Podcasts about uk dementia research institute

Dr Clíona Farrell, narrating her blog written for the Dementia Researcher website. After finishing her PhD and a short postdoc extension, Clíona took a five month career break to travel across Asia before starting a new postdoctoral role at UCL. In this blog, she reflects on the emotional and practical challenges of stepping away from academia, the privilege and uncertainty of taking time out, and what it feels like to return refreshed to a new lab, new techniques, and a genuine fresh start. Find the original text, and narration here on our website. https://www.dementiaresearcher.nihr.ac.uk/blog-returning-to-work-after-a-travel-filled-career-break/ -- Dr Clíona Farrell is a Postdoctoral Researcher in the UK Dementia Research Institute at University College London. Her work focuses on understanding neuroinflammation in Down syndrome, both prior to, and in response to, Alzheimer's disease pathology. Originally from Dublin, Ireland, Clíona completed her undergraduate degree in Neuroscience in Trinity College, and then worked as a research assistant in the Royal College of Surgeons studying ALS and Parkinson's disease. She also knows the secret behind scopping the perfect 99 ice-cream cone. @ClionaFarrell_ -- Enjoy listening? We're always looking for new bloggers, drop us a line. http://www.dementiaresearcher.nihr.ac.uk This podcast is brought to you in association with Alzheimer's Association, Alzheimer's Research UK, Alzheimer's Society and Race Against Dementia, who we thank for their ongoing support. -- Follow us on Social Media: https://www.instagram.com/dementia_researcher/ https://www.facebook.com/Dementia.Researcher/ https://twitter.com/demrescommunity https://www.linkedin.com/company/dementia-researcher https://bsky.app/profile/dementiaresearcher.bsky.social Join our community: https://onelink.to/dementiaresearcher

In this episode of the Dementia Researcher podcast, host Adam Smith chats with with Professor Paul Freemont and researcher Tom Adam from the UK Dementia Research Institute at Imperial College London to discuss the critical issue of urinary tract infections (UTIs) in individuals living with dementia. The conversation highlights the complexities of diagnosing UTIs in people living with dementia, where communication barriers and atypical presentations often lead to misdiagnosis and unnecessary hospitalisations. The guests emphasise the urgent need for improved detection methods, as UTIs can exacerbate cognitive decline and lead to severe health complications. They talk about their work to develop and introduce an innovative novel point-of-care diagnostic device designed specifically for dementia patients, which aims to facilitate early detection of UTIs in a home and care home setting, thereby reducing the reliance on traditional symptom reporting and hospital visits. Key takeaways:

Dr Clíona Farrell, narrating her blog written for the Dementia Researcher website. In this World Alzheimer's Day blog, Dr Clíona Farrell shares her reflections while on a career break from postdoctoral research. She considers both the progress and persistent challenges in the field of Alzheimer's research, from genetic and lifestyle risk factors to the development of new treatments and biomarkers. While funding pressures and lack of diversity remain barriers, recent breakthroughs in therapies and diagnostics bring optimism. Her reflection highlights the importance of continued research, collaboration, and inclusivity in shaping a future where effective treatments and earlier diagnoses are within reach. Find the original text, and narration here on our website. https://www.dementiaresearcher.nihr.ac.uk/blog-world-alzheimers-day-reflection/ -- Dr Clíona Farrell is a Postdoctoral Researcher in the UK Dementia Research Institute at University College London. Her work focuses on understanding neuroinflammation in Down syndrome, both prior to, and in response to, Alzheimer's disease pathology. Originally from Dublin, Ireland, Clíona completed her undergraduate degree in Neuroscience in Trinity College, and then worked as a research assistant in the Royal College of Surgeons studying ALS and Parkinson's disease. She also knows the secret behind scopping the perfect 99 ice-cream cone. @ClionaFarrell_ -- Enjoy listening? We're always looking for new bloggers, drop us a line. http://www.dementiaresearcher.nihr.ac.uk This podcast is brought to you in association with Alzheimer's Association, Alzheimer's Research UK, Alzheimer's Society and Race Against Dementia, who we thank for their ongoing support. -- Follow us on Social Media: https://www.instagram.com/dementia_researcher/ https://www.facebook.com/Dementia.Researcher/ https://twitter.com/demrescommunity https://www.linkedin.com/company/dementia-researcher https://bsky.app/profile/dementiaresearcher.bsky.social Join our community: https://onelink.to/dementiaresearcher

Dr Clíona Farrell, narrating her blog written for the Dementia Researcher website. Genetically determined Alzheimer's disease, though rare, offers key insights into dementia research. In this blog, Dr Clíona Farrell recaps highlights from the ADAD-DSAD conference in Barcelona. Covering autosomal dominant Alzheimer's disease and Down syndrome-related Alzheimer's, she explores genetics, APOE's role in symptom onset, clinical trial progress for anti-amyloid therapies in people with Down syndrome, and the vital importance of lived experience and PPIE in shaping research. Find the original text, and narration here on our website. https://www.dementiaresearcher.nihr.ac.uk/blog-genetically-determined-alzheimers-adad-dsad-recap/ -- Dr Clíona Farrell is a Postdoctoral Researcher in the UK Dementia Research Institute at University College London. Her work focuses on understanding neuroinflammation in Down syndrome, both prior to, and in response to, Alzheimer's disease pathology. Originally from Dublin, Ireland, Clíona completed her undergraduate degree in Neuroscience in Trinity College, and then worked as a research assistant in the Royal College of Surgeons studying ALS and Parkinson's disease. She also knows the secret behind scopping the perfect 99 ice-cream cone. @ClionaFarrell_ -- Enjoy listening? We're always looking for new bloggers, drop us a line. http://www.dementiaresearcher.nihr.ac.uk This podcast is brought to you in association with Alzheimer's Association, Alzheimer's Research UK, Alzheimer's Society and Race Against Dementia, who we thank for their ongoing support. -- Follow us on Social Media: https://www.instagram.com/dementia_researcher/ https://www.facebook.com/Dementia.Researcher/ https://twitter.com/demrescommunity https://www.linkedin.com/company/dementia-researcher https://bsky.app/profile/dementiaresearcher.bsky.social Join our community: https://onelink.to/dementiaresearcher

Dementia is now the UK's leading cause of death - but could a vaccine one day help prevent it? New data from Wales suggests the shingles vaccine is linked to a 20% lower risk of developing dementia in later life, adding to evidence that viral infections can influence brain health.Dr. Pascal Geldsetzer, Assistant Prof of Medicine at Stanford University discusses his findings and the further evidence required to prove this link, along with Prof Tara Spires-Jones, Group Leader in the UK Dementia Research Institute.The UK has begun using the world's first gonorrhoea vaccine - though it was originally developed for meningitis. With antibiotic-resistant strains increasing, we speak to Dr Suneeta Soni about why gonorrhoea has been so hard to target with vaccines.At the Bristol Robotics Lab, engineers are creating devices to support mobility in older age. James meets Jonathan Rossner and tries out “The Right Trousers” - an inflatable exoskeleton designed to help people walk and to strengthen their muscles.Presenter: James Gallagher Producers: Debbie Kilbride, Tom Bonnett & Minnie Harrop Editor: Ilan Goodman Production coordinator: Ishmael Soriano This episode was produced in partnership with The Open University.

Dr Clíona Farrell, narrating her blog written for the Dementia Researcher website. In this blog, Clíona shares reflections from the Hot Brain 3 conference, which examined the intersection of climate change and brain health. From the exacerbation of neurological conditions like Dravet syndrome and dementia during heatwaves, to emerging links between rising temperatures and preterm births, the event laid bare the growing risks posed by a warming planet. With first-hand accounts, scientific findings, and health system responses, the blog highlights the urgent need for more research and action in both clinical and policy spaces. Find the original text, and narration here on our website. https://www.dementiaresearcher.nihr.ac.uk/blog-climate-change-and-the-brain/ -- Dr Clíona Farrell is a Postdoctoral Researcher in the UK Dementia Research Institute at University College London. Her work focuses on understanding neuroinflammation in Down syndrome, both prior to, and in response to, Alzheimer's disease pathology. Originally from Dublin, Ireland, Clíona completed her undergraduate degree in Neuroscience in Trinity College, and then worked as a research assistant in the Royal College of Surgeons studying ALS and Parkinson's disease. She also knows the secret behind scopping the perfect 99 ice-cream cone. @ClionaFarrell_ -- Enjoy listening? We're always looking for new bloggers, drop us a line. http://www.dementiaresearcher.nihr.ac.uk This podcast is brought to you in association with Alzheimer's Association, Alzheimer's Research UK, Alzheimer's Society and Race Against Dementia, who we thank for their ongoing support. -- Follow us on Social Media: https://www.instagram.com/dementia_researcher/ https://www.facebook.com/Dementia.Researcher/ https://twitter.com/demrescommunity https://www.linkedin.com/company/dementia-researcher https://bsky.app/profile/dementiaresearcher.bsky.social

Dr Clíona Farrell, narrating her blog written for the Dementia Researcher website. In this blog, Clíona explores the challenge of facing an uncertain future as her first postdoc contract nears its end. Choosing to take a career break for travel without a fixed plan in place, she reflects on her discomfort with uncertainty, the pressure of well-meaning questions from others, and the wider instability faced by early career researchers. While offering no tidy solutions, Clíona shares what's helping her cope, and invites others to join the conversation about managing change and the unknown. Find the original text, and narration here on our website. https://www.dementiaresearcher.nihr.ac.uk/blog-how-to-be-okay-facing-the-unknown/ -- Dr Clíona Farrell is a Postdoctoral Researcher in the UK Dementia Research Institute at University College London. Her work focuses on understanding neuroinflammation in Down syndrome, both prior to, and in response to, Alzheimer's disease pathology. Originally from Dublin, Ireland, Clíona completed her undergraduate degree in Neuroscience in Trinity College, and then worked as a research assistant in the Royal College of Surgeons studying ALS and Parkinson's disease. She also knows the secret behind scopping the perfect 99 ice-cream cone. @ClionaFarrell_ -- Enjoy listening? We're always looking for new bloggers, drop us a line. http://www.dementiaresearcher.nihr.ac.uk This podcast is brought to you in association with Alzheimer's Association, Alzheimer's Research UK, Alzheimer's Society and Race Against Dementia, who we thank for their ongoing support. -- Follow us on Social Media: https://www.instagram.com/dementia_researcher/ https://www.facebook.com/Dementia.Researcher/ https://twitter.com/demrescommunity https://www.linkedin.com/company/dementia-researcher https://bsky.app/profile/dementiaresearcher.bsky.social

Dr Clíona Farrell, narrating her blog written for the Dementia Researcher website. In this blog, Clíona reflects on the step-by-step process of getting her first first-author data paper published. Drawing on a project that began during her PhD and continued into her postdoc, Clíona highlights the many layers of work involved – from early authorship discussions to final submission and revisions. Her account underscores how time-consuming, iterative, and unexpectedly complex academic publishing can be, offering an honest and practical perspective for researchers navigating their first manuscript journey. Find the original text, and narration here on our website. https://www.dementiaresearcher.nihr.ac.uk/blog-first-time-through-the-publication-process/ -- Dr Clíona Farrell is a Postdoctoral Researcher in the UK Dementia Research Institute at University College London. Her work focuses on understanding neuroinflammation in Down syndrome, both prior to, and in response to, Alzheimer's disease pathology. Originally from Dublin, Ireland, Clíona completed her undergraduate degree in Neuroscience in Trinity College, and then worked as a research assistant in the Royal College of Surgeons studying ALS and Parkinson's disease. She also knows the secret behind scopping the perfect 99 ice-cream cone. @ClionaFarrell_ -- Enjoy listening? We're always looking for new bloggers, drop us a line. http://www.dementiaresearcher.nihr.ac.uk This podcast is brought to you in association with Alzheimer's Association, Alzheimer's Research UK, Alzheimer's Society and Race Against Dementia, who we thank for their ongoing support. -- Follow us on Social Media: https://www.instagram.com/dementia_researcher/ https://www.facebook.com/Dementia.Researcher/ https://twitter.com/demrescommunity https://www.linkedin.com/company/dementia-researcher https://bsky.app/profile/dementiaresearcher.bsky.social

This year's AD/PD Conference was held in Vienna, Austria from the 1st to 5th April. In this first of a two-part special we bring you highlights from the first three days of the conference. The AD/PD Conference focuses on basic science and translational and clinical research bringing New insights on disease mechanisms and etiologies, the latest findings from clinical trials, innovative outlooks on therapy and prevention and advances in diagnostic markers. In this special on-location recording our guest host Dr Amanda Heslegrave, Principle Investigator and Co-Lead of fluid biomarker laboratory from the UK Dementia Research Institute at University College London talks with: Dr Loukia Katsouri, Senior Research Fellow at the UCL Gatsby Foundation. Loukia studies the molecular mechanisms of tau propagation in Alzheimer's disease. She aims to understand how the presence of tau is affecting the spread and the severity of the disease. Dr Anna Mallach, Research Fellow in the UK Dementia Research Institute at Imperial College London. Anna's work focusses on understanding the role of cellular interactions in contributing to neurodegenerative diseases. Dr Imogen Swift, Research Scientist at Vesper Bio. Imogen is a neuroscience specialist focusing on biomarker and preclinical development in neurodegenerative therapeutics spanning frontotemporal dementia, Alzheimer's Disease. Here are just a few highlights from the discussion:

Dr Clíona Farrell, narrating her blog written for the Dementia Researcher website. In this blog, Clíona reflects on her experience at the UK DRI Vascular ECR conference, where patient and public involvement and engagement (PPIE) was embedded throughout the event. From shaping research discussions to helping early career researchers improve accessibility, Clíona shares how the inclusion of lived experience experts made the conference more insightful, collaborative, and engaging. She argues that PPIE isn't just for clinical researchers – it benefits preclinical science too and should be a standard part of the research process. Find the original text, and narration here on our website. https://www.dementiaresearcher.nihr.ac.uk/blog-how-ppie-involvement-can-improve-a-conference/ -- Dr Clíona Farrell is a Postdoctoral Researcher in the UK Dementia Research Institute at University College London. Her work focuses on understanding neuroinflammation in Down syndrome, both prior to, and in response to, Alzheimer's disease pathology. Originally from Dublin, Ireland, Clíona completed her undergraduate degree in Neuroscience in Trinity College, and then worked as a research assistant in the Royal College of Surgeons studying ALS and Parkinson's disease. She also knows the secret behind scopping the perfect 99 ice-cream cone. @ClionaFarrell_ -- Enjoy listening? We're always looking for new bloggers, drop us a line. http://www.dementiaresearcher.nihr.ac.uk This podcast is brought to you in association with Alzheimer's Association, Alzheimer's Research UK, Alzheimer's Society and Race Against Dementia, who we thank for their ongoing support. -- Follow us on Social Media: https://www.instagram.com/dementia_researcher/ https://www.facebook.com/Dementia.Researcher/ https://twitter.com/demrescommunity https://www.linkedin.com/company/dementia-researcher https://bsky.app/profile/dementiaresearcher.bsky.social

Last week we were in Birmingham for this years Alzheimer's Research UK Conference. Hearing from researchers talking about their work and to learn about the latest discoveries in dementia research. In the show guest host and regular blogger Rebecca Williams talks with Dr Beth Williams, from the UK Dementia Research Institute at The University of Edinburgh, Gargi Roy from Bristol Medical School and Donatella Di Rienzo from the Alzheimer's Research UK Oxford Drug Discovery Institute. -- For more information on the event and the great work of Alzheimer's Research UK visit https://www.alzheimersresearchuk.org/research/for-researchers/research-conference Full biographies on all our guests and a transcript can be found on our website: https://www.dementiaresearcher.nihr.ac.uk -- Like what you hear? Please review, like, and share our podcast - and don't forget to subscribe to ensure you never miss an episode – and if you prefer to watch rather than listen, you'll find a video version of this podcast with full captions on our YouTube Channel: youtu.be/fuB4Y2KSt94 -- This podcast is brought to you by University College London / UCLH NIHR Biomedical Research Centre in association with Alzheimer's Association, Alzheimer's Research UK, Alzheimer's Society and Race Against Dementia who we thank for their ongoing support. -- Follow us on Social Media: www.instagram.com/dementia_researcher/ www.facebook.com/Dementia.Researcher/ twitter.com/demrescommunity www.bsky.app/profile/dementiare…archer.bsky.social www.linkedin.com/company/dementia-researcher

Dr Clíona Farrell, narrating her blog written for the Dementia Researcher website. Clíona shares her experience of peer reviewing a research paper for the first time, reflecting on the challenges, learning process, and confidence needed to take on this key academic role. From tackling imposter syndrome to using structured resources and thoughtful feedback, she offers valuable insights for early career researchers looking to step into peer review. Find the original text, and narration here on our website. https://www.dementiaresearcher.nihr.ac.uk/blog-my-first-time-as-a-peer-reviewer/ -- Dr Clíona Farrell is a Postdoctoral Researcher in the UK Dementia Research Institute at University College London. Her work focuses on understanding neuroinflammation in Down syndrome, both prior to, and in response to, Alzheimer's disease pathology. Originally from Dublin, Ireland, Clíona completed her undergraduate degree in Neuroscience in Trinity College, and then worked as a research assistant in the Royal College of Surgeons studying ALS and Parkinson's disease. She also knows the secret behind scopping the perfect 99 ice-cream cone. @ClionaFarrell_ -- Enjoy listening? We're always looking for new bloggers, drop us a line. http://www.dementiaresearcher.nihr.ac.uk This podcast is brought to you in association with Alzheimer's Association, Alzheimer's Research UK, Alzheimer's Society and Race Against Dementia, who we thank for their ongoing support. -- Follow us on Social Media: https://www.instagram.com/dementia_researcher/ https://www.facebook.com/Dementia.Researcher/ https://twitter.com/demrescommunity https://www.linkedin.com/company/dementia-researcher https://bsky.app/profile/dementiaresearcher.bsky.social

Episode Links: Write down your thoughts and shred them to relieve anger, researchers say How to Deal with Guilt: 14 Tips for Coping YOUR FEAR IS BORING. I can say this with all honesty and authority, because I k… Life doesn't happen to you, it happens for you How to Help Others Through a Difficult Transition Kaleidoscope Health and Care 9 Things to Do When Change Is Forced on You The Imposter Syndrome One The “in-between” times of transition are amazing opportunities for growth and reflection. Transition is an Opportunity for Growth The power of a slow transition Transition The Power Of Curiosity In The Workplace   Our first guests is Chrysa Vazitari. Chrysa is a silver award winner as the best EMEA coach. She is focusing on career advancement, career pivots and burnout prevention. She is a PCC-certified coach by ICF and she is using different methodologies in her coaching like LEGO Serious Play, phototherapy, embodiment to support the self-discovery and to keep her sessions and workshops fun and engaging.  https://www.linkedin.com/in/chrysanthi-vazitari/ website link:  https://www.chrysalogy.com/   Krystyna Mailer is an instructional and graphic design specialist with expertise in visual communication, e-learning course development, video creation and job aid design. Known for her ability to transform complex information into clear and engaging learning materials, her mission is to create solutions that are both impactful and practical. She has an instagram and a TikTok page sharing tools, tips and practices on instructional design @learningdesigntime and a portfolio website www.krystynamailer.com https://www.linkedin.com/in/krystyna-mailer/   Juliet Morris is a multi-award-winning leader and coach dedicated to helping people create purpose-driven, sustainable futures. With expertise in leadership, sensemaking, and coaching (Clean Language, executive coaching, and mental fitness), she partners with those seeking meaningful progress. Currently, Juliet is Chief People & Culture Officer at the UK Dementia Research Institute.   In her spare time, Juliet writes a weekly newsletter, "I.F. Club," hosts thought-provoking podcasts, volunteers at school career events, and serves as a delegate for UN Women UK. She's also training in five-element acupuncture. LinkedIn: Juliet Morris Subscribe: I.F. Club Listen: What Kind of Future?   You can contact Women Talking About Learning through our website, womentalkingaboutlearning.com We're on Twitter @WTAL_Podcast You can buy us a coffee to support Women Talking About Learning via Ko-Fi. Or you can email us via hello@llarn.com

Dr Clíona Farrell, narrating her blog written for the Dementia Researcher website. Clíona shares her experience of a collaborative research visit to a US lab, detailing the planning process, securing funding, and navigating visa requirements. She highlights the benefits of international collaborations, from accessing rare samples to gaining new research perspectives. Clíona provides practical advice on networking, early planning, and making the most of the visit, including shadowing new techniques and engaging with other researchers. Reflecting on her time in California, she emphasises the professional and personal growth gained from the experience and encourages others to explore similar opportunities. Find the original text, and narration here on our website. https://www.dementiaresearcher.nihr.ac.uk/blog-experience-from-a-collaborative-research-trip/ -- Dr Clíona Farrell is a Postdoctoral Researcher in the UK Dementia Research Institute at University College London. Her work focuses on understanding neuroinflammation in Down syndrome, both prior to, and in response to, Alzheimer's disease pathology. Originally from Dublin, Ireland, Clíona completed her undergraduate degree in Neuroscience in Trinity College, and then worked as a research assistant in the Royal College of Surgeons studying ALS and Parkinson's disease. She also knows the secret behind scopping the perfect 99 ice-cream cone. @ClionaFarrell_ -- Enjoy listening? We're always looking for new bloggers, drop us a line. http://www.dementiaresearcher.nihr.ac.uk This podcast is brought to you in association with Alzheimer's Association, Alzheimer's Research UK, Alzheimer's Society and Race Against Dementia, who we thank for their ongoing support. -- Follow us on Social Media: https://www.instagram.com/dementia_researcher/ https://www.facebook.com/Dementia.Researcher/ https://twitter.com/demrescommunity https://www.linkedin.com/company/dementia-researcher https://bsky.app/profile/dementiaresearcher.bsky.social

Greg and Matias interview Dr. Nir Grossman, one of the world's leading researchers in neurotechnology. Nir is a lecturer in the Department of Brain Sciences at Imperial College London and a founding fellow of the UK Dementia Research Institute. In this episode, we discuss:What is temporal interference (TI), a non-invasive stimulation methodA comparison of TI with deep brain stimulation (DBS)How physics plays a crucial role in neuroscience innovationTranslating TI academic research to clinical useTI's role in treating Alzheimer's, epilepsy, depression, and traumatic brain injuryCredits:Created by Greg Kubin and Matias SerebrinskyHost: Matias Serebrinsky & Greg KubinProduced by Jonathan A. Davis,  Nico V. Rey & Caitlin NerFind us at businesstrip.fm and psymed.venturesFollow us on Instagram and Twitter!Theme music by Dorian LoveAdditional Music: Distant Daze by Zack Frank

Dr Clíona Farrell, narrating her blog written for the Dementia Researcher website. Explore the lesser-known yet vital aspect of Alzheimer's disease in our latest blog from Clíona. This post gets into the complex world of amyloid-β deposition within the brain's blood vessels. Clíona is embarking on a new postdoc project focused on this area, and in this article she shares insights into how Cerebral Amyloid Angiopathy (CAA) not only coexists with Alzheimer's but also significantly impacts disease pathology and patient outcomes. Discover the implications of recent anti-amyloid therapies and why understanding CAA is crucial for future Alzheimer's treatments. Find the original text, and narration here on our website. https://www.dementiaresearcher.nihr.ac.uk/blog-a-vascular-element-of-alzheimers-cerebral-amyloid-angiopathy/ -- Dr Clíona Farrell is a Postdoctoral Researcher in the UK Dementia Research Institute at University College London. Her work focuses on understanding neuroinflammation in Down syndrome, both prior to, and in response to, Alzheimer's disease pathology. Originally from Dublin, Ireland, Clíona completed her undergraduate degree in Neuroscience in Trinity College, and then worked as a research assistant in the Royal College of Surgeons studying ALS and Parkinson's disease. She also knows the secret behind scopping the perfect 99 ice-cream cone. @ClionaFarrell_ -- Enjoy listening? We're always looking for new bloggers, drop us a line. http://www.dementiaresearcher.nihr.ac.uk This podcast is brought to you in association with Alzheimer's Association, Alzheimer's Research UK, Alzheimer's Society and Race Against Dementia, who we thank for their ongoing support. -- Follow us on Social Media: https://www.instagram.com/dementia_researcher/ https://www.facebook.com/Dementia.Researcher/ https://twitter.com/demrescommunity https://www.linkedin.com/company/dementia-researcher https://bsky.app/profile/dementiaresearcher.bsky.social

Dr Clíona Farrell, narrating her blog written for the Dementia Researcher website. Clíona discusses her decision to transition from PhD student to postdoc in the same lab, weighing the benefits and potential drawbacks. She reflects on the comfort of familiar surroundings and established relationships, which helped her dive straight into new projects and finalise her PhD work. Yet, this continuity also brings unique challenges, from overlapping responsibilities to the risk of limited career progression if not carefully navigated. Clíona's insights offer a nuanced look at whether staying put can be the right path for early-career researchers. Find the original text, and narration here on our website. https://www.dementiaresearcher.nihr.ac.uk/blog-should-you-stay-pros-and-cons-of-postdocing-in-your-phd-lab/ #PhDPosition #PhDLife #PhDFunding #PhDApplications -- Dr Clíona Farrell is a Postdoctoral Researcher in the UK Dementia Research Institute at University College London. Her work focuses on understanding neuroinflammation in Down syndrome, both prior to, and in response to, Alzheimer's disease pathology. Originally from Dublin, Ireland, Clíona completed her undergraduate degree in Neuroscience in Trinity College, and then worked as a research assistant in the Royal College of Surgeons studying ALS and Parkinson's disease. She also knows the secret behind scopping the perfect 99 ice-cream cone. @ClionaFarrell_ -- Enjoy listening? We're always looking for new bloggers, drop us a line. http://www.dementiaresearcher.nihr.ac.uk This podcast is brought to you in association with Alzheimer's Association, Alzheimer's Research UK, Alzheimer's Society and Race Against Dementia, who we thank for their ongoing support. -- Follow us on Social Media: https://www.instagram.com/dementia_researcher/ https://www.facebook.com/Dementia.Researcher/ https://twitter.com/demrescommunity https://www.linkedin.com/company/dementia-researcher https://bsky.app/profile/dementiaresearcher.bsky.social

Dr Clíona Farrell, narrating her blog written for the Dementia Researcher website. Clíona shares a typical week looks like for a PhD student. From lab work and data analysis to committee meetings and outreach events, Clíona shares her experiences from each year of her PhD, offering valuable insights into the challenges and rewards of life as a researcher. Whether you're considering a PhD or just curious about the process, this blog provides an honest look at the variety and commitment involved in pursuing a research career. Find the original text, and narration here on our website. https://www.dementiaresearcher.nihr.ac.uk/blog-journey-to-a-phd-a-week-in-the-life-of-a-phd-student/ #PhDPosition #PhDLife #PhDFunding #PhDApplications -- Dr Clíona Farrell is a Postdoctoral Researcher in the UK Dementia Research Institute at University College London. Her work focuses on understanding neuroinflammation in Down syndrome, both prior to, and in response to, Alzheimer's disease pathology. Originally from Dublin, Ireland, Clíona completed her undergraduate degree in Neuroscience in Trinity College, and then worked as a research assistant in the Royal College of Surgeons studying ALS and Parkinson's disease. She also knows the secret behind scopping the perfect 99 ice-cream cone. @ClionaFarrell_ -- Enjoy listening? We're always looking for new bloggers, drop us a line. http://www.dementiaresearcher.nihr.ac.uk This podcast is brought to you in association with Alzheimer's Association, Alzheimer's Research UK, Alzheimer's Society and Race Against Dementia, who we thank for their ongoing support. -- Follow us on Social Media: https://www.instagram.com/dementia_researcher/ https://www.facebook.com/Dementia.Researcher/ https://twitter.com/demrescommunity https://www.linkedin.com/company/dementia-researcher https://bsky.app/profile/dementiaresearcher.bsky.social

Dr Clíona Farrell, narrating her blog written for the Dementia Researcher website. In the second of her three-part series Clíona offers practical advice for those applying to PhD programmes. She begins by discussing the importance of tailoring applications to specific projects and carefully reading job descriptions to meet both essential and desirable criteria. Clíona outlines the key components of a standout application: a clear, concise CV that highlights relevant education, research experience, and skills, and a personalised cover letter that demonstrates enthusiasm for the project and lab.   She recommends structuring the cover letter into two parts: the first part focuses on how the applicant's skills and experience make them suitable for the position, using evidence-based examples, while the second part explains why they are interested in the specific lab and project. Dr Farrell emphasises the importance of proofreading and personalising each application to improve chances of success. Remember... not to be discouraged by missing one or two skills and apply confidently. Find the original text, and narration here on our website. https://www.dementiaresearcher.nihr.ac.uk/blog-how-to-write-a-standout-cv-and-cover-letter/ #PhDPosition #PhDLife #PhDFunding #PhDApplications -- Dr Clíona Farrell is a Postdoctoral Researcher in the UK Dementia Research Institute at University College London. Her work focuses on understanding neuroinflammation in Down syndrome, both prior to, and in response to, Alzheimer's disease pathology. Originally from Dublin, Ireland, Clíona completed her undergraduate degree in Neuroscience in Trinity College, and then worked as a research assistant in the Royal College of Surgeons studying ALS and Parkinson's disease. She also knows the secret behind scopping the perfect 99 ice-cream cone. @ClionaFarrell_ -- Enjoy listening? We're always looking for new bloggers, drop us a line. http://www.dementiaresearcher.nihr.ac.uk This podcast is brought to you in association with Alzheimer's Association, Alzheimer's Research UK, Alzheimer's Society and Race Against Dementia, who we thank for their ongoing support. -- Follow us on Social Media: https://www.instagram.com/dementia_researcher/ https://www.facebook.com/Dementia.Researcher/ https://twitter.com/demrescommunity https://www.linkedin.com/company/dementia-researcher https://bsky.app/profile/dementiaresearcher.bsky.social

Dr Clíona Farrell, narrating her blog written for the Dementia Researcher website. In the first of her three-part series Clíona shares her personal journey to obtaining a PhD, offering insights into the challenges and decisions she faced along the way. From her undergraduate experience at Trinity College Dublin to working as a research assistant in Ireland, Clíona reflects on how she navigated the uncertainty of whether a PhD was the right path for her. She emphasises the importance of gaining lab experience, working in diverse teams, and seeking mentorship. Clíona also discusses the application process, the role of advertised PhD positions, and encourages aspiring researchers to be proactive in reaching out to potential supervisors. Her story highlights that there are many routes to a PhD and offers practical advice for those considering this path. Find the original text, and narration here on our website. https://www.dementiaresearcher.nihr.ac.uk/blog-journey-to-a-phd-how-to-get-there/ #PhDPosition #PhDLife #PhDFunding #PhDApplications -- Dr Clíona Farrell is a Postdoctoral Researcher in the UK Dementia Research Institute at University College London. Her work focuses on understanding neuroinflammation in Down syndrome, both prior to, and in response to, Alzheimer's disease pathology. Originally from Dublin, Ireland, Clíona completed her undergraduate degree in Neuroscience in Trinity College, and then worked as a research assistant in the Royal College of Surgeons studying ALS and Parkinson's disease. She also knows the secret behind scopping the perfect 99 ice-cream cone. @ClionaFarrell_ -- Enjoy listening? We're always looking for new bloggers, drop us a line. http://www.dementiaresearcher.nihr.ac.uk This podcast is brought to you in association with Alzheimer's Association, Alzheimer's Research UK, Alzheimer's Society and Race Against Dementia, who we thank for their ongoing support. -- Follow us on Social Media: https://www.instagram.com/dementia_researcher/ https://www.facebook.com/Dementia.Researcher/ https://twitter.com/demrescommunity https://www.linkedin.com/company/dementia-researcher https://bsky.app/profile/dementiaresearcher.bsky.social

Dr Clíona Farrell, narrating her blog written for the Dementia Researcher website. Clíona discusses the importance of understanding your audience in effective science communication. She emphasises that communicating scientific research requires tailoring the content and presentation style to different audiences, whether they are laypeople, students, or individuals with specific needs. Through various examples from her experiences, she highlights the importance of engaging the audience by relating scientific findings to broader, more relatable contexts and ensuring accessibility in both language and format. This blog underscores the significance of being well-prepared, respectful, and aware of current developments in the field to facilitate meaningful engagement and avoid alienating the audience. Find the original text, and narration here on our website. https://www.dementiaresearcher.nihr.ac.uk/blog-communicating-your-science-effectively-know-your-audience/ #DementiaResearch #DownSyndrome #ScienceCommunications -- Dr Clíona Farrell is a Postdoctoral Researcher in the UK Dementia Research Institute at University College London. Her work focuses on understanding neuroinflammation in Down syndrome, both prior to, and in response to, Alzheimer's disease pathology. Originally from Dublin, Ireland, Clíona completed her undergraduate degree in Neuroscience in Trinity College, and then worked as a research assistant in the Royal College of Surgeons studying ALS and Parkinson's disease. She also knows the secret behind scopping the perfect 99 ice-cream cone. @ClionaFarrell_ -- Enjoy listening? We're always looking for new bloggers, drop us a line. http://www.dementiaresearcher.nihr.ac.uk This podcast is brought to you in association with Alzheimer's Association, Alzheimer's Research UK, Alzheimer's Society and Race Against Dementia, who we thank for their ongoing support. -- Follow us on Social Media: https://www.instagram.com/dementia_researcher/ https://www.facebook.com/Dementia.Researcher/ https://twitter.com/demrescommunity https://www.linkedin.com/company/dementia-researcher https://bsky.app/profile/dementiaresearcher.bsky.social

Dr Clíona Farrell, narrating her blog written for the Dementia Researcher website. Clíona she shares highlights from the 2024 International Trisomy 21 Research Society (T21RS) conference in Rome. Focusing on Alzheimer's disease in individuals with Down syndrome, Clíona discusses the latest research advancements, the genetic link between Down syndrome and Alzheimer's, and the critical need for inclusive clinical trials. The blog also emphasises the conference's commitment to accessibility and inclusivity, featuring engaging sessions for researchers, individuals with Down syndrome, and their families.    Find the original text, and narration here on our website. https://www.dementiaresearcher.nihr.ac.uk/blog-news-from-the-trisomy-21-research-society-conference/ #DementiaResearch #DownSyndrome #Trisomy21 -- Dr Clíona Farrell is a Postdoctoral Researcher in the UK Dementia Research Institute at University College London. Her work focuses on understanding neuroinflammation in Down syndrome, both prior to, and in response to, Alzheimer's disease pathology. Originally from Dublin, Ireland, Clíona completed her undergraduate degree in Neuroscience in Trinity College, and then worked as a research assistant in the Royal College of Surgeons studying ALS and Parkinson's disease. She also knows the secret behind scopping the perfect 99 ice-cream cone. @ClionaFarrell_   -- Enjoy listening? We're always looking for new bloggers, drop us a line. http://www.dementiaresearcher.nihr.ac.uk This podcast is brought to you in association with Alzheimer's Association, Alzheimer's Research UK, Alzheimer's Society and Race Against Dementia, who we thank for their ongoing support. -- Follow us on Social Media: https://www.instagram.com/dementia_researcher/ https://www.facebook.com/Dementia.Researcher/ https://twitter.com/demrescommunity https://www.linkedin.com/company/dementia-researcher

In this episode of the Epigenetics Podcast, we talked with Sarah Marzi from the UK Dementia Research Institute at Imperial College London about her work on epigenetic changes in Alzheimer's Disease, and comparing CUT&Tag to ENCODE ChIP-Seq using limited cell samples. The interview discusses Sarah Marzi's work on ChIP-Seq experiments and their significance in understanding Alzheimer's disease from an epigenetic perspective. The discussion touches on the widespread dysregulation and changes in acetylation, particularly in genes associated with Alzheimer's risk, providing insights into potential links between epigenetic insults and disease onset. Moving on to the technical aspects of the study, the interview examines the strategic use of CUT&Tag. It explores the challenges and optimizations involved in accurately profiling limited cell samples. The dialogue also compares CUT&Tag to ENCODE ChIP-Seq, highlighting the complexities of peak calling and data interpretation across different methodologies.   References Kumsta, R., Marzi, S., Viana, J. et al. Severe psychosocial deprivation in early childhood is associated with increased DNA methylation across a region spanning the transcription start site of CYP2E1. Transl Psychiatry 6, e830 (2016). https://doi.org/10.1038/tp.2016.95 Marzi, S. J., Schilder, B. M., Nott, A., Frigerio, C. S., Willaime‐Morawek, S., Bucholc, M., Hanger, D. P., James, C., Lewis, P. A., Lourida, I., Noble, W., Rodriguez‐Algarra, F., Sharif, J., Tsalenchuk, M., Winchester, L. M., Yaman, Ü., Yao, Z., The Deep Dementia Phenotyping (DEMON) Network, Ranson, J. M., & Llewellyn, D. J. (2023). Artificial intelligence for neurodegenerative experimental models. Alzheimer's & Dementia, 19(12), 5970–5987. https://doi.org/10.1002/alz.13479 Marzi, S. J., Leung, S. K., Ribarska, T., Hannon, E., Smith, A. R., Pishva, E., Poschmann, J., Moore, K., Troakes, C., Al-Sarraj, S., Beck, S., Newman, S., Lunnon, K., Schalkwyk, L. C., & Mill, J. (2018). A histone acetylome-wide association study of Alzheimer's disease identifies disease-associated H3K27ac differences in the entorhinal cortex. Nature Neuroscience, 21(11), 1618–1627. https://doi.org/10.1038/s41593-018-0253-7 Hu, D., Abbasova, L., Schilder, B. M., Nott, A., Skene, N. G., & Marzi, S. J. (2022). CUT&Tag recovers up to half of ENCODE ChIP-seq peaks in modifications of H3K27 [Preprint]. Genomics. https://doi.org/10.1101/2022.03.30.486382   Related Episodes When is a Peak a Peak? (Claudio Cantù) Development of Integrative Machine Learning Tools for Neurodegenerative Diseases (Enrico Glaab) DNA Methylation Alterations in Neurodegenerative Diseases (Paula Desplats)   Contact Epigenetics Podcast on X Epigenetics Podcast on Instagram Epigenetics Podcast on Mastodon Epigenetics Podcast on Bluesky Epigenetics Podcast on Threads Active Motif on X Active Motif on LinkedIn Email: podcast@activemotif.com

Thanks to Sannia Farrukh and the ICGEB for their support in making this show!It's thought that by the end of the decade, 78 million people around the world will have Alzheimer's disease. It's debilitating and progressive. It robs people of their personality, their independence, and their quality of life. And caring for people with the condition, which often goes on over many years, is extremely costly, both financially and emotionally. The biggest risk factor is age; and as the proportion of the population living into their 80s, when as many as a fifth of individuals can develop the condition,... Like this podcast? Please help us by supporting the Naked Scientists

This year's AD/PD Conference was held in Lisbon, Portugal from the 5th to 9th March. In this second of a two-part special we bring you highlights from the last few days of the conference. The AD/PD Conference focuses on basic science and translational and clinical research bringing New insights on disease mechanisms and etiologies, the latest findings from clinical trials, innovative outlooks on therapy and prevention and advances in diagnostic markers. In this special on-location recording our guest host Dr Emily Maguire, Senior Research Associate from the UK Dementia Research Institute at Cardiff University talks with: Dr Daniel Erskine, Senior Lecturer at Newcastle University. Dr Heather Snyder, Alzheimer's Association Vice President, Medical & Scientific Relations & Dr Timothy Siegert, Co-Founder, President & COO of Allyx Therapeutics. -- For more information on the event visit: https://adpd.kenes.com/ Full biographies on all our guests and a transcript can be found on our website: https://www.dementiaresearcher.nihr.ac.uk -- Like what you hear? Please review, like, and share our podcast - and don't forget to subscribe to ensure you never miss an episode – and if you prefer to watch rather than listen, you'll find a video version of this podcast on our YouTube Channel https://youtu.be/154FZrzwLwE This podcast is brought to you by University College London / UCLH NIHR Biomedical Research Centre in association with Alzheimer's Association, Alzheimer's Research UK, Alzheimer's Society and Race Against Dementia who we thank for their ongoing support. -- Follow us on Social Media: http://www.instagram.com/dementia_researcher/ http://www.facebook.com/Dementia.Researcher/ http://twitter.com/demrescommunity http://bsky.app/profile/dementiaresearcher.bsky.social http://www.linkedin.com/company/dementia-researcher #dementiaresearch #adpd2024 #ADPDConference

This year's AD/PD Conference was held in Lisbon, Portugal from the 5th to 9th March. In this first of a two-part special we bring you highlights from the first three days of the conference. The AD/PD Conference focuses on basic science and translational and clinical research bringing New insights on disease mechanisms and etiologies, the latest findings from clinical trials, innovative outlooks on therapy and prevention and advances in diagnostic markers. In this special on-location recording our guest host Dr Amanda Heslegrave, Senior Research Associate and Co-Lead of fluid biomarker laboratory from the UK Dementia Research Institute at University College London talks with: Dr Ian Harrison, Senior Research Fellow at University College London studying the role of clearance systems in the brain, and their involvement in the development and treatment of neurodegenerative diseases. Dr Ariana Gatt, Senior Research Fellow at University College London investigating the role of RNA-binding proteins in neurodegenerative disease with a focus on Frontotemporal dementia. Jess Tobin, Science Communications Manager at Alzheimer's Research UK. -- For more information on the event visit: adpd.kenes.com/ Full biographies on all our guests and a transcript can be found on our website: https://www.dementiaresearcher.nihr.ac.uk -- Like what you hear? Please review, like, and share our podcast - and don't forget to subscribe to ensure you never miss an episode – and if you prefer to watch rather than listen, you'll find a video version of this podcast on our YouTube Channel youtu.be/UQdm8aWuoFM This podcast is brought to you by University College London / UCLH NIHR Biomedical Research Centre in association with Alzheimer's Association, Alzheimer's Research UK, Alzheimer's Society and Race Against Dementia who we thank for their ongoing support. -- Follow us on Social Media: http://www.instagram.com/dementia_researcher/ http://www.facebook.com/Dementia.Researcher/ http://twitter.com/demrescommunity http://bsky.app/profile/dementiaresearcher.bsky.social http://www.linkedin.com/company/dementia-researcher #dementiaresearch #adpd2024 #ADPDConference

Dr Adrien Rapeaux, Research Associate at Imperial College London (UK) Neural Engineering Lead at Mintneuro (Imperial College Spinout – Mintneuro designs chips for implantable neural interfaces) Researcher at the UK Dementia Research Institute, Care Research & Technology Centre With guest host Rob Breakenridge Learn more about your ad choices. Visit megaphone.fm/adchoices

Join PhD Student and Guest Host Rebecca Williams as she explores the often intricate and crucial world of research ethics approvals and participant consent in dementia research. Rebecca is joined by experts: Dr. Anna Volkmer, a Senior Research Fellow at University College London, Dr. Victoria Shepherd, Senior Fellow from Cardiff University, and Danielle Wilson, Head of Commercialisation and Ethics Chair from the UK Dementia Research Institute at Imperial College London. Our panelists bring a wealth of experience from various backgrounds, including speech and language therapy, nursing, research delivery, capacity evaluation, consent and health research ethics. They offer invaluable insights into the ethical, legal, and practical challenges of involving people with dementia and other conditions in research. The discussion covers a range of topics including the basics of research ethics, how to apply and manage participant consent, with tips for new applicants and goes further to explore the evolving landscape of research ethics in the age of emerging technologies like AI. This episode is a must-listen for anyone researchers involved in health and social care. Whether you're a seasoned researcher or new to the field, and making your first ethics application this show offers a unique opportunity to hear from experts who have led ethics panels and navigated these challenges themselves. -- Resources discussed in the show: HRA - Research Ethics Service and Research Ethics Committees https://bit.ly/3SnhNm8 HRA - What approvals and decisions do I need? https://bit.ly/3u6MtyF NIHR INCLUDE Impaired Capacity to Consent Framework https://bit.ly/3vJ39Nq -- Full biographies on all our guests and a transcript can be found on our website https://www.dementiaresearcher.nihr.ac.uk -- Like what you hear? Please review, like, and share our podcast - and don't forget to subscribe to ensure you never miss an episode – and if you prefer to watch rather than listen, you'll find a video version of this podcast on our website and YouTube Channel, with closed captions. https://youtu.be/lpcLXaBxpTE -- This podcast is brought to you in association with Alzheimer's Association, Alzheimer's Research UK, Alzheimer's Society and Race Against Dementia, who we thank for their ongoing support. -- Follow us on Social Media: https://www.instagram.com/dementia_researcher/ https://www.facebook.com/Dementia.Researcher/ https://twitter.com/demrescommunity https://bsky.app/profile/dementiaresearcher.bsky.social https://www.linkedin.com/company/dementia-researcher

Dr Fiona McLean, ARUK Research Fellow, University of Dundee is joined by fellow experts Dr Kate Harris and Dr Sophie Morse, to explore the intricacies of the blood-brain barrier and its pivotal role in dementia research. They discuss pioneering methods in overcoming the barrier for drug delivery, the significance of endothelial cells in barrier integrity, and novel approaches in treating neurodegenerative diseases. The conversation also touches on the collaborative nature of neuroscience, offering invaluable insights for newcomers to the field. Don't miss this deep dive into the forefront of dementia research. -- Meet the guests: Dr Sophie Morse is a Research Fellow & UK DRI Emerging Leader at Imperial College London, within the UK Dementia Research Institute. Sophie is a biomedical engineer who leads a research group exploring the use of Therapeutic Ultrasound for Brain Diseases. Dr Kate Harris is an Academic Track Alzheimer's Research UK Fellow in Drug Discovery at Newcastle University. Kate is working on finding new drug targets for neurodegenerative disease in neuroinflammation. -- Links mentioned in the show: Rapid short-pulses of focused ultrasound and microbubbles deliver a range of agent sizes to the brain - https://bit.ly/41PFvuh -- Full biographies on all our guests and a transcript can be found on our website https://www.dementiaresearcher.nihr.ac.uk -- Like what you hear? Please review, like, and share our podcast - and don't forget to subscribe to ensure you never miss an episode – and if you prefer to watch rather than listen, you'll find a video version of this podcast on our website and YouTube Channel, with closed captions. https://youtu.be/1x_6ij9N6pU -- This podcast is brought to you in association with Alzheimer's Association, Alzheimer's Research UK, Alzheimer's Society and Race Against Dementia, who we thank for their ongoing support. -- Follow us on Social Media: https://www.instagram.com/dementia_researcher/ https://www.facebook.com/Dementia.Researcher/ https://twitter.com/demrescommunity https://bsky.app/profile/dementiaresearcher.bsky.social https://www.linkedin.com/company/dementia-researcher

Science is all about rigorous testing, empirical evidence, and painstaking documentation, right? But even in the most state-of-the-art labs, you'll find researchers who hold on to quirky rituals, lucky charms, or, dare we say it, superstitions. In this podcast, Dr Yvonne Couch, Associate Professor at University of Oxford hosts a discussion that romps through the lighter side of scientific research by exploring the wonderful world of lab superstitions. From lucky pipettes to forbidden phrases, we're about to uncover the unofficial 'do's and don'ts' that researchers swear by, or at least, swear make for good anecdotes. -- This shows guests are: Dr Kamar Ameen-Ali, Lecturer in Biomedical Science at Teeside University. In addition to teaching, Kam is interested in How neuroinflammation following traumatic brain injury contributes to the progression of neurodegenerative diseases (such as Alzheimer's disease) that lead to dementia. Dr Soraya Meftah, Postdoctoral Research Fellow in the UK Dementia Research Institute at The University of Edinburgh. Soraya works in the space of Neurophysiology of dementia (synaptic, neuronal, network dysfunction). Tabitha Broadbelt just completed her PhD at The University of Edinburgh and is now a Postdoctoral Researcher at the MRC Brain Network Dynamics Unity at University of Oxford. In the Dupret Group, Tabitha uses optogenetics and large-scale single-unit recordings combined to study memory-guided behaviour. Dr Lauren Walker is an Alzheimer's Research UK Fellow at Newcastle University. Lauren complete her undergrad degree in Physiological Sciences, and worked in a technical role for 7 years before being inspired to return to study a PhD. Lauren now works in Neuropathology of Lewy body dementia and Alzheimer's disease. -- Full biographies on all our guests and a transcript can be found on our website https://www.dementiaresearcher.nihr.ac.uk -- Like what you hear? Please review, like, and share our podcast - and don't forget to subscribe to ensure you never miss an episode – and if you prefer to watch rather than listen, you'll find a video version of this podcast with full captions on our YouTube Channel -- This podcast is brought to you by University College London / UCLH NIHR Biomedical Research Centre in association with Alzheimer's Association, Alzheimer's Research UK, Alzheimer's Society and Race Against Dementia who we thank for their ongoing support.

According to the World Health Organization, dementia currently affects an estimated 55 million people worldwide. But despite its prevalence, there is very little in the way of effective treatments. In this episode we catch up with Tara Spires-Jones, Professor at the UK Dementia Research Institute at the University of Edinburgh and President of the British Neuroscience Association. She tells us all about the different types of dementia, how they progress and the latest thinking on how we can beat the disease once and for all. Learn more about your ad choices. Visit podcastchoices.com/adchoices

In this podcast we share a few selected highlights from the first day of the Alzheimer's Association International Conference (AAIC) taking place in Amsterdam and Online, 16th – 20th July. Adam Smith hosts the show with special guests Dr Mizuki Morisaki from University of Bristol, Sam Keat, PhD Student in the UK Dementia Research Institute at Cardiff University and Dr Arunima Sikdar a Postdoc Research Associate from University of North Carolina. -- The AAIC brings together distinguished basic scientists, clinical researchers, early career investigators, clinicians and the care research community at the largest and most influential international conference on dementia science. They share theories and breakthroughs while exploring opportunities to accelerate work and elevate careers. For more information visit: https://aaic.alz.org -- You can also enjoy this show as a video podcast on our YouTube Channel. -- Find more information on our guests, and a full transcript of this podcast on our website at: www.dementiaresearcher.nihr.ac.uk/podcast -- The views and opinions expressed by guests in this podcast represent those of the guests and do not necessarily reflect those of NIHR Dementia Researchers, PIA membership, ISTAART or the Alzheimer's Association.

Welcome to another captivating episode of Dementia Researcher, the podcast that delves into the fascinating world of dementia research. In this special edition, we bring you highlights from the renowned BNA 2023 - Festival of Neuroscience, as we sit down with five brilliant researchers to hear their personal experiences and insights. Our guest host this week is Dr Kamar Ameen-Ali, she is joined by Dr Charlie Arber from UCL, Dr Dorothy Tse from Edge Hill University, Dr Nora Bengoa-Vergniory from Anchucarro, Basque Center for Neuroscience and Dr Dayne Beccano-Kelly from the UK Dementia Research Institute at Cardiff University. Join us as we embark on a riveting journey through the festival, where our guests share their best moments, favourite research presentations, and the exciting events that explored academic and research careers. Our guests, as experts in their respective fields, paint a vivid picture of the festival, offering glimpses into the cutting-edge research that caught their attention and ignited their curiosity. They share their thoughts on the emerging trends, innovative methodologies, and potential breakthroughs that could revolutionize our understanding and treatment of dementia. But it's not just about the science. Our guests also shine a light on the various events that focused on academic and research careers. From panels and workshops to networking sessions, they discuss the invaluable opportunities the festival provided to connect with fellow researchers, forge collaborations, and learn from the brightest minds in the field. Whether you're an aspiring researcher, a healthcare professional, or someone affected by dementia, this episode offers a treasure trove of knowledge and inspiration. So, join us as we dive into the enriching world of the BNA 2023 - Festival of Neuroscience through the eyes of these remarkable researchers. Get ready to be inspired, informed, and captivated by the incredible discoveries and the unwavering dedication that fuels the fight against dementia. -- For more information on the event visit: https://meetings.bna.org.uk/bna2023/ Full biographies on all our guests and a transcript can be found on our website: https://www.dementiaresearcher.nihr.ac.uk -- Like what you hear? Please review, like, and share our podcast - and don't forget to subscribe to ensure you never miss an episode – and if you prefer to watch rather than listen, you'll find a video version of this podcast on our YouTube Channel and in Spotify: https://youtu.be/Wi1htbbMsek -- This podcast is brought to you by University College London / UCLH NIHR Biomedical Research Centre in association with Alzheimer's Association, Alzheimer's Research UK, Alzheimer's Society and Race Against Dementia who we thank for their ongoing support.

Consider this podcast as a ‘Lab Setup 101”, we've brought together three newly minted principle investigators to talk about the highs, lows and practical things you need to consider when setting up a new lab – learning from their first-hand experience. Dr Fiona McLean, ARUK Fellow from University of Dundee talks with Dr Claire Durrant, RAD Fellow from The University of Edinburgh, Dr Ian Harrison, Senior Research Fellow from University College London and Dr Dayne Beccano-Kelly, Group Leader in the UK Dementia Research Institute at Cardiff University. Together our guests will guide you through the important things you need to know before embarking on this journey. Everything from locations and space to purchasing equipment, and hiring staff, we'll cover everything you need to get started. Our expert guests will also share their experiences and provide valuable insights to help you avoid common pitfalls and ensure a successful lab setup. So, join us as we explore the essentials of setting up your own lab. -- Meet the guests: Dr Fiona McLean is an Alzheimer's Research UK Fellow at University of Dundee. She is fascinated by the brain and has always been curious about how it works and what keeps it healthy. Her research focuses on the links between obesity, diabetes and neurodegenerative diseases. Dr Claire Durrant is a Race Aganinst Dementia / Dyson Foundation Fellow in the UK Dementia Research Institute at The University of Edinburgh. Her work focuses on understanding the causes and consequences of synapse loss in dementia causing disease such as Alzheimer's disease. She is currently developing living human brain slices as a translational research tool. Dr Ian Harrison is a Senior Research Fellow at University College London. His work looks at the function of the glymphatic system in the brain, responsible for the clearance of protein solutes from the brain parenchyma. Dr Dayne Beccano-Kelly is UKRI Future Leader Fellow and UK Dementia Research Institute Group Leader at Cardiff University. He is working on neurodegeneration focussing on Parkinson's disease and looking at both the temporality of the disorder as well as the role synaptic dysfunction plays. -- Like what you hear? Please review, like, and share our podcast - and don't forget to subscribe to ensure you never miss an episode – and if you prefer to watch rather than listen, you'll find a video version of this podcast with full captions on our YouTube Channel – www.youtube.com/dementiaresearcher -- This podcast is brought to you by University College London / UCLH NIHR Biomedical Research Centre in association with Alzheimer's Association, Alzheimer's Research UK, Alzheimer's Society and Race Against Dementia who we thank for their ongoing support.

This year's AD/PD Conference was held in Gothenburg, Sweden from the 28th March to 1st April. In this second of a two-part special we bring you highlights from last three days of the conference. The AD/PD Conference focuses on basic science and translational and clinical research bringing New insights on disease mechanisms and etiologies, the latest findings from clinical trials, innovative outlooks on therapy and prevention and advances in diagnostic markers. In this special on-location recording our guest host Dr Anna Mallach, Research Fellow from the UK Dementia Research Institute at University College London talks with: Dr Melissa Scholefield, Postdoctoral Research Associate at University of Manchester. Melissa focusses on undertaking Multi-omic analysis of Lewy body dementias. Dr Chi Udeh-Momoh, Research Programme and Biomarker Lead at Imperial College London. Chi has always been fascinated by the brain, how we think, learn and remember; and how these processes can be affected in disease/ alleviated therapeutically. Emily McCann, PhD Student at Queensland Brain Institute, University of Queensland. Emily's research is in cognitive test development for neurodegenerative diseases. She aims to align functional neural changes with the patient cognitive profile, and has developed a series of tests to measure visuoperceptual impairments in patients with Alzheimer's and Lewy Body pathology. For more information on the event visit: https://adpd.kenes.com/ Full biographies on all our guests and a transcript can be found on our website: https://www.dementiaresearcher.nihr.ac.uk Like what you hear? Please review, like, and share our podcast - and don't forget to subscribe to ensure you never miss an episode – and if you prefer to watch rather than listen, you'll find a video version of this podcast on our YouTube Channel and in Spotify: https://youtu.be/W8kj7PqHz98 This podcast is brought to you by University College London / UCLH NIHR Biomedical Research Centre in association with Alzheimer's Association, Alzheimer's Research UK, Alzheimer's Society and Race Against Dementia who we thank for their ongoing support.

This year's AD/PD Conference was held in Gothenburg, Sweden from the 28th March to 1st April. In this first of a two-part special we bring you highlights from the first three days of the conference. The AD/PD Conference focuses on basic science and translational and clinical research bringing New insights on disease mechanisms and etiologies, the latest findings from clinical trials, innovative outlooks on therapy and prevention and advances in diagnostic markers. In this special on-location recording our guest host Dr Nikoleta Daskoulidou, Research Associate from the UK Dementia Research Institute at Cardiff University talks with: Dr David J. Koss, Research Associate from Newcastle University. David is working to understand the molecular pathology which underpins a range of neurodegenerative dementias. Dr Susan Mitchell, Head of Policy at Alzheimer's Research UK. Susan is part of the ARUK policy and public affairs team, with responsibility for developing evidence-based policy to ensure people affected by dementia benefit from the progress in research. Elizabeth English, PhD Student at University of Cambridge. Lizzie, is utilising biophysical methods to characterise protein aggregates and their toxicity mechanisms in neurodegenerative disease. For more information on the event visit: https://adpd.kenes.com/ Full biographies on all our guests and a transcript can be found on our website: https://www.dementiaresearcher.nihr.ac.uk Like what you hear? Please review, like, and share our podcast - and don't forget to subscribe to ensure you never miss an episode – and if you prefer to watch rather than listen, you'll find a video version of this podcast on our YouTube Channel https://youtu.be/UQdm8aWuoFM This podcast is brought to you by University College London / UCLH NIHR Biomedical Research Centre in association with Alzheimer's Association, Alzheimer's Research UK, Alzheimer's Society and Race Against Dementia who we thank for their ongoing support.

Welcome to this episode of our podcast co-hosted by researchers Dr Gaia Brezzo and Mila Redzic, they our special guests sharing their inspiring story of resilience and hope. Today, we are joined by Denis and his daughter Maise, they became connected to Gaia and Mila after Denis experienced a life-altering event - a stroke. Together they share their personal journey of what it was like to have a stroke, the impact on the family, the challenges they faced during their recovery, and how they adapted to their new normal. They will also be sharing their journey of becoming involved in stroke research, the importance of research in stroke recovery, and how it has impacted their life. Through their story, we hope to shed light on the impact of stroke and the importance of research in advancing stroke care, its connections to dementia and the importance of improving the quality of life for stroke survivors. Please join us in welcoming our guest as they share their unique and inspiring journey. -- If you're interested in participating in a research study, and based in the UK, Join Dementia Research supports people of all ages, both with an without dementia to be matched with appropriate studies. Registration is free, and you can even register on behalf of someone who is unable to do so themselves. Visit https://www.joindementiaresearch.nihr.ac.uk if you live outside the UK, there may be a similar service in your region e.g. Trial Match in the USA, and Stepup For Dementia Research in Australia. -- Our hosts this week are: Dr Gaia Brezzo, Research Fellow in Cerebral Vascular Disease and Dementia at the UK Dementia Research Institute at The University of Edinburgh. Gaia's research focuses on understanding how immune alterations triggered by stroke shape chronic maladaptive neuroimmune responses that lead to post-stroke cognitive decline and vascular dementia. Mila Redzic, PhD Student at The University of Edinburgh. Mila is interested in understanding how microglial responses may shape changes occurring in the neurovascular unit in this context, and whether we can manipulate microglia to promote brain resilience and reduce cognitive impairment. -- Full biographies on the hosts and our guests, and a transcript can be found on our website https://www.dementiaresearcher.nihr.ac.uk -- Stroke is a serious medical condition that occurs when blood flow to the brain is interrupted, which can lead to brain damage. This damage can result in a range of cognitive problems, including dementia. Studies have shown that people who have had a stroke are at a higher risk of developing various forms of dementia, such as vascular dementia and Alzheimer's disease. The risk of dementia is particularly high in individuals who have had a stroke that affects a large part of the brain or who have had multiple strokes. In addition, many of the risk factors that increase the likelihood of having a stroke, such as high blood pressure, diabetes, and heart disease, also increase the risk of developing dementia. It's important to note that not everyone who has a stroke will develop dementia, and there are steps you can take to reduce your risk. Managing risk factors for stroke, such as maintaining a healthy diet and exercise routine, quitting smoking, and controlling blood pressure and cholesterol levels, can also help reduce the risk of dementia. -- Like what you hear? Please review, like, and share our podcast - and don't forget to subscribe to ensure you never miss an episode – and if you prefer to watch rather than listen, you'll find a video version of this podcast with full captions on our YouTube Channel – http://www.youtube.com/dementiaresearcher -- This podcast is brought to you by University College London / UCLH NIHR Biomedical Research Centre in association with Alzheimer's Association, Alzheimer's Research UK, Alzheimer's Society and Race Against Dementia who we thank for their ongoing support.

Last week we were in Aberdeen for the Alzheimer's Research UK Conference 2023 to hear the latest findings in dementia research. In the second of our two-part special we focus on sharing highlights from the main conference, which featured two days of brilliant scientific programming. Guest host Dr Zara Franklin from University of Aberdeen talks with Dr Natalie Connor-Robson from the UK Dementia Research Institute at Cardiff University, Dr Szu-Han Wang from The University of Edinburgh and Dr Steven Quinn from University of York. Full biographies on all our guests and a transcript can be found on our website: https://www.dementiaresearcher.nihr.ac.uk -- Like what you hear? Please review, like, and share our podcast - and don't forget to subscribe to ensure you never miss an episode – and if you prefer to watch rather than listen, you'll find a video version of this podcast with full captions on our YouTube Channel: https://www.youtube.com/dementiaresearcher -- This podcast is brought to you by University College London / UCLH NIHR Biomedical Research Centre in association with Alzheimer's Association, Alzheimer's Research UK, Alzheimer's Society and Race Against Dementia who we thank for their ongoing support.

Great progress has been made over the past decade in the development of blood based bio-markers to diagnose Alzheimer's disease and other forms of dementia. However, other areas have been quietly working away, and have also made significant progress. In this podcast we explore two of the newest and most innovative technologies being applied to detect biomarkers for dementia – looking at the retina and brainwaves. Dr Amanda Heslegrave, Senior Research Fellow at the UK Dementia Research Institute, University College London and one of the people behind the progress being made in blood-based biomarker field is out guest host. This weeks guests are: Dr Catherine Bornbaum, Head of Clinical Operations and Partnerships at Retispec. Catherine, uses innovative imaging technology combined with robust machine learning and artificial intelligence (AI) to detect biomarkers of neurodegenerative disease throughout the eye. The eye provides a simple and non-invasive way to measure the central nervous system; it is also the only organ where both neurons and blood vessels can be directly visualized at micron-level resolution. Dr George Stothart, Senior Lecturer at University of Bath. George is a cognitive neuroscientist who translates the findings of cognitive neuroscience into useful tools for clinicians and the wider world. His primary research focus is the development of a new EEG technique, known as Fastball, for the assessment of cognitive deficits in dementia. Fastball EEG is a completely passive test which measures brain waves the patient looks at a series of images on a computer screen over two minutes – a completely new assessment technique. -- For more information visit: https://www.retispec.com/ https://www.bath.ac.uk/projects/fastball-mci/ -- Full biographies on all our guests and a transcript can be found on our website https://www.dementiaresearcher.nihr.ac.uk -- Like what you hear? Please review, like, and share our podcast - and don't forget to subscribe to ensure you never miss an episode – and if you prefer to watch rather than listen, you'll find a video version of this podcast with full captions on our YouTube Channel – http://www.youtube.com/dementiaresearcher -- This podcast is brought to you by University College London / UCLH NIHR Biomedical Research Centre in association with Alzheimer's Association, Alzheimer's Research UK, Alzheimer's Society and Race Against Dementia who we thank for their ongoing support.

Dr. Axel Montagne is a chancellor's fellow and group leader at the UK Dementia Research Institute at the University of Edinburgh Centre for Clinical Brain Sciences. His group aims to understand how, when, and where critical components of the blood-brain barrier become dysfunctional preceding dementia and in the earliest stages of age-related cognitive decline. With this knowledge, they hope to develop precise treatments targeting brain vasculature to protect brain function. More importantly his work, and that of his colleagues, provide a critical lens through which to view the contributions of vascular dysfunction (or, conversely, vascular health – if we choose to preserve it) as a critical common thread in dementia and neurodegeneration. In this episode, we discuss: 11:44 - What dementias have in common 12:42 - The importance of preserving small blood vessels (in the brain) 13:38 - Changes in the blood-brain barrier in aging that cause "leaking" 15:11 - Predicting cognitive decline early with biomarkers – an opportunity for intervention? 16:32 - Why targeting amyloid isn't enough 18:54 - The impact of the APOE4 genotype on brain vasculature 24:19 - The cause of white matter damage in the brain 33:47 - Why the loss of omega-3 transport affects pericytes 35:25 - The role of exercise in prevention of blood-brain barrier dysfunction 35:45 - Why high heart rates during exercise preserve brain function 36:49 - The role of exercise in preserving vision health 40:17 - Why leaky vessels damage myelin and the brain 45:31 - Can you have more than one type of dementia? 47:54 - Does the breakdown of the blood-brain barrier cause “type 3 diabetes"? 54:03 - Why omega-3 may prevent detachment of pericytes 01:14:35 - Why a hepatitis drug restored cognition in APOE4 mice 01:19:39 - Why blood-brain barrier disruption results in the accumulation of amyloid-beta 01:25:14 - Why lifetime hypertension increases dementia risk 01:37:13 - Effects of obesity on blood-brain barrier leakage Watch this episode on YouTube Show notes are available by clicking here Join over 300,000 people and get the latest distilled information straight to your inbox weekly: https://www.foundmyfitness.com/newsletter Become a FoundMyFitness premium member to get access to exclusive episodes, emails, live Q+A's with Rhonda and more: https://www.foundmyfitness.com/premium Learn more about the premium podcast The Aliquot: https://www.foundmyfitness.com/aliquot

Over the past decade, blood-based biomarkers for dementia have been increasingly studied as way to diagnose and track the progress of Alzheimer's and other neurodegenerative diseases. In this podcast three leading blood-based biomarker pioneers come together to discuss the field, their research and motivations, current challenges and future directions of this field of research (they also reveal a little about themselves as people away from the lab too – find out which if them wants to drive refuse trucks…). In the host chair is Dr Nicholas Ashton, Associate Professor of Neurochemistry from University of Gothenburg and King's College London. Nicks has more than a decade of experience in biofluid analysis and assay development for Alzheimer's disease, which ranges from discovery mass spectrometry methods to ultra-sensitive immunoassays. Recently this has produced ultra-sensitive single molecular array (Simoa) assays for phosphorylated tau in blood, which are now widely used in research settings, therapeutics trials and being validated for clinical use. -- Nick's guests are: Oskar Hansson, Professor of Neurology & Senior Consultant in Neurology at Lund University in Sweden. Oskar explores fluid and imaging biomarkers for neurodegenerative disorders. His inspiration came at medical school when diagnosing dementias. It became clear to him that we needed to be able to identify these diseases before widespread neurodegeneration and disabling symptoms have already developed. At these early disease stages, we are more likely to substantially slow down or even stop the disease progression by different types of interventions. Henrik Zetterberg, Professor of Neurochemistry, Senior Consultant in Clinical Chemistry, Head of Department at UK Dementia Research Institute at University College London and University of Gothenburg. With a background in molecular biology and medicine, Henrik has have spent the last 15 years developing biomarkers for Alzheimer's disease and other brain disorders - becoming a world expert in the process. He has published more than 1100 scientific articles and has received numerous awards. -- If you're listening to this podcast, you probably already know that Biomarkers are proteins, molecules, or other measurable substances that can provide valuable insight into diagnosing and measuring the progression of a medical condition or disease. For a many years researchers have been exploring the potential of what can discover from blood, to help diagnose Alzheimer's and other Neurodegenerative diseases. -- You can find out more about our panellists, and their work on our website. There you will also find a full transcript: https://www.dementiaresearcher.nihr.ac.uk -- Like what you hear? Please review, like, and share our podcast - and don't forget to subscribe to ensure you never miss an episode. -- This podcast is brought to you by University College London / UCLH NIHR Biomedical Research Centre in association with Alzheimer's Association, Alzheimer's Research UK, Alzheimer's Society and Race Against Dementia who we thank for their ongoing support.

Professor John Hardy, group leader at the UK Dementia Research Institute at University College London & one of the world's foremost researchers into Alzheimer's disease on this breakthrough

Sarah Tabrizi is Director of the UCL Huntington's Disease (HD) Centre, Joint Head of Department Neurodegenerative Disease at the UCL Queen Square Institute of Neurology, a Principal Investigator at the UK Dementia Research Institute, and Honorary Consultant Neurologist at the National Hospital for Neurology and Neurosurgery. She graduated in Biochemistry, then studied Medicine at the University of Edinburgh where she was awarded the 1992 Leslie Gold Medal for the most distinguished medical graduate. Sarah undertook her PhD and trained as an independent scientist at UCL, establishing a large basic bench science and translational research team focussed on finding disease modifying therapies for HD. She was PI on the first successful phase 1/2b trial of an antisense oligonucleotide (NEJM 2019) and currently serves on several SABs advising industry on the development of potential gene targeting and nucleic acid therapies for HD. Sarah has published over 350 peer-reviewed research papers. In 2014 she was elected as a Fellow of the UK Academy of Medical Sciences. In 2017 she received the seventh Leslie Gehry Brenner Prize for Innovation in Science awarded by the Hereditary Disease Foundation. In 2018 she received the Cotzias Award from the Spanish Society of Neurology, and in 2019 the Yahr Award at the World Congress for Neurology and the Alexander Morison Medal from the Royal College of Physicians of Edinburgh. In 2022, she received the Osler Medal from the Association of Physicians of Great Britain and Ireland.

There's encouraging news about a potential treatment for Alzheimer's Disease following years of disappointing drug trials. The drug lecanemab is a monoclonal antibody which is designed to remove clumps of amyloid proteins which damage the brain. Professor Bart de Strooper who's director of the UK Dementia Research Institute explains how patients who had regular infusions of the drug had their rate of cognitive decline reduced by 27% when compared to those given a placebo. Sewage testing has been used around the world during the Covid pandemic – and at the moment children in London are being vaccinated against polio after the virus was found in waste water. The BBC's Health and Science Correspondent James Gallagher takes us on a tour of a sewer in southern England. Claudia Hammond's guest this week Professor Graham Easton from Queen Mary University of London looks at whether folic acid could reduce suicide and self harm – and whether it's ok to take anti-depressants during pregnancy. Presenter: Claudia Hammond Producer: Paula McGrath (Picture: Pharmaceutical research into brain disorders. Photo credit: Westend61/Getty Images.)

Each year 30 research scientists are paired with UK parliamentarians and civil servants. They learn about each other's work by spending time together in Westminster and the researcher's institutions. Those taking part gain an insight into how research findings can help inform policy making, and come away with a better understanding of how they can get involved. In this podcast we hear from three researchers who were part of the 2022 cohort - learning about their experience. Dr Fiona McLean from University of Dundee talks with Dr Dayne Beccano-Kelly from Cardiff University and Dr Sarah Marzi from Imperial College London, both group leaders within the UK Dementia Research Institute. For more information on the Royal Society Pairing Scheme visit: https://royalsociety.org/grants-schemes-awards/pairing-scheme/ You can find out more about our panellists, and their work on our website. There you will also find a full transcript: www.dementiaresearcher.nihr.ac.uk/podcast-…syndrome -- Like what you hear? Please review, like, and share our podcast - and don't forget to subscribe to ensure you never miss an episode. This podcast is brought to you in association with Alzheimer's Research UK and Alzheimer's Society, who we thank for their ongoing support.

This week Dr Fiona McLean from University of Dundee is with three colleagues all at the cutting edges of their fields to discuss their research, and the science behind vascular brain health, and what brain cells you'd really enjoy hanging out with on a night out in Glasgow! List to find out more… Maintaining a healthy brain is essential to having a healthy and long life. Brain health is increasingly talked about, but what does that really mean, and how does the vascular system play a role in that? Well, did you know that the health of your brain and your heart are connected? By keeping your heart and vascular system healthy, you also lower your risk for brain problems such as stroke and dementia… controlling blood pressure, eating health foods, and limiting alcohol, managing your risk of diabetes, not smoking and staying active and rested are important… this week our guests explore the science so don't worry if you don't know your extravascular cells from your endothelial cells, our great guests will explain (and if you do know, then you need to listen to discover our guests favourite cells, and which cells are which on a night out). This week's guests are: Dr Josie Fullerton, Postdoctoral Researcher at University of Glasgow studying extracellular vesicles, hypertension, stroke, heart & vascular disease & neuropathology. Dr Gaia Brezzo, Research Fellow in Cerebral Vascular Disease and Dementia at the UK Dementia Research Institute at The University of Edinburgh. Dr Sophie Quick, Post-doctoral researcher in the Centre for Regenerative Medicine, The University of Edinburgh researching neuroscience, specifically Cerebral Small Vessel Disease. -- You can find out more about our panellists, and their work on our website. There you will also find a full transcript: https://www.dementiaresearcher.nihr.ac.uk/podcast-vascular-brain-health-science/ -- Like what you hear? Please review, like, and share our podcast - and don't forget to subscribe to ensure you never miss an episode. This podcast is brought to you in association with Alzheimer's Research UK and Alzheimer's Society, who we thank for their ongoing support.

The largest genetic study of Alzheimer's to date has uncovered 42 more genes linked to the development of the disease. The new evidence has been hailed as crucial pieces to the puzzle to how the disease disrupts the brain's immune system, and can help in early detection. Around 70,000 New Zealanders suffer from dementia - with Alzheimer's the most common form. More than 700,000 people from around the world, including in New Zealand, had their genomes analysed in this study, which spanned across three decades. UK Dementia Research Institute spokesperson Dr Rebecca Sims was a co-lead of the study. She spoke to Corin Dann.

A special podcast recorded during last weeks AD/PD™ 2022, Alzheimer's & Parkinson's Diseases Conference in Barcelona (isn't it great to be back meeting face to face). Katy Hole, PhD Student from University of Bath guest hosts talking with four early researchers sharing their reflections on the week, and conference and science highlights. Guests are: Dr Amanda Heslegrave, Senior Research Fellow in the UK Dementia Research Institute at University College London. Dr Percy Griffin, Director of Scientific Engagement at Alzheimer's Association Wagner Brum, MD-PhD student from University of Gothenburg Anna Wernick, PhD Student at University College London _________________________ You can find out more about our panellists, and their work on our website. There you will also find a full transcript: https://www.dementiaresearcher.nihr.ac.uk/podcast-adpd-conference-highlights-2022 _________________________ Like what you hear? Please review, like, and share our podcast - and don't forget to subscribe to ensure you never miss an episode. This podcast is brought to you in association with Alzheimer's Research UK and Alzheimer's Society, who we thank for their ongoing support.

In this podcast Dr Mike Daniels, Postdoctoral Research Fellow in the UK Dementia Research Institute at The University of Edinburgh guests hosts a discussion with three researchers who know a great deal about Neurons – they discuss their research, lab life and mice challenges, the amyloid hypothesis, and the reproducibility. The healthy human brain contains tens of billions of neurons—specialized cells that process and transmit information via electrical and chemical signals. They send messages between different parts of the brain, and from the brain to the muscles and organs of the body. Alzheimer's disease disrupts this communication among neurons, resulting in loss of function and cell death. This weeks guests are: Dr Soraya Meftah, Postdoctoral Research Fellow in the UK Dementia Research Institute at The University of Edinburgh. Sorya explores the Neurophysiology of dementia (synaptic, neuronal, network dysfunction). Tabitha Broadbelt, PhD Student at The University of Edinburgh. Tabitha works in the field of Behavioural Neuroscience, Learning and Memory. Specifically looking at mechanisms of learning modulation in a mouse model of amyloid pathology. Jack Bray, PhD Student at University of Aberdeen. Jack is investigating EEG and behavioural abnormalities in preclinical mouse models of dementia (he also knows how to drive a ferry). You can find out more about our guests, and access a full transcript of this podcast on our website at: https://www.dementiaresearcher.nihr.ac.uk/podcast Register on our website to receive your weekly bulletin, and to access more great content – blogs, science, career support + much more https://www.dementiaresearcher.nihr.ac.uk This podcast is brought to you in association with Alzheimer's Research UK and Alzheimer's Society, who we thank for their ongoing support.