner. The result for many people is significant weight loss, which is why a higher dose of the same drug is sold separately for obesity under the name Wegovy, according to the United States Food and Drug Administration and the National Institutes of Health.Because of this dual effect on blood sugar and appetite, Ozempic has become a cultural phenomenon. Listeners hear about it from celebrities, social media, and even coworkers, but medical experts keep stressing one key point. These are prescription drugs meant for people with type two diabetes or with obesity and related health risks, not quick fixes for casual weight loss. Major medical groups such as the American Diabetes Association and the Obesity Society are pushing to protect access for patients who truly need them.Recently, attention has shifted to what happens beyond the number on the scale. Some people lose not only fat but also muscle, which can affect strength, mobility, and metabolism. Researchers at Karolinska Institutet and Stockholm University, writing in the journal Cell, report a new tablet treatment that increases fat burning and improves blood sugar while preserving muscle mass, and it works very differently from Ozempic. Instead of acting on appetite in the brain, it targets skeletal muscle directly, and early trials suggest it may be used alone or even combined with a drug like Ozempic in the future.At the same time, the competition in obesity medicine is heating up. Eli Lilly has developed a so called triple hormone drug called retatrutide that activates three receptors instead of one. Eli Lilly and coverage from outlets like ABC News report that in a large trial of people with obesity and knee osteoarthritis, participants on the highest dose lost nearly twenty nine percent of their body weight on average and saw a big drop in knee pain. While retatrutide is still in clinical trials and not yet approved, it shows how the field is racing to go beyond the results seen with Ozempic alone.For listeners, this rapid progress brings both excitement and responsibility. These medications can improve blood sugar, reduce cardiovascular risk, and help treat diseases linked to excess weight, but they can also cause nausea, vomiting, diarrhea, and in some cases gallbladder or pancreatic issues. Long term use may require monitoring of muscle mass, nutrition, and mental health. Physicians are now talking more about pairing these drugs with resistance training, adequate protein, and psychological support so that weight loss does not come at the cost of strength or well being.Ozempic has also raised bigger questions. Who should get access when supplies are limited. How will insurance handle long term therapy for what is often a chronic condition. And what happens if a person stops the medication and the hunger comes back. Early data suggest that for many, maintaining results may require ongoing treatment, much like blood pressure medicine.On Ozempic Weightloss Unlocked, we will keep tracking all of this. From new trials and pill based options, to combination therapies, insurance changes, and real world stories of how life looks on and off these medications, our goal is to give you clear, balanced information so you can have better conversations with your own health care team.Thank you for tuning in, and remember to subscribe so you never miss an update on the evolving world of Ozempic and weight loss science.This has been a quiet please production, for more check out quiet please dot ai. Some great Deals https://amzn.to/49SJ3QsFor more check out http://www.quietplease.aiThis content was created in partnership and with the help of Artificial Intelligence AI

In this episode, Director of the National Institutes of Health Jay Bhattacharya discusses the latest developments in biomedical innovation and how they will shape the future of public health research.   Background Reading: This CFR event discusses emerging threats to public health and how journalists are covering new outbreaks across the United States.   Host: Sylvia Mathews Burwell, Senior Professorial Lecturer and President Emerita, American University; Former U.S. Secretary of Health and Human Services   Guests: Jay Bhattacharya, Director, National Institutes of Health   Want more comprehensive analysis of global news and events straight to your inbox? Subscribe to CFR's Daily News Brief newsletter. To keep tabs on all CFR events, visit cfr.org/event. To watch this event, please visit it on our YouTube channel: A Conversation With Jay Bhattacharya of the National Institutes of Health.

Softer rhetoric on China, but an intensified drive for economic and technological supremacy. A renewed Monroe Doctrine and a Western Hemisphere that tops America national priorities—is the 2025 U.S. National Security Strategy a real shift in American foreign policy, or just old wine in new bottles? In this episode, we explore how America's new National Security Strategy affects China-U.S. relations and what it means for Global South countries and the broader world order. Host Xu Yawen is joined by Zhao Hai, Director of International Political Studies at the National Institute for Global Strategy, Chinese Academy of Social Sciences; Wang Haolan, Research Assistant at the Asia Society Policy Institute's Center for China Analysis; Clifford Kiracofe, Washington-based author and former Senior Professional Staff Member of the U.S. Senate Committee on Foreign Relations; and George Tzogopoulos, Director of EU-China Programmes and Senior Research Fellow at the European Institute of Nice.

In this episode, Dr Elle Wadsworth talks to Dr Emmert Roberts, Senior Clinical Lecturer at the National Addiction Centre, King's College London and a Consultant Addiction Psychiatrist at the South London and the Maudsley NHS Foundation Trust. The interview covers Emmert's short report examining the characteristics of drug-related deaths among individuals identified as LGBTQ+ in the United Kingdom, 1997–2024.LGBTQ+ stands for Lesbian, Gay, Bisexual, Trans, Queer and others. The importance of examining drug-related deaths among those in the LGBTQ+ community [01:31]The use of the National Program on Substance Use Mortality database [04:00]The main findings of the study [05:05] The types of drugs used in sexualised and non-sexualised drug use [08:31]The limitations of the reporting of sexual orientation or trans status in coroner data [10:18]Improving the reporting of sexual orientation and trans status in coroner data [13:02]The implications of the findings for policy and practice [16:04]A sneak preview of findings from Emmert's other paper in Addiction on methamphetamine-related deaths [17:07]The findings that were surprising to Emmert [18:59]About Elle Wadsworth: Elle is an academic fellow with the Society for the Study of Addiction. She is based at the University of Bath with the Addiction and Mental Health Group and her research interests include drug policy, cannabis legalisation, and public health. About Emmert Roberts: Emmert is a Senior Clinical Lecturer at the National Addiction Centre, King's College London and a Consultant Addiction Psychiatrist at the South London and the Maudsley NHS Foundation Trust. He is a National Institute of Health and Care Research (NIHR) Advanced Fellow, a Senior Harkness Fellow at the Commonwealth Fund and the Clinical Lead of the National Program on Substance Use Mortality (NPSUM).Authors have no conflicts of interest to declare.Original article: Characteristics of drug-related deaths among individuals identified as LGBTQ+ in the United Kingdom, 1997–2024 https://doi.org/10.1111/add.70198 The opinions expressed in this podcast reflect the views of the host and interviewees and do not necessarily represent the opinions or official positions of the SSA or Addiction journal.The SSA does not endorse or guarantee the accuracy of the information in external sources or links and accepts no responsibility or liability for any consequences arising from the use of such information. Hosted on Acast. See acast.com/privacy for more information.

Borderline Personality Disorder (also known as Emotionally Unstable Personality Disorder), is characterised by strong emotional responses, unstable relationships and a disturbed sense of self. In this video we cover the symptoms (including DSM 5 diagnostic criteria) as well as potential causes, and treatment. PDFs available here: https://rhesusmedicine.com/pages/psychiatryFree Practice Material: https://app.wisdolia.com/learning-journey/all-cards/h1JbWDFGFLCZtYCAZkfu?showListView=true&r=DnwHGyl95QQgP3ecVSPDHrFGE0E0qB&ref=rhesusmedicineConsider subscribing (if you found any of the info useful!): https://www.youtube.com/channel/UCRks8wB6vgz0E7buP0L_5RQ?sub_confirmation=1Patreon: https://www.patreon.com/rhesusmedicineBuy Us A Coffee!: https://www.buymeacoffee.com/rhesusmedicineTimestamps:What is a personality disorder? 0:00What is Borderline Personality Disorder? 0:20 Borderline Personality Disorder Symptoms 0:45Borderline Personality Disorder Diagnosis / DSM 5 Criteria 1:49Borderline Personality Disorder Causes / Risk Factors 2:06Complications 3:12Borderline Personality Disorder Treatment 3:59LINK TO SOCIAL MEDIA: https://www.instagram.com/rhesusmedicine/ReferencesPriory Group, 2022. Emotionally unstable personality disorder (EUPD) treatment. [online] Available at: https://www.priorygroup.com/mental-health/personality-disorder-treatment/emotionally-unstable-personality-disorder-eupd.National Institute of Mental Health (NIMH), 2025. Borderline personality disorder. [online] Available at: https://www.nimh.nih.gov/health/topics/borderline-personality-disorder.Verywell Mind, 2025. Borderline personality disorder: Symptoms and diagnosis. [online] Available at: https://www.verywellmind.com/borderline-personality-disorder-diagnosis-425174.National Center for Biotechnology Information (NCBI), 2025. Borderline personality disorder. [online] Available at: https://www.ncbi.nlm.nih.gov/books/NBK430883/.Disclaimer: Please remember this podcast and all content from Rhesus Medicine is for educational and entertainment purposes only and is not a guide to diagnose or to treat any form of condition. The content is not to be used to guide clinical practice and is not medical advice. Please consult a healthcare professional for medical advice.

経済産業省、東京都千代田区経済産業省は１２日、同省所管の産業技術総合研究所が、北海道千歳市に最先端半導体の研究開発拠点を整備すると発表した。 Japan's industry ministry said Friday that its affiliated National Institute of Advanced Industrial Science and Technology, or AIST, will establish a research and development base for advanced semiconductors in Chitose, Hokkaido, northernmost Japan.

Members of the military have a duty to obey lawful orders but must not obey patently unlawful orders. Given the administration's unlawful, deadly strikes in international waters, our troops are being put in difficult and dangerous circumstances by Donald Trump and Pete Hegseth. The National Institute of Military Justice has created The Orders Project to provide real-time, informed advice for military members who are trying to lawfully navigate the difficult situation in which they are being put. Glenn spoke with Treb Courie, Legal Director for The Orders Project, about the services available to our military members. Link to The Orders Project: www.ordersproject.comFind Glenn on Substack: glennkirschner.substack.comSee Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

The killing of Alberto Rangel, a 51-year-old social worker at San Francisco General Hospital, has left colleagues grieving and questioning whether his death could have been prevented. Rangel was stabbed by a patient who authorities say had made multiple threats for weeks. Incidents of workplace violence in healthcare facilities have been on the rise for more than a decade nationwide, prompting hospitals and medical offices to adopt stricter safety protocols. But are they working? We'll talk about workplace violence against health care workers and what employers are doing – and failing to do – to protect them. Guests: Annie Vainshtein, reporter, San Francisco Chronicle Dani Golomb, psychiatrist; Golomb was attacked by a patient in 2020 during her medical residency at California Pacific Medical Center in San Francisco Dan Russell, president, University Professional and Technical Employees Al'ai Alvarez, clinical professor of emergency medicine, Stanford University Cammie Chaumont Menendez, research epidemiologist, Centers for Disease Control and Prevention's National Institute for Occupational Safety and Health Learn more about your ad choices. Visit megaphone.fm/adchoices

Members of the military have a duty to obey lawful orders but must not obey patently unlawful orders. Given the administration's unlawful, deadly strikes in international waters, our troops are being put in difficult and dangerous circumstances by Donald Trump and Pete Hegseth. The National Institute of Military Justice has created The Orders Project to provide real-time, informed advice for military members who are trying to lawfully navigate the difficult situation in which they are being put. Glenn spoke with Treb Courie, Legal Director for The Orders Project, about the services available to our military members. Link to The Orders Project: www.ordersproject.comFind Glenn on Substack: glennkirschner.substack.comSee Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

Send us a textSummary: Microplastics are showing up in our water, food, air—and in human tissues. In this episode, I unpack what the best studies actually show (and don't), why risk is plausible but not proven, and the realistic steps you can take today without panic. In this episode, I cover:What microplastics are and why they're everywhere—from packaging and clothing to tire dust—and why production is still projected to rise ~70% by 2040 (OECD). OECD+2OECD+2The signal that caught my attention: patients with microplastics in carotid artery plaque had a markedly higher 3-year risk of heart attack, stroke, or death (NEJM). Association, not proof—but concerning. The Guardian+3New England Journal of Medicine+3PubMed+3What's turning up in the brain: autopsy work suggests rising microplastic loads in brain tissue, though causality remains unknown (Nature Medicine coverage). Nature+2Nature+2Everyday exposure: a liter of bottled water can contain ~240,000 plastic particles—mostly nanoplastics—using newer detection methods (NIH Research Matters). TIME+3National Institutes of Health (NIH)+3NCBI+3Indoor vs. outdoor air: estimates suggest we inhale tens of thousands of microplastic particles daily, with higher indoor concentrations (PLOS One). PLOS+1My takeaways for you (progress, not perfection):Respect the signal without catastrophizing. Human data are early, but cardiovascular and neurologic signals merit attention. New England Journal of Medicine+1Make the easy swaps: store food in glass, don't microwave plastic, favor loose-leaf tea over plastic-based tea bags, and replace plastic cutting boards with wood or glass. (These trim exposure; they don't eliminate it.) Air matters: consider a HEPA purifier for main living/sleeping areas and vacuum regularly; natural-fiber clothing sheds fewer synthetic particles. Water choices: where safe, use tap water with a quality home filter and a reusable (non-plastic) bottle—especially given the nanoplastic findings in some bottled waters. National Institutes of Health (NIH)Listener corner: You asked for more quick-hit myth busters (yes, we'll do “Does chicken soup speed recovery?”), and thanks for the reminder to wear a

In this solo episode, Dr. Mike delves into the complex relationship between dopamine, romantic relationships, and the Coolidge Effect. The discussion highlights why men often feel the need for a new partner due to a desensitization of dopamine and how our overstimulated lifestyles contribute to this issue. The host explores the impact of modern habits on dopamine levels, the importance of boredom for resetting dopamine sensitivity, and the role of anticipation in maintaining desire. Practical solutions like dopamine resets, engaging in effort-based activities, and ensuring personal growth and solitude are discussed as ways to improve both individual well-being and relationship satisfaction. Links: The Dopamine Collapse Hypothesis: Foundations of Macro-Neuroeconomics   Show Notes: 00:00 Welcome back to the Hart2Heart Podcast with Dr. Mike Hart 01:30 Understanding the dopamine cycle 03:30 Daily habits and dopamine desensitization 09:00 The Coolidge effect and relationship dynamics 15:00 Dopamine resets and effort-based activities 22:00 Reviving desire in long-term relationships 28:38 "Our nervous system never gets any time to recover—and that kills desire."   — The Hart2Heart podcast is hosted by family physician Dr. Michael Hart, who is dedicated to  cutting through the noise and uncovering the most effective strategies for optimizing health,  longevity, and peak performance. This podcast dives deep into evidence-based approaches to  hormone balance, peptides, sleep optimization, nutrition, psychedelics, supplements, exercise  protocols, leveraging sunlight light, and de-prescribing pharmaceuticals—using medications only when absolutely necessary.   Beyond health science, we tackle the intersection of public health and politics, exposing how  policy decisions shape our health landscape and what actionable steps people can take to reclaim control over their well-being.   Guests range from out-of-the-box thinking physicians such as Dr. Casey Means (author of "Good Energy") and Dr. Roger Sehult (Medcram lectures) to public health experts such as Dr. Jay Bhattacharya (Director of the National Institutes of Health (NIH) and Dr. Marty Mckary  (Commissioner of the Food and Drug Administration (FDA) and high-profile names such as  Zuby and Mark Sisson (Primal Blueprint and Primal Kitchen).   If you're ready to take control of your health and performance, this is the podcast for you. We cut through the jargon and deliver practical, no-BS advice that you can implement in your daily life, empowering you to make positive changes for your well-being.   Connect on social with Dr. Mike Hart: Instagram: @drmikehart Twitter: @drmikehart Facebook: @drmikehart  

Bipolar disorder is a mood disorder that is characterised by alternating periods of depressive symptoms and elevated mood, termed either hypomania or mania. We cover the different types of bipolar disorder, the criteria for diagnosis and treatment options. PDFs available here: https://rhesusmedicine.com/pages/psychiatryFree Practice Material: https://app.wisdolia.com/learning-journey/all-cards/rlEkoudd56tl7ILuiiVK?showListView=true&r=DnwHGyl95QQgP3ecVSPDHrFGE0E0qB&ref=rhesusmedicineConsider subscribing (if you found any of the info useful!): https://www.youtube.com/channel/UCRks8wB6vgz0E7buP0L_5RQ?sub_confirmation=1Patreon: https://www.patreon.com/rhesusmedicineBuy Us A Coffee!: https://www.buymeacoffee.com/rhesusmedicineTimestamps:0:00 What is Bipolar Disorder?0:33 Bipolar Disorder - Depression1:10 Bipolar Disorder - Mania vs Hypomania2:14 Bipolar Disorder Classification - (Bipolar Disorder 1 vs Bipolar Disorder 2 vs Cyclothymia) 3:15 Epidemiology and Risk Factors4:22 Bipolar Disorder Treatment LINK TO SOCIAL MEDIA: https://www.instagram.com/rhesusmedicine/ReferencesNational Alliance on Mental Illness (NAMI), 2025. Bipolar Disorder. [online] Available at: https://www.nami.org/About-Mental-Illness/Mental-Health-Conditions/Bipolar-Disorder.Psycom Pro, 2025. Bipolar Disorder. [online] Available at: https://pro.psycom.net/assessment-diagnosis-adherence/bipolar-disorder.National Institute of Mental Health (NIMH), 2025. Bipolar Disorder. [online] Available at: https://www.nimh.nih.gov/health/publications/bipolar-disorder.Wikipedia, 2025. Bipolar disorder. [online] Available at: https://en.wikipedia.org/wiki/Bipolar_disorder.Verywell Mind, 2025. Will My Child Inherit My Bipolar Disorder?. [online] Available at: https://www.verywellmind.com/will-my-child-inherit-my-bipolar-disorder-380477.Disclaimer: Please remember this video and all content from Rhesus Medicine is for educational and entertainment purposes only and is not a guide to diagnose or to treat any form of condition. The content is not to be used to guide clinical practice and is not medical advice. Please consult a healthcare professional for medical advice.

The National Institutes of Health have historically funded scientists to find cures for diseases and protect public health. NIH funding has led to the discovery of immune therapies for cancer, antiviral treatments and prevention of HIV, and ground-breaking research into memory loss and Alzheimer's disease. After a year of funding cuts and freezes that have rocked the medical research field to its core, we catch up with leading researchers at the University of California to talk about the impact this has had on their work and our ability to fight humanity's most puzzling illnesses. Guests: Monica Gandhi, infectious disease expert and professor of medicine at University of California San Francisco - she is the director of the UCSF Gladstone Center for AIDS Research and the medical director of the San Francisco General Hospital HIV Clinic, Ward 86 Pamela Munster, professor of medicine at the University of California San Francisco; co-director, Center for BRCA Research, Medical Oncology; distinguished professor in Hereditary Cancer Research Megan Molteni, science writer, STAT News Joel Spencer, associate professor of Bioengineering, University of California Merced - his lab uses funding from NIH to study the thymus, with implications for cancer treatment and healthy aging Learn more about your ad choices. Visit megaphone.fm/adchoices

If Christians are called to shape systems, then we must understand what distinguishes a Kingdom model from a worldly machine. Dr. Rutland brings clarity, simplicity, and unmatched leadership wisdom to this crucial distinction.  What You'll Learn in Part 2: How to identify the spirit, values, and drivers of worldly systems. What defines a Kingdom-driven system: righteousness, integrity, service, stewardship, and vision. Why leadership in the Kingdom is built on honor, humility, and accountability. How systems either form people into their image or free people into God's image. Why the Kingdom model produces transformation, not exploitation. A Word from Dr. Mark Rutland "Worldly systems demand success. Kingdom systems cultivate significance. One uses people—the other raises them." ABOUT DR. MARK RUTLAND — The Man, The Myth, The Legend Dr. Mark Rutland is a pastor, evangelist, educator, and New York Times best-selling author. His leadership journey has shaped universities, churches, and global missions. He has served as: Senior Pastor, Calvary Assembly of God, Orlando, FL President, Southeastern University, Lakeland, FL President, Oral Roberts University, Tulsa, OK Founder & Director, National Institute of Christian Leadership He also leads Global Servants, rescuing vulnerable girls from trafficking through the incredible House of Grace in Thailand. His life is a testament to the power of moving with God's voice—and His timing.

This is a free preview of a paid episode. To hear more, visit ianmsc.substack.comDr. Jay Bhattacharya is the director of the National Institutes of Health, the organization formerly run by Dr. Francis Collins and Dr. Anthony Fauci. But Dr. Bhattacharya's importance extends much further than “just” NIH. And his appointment there under the second Donald Trump administration marked a dramatic about-face for an organization that was instrumental in creating many of the issues and problems we faced as a society during the pandemic.Dr. Bhattacharya was one of the authors of the Great Barrington Declaration in 2020. That paper contained a blueprint for focused protection during the COVID-19 pandemic. Instead of locking down all society, Bhattacharya and his co-authors wrote, we should look to protect the most vulnerable. That's been proven prophetic, as the harms from lockdowns far exceeded any benefits.He also conducted a study in Silicon Valley early on in the lockdowns that identified COVID was far more prevalent in the community than people realized. That meant the virus was also far less deadly than organizations like the World Health Organization had suggested. He was skeptical about the efficacy of cloth masks, advocated for opening schools, and participated in a roundtable hosted by Florida Gov. Ron DeSantis in 2021 that illustrated how ineffectual the Anthony Fauci-doctrine had been. Around that same time, Bhattacharya also spoke out against vaccine mandates and other abuses, which decreased public confidence and trust in vaccines.In short, he was a voice of sanity in a sea of absurdity, proven right about nearly every pandemic-related policy. For his efforts, he was demonized, labeled, censored, and targeted by Collins and Fauci in emails. I had the exclusive opportunity to ask him about many of these issues, and what he's bringing to NIH that his predecessors didn't.Unmasked is a reader-supported publication. To receive new posts and support my work, consider becoming a free or paid subscriber.

In today's Cloud Wars Minute, I look at how IBM and Cisco are teaming up to pioneer long-distance quantum networks.Highlights00:03 — Although not the only company invested in the development of quantum computing, IBM is certainly considered the most active. The company has the highest number of patents, a clear road map for fault tolerant quantum systems, and the most prestigious track record across quantum hardware, software and the commercialization of these tools.00:28 — Now, IBM and Cisco Systems have revealed plans to link a network of quantum computers over long distances — and the result, perhaps the introduction of the quantum internet. Before I get carried away on this, leaders from both IBM and Cisco have confirmed that the technology to power these networks doesn't yet exist, but they are working on it.00:59 — The bottleneck is getting qubits, the unit of information used by quantum computers, to travel along fiber optic cables between Cisco switches. IBM and Cisco hope to have the first proof-of-concept ready within five years, a network that connects individual, large scale, fault-tolerant quantum computers with the power to run computations over 10s to hundreds of 1000s of qubits.01:49 — So, why do we need the quantum internet? Well, beyond the massive enhancement in computational power, which is the primary driver for companies to enter this space, if quantum computing itself becomes widespread, we'll need quantum structures in the Internet to protect ourselves from our very own creation.02:28 — Technology is advancing at an unfathomable speed, and just like in the AI space, we need to ensure it's contained. In fact, researchers at IBM co-developed three of the four quantum resistant algorithms that the U.S. National Institute of Standards and Technology, or NIST, have earmarked for future standardization. Visit Cloud Wars for more.

Plastics are everywhere. In the clothes we wear, the food we eat, and even running through our brains. While environmental concerns like pollution, toxic spills and trash islands make the problem feel insurmountable, a new book aims to break down the major issue into solvable problems. “The Problem with Plastic: How We Can Save Ourselves and Our Planet Before It's Too Late" was written by Judith Anck, founder and president of Beyond Plastic, and Adam Mahoney, climate and environmental reporter for Capital B News. Adam joins us for more on the book.The National Institutes of Health recently awarded a research grant to LSU Health to support its research into patients living with HIV-AIDS. Specifically, researchers will study how alcohol use and other issues affect patients with the virus.Dr. Patricia Molina, senior associate dean for research at the LSU School of Medicine, and director of the Comprehensive Alcohol-HIV/AIDS Research Center, and Dr. David Welsh, LSU professor of medicine in pulmonary and critical care medicine, join us to discuss their research. —Today's episode of Louisiana Considered was hosted by Adam Vos. Our managing producer is Alana Schreiber. We get production support from Garrett Pittman and our assistant producer, Aubry Procell.You can listen to Louisiana Considered Monday through Friday at noon and 7 p.m. It's available on Spotify, the NPR App and wherever you get your podcasts. Louisiana Considered wants to hear from you!Please fill out our pitch line to let us know what kinds of story ideas you have for our show. And while you're at it, fill out our listener survey! We want to keep bringing you the kinds of conversations you'd like to listen to.Louisiana Considered is made possible with support from our listeners. Thank you!

In this episode, Regan Archibald shifts the conversation from physical longevity to financial longevity, exploring why financial stability is one of the strongest predictors of overall health. Joined by wealth experts Bryan Sweet and Sonu Varghese, the discussion unpacks the biggest risks entrepreneurs face—especially unexpected tax burdens when selling a business—and introduces the powerful concept of creating a “tax asset” to offset capital gains without losing investment growth. Through real case studies, they reveal how proactive planning, strategic portfolio design, and collaboration with the right advisors can save clients hundreds of thousands to millions in taxes while maintaining liquidity, reducing risk, and fueling long-term lifestyle freedom. The episode emphasizes that true longevity requires both optimized health and optimized finances—and that smart tax strategy is essential to building the ageless future you envision. Bryan J. Sweet, CLU, ChFC, MSFS, is the Managing Partner and Wealth Advisor at Sweet Financial Partners and a multi-year Forbes Best-in-State Wealth Advisor. Since launching his career in 1979, he has helped clients design purposeful retirements through his proprietary framework, The Dream Architect™, which blends strategic distribution planning with achieving life's biggest goals. Bryan also co-leads the Elite Wealth Advisor Symposium, mentoring top advisors nationwide in scaling, marketing, and team excellence. His passion is helping others build world-class practices while creating the freedom to live their own dream-driven lives.Personal LinkedIn: https://www.linkedin.com/in/bryansweet/ SFP LinkedIn: https://www.linkedin.com/company/sweet-financial- partners/mycompany/?viewAsMember=true SFP Website: https://sweetfinancial.com/ EWAS Website: https://www.ewasymposium.com/ewas-home Sonu has over 20 years of experience in the asset management industry and leads Carson Group's asset allocation team, shaping the firm's market outlook and providing macro, policy, and portfolio guidance to more than 130 partners overseeing $42 billion in assets. He manages multiple strategic and tactical allocation models on the Carson Investment platform and specializes in the intersection of markets, the economy, and policy. Previously, he served as Partner and Director of Research at Convex Capital Management, where he co-managed portfolios and developed proprietary economic indicators across 30 countries. Sonu began his finance career while completing his Ph.D. in Mechanical Engineering at Purdue University, following both an M.S. from Purdue and a B.E. from the National Institute of Technology in India.LinkedIn: https://www.linkedin.com/in/sonu-varghese-phd/  X: https://x.com/sonusvarghese  LIKE/FOLLOW/SUBSCRIBE AGELESS FUTURE:YouTube -https://www.youtube.com/@ReganArchibald / https://www.youtube.com/@Ageless.FutureLinkedIn: https://www.linkedin.com/in/regan-archibald-ab70b813Instagram: https://www.instagram.com/ageless.future/Facebook: https://www.facebook.com/AgelessFutureHealth/

Many Christians understand purpose—but still miss timing. Dr. Rutland confronts one of the most overlooked truths: God's will requires God's timing. Purpose without timing creates chaos. Timing without obedience creates delay. But when purpose and timing align—systems shift, doors open, and favor flows. What You'll Learn in Part 1 Why divine timing is a spiritual discipline, not a coincidence. How to discern the difference between your timing and God's timing. Why rushing God's process leads to unnecessary warfare. How prophets and leaders can cultivate sensitivity to God's pace. Why being "late in the spirit" can cost you opportunities God intended for you to carry. A Word from Dr. Mark Rutland "God is never early and never late—but we often are. Maturity is learning to walk at His pace, even when everything around you tells you to run." ABOUT DR. MARK RUTLAND — The Man, The Myth, The Legend Dr. Mark Rutland is a pastor, evangelist, educator, and New York Times best-selling author. His leadership journey has shaped universities, churches, and global missions. He has served as: Senior Pastor, Calvary Assembly of God, Orlando, FL President, Southeastern University, Lakeland, FL President, Oral Roberts University, Tulsa, OK Founder & Director, National Institute of Christian Leadership He also leads Global Servants, rescuing vulnerable girls from trafficking through the incredible House of Grace in Thailand. His life is a testament to the power of moving with God's voice—and His timing.

Discusses voice as a biomarker of diseases, including ethical considerations and how this technology could change the way we diagnose and monitor diseases.  Our guest today is Yael Bensoussan, who is an Assistant Professor of Otolaryngology at the University of South Florida Health Morsani College of Medicine and a fellowship-trained laryngologist. She is also the principal investigator of the Bridge2AI-Voice project, a multi-institutional endeavor funded by the National Institutes of Health to fuel voice as a biomarker of diseases.  Additional resources: Bridge2AI-Voice: https://b2ai-voice.org/ Voice AI Symposium: https://b2ai-voice.org/voice-ai-symposium/ CITI Program's course catalog: https://about.citiprogram.org/course-catalog 

Guest: Anne O'ConnorOrganization: National Institute of Family & Life AdvocatesPosition: Vice President of Legal AffairsTopic: a federal appeals court decision allowing pregnancy resource centers in New York state to continue to inform women about Abortion Pill Reversal while the case progresses in courtWebsite: nifla.org

Many Christians understand purpose—but still miss timing. Dr. Rutland confronts one of the most overlooked truths: God's will requires God's timing. Purpose without timing creates chaos. Timing without obedience creates delay. But when purpose and timing align—systems shift, doors open, and favor flows. What You'll Learn in Part 1 Why divine timing is a spiritual discipline, not a coincidence. How to discern the difference between your timing and God's timing. Why rushing God's process leads to unnecessary warfare. How prophets and leaders can cultivate sensitivity to God's pace. Why being "late in the spirit" can cost you opportunities God intended for you to carry. A Word from Dr. Mark Rutland "God is never early and never late—but we often are. Maturity is learning to walk at His pace, even when everything around you tells you to run." ABOUT DR. MARK RUTLAND — The Man, The Myth, The Legend Dr. Mark Rutland is a pastor, evangelist, educator, and New York Times best-selling author. His leadership journey has shaped universities, churches, and global missions. He has served as: Senior Pastor, Calvary Assembly of God, Orlando, FL President, Southeastern University, Lakeland, FL President, Oral Roberts University, Tulsa, OK Founder & Director, National Institute of Christian Leadership He also leads Global Servants, rescuing vulnerable girls from trafficking through the incredible House of Grace in Thailand. His life is a testament to the power of moving with God's voice—and His timing.

In this insightful interview, Dr. Emeran Mayer, a renowned expert in the gut-brain axis, discusses the profound impact of gut health on our psychological and mental well-being. Learn about the latest scientific discoveries connecting your gut microbiome to your brain and how modern agriculture, diet, and environmental factors play a crucial role. Topics Covered Start (00:00) Dr. Mayer's Background (01:36) Cutting-Edge Discoveries in Gut-Brain Connection (04:12) Impact of Modern Agriculture on Gut Health (07:18) The Role of GMOs and Glyphosate (12:28) Microplastics and Potential Microbial Solutions (17:48) Soil-Grown vs. Hydroponic Foods (22:05) Benefits of Regenerative Agriculture (27:19) Understanding Bovar (27:42) The Power of Polyphenols for Gut and Brain Health (34:54) Importance of Microbiome Diversity (42:01) Key Beneficial Bacteria: Butyrate Producers & Akkermansia (48:28) Fermented Foods and Mental Health (53:40) The Microbiome and Psychedelics (01:01:48) The Importance of Diet for Gut-Brain Health (01:04:18) Learn more about the fascinating link between your gut and your mind in this engaging discussion with a leading expert in the field. About Dr Emeran Mayer: Dr. Emeran Mayer is a distinguished professor in the departments of medicine, physiology, psychiatry, and biobehavioral sciences at the David Geffen School of Medicine at the University of California, Los Angeles (UCLA). He is also the director of the Center for Neurovisceral Sciences & Women's Health within UCLA's division of digestive diseases and the executive director of the G. Oppenheimer Center for Neurobiology of Stress and Resilience. Furthermore, he co-directs the CURE: Digestive Diseases Research Center at UCLA.   Dr. Mayer is a world-renowned gastroenterologist and neuroscientist with over 35 years of experience studying the clinical and neurobiological interactions between the digestive and nervous systems in both healthy and diseased states. His research has been consistently supported by the National Institutes of Health.   He is also an accomplished author, having written "The Mind-Gut Connection: How the Hidden Conversation Within Our Bodies Impacts Our Mood, Our Choices, and Our Overall Health." He has published over 320 peer-reviewed scientific articles and numerous book chapters and reviews.   Dr. Mayer's research interests include the neurobiology of visceral pain and stress, and he is involved in translational studies in these areas. He also investigates probiotic therapies for gastrointestinal disorders, including irritable bowel syndrome.   About Kriben Govender: Kriben Govender is a Food and Nutrition Scientist, Registered Nutritionist, and the founder of Nourishme Organics, a company specialising in gut health and fermentation products. With over 20 years of experience in the food industry, Kriben is passionate about the intersection of diet, gut health, and well-being.

Dan Naturman and Periel Aschenbrand are joined by Nate Soares, President of the Machine Intelligence Research Institute (MIRI) and author of the New York Times bestseller If Anyone Builds It, Everyone Dies: Why Superhuman AI Would Kill Us All. Prior to MIRI, Soares worked as an engineer at Google and Microsoft, as a research associate at the National Institute of Standards and Technology, and as a contractor for the US Department of Defense.Dan Naturman and Periel Aschenbrand are joined by Nate Soares, President of the Machine Intelligence Research Institute (MIRI) and author of the New York Times bestseller If Anyone Builds It, Everyone Dies: Why Superhuman AI Would Kill Us All. Prior to MIRI, Soares worked as an engineer at Google and Microsoft, as a research associate at the National Institute of Standards and Technology, and as a contractor for the US Department of Defense.

Dustin Poppendieck is an environmental engineer at the National Institute of Standards and Technology (NIST). He received his PhD in Civil and Environmental Engineering from the University of Texas at Austin in 2002. He is a fellow of the International Society for Indoor Air Quality and Climate (ISIAQ). Dustin has been investigating indoor air chemistry since 2002. Most of his efforts have involved characterizing primary emission sources and heterogeneous reactions at material surfaces. He has investigated emissions from kerosene can lamps used by nearly a billion people throughout the developing world, spray polyurethane foam, non-smoldering cigarette butts and indoor air cleaning devices. In addition, Dustin has studied the disinfection of biologically contaminated building materials (i.e., anthrax) using high concentrations of ozone, chlorine dioxide, hydrogen peroxide and methyl bromide. Recently, Dustin has been involved in writing and revising standards related to chemistry of portable air cleaners, including ASTM D8625, UL867, ASHRAE 241 and ASHRAE 145.4.

According to the National Institutes of Health,approximately 61% of children with autism exhibit behavioral or conductproblems, based on a large study. However, the prevalence of these behavioralissues can vary significantly depending on the definitions used, with estimatesfor specific aggressive behaviors ranging from 8% to over 68%. Jake Edgar is a Special Education Director and Advisor whohas dedicated his career to empowering children and adolescents withdisabilities and supporting the families who care for them. He has alwaysfollowed his passion for helping young people reach their full potential.Currently, he serves as the Director of Education at Springbrook AutismBehavioral Health, a residential program that provides specialized care forchildren and teens who are autistic and also face behavioral or emotionalchallenges. Jake is also the founder of the Carolina Special EducationAdvocacy Group, where he works directly with parents and families to navigatethe Individualized Education Program (IEP) process. He helps them understandtheir rights, develop effective plans, and gain the confidence to advocate fortheir children's educational needs. In addition, Jake hosts the All Abilities,No Filter podcast, which features real, unfiltered conversations aboutdisability, inclusion, and education. Each episode includes voices fromparents, professionals, and self-advocates, all working toward a common goal:building a more understanding and inclusive world. His passion has always centered on helping children andadolescents with disabilities reach their fullest potential. Over the years,Jake has had the privilege of working across a wide range of educationalsettings—from self-contained classrooms to public school inclusionenvironments, and now in residential care. Each experience has deepened hisunderstanding of the diverse needs, strengths, and stories within the specialeducation community. For more information, visit: [All Abilities, NoFilter](https://www.allabilitiesnofilter.com/) Discover more at: [Springbrook Autism BehavioralHealth](https://springbrookbehavioral.com/)

The Rich Zeoli Show- Hour 4: 6:00pm- Speaking from the Oval Office, President Trump, alongside Transportation Secretary Sean Duffy, announced a repeal of onerous fuel efficiency regulations put in place under the Biden administration. They had been designed to artificially boost electric vehicle manufacturing and sales. Trump described the policy shift as a win for consumers—as the previous efficiency standards led to higher prices on new vehicles. 6:30pm-While speaking with New York Post reporter Miranda Devine, FDA Director and Johns Hopkins surgeon Dr. Marty Makary documented the ways former Director of the National Institute of Allergy and Infectious Diseases Dr. Anthony Fauci was involved in a massive attempt to suppress the truth about Covid-19's origins. 6:40pm- A report from Ernesto Londono of The New York Times documents rampant fraud plaguing Minnesota—dozens of people have been charged with stealing more than $1 billion in taxpayer money from programs meant to feed hungry children and provide therapy for autistic children. Critics of Governor Tim Walz say his administration allowed the fraud to persist “partly because state officials were fearful of alienating the Somali community” who were largely responsible for the scams.

The Rich Zeoli Show- Full Show (12/03/2025): 3:05pm- A report from Ernesto Londono of The New York Times documents rampant fraud plaguing Minnesota—dozens of people have been charged with stealing more than $1 billion in taxpayer money from programs meant to feed hungry children and provide therapy for autistic children. Critics of Governor Tim Walz say his administration allowed the fraud to persist “partly because state officials were fearful of alienating the Somali community” who were largely responsible for the scams. 3:10pm- While speaking with the press on Tuesday, President Donald Trump called for a reduction of migrants from third world countries who are openly unwilling to assimilate to American culture. 3:20pm- Philadelphia Highway Patrol Officer Andy Chan has died six years after he was struck by a vehicle while on duty. Rich notes that Officer Chan was a friend of the show. Next Friday the show will be broadcasting from the 6th Annual Andy Chan Holiday Block Party. 3:30pm- Speaking from the Oval Office, President Trump, alongside Transportation Secretary Sean Duffy, announced a repeal of onerous fuel efficiency regulations put in place under the Biden administration. They had been designed to artificially boost electric vehicle manufacturing and sales. 4:05pm- Speaking from the Oval Office, President Trump, alongside Transportation Secretary Sean Duffy, announced a repeal of onerous fuel efficiency regulations put in place under the Biden administration. They had been designed to artificially boost electric vehicle manufacturing and sales. Trump described the policy shift as a win for consumers—as the previous efficiency standards led to higher prices on new vehicles. 4:40pm- Carrie Severino—President of the Judicial Crisis Network (JCN) & Co-Author of the book, “Justice on Trial: The Kavanaugh Confirmation and the Future of the Supreme Court.”—joins The Rich Zeoli Show. On Tuesday, the U.S. Supreme Court heard oral argument in First Choice Women's Resource Centers v. Platkin. The case asks whether a federal court can hear First Choice's First Amendment challenge to a New Jersey investigatory subpoena when no state court has yet ordered the group to comply. While being questioned by Justice Clarence Thomas, NJ Attorney General Sundeep Iyer conceded that NJ hasn't received any public complaints to justify its subpoena against the pro-life health center. 5:05pm- A Washington Post report states that Department of War Secretary Pete Hegseth authorized a series of deadly strikes on a drug trafficking boat in the Caribbean, ordering military officials to “kill everybody.” The directive, according to the report, led to a second strike killing several crew members that survived the initial assault on the vessel. The New York Times, as well as the White House, dispute that Hegseth explicitly authorized the second strike or ordered to eliminate survivors. The NYT also reports that the “U.S. military intercepted radio communications from one of the survivors to what [officials] said were narco-traffickers.” 5:30pm- Following the Eagles loss to the Bears on Friday, Offensive Coordinator Kevin Patullo had his house egged. Does Justin have an alibi? Plus, a drunk racoon ransacked a convenience store! And “Be Nice to Matt Week” continues…sort of… 6:00pm- Speaking from the Oval Office, President Trump, alongside Transportation Secretary Sean Duffy, announced a repeal of onerous fuel efficiency regulations put in place under the Biden administration. They had been designed to artificially boost electric vehicle manufacturing and sales. Trump described the policy shift as a win for consumers—as the previous efficiency standards led to higher prices on new vehicles. 6:30pm-While speaking with New York Post reporter Miranda Devine, FDA Director and Johns Hopkins surgeon Dr. Marty Makary documented the ways former Director of the National Institute of Allergy and Infectious Diseases Dr. Anthony Fauci was involved in a ma ...

Allison Lindauer, PhD, APRN joins us to tackle the challenges of navigating behavioral changes caused by Frontotemporal Degeneration (FTD). We talk about some behavior management strategies and the importance of seeking support early and prioritizing your own well-being as a caregiver. Let us know what you think when you listen. - R+MAllison Lindauer is a nationally certified nurse practitioner, researcher, and Associate Director at Oregon Health & Science University's Aging and Alzheimer's Disease Research Center, where she leads outreach and clinical care for families affected by dementia and FTD through her National Institute on Aging–funded STELLA-FTD study.Learn more about the STELLA FTD Study here. A VERY special thank you to today's sponsors ⁠Progranulin Information Navigator⁠ and ⁠Psilera⁠. Want to support the podcast + get more content? Join us on ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠Patreon⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠! You get exclusive content + a space to share and connect with others. ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠www.patreon.com/remembermecommunity⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ If you're curious about anything RM, we'd love to connect with you on ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠Instagram, and visit ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠our website at⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ www.remembermeftd.com⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠, all the latest updates! Also checkout our new charity foundation for the FTD Community www.remembermefoundation.org------Remember Me Podcast + Community is here to offer hope + human connection for families, caregivers, and individuals impacted by Frontotemporal Dementia (FTD). Always, always accept the good.

Technological development has always been a double-edged sword for humanity: the printing press increased the spread of misinformation, cars disrupted the fabric of our cities, and social media has made us increasingly polarized and lonely. But it has not been since the invention of the nuclear bomb that technology has presented such a severe existential risk to humanity – until now, with the possibility of Artificial Super Intelligence (ASI) on the horizon. Were ASI to come to fruition, it would be so powerful that it would outcompete human beings in everything – from scientific discovery to strategic warfare. What might happen to our species if we reach this point of singularity, and how can we steer away from the worst outcomes?  In this episode, Nate is joined by Nate Soares, an AI safety researcher and co-author of the book If Anyone Builds It, Everyone Dies: Why Superhuman AI Would Kill Us All. Together, they discuss many aspects of AI and ASI, including the dangerous unpredictability of continued ASI development, the "alignment problem," and the newest safety studies uncovering increasingly deceptive AI behavior. Soares also explores the need for global cooperation and oversight in AI development and the importance of public awareness and political action in addressing these existential risks.  How does ASI present an entirely different level of risk than the conventional artificial intelligence models that the public has already become accustomed to? Why do the leaders of the AI industry persist in their pursuits, despite acknowledging the extinction-level risks presented by continued ASI development? And will we be able to join together to create global guardrails against this shared threat, taking one small step toward a better future for humanity?  (Conversation recorded on November 11th, 2025)    About Nate Soares: Nate Soares is the President of the Machine Intelligence Research Institute (MIRI), and plays a central role in setting MIRI's vision and strategy. Soares has been working in the field for over a decade, and is the author of a large body of technical and semi-technical writing on AI alignment, including foundational work on value learning, decision theory, and power-seeking incentives in smarter-than-human AIs. Prior to MIRI, Soares worked as an engineer at Google and Microsoft, as a research associate at the National Institute of Standards and Technology, and as a contractor for the US Department of Defense.   Show Notes and More Watch this video episode on YouTube   Want to learn the broad overview of The Great Simplification in 30 minutes? Watch our Animated Movie.   ---   Support The Institute for the Study of Energy and Our Future Join our Substack newsletter Join our Hylo channel and connect with other listeners  

Few, if any, people are comfortable with the idea that there appears to be a connection between UFO sightings and the appearance of supposedly non-existent creatures, including Sasquatch. UFO investigators and organizations have largely shunned cases in which both UFOs and cryptic beings show up in the same locations at the same time. And the Bigfoot research groups are equally appalled to address why their flesh-and-blood but elusive primate species often vanish into thin air, as if sucked up into the sky. But the links between UFO craft and Sasquatch are getting harder to ignore. This week marks the 20th anniversary of Hunt for the Skinwalker, a book co-written by Dr. Colm Kelleher and George Knapp. It documented the strange encounters that had been reported and investigated by the NIDS organization (National Institute for Discovery Science) at a place now known as Skinwalker Ranch. That book inspired the creation of a secretive DIA program known as AAWSAP, which did NOT shy away from the pursuit of incidents in which unknown creatures, including Bigfoot, were seen in the same vicinity as UFOs, alleged dimensional portals, and other phenomena shunned by mainstream science. In this episode of WEAPONIZED, Jeremy and George speak with author and filmmaker David Paulides. Paulides is best known for his bestselling book series, “Missing 411,” in which he documents hundreds of strange disappearances that occur largely in national parks and forests. In many of these cases, humans simply vanish, as if snatched by UFOs or taken against their will to some other reality. Most are never seen again. The first two books written by the former lawman Paulides focused on Sasquatch and what Native American tribes have learned about the mysterious, hair-covered monsters that have been seen for centuries all over North America. His readers wondered if Paulides was suggesting that Sasquatch might be responsible for the humans who disappeared. Now Paulides has released a new film which thoroughly explores all sides of the Bigfoot mystery. The documentary, “American Sasquatch: Man, Myth, or Monster,” revisits the physical evidence and witness accounts which suggest that there is a disturbing connection between cryptid creatures such as Bigfoot and the sightings of UFOs, dimensional portals, and other astounding phenomena - similar to what has been widely reported in and around Skinwalker Ranch. The episode includes clips from the Paulides film, as well as from the video archives of both George and Jeremy, which have explored these same possible connections. American Sasquatch: Man, Myth, or Monster is now available to rent… https://geni.us/AmericanSasquatch GOT A TIP? Reach out to us at ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠WeaponizedPodcast@Proton.me⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ ••• Watch Corbell's six-part UFO docuseries titled UFO REVOLUTION on TUBI here : ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠https://tubitv.com/series/300002259/tmz-presents-ufo-revolution/season-2⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ Watch Knapp's six-part UFO docuseries titled INVESTIGATION ALIEN on NETFLIX here : ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠https://netflix.com/title/81674441⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ ••• You can now watch all of Corbell's movies for free on YouTube here : BOB LAZAR : AREA 51 & FLYING SAUCERS https://youtu.be/sZaE5rIavVA HUNT FOR THE SKINWALKER https://youtu.be/TczkJ6UAQ8A PATIENT SEVENTEEN https://youtu.be/gDVX0kRqXxE ••• For breaking news, follow Corbell & Knapp on all social media. Extras and bonuses from the episode can be found at ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠WeaponizedPodcast.com Learn more about your ad choices. Visit podcastchoices.com/adchoices

Cato adjunct scholars Terence Kealey and John Early join Ryan Bourne to discuss the pair's new Cato working paper Mission Lost: How NIH Leaders Stole Its Promise to America. Kealey and Early detail how the National Institutes of Health's shift from financing mission-led research to funding basic science has reduced its effectiveness in improving Americans' health, all the while crowding out cutting-edge commercial science, and funnelling taxpayer dollars to a range of questionable projects. Hosted on Acast. See acast.com/privacy for more information.

THE BALLER LIFESTYLE PODCAST — EPISODE 603 Hosted by: Brian Beckner & Ed Daly Support the show: patreon.com/theballerlifestylepodcast FULL SHOW NOTES (APPLE PODCAST COMPREHENSIVE EDITION) Cold Open / Welcome Back Brian returns with Episode 603 of TBLS and immediately shouts out the Patreon crew—home of Bonus Bri, emotional sobriety updates, and all the private crying he refuses to do in public. Ed Daly joins and promptly delivers breaking news about an NFL player suspended for watching porn in a team meeting… at full volume. Chaos ensues. Thanksgiving Recap & Tea Talk Brian discovers green tea and is suddenly a Tea Guy. Ed forgets his tea entirely and feels betrayed. Listener debate begins: Should grown adults realistically be drinking gravy more than once a year? (The answer is apparently controversial.) ️ Woke Up Gay Again Mug Saga Brian receives a custom “Woke Up Gay Again” mug—plus his very own “gay card”—leading to: His daughter roasting him into dust. White pants discourse. Questions about whether the mug should be kept in his wallet for emergency resuscitation. ToeCutter strikes again. RIP Segment The boys honor (and roast) the deceased: Lynn Hamilton (Sanford & Son) Grandma the Galápagos Tortoise – lived 141 years, witnessed centuries of atrocities, said nothing. Randy Jones (Padres Cy Young winner, patron saint of 70s brown-and-yellow uniforms) Fuzzy Zoeller (apparently not 97 years old, though he looked it since 1997) ️ / Sports News Browns DL Shelby Harris calls 49ers WR Jauan Jennings a “hoe” And he clarifies it. Repeatedly. Patrick Beverley accused of punching and choking his teenage sister The guys discuss: Pat Bev's history of talking more than he plays The creepiness of men policing teenage girls' sex lives Whether Jay Stew thinks athletes should have podcasts (spoiler: he doesn't) Pickleball vs. Carmel, CA Carmel considers banning pickleball because it's “too noisy.” Brian rants about temporary courts, olds blowing Achilles tendons, and why tennis is superior. Drake Maye Spotted at His Girlfriend's Adult Cheer Competition Wait—adult cheer competitions? The guys spiral into: When activities should end What counts as “aging gracefully” The disturbing traditions of Texas A&M (midnight yell practice, dungarees, kick routines) Listener Voicemails & Mailbag Ben Astounded that Brian & Ed only consume gravy once a year. Matthew Richards Asks if Ed would peek at Hitler's infamous micro-penis if gifted a time machine. (Consensus: obviously yes.) Gfish Offers to file a complaint against Jay Stew's online bullies. Toe Cuttter Sends physical mail (!) including the mug and gay card, then demands: “Loudest Comer” rankings More show minutes A commitment to being “as gay as we want to be” Loudest Comer Power Rankings Chris Farley > John Belushi Dick Vitale > Harry Caray Air Bud Cinematic Universe: likely the evil clown, not Air Bud himself David Silver's mom (90210) receives an honorable mention Non-Sports: Weird News, Sexual Disasters & Political Horrors Hitler Micro-Penis Discourse Time travel urinal etiquette. Historical dick analysis. Rasputin's jar-encased hog. RFK Jr. Felching Poetry Scandal Brian & Ed read actual RFK sext-poems involving: “Harvests” “Canyons” “Don't spill a drop” Full-on National Institute of Health–certified felching definitions Listeners are begged to call in if they've ever actually felched (unlikely, but we're listening). UK Man Hospitalized After Eating 7 Pounds of Gummy Cola Bottles Relatable to a point. Then horrifying. Hugh Hefner reportedly drank 20 Pepsis a day + 3 lbs of M&Ms The true cause of Playboy longevity? Macaulay Culkin legally changes his middle name to Macaulay Culkin The poll results are honored. Italian Man Dresses as Dead Mother to Collect Pension Mrs. Doubtfire but make it mortifying. Smokey Robinson Accused of Forcing Strangers to Touch His Erection Brian plays tracks from GASMS, Smokey's actual album filled with sex songs to confirm: Yes, this man is capable of anything. SUPPORT THE SHOW Patreon subscribers get extended dong talk + bonus content weekly. Join here: patreon.com/theballerlifestylepodcast Hosted by Simplecast, an AdsWizz company. See pcm.adswizz.com for information about our collection and use of personal data for advertising.

Harvard president Alan Garber and National Institutes of Health head Jay Bhattacharya are two main characters at the heart of the national fight over the future of academia. Alan Garber has been cast as the defender of academic freedom and democracy; Jay Bhattacharya is Donald Trump's pick to lead the NIH, the agency withholding billions of dollars in research grants from Harvard. Oddly enough, the two men go way back: Garber was Bhattacharya's undergraduate thesis advisor and mentor in the late 1980s. This episode tells the story of how the two men found themselves adversaries — and what it means for the future of science. Find more On the Media every week, here: https://podcasts.apple.com/us/podcast/on-the-media/id73330715Learn more about sponsor message choices: podcastchoices.com/adchoicesNPR Privacy Policy