Podcasts about glom

ON EP132 Barrett sits down with rizing indie-shoegaze artist, Sean of GLOM. Where to follow  @newyorkglom  - WEB- https://glom.world/ SPOTIFY- https://open.spotify.com/artist/0OY528sf5HGsPB2xi8BJ4H APPLE- https://music.apple.com/us/artist/glom/1452934261 IG- https://www.instagram.com/newyorkglom/ TIKTOK- https://www.tiktok.com/@newyorkglom Like, Listen, Enjoy, Subscribe to the ATI Podcast anywhere you get your podcast audio. ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠https://flow.page/atipod⁠⁠⁠⁠⁠⁠⁠⁠⁠

New episode out now with ‪@newyorkglom‬!

3ème épisode / 5, de la série vascularites à ANCA Episode 3 : Le point de vue du Néphrologue. Invité : Pr Alexandre Hertig, néphrologue, chef du service de néphrologie de l'hôpital Foch à Suresnes et membre du conseil d'administration de la SFNDT, la Société Francophone de Néphrologie Dialyse et Transplantation. https://www.hopital-foch.com/offre-de-soins/nephrologie/     https://www.sfndt.org/    1️⃣   Qui sont les patients concernés par une atteinte rénale lors d'une vascularite à ANCA ? [0'27 – 0'46] ✔️La plupart des patients sont âgés de plus de 50 ans. Pour plus d'informations, retrouvez notre page article : https://rarealecoute.com/la-vascularite-a-anca/ 2️⃣   Comment se manifeste l'atteinte rénale et quand la soupçonner ? [0'47 – 1'44] ✔️ Hématurie avec protéinurie glomérulaire, ✔️ Glomérulonéphrite rapidement progressive. 3️⃣   Comment affirmer le diagnostic ? [1'45 -2'28] ✔️ Biopsie rénale montrant une glomérulonéphrite extra-capillaire pauci-immune. 4️⃣   Quel est le pronostic rénal des patients diagnostiqués ? [2'29 – 3'31] ✔️ Il dépend du nombre de poussées antérieures et de l'étendue des lésions rénales. 5️⃣   Quelle prise en charge rénale proposer ? [3'32 – 5'26] ✔️ Corticoïdes à forte dose, immunosuppresseurs... ✔️ Médicaments néphroprotecteurs. 6️⃣   Comment s'opère la coordination des soins les patients concernés ? [5'27 – 6'18] ✔️ Coopération néphrologues - médecins internistes.   L'équipe : Virginie Druenne – Ambassadrice RARE à l'écoute Cyril Cassard – Journaliste/Animation Hervé Guillot - Production Crédits : Sonacom ***************************************************************************************************************** À propos : "RARE à l'écoute" est un podcast dédié à la sensibilisation aux maladies rares et au soutien des personnes touchées par ces affections. Créé par un groupe passionné de professionnels de la santé, le podcast vise à informer les professionnels de santé et fournissant des informations sur les dernières avancées médicales et scientifiques dans le domaine des maladies rares, et inspirer les patients et leurs proches en partageant des histoires de courage et de persévérance. Contenu :

Lev is joined by Richie Redding and Danny Polishchuk! They talk about how Lev's weight loss challenge is going, "pager-gate", go-to Chipotle orders, and much more.The Lev Fer Show is a comedy podcast hosted by New York City comedian Lev Fer. Join Lev as he invites his favorite comedian friends on twice a week to chop it up and laugh about any and everything.Original Air Date: 9.18.24SEE LEV LIVEhttps://levfercomedy.com/LIVESTREAM Mondays & Fridays at 6:30PM E ONLY on GaS DigitalOr catch The YouTube Premiere the following Friday at 12PM Ehttps://GaSDigital.com/LIVESign up to the Gas Digital Network with promo code LEV and get a discount on your membership which includes access to full episodes of all our shows days before the public, FULL HD livestreams, join live chat, and the entire GaS Digital library, On-Demand and in HD!https://GaSDigital.comSUPPORT OUR SPONSORSGo to https://yokratom.com/ for the $60 kilo, no code needed!Go to https://yodelta.com/ and use code "GAS" for 25% off your order!FOLLOWThe Lev Fer Showhttps://instagram.com/levfershowLev FerInstagram: https://instagram.com/levferTwitter: https://twitter.com/thelevfershowDanny PolishchukInstagram: https://www.instagram.com/dannyjokes/Twitter: https://x.com/dannyjokesRichie ReddingTwitter: https://x.com/richiereddingInstagram: https://www.instagram.com/richiedoescomedy/#LevFer #GaSDigital #Podcast #ComedySee Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

The Dr. Phil (and obviously filtered and edited) interview of a convicted felon, the former President, Donald Trump, was predictably awful. Imagine 50-plus minutes of a man clearly in need of a psychologist, spewing lie after lie, laced with hyperbole and other half-truths, while the 'doctor" fails diagnose the chronically lying narcissist. You just come away convinced they're both facades; or at least it's now confirmed.

Johan and Andrew traveled last week to Austin, TX to celebrate the opening of Self Edge's newest location. While there, they took some time to sit down and chat about the city, their initial impressions of the store, and what Self Edge has meant to 3sixteen over the years. Andrew reflects on how partnering up at Self Edge over a decade ago helped informed 3sixteen's approach to retail. Johan shares about our recent warehouse move and another major one scheduled for this summer: a brand new storefront in Los Angeles.  Our theme music is by ⁠⁠⁠GLOM⁠⁠⁠. Follow 3sixteeen on ⁠⁠⁠Instagram⁠⁠⁠ | ⁠⁠⁠TikTok⁠⁠⁠ Follow Self Edge on Instagram | TikTok ⁠⁠⁠www.3sixteen.com

As our SS24 collection continues to roll out, Andrew sat down with 3sixteen's lead designer Wesley Scott to talk about the season and how it came together. Wesley's been with the company for almost a decade and we wanted to take time to share about his journey with the brand and how his approach has changed - but more importantly, how it's stayed the same. We touch on his time in grad school studying sustainability and how it means different things to different brands. And we close things out with the importance of bringing personal passion and taste into what we do at 3sixteen. Our theme music is by ⁠⁠GLOM⁠⁠. Follow 3sixteeen on ⁠⁠Instagram⁠⁠ | ⁠⁠TikTok⁠⁠ ⁠⁠www.3sixteen.com

#301Pothole RunNice Games Jam2023.04.21According to Minnesota Public Radio, it's hot girl sinkhole spring. In other words, we have an insane number of potholes right now in the Twin Cities, and since we can't do anything other than wait for the hardworking folks of road repair to fix them, we made a game about the whole situation. Andy and Beth Korth join for this special Nice Games Jam!GLOM preorder through Miniature MarketGLOM preorder through GameNerdz✨hot girl sinkhole spring✨ - Minnesota Public RadioUptown washout leaves 8-foot-deep sinkhole in Minneapolis intersection - Tim Nelson and Kerem Yücel, Minnesota Public RadioThe Korths are back! They were first on episode #002Steam GreenlightEpisode #102 with Beth & AndyCode Comment: "Verdant Skies"Episode #204 with Beth & AndyFamilies in GamesEpisode #132 with Beth Narrative Design An example of the pothole + sinkhole situation we're dealing with this spring.Another view of the school bus sinkhole.PromptEllen gave us a prompt: "Create a game about patching potholes that Gabe would have fun playing"Game typeTabletop gameMaterialsMarblesPlay-Doh or alternative squishynessA very complicated custom game boardRoad tiles of various sizes and configurationsSetupSet up the custom game boardDistribute marbles to all playersDistribute Play-Doh to all playersDistribute road / terrain tiles to all playersDetermine who will be the first player per the rules belowRulesIn a nutshell, the game challenges players to roll marbles down a hill. The hill is made of road tiles, but some of the tiles are pitted with potholes. Players can use Playdoh to patch potholes in the road so the marbles will make it to the finish.The board is a grid laid over a raised pyramid where players put down terrain. Everything starts in the center (city hall); that's where you put the marbles so they roll down the hill. Each quadrant is a side of the pyramid, there's some method of tiling for the player to put pieces down to determine how the marbles will travel in that area.Turn orderPlay starts with the player who most recently hit a pothole with their car or their bike. In case of a tie (as might happen if multiple players were in a car together), the younger player goes first.Play then proceeds clockwise.Players can take 3 actions on their turn. You can do the same action more than once. The actions are:Rotate the boardPlace or swap a tilePatch a potholeDrop a marbleTilesEach tile is worth 1, 2 or 3 victory points when marbles pass through. The rougher the tile, the more victory points it's worth.Players also get a bit of Play-Doh to fill up potholes in the terrain.Players have 5 tiles in their hand at any given time; as an action, they can play one, then draw back up to 5 tiles.Rotating the boardRotating the board happens towards the left (counterclockwise), the opposite of play order, which goes to the right (clockwise). Each rotation turns the board 90 degrees.Scoring & dropping marblesIf a marble reaches the bottom of the hill in front of you, you get the victory points that it acquired from each tile it moved through on its journey from the top of the hill to the bottom.You ONLY get the victory points if the marble reaches the bottom of the hill. If you drop a marble as an action, and the marble gets stuck on the way, you don't get any points from the tiles it passed through.Winning the gamePlay proceeds in 12 rounds. Each player gets one turn per round.Play ends when the turn counter reaches zero (game starts at the start of winter, ends at the start of the next winter)Whoever has acquired the most victory points by the end of the "year" is the winner of Pothole RunFun stuff to think about for the futureWe have to create an extractor to get the playdoh out.Cooperative play mode? Roles for each player? Someone who's better at filling potholes, someone who can put more marbles down, etc. Maybe two teams?

In this episode, Johan sits down with our good friend Josh Warner to chat about his journey towards creating Good Art. Josh shares about his upbringing and the joy of working with his hands from a young age, how loneliness breeds creativity, the benefits of ignorance and naïveté when it comes to starting your own company, and finding beauty in utility. Johan and Josh talk about our 20th anniversary collaboration and how it was a heavy project for Josh to take on because of his deep desire to honor the vision properly. We hope you enjoy the conversation. Our theme music is by ⁠⁠GLOM⁠⁠. Good Art ⁠⁠Website⁠⁠ | ⁠⁠Instagram⁠⁠ Follow 3sixteeen on ⁠⁠Instagram⁠⁠ | ⁠⁠TikTok⁠⁠ ⁠⁠www.3sixteen.com⁠

The clubhouse continues the annual tradition of reviewing the past year. But first they need to talk about Doctor Who and new Minnesota state flag. Ellen makes her first programming joke, and Dale learns to add comments from the editing booth.Finally, everyone shares which games they have been playing the bees out of in 2023.But, wait... there's more: your nice hosts also talk about what they are anticipating for 2024. Doctor WhoDonna Noble is the best companion - WikipediaCucumber, a miniseries by Russell T Davies - WikipediaIt's a Sin, a miniseries by Russell T DaviesMinnesota State FlagThe new Minnesota state flag - Briana Bierschbach, Star Tribune0:10:30Our accomplishmentsMark's Accomplishments:GlomDogpile!IGDA Twin Cities Calendar full of eventsIGDA Twin Cities's Playtest EventMaintenance of Noble EngineMajor Accomplishments in Dreamsettler including securing a big third party developer for a minigameStephen's Accomplishments:GlomFuture Club got funding to produce a vertical slice of a gameWorking on Future Club projects and pitching them (to a celebrity!)Survived a snake basement  Ellen's Accomplishments:GlomTWO custom game projects that Ellen is not allowed to talk aboutNoodle Training ArcadeSerious Play ConferenceGot a road bikeMoved to DuluthYour nice hosts talked about thier work as a tabletop development team in:The Nice Board Game Industrial Complex, a Nice Games Club Skunkworks ProjectMark gave a short presentation at the IGDATC holiday party about all the work that the group did in 2023.Ellen talks about her experience at the serious play conference in:Serious Play Conference SpecialMark talked about Noble Engine in:"So, you made a game engine?"0:29:11Nicest of 2023Ellen's Nicest:Baldur's Gate IIIKirby and the Forgotten LandNY Times Games App Magic the GatheringRival Stars Horse RacingGames from the Studio 'Afterburn'Mark's Nicest:Super Mario WonderSuper Nintendo WorldStar Trek: ResurgenceZachtronics Solitaire CollectionPuzzmoMark's Honorable Mentions:Spider Man 2Tears of the KingdomStar Trek: InfiniteStephen's Nicest:Spirit IslandForspokenDeceive, Inc.Stephen's Honorable Mentions:Tears of the Kingdom's Ascend abilityBaldur's Gate IIIMark mentioned what he usually calls "Super Mario Theme Park," which we talk about more in:GDC 2023 SpecialWe interviewed Zach of Zachtronic's Solitaire collection in Episode 293The Logistics of Moving OnPuzzmo is now publicly available!1:01:08Most Anticpated of 2024Ellen's picks:Hellblade II: Henua's SagaUltrosHyper Light BreakerLittle Kitty, Big CityDustbornConcordMark's picks:Paper Mario: The Thousand-Year Door remakePrincess Peach: Showtime!More Playdate games!Stephen's picks:Dragon's Dogma 21:16:132024 Gamedev ResolutionsEllen's Resolutions:Make stuffMake stuff in Godot EngineMake a portfolioDo less work, make more stuffUnpack some boxesMark's ResolutionsGet Dreamsettler outSet up future for Noble Robot officeSet up console SDK environments again for DS and others (Metro Nexus, porting work).Stephen's ResolutionsLook into game engines other than Unity

A few weeks back, Johan and Andrew took your question submissions via IG and answered them together after their 20th anniversary party in NY. They chat about what it was like to close up Wilson's after a wild month of service, design inspiration for seasonal collections, how to stay relevant with long-time and newer customers alike, and close out with some sneak previews on upcoming products and collaborations. A big thank you to our buddy Ryan Impulse for the photo from our 20th anniversary party. Our theme music is by GLOM.

The Truth Shall Make Ye Fret is a podcast in which your hosts, Joanna Hagan and Francine Carrel, read and recap every book from Sir Terry Pratchett's Discworld series in chronological order. This week, a special Double Feature (ooOOooh) featuring Marc Burrows and Jon Culshaw! We chat to Marc about the Edinburgh Fringe; his rave reviewed live show, The Magic of Terry Pratchett; and his ultra-exclusive Footnotes interviews.But wait, there's more! Marc has very kindly shared the audio from his interview with voice actor extraordinaire Jon Culshaw, star of the Watch arc in the new Discworld audiobooks. Hear about Culshaw's love for Discworld and the process of finding voices for Vimes, Vetinari, and various other Ankh Morporkian heroes.Find us on the internet:Twitter: @MakeYeFretPodInstagram: @TheTruthShallMakeYeFretFacebook: @TheTruthShallMakeYeFretEmail: thetruthshallmakeyefretpod@gmail.comPatreon: www.patreon.com/thetruthshallmakeyefretDiscord: https://discord.gg/29wMyuDHGP Want to follow your hosts and their internet doings? Follow Joanna on twitter @joannahagan and follow Francine @francibambi Things we blathered on about:LIVE DATES - The Magic of Terry Pratchett Buy Marc's books Glom of Nit - Substack Listen to Audiobooks narrated by Jon Culshaw - Audible.co.uk The Dark Room – Mr John Robertson Music: Chris Collins, indiemusicbox.com 

Andrew links up with Cam Niederhauser, owner of Kansas City-based retailer Guevel and proud new dad, to talk about his journey into fashion. They talk about his first job at Baldwin Denim, the resurgence of new American raw denim brands in the #menswear era, and how blogging about the clothing he loves eventually led to selling the clothing he loves. Tap in for some reminiscing on past eras of menswear, what Cam is excited about, and what his plans for Guevel are in the years ahead. Our theme music is by GLOM. Guevel Website | Instagram The Midwestyle Baldwin Denim Follow 3sixteeen on Instagram | TikTok www.3sixteen.com

Johan and Andrew sit down on the day of their first day of service at Wilson's, a cafe concept that 3sixteen has opened in their NYC flagship, and take time to reflect on what's gone into getting it off the ground and what they hope to achieve with it. Thanks to our buddy Herman Yung for the photo of us on our first day of service. Our music is courtesy of GLOM.

This week, Stephen and Ellen catch up with Mark about his (and Dale's) trip to GenCon. There is a happy minor Glom update, and then it's down to business. What's grind? What purpose does it serve, and what are the mechanics of it? Your nice hosts attempt to come up with some definitions & guidelines—you decide whether they succeed. And feel free to share your opinions on Discord :)Gen Con Grind 06:08 Ellen Burns-JohnsonGame DesignA Necessary Evil: Grinding in Games - Brice Morrison, Game Developer Emphasizing Uniqueness 26:32 Stephen McGregorMarketing

Merriam-Webster's Word of the Day for July 18, 2023 is: glom • GLAHM • verb To glom is to take or get something. Glom is most often used in the phrase “glom on to” to refer to taking something for your own use, becoming strongly attached to or associated with someone or something, or becoming aware of something. // The book consists of a collection of humorous essays glommed from popular magazines. // That author is known for glomming on to other people's ideas as if they were his own. // Other business owners have not yet glommed onto the impact the new parking garage will have on the town. See the entry > Examples: “I am aware that adaptations have been with us for centuries and that Shakespeare borrowed his best plots. But that doesn't stop this book lover from being suspicious when movies and plays glom onto my favorite titles.” — Chris Hewitt, The Star Tribune (Minneapolis, Minnesota), 21 May 2023 Did you know? It's a classic case of glomming: Americans seized on glaum (a term from Scots dialect that basically means “to grab”) and appropriated it as their own, changing it to glom in the process. Glom first meant “to steal” (as in the purse-snatching, robber kind of stealing), but over time that meaning got stretched to include figurative uses. Today the term is most familiar in the phrase “glom on to,” or “glom onto,” which can mean “to appropriate for one's own use,” as in “glomming on to another's idea”; “to grab hold of,” as in “glommed onto the last cookie”; “to latch on to,” as in “glom on to an opinion” or “glom onto an influential friend”; or “to become aware of,” as in “glomming onto the potential of this new technology.”

In this week's roundtable, Ellen needs help with ALL the things. Stephen and Mark offer advice on where to find people who can help, and discuss some of the hidden challenges of expanding one's team. Later, Stephen challenges everyone to think about how games can do a better job of implementing companion characters. Also, some host backstory tidbits, weird horse names, and (of course) a bit about Glom.Rival Stars: Horse Racing (the game that Ellen's playing) - PikPok, Google Play Store“What's your favorite commentary-friendly name?” - RedditAhead Of The Kentucky Derby, 5 Absurd Rules For Naming Racehorses (2015) - Julie Alderman, NPR Finding Help 0:11:46 Ellen Burns-JohnsonProductionHiring Game Designers - Game Developer Companion Characters 0:46:22 Stephen McGregorGame DesignGaming[The] 10 Best Companions In Gaming History - Jom Elauria, ScreenRant

(Some of) your nice hosts went to Origins Game Fair last week to check out the launch of their card game Glom. But before they went, they talked about the state of the next card game they're working on (and working on pitching to publishers), Dogpile!The Historical Legacy of Juneteenth - Smithsonian InstitutionW. E. B. Du Bois: A Resource Guide - Angela McMillian, Library of Congress The State of "Dogpile!" Mark LaCroixStephen McGregorEllen Burns-JohnsonIRLTabletopSell sheet for "Dogpile!"Rules document for "Dogpile!"Sell Sheets for Game Designers 101 - Luke Laurie, League of GamemakersCooper Black - Wikipedia Listen to us come up with the game in: Dogpile! We developed it further in: Dogpile! (part 2)‘Heroin for middle-class nerds': how Warhammer conquered gaming - Alex Hern, The Guardian

Your nice hosts return to form with a roundtable recorded together for the first time in a while! In this episode, Stephen sneaks a mini-topic in, Ellen asks some controversial questions and Mark helps us realize when we're breaking the law.As a side note, Glom is available right now! We've talked about it plenty on the show, but for more information or purchasing info you can go to nicegames.club/glom.Summer Games Done Quick 2023 - YouTube Licensing 0:10:27 Mark LaCroixIRLProductionA complete guide to font licensing for designers - Garrick Webster, Creative Bloq Cheating, Part 1 0:36:22 Ellen Burns-JohnsonGaming

After Mark's time with COVID, the first day he was free to go outside, the area was covered with the smoke of distant wildfires. Another bout of smoke has rolled in to the Twin Cities just in time for the release of this episode.The club spends this Nice Thinking episode talking about the making of Glom, and discussing their feelings about pitching and publishing board games. They discover that Mark and Stephen dread pitching, but Ellen thinks it can be fun (it's her superpower).This section is about Dale, who edited this episode.I did write most of the Glom cards, but that was really playing to my superpower of brainstorming lots of ideas, very quickly. The club mentioned...that I have a full time job - TRUE...that I have to deal with the club's crap - TRUE...cats - TRUE - I volunteer at a cat shelterFor 'Dogpile!' the game - I thought up 100 dog names - EASY and I have been thinking up ~20 cat names a week (my superpower right?)Finally, they share the story of how Mark no longer edits every episode, and that's how Dale got to title this episode and add a section of episode notes about cats.GLOMGlom launched on June 14th, 2023. It is available for purchase now!Our official Glom hompage.This section is about cats. It's kitten season and the cat shelters are full - please consider adopting a cat (or other animal, but you should really consider a cat or two). The city of Minneapolis Animal Care and Control has been waving cat adoption fees on select days. Minneapolis Pet Adoption If you choose a cat from Feline Rescue in Saint Paul, the name might have been suggested by Dale. Don't worry, you can promptly change their name to that of your favorite video game character. Feline Rescue Check out these two: Phobos and Deimos, named after the two moons of Mars (or Mario and Luigi if you prefer), they are available at the time of publication Deimos and Phobos, the moon brothers are available for adoption via this link Nice Thinking about our future in Board Games 0:04:40 IRLThe game GLOM Episode 210 is the NiceGames Jam that created Glom For the record, the third deck that was renamed goal, was originally called “Scoring System Deck.” We talked about pitching the game with Peter Yang in episode 231 Pitching Tabletop GamesWe're excited about 'Dogpile!' 'Dogpile!' was a game Jam from episode 272 Dogpile! And we did a followup in episode 275 Dogpile! (part 2) Nice Thinking about NiceGameJam Games with Potential 0:46:06 Game Design Mark's List of 5 Games 1. From episode 272, Dogpile! 2. From episode 275, Palace of Versailles 3. From episode 192, recorded live, Roboston! (parts 1 and 2) 4. From episode 157, Reravel: A Backwards Storytelling Game They also mention these GameJam Games: 6. From episode 134, Rules 7. From episode 143 Ants of Destiny: Morsels of the Queen Nice Thinking about traveling to conferences TabletopOrigins is June 21-25 2023 in Columbus OHGenCon is August 3-6 in Indianapolis, IN

The Break Room (THURSDAY 5/25/23) 7am Hour Includes:  1) Duffy and Tommy need to call out Kimmy for something she didn't do, but what happy to take credit for 2) If a large percentage of the population has a side hustle, why are so many of these types of jobs looked down upon? 3) The Rochester Amerks are currently the hottest ticket in town!

Your nice hosts explore the finality and the lusory this week with these two topics. In the process, Stephen struggles with a simple concept, Mark gets to 82% completion and Ellen figures out a way to blow up a transition.Glom is available for preorder! Find links here. Endings 0:13:40 Mark LaCroixGame DesignNarrative Lusory Attitude 0:38:51 Ellen Burns-JohnsonGamingIRLLusory Attitude - WikipediaLusory Definition - Merriam-Webster We bring up our Curling episode during this topic. "No referees?!"

According to Minnesota Public Radio, it's hot girl sinkhole spring. In other words, we have an insane number of potholes right now in the Twin Cities, and since we can't do anything other than wait for the hardworking folks of road repair to fix them, we made a game about the whole situation. Andy and Beth Korth join for this special Nice Games Jam!GLOM preorder through Miniature MarketGLOM preorder through GameNerdz✨hot girl sinkhole spring✨ - Minnesota Public RadioUptown washout leaves 8-foot-deep sinkhole in Minneapolis intersection - Tim Nelson and Kerem Yücel, Minnesota Public Radio The Korths are back! They were first on episode #002 Steam Greenlight Episode #102 with Beth & Andy Code Comment: "Verdant Skies" Episode #204 with Beth & Andy Families in Games Episode #132 with Beth Narrative Design An example of the pothole + sinkhole situation we're dealing with this spring. Another view of the school bus sinkhole. Prompt Ellen gave us a prompt: "Create a game about patching potholes that Gabe would have fun playing" Game type Tabletop game Materials MarblesPlay-Doh or alternative squishynessA very complicated custom game boardRoad tiles of various sizes and configurations Setup Set up the custom game boardDistribute marbles to all playersDistribute Play-Doh to all playersDistribute road / terrain tiles to all playersDetermine who will be the first player per the rules below Rules In a nutshell, the game challenges players to roll marbles down a hill. The hill is made of road tiles, but some of the tiles are pitted with potholes. Players can use Playdoh to patch potholes in the road so the marbles will make it to the finish.The board is a grid laid over a raised pyramid where players put down terrain. Everything starts in the center (city hall); that's where you put the marbles so they roll down the hill. Each quadrant is a side of the pyramid, there's some method of tiling for the player to put pieces down to determine how the marbles will travel in that area.Turn orderPlay starts with the player who most recently hit a pothole with their car or their bike. In case of a tie (as might happen if multiple players were in a car together), the younger player goes first.Play then proceeds clockwise.Players can take 3 actions on their turn. You can do the same action more than once. The actions are:Rotate the boardPlace or swap a tilePatch a potholeDrop a marbleTilesEach tile is worth 1, 2 or 3 victory points when marbles pass through. The rougher the tile, the more victory points it's worth.Players also get a bit of Play-Doh to fill up potholes in the terrain.Players have 5 tiles in their hand at any given time; as an action, they can play one, then draw back up to 5 tiles.Rotating the boardRotating the board happens towards the left (counterclockwise), the opposite of play order, which goes to the right (clockwise). Each rotation turns the board 90 degrees.Scoring & dropping marblesIf a marble reaches the bottom of the hill in front of you, you get the victory points that it acquired from each tile it moved through on its journey from the top of the hill to the bottom.You ONLY get the victory points if the marble reaches the bottom of the hill. If you drop a marble as an action, and the marble gets stuck on the way, you don't get any points from the tiles it passed through.Winning the gamePlay proceeds in 12 rounds. Each player gets one turn per round.Play ends when the turn counter reaches zero (game starts at the start of winter, ends at the start of the next winter)Whoever has acquired the most victory points by the end of the "year" is the winner of Pothole RunFun stuff to think about for the futureWe have to create an extractor to get the playdoh out.Cooperative play mode? Roles for each player? Someone who's better at filling potholes, someone who can put more marbles down, etc. Maybe two teams?

The year 2022 in review! Yes, it's now halfway through February, but being a few weeks late is part of the annual "Nicest Of" tradition. Your hosts (plus guest Holly Harrison) revisit their notable games and goals from 2022, and make some plans for 2023.Holly is here in the clubhouse for this recording!Things that happened in 2022: We sold GLOM! It's coming out in 2023.Mark announced a game (Dreamsettler) and released Noble Engine for the PlaydateStephen became a co-owner of Future ClubEllen got a new job as a game designer with The Game AgencyHolly moved into a new place—one without unwanted insects and thieving neighbors Nicest of 2022 0:04:56 Mark LaCroixStephen McGregorEllen Burns-JohnsonHolly HarrisonGamingEllen's Nicest:Metroid: DreadFlappy DragonBanner Saga 1Endling: Extinction is ForeverMark's Nicest:Mario + Rabbids: Sparks of HopeStrayLast Call BBSStephen's Nicest:Kirby and the Forgotten LandSplatoon 3RumbleverseSpirit IslandHolly's Nicest:OobletsSplatoon 3Bear and BreakfastCult of the LambSlime Rancher II Most Anticipated of 2023 0:49:28 Mark LaCroixStephen McGregorEllen Burns-JohnsonHolly HarrisonGamingEllen's picks:Mars First LogisticsBanner Saga II and IIIOri and the Will of the WispsSlime Rancher IICyberpunk 2077Mark's picks:Horizon: Call of the Mountain on Playstation VR 2Assassin's Creed: MirageSeason: A Letter to the FutureDreamsettlerStephen's picks:Dragon's Dogma IIStreet Fighter 6Holly's picks:Mineko's Night MarketThirsty SuitorsHades IISea of StarsPicked by everyone:The Legend of Zelda: Tears of the Kingdom

Linktr.ee/NermerNermerBecome a patron at Patreon.com/NermerNermerThe clickbait article in question: https://www.heraldweekly.com/travolta-breaks-silence/2/?xcmg=1

Take some time for yourself. Get some Space. Be free. Look out for other people. Help whereever you can. Spend time listening to people. Thanks for listening to this show... here is some new original independent music for you! Always...Commercial free..ok papa Please enjoy..JB

As broadcast November 1, 2022 with(out) our main girl but we keep on keepin' on.  Tonight we open spotlighting Kurt Cobain and Nirvana finally releasing their stellar MTV Unplugged album on this date in 1994 while spotlighting some of the emotions and states we're all in right now in the horrific afterglow of Saturday's tragedy.  If you're suffering from survivor's guilt or any mental health issues resulting from this event, even if you weren't there, there are resources out there (and we'd be happy to provide them if anyone reaches out).  Kat Bass was once again not in the studio this week, but was ready with the playlist and tunes for our indie weekly.  Highlights from COOL HEAT, SURL, The Hails, and Daisy the Great feature throughout, along with of course a slew of other worthy artists to check out.#feelthegravityTracklist (st:rt)Part I (00:00)Nirvana – All Apologies (Unplugged)Field Guide – Worst of WaysPhoebe Go – Be the Player, Not the PoetDaisy the Great – Time MachineUS Girls – Bless This MessTeenage Priest – Victory Lap Chelsea Days – It GoesPart II (36:21)Kailee Morgue - Cheerleader girlpuppy - Permanent State The Hails - Exonerate Softlander - Angel Vibropath - OverboardJude Shuma - Working So Hard Glom – Pebble Part III (68:40)Kitchen - River Song Masaki Suda & sooogood! - Ai to uno Paige ft. Ant Saunders - Miles Away Skinshape - Better ChancesSURL - Walking in DreamOrchid Mantis- I Could Live in Sleep S.C.A.B – Small Talk Part IV (1:43:01)Spirit Ghost - I Prayed Morning Silk - So FunOberhofer - Let It Go (Demo) COOL HEAT - Forget Asian Glow ft. Bomul - Huddle Formation Hotel Fiction - Monster Rebounder – Factoury Girl

As triggered on air September 20, 2022.  Tonight we rebrand our weekly traipse through The Great Indie Truffle Forest by rebranding it Triggered, because since Kat Bass arrived a year ago, there's just been way too much hyperventilation and eyes agog too numerous to take full account of.  A great start to season 8 for our indie show, with new tunes out from big time favorites of the show along with our special guest for Friday night Say She She!  (Speaking of hyperventilation)  Other highlights from Human Barbie, JW Francis, Sure Sure, and many more to taste test and make sure everything is just right for your discerning new music palette.#feelthegravityTracklist (st:rt)Part I (00:00)The Byrds – Goin' BackHuman Barbie – purple and redBEACHPEOPLE – fugazi.com – Lover for TonightSay She She – PrismSay She She – Lover for TonightPart II (32:37)Jeremy Zucker ft. BENEE - I'm So Happy* O.WHEN - better now easy life & Gus Dapperton - ANTIFREEZE MAX ft. keshi - IT'S YOU Sure Sure - 123 Good Wilson - Will It Ever Stop Part III (59:42)JW Francis - I Wanna Be Your BasketballPreloved - Turn Me RoundMidi Memory - Internal Dream The Plastic Cherries - Lovers On The Run Glom - 12:21  The Academic - Don't Take It Personally Part IV (90:06)chilldspot - Like? Nerd Connection - Pablo Daya - New Romantics Blood Orange ft. Erika De Casier & Eva Tolkin - Relax and Run Josephine Odhil - Familiars The Black Skirts - John Fry 

Hierarchical Polyamory is one of the most commonly practiced forms of poly out there! With that comes a lot of room for error and even more room for improvement, especially when it comes to checking yourself on how healthy and ethical your hierarchical dynamic is! Because unchecked hierarchical poly has a sinister evil twin... the GLOM! We're going to explore if ethical hierarchy is possible, what egalitarian poly is, and how to practice hierarchical polyamory in a way that keeps the glom away! Loving our podcast as much as we love making it? PLEASE go leave a review for us on Apple

#240 Sledgehammer BrideNice Thinking 2021.10.28 It's Stephen's turn at Nice Thinking, our new episode format where we brainstorm around a single concept someone brings into the clubhouse. Get ready for your first contact with the Sledgehammer Bride!Glom will be part of Wordplay 2021, November 13-14 - Hand Eye Society Sledgehammer Bride Stephen McGregorGame DesignNarrativeA Brief History of Beat 'em Up Video Games - Hero ConceptProspective Teachers Misperceive Black Children as Angry  - Bryan Goodman, American Psychological AssociationThe Brute Caricature - History on the NetExamining Game Pace: How Single-Player Levels Tick - Mark DaviesShank 2 - Klei Entertainment, SteamHow the Original Hyrule Warriors Broke The Mold for Musou Games Forever - Dale Bashir, IGN

#240 Sledgehammer BrideNice Thinking 2021.10.28 It's Stephen's turn at Nice Thinking, our new episode format where we brainstorm around a single concept someone brings into the clubhouse. Get ready for your first contact with the Sledgehammer Bride!Glom will be part of Wordplay 2021, November 13-14 - Hand Eye Society Sledgehammer Bride Stephen McGregorGame DesignNarrativeA Brief History of Beat 'em Up Video Games - Hero ConceptProspective Teachers Misperceive Black Children as Angry  - Bryan Goodman, American Psychological AssociationThe Brute Caricature - History on the NetExamining Game Pace: How Single-Player Levels Tick - Mark DaviesShank 2 - Klei Entertainment, SteamHow the Original Hyrule Warriors Broke The Mold for Musou Games Forever - Dale Bashir, IGN

#210 GlomNice Games Jam 2021.03.31 This week your nice hosts have a rowdy game jam. Dale gave us a prompt: Create a matching game with a puzzle element. The puzzle must be "what matches first" and bonus points if there's cats.The goal of every Nice Games Jam is for the team to come up with a playable game by the end of the episode. Did Stephen, Mark, and Ellen make it happen, or did they end up with a pile of nonsense? Well, maybe a bit of both.The "dot game" that Ellen referenced is called Dots & Boxes - Wikipedia A three-sided die similar to the one that Eric, Ellen's partner, owns. Here's a place you can buy your own three-sided die - Nvenom8 Designs on ShapeWays Marketplace Game type Tabletop game Player count Any Materials Paper, pencil or pen Setup Each player should have:Paper (or someplace to compose sentences)Something to write with (typing on a screen is fine)Some way of indicating points passed to other players (chips, coins, etc.) -- in the rules below, these will be referred to as "chips"The game requires three decks. As of this airing, each deck has three cards:Prompts deck "Nice to meet you.""Where is the bathroom?""Can I pet your cat?"Constraints deck No letter Es (this is incredibly difficult)Exactly 4 wordsOnly single-syllable wordsScoring deck Most wordsMost lettersLongest word in the sentence Rules The goal of the game is to acquire the most points out of all the players.Players acquire points by writing sentences that adhere to the Prompt, Constraint, and Scoring card drawn for each round.SetupShuffle all three decks.Distribute chips evenly amongst all players.Starting a RoundDraw a single card from each deck. Place all three face-down on the table.Set the timer for the desired duration: 1 minute, 2 minutes (default) or 3 minutes.Flip all three cards face-up and start the timer.All players then attempt to compose a sentence that meets the criteria of all three cards (Prompt, Constraint, and Scoring) within the time limit.Share Your SentencesEach player speaks their sentence aloud. (If you're playing online, you can also enter your sentence into the text chat.) The sequence in which players share their sentences doesn't matter—just be nice about it.Round ScoringPlayers can't use any of the words in the phrase on the Prompt card. There's a penalty (-1 point) for each word used. Exception: You can use the same spelling of a word if it's another type of word (noun vs. verb) Alternate rule for extra challenge and silliness: Remove the exception to the above rule.The player whose sentence meets the conditions on that round's Scoring card wins 3 points.Players pass one of their chips to the person who had, in the player's opinion, the coolest sentence. This is a subjective judgment and has nothing to do with the rules. Each chip received counts as 1 point for the receiving player.DisputesDuring Round Scoring, any player can raise an argument about how the rules apply to another player's sentence. If you bring an argument, you have to propose a resolution, and people will vote on the proposal. (For example, you can propose a change to someone's point total that round, or suggest a change to a person's sentence to bring it within the rules.) If the vote passes, the solution goes through.Continue Play and End the GameFor each subsequent round of play, draw a new set of cards. Play and score according to the above rules.The game ends when all Prompt cards have been used. Shuffle Constraints and Scoring cards back into their respective decks as needed.The player with the most points wins!

#210 GlomNice Games Jam 2021.03.31 This week your nice hosts have a rowdy game jam. Dale gave us a prompt: Create a matching game with a puzzle element. The puzzle must be "what matches first" and bonus points if there's cats.The goal of every Nice Games Jam is for the team to come up with a playable game by the end of the episode. Did Stephen, Mark, and Ellen make it happen, or did they end up with a pile of nonsense? Well, maybe a bit of both.The "dot game" that Ellen referenced is called Dots & Boxes - Wikipedia A three-sided die similar to the one that Eric, Ellen's partner, owns. Here's a place you can buy your own three-sided die - Nvenom8 Designs on ShapeWays Marketplace Game type Tabletop game Player count Any Materials Paper, pencil or pen Setup Each player should have:Paper (or someplace to compose sentences)Something to write with (typing on a screen is fine)Some way of indicating points passed to other players (chips, coins, etc.) -- in the rules below, these will be referred to as "chips"The game requires three decks. As of this airing, each deck has three cards:Prompts deck "Nice to meet you.""Where is the bathroom?""Can I pet your cat?"Constraints deck No letter Es (this is incredibly difficult)Exactly 4 wordsOnly single-syllable wordsScoring deck Most wordsMost lettersLongest word in the sentence Rules The goal of the game is to acquire the most points out of all the players.Players acquire points by writing sentences that adhere to the Prompt, Constraint, and Scoring card drawn for each round.SetupShuffle all three decks.Distribute chips evenly amongst all players.Starting a RoundDraw a single card from each deck. Place all three face-down on the table.Set the timer for the desired duration: 1 minute, 2 minutes (default) or 3 minutes.Flip all three cards face-up and start the timer.All players then attempt to compose a sentence that meets the criteria of all three cards (Prompt, Constraint, and Scoring) within the time limit.Share Your SentencesEach player speaks their sentence aloud. (If you're playing online, you can also enter your sentence into the text chat.) The sequence in which players share their sentences doesn't matter—just be nice about it.Round ScoringPlayers can't use any of the words in the phrase on the Prompt card. There's a penalty (-1 point) for each word used. Exception: You can use the same spelling of a word if it's another type of word (noun vs. verb) Alternate rule for extra challenge and silliness: Remove the exception to the above rule.The player whose sentence meets the conditions on that round's Scoring card wins 3 points.Players pass one of their chips to the person who had, in the player's opinion, the coolest sentence. This is a subjective judgment and has nothing to do with the rules. Each chip received counts as 1 point for the receiving player.DisputesDuring Round Scoring, any player can raise an argument about how the rules apply to another player's sentence. If you bring an argument, you have to propose a resolution, and people will vote on the proposal. (For example, you can propose a change to someone's point total that round, or suggest a change to a person's sentence to bring it within the rules.) If the vote passes, the solution goes through.Continue Play and End the GameFor each subsequent round of play, draw a new set of cards. Play and score according to the above rules.The game ends when all Prompt cards have been used. Shuffle Constraints and Scoring cards back into their respective decks as needed.The player with the most points wins!

The Feelies made their triumphant return to the live stage on November 6th! We previewed their gig at White Eagle Hall that evening with a couple of deep cuts from their 1991 album, Time For A Witness, and their 2011 record, Here Before. We also celebrated the anniversary of Living In Fear, the awesome record from CR and the Nones in honor of its first birthday. Plus, we spun a ton of great local jams from Fiona Silver, Bummer Camp, T.V.O.D., The Rizzos, Hot Tea, Razor Braids. Laurel Canyon, Wetsuit, GLOM, Habibi, Sub*T, and more. Playlist: The Feelies "Invitation" from Invitation The Feelies "Should Be Gone" from Here Before on Bar/None Records CR and the Nones "The Back Door" from Living in Fear on Favorite Friend Fiona Silver "Swoon" from Swoon - Single Bummer Camp "Gone Rotten" from Gone Rotten - Single on 984442 Records DK2 TVOD "Midwestern Hero" from Victory Garden on Bleecker Boyz Recods The Rizzos "Breslin" from Breslin - Single Hot Tea "Quit Your Job" from Quit Your Job - Single Razor Braids "Don't Stop!" from Don't Stop! - Single Laurel Canyon "Victim" from Victim - Single on Laurel Canyon Wetsuit "Sticky Sweet" from Sticky Sweet - Single on Wetsuit Glom "She Has Made It to the Other Side" from She Has Made It to the Other Side - Single on La Reserve Records Habibi "Call Our Own" from Somewhere They Cant Find Us b/w Call Our Own - Single on Kill Rock Stars Sub*T "Table For Four"

This the Off Season Vol. 1 | Rell recaps seasons 1 through 4 of Insecure with Glom; the two got into how they bottom as woman and man connected to this Black millennial show...listen if you've watched Insecure over the seasons then you know what we've received on screen is a series of reflections and lessons. This is the recap to pass to your friends. Check it out! Email - everybodymadpod@gmail.com Apple - Everybody Mad Google - Everybody Mad Spotify - Everybody Mad Everybody Mad Site | Instagram - EverybodyMadPod | SheGlowz88 Facebook Page - Everybody Mad |

It's Stephen's turn at Nice Thinking, our new episode format where we brainstorm around a single concept someone brings into the clubhouse. Get ready for your first contact with the Sledgehammer Bride! Glom will be part of Wordplay 2021, November 13-14 - Hand Eye Society Sledgehammer Bride Stephen McGregor Game Design Narrative A Brief History of Beat 'em Up Video Games - Hero Concept Prospective Teachers Misperceive Black Children as Angry  - Bryan Goodman, American Psychological Association The Brute Caricature - History on the Net Examining Game Pace: How Single-Player Levels Tick - Mark Davies Shank 2 - Klei Entertainment, Steam How the Original Hyrule Warriors Broke The Mold for Musou Games Forever - Dale Bashir, IGN

For this episode, I spoke with Sean and Peter of the New York alternative rock project GLOM, an outfit known for a fuzzy instrumental disposition, one that belies a humanistic, and occasionally spiritual, lyrical content. It's a quality that I enjoy in particular about GLOM as a band—that's there's far more happening below the surface meriting a deep dive, facets of generally sunny music that obscure something deeper. To that end, we spoke at length about the tracks on their most recent effort Merit, the capitalist hellscape we all reside within, the band's predisposition towards four-letter words, and Wes Anderson. TRACKS FEATURED: She Has Made It to the Other Side 1221 FOMO Follow GLOM: https://newyorkglom.bandcamp.com/ www.instagram.com/newyorkglom Produced, mixed, and edited by Billy Coughlin (aka Bilco): instagram.com/bilco_bops Hosted by Connor Beckett: twitter.com/b_ck_tt instagram.com/b_ck_tt Follow LOCAL BOPS:
 localbops.com
 instagram.com/localbopsnyc www.patreon.com/localbopsnyc

This month we talk to Glom Press, an award winning indie publisher of comics from Melbourne. How did an indie publisher of Australian comics come to be? What's indie publishing like? And much more is covered. To find out more about Glom Pres and their work visit their website: https://www.glompress.comIf you like what we're doing, hit the subscribe button to stay up to date. You can also follow us on Twitter: https://twitter.com/ALIAGraphic​ and check our blog, https://aliagraphic.blogspot.com​, for updates, monthly roundups of news and new release titles. Hosted on Acast. See acast.com/privacy for more information.

 This month we talk to Glom Press, an award winning indie publisher of comics from Melbourne. How did an indie publisher of Australian comics come to be? What's indie publishing like? And much more is covered. To find out more about Glom Pres and their work visit their website: https://www.glompress.comIf you like what we're doing, hit the subscribe button to stay up to date. You can also follow us on Twitter: https://twitter.com/ALIAGraphic​ and check our blog, https://aliagraphic.blogspot.com​, for updates, monthly roundups of news and new release titles.

It's a packed clubhouse for this special episode! Your regular hosts are joined by two guests: Peter Yang and Dale LaCroix. Peter is a game designer, creative director, and tabletop games agent based out of Minnesota. Dale, as you know, is just plain evil. The adventure of the day—pitching games to tabletop publishers. And Peter is our guide! Pitching Tabletop Games MarketingPhysical GamesTabletopListen to the episode where GLOM first took shape (episode 210).GlomProtospiel MN (2020)Twin Cities Playtest with IGDA-TCGenConOrigins Game FairTabletop Simulator - notes on importing cards - Dale LaCroixThe Game Crafter - Print cards on demand with this websitePeter YangGuestPeter's a charismatic public speaker with a passion for games and game development. He's worked in QA, development, and production roles within the games industry. From board games to video games, he enjoys helping people bring their fun ideas to stand out from the crowd. External link Peter on Twitter @ZettoVyker

It's a packed clubhouse for this special episode! Your regular hosts are joined by two guests: Peter Yang and Dale LaCroix. Peter is a game designer, creative director, and tabletop games agent based out of Minnesota. Dale, as you know, is just plain evil. The adventure of the day—pitching games to tabletop publishers. And Peter is our guide! Pitching Tabletop Games Marketing Physical Games Tabletop Listen to the episode where GLOM first took shape (episode 210). Glom Protospiel MN (2020) Twin Cities Playtest with IGDA-TC GenCon Origins Game Fair Peter Yang Guest Peter's a charismatic public speaker with a passion for games and game development. He's worked in QA, development, and production roles within the games industry. From board games to video games, he enjoys helping people bring their fun ideas to stand out from the crowd. External link Peter on Twitter @ZettoVyker

In this episode I have a really interesting conversation with Karan Grewal, member of the research staff at Numenta where he investigates how biological principles of intelligence can be translated into silicon. We speak about the thousand brains theory and why neural networks forget.     References Main paper on the Thousand Brains Theory: https://www.frontiersin.org/articles/10.3389/fncir.2018.00121/full Blog post on Thousand Brains Theory: https://numenta.com/blog/2019/01/16/the-thousand-brains-theory-of-intelligence/ GLOM paper by Geoff Hinton: https://arxiv.org/pdf/2102.12627.pdf Why neural networks forget? https://numenta.com/blog/2021/02/04/why-neural-networks-forget-and-lessons-from-the-brain  

The exciting conclusion to Chapter Two: Renal Circulation and Glomerular Filtration Rate - Determinants of GFR - First step in making urine is separation of an ultrafiltrate - Governed by starling forces - Balance of hydraulic and osmotic forces - GFR = LpS (P gc – P us - Osmotic Pressure Cap p) - Normal GFR 95 in women, 120 in men - Cap Hydrolic pressure remains constant - glom cap Oncotic progressively rises - Due to filtration of protein free fluid (protein concentration rises in the capillary) - Filtration gradient begins at 13 mmHg and falls to zero after filtration of 20% or RPF! - GFR is capped at 20% of RPF called filtration equilibrium - So GFR is dependent on RPF, unless you can change glomerular hydraulic pressure - Glomerular hydraulic pressure is controlled by balance of twin arteriole (afferent and efferent) - Constriction of afferent arteriole reduces RPF, GFR, and glom pressure - Dilation of afferent arteriole increases RPF, GFR, and glom pressure - Constriction of the efferent arteriole increases Glom pressure, increasing GFR - Besides glom hydrostatic pressure the other starlings forces are rarely relevant to changes in GFRLetty says: referred to this NEJM review article later JC thought she was referring to something else -see #2- and then Roger referred to this again)Normotensive Acute Renal Failure from Gary Abuelo in NEJM 2007. https://www.nejm.org/doi/10.1056/NEJMra064398 (note in this article, Dr. Abuelo acknowledges the newer terminology of the time, AKI rather than ARF but chooses not to embrace it). In figure 2, he highlights the classic examples of how autoregulation can be affected. In the table, additional examples are provided but all within the framework of alterations related to autoregulation and the interplay between the two resistance vessels.- Regulation of GFR - Autoregulation - The ability to keep glomerular pressure constant over wide range of systemic arterial pressure - When pressure < 70 autoregulation fails and GFR will fall with decreases in systemic pressure - When pressure falls below 40-50 GFR ceases - At least some of this autoregulation is mediated with Ang2. Giving ACEi markedly disrupts autoregulation - Nitric oxide, not important - TGF - Chloride in macula densa - Blocked by furosemide - Group affect of nephrons - Ang 2 sensitizes - Adenosine mediates - Function of TGF - 90% of filtrate is reabsobed in PT and LOH - 10% is reabsobed dismally - Need to control the amount of fluid delivered distally to prevent overwhelming the resorptive capacity of the distal nephron - Talks about acute renal success without naming it (but did reference it) - Mentions glucosuria blunts TGF. Hmmm... - Neurohormonal influences - Volume changes in ang2, sympathetic NS - Role of PGE - Interesting discussion of change of the nephrons perfumed with volume depletion, shifting of blood from outer coretex to inner medullary cortical gloms with their long loops - Dopamine and ANP both increased with volume up - Dopamine causes vasodilation of afferent and efferent arteriole - ANP causes afferent vasodilation and efferent vasodilation constriction, increasing GFR without affecting RPF - Glomerular hemodynamics and renal failure - Decreased glomerular mass results in hyperfiltration of remaining gloms - Mediated through afferent vasodilationJC talks about this classic study in critical care: High vs. Low blood pressure target in Septic Shock. https://www.nejm.org/doi/pdf/10.1056/NEJMoa1312173In this multi-center open label trial of 776 patients randomized to either a MAP of 65-70 or 80-85 with the primary endpoint of mortality. There was no difference in mortality at 28 days between the two groups (but a small difference in AKI in the patients who had chronic HTN- in the higher BP target, there was a decrease in need for RRT; there was also a higher incidence of afib in the high target group overall). - Results in compensation and stable GFR in short term, long term maladaptive - Reason for ACEi- Clinical Evaluation of Renal Circulation - Concept of clearance and measurement of GFR - GFR as an index of functioning renal mass - Had a patient today s/p nephrotomy, 72 years old, Cr0.9!Melanie referred to this article in Circulation which demonstrates that SGLT2 inhibitors do decrease single nephron GFR (in mice) and that this is related to a decrease in the afferent arteriole diameter and then they show that this is related to a local increase in adenosine. Kidokoro K, Cherney DZI et al. Evaluation of glomerular hemodynamic function by empagliflozin in diabetic mice using in vivo imaging Circulation 140 (4) 2019https://www.ahajournals.org/doi/10.1161/CIRCULATIONAHA.118.037418 - Fall in GFR earlier and only sign of renal disease - Serial monitoring is used to assess severity and follow the course of disease - GFR is useful for dosing drugs - How to measure GFR - Consider fructose polysaccharide inulin (love the parenthetical, not insulin) - Inulin filtered = inulin excreted - Filtered inulin = plasma inulin concentration x GFR - Inulin excreted = urine concentration x urine volume - Use Alber a to get GFR = [Urine]insulin x urine volume / [plasma]inulin - GFR = inulin clearance - There is not an available assay for inulin - Creatinine clearance - Freely filtered - Not reanbsorbed - Not metabolized - Small amount excreted - CrCl exceeds GFR by 10-20%Roger says the SGLT2 inhibitor story is about the afferent arteriole and he thought it reminded him of the MDRD study and the concept that the lower protein intake would be protective and delay the progression of CKD. The concept was that low protein diets would decrease glomerular pressure by decreasing the intake of amino acids that lead to arteriolar vasodilation and increased GFR. Klaur S, Levey AS et al. The effects of Dietary Protein Restirciton and blood-pressure control on the progression of chronic renal disease. NEJM 1994 330:877-884. https://www.nejm.org/doi/full/10.1056/nejm199403313301301 - Compensated for by noncreatinine chromogens (acetone proteins, as Orbi acid, pyruvate) that over estimate Cr by 10-20% - Cr Cl = [Urine]cr x urine volume / [Plasma]cr - Two major limitations - Incomplete collections - 20-25 mg/kg in adult men - 15-20 mg/kg in adult womenThe term “Acute renal success” comes from Thurau K and Boylan JW. Acute renal success. The unexpected logic of oliguria in acute renal failure. Am J Med 1976 61(3): 3038-15. - Falls by 50% from age 50 to 90 to 10 mg/kg - Increased tubular secretion with decreased kidney function - GFR of 40-80 cr secretion may account for as much as 35% of creatinine excretion - In some cases CrCl can exceed GFR by a factor of 2 - Give cimetidine 1200 mg! - It is important to appreciate however that exact knowledge of GFR is not required. More important to know if GFR is changing - Why is radio labeling the solution DTPA and iothalamate? - Talks about the reality of progressive disease despite stable GFR and CrCl - On to plasma Cr and GFRIf you think placing dialysis lines is too easy, here is a wonderful review of micropuncture technique in the kidneys by Volker Vallon.Micropuncturing the Nephron. Pflugers Arch 2009 458(1): 189-201. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2954491/ - Creatinine excretion = creatinine production (and this is constant) - Creatinine excretion = [Cr] x GFR = constant - If GFR falls in half, creatinine excretion will fall in half, while creatinine production remains the same, so creatinine will rise and rise until [Cr] x GFR = creatinine production and then it will level off. - Changes in creatinine load - High protein diet can increase it - Vegetarian diet can decrease itJC brought up studies on fenoldopam, of which there are many. This is one such study in patients undergoing cardiac surgery. JAMA 2014 Bove T et al. Effect of fenoldopam on use of renal replacement therapy among patients with acute kidney injury after cardiac surgery: a randomized clinical trial https://pubmed.ncbi.nlm.nih.gov/25265449/ - Cooked meat can increase Cr by 1 mg/dL - Talks about need for steady state to assess GFR - Talks about the curvilinear relationship - Then he talks Cockcroft GaultThe one, the only: The Cockcroft Gault: Prediction of creatinine clearance from serum creatinine. Nephron 16: 31–41, 1976 https://pubmed.ncbi.nlm.nih.gov/1244564/ - Cirrhosis masks kidney insufficiency, low meat intake, low BUN production - Can someone explain what we are supposed to take from figure 2-12 - Stable Cr does not mean stable kidney diseaseRoger describes the study design for the seminal paper on the use of ACE inhibitors to slow the decline in renal function in diabetic kidney disease (then called diabetic nephropathy) and the decision to use the doubling of the serum creatinine as an endpoint. Lewis EJ The effect of Angiotensin-converting-enzyme inhibition on diabetic nephropathy NEJM 1993 https://www.nejm.org/doi/full/10.1056/NEJM199311113292004 - Ketoacidosis can raise the Cr 0.5 to 2.0mg/dL - On to BUN - Destination of amino acids produces ammonia - We detoxify ammonia by converting to urea - Increased with increased protein load - Increased catabolismMelanie mentioned an old study on ingestion of expired blood: Cohen TD. Induced azotemia in humans following massive protein and blood ingestion and the mechanism of azotemia in gastrointestinal hemorrhage. AM J Med Sci 1956 https://pubmed.ncbi.nlm.nih.gov/13302213/ - Tetracycline causes decreased anabolism - Trauma - Steroids - Urea excretion is variable and tied to hydration and FF - Renal plasma flow and PAH

Our intrepid adventurers discover that the only thing that makes a rose beautiful is that the rose's beauty is fleeting.    Music from https://filmmusic.io: "Enter the Maze" by Kevin MacLeod (https://incompetech.com) Licence: CC BY (http://creativecommons.org/licenses/by/4.0/) Music from https://filmmusic.io: "Future Gladiator" by Kevin MacLeod (https://incompetech.com) Licence: CC BY (http://creativecommons.org/licenses/by/4.0/) Music from https://filmmusic.io: "Ready, Aim, Fire!" by Kevin MacLeod (https://incompetech.com) Licence: CC BY (http://creativecommons.org/licenses/by/4.0/)

Glom, Sears, The Crafts, Finding your why is crucial, losing it is devasting. Look what I found?

Elizabethan Collar, this is esophagus, Angel Olson, Raglani, Red On, Muscles, Expo 70, Los Condenados, Japanese Treats, M Geddes Gengras, Ray Phaze Tropic, Karl Fousek, Glom, Due Molly, and Andy Loebs.

Elizabethan Collar, this is esophagus, Angel Olson, Raglani, Red On, Muscles, Expo 70, Los Condenados, Japanese Treats, M Geddes Gengras, Ray Phaze Tropic, Karl Fousek, Glom, Due Molly, and Andy Loebs.