Podcasts about uk dementia research institute

Dr Clíona Farrell, narrating her blog written for the Dementia Researcher website. In this blog, Clíona explores the challenge of facing an uncertain future as her first postdoc contract nears its end. Choosing to take a career break for travel without a fixed plan in place, she reflects on her discomfort with uncertainty, the pressure of well-meaning questions from others, and the wider instability faced by early career researchers. While offering no tidy solutions, Clíona shares what's helping her cope, and invites others to join the conversation about managing change and the unknown. Find the original text, and narration here on our website. https://www.dementiaresearcher.nihr.ac.uk/blog-how-to-be-okay-facing-the-unknown/ -- Dr Clíona Farrell is a Postdoctoral Researcher in the UK Dementia Research Institute at University College London. Her work focuses on understanding neuroinflammation in Down syndrome, both prior to, and in response to, Alzheimer's disease pathology. Originally from Dublin, Ireland, Clíona completed her undergraduate degree in Neuroscience in Trinity College, and then worked as a research assistant in the Royal College of Surgeons studying ALS and Parkinson's disease. She also knows the secret behind scopping the perfect 99 ice-cream cone. @ClionaFarrell_ -- Enjoy listening? We're always looking for new bloggers, drop us a line. http://www.dementiaresearcher.nihr.ac.uk This podcast is brought to you in association with Alzheimer's Association, Alzheimer's Research UK, Alzheimer's Society and Race Against Dementia, who we thank for their ongoing support. -- Follow us on Social Media: https://www.instagram.com/dementia_researcher/ https://www.facebook.com/Dementia.Researcher/ https://twitter.com/demrescommunity https://www.linkedin.com/company/dementia-researcher https://bsky.app/profile/dementiaresearcher.bsky.social

Dr Clíona Farrell, narrating her blog written for the Dementia Researcher website. In this blog, Clíona reflects on the step-by-step process of getting her first first-author data paper published. Drawing on a project that began during her PhD and continued into her postdoc, Clíona highlights the many layers of work involved – from early authorship discussions to final submission and revisions. Her account underscores how time-consuming, iterative, and unexpectedly complex academic publishing can be, offering an honest and practical perspective for researchers navigating their first manuscript journey. Find the original text, and narration here on our website. https://www.dementiaresearcher.nihr.ac.uk/blog-first-time-through-the-publication-process/ -- Dr Clíona Farrell is a Postdoctoral Researcher in the UK Dementia Research Institute at University College London. Her work focuses on understanding neuroinflammation in Down syndrome, both prior to, and in response to, Alzheimer's disease pathology. Originally from Dublin, Ireland, Clíona completed her undergraduate degree in Neuroscience in Trinity College, and then worked as a research assistant in the Royal College of Surgeons studying ALS and Parkinson's disease. She also knows the secret behind scopping the perfect 99 ice-cream cone. @ClionaFarrell_ -- Enjoy listening? We're always looking for new bloggers, drop us a line. http://www.dementiaresearcher.nihr.ac.uk This podcast is brought to you in association with Alzheimer's Association, Alzheimer's Research UK, Alzheimer's Society and Race Against Dementia, who we thank for their ongoing support. -- Follow us on Social Media: https://www.instagram.com/dementia_researcher/ https://www.facebook.com/Dementia.Researcher/ https://twitter.com/demrescommunity https://www.linkedin.com/company/dementia-researcher https://bsky.app/profile/dementiaresearcher.bsky.social

This year's AD/PD Conference was held in Vienna, Austria from the 1st to 5th April. In this first of a two-part special we bring you highlights from the first three days of the conference. The AD/PD Conference focuses on basic science and translational and clinical research bringing New insights on disease mechanisms and etiologies, the latest findings from clinical trials, innovative outlooks on therapy and prevention and advances in diagnostic markers. In this special on-location recording our guest host Dr Amanda Heslegrave, Principle Investigator and Co-Lead of fluid biomarker laboratory from the UK Dementia Research Institute at University College London talks with: Dr Loukia Katsouri, Senior Research Fellow at the UCL Gatsby Foundation. Loukia studies the molecular mechanisms of tau propagation in Alzheimer's disease. She aims to understand how the presence of tau is affecting the spread and the severity of the disease. Dr Anna Mallach, Research Fellow in the UK Dementia Research Institute at Imperial College London. Anna's work focusses on understanding the role of cellular interactions in contributing to neurodegenerative diseases. Dr Imogen Swift, Research Scientist at Vesper Bio. Imogen is a neuroscience specialist focusing on biomarker and preclinical development in neurodegenerative therapeutics spanning frontotemporal dementia, Alzheimer's Disease. Here are just a few highlights from the discussion:

Dr Clíona Farrell, narrating her blog written for the Dementia Researcher website. In this blog, Clíona reflects on her experience at the UK DRI Vascular ECR conference, where patient and public involvement and engagement (PPIE) was embedded throughout the event. From shaping research discussions to helping early career researchers improve accessibility, Clíona shares how the inclusion of lived experience experts made the conference more insightful, collaborative, and engaging. She argues that PPIE isn't just for clinical researchers – it benefits preclinical science too and should be a standard part of the research process. Find the original text, and narration here on our website. https://www.dementiaresearcher.nihr.ac.uk/blog-how-ppie-involvement-can-improve-a-conference/ -- Dr Clíona Farrell is a Postdoctoral Researcher in the UK Dementia Research Institute at University College London. Her work focuses on understanding neuroinflammation in Down syndrome, both prior to, and in response to, Alzheimer's disease pathology. Originally from Dublin, Ireland, Clíona completed her undergraduate degree in Neuroscience in Trinity College, and then worked as a research assistant in the Royal College of Surgeons studying ALS and Parkinson's disease. She also knows the secret behind scopping the perfect 99 ice-cream cone. @ClionaFarrell_ -- Enjoy listening? We're always looking for new bloggers, drop us a line. http://www.dementiaresearcher.nihr.ac.uk This podcast is brought to you in association with Alzheimer's Association, Alzheimer's Research UK, Alzheimer's Society and Race Against Dementia, who we thank for their ongoing support. -- Follow us on Social Media: https://www.instagram.com/dementia_researcher/ https://www.facebook.com/Dementia.Researcher/ https://twitter.com/demrescommunity https://www.linkedin.com/company/dementia-researcher https://bsky.app/profile/dementiaresearcher.bsky.social

Last week we were in Birmingham for this years Alzheimer's Research UK Conference. Hearing from researchers talking about their work and to learn about the latest discoveries in dementia research. In the show guest host and regular blogger Rebecca Williams talks with Dr Beth Williams, from the UK Dementia Research Institute at The University of Edinburgh, Gargi Roy from Bristol Medical School and Donatella Di Rienzo from the Alzheimer's Research UK Oxford Drug Discovery Institute. -- For more information on the event and the great work of Alzheimer's Research UK visit https://www.alzheimersresearchuk.org/research/for-researchers/research-conference Full biographies on all our guests and a transcript can be found on our website: https://www.dementiaresearcher.nihr.ac.uk -- Like what you hear? Please review, like, and share our podcast - and don't forget to subscribe to ensure you never miss an episode – and if you prefer to watch rather than listen, you'll find a video version of this podcast with full captions on our YouTube Channel: youtu.be/fuB4Y2KSt94 -- This podcast is brought to you by University College London / UCLH NIHR Biomedical Research Centre in association with Alzheimer's Association, Alzheimer's Research UK, Alzheimer's Society and Race Against Dementia who we thank for their ongoing support. -- Follow us on Social Media: www.instagram.com/dementia_researcher/ www.facebook.com/Dementia.Researcher/ twitter.com/demrescommunity www.bsky.app/profile/dementiare…archer.bsky.social www.linkedin.com/company/dementia-researcher

Dr Clíona Farrell, narrating her blog written for the Dementia Researcher website. Clíona shares her experience of peer reviewing a research paper for the first time, reflecting on the challenges, learning process, and confidence needed to take on this key academic role. From tackling imposter syndrome to using structured resources and thoughtful feedback, she offers valuable insights for early career researchers looking to step into peer review. Find the original text, and narration here on our website. https://www.dementiaresearcher.nihr.ac.uk/blog-my-first-time-as-a-peer-reviewer/ -- Dr Clíona Farrell is a Postdoctoral Researcher in the UK Dementia Research Institute at University College London. Her work focuses on understanding neuroinflammation in Down syndrome, both prior to, and in response to, Alzheimer's disease pathology. Originally from Dublin, Ireland, Clíona completed her undergraduate degree in Neuroscience in Trinity College, and then worked as a research assistant in the Royal College of Surgeons studying ALS and Parkinson's disease. She also knows the secret behind scopping the perfect 99 ice-cream cone. @ClionaFarrell_ -- Enjoy listening? We're always looking for new bloggers, drop us a line. http://www.dementiaresearcher.nihr.ac.uk This podcast is brought to you in association with Alzheimer's Association, Alzheimer's Research UK, Alzheimer's Society and Race Against Dementia, who we thank for their ongoing support. -- Follow us on Social Media: https://www.instagram.com/dementia_researcher/ https://www.facebook.com/Dementia.Researcher/ https://twitter.com/demrescommunity https://www.linkedin.com/company/dementia-researcher https://bsky.app/profile/dementiaresearcher.bsky.social

Episode Links: Write down your thoughts and shred them to relieve anger, researchers say How to Deal with Guilt: 14 Tips for Coping YOUR FEAR IS BORING. I can say this with all honesty and authority, because I k… Life doesn't happen to you, it happens for you How to Help Others Through a Difficult Transition Kaleidoscope Health and Care 9 Things to Do When Change Is Forced on You The Imposter Syndrome One The “in-between” times of transition are amazing opportunities for growth and reflection. Transition is an Opportunity for Growth The power of a slow transition Transition The Power Of Curiosity In The Workplace   Our first guests is Chrysa Vazitari. Chrysa is a silver award winner as the best EMEA coach. She is focusing on career advancement, career pivots and burnout prevention. She is a PCC-certified coach by ICF and she is using different methodologies in her coaching like LEGO Serious Play, phototherapy, embodiment to support the self-discovery and to keep her sessions and workshops fun and engaging.  https://www.linkedin.com/in/chrysanthi-vazitari/ website link:  https://www.chrysalogy.com/   Krystyna Mailer is an instructional and graphic design specialist with expertise in visual communication, e-learning course development, video creation and job aid design. Known for her ability to transform complex information into clear and engaging learning materials, her mission is to create solutions that are both impactful and practical. She has an instagram and a TikTok page sharing tools, tips and practices on instructional design @learningdesigntime and a portfolio website www.krystynamailer.com https://www.linkedin.com/in/krystyna-mailer/   Juliet Morris is a multi-award-winning leader and coach dedicated to helping people create purpose-driven, sustainable futures. With expertise in leadership, sensemaking, and coaching (Clean Language, executive coaching, and mental fitness), she partners with those seeking meaningful progress. Currently, Juliet is Chief People & Culture Officer at the UK Dementia Research Institute.   In her spare time, Juliet writes a weekly newsletter, "I.F. Club," hosts thought-provoking podcasts, volunteers at school career events, and serves as a delegate for UN Women UK. She's also training in five-element acupuncture. LinkedIn: Juliet Morris Subscribe: I.F. Club Listen: What Kind of Future?   You can contact Women Talking About Learning through our website, womentalkingaboutlearning.com We're on Twitter @WTAL_Podcast You can buy us a coffee to support Women Talking About Learning via Ko-Fi. Or you can email us via hello@llarn.com

Dr Clíona Farrell, narrating her blog written for the Dementia Researcher website. Clíona shares her experience of a collaborative research visit to a US lab, detailing the planning process, securing funding, and navigating visa requirements. She highlights the benefits of international collaborations, from accessing rare samples to gaining new research perspectives. Clíona provides practical advice on networking, early planning, and making the most of the visit, including shadowing new techniques and engaging with other researchers. Reflecting on her time in California, she emphasises the professional and personal growth gained from the experience and encourages others to explore similar opportunities. Find the original text, and narration here on our website. https://www.dementiaresearcher.nihr.ac.uk/blog-experience-from-a-collaborative-research-trip/ -- Dr Clíona Farrell is a Postdoctoral Researcher in the UK Dementia Research Institute at University College London. Her work focuses on understanding neuroinflammation in Down syndrome, both prior to, and in response to, Alzheimer's disease pathology. Originally from Dublin, Ireland, Clíona completed her undergraduate degree in Neuroscience in Trinity College, and then worked as a research assistant in the Royal College of Surgeons studying ALS and Parkinson's disease. She also knows the secret behind scopping the perfect 99 ice-cream cone. @ClionaFarrell_ -- Enjoy listening? We're always looking for new bloggers, drop us a line. http://www.dementiaresearcher.nihr.ac.uk This podcast is brought to you in association with Alzheimer's Association, Alzheimer's Research UK, Alzheimer's Society and Race Against Dementia, who we thank for their ongoing support. -- Follow us on Social Media: https://www.instagram.com/dementia_researcher/ https://www.facebook.com/Dementia.Researcher/ https://twitter.com/demrescommunity https://www.linkedin.com/company/dementia-researcher https://bsky.app/profile/dementiaresearcher.bsky.social

Greg and Matias interview Dr. Nir Grossman, one of the world's leading researchers in neurotechnology. Nir is a lecturer in the Department of Brain Sciences at Imperial College London and a founding fellow of the UK Dementia Research Institute. In this episode, we discuss:What is temporal interference (TI), a non-invasive stimulation methodA comparison of TI with deep brain stimulation (DBS)How physics plays a crucial role in neuroscience innovationTranslating TI academic research to clinical useTI's role in treating Alzheimer's, epilepsy, depression, and traumatic brain injuryCredits:Created by Greg Kubin and Matias SerebrinskyHost: Matias Serebrinsky & Greg KubinProduced by Jonathan A. Davis,  Nico V. Rey & Caitlin NerFind us at businesstrip.fm and psymed.venturesFollow us on Instagram and Twitter!Theme music by Dorian LoveAdditional Music: Distant Daze by Zack Frank

Dr Clíona Farrell, narrating her blog written for the Dementia Researcher website. Explore the lesser-known yet vital aspect of Alzheimer's disease in our latest blog from Clíona. This post gets into the complex world of amyloid-β deposition within the brain's blood vessels. Clíona is embarking on a new postdoc project focused on this area, and in this article she shares insights into how Cerebral Amyloid Angiopathy (CAA) not only coexists with Alzheimer's but also significantly impacts disease pathology and patient outcomes. Discover the implications of recent anti-amyloid therapies and why understanding CAA is crucial for future Alzheimer's treatments. Find the original text, and narration here on our website. https://www.dementiaresearcher.nihr.ac.uk/blog-a-vascular-element-of-alzheimers-cerebral-amyloid-angiopathy/ -- Dr Clíona Farrell is a Postdoctoral Researcher in the UK Dementia Research Institute at University College London. Her work focuses on understanding neuroinflammation in Down syndrome, both prior to, and in response to, Alzheimer's disease pathology. Originally from Dublin, Ireland, Clíona completed her undergraduate degree in Neuroscience in Trinity College, and then worked as a research assistant in the Royal College of Surgeons studying ALS and Parkinson's disease. She also knows the secret behind scopping the perfect 99 ice-cream cone. @ClionaFarrell_ -- Enjoy listening? We're always looking for new bloggers, drop us a line. http://www.dementiaresearcher.nihr.ac.uk This podcast is brought to you in association with Alzheimer's Association, Alzheimer's Research UK, Alzheimer's Society and Race Against Dementia, who we thank for their ongoing support. -- Follow us on Social Media: https://www.instagram.com/dementia_researcher/ https://www.facebook.com/Dementia.Researcher/ https://twitter.com/demrescommunity https://www.linkedin.com/company/dementia-researcher https://bsky.app/profile/dementiaresearcher.bsky.social

Dr Clíona Farrell, narrating her blog written for the Dementia Researcher website. Clíona discusses her decision to transition from PhD student to postdoc in the same lab, weighing the benefits and potential drawbacks. She reflects on the comfort of familiar surroundings and established relationships, which helped her dive straight into new projects and finalise her PhD work. Yet, this continuity also brings unique challenges, from overlapping responsibilities to the risk of limited career progression if not carefully navigated. Clíona's insights offer a nuanced look at whether staying put can be the right path for early-career researchers. Find the original text, and narration here on our website. https://www.dementiaresearcher.nihr.ac.uk/blog-should-you-stay-pros-and-cons-of-postdocing-in-your-phd-lab/ #PhDPosition #PhDLife #PhDFunding #PhDApplications -- Dr Clíona Farrell is a Postdoctoral Researcher in the UK Dementia Research Institute at University College London. Her work focuses on understanding neuroinflammation in Down syndrome, both prior to, and in response to, Alzheimer's disease pathology. Originally from Dublin, Ireland, Clíona completed her undergraduate degree in Neuroscience in Trinity College, and then worked as a research assistant in the Royal College of Surgeons studying ALS and Parkinson's disease. She also knows the secret behind scopping the perfect 99 ice-cream cone. @ClionaFarrell_ -- Enjoy listening? We're always looking for new bloggers, drop us a line. http://www.dementiaresearcher.nihr.ac.uk This podcast is brought to you in association with Alzheimer's Association, Alzheimer's Research UK, Alzheimer's Society and Race Against Dementia, who we thank for their ongoing support. -- Follow us on Social Media: https://www.instagram.com/dementia_researcher/ https://www.facebook.com/Dementia.Researcher/ https://twitter.com/demrescommunity https://www.linkedin.com/company/dementia-researcher https://bsky.app/profile/dementiaresearcher.bsky.social

Dr Clíona Farrell, narrating her blog written for the Dementia Researcher website. Clíona shares a typical week looks like for a PhD student. From lab work and data analysis to committee meetings and outreach events, Clíona shares her experiences from each year of her PhD, offering valuable insights into the challenges and rewards of life as a researcher. Whether you're considering a PhD or just curious about the process, this blog provides an honest look at the variety and commitment involved in pursuing a research career. Find the original text, and narration here on our website. https://www.dementiaresearcher.nihr.ac.uk/blog-journey-to-a-phd-a-week-in-the-life-of-a-phd-student/ #PhDPosition #PhDLife #PhDFunding #PhDApplications -- Dr Clíona Farrell is a Postdoctoral Researcher in the UK Dementia Research Institute at University College London. Her work focuses on understanding neuroinflammation in Down syndrome, both prior to, and in response to, Alzheimer's disease pathology. Originally from Dublin, Ireland, Clíona completed her undergraduate degree in Neuroscience in Trinity College, and then worked as a research assistant in the Royal College of Surgeons studying ALS and Parkinson's disease. She also knows the secret behind scopping the perfect 99 ice-cream cone. @ClionaFarrell_ -- Enjoy listening? We're always looking for new bloggers, drop us a line. http://www.dementiaresearcher.nihr.ac.uk This podcast is brought to you in association with Alzheimer's Association, Alzheimer's Research UK, Alzheimer's Society and Race Against Dementia, who we thank for their ongoing support. -- Follow us on Social Media: https://www.instagram.com/dementia_researcher/ https://www.facebook.com/Dementia.Researcher/ https://twitter.com/demrescommunity https://www.linkedin.com/company/dementia-researcher https://bsky.app/profile/dementiaresearcher.bsky.social

Dr Clíona Farrell, narrating her blog written for the Dementia Researcher website. In the second of her three-part series Clíona offers practical advice for those applying to PhD programmes. She begins by discussing the importance of tailoring applications to specific projects and carefully reading job descriptions to meet both essential and desirable criteria. Clíona outlines the key components of a standout application: a clear, concise CV that highlights relevant education, research experience, and skills, and a personalised cover letter that demonstrates enthusiasm for the project and lab.   She recommends structuring the cover letter into two parts: the first part focuses on how the applicant's skills and experience make them suitable for the position, using evidence-based examples, while the second part explains why they are interested in the specific lab and project. Dr Farrell emphasises the importance of proofreading and personalising each application to improve chances of success. Remember... not to be discouraged by missing one or two skills and apply confidently. Find the original text, and narration here on our website. https://www.dementiaresearcher.nihr.ac.uk/blog-how-to-write-a-standout-cv-and-cover-letter/ #PhDPosition #PhDLife #PhDFunding #PhDApplications -- Dr Clíona Farrell is a Postdoctoral Researcher in the UK Dementia Research Institute at University College London. Her work focuses on understanding neuroinflammation in Down syndrome, both prior to, and in response to, Alzheimer's disease pathology. Originally from Dublin, Ireland, Clíona completed her undergraduate degree in Neuroscience in Trinity College, and then worked as a research assistant in the Royal College of Surgeons studying ALS and Parkinson's disease. She also knows the secret behind scopping the perfect 99 ice-cream cone. @ClionaFarrell_ -- Enjoy listening? We're always looking for new bloggers, drop us a line. http://www.dementiaresearcher.nihr.ac.uk This podcast is brought to you in association with Alzheimer's Association, Alzheimer's Research UK, Alzheimer's Society and Race Against Dementia, who we thank for their ongoing support. -- Follow us on Social Media: https://www.instagram.com/dementia_researcher/ https://www.facebook.com/Dementia.Researcher/ https://twitter.com/demrescommunity https://www.linkedin.com/company/dementia-researcher https://bsky.app/profile/dementiaresearcher.bsky.social

Dr Clíona Farrell, narrating her blog written for the Dementia Researcher website. In the first of her three-part series Clíona shares her personal journey to obtaining a PhD, offering insights into the challenges and decisions she faced along the way. From her undergraduate experience at Trinity College Dublin to working as a research assistant in Ireland, Clíona reflects on how she navigated the uncertainty of whether a PhD was the right path for her. She emphasises the importance of gaining lab experience, working in diverse teams, and seeking mentorship. Clíona also discusses the application process, the role of advertised PhD positions, and encourages aspiring researchers to be proactive in reaching out to potential supervisors. Her story highlights that there are many routes to a PhD and offers practical advice for those considering this path. Find the original text, and narration here on our website. https://www.dementiaresearcher.nihr.ac.uk/blog-journey-to-a-phd-how-to-get-there/ #PhDPosition #PhDLife #PhDFunding #PhDApplications -- Dr Clíona Farrell is a Postdoctoral Researcher in the UK Dementia Research Institute at University College London. Her work focuses on understanding neuroinflammation in Down syndrome, both prior to, and in response to, Alzheimer's disease pathology. Originally from Dublin, Ireland, Clíona completed her undergraduate degree in Neuroscience in Trinity College, and then worked as a research assistant in the Royal College of Surgeons studying ALS and Parkinson's disease. She also knows the secret behind scopping the perfect 99 ice-cream cone. @ClionaFarrell_ -- Enjoy listening? We're always looking for new bloggers, drop us a line. http://www.dementiaresearcher.nihr.ac.uk This podcast is brought to you in association with Alzheimer's Association, Alzheimer's Research UK, Alzheimer's Society and Race Against Dementia, who we thank for their ongoing support. -- Follow us on Social Media: https://www.instagram.com/dementia_researcher/ https://www.facebook.com/Dementia.Researcher/ https://twitter.com/demrescommunity https://www.linkedin.com/company/dementia-researcher https://bsky.app/profile/dementiaresearcher.bsky.social

Dr Clíona Farrell, narrating her blog written for the Dementia Researcher website. Clíona discusses the importance of understanding your audience in effective science communication. She emphasises that communicating scientific research requires tailoring the content and presentation style to different audiences, whether they are laypeople, students, or individuals with specific needs. Through various examples from her experiences, she highlights the importance of engaging the audience by relating scientific findings to broader, more relatable contexts and ensuring accessibility in both language and format. This blog underscores the significance of being well-prepared, respectful, and aware of current developments in the field to facilitate meaningful engagement and avoid alienating the audience. Find the original text, and narration here on our website. https://www.dementiaresearcher.nihr.ac.uk/blog-communicating-your-science-effectively-know-your-audience/ #DementiaResearch #DownSyndrome #ScienceCommunications -- Dr Clíona Farrell is a Postdoctoral Researcher in the UK Dementia Research Institute at University College London. Her work focuses on understanding neuroinflammation in Down syndrome, both prior to, and in response to, Alzheimer's disease pathology. Originally from Dublin, Ireland, Clíona completed her undergraduate degree in Neuroscience in Trinity College, and then worked as a research assistant in the Royal College of Surgeons studying ALS and Parkinson's disease. She also knows the secret behind scopping the perfect 99 ice-cream cone. @ClionaFarrell_ -- Enjoy listening? We're always looking for new bloggers, drop us a line. http://www.dementiaresearcher.nihr.ac.uk This podcast is brought to you in association with Alzheimer's Association, Alzheimer's Research UK, Alzheimer's Society and Race Against Dementia, who we thank for their ongoing support. -- Follow us on Social Media: https://www.instagram.com/dementia_researcher/ https://www.facebook.com/Dementia.Researcher/ https://twitter.com/demrescommunity https://www.linkedin.com/company/dementia-researcher https://bsky.app/profile/dementiaresearcher.bsky.social

Dr Clíona Farrell, narrating her blog written for the Dementia Researcher website. Clíona she shares highlights from the 2024 International Trisomy 21 Research Society (T21RS) conference in Rome. Focusing on Alzheimer's disease in individuals with Down syndrome, Clíona discusses the latest research advancements, the genetic link between Down syndrome and Alzheimer's, and the critical need for inclusive clinical trials. The blog also emphasises the conference's commitment to accessibility and inclusivity, featuring engaging sessions for researchers, individuals with Down syndrome, and their families.    Find the original text, and narration here on our website. https://www.dementiaresearcher.nihr.ac.uk/blog-news-from-the-trisomy-21-research-society-conference/ #DementiaResearch #DownSyndrome #Trisomy21 -- Dr Clíona Farrell is a Postdoctoral Researcher in the UK Dementia Research Institute at University College London. Her work focuses on understanding neuroinflammation in Down syndrome, both prior to, and in response to, Alzheimer's disease pathology. Originally from Dublin, Ireland, Clíona completed her undergraduate degree in Neuroscience in Trinity College, and then worked as a research assistant in the Royal College of Surgeons studying ALS and Parkinson's disease. She also knows the secret behind scopping the perfect 99 ice-cream cone. @ClionaFarrell_   -- Enjoy listening? We're always looking for new bloggers, drop us a line. http://www.dementiaresearcher.nihr.ac.uk This podcast is brought to you in association with Alzheimer's Association, Alzheimer's Research UK, Alzheimer's Society and Race Against Dementia, who we thank for their ongoing support. -- Follow us on Social Media: https://www.instagram.com/dementia_researcher/ https://www.facebook.com/Dementia.Researcher/ https://twitter.com/demrescommunity https://www.linkedin.com/company/dementia-researcher

Dr Clíona Farrell, narrating her blog written for the Dementia Researcher website. Clíona shares her personal journey of writing a PhD thesis, offering invaluable tips and strategies to make the process more manageable and enjoyable. She emphasises the importance of meticulous planning, from setting clear timelines and choosing examiners to structuring the thesis and selecting conducive writing environments. Cliona candidly discusses the challenges she faced (but you will notice she is Dr, so it worked), including managing time effectively and maintaining a work-life balance, while encouraging readers to celebrate small milestones and prioritize self-care. Her practical advice aims to demystify the thesis-writing process, making it less daunting for PhD students.   Find the original text, and narration here on our website. https://www.dementiaresearcher.nihr.ac.uk/blog-tackling-the-phd-thesis-through-planning/ #DementiaResearch #ThesisWriting #PhDStudent #PhDTips #PhDHelp -- Dr Clíona Farrell is a Postdoctoral Researcher in the UK Dementia Research Institute at University College London. Her work focuses on understanding neuroinflammation in Down syndrome, both prior to, and in response to, Alzheimer's disease pathology. Originally from Dublin, Ireland, Clíona completed her undergraduate degree in Neuroscience in Trinity College, and then worked as a research assistant in the Royal College of Surgeons studying ALS and Parkinson's disease. She also knows the secret behind scopping the perfect 99 ice-cream cone. @ClionaFarrell_   -- Enjoy listening? We're always looking for new bloggers, drop us a line. http://www.dementiaresearcher.nihr.ac.uk This podcast is brought to you in association with Alzheimer's Association, Alzheimer's Research UK, Alzheimer's Society and Race Against Dementia, who we thank for their ongoing support. -- Follow us on Social Media: https://www.instagram.com/dementia_researcher/ https://www.facebook.com/Dementia.Researcher/ https://twitter.com/demrescommunity https://www.linkedin.com/company/dementia-researcher

Dr Gaia Brezzo narrates her blog written for Dementia Researcher. Drawing on a study published in Current Sociology, Gaia explores how societal gender roles have seeped into academia, leading to women disproportionately shouldering 'academic housework'—non-meritorious tasks like mentoring students and organizing conferences. The study, involving 163 interviews with social science professors in Denmark, categorises responses to academic admin into compliance, evasiveness, barter, and investment, revealing stark gender differences in engagement. Women, more often than not, find themselves in positions of compliance, accepting and performing these tasks far more than their male counterparts who frequently evade them. The implications are significant, affecting women's research output and career progression within academia. To gain a deeper understanding of this pervasive issue and its potential solutions, read the full blog or listen to Dr. Brezzo's narration for more insights. Find the original text, and narration here on our website. https://www.dementiaresearcher.nihr.ac.uk/blog-who-does-the-housework-in-academia/ #DementiaResearch #AcademicHousework #Academia #ResearchCulture -- Dr Gaia Brezzo is a Research Fellow based within the UK Dementia Research Institute at The University of Edinburgh. Gaia's research focuses on understanding how immune alterations triggered by stroke shape chronic maladaptive neuroimmune responses that lead to post-stroke cognitive decline and vascular dementia. Raised in Italy, Gaia came to the UK to complete her undergraduate degree, and thankfully, stuck around. Gaia writes about her work and career challenges, when not biking her way up and down hills in Edinburgh. Follow Gaia on Twitter: @Gaia_Brezzo -- Enjoy listening? We're always looking for new bloggers, drop us a line. http://www.dementiaresearcher.nihr.ac.uk This podcast is brought to you in association with Alzheimer's Association, Alzheimer's Research UK, Alzheimer's Society and Race Against Dementia, who we thank for their ongoing support. -- Follow us on Social Media: https://www.instagram.com/dementia_researcher/ https://www.facebook.com/Dementia.Researcher/ https://twitter.com/demrescommunity https://www.linkedin.com/company/dementia-researcher

In this episode of the Epigenetics Podcast, we talked with Sarah Marzi from the UK Dementia Research Institute at Imperial College London about her work on epigenetic changes in Alzheimer's Disease, and comparing CUT&Tag to ENCODE ChIP-Seq using limited cell samples. The interview discusses Sarah Marzi's work on ChIP-Seq experiments and their significance in understanding Alzheimer's disease from an epigenetic perspective. The discussion touches on the widespread dysregulation and changes in acetylation, particularly in genes associated with Alzheimer's risk, providing insights into potential links between epigenetic insults and disease onset. Moving on to the technical aspects of the study, the interview examines the strategic use of CUT&Tag. It explores the challenges and optimizations involved in accurately profiling limited cell samples. The dialogue also compares CUT&Tag to ENCODE ChIP-Seq, highlighting the complexities of peak calling and data interpretation across different methodologies.   References Kumsta, R., Marzi, S., Viana, J. et al. Severe psychosocial deprivation in early childhood is associated with increased DNA methylation across a region spanning the transcription start site of CYP2E1. Transl Psychiatry 6, e830 (2016). https://doi.org/10.1038/tp.2016.95 Marzi, S. J., Schilder, B. M., Nott, A., Frigerio, C. S., Willaime‐Morawek, S., Bucholc, M., Hanger, D. P., James, C., Lewis, P. A., Lourida, I., Noble, W., Rodriguez‐Algarra, F., Sharif, J., Tsalenchuk, M., Winchester, L. M., Yaman, Ü., Yao, Z., The Deep Dementia Phenotyping (DEMON) Network, Ranson, J. M., & Llewellyn, D. J. (2023). Artificial intelligence for neurodegenerative experimental models. Alzheimer's & Dementia, 19(12), 5970–5987. https://doi.org/10.1002/alz.13479 Marzi, S. J., Leung, S. K., Ribarska, T., Hannon, E., Smith, A. R., Pishva, E., Poschmann, J., Moore, K., Troakes, C., Al-Sarraj, S., Beck, S., Newman, S., Lunnon, K., Schalkwyk, L. C., & Mill, J. (2018). A histone acetylome-wide association study of Alzheimer's disease identifies disease-associated H3K27ac differences in the entorhinal cortex. Nature Neuroscience, 21(11), 1618–1627. https://doi.org/10.1038/s41593-018-0253-7 Hu, D., Abbasova, L., Schilder, B. M., Nott, A., Skene, N. G., & Marzi, S. J. (2022). CUT&Tag recovers up to half of ENCODE ChIP-seq peaks in modifications of H3K27 [Preprint]. Genomics. https://doi.org/10.1101/2022.03.30.486382   Related Episodes When is a Peak a Peak? (Claudio Cantù) Development of Integrative Machine Learning Tools for Neurodegenerative Diseases (Enrico Glaab) DNA Methylation Alterations in Neurodegenerative Diseases (Paula Desplats)   Contact Epigenetics Podcast on X Epigenetics Podcast on Instagram Epigenetics Podcast on Mastodon Epigenetics Podcast on Bluesky Epigenetics Podcast on Threads Active Motif on X Active Motif on LinkedIn Email: podcast@activemotif.com

Dr Kathryn Bowles explains her fascinating research into a little known gene that is thought to help protect the brain. It is hoped that discovering how this process works will provide vital new knowledge as to why some people develop Parkinson's and others don't. Kat also talks Julie and Helga through the complex world of genetic research, how it has developed over recent years, and why it can take so long to see progress.     www.bowleslab.co.uk   https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9284779/pdf/13024_2022_Article_551.pdf

Thanks to Sannia Farrukh and the ICGEB for their support in making this show!It's thought that by the end of the decade, 78 million people around the world will have Alzheimer's disease. It's debilitating and progressive. It robs people of their personality, their independence, and their quality of life. And caring for people with the condition, which often goes on over many years, is extremely costly, both financially and emotionally. The biggest risk factor is age; and as the proportion of the population living into their 80s, when as many as a fifth of individuals can develop the condition,... Like this podcast? Please help us by supporting the Naked Scientists

This year's AD/PD Conference was held in Lisbon, Portugal from the 5th to 9th March. In this second of a two-part special we bring you highlights from the last few days of the conference. The AD/PD Conference focuses on basic science and translational and clinical research bringing New insights on disease mechanisms and etiologies, the latest findings from clinical trials, innovative outlooks on therapy and prevention and advances in diagnostic markers. In this special on-location recording our guest host Dr Emily Maguire, Senior Research Associate from the UK Dementia Research Institute at Cardiff University talks with: Dr Daniel Erskine, Senior Lecturer at Newcastle University. Dr Heather Snyder, Alzheimer's Association Vice President, Medical & Scientific Relations & Dr Timothy Siegert, Co-Founder, President & COO of Allyx Therapeutics. -- For more information on the event visit: https://adpd.kenes.com/ Full biographies on all our guests and a transcript can be found on our website: https://www.dementiaresearcher.nihr.ac.uk -- Like what you hear? Please review, like, and share our podcast - and don't forget to subscribe to ensure you never miss an episode – and if you prefer to watch rather than listen, you'll find a video version of this podcast on our YouTube Channel https://youtu.be/154FZrzwLwE This podcast is brought to you by University College London / UCLH NIHR Biomedical Research Centre in association with Alzheimer's Association, Alzheimer's Research UK, Alzheimer's Society and Race Against Dementia who we thank for their ongoing support. -- Follow us on Social Media: http://www.instagram.com/dementia_researcher/ http://www.facebook.com/Dementia.Researcher/ http://twitter.com/demrescommunity http://bsky.app/profile/dementiaresearcher.bsky.social http://www.linkedin.com/company/dementia-researcher #dementiaresearch #adpd2024 #ADPDConference

This year's AD/PD Conference was held in Lisbon, Portugal from the 5th to 9th March. In this first of a two-part special we bring you highlights from the first three days of the conference. The AD/PD Conference focuses on basic science and translational and clinical research bringing New insights on disease mechanisms and etiologies, the latest findings from clinical trials, innovative outlooks on therapy and prevention and advances in diagnostic markers. In this special on-location recording our guest host Dr Amanda Heslegrave, Senior Research Associate and Co-Lead of fluid biomarker laboratory from the UK Dementia Research Institute at University College London talks with: Dr Ian Harrison, Senior Research Fellow at University College London studying the role of clearance systems in the brain, and their involvement in the development and treatment of neurodegenerative diseases. Dr Ariana Gatt, Senior Research Fellow at University College London investigating the role of RNA-binding proteins in neurodegenerative disease with a focus on Frontotemporal dementia. Jess Tobin, Science Communications Manager at Alzheimer's Research UK. -- For more information on the event visit: adpd.kenes.com/ Full biographies on all our guests and a transcript can be found on our website: https://www.dementiaresearcher.nihr.ac.uk -- Like what you hear? Please review, like, and share our podcast - and don't forget to subscribe to ensure you never miss an episode – and if you prefer to watch rather than listen, you'll find a video version of this podcast on our YouTube Channel youtu.be/UQdm8aWuoFM This podcast is brought to you by University College London / UCLH NIHR Biomedical Research Centre in association with Alzheimer's Association, Alzheimer's Research UK, Alzheimer's Society and Race Against Dementia who we thank for their ongoing support. -- Follow us on Social Media: http://www.instagram.com/dementia_researcher/ http://www.facebook.com/Dementia.Researcher/ http://twitter.com/demrescommunity http://bsky.app/profile/dementiaresearcher.bsky.social http://www.linkedin.com/company/dementia-researcher #dementiaresearch #adpd2024 #ADPDConference

Dr Gaia Brezzo narrates her blog written for Dementia Researcher. Gaia examines the (arguably) widespread issue of academic fraud, from the shock of discovering misconduct in familiar research to the systemic pressures that contribute to such deceit. She addresses the severe implications for public health and scientific integrity, while also discussing the need for better quality control and accountability within the scientific community. The blog advocates for a change in academic incentives and proposes utilising AI as a tool for detecting fraud, urging for a culture that protects rather than penalises whistleblowers. Find the original text, and narration here on our website. https://www.dementiaresearcher.nihr.ac.uk/blog-the-price-of-deception-academias-dark-side/ #DementiaResearch #AcademicMisconduct #Academia -- Dr Gaia Brezzo is a Research Fellow based within the UK Dementia Research Institute at The University of Edinburgh. Gaia's research focuses on understanding how immune alterations triggered by stroke shape chronic maladaptive neuroimmune responses that lead to post-stroke cognitive decline and vascular dementia. Raised in Italy, Gaia came to the UK to complete her undergraduate degree, and thankfully, stuck around. Gaia writes about her work and career challenges, when not biking her way up and down hills in Edinburgh. Follow Gaia on Twitter: @Gaia_Brezzo -- Enjoy listening? We're always looking for new bloggers, drop us a line. http://www.dementiaresearcher.nihr.ac.uk This podcast is brought to you in association with Alzheimer's Association, Alzheimer's Research UK, Alzheimer's Society and Race Against Dementia, who we thank for their ongoing support. -- Follow us on Social Media: https://www.instagram.com/dementia_researcher/ https://www.facebook.com/Dementia.Researcher/ https://twitter.com/demrescommunity https://bsky.app/profile/dementiaresearcher.bsky.social https://www.linkedin.com/company/dementia-researcher

Dr Adrien Rapeaux, Research Associate at Imperial College London (UK) Neural Engineering Lead at Mintneuro (Imperial College Spinout – Mintneuro designs chips for implantable neural interfaces) Researcher at the UK Dementia Research Institute, Care Research & Technology Centre With guest host Rob Breakenridge Learn more about your ad choices. Visit megaphone.fm/adchoices

Join PhD Student and Guest Host Rebecca Williams as she explores the often intricate and crucial world of research ethics approvals and participant consent in dementia research. Rebecca is joined by experts: Dr. Anna Volkmer, a Senior Research Fellow at University College London, Dr. Victoria Shepherd, Senior Fellow from Cardiff University, and Danielle Wilson, Head of Commercialisation and Ethics Chair from the UK Dementia Research Institute at Imperial College London. Our panelists bring a wealth of experience from various backgrounds, including speech and language therapy, nursing, research delivery, capacity evaluation, consent and health research ethics. They offer invaluable insights into the ethical, legal, and practical challenges of involving people with dementia and other conditions in research. The discussion covers a range of topics including the basics of research ethics, how to apply and manage participant consent, with tips for new applicants and goes further to explore the evolving landscape of research ethics in the age of emerging technologies like AI. This episode is a must-listen for anyone researchers involved in health and social care. Whether you're a seasoned researcher or new to the field, and making your first ethics application this show offers a unique opportunity to hear from experts who have led ethics panels and navigated these challenges themselves. -- Resources discussed in the show: HRA - Research Ethics Service and Research Ethics Committees https://bit.ly/3SnhNm8 HRA - What approvals and decisions do I need? https://bit.ly/3u6MtyF NIHR INCLUDE Impaired Capacity to Consent Framework https://bit.ly/3vJ39Nq -- Full biographies on all our guests and a transcript can be found on our website https://www.dementiaresearcher.nihr.ac.uk -- Like what you hear? Please review, like, and share our podcast - and don't forget to subscribe to ensure you never miss an episode – and if you prefer to watch rather than listen, you'll find a video version of this podcast on our website and YouTube Channel, with closed captions. https://youtu.be/lpcLXaBxpTE -- This podcast is brought to you in association with Alzheimer's Association, Alzheimer's Research UK, Alzheimer's Society and Race Against Dementia, who we thank for their ongoing support. -- Follow us on Social Media: https://www.instagram.com/dementia_researcher/ https://www.facebook.com/Dementia.Researcher/ https://twitter.com/demrescommunity https://bsky.app/profile/dementiaresearcher.bsky.social https://www.linkedin.com/company/dementia-researcher

Dr Gaia Brezzo narrates her blog written for Dementia Researcher. Whether you're a seasoned educator or about to deliver your first lecture, this blog offers invaluable tips and personal experiences to enhance your teaching approach. Gaia goes into the intricacies of making lectures engaging, avoiding common pitfalls, and utilising effective teaching aids. From planning and content arrangement to incorporating visual aids and handling unexpected challenges, this blog is a treasure trove of practical advice. Discover the secrets to captivating your audience, ensuring your material resonates, and transforming your lecture into an enriching experience for both you and your students. Don't miss out on this essential read for educators eager to refine their skills and inspire their students! Find the original text, and narration here on our website. https://www.dementiaresearcher.nihr.ac.uk/blog-unlocking-the-lecturing-toolkit-preparing-your-first-lecture/ -- Dr Gaia Brezzo is a Research Fellow based within the UK Dementia Research Institute at The University of Edinburgh. Gaia's research focuses on understanding how immune alterations triggered by stroke shape chronic maladaptive neuroimmune responses that lead to post-stroke cognitive decline and vascular dementia. Raised in Italy, Gaia came to the UK to complete her undergraduate degree, and thankfully, stuck around. Gaia writes about her work and career challenges, when not biking her way up and down hills in Edinburgh. Follow Gaia on Twitter: @Gaia_Brezzo -- Enjoy listening? We're always looking for new bloggers, drop us a line. http://www.dementiaresearcher.nihr.ac.uk This podcast is brought to you in association with Alzheimer's Association, Alzheimer's Research UK, Alzheimer's Society and Race Against Dementia, who we thank for their ongoing support. -- Follow us on Social Media: https://www.instagram.com/dementia_researcher/ https://www.facebook.com/Dementia.Researcher/ https://twitter.com/demrescommunity https://bsky.app/profile/dementiaresearcher.bsky.social https://www.linkedin.com/company/dementia-researcher

Dr Fiona McLean, ARUK Research Fellow, University of Dundee is joined by fellow experts Dr Kate Harris and Dr Sophie Morse, to explore the intricacies of the blood-brain barrier and its pivotal role in dementia research. They discuss pioneering methods in overcoming the barrier for drug delivery, the significance of endothelial cells in barrier integrity, and novel approaches in treating neurodegenerative diseases. The conversation also touches on the collaborative nature of neuroscience, offering invaluable insights for newcomers to the field. Don't miss this deep dive into the forefront of dementia research. -- Meet the guests: Dr Sophie Morse is a Research Fellow & UK DRI Emerging Leader at Imperial College London, within the UK Dementia Research Institute. Sophie is a biomedical engineer who leads a research group exploring the use of Therapeutic Ultrasound for Brain Diseases. Dr Kate Harris is an Academic Track Alzheimer's Research UK Fellow in Drug Discovery at Newcastle University. Kate is working on finding new drug targets for neurodegenerative disease in neuroinflammation. -- Links mentioned in the show: Rapid short-pulses of focused ultrasound and microbubbles deliver a range of agent sizes to the brain - https://bit.ly/41PFvuh -- Full biographies on all our guests and a transcript can be found on our website https://www.dementiaresearcher.nihr.ac.uk -- Like what you hear? Please review, like, and share our podcast - and don't forget to subscribe to ensure you never miss an episode – and if you prefer to watch rather than listen, you'll find a video version of this podcast on our website and YouTube Channel, with closed captions. https://youtu.be/1x_6ij9N6pU -- This podcast is brought to you in association with Alzheimer's Association, Alzheimer's Research UK, Alzheimer's Society and Race Against Dementia, who we thank for their ongoing support. -- Follow us on Social Media: https://www.instagram.com/dementia_researcher/ https://www.facebook.com/Dementia.Researcher/ https://twitter.com/demrescommunity https://bsky.app/profile/dementiaresearcher.bsky.social https://www.linkedin.com/company/dementia-researcher

Dr Gaia Brezzo narrates her blog written for Dementia Researcher. Gaia's blog, serves as a comprehensive guide to Fluorescence Activated Cell Sorting (FACS), a cornerstone technique in immunology. With an inviting blend of technical detail and accessible language, the blog demystifies the differences between FACS and flow cytometry, elaborating on their shared principle of using fluorescence to isolate and analyse individual cells. The author offers an insider's view of how FACS is integral to her own research, particularly in studying cell types like microglia and macrophages in the context of strokes. While acknowledging the challenges and limitations inherent to the technique—such as the need for high numbers of viable cells and the loss of spatial information—the blog ultimately underscores the irreplaceable value of FACS in advancing our understanding of disease mechanisms and cellular functions. Find the original text, and narration here on our website. https://www.dementiaresearcher.nihr.ac.uk/blog-sorting-facs-from-fiction/ -- Dr Gaia Brezzo is a Research Fellow based within the UK Dementia Research Institute at The University of Edinburgh. Gaia's research focuses on understanding how immune alterations triggered by stroke shape chronic maladaptive neuroimmune responses that lead to post-stroke cognitive decline and vascular dementia. Raised in Italy, Gaia came to the UK to complete her undergraduate degree, and thankfully, stuck around. Gaia writes about her work and career challenges, when not biking her way up and down hills in Edinburgh. Follow Gaia on Twitter: @Gaia_Brezzo -- Enjoy listening? We're always looking for new bloggers, drop us a line. http://www.dementiaresearcher.nihr.ac.uk This podcast is brought to you in association with Alzheimer's Association, Alzheimer's Research UK, Alzheimer's Society and Race Against Dementia, who we thank for their ongoing support.

Science is all about rigorous testing, empirical evidence, and painstaking documentation, right? But even in the most state-of-the-art labs, you'll find researchers who hold on to quirky rituals, lucky charms, or, dare we say it, superstitions. In this podcast, Dr Yvonne Couch, Associate Professor at University of Oxford hosts a discussion that romps through the lighter side of scientific research by exploring the wonderful world of lab superstitions. From lucky pipettes to forbidden phrases, we're about to uncover the unofficial 'do's and don'ts' that researchers swear by, or at least, swear make for good anecdotes. -- This shows guests are: Dr Kamar Ameen-Ali, Lecturer in Biomedical Science at Teeside University. In addition to teaching, Kam is interested in How neuroinflammation following traumatic brain injury contributes to the progression of neurodegenerative diseases (such as Alzheimer's disease) that lead to dementia. Dr Soraya Meftah, Postdoctoral Research Fellow in the UK Dementia Research Institute at The University of Edinburgh. Soraya works in the space of Neurophysiology of dementia (synaptic, neuronal, network dysfunction). Tabitha Broadbelt just completed her PhD at The University of Edinburgh and is now a Postdoctoral Researcher at the MRC Brain Network Dynamics Unity at University of Oxford. In the Dupret Group, Tabitha uses optogenetics and large-scale single-unit recordings combined to study memory-guided behaviour. Dr Lauren Walker is an Alzheimer's Research UK Fellow at Newcastle University. Lauren complete her undergrad degree in Physiological Sciences, and worked in a technical role for 7 years before being inspired to return to study a PhD. Lauren now works in Neuropathology of Lewy body dementia and Alzheimer's disease. -- Full biographies on all our guests and a transcript can be found on our website https://www.dementiaresearcher.nihr.ac.uk -- Like what you hear? Please review, like, and share our podcast - and don't forget to subscribe to ensure you never miss an episode – and if you prefer to watch rather than listen, you'll find a video version of this podcast with full captions on our YouTube Channel -- This podcast is brought to you by University College London / UCLH NIHR Biomedical Research Centre in association with Alzheimer's Association, Alzheimer's Research UK, Alzheimer's Society and Race Against Dementia who we thank for their ongoing support.

Dr Gaia Brezzo narrates her blog written for Dementia Researcher. In this blog Gaia shares what she has learned to help manage the complexities of academic authorship, highlighting its importance for both early career researchers and principal investigators. She outlines the roles of first, last, and co-authors, and advises on handling the often grey areas in contribution recognition. Emphasising the need for open communication, Gaia provides tips for avoiding disputes and stresses the importance of trust and equitable recognition in academic collaborations. Find the original text, and narration here on our website. https://www.dementiaresearcher.nihr.ac.uk/guest-blog-beyond-the-manuscript-disentangling-academic-authorship/ -- Dr Gaia Brezzo is a Research Fellow based within the UK Dementia Research Institute at The University of Edinburgh. Gaia's research focuses on understanding how immune alterations triggered by stroke shape chronic maladaptive neuroimmune responses that lead to post-stroke cognitive decline and vascular dementia. Raised in Italy, Gaia came to the UK to complete her undergraduate degree, and thankfully, stuck around. Gaia writes about her work and career challenges, when not biking her way up and down hills in Edinburgh. Follow Gaia on Twitter: @Gaia_Brezzo -- Enjoy listening? We're always looking for new bloggers, drop us a line. http://www.dementiaresearcher.nihr.ac.uk This podcast is brought to you in association with Alzheimer's Association, Alzheimer's Research UK, Alzheimer's Society and Race Against Dementia, who we thank for their ongoing support.

According to the World Health Organization, dementia currently affects an estimated 55 million people worldwide. But despite its prevalence, there is very little in the way of effective treatments. In this episode we catch up with Tara Spires-Jones, Professor at the UK Dementia Research Institute at the University of Edinburgh and President of the British Neuroscience Association. She tells us all about the different types of dementia, how they progress and the latest thinking on how we can beat the disease once and for all. Learn more about your ad choices. Visit podcastchoices.com/adchoices

Dr Gaia Brezzo narrates her blog written for Dementia Researcher. Exploring the domain of collaborative science, this blog delves into the progression of research dynamics from individual efforts to team collaborations. It emphasises the vital role of interpersonal relationships within laboratories and the significance of harmonising with a supportive lab environment. Gaia provides practical insights, spanning the evaluation of principal investigators to conflict resolution, the cultivation of transparent communication, and the nurturing of mentorship connections. Find the original text, and narration here on our website. https://www.dementiaresearcher.nihr.ac.uk/guest-blog-navigating-collaborative-science/ -- Dr Gaia Brezzo is a Research Fellow based within the UK Dementia Research Institute at The University of Edinburgh. Gaia's research focuses on understanding how immune alterations triggered by stroke shape chronic maladaptive neuroimmune responses that lead to post-stroke cognitive decline and vascular dementia. Raised in Italy, Gaia came to the UK to complete her undergraduate degree, and thankfully, stuck around. Gaia writes about her work and career challenges, when not biking her way up and down hills in Edinburgh. Follow Gaia on Twitter: @Gaia_Brezzo -- Enjoy listening? We're always looking for new bloggers, drop us a line. http://www.dementiaresearcher.nihr.ac.uk This podcast is brought to you in association with Alzheimer's Association, Alzheimer's Research UK, Alzheimer's Society and Race Against Dementia, who we thank for their ongoing support.

In this podcast we share a few selected highlights from the first day of the Alzheimer's Association International Conference (AAIC) taking place in Amsterdam and Online, 16th – 20th July. Adam Smith hosts the show with special guests Dr Mizuki Morisaki from University of Bristol, Sam Keat, PhD Student in the UK Dementia Research Institute at Cardiff University and Dr Arunima Sikdar a Postdoc Research Associate from University of North Carolina. -- The AAIC brings together distinguished basic scientists, clinical researchers, early career investigators, clinicians and the care research community at the largest and most influential international conference on dementia science. They share theories and breakthroughs while exploring opportunities to accelerate work and elevate careers. For more information visit: https://aaic.alz.org -- You can also enjoy this show as a video podcast on our YouTube Channel. -- Find more information on our guests, and a full transcript of this podcast on our website at: www.dementiaresearcher.nihr.ac.uk/podcast -- The views and opinions expressed by guests in this podcast represent those of the guests and do not necessarily reflect those of NIHR Dementia Researchers, PIA membership, ISTAART or the Alzheimer's Association.

In this episode, join our host Marcel as he delves deeper into his conversation with Dr. Jernej Ule, Centre Director at the UK Dementia Research Institute at King's College London as well as group leader at the Francis Crick Institute London and at the University of Ljubljana. They further discuss Dr. Ule's research on RNA-protein interactions in the cell and how this relates to development and disease. Dr. Ule also shares how he coordinates three labs across two countries and how this allows him to pursue his diverse research interests, bridging experimental and computational work.   To find out more about Dr. Jernej Ule's work check out: https://www.ulelab.info/ Ule lab Twitter: @ule_lab Remember to follow us on: Twitter: https://twitter.com/MPPhdnetPodcast Instagram: https://www.instagram.com/offspringmagazine_thepodcast LinkedIn: https://www.linkedin.com/company/offspring-magazine-the-podcast YouTube: https://youtube.com/c/MaxPlanckPhDnet For feedback, comments, or suggestions, reach out to us at offspring.podcasts@phdnet.mpg.de.  Check out our Offspring Blog for more content: https://www.phdnet.mpg.de/outreach/offspring-blog Intro & Outro music composed by Srinath Ramkumar: https://twitter.com/srinathramkumar Pre-Intro jingle composed by Gustavo Carrizo: https://www.instagram.com/carrizo.gus See you soon!

In this episode, join our host Marcel as he speaks with Dr. Jernej Ule, Centre Director at the UK Dementia Research Institute at King's College London as well as group leader at the Francis Crick Institute London and at the University of Ljubljana. They discuss Dr. Ule's personal journey in science - including a brotherly collaboration early in his career - and how he got interested in studying RNA networks in the brain.  Dr. Ule and Marcel discuss CLIP, a method to characterise RNA-protein interactions, and how this relates to the study of evolution, development and disease. Interestingly, the non-coding regions of RNAs, called introns, seem to play a critical role in these interactions, creating a “field of potentiality in our genome” as Dr. Ule describes it. To find out more information about Dr. Jernej Ule check out: https://www.ulelab.info/ Ule lab Twitter: @ule_lab Remember to follow us on: Twitter: https://twitter.com/MPPhdnetPodcast Instagram: https://www.instagram.com/offspringmagazine_thepodcast LinkedIn: https://www.linkedin.com/company/offspring-magazine-the-podcast YouTube: https://youtube.com/c/MaxPlanckPhDnet For feedback, comments, or suggestions, reach out to us at offspring.podcasts@phdnet.mpg.de.  Check out our Offspring Blog for more content: https://www.phdnet.mpg.de/outreach/offspring-blog Intro & Outro music composed by Srinath Ramkumar: https://twitter.com/srinathramkumar Pre-Intro jingle composed by Gustavo Carrizo: https://www.instagram.com/carrizo.gus See you soon!

Dr Mark Crook-Rumsey narrates his blog written for Dementia Researcher. Motor Neuron Disease (MND) is a complex and challenging neurodegenerative disease, in this blog Mark discusses the UK DRI work on the development of digital biomarkers through remote monitoring technologies, showing they have the potential to revolutionise MND research, enabling real-time, non-invasive data collection, improving disease understanding, facilitating more effective treatments, and enhancing the quality of life for patients. Find the original text, and narration here on our website. https://www.dementiaresearcher.nihr.ac.uk/guest-blog-digital-biomarkers-a-new-era-in-mnd-research-and-care/ -- Dr Mark Crook-Rumsey is a Postdoctoral Research Associate at the UK Dementia Research Institute. His role is to bridge the gap between the two centres and combine the technology developed at Imperial College London's Care Research and Technology Centre with the clinical expertise in motor neurone disease at King's College London. His current focus being digital biomarkers for Motor Neuron Disease (MND). -- Enjoy listening and reading our blogs? We're always on the look out for new contributors, drop us a line and share your own research and careers advice dementiaresearcher@ucl.ac.uk This podcast is brought to you in association with Alzheimer's Association, Alzheimer's Research UK, Alzheimer's Society and Race Against Dementia, who we thank for their ongoing support.

Dr Gaia Brezzo narrates her blog written for Dementia Researcher. In this blog Gaia discusses the struggle of balancing multiple aspects of an academic career, highlighting the need for personal and career development, and emphasising the importance of taking time for higher-level thinking and skill development. Find the original text, and narration here on our website. https://www.dementiaresearcher.nihr.ac.uk/guest-blog-searching-for-the-whole-scientist-juggling-academia/ -- Dr Gaia Brezzo is a Research Fellow based within the UK Dementia Research Institute at The University of Edinburgh. Gaia's research focuses on understanding how immune alterations triggered by stroke shape chronic maladaptive neuroimmune responses that lead to post-stroke cognitive decline and vascular dementia. Raised in Italy, Gaia came to the UK to complete her undergraduate degree, and thankfully, stuck around. Gaia writes about her work and career challenges, when not biking her way up and down hills in Edinburgh. Follow Gaia on Twitter: @Gaia_Brezzo -- Enjoy listening? We're always looking for new bloggers, drop us a line. http://www.dementiaresearcher.nihr.ac.uk This podcast is brought to you in association with Alzheimer's Association, Alzheimer's Research UK, Alzheimer's Society and Race Against Dementia, who we thank for their ongoing support.

Ask Your Mentor Podcast, from Dementia Researcher, in association with Alzheimer's Research UK (ARUK). Mentees interviewing their mentors, talking careers, lessons learned and what they've discovered, that could help you forge a successful career in dementia research. In this podcast experienced postdoc researcher Dr Nikoleta Daskoulidou from the UK Dementia Research Institute at Cardiff University interviews her mentor Heather Mortiboys, Professor of Cellular Neuroscience and Metabolism at The University of Sheffield. Nikoleta's research interests include the role of innate immunity and neuroinflammation in the development of Alzheimer's disease. She is fascinated by the complement system and its critical role in AD pathogenesis that makes it a potential therapeutic target. She also tells us that she drinks way too much coffee, collects old stuf, and raising money for dementia charties (this include a planned skydive). Heather studies Mitochondria and associated pathways in patient derived cells from patients with neurodegenerative diseases, Parkinson's Disease, Alzheimer's Disease and Motor Neuron Disease. Understanding phenotypes, the mechanisms leading to them and how they can be rescued for therapeutic effect. Outside work she is a mum of 2 boys, she loves long walks and a pub lunches, as well as watching sports. Full biographies on all our guests and a transcript can be found on our website ⁠https://www.dementiaresearcher.nihr.ac.uk⁠ Find our more about Alzheimer's Research UK and how they support early career researchers on their website: ⁠https://www.alzheimersresearchuk.org/research/for-researchers/ecr/supporting-your-career/⁠ Like what you hear? Please review, like, and share our podcast - and don't forget to subscribe to ensure you never miss an episode – and if you prefer to watch rather than listen, you'll find a video version of this podcast in Spotify and on our YouTube Channel at https://podfollow.com/ask-your-mentor This podcast is brought to you by University College London / UCLH NIHR Biomedical Research Centre in association with Alzheimer's Association, Alzheimer's Research UK, Alzheimer's Society and Race Against Dementia who we thank for their ongoing support. 00:00 Introduction 00:21 Meet the guests 02:17 Run through Heather's CV and Career 41:28 Speedy Career & Life Tips 45:20 Throughs on Mentoring & Roundup --- Send in a voice message: https://podcasters.spotify.com/pod/show/askyourmentor/message

Ask Your Mentor Podcast, from Dementia Researcher, in association with Alzheimer's Research UK (ARUK). Mentees interviewing their mentors, talking careers, lessons learned and what they've discovered, that could help you forge a successful career in dementia research. In this podcast Dr Melissa Salazar from University College London interviews Dr Steven Quinn, Senior Lecturer & Alzheimer's Research UK Fellow from University of York. Melissa is a Postdoctoral Research Fellow based in the UK Dementia Research Institute at University College London. She is a scientist with +10 years of research experience, who is specialised in sequencing methods and data analysis to study the genetics of Alzheimer's and Parkinson's disease. Steve is a Senior Lecturer & Alzheimer's Research UK Fellow at University of York. Steve obtained his MPhys in Physics from the University of St. Andrews and an MSc in Radiation, Oncology and Biology from the University of Oxford. After his PhD (St Andrews) and a postdoctoral position at the University of Glasgow, he took up a Lindemann Fellowship at the Massachusetts Institute of Technology (MIT) in the USA and in 2017, he was appointed to a Lectureship at the University of York and was awarded an Alzheimer's Research UK Fellowship in 2019. Steve is now a Senior Lecturer, and his group uses microscopy techniques to interrogate the structure, dynamics and function of single biomolecules implicated in dementia. Full biographies on all our guests and a transcript can be found on our website ⁠⁠https://www.dementiaresearcher.nihr.ac.uk⁠⁠ Find our more about Alzheimer's Research UK and how they support early career researchers on their website: ⁠⁠https://www.alzheimersresearchuk.org/research/for-researchers/ecr/supporting-your-career/⁠⁠ Like what you hear? Please review, like, and share our podcast - and don't forget to subscribe to ensure you never miss an episode – and if you prefer to listen rather than watch, you'll find an audio version of this podcast at ⁠https://podfollow.com/ask-your-mentor⁠ This podcast is brought to you by University College London / UCLH NIHR Biomedical Research Centre in association with Alzheimer's Association, Alzheimer's Research UK, Alzheimer's Society and Race Against Dementia who we thank for their ongoing support. --- Send in a voice message: https://podcasters.spotify.com/pod/show/askyourmentor/message

Welcome to another captivating episode of Dementia Researcher, the podcast that delves into the fascinating world of dementia research. In this special edition, we bring you highlights from the renowned BNA 2023 - Festival of Neuroscience, as we sit down with five brilliant researchers to hear their personal experiences and insights. Our guest host this week is Dr Kamar Ameen-Ali, she is joined by Dr Charlie Arber from UCL, Dr Dorothy Tse from Edge Hill University, Dr Nora Bengoa-Vergniory from Anchucarro, Basque Center for Neuroscience and Dr Dayne Beccano-Kelly from the UK Dementia Research Institute at Cardiff University. Join us as we embark on a riveting journey through the festival, where our guests share their best moments, favourite research presentations, and the exciting events that explored academic and research careers. Our guests, as experts in their respective fields, paint a vivid picture of the festival, offering glimpses into the cutting-edge research that caught their attention and ignited their curiosity. They share their thoughts on the emerging trends, innovative methodologies, and potential breakthroughs that could revolutionize our understanding and treatment of dementia. But it's not just about the science. Our guests also shine a light on the various events that focused on academic and research careers. From panels and workshops to networking sessions, they discuss the invaluable opportunities the festival provided to connect with fellow researchers, forge collaborations, and learn from the brightest minds in the field. Whether you're an aspiring researcher, a healthcare professional, or someone affected by dementia, this episode offers a treasure trove of knowledge and inspiration. So, join us as we dive into the enriching world of the BNA 2023 - Festival of Neuroscience through the eyes of these remarkable researchers. Get ready to be inspired, informed, and captivated by the incredible discoveries and the unwavering dedication that fuels the fight against dementia. -- For more information on the event visit: https://meetings.bna.org.uk/bna2023/ Full biographies on all our guests and a transcript can be found on our website: https://www.dementiaresearcher.nihr.ac.uk -- Like what you hear? Please review, like, and share our podcast - and don't forget to subscribe to ensure you never miss an episode – and if you prefer to watch rather than listen, you'll find a video version of this podcast on our YouTube Channel and in Spotify: https://youtu.be/Wi1htbbMsek -- This podcast is brought to you by University College London / UCLH NIHR Biomedical Research Centre in association with Alzheimer's Association, Alzheimer's Research UK, Alzheimer's Society and Race Against Dementia who we thank for their ongoing support.

Dr Gaia Brezzo narrates her blog written for Dementia Researcher. Are you tired of the witchcraft and frustration of Western Blotting? Learn the basics of this technique and how it can benefit your research in this new blog from Gaia. Find out how to select the right sample, run a successful gel electrophoresis, transfer proteins, and quantify the results. Discover tips and tricks from a researcher who's been there. Don't let Western Blotting intimidate you anymore, read our blog now!" Find the original text, and narration here on our website. https://www.dementiaresearcher.nihr.ac.uk/guest-blog-the-blot-thickens-using-western-blotting-in-research/ -- Dr Gaia Brezzo is a Research Fellow based within the UK Dementia Research Institute at The University of Edinburgh. Gaia's research focuses on understanding how immune alterations triggered by stroke shape chronic maladaptive neuroimmune responses that lead to post-stroke cognitive decline and vascular dementia. Raised in Italy, Gaia came to the UK to complete her undergraduate degree, and thankfully, stuck around. Gaia writes about her work and career challenges, when not biking her way up and down hills in Edinburgh. Follow Gaia on Twitter: @Gaia_Brezzo -- Enjoy listening? We're always looking for new bloggers, drop us a line. http://www.dementiaresearcher.nihr.ac.uk This podcast is brought to you in association with Alzheimer's Association, Alzheimer's Research UK, Alzheimer's Society and Race Against Dementia, who we thank for their ongoing support.

Consider this podcast as a ‘Lab Setup 101”, we've brought together three newly minted principle investigators to talk about the highs, lows and practical things you need to consider when setting up a new lab – learning from their first-hand experience. Dr Fiona McLean, ARUK Fellow from University of Dundee talks with Dr Claire Durrant, RAD Fellow from The University of Edinburgh, Dr Ian Harrison, Senior Research Fellow from University College London and Dr Dayne Beccano-Kelly, Group Leader in the UK Dementia Research Institute at Cardiff University. Together our guests will guide you through the important things you need to know before embarking on this journey. Everything from locations and space to purchasing equipment, and hiring staff, we'll cover everything you need to get started. Our expert guests will also share their experiences and provide valuable insights to help you avoid common pitfalls and ensure a successful lab setup. So, join us as we explore the essentials of setting up your own lab. -- Meet the guests: Dr Fiona McLean is an Alzheimer's Research UK Fellow at University of Dundee. She is fascinated by the brain and has always been curious about how it works and what keeps it healthy. Her research focuses on the links between obesity, diabetes and neurodegenerative diseases. Dr Claire Durrant is a Race Aganinst Dementia / Dyson Foundation Fellow in the UK Dementia Research Institute at The University of Edinburgh. Her work focuses on understanding the causes and consequences of synapse loss in dementia causing disease such as Alzheimer's disease. She is currently developing living human brain slices as a translational research tool. Dr Ian Harrison is a Senior Research Fellow at University College London. His work looks at the function of the glymphatic system in the brain, responsible for the clearance of protein solutes from the brain parenchyma. Dr Dayne Beccano-Kelly is UKRI Future Leader Fellow and UK Dementia Research Institute Group Leader at Cardiff University. He is working on neurodegeneration focussing on Parkinson's disease and looking at both the temporality of the disorder as well as the role synaptic dysfunction plays. -- Like what you hear? Please review, like, and share our podcast - and don't forget to subscribe to ensure you never miss an episode – and if you prefer to watch rather than listen, you'll find a video version of this podcast with full captions on our YouTube Channel – www.youtube.com/dementiaresearcher -- This podcast is brought to you by University College London / UCLH NIHR Biomedical Research Centre in association with Alzheimer's Association, Alzheimer's Research UK, Alzheimer's Society and Race Against Dementia who we thank for their ongoing support.

This year's AD/PD Conference was held in Gothenburg, Sweden from the 28th March to 1st April. In this first of a two-part special we bring you highlights from the first three days of the conference. The AD/PD Conference focuses on basic science and translational and clinical research bringing New insights on disease mechanisms and etiologies, the latest findings from clinical trials, innovative outlooks on therapy and prevention and advances in diagnostic markers. In this special on-location recording our guest host Dr Nikoleta Daskoulidou, Research Associate from the UK Dementia Research Institute at Cardiff University talks with: Dr David J. Koss, Research Associate from Newcastle University. David is working to understand the molecular pathology which underpins a range of neurodegenerative dementias. Dr Susan Mitchell, Head of Policy at Alzheimer's Research UK. Susan is part of the ARUK policy and public affairs team, with responsibility for developing evidence-based policy to ensure people affected by dementia benefit from the progress in research. Elizabeth English, PhD Student at University of Cambridge. Lizzie, is utilising biophysical methods to characterise protein aggregates and their toxicity mechanisms in neurodegenerative disease. For more information on the event visit: https://adpd.kenes.com/ Full biographies on all our guests and a transcript can be found on our website: https://www.dementiaresearcher.nihr.ac.uk Like what you hear? Please review, like, and share our podcast - and don't forget to subscribe to ensure you never miss an episode – and if you prefer to watch rather than listen, you'll find a video version of this podcast on our YouTube Channel https://youtu.be/UQdm8aWuoFM This podcast is brought to you by University College London / UCLH NIHR Biomedical Research Centre in association with Alzheimer's Association, Alzheimer's Research UK, Alzheimer's Society and Race Against Dementia who we thank for their ongoing support.

This year's AD/PD Conference was held in Gothenburg, Sweden from the 28th March to 1st April. In this second of a two-part special we bring you highlights from last three days of the conference. The AD/PD Conference focuses on basic science and translational and clinical research bringing New insights on disease mechanisms and etiologies, the latest findings from clinical trials, innovative outlooks on therapy and prevention and advances in diagnostic markers. In this special on-location recording our guest host Dr Anna Mallach, Research Fellow from the UK Dementia Research Institute at University College London talks with: Dr Melissa Scholefield, Postdoctoral Research Associate at University of Manchester. Melissa focusses on undertaking Multi-omic analysis of Lewy body dementias. Dr Chi Udeh-Momoh, Research Programme and Biomarker Lead at Imperial College London. Chi has always been fascinated by the brain, how we think, learn and remember; and how these processes can be affected in disease/ alleviated therapeutically. Emily McCann, PhD Student at Queensland Brain Institute, University of Queensland. Emily's research is in cognitive test development for neurodegenerative diseases. She aims to align functional neural changes with the patient cognitive profile, and has developed a series of tests to measure visuoperceptual impairments in patients with Alzheimer's and Lewy Body pathology. For more information on the event visit: https://adpd.kenes.com/ Full biographies on all our guests and a transcript can be found on our website: https://www.dementiaresearcher.nihr.ac.uk Like what you hear? Please review, like, and share our podcast - and don't forget to subscribe to ensure you never miss an episode – and if you prefer to watch rather than listen, you'll find a video version of this podcast on our YouTube Channel and in Spotify: https://youtu.be/W8kj7PqHz98 This podcast is brought to you by University College London / UCLH NIHR Biomedical Research Centre in association with Alzheimer's Association, Alzheimer's Research UK, Alzheimer's Society and Race Against Dementia who we thank for their ongoing support.

Welcome to this episode of our podcast co-hosted by researchers Dr Gaia Brezzo and Mila Redzic, they our special guests sharing their inspiring story of resilience and hope. Today, we are joined by Denis and his daughter Maise, they became connected to Gaia and Mila after Denis experienced a life-altering event - a stroke. Together they share their personal journey of what it was like to have a stroke, the impact on the family, the challenges they faced during their recovery, and how they adapted to their new normal. They will also be sharing their journey of becoming involved in stroke research, the importance of research in stroke recovery, and how it has impacted their life. Through their story, we hope to shed light on the impact of stroke and the importance of research in advancing stroke care, its connections to dementia and the importance of improving the quality of life for stroke survivors. Please join us in welcoming our guest as they share their unique and inspiring journey. -- If you're interested in participating in a research study, and based in the UK, Join Dementia Research supports people of all ages, both with an without dementia to be matched with appropriate studies. Registration is free, and you can even register on behalf of someone who is unable to do so themselves. Visit https://www.joindementiaresearch.nihr.ac.uk if you live outside the UK, there may be a similar service in your region e.g. Trial Match in the USA, and Stepup For Dementia Research in Australia. -- Our hosts this week are: Dr Gaia Brezzo, Research Fellow in Cerebral Vascular Disease and Dementia at the UK Dementia Research Institute at The University of Edinburgh. Gaia's research focuses on understanding how immune alterations triggered by stroke shape chronic maladaptive neuroimmune responses that lead to post-stroke cognitive decline and vascular dementia. Mila Redzic, PhD Student at The University of Edinburgh. Mila is interested in understanding how microglial responses may shape changes occurring in the neurovascular unit in this context, and whether we can manipulate microglia to promote brain resilience and reduce cognitive impairment. -- Full biographies on the hosts and our guests, and a transcript can be found on our website https://www.dementiaresearcher.nihr.ac.uk -- Stroke is a serious medical condition that occurs when blood flow to the brain is interrupted, which can lead to brain damage. This damage can result in a range of cognitive problems, including dementia. Studies have shown that people who have had a stroke are at a higher risk of developing various forms of dementia, such as vascular dementia and Alzheimer's disease. The risk of dementia is particularly high in individuals who have had a stroke that affects a large part of the brain or who have had multiple strokes. In addition, many of the risk factors that increase the likelihood of having a stroke, such as high blood pressure, diabetes, and heart disease, also increase the risk of developing dementia. It's important to note that not everyone who has a stroke will develop dementia, and there are steps you can take to reduce your risk. Managing risk factors for stroke, such as maintaining a healthy diet and exercise routine, quitting smoking, and controlling blood pressure and cholesterol levels, can also help reduce the risk of dementia. -- Like what you hear? Please review, like, and share our podcast - and don't forget to subscribe to ensure you never miss an episode – and if you prefer to watch rather than listen, you'll find a video version of this podcast with full captions on our YouTube Channel – http://www.youtube.com/dementiaresearcher -- This podcast is brought to you by University College London / UCLH NIHR Biomedical Research Centre in association with Alzheimer's Association, Alzheimer's Research UK, Alzheimer's Society and Race Against Dementia who we thank for their ongoing support.

This week, Claire chatted to Maitreyee Wairagkar from the University of California all about neurotechnology, artificial intelligence, and assistive robotics.  Maitreyee Wairagkar is a postdoctoral fellow at University of California, Davis, developing assistive neurotechnology using artificial intelligence to restore lost function in people with neurological disorders. She builds brain-computer interfaces to enable people with severe motor and speech impairments to communicate directly via their brain signals by breaking barriers between humans and technology. Previously, she was at Imperial College London and UK Dementia Research Institute where she developed conversational AI and social robots for dementia support.

Dr Gaia Brezzo narrates her blog written for Dementia Researcher. Work smarter not harder – I am sure you have heard this phrase before. And if you work in academia, like Gaia, I am sure you probably shrugged it off, most likely thinking I need to work smarter AND harder. But do we really? And where does this working ethos come from? In this blog Gaia talks about the 4-day working week movement that has really taken traction following the pandemic, the remarkable benefits working a shorter week can bring for employees and employers and discuss if this could really work in academia and if so, what it would look like.   Find the original text, and narration here on our website. https://www.dementiaresearcher.nihr.ac.uk/guest-blog-moving-four-ward-could-a-4-day-working-week-work-in-academia/ -- Dr Gaia Brezzo is a Research Fellow based within the UK Dementia Research Institute at The University of Edinburgh. Gaia's research focuses on understanding how immune alterations triggered by stroke shape chronic maladaptive neuroimmune responses that lead to post-stroke cognitive decline and vascular dementia. Raised in Italy, Gaia came to the UK to complete her undergraduate degree, and thankfully, stuck around. Gaia writes about her work and career challenges, when not biking her way up and down hills in Edinburgh. Follow Gaia on Twitter: @Gaia_Brezzo -- Enjoy listening? We're always looking for new bloggers, drop us a line. http://www.dementiaresearcher.nihr.ac.uk This podcast is brought to you in association with Alzheimer's Association, Alzheimer's Research UK, Alzheimer's Society and Race Against Dementia, who we thank for their ongoing support.

Last week we were in Aberdeen for the Alzheimer's Research UK Conference 2023 to hear the latest findings in dementia research. In the second of our two-part special we focus on sharing highlights from the main conference, which featured two days of brilliant scientific programming. Guest host Dr Zara Franklin from University of Aberdeen talks with Dr Natalie Connor-Robson from the UK Dementia Research Institute at Cardiff University, Dr Szu-Han Wang from The University of Edinburgh and Dr Steven Quinn from University of York. Full biographies on all our guests and a transcript can be found on our website: https://www.dementiaresearcher.nihr.ac.uk -- Like what you hear? Please review, like, and share our podcast - and don't forget to subscribe to ensure you never miss an episode – and if you prefer to watch rather than listen, you'll find a video version of this podcast with full captions on our YouTube Channel: https://www.youtube.com/dementiaresearcher -- This podcast is brought to you by University College London / UCLH NIHR Biomedical Research Centre in association with Alzheimer's Association, Alzheimer's Research UK, Alzheimer's Society and Race Against Dementia who we thank for their ongoing support.

Great progress has been made over the past decade in the development of blood based bio-markers to diagnose Alzheimer's disease and other forms of dementia. However, other areas have been quietly working away, and have also made significant progress. In this podcast we explore two of the newest and most innovative technologies being applied to detect biomarkers for dementia – looking at the retina and brainwaves. Dr Amanda Heslegrave, Senior Research Fellow at the UK Dementia Research Institute, University College London and one of the people behind the progress being made in blood-based biomarker field is out guest host. This weeks guests are: Dr Catherine Bornbaum, Head of Clinical Operations and Partnerships at Retispec. Catherine, uses innovative imaging technology combined with robust machine learning and artificial intelligence (AI) to detect biomarkers of neurodegenerative disease throughout the eye. The eye provides a simple and non-invasive way to measure the central nervous system; it is also the only organ where both neurons and blood vessels can be directly visualized at micron-level resolution. Dr George Stothart, Senior Lecturer at University of Bath. George is a cognitive neuroscientist who translates the findings of cognitive neuroscience into useful tools for clinicians and the wider world. His primary research focus is the development of a new EEG technique, known as Fastball, for the assessment of cognitive deficits in dementia. Fastball EEG is a completely passive test which measures brain waves the patient looks at a series of images on a computer screen over two minutes – a completely new assessment technique. -- For more information visit: https://www.retispec.com/ https://www.bath.ac.uk/projects/fastball-mci/ -- Full biographies on all our guests and a transcript can be found on our website https://www.dementiaresearcher.nihr.ac.uk -- Like what you hear? Please review, like, and share our podcast - and don't forget to subscribe to ensure you never miss an episode – and if you prefer to watch rather than listen, you'll find a video version of this podcast with full captions on our YouTube Channel – http://www.youtube.com/dementiaresearcher -- This podcast is brought to you by University College London / UCLH NIHR Biomedical Research Centre in association with Alzheimer's Association, Alzheimer's Research UK, Alzheimer's Society and Race Against Dementia who we thank for their ongoing support.

Dr. Axel Montagne is a chancellor's fellow and group leader at the UK Dementia Research Institute at the University of Edinburgh Centre for Clinical Brain Sciences. His group aims to understand how, when, and where critical components of the blood-brain barrier become dysfunctional preceding dementia and in the earliest stages of age-related cognitive decline. With this knowledge, they hope to develop precise treatments targeting brain vasculature to protect brain function. More importantly his work, and that of his colleagues, provide a critical lens through which to view the contributions of vascular dysfunction (or, conversely, vascular health – if we choose to preserve it) as a critical common thread in dementia and neurodegeneration. In this episode, we discuss: 11:44 - What dementias have in common 12:42 - The importance of preserving small blood vessels (in the brain) 13:38 - Changes in the blood-brain barrier in aging that cause "leaking" 15:11 - Predicting cognitive decline early with biomarkers – an opportunity for intervention? 16:32 - Why targeting amyloid isn't enough 18:54 - The impact of the APOE4 genotype on brain vasculature 24:19 - The cause of white matter damage in the brain 33:47 - Why the loss of omega-3 transport affects pericytes 35:25 - The role of exercise in prevention of blood-brain barrier dysfunction 35:45 - Why high heart rates during exercise preserve brain function 36:49 - The role of exercise in preserving vision health 40:17 - Why leaky vessels damage myelin and the brain 45:31 - Can you have more than one type of dementia? 47:54 - Does the breakdown of the blood-brain barrier cause “type 3 diabetes"? 54:03 - Why omega-3 may prevent detachment of pericytes 01:14:35 - Why a hepatitis drug restored cognition in APOE4 mice 01:19:39 - Why blood-brain barrier disruption results in the accumulation of amyloid-beta 01:25:14 - Why lifetime hypertension increases dementia risk 01:37:13 - Effects of obesity on blood-brain barrier leakage Watch this episode on YouTube Show notes are available by clicking here Join over 300,000 people and get the latest distilled information straight to your inbox weekly: https://www.foundmyfitness.com/newsletter Become a FoundMyFitness premium member to get access to exclusive episodes, emails, live Q+A's with Rhonda and more: https://www.foundmyfitness.com/premium Learn more about the premium podcast The Aliquot: https://www.foundmyfitness.com/aliquot

Dr Gaia Brezzo narrates her blog written for Dementia Researcher. Good researchers evaluate data from every angle. They explore cause and effect and untangle the tricky web that interconnects everyday phenomena. So it is easy to understand why Gaia has found it difficult to decide where she stands when it comes to the decision around if she should or shouldn't participate in the industrial action voted on by University & College Union members in a dispute with Universities over pensions, pay and conditions. In this blog Gaia sets out the issues and shares her thoughts on the challenges, the points of dispute and how to respond.  Find the original text, and narration here on our website. https://www.dementiaresearcher.nihr.ac.uk/guest-blog-to-cross-or-not-to-cross-the-picket-line-striking-as-an-ecr/ -- Dr Gaia Brezzo is a Research Fellow based within the UK Dementia Research Institute at The University of Edinburgh. Gaia's research focuses on understanding how immune alterations triggered by stroke shape chronic maladaptive neuroimmune responses that lead to post-stroke cognitive decline and vascular dementia. Raised in Italy, Gaia came to the UK to complete her undergraduate degree, and thankfully, stuck around. Gaia writes about her work and career challenges, when not biking her way up and down hills in Edinburgh. Follow Gaia on Twitter: @Gaia_Brezzo -- Enjoy listening? We're always looking for new bloggers, drop us a line. http://www.dementiaresearcher.nihr.ac.uk This podcast is brought to you in association with Alzheimer's Association, Alzheimer's Research UK, Alzheimer's Society and Race Against Dementia, who we thank for their ongoing support.

Over the past decade, blood-based biomarkers for dementia have been increasingly studied as way to diagnose and track the progress of Alzheimer's and other neurodegenerative diseases. In this podcast three leading blood-based biomarker pioneers come together to discuss the field, their research and motivations, current challenges and future directions of this field of research (they also reveal a little about themselves as people away from the lab too – find out which if them wants to drive refuse trucks…). In the host chair is Dr Nicholas Ashton, Associate Professor of Neurochemistry from University of Gothenburg and King's College London. Nicks has more than a decade of experience in biofluid analysis and assay development for Alzheimer's disease, which ranges from discovery mass spectrometry methods to ultra-sensitive immunoassays. Recently this has produced ultra-sensitive single molecular array (Simoa) assays for phosphorylated tau in blood, which are now widely used in research settings, therapeutics trials and being validated for clinical use. -- Nick's guests are: Oskar Hansson, Professor of Neurology & Senior Consultant in Neurology at Lund University in Sweden. Oskar explores fluid and imaging biomarkers for neurodegenerative disorders. His inspiration came at medical school when diagnosing dementias. It became clear to him that we needed to be able to identify these diseases before widespread neurodegeneration and disabling symptoms have already developed. At these early disease stages, we are more likely to substantially slow down or even stop the disease progression by different types of interventions. Henrik Zetterberg, Professor of Neurochemistry, Senior Consultant in Clinical Chemistry, Head of Department at UK Dementia Research Institute at University College London and University of Gothenburg. With a background in molecular biology and medicine, Henrik has have spent the last 15 years developing biomarkers for Alzheimer's disease and other brain disorders - becoming a world expert in the process. He has published more than 1100 scientific articles and has received numerous awards. -- If you're listening to this podcast, you probably already know that Biomarkers are proteins, molecules, or other measurable substances that can provide valuable insight into diagnosing and measuring the progression of a medical condition or disease. For a many years researchers have been exploring the potential of what can discover from blood, to help diagnose Alzheimer's and other Neurodegenerative diseases. -- You can find out more about our panellists, and their work on our website. There you will also find a full transcript: https://www.dementiaresearcher.nihr.ac.uk -- Like what you hear? Please review, like, and share our podcast - and don't forget to subscribe to ensure you never miss an episode. -- This podcast is brought to you by University College London / UCLH NIHR Biomedical Research Centre in association with Alzheimer's Association, Alzheimer's Research UK, Alzheimer's Society and Race Against Dementia who we thank for their ongoing support.

Dr Gaia Brezzo narrates her blog written for Dementia Researcher. It's from the comfort of her living room sofa that Gaia writes her final blog for 2022, cup of tea in hand and a purring cat on her lap as she taps away on the keyboard. This month, to round up 2022, Gaia decided to blog about what she has achieved – and not achieved – this year, as she reflects back on another year of her science and what – hopefully exiting stuff – 2023 could bring.  Find the original text, and narration here on our website. https://www.dementiaresearcher.nihr.ac.uk/guest-blog-reflections-for-2022-another-year-of-science/ -- Dr Gaia Brezzo is a Research Fellow based within the UK Dementia Research Institute at The University of Edinburgh. Gaia's research focuses on understanding how immune alterations triggered by stroke shape chronic maladaptive neuroimmune responses that lead to post-stroke cognitive decline and vascular dementia. Raised in Italy, Gaia came to the UK to complete her undergraduate degree, and thankfully, stuck around. Gaia writes about her work and career challenges, when not biking her way up and down hills in Edinburgh. Follow Gaia on Twitter: @Gaia_Brezzo -- Enjoy listening? We're always looking for new bloggers, drop us a line. http://www.dementiaresearcher.nihr.ac.uk This podcast is brought to you in association with Alzheimer's Research UK and Alzheimer's Society, who we thank for their ongoing support.

Professor John Hardy, group leader at the UK Dementia Research Institute at University College London & one of the world's foremost researchers into Alzheimer's disease on this breakthrough

Dr Gaia Brezzo narrates her blog written for Dementia Researcher. Gaia is planning to attend an early career (ECR) event in person early next month. Even as a postdoc with quite a few years of experience under her belt, she still has that niggling feeling of guilt when she takes time away from the lab and the foreboding anxious wait to see if it was actually worth it. In this blog Gaia shares her thoughts on attending these types of events, what can be gained from them, why some of us might feel guilty attending and some tips to help you decide if that ECR event really is worth your time.  Find the original text, and narration here on our website. https://www.dementiaresearcher.nihr.ac.uk/guest-blog-early-career-research-events-to-attend-or-not-to-attend/ -- Dr Gaia Brezzo is a Research Fellow based within the UK Dementia Research Institute at The University of Edinburgh. Gaia's research focuses on understanding how immune alterations triggered by stroke shape chronic maladaptive neuroimmune responses that lead to post-stroke cognitive decline and vascular dementia. Raised in Italy, Gaia came to the UK to complete her undergraduate degree, and thankfully, stuck around. Gaia writes about her work and career challenges, when not biking her way up and down hills in Edinburgh. Follow Gaia on Twitter: @Gaia_Brezzo -- Enjoy listening? We're always looking for new bloggers, drop us a line. http://www.dementiaresearcher.nihr.ac.uk This podcast is brought to you in association with Alzheimer's Research UK and Alzheimer's Society, who we thank for their ongoing support.

Sarah Tabrizi is Director of the UCL Huntington's Disease (HD) Centre, Joint Head of Department Neurodegenerative Disease at the UCL Queen Square Institute of Neurology, a Principal Investigator at the UK Dementia Research Institute, and Honorary Consultant Neurologist at the National Hospital for Neurology and Neurosurgery. She graduated in Biochemistry, then studied Medicine at the University of Edinburgh where she was awarded the 1992 Leslie Gold Medal for the most distinguished medical graduate. Sarah undertook her PhD and trained as an independent scientist at UCL, establishing a large basic bench science and translational research team focussed on finding disease modifying therapies for HD. She was PI on the first successful phase 1/2b trial of an antisense oligonucleotide (NEJM 2019) and currently serves on several SABs advising industry on the development of potential gene targeting and nucleic acid therapies for HD. Sarah has published over 350 peer-reviewed research papers. In 2014 she was elected as a Fellow of the UK Academy of Medical Sciences. In 2017 she received the seventh Leslie Gehry Brenner Prize for Innovation in Science awarded by the Hereditary Disease Foundation. In 2018 she received the Cotzias Award from the Spanish Society of Neurology, and in 2019 the Yahr Award at the World Congress for Neurology and the Alexander Morison Medal from the Royal College of Physicians of Edinburgh. In 2022, she received the Osler Medal from the Association of Physicians of Great Britain and Ireland.

Danielle Wilson narrates her blog written for Dementia Researcher. Works in the UK Dementia Research Institute, Care Research & Technology Group at Imperial College London. In this blog Danielle discusses her passion of tech research and its ability to augment care, and about some of the work being done within the UKDRI to drive this forward, at the cutting edge of support (if you enjoy this you should also check out our blog from Pippa Kirby who works within the DRI). Find the original text, and narration here on our website. https://www.dementiaresearcher.nihr.ac.uk/guest-blog-technology-to-help-care/ -- Danielle Wilson is a former acting director of a pre-eminent NHS centre conducting clinical trials & observational studies in across dementia & mental health conditions,  and is the current Centre and Research Commercialisation lead at UK Dementia Research Institute, Care Research & Technology at Imperial College London. Danielle has extensive clinical research experience working with the National Institute of Health Research networks, the University of Oxford, the National Health Service (including Oxford University Hospitals NHS FT), Clinical Research Organisations & global pharmaceutical companies. She has experience working across medical specialities in a variety of human clinical trials, tissue, imaging & data studies. Passionate about patient care, participant safety & research excellence. Invested in staff development; most recently developed & implemented a competency framework for clinical researchers. Danielle is also a Chair & long-standing expert member of a Health Research Authority research ethics committee leading a multidisciplinary group to review & give opinion on a broad range of studies, with particular specialism in applying knowledge of the mental capacity act to review research studies recruiting individuals who lack capacity. -- Enjoy listening? We're always looking for new bloggers, drop us a line. http://www.dementiaresearcher.nihr.ac.uk This podcast is brought to you in association with Alzheimer's Research UK and Alzheimer's Society, who we thank for their ongoing support.

Pippa Kirby, narrates her blog written for Dementia Researcher. There is no doubt that technology is dramatically changing the landscape of health and social care, and dementia care is no exception. Pippa's research is focused on exploring people with dementia's perceptions and experiences of smart home technology. ‘Smart homes' are one of the ways being proposed in which technology may be used to prevent hospitalisations and enable people to remain living in their own homes for longer. An appealing proposition perhaps, but a concept which can be divisive: will these systems promote independence and greater freedom, or is this Big Brother? It is important that we learn more about what people with dementia think of this type of home technology, and that their voices are central to the design and development of these systems so that the resulting services are ethical, engaging and effective. In this blog speech and language therapist Pippa discusses her research exploring how we can support the communication of people with speech, language and cognitive difficulties to engage with new innovative technology, and ensure they have as much of a place at the table as those without communication difficulties when it comes to design and delivery. Find the original text, and narration here on our website. https://www.dementiaresearcher.nihr.ac.uk/guest-blog-communicating-smart-technology/ -- Pippa Kirby is a Speech and Language Therapist and Pre-doctoral Clinical Research Fellow based within the UK Dementia Research Institute at Imperial College London. As a clinician Pippa became interested in how we empower and involve patients with communication difficulties in conversations and in decision making, this led to her current research within the UKDRI Care & Technology Centre, developing smart homes for people with dementia, and how to best explore and understand the perspectives of people with dementia, and involve them in the research. Enjoy listening and reading our blogs? We're always on the look out for new contributors, drop us a line and share your own research and careers advice dementiaresearcher@nihr.ac.uk

Dr Gaia Brezzo narrates her blog written for Dementia Researcher. In this month's blog, Gaia is reflecting back on a meeting she had with a member of the public earlier in the week. A stroke survivor, who has made it their goal to share with researchers, charities and funding bodies, their views and opinions. Sharing their lived experience of what it's like to live with the aftermath of a stroke. Gaia also explores how important these voices are in research and how, perhaps, we should all be considering how we could be doing more. Find the original text, and narration here on our website. https://www.dementiaresearcher.nihr.ac.uk/guest-blog-the-importance-of-lived-experience-in-research/ -- Dr Gaia Brezzo is a Research Fellow based within the UK Dementia Research Institute at The University of Edinburgh. Gaia's research focuses on understanding how immune alterations triggered by stroke shape chronic maladaptive neuroimmune responses that lead to post-stroke cognitive decline and vascular dementia. Raised in Italy, Gaia came to the UK to complete her undergraduate degree, and thankfully, stuck around. Gaia writes about her work and career challenges, when not biking her way up and down hills in Edinburgh. Follow Gaia on Twitter: @Gaia_Brezzo -- Enjoy listening? We're always looking for new bloggers, drop us a line. http://www.dementiaresearcher.nihr.ac.uk This podcast is brought to you in association with Alzheimer's Research UK and Alzheimer's Society, who we thank for their ongoing support.

Dr Gaia Brezzo narrates her blog written for Dementia Researcher. As Gaia mentioned in her first blog, she had a slightly different PhD experience to most. Her funding and course enrolment fees were paid for by a Teaching Fellowship. This provided four years in which to run experiments, write up a thesis and teach for up to 180 hours in her department every year. In this blog, Gaia explores how this joint research-teaching experience helped her as an ECR, shaped her research and career to date and opened up other avenues and opportunities along the way - it also includes a few tips on how to get teaching. Find the original text, and narration here on our website. https://www.dementiaresearcher.nihr.ac.uk/guest-blog-teaching-as-an-ecr-why-take-the-time-to-do-it/ -- Dr Gaia Brezzo is a Research Fellow based within the UK Dementia Research Institute at The University of Edinburgh. Gaia's research focuses on understanding how immune alterations triggered by stroke shape chronic maladaptive neuroimmune responses that lead to post-stroke cognitive decline and vascular dementia. Raised in Italy, Gaia came to the UK to complete her undergraduate degree, and thankfully, stuck around. Gaia writes about her work and career challenges, when not biking her way up and down hills in Edinburgh. Follow Gaia on Twitter: @Gaia_Brezzo -- Enjoy listening? We're always looking for new bloggers, drop us a line. http://www.dementiaresearcher.nihr.ac.uk This podcast is brought to you in association with Alzheimer's Research UK and Alzheimer's Society, who we thank for their ongoing support.

There's encouraging news about a potential treatment for Alzheimer's Disease following years of disappointing drug trials. The drug lecanemab is a monoclonal antibody which is designed to remove clumps of amyloid proteins which damage the brain. Professor Bart de Strooper who's director of the UK Dementia Research Institute explains how patients who had regular infusions of the drug had their rate of cognitive decline reduced by 27% when compared to those given a placebo. Sewage testing has been used around the world during the Covid pandemic – and at the moment children in London are being vaccinated against polio after the virus was found in waste water. The BBC's Health and Science Correspondent James Gallagher takes us on a tour of a sewer in southern England. Claudia Hammond's guest this week Professor Graham Easton from Queen Mary University of London looks at whether folic acid could reduce suicide and self harm – and whether it's ok to take anti-depressants during pregnancy. Presenter: Claudia Hammond Producer: Paula McGrath (Picture: Pharmaceutical research into brain disorders. Photo credit: Westend61/Getty Images.)

Dr Gaia Brezzo narrates her blog written for Dementia Researcher. We are delighted to welcome Dr Gaia Brezzo as a regular monthly blog contributor to the Dementia Researcher website. Gaia will be sharing stories of her research, field of discovery and providing top tips and careers advice coming from her experiences. Find the original text, and narration here on our website. https://www.dementiaresearcher.nihr.ac.uk/guest-blog-dr-gaia-brezzo-introduction/ -- Dr Gaia Brezzo is a Research Fellow based within the UK Dementia Research Institute at The University of Edinburgh. Gaia's research focuses on understanding how immune alterations triggered by stroke shape chronic maladaptive neuroimmune responses that lead to post-stroke cognitive decline and vascular dementia. Raised in Italy, Gaia came to the UK to complete her undergraduate degree, and thankfully, stuck around. Gaia writes about her work and career challenges, when not biking her way up and down hills in Edinburgh. Follow Gaia on Twitter: @Gaia_Brezzo -- Enjoy listening? We're always looking for new bloggers, drop us a line. http://www.dementiaresearcher.nihr.ac.uk This podcast is brought to you in association with Alzheimer's Research UK and Alzheimer's Society, who we thank for their ongoing support.

Each year 30 research scientists are paired with UK parliamentarians and civil servants. They learn about each other's work by spending time together in Westminster and the researcher's institutions. Those taking part gain an insight into how research findings can help inform policy making, and come away with a better understanding of how they can get involved. In this podcast we hear from three researchers who were part of the 2022 cohort - learning about their experience. Dr Fiona McLean from University of Dundee talks with Dr Dayne Beccano-Kelly from Cardiff University and Dr Sarah Marzi from Imperial College London, both group leaders within the UK Dementia Research Institute. For more information on the Royal Society Pairing Scheme visit: https://royalsociety.org/grants-schemes-awards/pairing-scheme/ You can find out more about our panellists, and their work on our website. There you will also find a full transcript: www.dementiaresearcher.nihr.ac.uk/podcast-…syndrome -- Like what you hear? Please review, like, and share our podcast - and don't forget to subscribe to ensure you never miss an episode. This podcast is brought to you in association with Alzheimer's Research UK and Alzheimer's Society, who we thank for their ongoing support.

Clíona Farrell narrates her blog written for Dementia Researcher. Down syndrome is caused by having a third copy of chromosome 21, and each year on the 21st of March (the 21st day of the third month) World Down syndrome Day is celebrated worldwide. People with Down syndrome are particularly susceptible to COVID-19, so this year the Down syndrome research community came together online. With participants from research studies, their families and friends, they discussed current research advances, offered advice from specialists and celebrated Down syndrome. Down syndrome is the most common genetic cause of Alzheimer's disease, however, few researchers study dementia in this context. Here, Clíona highlights her research in this field and explains the importance of the inclusion of people with Down syndrome in Alzheimer's research. Find the original text, and narration here on our website. https://www.dementiaresearcher.nihr.ac.uk/guest-blog-dementia-in-down-syndrome-and-the-role-of-neuroinflammation/ -- Clíona Farrell is a PhD Student in the UK Dementia Research Institute at University College London. Her work focuses on understanding neuroinflammation in Down syndrome, both prior to, and in response to, Alzheimer's disease pathology. Originally from Dublin, Ireland, Clíona completed her undergraduate degree in Neuroscience in Trinity College, and then worked as a research assistant in the Royal College of Surgeons studying ALS and Parkinson's disease. She also knows the secret behind scopping the perfect 99 ice-cream cone.. -- Enjoy listening? We're always looking for new bloggers, drop us a line. http://www.dementiaresearcher.nihr.ac.uk This podcast is brought to you in association with Alzheimer's Research UK and Alzheimer's Society, who we thank for their ongoing support. Enjoy listening? We're always looking for new bloggers, drop us a line dementiaresearcher@ucl.ac.uk  

This week Dr Fiona McLean from University of Dundee is with three colleagues all at the cutting edges of their fields to discuss their research, and the science behind vascular brain health, and what brain cells you'd really enjoy hanging out with on a night out in Glasgow! List to find out more… Maintaining a healthy brain is essential to having a healthy and long life. Brain health is increasingly talked about, but what does that really mean, and how does the vascular system play a role in that? Well, did you know that the health of your brain and your heart are connected? By keeping your heart and vascular system healthy, you also lower your risk for brain problems such as stroke and dementia… controlling blood pressure, eating health foods, and limiting alcohol, managing your risk of diabetes, not smoking and staying active and rested are important… this week our guests explore the science so don't worry if you don't know your extravascular cells from your endothelial cells, our great guests will explain (and if you do know, then you need to listen to discover our guests favourite cells, and which cells are which on a night out). This week's guests are: Dr Josie Fullerton, Postdoctoral Researcher at University of Glasgow studying extracellular vesicles, hypertension, stroke, heart & vascular disease & neuropathology. Dr Gaia Brezzo, Research Fellow in Cerebral Vascular Disease and Dementia at the UK Dementia Research Institute at The University of Edinburgh. Dr Sophie Quick, Post-doctoral researcher in the Centre for Regenerative Medicine, The University of Edinburgh researching neuroscience, specifically Cerebral Small Vessel Disease. -- You can find out more about our panellists, and their work on our website. There you will also find a full transcript: https://www.dementiaresearcher.nihr.ac.uk/podcast-vascular-brain-health-science/ -- Like what you hear? Please review, like, and share our podcast - and don't forget to subscribe to ensure you never miss an episode. This podcast is brought to you in association with Alzheimer's Research UK and Alzheimer's Society, who we thank for their ongoing support.

The largest genetic study of Alzheimer's to date has uncovered 42 more genes linked to the development of the disease. The new evidence has been hailed as crucial pieces to the puzzle to how the disease disrupts the brain's immune system, and can help in early detection. Around 70,000 New Zealanders suffer from dementia - with Alzheimer's the most common form. More than 700,000 people from around the world, including in New Zealand, had their genomes analysed in this study, which spanned across three decades. UK Dementia Research Institute spokesperson Dr Rebecca Sims was a co-lead of the study. She spoke to Corin Dann.

In recent years there has been an explosion of digital tools and platforms in the life sciences industry, designed to improve processes ranging from drug discovery and development, through to registration and commercialization.As with everything in pharma and biotech, the value of these tools hinges on the strength of the underlying data, making it essential to capture research in a robust and reliable way.One UK-based company, Labstep, is helping researchers to accomplish this with a fully automated, cloud-based digital data capture tool.While digital tools to assist medical research already exist, Labstep says that many scientists still resort to documenting experiments with pen and paper, an approach which it believes could be costing the industry billions in lost opportunities.Founded in 2016, the startup is already working with over 40 global scientific and health organisations, including GlaxoSmithKline (LSE: GSK) and the UK Dementia Research Institute, as well as The Francis Crick Institute.The company has raised around $3 million to date and is looking to exceed this amount with a fresh funding round, planned for the near future.In Episode 13 of The Pharma Letter Podcast, we discuss Labstep's technology and future ambitions with the company's chief executive, Jake Schofield.

A special podcast recorded during last weeks AD/PD™ 2022, Alzheimer's & Parkinson's Diseases Conference in Barcelona (isn't it great to be back meeting face to face). Katy Hole, PhD Student from University of Bath guest hosts talking with four early researchers sharing their reflections on the week, and conference and science highlights. Guests are: Dr Amanda Heslegrave, Senior Research Fellow in the UK Dementia Research Institute at University College London. Dr Percy Griffin, Director of Scientific Engagement at Alzheimer's Association Wagner Brum, MD-PhD student from University of Gothenburg Anna Wernick, PhD Student at University College London _________________________ You can find out more about our panellists, and their work on our website. There you will also find a full transcript: https://www.dementiaresearcher.nihr.ac.uk/podcast-adpd-conference-highlights-2022 _________________________ Like what you hear? Please review, like, and share our podcast - and don't forget to subscribe to ensure you never miss an episode. This podcast is brought to you in association with Alzheimer's Research UK and Alzheimer's Society, who we thank for their ongoing support.

Last week we attended the Alzheimer's Research UK Conference in Brighton. We took time out from the programme to talk with early career dementia researchers to ask them about their work, the challenges they have faced and how they overcame them, and to share a highlight from the conference. In this short interview we talk with Dr Soraya Meftah, Postdoctoral Research Fellow at the UK Dementia Research Institute, The University of Edinburgh. Soraya works in Neurophysiology of dementia (synaptic, neuronal, network dysfunction). Find out more about Soraya and her work on our website: https://www.dementiaresearcher.nihr.ac.uk/profile-dr-soraya-meftah-the-university-of-edinburgh/ If you would like to join us and add your profile and short interview to our researchers profile, drop us a line to dementiaresearcher@nihr.ac.uk 

In this podcast Dr Mike Daniels, Postdoctoral Research Fellow in the UK Dementia Research Institute at The University of Edinburgh guests hosts a discussion with three researchers who know a great deal about Neurons – they discuss their research, lab life and mice challenges, the amyloid hypothesis, and the reproducibility. The healthy human brain contains tens of billions of neurons—specialized cells that process and transmit information via electrical and chemical signals. They send messages between different parts of the brain, and from the brain to the muscles and organs of the body. Alzheimer's disease disrupts this communication among neurons, resulting in loss of function and cell death. This weeks guests are: Dr Soraya Meftah, Postdoctoral Research Fellow in the UK Dementia Research Institute at The University of Edinburgh. Sorya explores the Neurophysiology of dementia (synaptic, neuronal, network dysfunction). Tabitha Broadbelt, PhD Student at The University of Edinburgh. Tabitha works in the field of Behavioural Neuroscience, Learning and Memory. Specifically looking at mechanisms of learning modulation in a mouse model of amyloid pathology. Jack Bray, PhD Student at University of Aberdeen. Jack is investigating EEG and behavioural abnormalities in preclinical mouse models of dementia (he also knows how to drive a ferry). You can find out more about our guests, and access a full transcript of this podcast on our website at: https://www.dementiaresearcher.nihr.ac.uk/podcast Register on our website to receive your weekly bulletin, and to access more great content – blogs, science, career support + much more https://www.dementiaresearcher.nihr.ac.uk This podcast is brought to you in association with Alzheimer's Research UK and Alzheimer's Society, who we thank for their ongoing support.

Postdoc Scientist at the UK Dementia Research Institute at The University of Edinburgh, Dr Mike Daniels presents what he learned from attending the Alzheimer's Research UK grant review board. Sharing tips on why grants get funded and why they don't. --Hosted by Dr Fiona McLean and recorded live in front of an audience at the ARUK Scotland Network Meeting on the 3rd December 2021. --You can find out more about our guests, and access a full transcript of this podcast on our website at: https://www.dementiaresearcher.nihr.ac.uk/podcast --Register on our website to receive your weekly bulletin, and to access more great content – blogs, science, career support + much. --Dementia Researcher is brought to you by University College London, Queen Square Biomedical Research Centre, and is funded by the National Institute for Health Research, Alzheimer's Research UK and Alzheimer's Society.

Adam Smith & Dr Kamar Ameen-Ali host this Twitter Spaces discussion for Dementia Researcher. They speak with four dementia research Professors about their careers, how they navigated the path to professor, discovering what they learned along the way, what they might do differently and getting their advice for any postdocs who are looking to progress, decide what comes next or who just feel stuck in the endless cycle of short-term contracts. Our guest panellists are: Tara Spires-Jones - Professor of Neurodegeneration & Deputy Director, Centre for Discovery Brain Sciences within the UK Dementia Research Institute at The University of Edinburgh. Sci-fi fan and working on the Neurobiology of synapse degeneration. Louise Serpell - Professor of Biochemistry & Director of Sussex Neuroscience at the University of Sussex. Leading a busy research group with four Postdocs and three PhD students. Researching proteins and how they fold and misfold and proving her physics teacher wrong every day! Professor Claire Surr - Director of the Centre for Dementia Research at Leeds Beckett University, cycling and researching Dementia care and services with particular interest in care homes and hospital care and workforce education and training. Tammaryn Lashley - Professor of Neuroscience and Director of Research for the Queen Square Brain Bank at University College London. UCL 18 year veteran, leading a Neuropathology lab, supervising 11 PhD Students and wrangling two children. If you would like to get involved and join us for our next social audio chat drop us a line at https://www.dementiaresearcher.nihr.ac.uk and follow us on Twitter at https://www.twitter.com/dem_researcher ________________________ Odd News by Twin Musicom is licensed under a Creative Commons Attribution 4.0 licence. https://creativecommons.org/licenses/by/4.0/ Artist: http://www.twinmusicom.org/

It's World Alzheimer's Day - a day when we discuss the disease, work to raise awareness and call for action. Today's podcast is a special edition to announce a very important action from Race Against Dementia (RAD) supported by Alzheimer's Research UK, the appointment of four new Research Fellows. In the show we talk to new Chief Executive Bridget Barker, who introduces their newly appointed Fellows. They share their research plans, what they're most looking forward to about the programme and provide a few top tips for those applying for similar positions. Meet the new RAD Fellows: Dr Maura Malpetti, from University of Cambridge. Maura uses multimodal imaging techniques (multi-tracer PET and MRI) integrated with fluid markers, post-mortem validation, and prognostic modelling approaches in frontotemporal lobar degeneration. Dr Aitana Sogorb Esteve, from the UK Dementia Research Institute at University College London. Maura is looking for fluid biomarkers of synaptic dysfunction in genetic FTD and aiming to develop a technique for measuring these synaptic markers in blood. Dr Emily Hill, from University of Warwick. Emily uses detailed electrophysiological approaches to understand the mechanisms underlying tau pathology in neurodegeneration. This work aims to highlight new targets for the treatment of tauopathies like Alzheimer's disease. Dr Wioleta Zelek, from Cardiff University. Wioleta is an Immunologist focussing on the complement system, its biology, roles in disease and in manipulating the system for therapy. Of particular interest is in the terminal pathway of the complement system that generates the highly pro-inflammatory molecules C5a and the membrane attack complex (MAC). The RAD Fellowship has been discussed on the show before, it is unique in providing five years of funding, with research costs, only open to people who have completed their PhD within the past three years, and provided with a whole programme of additional support – from performance coaching, mentoring through to connections to cutting edge industries and Formula One Teams. The charity started Formula One legend Sir Jackie Steward, aims to instil Formula One attitude into scientific research, to accelerating pace discovery, and with these latest appointments they now fund 10 Fellows based in the UK, USA and Australia. In the UK the programme is supported by Alzheimer's Research UK, and the James Dyson Foundation. Find out more about RAD and its Fellows, and how you could provide your own support for their work: https://www.raceagainstdementia.com/ You can find out more about our guests, and access a full transcript of this podcast on our website at: https://www.dementiaresearcher.nihr.ac.uk/podcast This podcast also sits on YouTube with English Language Subtitles. _________________________ Finally, please review, like, and share our podcast - and don't forget to subscribe to ensure you never miss an episode. Register on our website to receive your weekly bulletin, and to access more great content – blogs, science, career support + much more https://www.dementiaresearcher.nihr.ac.uk This podcast is brought to you in association with Alzheimer's Research UK and Alzheimer's Society, who we thank for their ongoing support. ______________ Complete the UCL ISTAART #ECRPIA Survey at https://www.dementiaresearcher.nihr.ac.uk/survey

In today's podcast Professor Selina Wray from University College London, meets four early career researchers, who know a great deal about the brain, human iPSC derived cells and the ubiquitin-proteasome pathway (not that isn't a new type of electric car). We'll be discussing their research, discovering more about super resolution microscopy, and how they're researching the ubiquitin proteasome system, and its connection to dementia. We're delighted to welcome our guests: PhD Students Liina Sirvio, Katiuska Daniela Pulgar Prieto from the UK Dementia Research Institute at Imperial College London. Georgie Lines, PhD Student from University College London and Dr Emma Mee Haynes a Postdoctoral Research Associate also from the UK Dementia Research Institute at Imperial College London. What is the purpose of ubiquitin proteasome system? In eukaryotic cells, proteasomes perform crucial roles in many cellular pathways by degrading proteins to enforce quality control and regulate many cellular processes such as cell cycle progression, signal transduction, cell death, immune responses, metabolism, protein-quality control, and development. You can find out more about our guests, and access a full transcript of this podcast on our website at: https://www.dementiaresearcher.nihr.ac.uk/podcast _________________________ Finally, please review, like, and share our podcast - and don't forget to subscribe to ensure you never miss an episode. Register on our website to receive your weekly bulletin, and to access more great content – blogs, science, career support + much more https://www.dementiaresearcher.nihr.ac.uk This podcast is brought to you in association with Alzheimer's Research UK and Alzheimer's Society, who we thank for their ongoing support.

Whilst everyone may experience dementia and its symptoms differently, the pathway to diagnosis is very similar for most people, but could all that be about to change? This week Adam Smith, speaks to a Psychiatrist, a Neurologist and a Scientist. They discuss the current diagnosis pathway, the tests involved, and how that could change as with the development of blood based biomarkers. Exploring the science behind the new tests, their development, and how these new tests could be used in frontline services to improve accuracy, support clinical trials and to improve care – and is the NHS ready? This week's guests are: Dr Elizabeth Coulthard, Consultant Neurologist and Associate Professor at University of Bristol and North Bristol NHS Trust. Dr Josie Jenkinson, Consultant Psychiatrist for Older People and Clinical Academic at Surrey and Borders Partnership NHS Trust. Dr Amanda Heslegrave, Senior Research Fellow focussed on Biomarkers in Neurodegeneration at the UK Dementia Research Institute at University College London. Emerging blood-based biomarkers for Alzheimer disease are an exciting new development. They could provide an accessible, easy to delivery and inexpensive screening tool. Looking to the future, when disease-modifying or prevention treatments will be available, investigators are focused on how to detect the earliest biological signals of Alzheimer disease, perhaps even years or decades before clinical symptoms appear – and that's when these tests could really become essential. However, how could they be used now? Could they improve accuracy of diagnosis? Replace the need for other more expensive tests? Ensure we no longer have to send people home, telling them they have Mild Cognitive Impairment? Reduce misdiagnosis? Patients and their families want to know, Is this Alzheimer disease, or something that can be reversed? Can we answer that question now? And Could this new biomarker help? All will be discussed in this weeks show. _________________________ You can find out more about our panellists, and their work on our website: https://www.dementiaresearcher.nihr.ac.uk A transcript of this podcast is also available here https://www.dementiaresearcher.nihr.ac.uk/podcast-diagnosing-dementia-now-and-in-the-future _________________________ Like what you hear? Please review, like, and share our podcast - and don't forget to subscribe to ensure you never miss an episode. This podcast is brought to you in association with Alzheimer's Research UK and Alzheimer's Society, who we thank for their ongoing support.

Dementia is mentioned a lot in the news, and is only going to become more relevant as we continue to live longer. But what separates it from old age? And how does Alzheimer's disease relate to it? In this episode we are joined by the brilliant Mike Daniels, a researcher in this fascinating field who works for the UK Dementia Research Institute. We'll tackle some headlines which have cropped up in the news recently that deal with reducing your risk of dementia and potential treatments. Have you heard?Drug that can reverse effects of ageing on the brain shows promise as treatment for Alzheimer’sBrain health: Eat your way to better cognitive health to reduce your risk of dementiaEarlier Diabetes Onset Could Raise Dementia RiskIf you want to know more about how lifestyle affects your risk of dementia, there is an excellent resource available here: Dementia Risk Factors and PreventionYou can find the Have You Heard Podcast on YouTube, iTunes, Spotify or your favourite podcasting app. We'd love you to send us any interesting news articles you've seen, questions you have, or feedback for us. Leave a comment below, send us an email at haveyouhearduk@gmail.com or use our contact form. You can also contact us on Twitter or Facebook.Music in this episode:"Funkorama"Kevin MacLeod (incompetech.com)Licensed under Creative Commons: By Attribution 3.0http://creativecommons.org/licenses/by/3.0/

As part of National Careers Week, 1st – 6th March, Dementia Researcher has teamed up with Alzheimer’s Society, Alzheimer’s Research UK, Race Against Dementia, Dementias Platform UK and the UK Dementia Research Institute to deliver the first Dementia Research Careers Festival. The week-long programme of events, aimed at undergraduates and young-people, will highlight the variety of ways they could bring their talents to dementia research (mostly UK based, but anyone from across the world can join us). From Scientists to Artists, Psychologists to Coders, Communicators to Healthcare Trainees – people from all levels of education and fields of study can find a future in dementia research. Live daily webinars will bring researchers together to discuss their own work and careers paths. New resources, blogs and articles are planned to provide support, advice and guidance, exploring how others came to be in dementia research. There will also be Q&A sessions and connections to over 25 Universities and employers running MSc information sessions + much more. Get involved Here are five ways you could help: 1. Create a showreel – Record a 30 second film clip, telling us your name, what you do and why dementia research is important. Share yourself on Instagram tagging dementia_researcher and #NCW2021 or email it to us adam.smith@nihr.ac.uk if you prefer, (use portrait mode, and email your clip). 2. Write something – We know many of you have your own blogs, podcasts and YouTube channels. Write or record something, share your story and inspire others, then email us with a link, so we can share. 3. Follow us everywhere and amplify our messages – Social media is powerful, we’re promoting the event on Twitter, Instagram, YouTube, Facebook and via our Podcast. Please follow-us and retweet, repost and like the things we’re sharing to promote the event. Also tell your colleagues, family and friends. 4. Download & display our Twitter Header – We know that undergraduates prefer Instagram and TikTok, but their parents might be on Twitter (feeling old?), while you’re there, it would be great if you could share the Tweet out advert. 5. If you are already a researcher, but would like to know more about dementia research, or a different field of study, you're also welcome to join one of our daily webinars - link below. Here are all the links you will need to help: https://linktr.ee/dementiaresearcher Thank you for your support. https://www.youtube.com/DementiaResearcher https://www.facebook.com/Dementia-Researcher-605722373417876/ https://twitter.com/dem_researcher https://www.instagram.com/dementia_researcher/

Dr Megan O’Hare interviews Professor Bart De Strooper and Professor David Llewellyn, discussing the new UK Dementia Research Institute and DEMON Network partnership to unlock the potential of Artificial Intelligence (AI). Professor Bart De Strooper is National Director and Group Leader at the UK Dementia Research Institute and Group Leader in his own research he looks at the cellular and molecular mechanisms underlying Alzheimer’s disease and other neurodegenerative disorders. Professor David Llewellyn is the DEMON Network Director and an Associate Professor at the University of Exeter Medical School and a Fellow at the Alan Turing Institute. His research aims to enhance the timely detection of dementia, with a focus on developing strategies for primary and secondary prevention using machine learning. The Deep Dementia Phenotyping (DEMON) Network brings together academics, clinicians and other partners from across the world, and now it has joined forced with the UK Dementia Research Institute. The aim of this new collaboration is to rapidly speed up the transformation of data into clinical and biologically relevant knowledge in neurodegeneration research, to strengthen links with clinical researchers and industry, and to drive forward experimental dementia research using data science and artificial intelligence. There is no universally agreed definition of AI. The term broadly refers to computing technologies that resemble processes associated with human intelligence, such as reasoning, learning and adaptation, sensory understanding, and interaction. An important feature of contemporary AI technologies is that they are increasingly able to make sense of varied and unstructured kinds of data – so what could happen when you combine AI with large amounts of health and societal data? The potential is amazing, and could be the key to unlocking improved dementia risk analysis, diagnosis and treatments. You can find out more about our panellists, and their work on our website www.dementiaresearcher.nihr.ac.uk. A transcript of this podcast is also available here https://www.dementiaresearcher.nihr.ac.uk/podcast-gate-and-dementia Like what you hear? Please review, like, and share our podcast - and don't forget to subscribe to ensure you never miss an episode. _____________________________________________________________________ For more information on the collaboration visit: https://ukdri.ac.uk/news-and-events/new-partnership-with-the-demon-network-will-drive-forward-experimental-dementia-research To join the DEMON Network visit: http://demondementia.com/ _____________________________________________________________________ This podcast is brought to you in association with Alzheimer's Research UK and Alzheimer's Society, who we thank for their ongoing support.

This episode features Catie’s interview with Asma, a Postdoctoral Fellow at the UK Dementia Research Institute who studies the Blood Brain Barrier (BBB).

Dr Megan O'Hare is joined by three researchers based at the UK Dementia Research Institute in Cardiff - Dr Sarah Carpanini, Dr Tom Phillips and Dr Megan Torvell to discuss neuroinflammation in neurodegeneration this time using mouse models to examine underlying pathophysiology during brain development and beyond. Join them to hear about physiological synapse loss that occurs during normal, healthy development of the brain contrasting to pathological synapse loss that occurs in disease states such as Alzheimer's Disease. Hear more about the role of microglia and the role of the complement cascade as well as the virtues of using mouse models in general for studying an ageing disease. You can find out more about our panellists, and their work on our website www.dementiaresearcher.nihr.ac.uk. A transcript of this podcast is also available here https://www.dementiaresearcher.nihr.ac.uk/podcast-neuroinflammation-in-mouse-models/ Like what you hear? Please review, like, and share our podcast - and don't forget to subscribe to ensure you never miss an episode. Regular host Adam Smith is hosting a 12 hour Dementia Research Live Chatathon - 7th September, 12 hours, over 55 researchers to raise much needed funding for Alzheimer's Research UK. To find out more visit http://www.chatathon.uk This podcast is brought to you in association with Alzheimer's Research UK and Alzheimer's Society, who we thank for their ongoing support.

A simple blood test to diagnose Alzheimer's disease -- on the wish list of many doctors, researchers and patients -- may be closer to becoming a reality, according to the results of studies presented virtually this week during the Alzheimer's Association International Conference 2020.In a study presented Tuesday at the conference and published in JAMA, a blood test to detect the tau protein, one of the hallmark signs of Alzheimer's, was as accurate as a spinal tap or a positron emission tomography (PET) scan, which are the current gold standards of diagnosis while a person is living.The test could also differentiate between different types of cognitive dementia and even flag early signs of Alzheimer's. While more research is required and such a test is likely still years away from being available, experts say the results are encouraging."This research represents an exciting step towards developing a blood test that could help identify Alzheimer's disease by focusing on specific sub-types of tau, one of the key proteins that becomes abnormal as part of the Alzheimer's disease changes in the brain," said Clive Ballard, professor of age-related disease at the University of Exeter Medical School, in the UK, who was not involved in the study."A reliable blood test for Alzheimer's disease would be a huge boost for dementia research, allowing scientists to test treatments at a much earlier stage which in turn could lead to a breakthrough for those living with dementia," said Dr. Rosa Sancho, head of research at Alzheimer's Research UK, who was also not involved in the study.Looking for a mutant proteinIn a three-part study, researchers from the United States and Sweden measured an abnormal version of the tau protein called p-tau217 and found more of that modified tau in the blood of people with Alzheimer's disease than in healthy participants.How does tau get into blood? It appears to cross the blood-brain barrier."Tau protein is modified and clumps abnormally in the brains of people with Alzheimer's disease and some frontotemporal dementias, and some of this tau protein leaks out of the brain into the blood," said Tara Spires-Jones, the deputy director of the Centre for Discovery Brain Sciences at the University of Edinburgh, who was not involved in the study.The researchers report the blood test can distinguish Alzheimer's disease from other types of dementia and Parkinson's with a high degree of accuracy -- 89% to 98%.Additionally, measuring p-tau217 levels may also be able to detect brain changes 20 years before dementia symptoms occur."This test, once verified and confirmed, opens the possibility of early diagnosis of Alzheimer's before the dementia stage, which is very important for clinical trials evaluating novel therapies that might stop or slow down the disease process," the researchers, led by Dr. Oskar Hansson from Lund University in Sweden, wrote.Another study, published Tuesday in the Journal of Experimental Medicine, also verified that p-tau217 was more closely related to amyloid buildup in the brain than other chemicals that have been investigated."These two papers add to increasing evidence that modified tau proteins in the blood can accurately reflect Alzheimer's disease in processes occurring in the brain," said Amanda Heslegrave, a senior research fellow at the UK Dementia Research Institute at University College London, who was not involved in the study.In your doctor's officeThe formation of brain proteins, amyloid and tau, into clumps of amyloid plaques and tau tangles are defining physical features of Alzheimer's disease, but they are hard to detect without expensive PET scans or invasive spinal taps, neither of which is routinely covered by insurance.Doctors are left with verbal and written tests of memory and cognitive impairment, combined with interviews with patients' family members and caregivers about their behavior. That approach makes it tough to accurately diagnosis Alzheimer's...

This week we are recording a daily podcast, sharing all the news and highlights from this year’s Alzheimer's Association International ‘Virtual’ Conference. Day Three “Clinical Manifestations; Drug Development” – Adam Smith is joined by Dr Anna Volmer, Speech & Language Therapist and academic at University College London, Danielle Wilson, Commercialisation Lead at the UK Dementia Research Institute at Imperial College London and Dr Leonidas Chouliaras, Psychiatrist and NIHR Clinical Lecturer at University of Cambridge and Cambridgeshire and Peterborough NHS Foundation Trust.. Check back at this time tomorrow for news from day four, and checkout the twitter feed with #AAIC20 to find more. All the content from the AAIC Conference will be available for free for 30 days after the conference (60 days for ISTAART Members), register now at https://www.alz.org/aaic/overview.asp ______________________________________________ This podcast series is brought to you by Dementia Researcher. You can find out more about our panellists, and their work on our website www.dementiaresearcher.nihr.ac.uk. A transcript of this podcast is also available here https://www.dementiaresearcher.nihr.ac.uk/podcasts ______________________________________________ You can now find our podcasts on your preferred smart home speaker – just ask it for the “Dementia Researcher Podcast” This podcast is brought to you in association with Alzheimer's Research UK and Alzheimer's Society, who we thank for their ongoing support.

This week we are recording a daily podcast, sharing all the news and highlights from this year’s Alzheimer's Association International ‘Virtual’ Conference. Day One “Basic Science and Pathogenesis” – Dr Megan O’Hare is joined by Professor Louise Serpell, from the University of Sussex, Dr Emily Maguire from the UK Dementia Research Institute at Cardiff University and Dr Lindsay Sinclair from University of Bristol. Check back at this time tomorrow for news from day two, and checkout the twitter feed with #AAIC20 to find more. ______________________________________________ This podcast series is brought to you by Dementia Researcher. You can find out more about our panellists, and their work on our website www.dementiaresearcher.nihr.ac.uk. A transcript of this podcast is also available here https://www.dementiaresearcher.nihr.ac.uk/podcasts ______________________________________________ You can now find our podcasts on your preferred smart home speaker – just ask it for the “Dementia Researcher Podcast” This podcast is brought to you in association with Alzheimer's Research UK and Alzheimer's Society, who we thank for their ongoing support.

En este capítulo, Ángel Serrano Zurita conecta en 'La hora del café' con Blanca Diaz-Castro, una doctora en neurociencia sevillana que está liderando un equipo de investigación en Edimburgo en el UK Dementia Research Institute. Se encargan de estudiar los astrocitos, unas células del cerebro conectadas a las neuronas y a los vasos sanguíneos cerebrales, a la vez, profundizando en la comprensión de los mecanismos moleculares y celulares que vinculan la disfunción vascular cerebral y la demencia con la esperanza de que sus resultados "se traduzcan en el desarrollo de métodos y tratamientos de diagnóstico temprano". Ambos comparten mesa de café virtual y una buena taza de té negro, ya que prefiere no tomar café por que le "pone muy nerviosa", revela. Durante la conversación, la spaniard da cuenta de cuáles son los atractivos de los sitios donde ha vivido (Chicago, Los Ángeles y Edimburgo), qué cosas son las que más echa de menos de España e, incluso, cuál es esa canción que le recuerda a su pasado en su tierra. Además, una semana más, Raquel Carneros, profesora de inglés certificada por Cambridge Assessment English y capitana de la sección 'Spaniard's Lessons' de Planeta Spaniard nos trae una nueva clase de inglés para españoles. En ésta, resuelve dudas de los oyentes acerca del inglés. En este capítulo, la teacher da la solución a las preguntas de tres oyentes: Heber (México), Jon (México) y Mayra (Bolivia). Preguntan acerca de la pronunciación de "live" como adjetivo y como verbo y las diferencias de uso entre "in" y "at" (ej: "in university" o "at university") y entre "although" y "though" (incluye explicación sobre la corrección o incorrección al usar "even" delante de cada una de ellas). Puedes enviarle tus dudas para las siguientes sesiones de estas clases de inglés para españoles de Planeta Spaniard, para sus 'Spaniard's Lessons' a través de su Instagram. Las resolverá en directo en nuestra radio el próximo jueves. Síguenos en nuestra web Síguenos en Facebook Síguenos en Instagram Suscríbete a nuestro canal de IVOOX Suscríbete a nuestro canal de Youtube Instagram de nuestra teacher --- This episode is sponsored by · Anchor: The easiest way to make a podcast. https://anchor.fm/app Support this podcast: https://anchor.fm/planetaspaniard/support

Colin Mahoney, JNNP Podcast editor, is joined by Dr Jonathan Rohrer, MRC Clinician Scientist, Dementia Research Centre, UCL Institute of Neurology. Carolin Heller, Dementia Research Centre and UK Dementia Research Institute. to discuss how increased levels of GFAP may be used to detect advancing neurodegeneration and clinical change in those with Progranulin associated Frontotemporal Dementia. https://jnnp.bmj.com/content/91/3/263

This week we are recording a daily podcast, sharing all the news and highlights from this years Alzheimer's Association International Conference in Los Angeles. Day Four (Final Day) - Adam Smith is joined by Dr James Pickett from Alzheimer's Society, Dr Claire Lancaster from the University of Oxford and Dr Emily Maguire from the UK Dementia Research Institute at Cardiff University. Thank you to everyone who has contributed to these podcasts and for listening. We hope they have been useful and interesting. The AAIC is a great event for Early Career Researchers, so we hope to see you there next year in Amsterdam. To get more news on the conference, visit their twitter feed with #AAIC19.

This weeks podcast was recorded a few weeks ago at the Alzheimer's Research UK Conference in Harrogate. Dr Katie Stubbs speaks with Dr Katie Askew, Dr Mike Daniels and PhD student Makis Tzioras. This team are all based at the UK Dementia Research Institute at the University of Edinburgh. Our special subject for this week is Microglia. For those listeners who don’t know, Microglia form part of the brain’s immune system and are key players in controlling brain health via multiple mechanisms. These mechanisms include releasing cytokines, phagocytosis of debris, synaptic pruning and forming the glio-vascular unit. In neurodegenerative diseases, like dementia, nearly all physiological microglial functions stray away from homeostasis and contribute to disease pathogenesis. So you can see why research in this field is important, and why it’s been such a hot topic at dementia research conferences this year. In the build up to celebrating 10,000 plays, we are asking listeners to complete our short survey to be in with a chance to win a great pair of high-end Sony Headphones. To find out more visit: https://www.dementiaresearcher.nihr.ac.uk/10000plays/ Please remember to like, subscribe and review our podcast.

In this episode, Vinoy talks to Dr.Tara Spires-Jones, professor at the University of Edinburgh and the UK Dementia Research Institute.

In this latest edition of NCTalks, Lauren Pulling (Editor) chats with Tara Spires-Jones, a Professor of Neurodegeneration at the University of Edinburgh (UK). Tara is Deputy Director of the Centre for Discovery Brain Sciences and Program Lead at the Edinburgh center of the UK Dementia Research Institute. Tara is also Chair of the Alzheimer’s Research UK (ARUK) Grant Review Board, and is active is science communications and outreach – making her a very busy person! In this podcast recorded at the ARUK Conference in London (21–22 March 2018), Tara shares her recent research into the roles of ApoE4 and clusterin in synapse degeneration in Alzheimer’s disease and the viability of synapse degeneration as a treatment target. Tara also discusses animal models of neurodegeneration, the impact of cuts to neuroscience funding, and the importance of mentorship in science. View more podcasts, news and exclusive interviews at www.neuro-central.com

De wereldberoemde alzheimerexpert Bart de Strooper geeft leiding aan het UK Dementia Research Institute in Londen. Hij is ervan overtuigd dat we ooit een middel tegen Alzheimer vinden, maar daar zijn veel mensen en heel veel geld voor nodig. Hij is te gast.

Two key themes to come out of the Alzheimer’s Research UK (ARUK) Conference (Aberdeen, UK, 14–15 March 2017) were the celebration of world-class research, and hope for the future of dementia understanding, prevention and treatment, particularly with the forging and strengthening of new partnerships, collaborations and initiatives. In May 2016, ARUK committed £50 million to support the MRC-led UK Dementia Research Institute (DRI), a new hub of dementia research based at University College London (UK), with additional centers across the UK to be announced imminently. Following an international search, Bart De Strooper was recently announced as the Director of the Institute. We caught up with Prof De Strooper at the ARUK Conference to find out more about the DRI and his visions for this exciting new venture for dementia research. You can find more podcasts, interviews and news at www.neurology-central.com

In this episode Alzheimer’s Society Ambassador Keith Oliver describes how his world changed when he was diagnosed with early-onset Alzheimer’s disease at the age of 55. He shares his hopes for the new MRC-led UK Dementia Research Institute which has received £50m backing from both the Alzheimer’s Society and Alzheimer’s UK. Paracetamol is usually safe and effective, but overdose can damage the liver and in 2014 was attributed to 200 deaths in the UK. Hear how MRC scientists are testing a new treatment using liver cells grown from stem cells. We visit the MRC Weatherall Insitute for Molecular Medicine in Oxford to find out how single cell technology is changing our understanding of biology. And we ask fellows at the annual MRC Fellows symposium for tips on preparing grant applications, and dealing with rejection. Read more about all topics on our blog insight.mrc.ac.uk and in our quarterly magazine www.mrc.ac.uk/network Thanks to contributors Keith Oliver, David Hay, Claus Nerlov, Adam Mead, Roy Drissen, Stefan Marciniak, Luke Munford, Lavinia Paternoster, Chris Toseland, Hayriye Cagnan and Emanuelle Giorgi. MRC talks is presented by Isabel Baker and produced by Hasina Sacranie. Music credits: "Clean Soul" Kevin MacLeod Licensed under Creative Commons: By Attribution 3.0 "Brittle Rille" Kevin MacLeod Licensed under Creative Commons: By Attribution 3.0