Podcasts about Porphyromonas

We're diving into the oral microbiome and how your mouth could be impacting both egg and sperm quality. Could what's happening in your mouth be impacting your fertility? In this episode, we dive into the surprising connection between your oral microbiome and reproductive health. From silent gum inflammation to the role of mouth breathing, you'll learn how your oral health can influence everything from egg quality and implantation to gut balance and sperm DNA. We're breaking down practical steps—like dental cleanings, gentle oral care, and smart toothpaste swaps—that can make a real difference on your fertility journey. If you're trying to conceive and looking for overlooked but powerful strategies, this one's for you. 

In this enlightening episode we welcome back the highly esteemed Rebecca Edwards, Director of Education at Activated Probiotics, to dive into the emerging and critical topic of the oral microbiome. The conversation covers the fundamental aspects of the oral microbiome, its significant links to brain health, Alzheimer's disease, cardiovascular issues, pregnancy outcomes, immune health, and even COVID-19 predispositions. Rebecca reveals the frightening realities of oral bacteria, including the pathways through which oral health can influence systemic conditions like Alzheimer's and rheumatoid arthritis. The podcast also emphasises practical actions for maintaining oral hygiene, the role of diet and hydration, and the groundbreaking potential of oral probiotics. Additionally, the episode provides a sneak peek into the upcoming Activated Probiotics Symposium, featuring a stellar lineup of speakers and groundbreaking topics aimed at shifting paradigms in healthcare.EPISODE HIGHLIGHTS:03:19 The importance of oral hygiene03:51 Understanding the oral microbiome06:45 The oral microbiome and public health09:05 The rise of microbiome interest post-COVID16:25 The oral microbiome's impact on brain health24:43 The role of dental plaque and gum disease29:49 Oral health and systemic diseases35:34 Call to action for practitioners38:19 The impact of COVID on healthcare39:28 Oral health and genetic predispositions41:29 The importance of dental care accessibility42:48 Rethinking mouthwash and bacteria45:26 Diet and oral microbiome48:02 Cardiovascular health and oral hygiene53:19 Probiotics for oral health59:13 Practical tips for oral hygiene01:03:04 Upcoming probiotic symposiumTickets to Activated Probiotics Symposium here:https://events.humanitix.com/activated-probiotics-symposium-2025Activated Probiotics instagram:https://www.instagram.com/activatedprobiotics/References to the oral microbiome:Kanagasingam S, von Ruhland C, Welbury R, Singhrao S K. Antimicrobial, polarizing light, and paired helical filament properties of fragmented tau peptides of selected putative gingipains. J Alzheimers Dis 2022; doi: 10.3233/JAD-220486.Kanagasingam S, von Ruhland C, Welbury R, Chukkapalli S S, Singhrao S K. Porphyromonas gingivalis conditioned medium induces amyloidogenic processing of the amyloid-β Protein precursor upon in vitro infection of SH-SY5Y cells. J Alzheimers Dis Rep 2022; doi: 10.3233/ADR-220029.Haditsch U, Roth T, Rodriguez L, Hancock S, Cecere T, Nguyen M, Arastu-Kapur S, Broce S, Raha D, Lynch CC, Holsinger LJ, Dominy SS, Ermini F. Alzheimer's Disease-Like Neurodegeneration in Porphyromonas gingivalis Infected Neurons with Persistent Expression of Active Gingipains. J Alzheimers Dis. 2020;75(4):1361-1376. doi: 10.3233/JAD-200393. PMID: 32390638; PMCID: PMC7369049.Stephen S. Dominy et al. ,Porphyromonas gingivalis in Alzheimer's disease brains: Evidence for disease causation and treatment with small-molecule inhibitors.Sci. Adv.5,eaau3333(2019).DOI:10.1126/sciadv.aau3333The Oral-Gut-Brain AXIS: The Influence of Microbes in Alzheimer's DiseaseNarengaowa1, Wei Kong1, Fei Lan1, Umer Farooq Awan2, Hong Qing1* and Junjun Ni1*References to all 11 studies on Biome BreatheRanjith, A., Nazimudeen, N. Bin, & Baiju, K. V. (2022). Probiotic mouthwash as an adjunct to mechanical therapy in the treatment of stage II periodontitis: A randomized controlled clinical trial. International Journal of Dental Hygiene, 20(2), 415–421. https://doi.org/10.1111/idh.12589Doppalapudi, R., Vundavalli, S., & Prabhat, M. (2020). Effect of probiotic bacteria on oral Candida in head‑ and neck‑radiotherapy patients: A randomized clinical trial. Journal of Cancer Research and Therapeutics, 6(3), 470–477. https://doi.org/10.4103/jcrt.JCRTThakkar, P. K., Imranulla, M., Kumar, P. G. N., Prashant, G. M., Sakeenabi, B., & Sushanth, V. H. (2013). Effect of probiotic mouthrinse on dental plaque accumulation: A randomized controlled trial. Dentistry and Medical Research|, 1(1), 7–12.Purunaik, S., Thippeswamy, H. M., & Chavan, S. S. (2014). To Evaluate the Effect of Probiotic Mouthrinse on Plaque and Gingivitis among 15-16 Year Old School Children of Mysore City, India- Randomized Controlled Trial. Global Journal of Medical Research, 14(4), 9–14.Jothika, M., Vanajassun, Pp., & Someshwar, B. (2015). Effectiveness of probiotic, chlorhexidine and fluoride mouthwash against Streptococcus mutans - randomised, single-blind, in-vivo study. Journal of International Society of Preventive and Community Dentistry, 5(7), 44. https://doi.org/10.4103/2231-0762.156153Jindal, G., Pandey, R. K., Agarwal, J., & Singh, M. (2011). A comparative evaluation of probiotics on salivary mutans streptococci counts in Indian children. European Archives of Paediatric Dentistry, 12(4), 211–215. https://doi.org/10.1007/BF03262809Manikandan, S., Behera, S., Karthikeyan, R., Niranjana, A., Bharathan, R., & Mohammed, O. B. (2020). Effect of green tea extract mouthrinse and probiotic mouthrinse on salivary pH in a group of schoolchildren: An in vivo study. Journal of Pharmacy And Bioallied Sciences, 12(5), 404. https://doi.org/10.4103/jpbs.JPBS_119_20Jindal, V., Mahajan, N., Goel, A., Kaur, R., Mahajan, A., & Malhotra, P. (2017). Clinical efficacy of probiotic mouthwash in the treatment of gingivitis patients in Himachal population. Journal of the International Clinical Dental Research Organization, 9(1), 41. https://doi.org/10.4103/2231-0754.207386Deshmukh, M. A., Dodamani, A. S., Karibasappa, G., Khairnar, M. R., Naik, R. G., & Jadhav, H. C. (2017). Comparative evaluation of the efficacy of probiotic, herbal and chlorhexidine mouthwash on gingival health: A randomized clinical trial. Journal of Clinical and Diagnostic Research, 11(3), ZC13–ZC16. https://doi.org/10.7860/JCDR/2017/23891.9462Sharma, P., Datta, G., Gandhi, K., & Kumar, D. (2019). A comparative evaluation of efficacy of probiotic and chlorhexidine mouthrinses on gingival health and plaque accumulation in 6-9 year old children. International Journal of Applied Dental Sciences, 5(1), 156–162. http://www.oraljournal.com/archives/2019/5/1/C/5-1-43Doppalapudi, R., Vundavalli, S., & Prabhat, M. P. V. (2020). Effect of probiotic bacteria on oral Candida in head‑ and neck‑radiotherapy patients: A randomized clinical trial. Journal of Cancer Research and Therapeutics, 16, 470–477. https://doi.org/10.4103/jcrt.JCRT

Dental Detoxification, the Oral Microbiome, and Our Health with Dr. Sanda Moldovan  In this episode of the RWS Clinician's Corner, Margaret Floyd Barry interviews biological periodontist and nutritionist Dr. Sanda Moldovan.    They discuss:    The connection between oral health and systemic health, including the connection between the oral microbiome and diseases such as heart attacks, cancer and Alzheimer's  Considerations and strategies for testing the oral microbiome The health implications of bleeding gums and bacterial migration Strategies for full mouth detoxification How to mitigate receding gums  How nutrition professionals can support their clients before, during, and after dental procedures such as surgeries and the removal of mercury amalgams  How to find a qualified biological dentist Preventative measures for cavities and the role of pH balance in tooth health The Clinician's Corner is brought to you by Restorative Wellness Solutions.  Follow us: https://www.instagram.com/restorativewellnesssolutions/  Timestamps:  00:00 Dental school led to serious mercury toxicity issues. 09:50 Fusobacterium linked to gut disease and tumors. 15:02 Focus: Eleven microbes and Il-6 marker testing. 16:13 Three-step dental hygiene reduces periodontal issues. 23:31 Removal of infected tooth improved digestion, palpitations. 26:08 Full mouth health crucial; traditional dentistry overlooked this. 36:08 Recommendations for natural, effective teeth whitening? 39:12 Early diet affects jaw development and airway health. 44:19 Podcast promotes clinical training for health practitioners. 51:04 Teeth can remineralize enamel using calcium hydroxyapatite. 55:10 Fotona laser treats sleep apnea more effectively. 01:00:26 Brush gums with recession; collagen supplements help. 01:06:13 Join, follow, review, share, email topic requests Speaker bio:  Dr. Sanda Moldovan is a distinguished periodontist and nutritionist, renowned for pioneering approaches in natural oral health and wellness. She's the owner of Beverly Hills Health and Dental Wellness, she also founded Orasana, an oral health product line. An advocate for microbiome testing and nutritional therapeutics in dentistry, Dr. Sanda educates professionals and the public alike. A popular speaker and media personality, she hosts "The Holistic Dentistry Show Podcast" and authored: Heal Up!: Seven Ways to Faster Healing and Optimum Health, promoting holistic wellness.   Connect with Dr Sanda:  https://orasana.com/  https://www.drsandamoldovan.com/  https://www.beverlyhillsdentalhealth.com/   https://www.youtube.com/user/AskDrSanda  https://podcasts.apple.com/gb/podcast/holistic-dentistry-show-with-dr-sanda/id1680386392 https://www.instagram.com/drsanda/  https://www.linkedin.com/in/dr-sanda-moldovan-2b601b35/ Keywords:  Sleep apnea diagnosis, CPAP machines, dental appliances, Fotona laser, TMJ treatment, TMD treatment, Botox for TMJ, peptide injections, red light therapy, blue light safety, gum recession, collagen supplementation, gum grafting, functional medicine, mercury toxicity, oral microbiome, cardiovascular disease, neurodegenerative diseases, adverse pregnancy outcomes, systemic health, Actinomyces, Porphyromonas gingivalis, leaky gums, microbiome testing, cone beam CT scan, root canal alternatives, BPA-free fillings, remineralization of teeth, sleep and oral health, holistic dentistry Disclaimer: The views expressed in the RWS Clinician's Corner series are those of the individual speakers and interviewees, and do not necessarily reflect the views of Restorative Wellness Solutions, LLC. Restorative Wellness Solutions, LLC does not specifically endorse or approve of any of the information or opinions expressed in the RWS Clinician's Corner series. The information and opinions expressed in the RWS Clinician's Corner series are for educational purposes only and should not be construed as medical advice. If you have any medical concerns, please consult with a qualified healthcare professional. Restorative Wellness Solutions, LLC is not liable for any damages or injuries that may result from the use of the information or opinions expressed in the RWS Clinician's Corner series. By viewing or listening to this information, you agree to hold Restorative Wellness Solutions, LLC harmless from any and all claims, demands, and causes of action arising out of or in connection with your participation. Thank you for your understanding.  

Order 'Build, Don't Talk' (in English) here: ⁠⁠⁠⁠https://amzn.eu/d/eCfijRu⁠⁠⁠⁠ Order 'Build Don't Talk' (in Hindi) here: ⁠⁠⁠⁠https://amzn.eu/d/4wZISO0⁠⁠⁠⁠ Disclaimer: This episode is intended solely for educational purposes and opinions shared by the guest are his personal views. We do not seek to defame or harm any person/brand/product mentioned in the episode. Our goal is to provide information to help audience make informed choices.

In this episode, our guest is Jonathan Dornell, the co-host of the Let's Get Oral podcast. We explore the oral microbiome and how to understand and nurture this vital ecosystem to optimize your brain and body health. You'll learn about key topics like: nitric oxide, neurogastronomy, and how simple habits - like chewing mindfully, eating a balanced diet, and avoiding mouthwash and teeth whitening - can protect your oral microbiome, possibly reducing risks for conditions like caries (cavities), dementia, and heart disease.We also discuss the relationship between bacteria and humans, smell and taste perception, the benefits of slowing down, and the role of prebiotics, probiotics, and postbiotics, as well as how sugar and sweet flavors influence our oral and overall health. RESOURCESBACTERIA - Candida albicans- Lactobacillus - Prevotella- Prevotella intermedia- Porphyromonas gingivalis- Rothia- Streptococcus mutans - Treponema denticola - Veillonella- Veillonella dispar- Veillonella parvula BOOKS- If Your Mouth Could Talk by Kami HossORGANIZATIONS- American Academy for Oral Systemic Health (AAOSH)- The Integrative Dental Medicine Scholar SocietyOTHER VOCAB- Amylase- Arginine- Biofilm- Commensal- Culturomics- Electron micrograph- Lozenge- Neurogastronomy- Nitrates- Periopathogen - Periodontitis- Retronasal smell- Supertaster- XylitolPAPERS- Did the Brain and Oral Microbiota Talk to Each Other? A Review of the Literature- The Oral-Microbiome-Brain Axis and Neuropsychiatric Disorders: An Anthropological Perspective**CONNECT & LEARN MORE**website: letsgetoral.compodcast: Let's Get OralIG: @letsgetoralLinkedIn: /jddornell

Howdy, listeners! Grandpa Bill here, back on the BH Sales Kennel Kelp Holistic Healing Hour, and today we're diving into a fascinating topic: the connection between gum disease and Alzheimer's disease. Recent studies have shed light on a potential link, and it all boils down to some nasty bacteria called Porphyromonas gingivalis. This little bugger doesn't just cause gum problems – it might be sneaking into your brain too! The Gum-Brain Connection Let's break it down. Think of your brain as a high-security vault. The blood-brain barrier acts as the guard, keeping out anything harmful. But when you have gum disease, chronic inflammation can weaken this barrier. This leaky barrier might allow Porphyromonas gingivalis and its inflammatory pals to enter the brain, potentially contributing to Alzheimer's development. Silent Threat: Here's the kicker – gum disease often progresses silently, with many folks not noticing symptoms until the disease is advanced. That's why regular dental checkups and good oral hygiene are so crucial. Taking Control The good news? We have the power to fight back! Here are some natural steps you can take: Have you ever experienced gum disease? What steps did you take to address it?Knowing the potential link to Alzheimer's, are there any changes you'd consider making to your oral hygiene routine?

In this episode of The Autoimmune RESET,  VJ explores the intricate connections between rheumatoid arthritis (RA), gut health, and dental health. VJ begins by delving into the fundamentals of RA, including its diagnosis and underlying causes, emphasising the role of genetics, environment, and immune dysregulation in disease development.Next, VJ examines the emerging evidence linking gut dysbiosis to RA, highlighting key bacteria such as Prevotella copri and Faecalibacterium prausnitzii that may influence disease progression. Similarly, VJ explores the potential impact of periodontal disease bacteria, particularly Porphyromonas gingivalis, on RA pathogenesis, underscoring the importance of oral hygiene in RA management.Throughout the episode, VJ discusses practical strategies to support gut and dental health in those with RA, including dietary interventions, probiotics, oral hygiene practices, and stress management techniques. By adopting a holistic approach that addresses the interconnected aspects of RA, you can empower yourself to manage symptoms better, improve overall well-being, and enhance your quality of life.You can watch Nutrition Essentials for Joint Health here. You can download your free copy of The Autoimmune RESET here.And you can access all of VJ's free resources here.If you would like to book a free initial consultation with VJ Hamilton, The Autoimmunity Nutritionist, to find out how nutritional therapy and functional medicine could improve your health, you can book an appointment here.Learn more about the functional medicine services at The Autoimmunity Nutritionist Clinic here.Thanks for listening! You can join The Autoimmune Forum on Facebook or find me on Instagram @theautoimmunitynutritionist.

Heather the Hygienist is a certified biological dental hygienist and a certified registered dental hygienist for 25 years. She grew up on a farm in Minnesota and Wisconsin but moved to Florida in the '80s.  It wasn't until 2010, however, that Heather started to look into the chemicals in commercial products. On a mission to provide patients with the cleanest, most effective oral care products on the market, Heather created Simply Silver Mouthwash, Toothpaste, and Breath Spray. Topics: 1. Root Causes of Periodontal Disease: Oral Microbiome: Periodontal disease often starts with an imbalance in the oral microbiome. Harmful bacteria, such as Porphyromonas gingivalis, can lead to plaque build-up and inflammation in the gums. Poor Oral Hygiene: Inadequate oral hygiene practices, including infrequent brushing and flossing, can contribute to the accumulation of plaque and the progression of gum disease. 2. Connection Between Oral and Gut Microbiomes: Oral-Gut Axis: There is growing evidence of a bidirectional relationship between the oral and gut microbiomes, known as the oral-gut axis. Changes in one microbiome can affect the other. Inflammatory Response: Gum disease can lead to chronic inflammation in the mouth, which may contribute to systemic inflammation. This inflammation could impact the gut microbiome and overall gut health. 3. Treatment and Prevention: Oral Care: Maintaining good oral hygiene practices is crucial for preventing and managing gum disease.4. Signs of Gum Disease: Gingivitis: Early signs include red, swollen gums and bleeding when brushing or flossing. Periodontitis: Advanced gum disease can lead to receding gums, pockets between teeth and gums, and even tooth loss. It may also be associated with chronic bad breath. 5. Importance of Regular Dental Check-ups: Routine dental check-ups are essential for early detection and management of gum disease. 6. Role of Mouthwash Products: Simply Silver Mouthwash products may contain colloidal silver, which is believed to have antibacterial properties. Some people use colloidal silver mouthwash to help control harmful bacteria in the mouth. Commercial Mouthwash: While some mouthwash products may be beneficial, it's important to use them with caution. Commercial mouthwashes often contain alcohol and other ingredients that can have adverse effects on the oral microbiome.7. Mouthwash: Alcohol-Free Options: If you decide to use a mouthwash, consider alcohol-free options.Balanced Approach: While mouthwash can be a part of oral care, it should not replace essential practices like regular brushing, flossing, and dental check-ups.LINKS TO OTHER SPEAKER RELATED INFORMATIONwww.simplysilvermouthwash.com https://www.instagram.com/simplysilvermouthwash/ https://www.tiktok.com/@heatherthehygienist1Author: The Holistic Health ShowGuest Speaker: Heather the Hygienist Category: Health and WellnessPublish date: 2024-03-19Duration: [00:31:40]Transcript www.bodymindki.com/podcastSupport the showThanks for listening! SUBSCRIBE to The Holistic Health Show today and embark on a transformative journey towards a more harmonious and balanced life.Follow us on Facebook, Instagram and YouTube!

Cześć, nazywam się Mariusz Gogól i zapraszam Cię do posłuchania podcastu z cyklu “Wokół Życia”. Tematem dzisiejszego odcinka są podobieństwa i różnice między komórkami ludzi i bakterii. Jakie mamy podobieństwa biochemiczne? Czym się różnimy? Czy te podobieństwa i różnice możemy w jakiś sposób wykorzystać? To tylko niektóre pytania, na które będę szukał odpowiedzi w rozmowie z naszym ekspertem - dr. Mariuszem Madejem z Zakładu Mikrobiologii WBBiB UJ. W trakcie rozmowy porozmawiamy na temat ekspresji genów w mikroorganizmach, edycji genów metodą CRISPR/Cas oraz o antybiotykach. Poruszymy także temat zmienności bakterii. Czy ją także możemy jakoś wykorzystać? Dr Mariusz Madej w pracy badawczej interesuje się biologią strukturalną bakteryjnych białek błonowych, a jako modelowy organizm bada bakterię Porphyromonas gingivalis – główną bakterię odpowiedzialną za rozwój paradontozy. Dr Mariusz Gogól – biolog, biochemik, edukator i popularyzator nauki. Więcej o jego działaniach dowiesz się z profilu na Instagramie: https://www.instagram.com/drmariuszgogol Dofinansowano ze środków Ministerstwa Edukacji i Nauki z programu Społeczna Odpowiedzialność Nauki w ramach projektu „Nauka na żywo: wszechświat, życie, umysł". Kwota dofinansowania 540 200,00 zł, całkowita wartość zadania 600 200 zł.

BB68S significantly improved subjects' cognitive functions (total RBANS score increased by 18.89 points after intervention, p less than 0.0001), especially immediate memory, visuospatial/constructional, attention, and delayed memory domains. BB68S intervention increased the relative abundances of beneficial bacteria Lachnospira, Bifidobacterium, Dorea, and Cellulosilyticum, while decreasing those of bacteria related to cognition impairment, such as Collinsella, Parabacteroides, Tyzzerella, Bilophila, unclassified_c_Negativicutes, Epulopiscium, Porphyromonas, and Granulicatella. #BifidobacteriumlongumBB68S #memory #probiotic Shi, S.; Zhang, Q.; Sang, Y.; Ge, S.; Wang, Q.; Wang, R.; He, J. Probiotic Bifidobacterium longum BB68S Improves Cognitive Functions in Healthy Older Adults: A Randomized, Double-Blind, Placebo-Controlled Trial. Nutrients 2023, 15, 51. https://doi.org/10.3390/nu15010051 Bifidobacterium longum BB68S, RBANS, Cognition, immediate memory, visuospatial, attention, delayed memory, Repeatable Battery for the Assessment of Neuropsychological Status, human enhancement, memory enhancement, probiotic intervention, microbiota, Cognitive Functions --- Support this podcast: https://anchor.fm/ralph-turchiano/support

Bifidobacterium longum BB68S Cognition Enhancement Super Star Episode #1116 DEC 2022 BB68S significantly improved subjects' cognitive functions (total RBANS score increased by 18.89 points after intervention, p less than 0.0001), especially immediate memory, visuospatial/constructional, attention, and delayed memory domains. BB68S intervention increased the relative abundances of beneficial bacteria Lachnospira, Bifidobacterium, Dorea, and Cellulosilyticum, while decreasing those of bacteria related to cognition impairment, such as Collinsella, Parabacteroides, Tyzzerella, Bilophila, unclassified_c_Negativicutes, Epulopiscium, Porphyromonas, and Granulicatella. #BifidobacteriumlongumBB68S #memory #probiotic Shi, S.; Zhang, Q.; Sang, Y.; Ge, S.; Wang, Q.; Wang, R.; He, J. Probiotic Bifidobacterium longum BB68S Improves Cognitive Functions in Healthy Older Adults: A Randomized, Double-Blind, Placebo-Controlled Trial. Nutrients 2023, 15, 51. https://doi.org/10.3390/nu15010051 Bifidobacterium longum BB68S, RBANS, Cognition, immediate memory, visuospatial, attention, delayed memory, Repeatable Battery for the Assessment of Neuropsychological Status, human enhancement, memory enhancement, probiotic intervention, microbiota, Cognitive Functions --- Support this podcast: https://anchor.fm/ralph-turchiano/support

In this episode of Defiant Health, I interview Oklahoma dentist, health and wellness coach, and advocate of managing the oral microbiome, Dr. Debbie Ozment. I met Dr. Ozment during one of my two-way weekly video meetups on my DrDavisInfiniteHealth.com where she provided a presentation on the oral microbiome. I was impressed with her tremendous command of this area that drives home the message that oral health and the oral microbiome are major determinants of overall health. She discusses, for instance, how the oral microbe Porphyromonas gingivalis plays a role in Alzheimer's dementia, and Fusobacterium from the gums is proving to be a major cause for colon cancer---all factors you are able to address. I believe you will find Dr. Ozment's interview informative and enlightening.About Dr. OzmentA graduate of Oklahoma University College of Dentistry, she served as adjunct faculty there for seven years. Dr. Ozment completed a Masters' degree in Metabolic and Nutritional Medicine from the University of South Florida Morsani College of Medicine and is a Diplomate with the American Academy of Anti-Aging Medicine. Trained at Mayo Clinic, she is a Nationally Board Certified Health and Wellness Coach.Dr. Ozment's websiteDr. Ozment's TED TalkVitality Made Simple Podcast on Apple PodcastsGUM Picks______________________________________________________________________________________Get your Paleovalley discount on fermented grass-fed beef sticks, Bone Broth Collagen, and low-carb snack bars:Use the coupon code "Defiant" for an additional 15% discount. Go to this page on the Paleovalley website, enter the code and the discount will be automatically applied to your order.They are currently offering a 12% discount that continues for life for their Wild Pastures grass-fed, grass-finished beef and pastured chicken and pork! Go herefor more information.______________________________________________________________________________________For more information on Dr. Davis' programs:Books:Super Gut: The 4-Week Plan to Reprogram Your Microbiome, Restore Health, and Lose WeightWheat Belly: Lose the Wheat, Lose the Weight and Find Your Path Back to Health; revised & expanded editionWheat Belly 10-Day Grain DetoxWheat Belly 30-Minute (Or Less!) CookbookUndoctored: Why Health Care Has Failed You and How You Can Become Smarter Than Your DoctorOnline media:Dr. Davis' Infinite Health Blog: www.DrDavisInfiniteHea

Are amalgam fillings really safe? Do antibacterial mouthwash and fluoride-based toothpaste live up to their claims? What about Waterpiks and flossing up into the gumline?Is it possible that these conventional approaches to oral health create more problems?The relationship between your gut and oral microbiome is profound, so it stands to reason that it's important to investigate the role poor diet, gut infections, and nutrient deficiencies play in gum disease and overall health.So today, I'm talking with Dr. Al Danenberg about what conventional dentistry doesn't consider when it comes to treating and preventing gum disease and how we can best care for our oral health.Dr. Al Danenberg goes by “Dr. Al”. He is a periodontist and was in private practice for 44 years. He incorporated ancestral nutrition & lifestyle with his leading-edge laser protocol to treat periodontal disease. Currently, Dr. Al consults with patients all over the world regarding animal-based nutrition, lifestyle, oral & overall health, and the importance of a healthy gut and immune system. Content warning: Brief, non-graphic mention of verbal and sexual abuse.Listen to the full episode to hear:How conventional dentistry treats symptoms of oral health issues but doesn't address root causesThe three main functions of healthy dental plaqueThe relationship between gum disease, gut dysbiosis, and chronic inflammationHow to gently and effectively care for your teeth, gums, and tongueLearn more about Al Danenberg, DDS:DrDanenberg.comInstagram: @dr.danenbergFacebook: @draldanenbergLearn more about Sami:Eatfor.lifeBook Your Complimentary ConsultationEat For Life cookbooks for each unique biotypeResources:Revitin ToothpasteStress & the gut-brain axis: Regulation by the microbiome - ScienceDirectCancer mortality among Brazilian dentists - Koifman - 2014 - American Journal of Industrial Medicine - Wiley Online LibraryLife Below the Gum Line: Pathogenic Mechanisms of Porphyromonas gingivalis | Microbiology and Molecular Biology ReviewsImmediate Effects of Laser-Assisted New Attachment Procedure (LANAP) on Human Periodontitis MicrobiotaStress gets into the belly: Early life stress and the gut microbiome - ScienceDirect

Researchers from the University of Louisville School of Dentistry and their colleagues have discovered details of how proteins produced by oral epithelial cells protect humans against viruses entering the body through the mouth. They also found that oral bacteria can suppress the activity of these cells, increasing vulnerability to infection.A family of proteins known as interferon lambdas produced by epithelial cells in the mouth serve to protect humans from viral infection, but the oral bacteria Porphyromonas gingivalis reduces the production and effectiveness of those important frontline defenders.Dr. Juhi Bagaitkar and Dr. Richard Lamont, professor and chair of the UofL Department of Oral Immunology and Infectious Disease, led the work, with first author Carlos J. Rodriguez-Hernandez and other colleagues at UofL and at Washington University in St. Louis. The findings were published in December in PNAS.

Welcome, Dr. Tom to Hunger Hunt Feast! Tom is the first dentist in the US to apply DNA-PCR technology to all of his patients in the treatment of oral infections, he is the founder of Oral DNA Labs: sold to Quest Diagnostics and Chief Dental Officer for Quest Diagnostics. Listen in as Zane and Dr. Tom talk about how the bacteria in your mouth can cause heart disease. This insightful conversation is the perfect episode for anyone who wants to take their overall health to the next level. QUICK NOTES FROM ZANE: Oral bacteria can cause systemic inflammation in the rest of the body Oral bacteria can embed themselves in endothelial lining of the arteries beginning the process of heart disease, atherosclerosis You can have a healthy diet and exercise routine and still develop heart disease from the bacteria These bacteria can also cause cancer. Periodontal bacteria associated with metabolic disease and type 2 diabetes. Genetic testing on the bacteria to determine the level of pathogenic bacteria population. There are specific antiseptics used to reduce the bacterial pathogens that most dentists are not using   LINKS: https://www.aaosh.org For periodontal bacteria testing and treatment in Nashville, TN https://www.thomasnabors.com/ Periodontal Diseases and Carotid Intima-Media Thickness in Bangladesh https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5063685 Treatment of periodontal disease results in improvements in endothelial dysfunction and reduction of the carotid intima-media thickness https://pubmed.ncbi.nlm.nih.gov/19074511/ Dental prophylaxis and periodontal treatment are protective factors to ischemic stroke https://pubmed.ncbi.nlm.nih.gov/23422085 Periodontal Infection, Systemic Inflammation, and Insulin Resistance https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3476901/ Periodontitis induced by Porphyromonas gingivalis drives periodontal microbiota dysbiosis and insulin resistance via an impaired adaptive immune response https://pubmed.ncbi.nlm.nih.gov/26838600/ Periodontal Bacteria and Prediabetes Prevalence in ORIGINS: The Oral Infections, Glucose Intolerance, and Insulin Resistance Study https://pubmed.ncbi.nlm.nih.gov/26082387/ Periodontal Disease and Incident Lung Cancer Risk: A Meta-Analysis of Cohort Studies https://pubmed.ncbi.nlm.nih.gov/27294431/ Severity of Periodontitis and Metabolic Syndrome: Is There an Association? https://pubmed.ncbi.nlm.nih.gov/26654349/ Association of apical periodontitis and type 2 diabetes https://jada.ada.org/article/S0002-8177(21)00037-4/fulltext   Questions? You can email your questions to zane@zanegriggs.com. Connect with me at zanegriggs.com or on Instagram @zanegriggsfitness   QUICK EPISODE SUMMARY Meet Dr. Tom A short recap of Dr. Tom's medical career The importance of your mouth for overall health  How inflammation is the first warning sigh The organisms that create inflammation  What every dentist should be doing for their patients  Why Dr. Tom decided to get fit in his 70s When Dr. Tom''s son had medical complications  Know the data on your mouth The main role of every dentist  When Dr. Tom spoke at Harvard  Why the dentistry model must change

George T. Grossberg, MD, conducts a Masterclass examining emerging treatment options for Alzheimer’s disease that are tied to the new research on the microbiome. Dr. Grossberg is the Samuel W. Fordyce professor and director of geriatric psychiatry in the department of psychiatry and behavioral neuroscience at Saint Louis University. He disclosed that he is a consultant for Acadia, Alkahest, Avanir, Axovant, Axsome Therapeutics, Biogen, BioXcel, Genentech, Karuna, Lundbeck, Novartis, Otsuka, Roche, and Takeda; receives research support from the National Institute on Aging, Janssen, and Genentech/Roche; performs safety monitoring for ANAVEX, EryDel, Intra-Cellular Therapies, Merck, and Newron; and serves on the data monitoring committee of ITI Therapeutics. Dr. Grossberg also serves on the speakers’ bureau of Acadia. Take-home points Dr. Grossberg discusses burgeoning research about treatment of Alzheimer’s disease (AD) by altering the microbiota using diet and medications. The microbiome refers to the entirety of microorganisms that live throughout the body. Microbiota are those organisms that live within the gut. Dysbiosis refers to a microbial imbalance, which has been linked to numerous disorders, including inflammatory diseases, psychiatric illness, obesity, diabetes, and more recently, AD. The gut-brain axis describes the impact of microbiota and GI tract health on the brain. Periodontal disease, as a marker of inflammation and as part of the microbiome, is linked to AD. Increasing research into the role of the microbiome, inflammation, and AD has revealed promising treatments. Sodium oligomannate, a drug approved for mild to moderate AD in China, has been shown to slow the progression of AD by remodeling the microbiota and suppressing the production of specific amino acids that promote neuroinflammation. Summary The microbiota has many purposes, including digestion, communication with the immune system, generation of signaling peptides, refining vitamins, and producing antioxidants. Many factors influence the microbiome, including diet, use of antibiotics, exposure to breast milk as an infant, stress, and old age. The gut microbiota can be altered by consuming “prebiotics,” which are food sources that influence the composition of the microbiota. These foods include fermented foods such as yogurt, kombucha, sauerkraut, and kimchi. The Mediterranean diet also has good sources of prebiotics. Birthing method (C-section versus vaginal birth) also influences the microbiota; a recent study shows that an infant’s microbiota after C-section can be altered by giving them an early fecal transplantation from the mother. As further proof of the link between periodontal disease and AD, a recent study identified the presence of Porphyromonas gingivalis, a bacteria that causes gum disease, in the brain in close proximity to the tau tangles of AD. Gingipain, the toxin secreted by this bacteria, is found in high concentrations in brains of individuals with AD. Dr. Grossberg reviewed his “recipe” for AD prevention and treatment: Recommend adequate activity in four spheres: Physical, mental, social, and spiritual. Treat and control all cardiovascular risk factors, including smoking, obesity, diabetes, hypertension, and hyperlipidemia. Recommend good oral hygiene based on the increasing research about the link of periodontal disease and AD. Recommend dietary changes, including a prebiotic or probiotic, and the Mediterranean diet. Dietary changes may also include supplements such as curcumin, B-complex multivitamin, and vitamin E. Control exposure to air pollution as possible. Use a combination pharmacotherapy of an N-methyl-D-aspartate antagonist and a cholinesterase inhibitor for individuals with AD. References Jones ML et al. Gut Microbes. 2014 Jul 1;5(4):446-57. Askarova S et al. Front Cell Infect Microbiol. 2020;10:104. Beydoun MA et al. J Alzheimers Dis. 2020;75(1):157-72. Wang X et al. Cell Res. 2019 Oct;29(10):787-803. Korpela K et al. Cell. 2020 Oct 15;183(2):324-34. *  *  * Show notes by Jacqueline Posada, MD, associate producer of the Psychcast; assistant clinical professor in the department of psychiatry and behavioral sciences at George Washington University, Washington; and staff physician at George Washington Medical Faculty Associates, also in Washington. Dr. Posada has no conflicts of interest. For more MDedge Podcasts, go to mdedge.com/podcasts Email the show: podcasts@mdedge.com

Gary takes on the real issues that the mainstream media is afraid to tackle. Tune in to find out the latest about health news, healing, politics, and the economy. Study shows that mindfulness can help ease the pain of breast cancer survivors University of Ottawa (Canada), January 6, 2021 A study led by University of Ottawa researchers provides empirical evidence that mindfulness has a significant impact on the brain of women suffering from neuropathic pain related to breast cancer treatment. The researchers showed that mindfulness-based stress reduction (MBSR) helps modulate neuropathic pain. Their findings could make a difference in the lives of many women. In Canada, over a quarter of a million women are expected to be diagnosed with breast cancer - the most diagnosed cancer among women worldwide - in 2020. In addition to the psychological impacts of breast cancer, approximately 20 to 50 percent of survivors report experiencing chronic neuropathic pain following treatment. We talked to senior author Dr. Andra Smith, Full Professor at the uOttawa School of Psychology, to learn more about the most recent findings published in the journal Mindfulness. Why did you and your team decide to look at mindfulness to improve pain-related problems? "Neuropathic pain is a very common side effect of chemotherapy and other breast cancer treatments. Pain killers do not always work and quality of life, cognitive abilities, and overall well-being can be reduced due to this pain. Due to these negative effects and the complexity of treatment for this type of pain following breast cancer treatment, it is important to provide adjunct treatment and management options. We have heard a lot about mindfulness over the past few years, about how it helps people relax and feel better. If mindfulness, a non-pharmacological tool, can be used to help with neuropathic pain, women will feel better and might not experience such disruptive pain. Pain is a subjective experience and mindfulness is often dismissed as a "buzz word." But our research provides objective, empirical evidence of a significant impact of mindfulness on the brain of these women." How was the research conducted? "We investigated the impact of an 8-week mindfulness-based stress reduction (MBSR) program on emotional reactivity among a sample of breast cancer survivors with chronic neuropathic pain. We used state-of-the-art brain imaging at The Ottawa Hospital, on their 3T MRI scanner and collected data on white matter health, brain activity during emotional pain related word processing and during resting state. Women with neuropathic pain were imaged before and after an MBSR program, or treatment as usual. Pain, quality of life, and imaging were compared between the two groups and within the MBSR group pre- and post-MBSR." What did you find? "We observed major reductions in brain activity following mindfulness-based stress reduction in regions related to pain, emotional regulation, and cognitive processing. Both pain severity and pain interference, for the MBSR group, were significantly reduced after the 8-week training. Our results show a significant improvement in brain health as well as in pain perception. There are many anecdotal reports of how this or that made a person "feel better" but the really exciting results here are that we can see that there are actual changes in the brain and the way a person can alter their response to pain." Why is it important? "This research provides hope for a non-invasive method of easing the struggle of chronic neuropathic pain in women following breast cancer treatment. Pain is something that people fear, and many people run into significant secondary problems because of their pain medication use, including drug misuse and mental health issues. Mindfulness has a neurophysiological effect that can alter one's perception of pain. This research shows that there are adjunctive treatment options. If used properly, the information we have published can improve health outcomes for the people involved and could potentially also reduce health costs, as well as some of the related problems - particularly those related to mental health." Who worked on this research? "Dr. Patricia Poulin, at The Ottawa Hospital, was the clinical principal investigator with her research team of Heather Romanow, Yaad Shergill, Emily Tennant, and Eve-Ling Khoo. This included recruitment of the women and all clinical assessments. My lab performed the scanning component of the study, including my imaging team of Dr. Taylor Hatchard, Ola Mioduszewski and Dr. Lydia Fang. The data was collected over two years, from 2017 to 2019, funded by both Canadian Institutes of Health Research (CIHR) and Canadian Breast Cancer Foundation grants. We published three articles on our research in the last four months. The latest, "Reduced Emotional Reactivity in Breast Cancer Survivors with Chronic Neuropathic Pain Following Mindfulness-Based Stress Reduction (MBSR): an fMRI Pilot Investigation" was published in November 2020 in the journal Mindfulness." Moderate calcium intake, supplementation associated with reduced mortality risk during up to two decades of follow-up University of Aberdeen (UK), January 6 2021. A study and meta-analysis reported on December 31, 2020 in the European Journal of Epidemiology found a lower risk of premature mortality from any cause among men and women who consumed moderate amounts of calcium. Supplementing with calcium was associated with a lower risk of mortality from all causes among women. Tiberiu A. Pana and colleagues conducted a study that examined the effects of calcium among 17,968 participants in the European Prospective Investigation of Cancer, Norfolk (EPIC-Norfolk). The results were then included in a meta-analysis of 26 studies with a total of 1,828,149 subjects that evaluated the association between calcium intake and all-cause mortality, cardiovascular mortality, and incident cardiovascular disease, aortic stenosis, heart failure, myocardial infarction, peripheral vascular disease and stroke. When divided into fifths according to amount of their calcium intake, EPIC-Norfolk participants whose intake of calcium was between 771 mg and 926 mg per day had a 9% lower risk of dying from any cause and participants whose intake was 1074 mg to 1254 mg had a 15% lower risk in comparison with subjects whose intake was among the lowest fifth at less than 770 mg. Cardiovascular disease mortality was also reduced in these groups. A moderate intake of calcium was associated with a significantly lower risk of stroke, while the reduction in risk associated with an intake of more than 1255 mg per day failed to reach significance. The meta-analysis found a lower risk of all-cause mortality in association with higher calcium intake compared to lower intake. Calcium supplementation was associated with lower all-cause mortality among women, while no significant association was observed among men. “Moderate dietary calcium intake may protect against cardiovascular and all-cause mortality and incident stroke,” the authors concluded. Health benefits of replacing wheat flour with chickpea flour Kings College London and Quadram Institute, January 11, 2021 Researchers from the Quadram Institute and King's College London have shown that replacing wheat flour with a new ingredient derived from chickpeas improved the glycaemic response of people eating white bread. The ingredient uses specially developed milling and drying processes that preserves cellular structure, making its starch more resistant to digestion. Developing food products that contain more of this resistant starch would help to control blood glucose levels and reduce risk of type 2 diabetes. Starch from wheat is a major source of dietary carbohydrate, but in bread and many other processed foods it is quickly digested to glucose in the body, causing a large spike in blood glucose levels. There is a large body of evidence that links long-term consumption of foods that provoke high glycaemic responses to the development of Type II diabetes. With this condition on the rise, along with obesity and other metabolic disorders, providing foods and ingredients that help consumers better manage blood glucose could help combat these challenges to health. Many pulses, such as chickpeas, peas, beans and lentils naturally contain high amounts of resistant starch, which is digested slowly and avoids potentially damaging blood glucose spikes. But most of this beneficial resistance is lost, rendering the starch highly digestible, when these crops are milled to flour and processed into a food product. For this reason, the scientists invented an alternative milling process, which preserves the plant cell wall structures (dietary fiber) that surround the starch. This 'Type 1' resistant starch is the same as that found in wholefoods, but this new ingredient can be used in a form that potentially allows it to be incorporated into a wider range of foods. Funding from the Biotechnology and Biological Sciences Research Council (BBSRC), part of UKRI, was used to develop the commercial potential of this novel ingredient, referred to as PulseON, and expands the possibilities for including large amounts of resistant starch in processed foods to improve nutritional quality. And now, in a new study published in the journal Food Hydrocolloids, the research team shows for the first time that the resistant property of the starch is retained during bread making, and that people who ate bread rolls where some wheat flourwas replaced by PulseON had lower blood glucose responses. In a double blind randomized cross over study, the scientists replaced 0%, 30% or 60% of the wheat flour in a standard white wheat bread recipe with PulseON. Healthy human participants consumed each type of bread roll type for breakfast in random order on separate days, with no knowledge of which type of roll they were eating. Their glucose levels were recorded using continuous glucose monitors. Blood glucose responses to the PulseON enriched breads were on average 40% lower than after eating the control breads. All bread rolls contained similar amounts of starch and wheat protein (gluten) per serving, so the different blood glucose responses reflect the carbohydrate quality. These results raise the possibility of using such foods for improving the dietary management of diabetes, which needs to be evaluated in future studies. The digestion of starch in each bread type was also studied in a laboratory using biochemical and microscopy techniques. These experiments showed that after two hours of digestion, the wheat starch had been digested, but the type-1-resistant starch remained. This confirms that the lower glucose response to PulseON enriched breads was due to the resistant starch enclosed in the chickpea ingredient not being digested. "Incorporating our new type of flour into bread and other staple foods provides an opportunity to develop the next generation of low glycaemic food products to support public health measures to improve health through better diets" said Dr. Cathrina Edwards from the Quadram Institute. "Consumers replacing wheat bread with PulseON enriched bread would benefit not only from the type 1 resistant starch, but also from the higher fiber and protein content." For widespread acceptance, the qualities of the products such as their taste, texture and appearance need to match those that are so popular with consumers. Participants gave the PulseON enriched breads similar scores for texture and taste as the white bread. Quality tests indicated that any effects on bread quality (texture, appearance) were subtle and most noticeable when large amounts of PulseON were used. The sensory properties need to be confirmed with a broader consumer group in a non-clinical setting, but are very encouraging for efforts to produce healthier white bread without adverse effect on product quality. The technology is patent-protected and the group are looking at commercial exploitation. Previous research from the same group has shown that the same milling process may be applied to other beans, lentils and pulses, resulting in cellular powders high in resistant starch, but with different colors and flavors. The researchers are now exploring ingredient applications in a broader range of foodproducts, and planning further trials involving those with prediabetes and type 2 diabetes. Traditional Chinese water-only fasting associated with reduced thrombosis risk Soochow University School of Medicine (China), January 4, 2021 According to news reporting based on a preprint abstract, our journalists obtained the following quote sourced from medrxiv.org: “Beego is a traditional Chinese complete water-only fasting practice initially developed for spiritual purposes, later extending to physical fitness purposes. Beego notably includes a psychological induction component that includes meditation and abdominal breathing, light body exercise, and ends with a specific gradual refeeding program before returning to a normal diet. Beego has regained its popularity in recent decades in China as a strategy for helping people in subhealthy conditions or with metabolic syndrome, but we are unaware of any studies examining the biological effects of this practice. “To address this, we here performed a longitudinal study of beego comprising fasting (7 and 14 day cohorts) and a 7-day programmed refeeding phase. “In addition to detecting improvements in cardiovascular physiology and selective reduction of blood pressure in hypertensive subjects, we observed that beego decreased blood triacylglycerol (TG) selectively in TG-high subjects and increased cholesterol in all subjects during fasting; however, the cholesterol levels were normalized after completion of the refeeding program. Strikingly, beego reduced platelet formation, activation, aggregation, and degranulation, resulting in an alleviated thrombosis risk, yet maintained hemostasis by sustaining levels of coagulation factors and other hemostatic proteins. Mechanistically, we speculate that downregulation of G6B and MYL9 may influence the observed beego-mediated reduction in platelets. Fundamentally, our study supports that supervised beego reduces thrombosis risk without compromising hemostasis capacity. Moreover, our results support that beego under medical supervision can be implemented as noninvasive intervention for reducing thrombosis risk, and suggest several lines of intriguing inquiry for future studies about this fasting practice Assessing the antimicrobial activity of flaxseed NGH Institute of Dental Sciences & Research Centre (India), January 5, 2021 Researchers in India evaluated the antimicrobial activity of flaxseed against known periodontal pathogens. They reported their findings in an article published in the International Journal of Herbal Medicine. Research suggests that the use of antibiotics is beneficial in the management of periodontitis. However, antibiotic resistance has now become a major global issue, and it is believed to have stemmed from the misuse of antibiotics. Many researchers now see herbal interventions as therapeutic strategies that deserve more research and attention. Flaxseed, a popular superfood rich in omega-3 fatty acids, has demonstrated potent antimicrobial and anti-biofilm activities in several studies. To further explore its potential, the researchers conducted an in vitro study that aims to assess the antimicrobial activity of flaxseed against periodontal pathogens. They prepared an ethanolic extract from flaxseed powder and determined its minimum inhibitory concentration (MIC) and minimum bactericidal concentration (MBC) against Porphyromonas gingivalis, Aggregatibacter actinomycetemcomitansand Tannerella forsythia. The researchers reported that the flaxseed extract exhibited bacteriostatic activities against all three pathogens. At 100 microliters (uL)/milliliter (mL), the extract exerted bactericidal effects against P. gingivalis. Based on these findings, the researchers concluded that flaxseed can be used as a natural adjunct to periodontal therapy because of its bactericidal effects against P. gingivalis. Vitamin B3 may benefit those with Parkinson's disease University of Leicester, January 11, 2021 Individuals with a specific type of Parkinson's disease (PD) could gain from increasing vitamin B3 (niacin) content in their diet, say British investigators. The findings point to niacin’s ability to increase levels of a compound responsible for energy generation and DNA repair. These factors — if left unattended — result in faulty mitochondria function that contributes to the progression of the neuro-degenerative disorder. "This study strengthens the therapeutic potential for Vitamin B3/niacin-based dietary interventions in the treatment of Parkinson's disease," said Dr Miguel Martins, lead study author and programme leader of the MRC Toxicology Unit at the University of Leicester. Niacin or Vitamin B3 is found in a number of foods, including liver, chicken, beef, fish, cereal, peanuts, and legumes. It can also be made from tryptophan, an essential amino acid found in most forms of protein. The team began by looking at studying fruit flies, specifically bred with a mutation that mimics PD. These flies specifically had a mutated form of the PINK1 gene that normally protects cells from stress-induced mitochondrial malfunction.   Flies were then fed food supplemented with niacin, which is made into the compound NAD inside the body. With this additional source of NAD, the researchers found flies had a lower number of faulty mitochondria than their mutant cohorts fed a regular diet. In addition, niacin also prevented the flies from losing existing neurons. “Mutations in PINK1 prevent cells from clearing out the defective powerhouses. When they accumulate, neurons can't get enough energy and die. The faulty mitochondria also release toxic molecules that damage their genes encoded by DNA,” said Dr Martins. “With all the mitochondrial damage going on, we wondered if in cases of Parkinson's the NAD compound ends up in short supply." The team also found that stopping DNA repair from depleting NAD kept mitochondria healthy and neurons alive, as well as enhance the flies' strength, mobility and lifespan. "The results suggest that in familial Parkinson's, available NAD is critical for keeping mitochondria in shape and the disease at bay,” said Dr Martins. While drug treatments exist that block NAD-consumption during the DNA repair process, Dr Martins thought increasing dietary niacin could provide certain benefits. "While neither of these would be cures, they would expand treatment options for Parkinson's patients with faulty mitochondria,” he added. excluded Study finds unfavorable intestinal microflora levels associated with the development of postmenopausal osteoporosis Fujin University (China), December 27, 2020 According to news reporting originating from Fujian, People’s Republic of China, research stated, “We aimed to investigate the intestinal microecology and fibroblast growth factor (FGF) expression in women with postmenopausal osteoporosis (PMO) and their clinical value in the diagnosis of PMO. A total of 214 postmenopausal women were analyzed retrospectively.” Our news editors obtained a quote from the research from the Department of Orthopedics, “The women were divided into the abnormal group (103 cases) and the normal group (111 cases) according to their bone mineral density (BMD). The levels of intestinal microflora and serum FGF-21, FGF-23, alpha-klotho, and beta-klotho were compared between the two groups, and the correlations of intestinal microflora, FGF-23, alpha-klotho, and beta-klotho with BMD were analyzed. The women in the abnormal group were further divided into the osteoporosis subgroup (59 cases) and the osteopenia subgroup (44 cases) for comparison. Receiver operating characteristic (ROC) curve was plotted to analyze the diagnostic value of intestinal microflora, FGF-23, alpha-klotho and beta-klotho for PMO. Compared with the normal group, the abnormal group had lower levels of bifidobacterium, lactobacillus, alpha-klotho, and beta-klotho and higher levels of enterococcus and FGF-23 (all P

On this week's episode of Fast Facts - Perio Edition your host, Katrina Sanders, RDH takes us through red complex bacteria!   Quotes:    “These red complex bacteria are Tannerella forsythia, Treponema denticola, and the Regina George of red complex bacteria Porphyromonas gingivalis.”   “It is believed that once these bacteria are present, that the body is in a complete state of oral inflammatory conditions and this is where we begin to see periodontal disease truly manifest.”   Resources:   DentistRX: https://www.dentistrx.com  More Fast Facts: https://www.ataleoftwohygienists.com/fast-facts/    Katrina Sanders Website: https://www.katrinasanders.com  Katrina Sanders Instagram: https://www.instagram.com/thedentalwinegenist/

On this week’s episode of Fast Facts - Perio Edition your host, Katrina Sanders, RDH takes us through red complex bacteria!   Quotes:    “These red complex bacteria are Tannerella forsythia, Treponema denticola, and the Regina George of red complex bacteria Porphyromonas gingivalis.”   “It is believed that once these bacteria are present, that the body is in a complete state of oral inflammatory conditions and this is where we begin to see periodontal disease truly manifest.”   Resources:   DentistRX: https://www.dentistrx.com  More Fast Facts: https://www.ataleoftwohygienists.com/fast-facts/    Katrina Sanders Website: https://www.katrinasanders.com  Katrina Sanders Instagram: https://www.instagram.com/thedentalwinegenist/

Fungos, bactérias e vírus são parte da microbiota das mãos e da boca. Quando em desequilíbrio, esses microorganismos podem trazer riscos à saúde de adultos e crianças. Para evitar essas situações, a saída é higienizar corretamente as mãos e a boca. Este episódio do Momento Odontologia explica qual a melhor maneira de realizar isso, com a participação de Carina Domaneschi, do Departamento de Estomatologia da Faculdade de Odontologia (FO) da USP. Entre os fungos, os gêneros Trichophyton, Microsporum e Aspergillus apresentam algumas espécies patogênicas ao homem, enquanto que o Candida, que faz parte da flora normal da cavidade bucal, pode  causar candidíase oral entre 20 a 72% das pessoas. Agentes bacterianos como o Streptococcus mutans e Porphyromonas gingivalis podem causar a cárie e gengivite, respectivamente. No ser humano, os vírus são responsáveis por causar gripe, rubéola, catapora, entre outras doenças. Por isso a higiene adequada é imprescindível para evitar contaminações. Além de água e sabão – essencial para conter a via de transmissão fecal-oral – é necessário, após umedecer as mãos, passar sabonetes ou álcool gel na planta e no dorso das mãos, entre os dedos, pulsos e unhas. Na hora de secar, o mais higiênico é usar o papel toalha. Já em relação à correta higienização da boca, para prevenir cáries e doenças gengivais, a escovação aliada ao fio dental diminuem a incidência de cáries e de mau hálito. Ficha Técnica Edição sonora: Gabriel Soares Produção: Rosemeire Talamone e Leticia Acquaviva Para receber atualizações com novos episódios, assine o feed do podcast Momento Odontologia. Estamos também no Spotify, no iTunes, Google Podcasts, entre outros apps. E toda segunda-feira, às 8h05, na Rádio USP (93,7 FM em São Paulo, 107,9 em Ribeirão Preto e streaming).

Have you lost a loved one physically or mentally from dementia or Alzheimers? It is a devastating disease to watch. As our population lives longer, I think their are many of us more worried about losing our minds while living than actually facing death. Dr. Jill Wade and Aurelia Bryne RDH discuss the latest news in scientific research that links the cause of Alzheimers directly to dentistry. A bacteria called Porphyromonas gingivalis is a common bacteria in the cause of gum disease. This same bacteria was announced to be a potential causative player in the onset and progression of the destructive process of Alzheimers. The good news is that we were already watching this aggressive pathogen as a high risk factor for cardiovascular disease and can diagnose it easily with OralDNA testing. Periodontal therapy, scaling and root planning, deeper cleanings all describe techniques we use to address optimizing the gum around teeth and reducing the infection of p. gingivalis and many other harmful bacterias. This episode of the SymplifiHealth podcast provides more science supporting another important reason to get to your dentist on a regular basis and keep your gums healthy. And we as dental professionals need stop apologizing for telling our patients that they have periodontal disease. We are trying to save their lives and save their minds!

  Show Notes By Jacqueline Posada, MD, 4th-year resident in the department of psychiatry & behavioral sciences at George Washington University, Washington. Guest George T. Grossberg, MD: Samuel W. Fordyce Professor; director, geriatric psychiatry at Saint Louis University. Dr. Grossberg spoke at the American Academy of Clinical Psychiatrists 2019 annual meeting in Chicago, sponsored by Global Academy for Medical Education (GAME). GAME and the MDedge Psychcast are owned by the same company.   New developments in Alzheimer’s research The Systolic Blood Pressure Intervention Trial, also known as the SPRINT MIND Study, showed that tightly controlled systolic blood pressure (SBP) of 120 mm Hg, compared with an SBP of 140 mm Hg, resulted in a 20% reduced risk of developing mild cognitive impairment. The SPRINT study was terminated early at the median follow-up of 3.26 years as its results showed that tightly controlled SBP significantly reduces the risk of stroke and heart disease. The Alzheimer’s Association has agreed to fund an additional 2 years of the SPRINT MIND Study to evaluate whether tightly controlled BP is effective in reducing the risk of Alzheimer’s disease. In the brain, the glymphatic system was discovered in 2012 and is similar to the lymphatic system in its role as a drainage system for removing toxins. Glial cells mediate toxin removal, and the glymphatic system removes toxins that eventually can cause cell death in the brain. Because the glymphatic system is involved in removing the beta-amyloid plaques that contribute to cell death in AD, the glymphatic system is another area of investigation in the pathogenesis of AD. Novel treatment of moderate to advanced AD involves using plasma infusion. Infusion of plasma products from healthy, nonimmunocompromised 18-year-old individuals into older patients with AD is a potential treatment for AD. Precedent for this intervention comes from animal studies investigating parabiosis, a procedure in which two animals are connected so that they share each other’s blood stream. When such a circulatory exchange occurs between a younger mouse and an older mouse with AD, the older AD model mouse regains cognitive abilities and is able to complete mazes that it was unable to complete before. How can this model be adapted to humans? One possibility might involve infusing plasma from young healthy individuals into older adults with advanced AD. A safety proof-of-concept study, published recently, found that plasma products can be safely infused. The next step is an efficacy study. A relationship has been found between AD and periodontal disease. The primary bacteria related to periodontal disease, Porphyromonas gingivalis, is found in close proximity in the brain to the plaques and tangles of AD. One theory posits that the presence of this bacteria is related to inflammation that may contribute to the causality of AD. Could AD be treated with the antibiotics used to treat periodontal disease? The answers remain unclear. Aducanumab, a monoclonal antibody targeting the beta-amyloid plaques of AD, initially showed favorable changes in imaging studies of the brains of people with AD. In March 2019, the study was halted because of futility. An independent data-monitoring committee determined that the early results seen on imaging did not result in clinically meaningful changes, compared with placebo. Some AD researchers consider this drug failure the “final nail in the coffin” of the amyloid hypothesis, and the pathogenesis of AD is most likely related to tau neurofibrillary tangles and other mediators, such as the immune system and inflammation.   References SPRINT Research Group. A randomized trial of intensive versus standard blood-pressure control. N Engl J Med. 26 Nov 2015;373:2103-16. Jessen NA et al. The glymphatic system: A beginner’s guide. Neurochem Res. 2015 Dec;40(12):2583-99. Dominy SS et al. Porphyromonas gingivalis in Alzheimer’s disease brains: Evidence for disease causation and treatment with small-molecule inhibitors. Science Advances. 23 Jan 2019;5(1): doi: 10.1126//sciadv.aau3333. Conese M et al. The fountain of youth: A tale of parabiosis, stem cells, and rejuvenation. Open Med (Wars). 2017;12:376-83. Phase 3 study of aducanumab in early Alzheimer’s disease. ClinicalTrials.gov Identifier: NCT02477800.   For more MDedge Podcasts, go to mdedge.com/podcasts Email the show: podcasts@mdedge.com Interact with us on Twitter: @MDedgePsych  

Links Ep. 5 – How do we know what works?, in which we discussed Jennifer Doleac’s work previously. Jennifer Doleac’s thread on Twitter Working on criminal justice topics gives me a very different perspective on the Kochs than my equally-liberal friends & family have. Charles Koch Foundation & Charles Kock Institute are perhaps the most important funders of research related to criminal justice policy & reform. They also frequently host conferences that bring top-notch researchers and practitioners together in one room — a chance to meet everyone else who’s working in this space. In other words, they throw great parties — sounds trivial but this is super important & helpful! Charles Koch Foundation has funded my own work related to prisoner reentry and I am deeply grateful for that as well as their broader support of my research. My contacts there & Charles Kock Institute are the first I call if I’m looking for practioner contacts. They know everyone! As funders they are extremely hands-off — to a degree that is almost funny. I think they know people are watching them closely for missteps so are super careful. But most funders in this space have strong opinions abt what you should study & what you should find. They don’t. Koch Industries for a long time was a major proponent of Ban the Box policies. When my research on BTB (which they did not fund) came out, showing detrimental effects, they were eager to hear about it & engage w the results. I really appreciated that. To my fellow liberals that love to hate the Koch brothers, I simply say: the story is more complicated (as always, right?). Charles Koch in particular is enabling & supporting evidence-based CJ reform in red & blue states alike, and that is something we should all appreciate. “Ban the Box” does more harm than good, by Jennifer Doleac, May 31, 2016 (Brookings) Arnold Foundation Laura Arnold’s Podcast (Apple Podcasts) The Replication Crisis (Wikipedia) The File Drawer Problem (Wikipedia) Academic Tenure (Wikipedia) Example of Correlation-Causation Escalation Periodontal Disease Bacteria Linked To Alzheimer’s Disease (American Academy of Periodontology) The study, published in the journal Science Advances, uncovered a potential link between P. gingivalis, the bacteria associated with periodontal disease (commonly known as gum disease) and Alzheimer’s. Porphyromonas gingivalis in Alzheimer’s disease brains: Evidence for disease causation and treatment with small-molecule inhibitors (Science Advances) Infectious agents have been found in the brain and postulated to be involved with AD, but robust evidence of causation has not been established.

Michael and Vincent discuss the finding of immunity to Cas9 protein in humans, and a potential role for an oral bacterium in Alzheimer’s disease. Subscribe to TWiM (free) on Apple Podcasts, Google Podcasts, Android, RSS, or by email.Get the entire ASM Podcast Network via our Microbeworld app. Become a patron of TWiM. Links for this episode Immunity to Cas9 protein in humans (Nat Med) P. gingivalis and Alzheimer’s disease (Science) Clinical trial of COR388 in AD patients (clinicaltrials.gov) TWiM Listener survey Send your microbiology questions and comments (email or recorded audio) to twim@microbe.tv  

Add Alzheimer's disease to the growing list of medical conditions that are looking to dentistry for a solution. Could we cure Alzheimer's by controlling the periodontal pathogen Porphyromonas gingivalis?

Epidemiological studies have indicated a relationship between coronary heart disease (CHD) and periodontitis. Recently, CDKN2BAS was reported as a shared genetic risk factor of CHD and aggressive periodontitis (AgP), but the causative variant has remained unknown. To identify and validate risk variants in different European populations, we first explored 150 kb of the genetic region of CDKN2BAS including the adjacent genes CDKN2A and CDKN2B, covering 51 tagging single nucleotide polymorphisms (tagSNPs) in AgP and chronic periodontitis (CP) in individuals of Dutch origin (n=313). In a second step, we tested the significant SNP associations in an independent AgP and CP population of German origin (n=1264). For the tagSNPs rs1360590, rs3217992, and rs518394, we could validate the associations with AgP before and after adjustment for the covariates smoking, gender and diabetes, with SNP rs3217992 being the most significant (OR 1.48, 95% CI 1.19 to 1.85; p=0.0004). We further showed in vivo gene expression of CDKN2BAS, CDKN2A, CDKN2B, and CDK4 in healthy and inflamed gingival epithelium (GE) and connective tissue (CT), and detected a significantly higher expression of CDKN2BAS in healthy CT compared to GE (p=0.004). After 24 h of stimulation with Porphyromonas gingivalis in Streptococcus gordonii pre-treated gingival fibroblast (HGF) and cultured gingival epithelial cells (GECs), we observed a 25-fold and fourfold increase of CDKN2BAS gene expression in HGFs (p=0.003) and GECs (p=0.004), respectively. Considering the global importance of CDKN2BAS in the disease risk of CHD, this observation supports the theory of inflammatory components in the disease physiology of CHD.

The pathogen Porphyromonas gingivalis evades the innate immune system by initiating signaling crosstalk.

Überprüfung der Wirksamkeit stallspezifischer Vakzinen zur Bekämpfung der Dermatitis digitalis bei Milchkühen Die Studie wurde als kontrollierter Doppelblindversuch durchgeführt. Die Untersuchungen fanden in einem Milchviehbetrieb in Norddeutschland statt (429 Tiere bei der ersten Untersuchung). Aus den Hautbioptaten typischer DD-Läsionen wurden folgende Erreger im anaeroben Bereich isoliert: Porphyromonas ssp., Porphyromonas levii, Porphyromonas endodonatales, Fusobacterium necrophorum, Bac. stercoris, Prevotella bivis, Peptostreptococcus indolicus, Treponema sp.. Daraus wurden zwei formalininaktivierte Adsorbatvakzinen hergestellt. Die eine enthielt alle Keimarten außer Treponema sp. (Impfgruppe A), die andere alle Keimarten und Treponema sp. (Keimanteil 20 %) aus einer Schüttelkulturvermehrung (Impfgruppe B). Als Placebo wurde die Impflösung ohne Antigen verwendet (Kontrollgruppe). Verabreicht wurden je 5 ml Impfstoff oder Placebo subkutan. Der Klauengesundheitsstatus wurde im Oktober 1998, März 1999, Oktober 1999 und im Januar 2000 im Rahmen der halbjährlich durchgeführten funktionellen Klauenpflege erfasst und die Befunde der Hintergliedmaßen dokumentiert. Die erste Impfung erfolgte im Dezember 1998, die zweite drei Wochen später, die weiteren Impfungen fanden im März 1999 und im November 1999 statt. Zwischen der ersten und vierten Untersuchung durchgeführte Klauen- und Antibiotikabehandlungen wurden vom Betriebsleiter protokolliert. Die Auswertung erbrachte folgende Ergebnisse: 1. Zu keinem der vier Untersuchungszeitpunkte bestanden signifikante Unterschiede bezüglich der Prävalenzen der DD in den zwei Impfgruppen und der Kontrollgruppe. Die Prävalenzen der DD bewegten sich zum Zeitpunkt der vier Untersuchungen um 36 %, 42 %, 51 % und 38 %. 2. An Hintergliedmaßen, die bei der Erstuntersuchung DD-Läsionen aufwiesen, konnten auch bei den Folgeuntersuchungen in den zwei Impfgruppen und der Kontrollgruppe jeweils etwa gleichhäufig derartige Veränderungen diagnostiziert werden. 3. An Hintergliedmaßen, die bei der Erstuntersuchung frei von DD waren, konnten bei den Folgeuntersuchungen in den zwei Impfgruppen und der Kontrollgruppe jeweils etwa gleichhäufig DD-Läsionen diagnostiziert werden. 4. Die Scorewerte (nach DÖPFER, 1994) DD positiver Tiere - als Maßzahl für den Schweregrad der DD-Veränderung - waren zu den vier Untersuchungszeitpunkten in den zwei Impfgruppen und der Kontrollgruppe statistisch nicht signifikant verschieden. 5. Der „maximale gewichtete Flächenindex (max. GFI)“ - als weitere Bewertungsgrundlage für den Schweregrad der DD - war bei den Untersuchungen U2 und U3 in den Impfgruppen und der Kontrollgruppe nicht statistisch signifikant verschieden. Bei U1 war in der Impfgruppe B ein statistisch signifikant höherer Mittelwert (x) festzustellen als in der Kontrollgruppe (x = 82; p = 0,006). Bei U4 war in der Kontrollgruppe ein statistisch signifikant niedrigerer Mittelwert (x) festzustellen als in den Impfgruppen (x = 22,5; p = 0,033). 6. Die Häufigkeit von Klauen- und Antibiotikabehandlungen sowie der Einfluss von DD-Läsionen auf die Abgangsursache waren in den zwei Impfgruppen und der Kontrollgruppe statistisch nicht signifikant verschieden. In der vorliegenden Impfstudie konnte weder eine prophylaktische noch eine therapeutische Wirkung durch die verwendeten stallspezifischen Vakzinen bei der Bekämpfung der Dermatitis digitalis festgestellt werden. Auch das Hinzufügen von Treponema sp. erbrachte keinen Effekt auf die Wirksamkeit des Impfstoffs.