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“The signaling and that binding of the MET and the HGF help, in a downstream way, lead to cell proliferation, cell motility, survival, angiogenesis, and also invasion—so all of those key cancer hallmarks. And because of it being on an epithelial cell, it's a really good marker because it's found in many, many different types of cancers, so it makes it what we call kind of a nice actionable mutation,” ONS member Marianne Davies, DNP, ACNP, AOCNP®, FAAN, senior oncology nurse practitioner at Yale Comprehensive Cancer Center in New Haven, CT, told Jaime Weimer, MSN, RN, AGCNS-BS, AOCNS®, manager of oncology nursing practice at ONS, during a conversation about the MET inhibitor drug class. Music Credit: “Fireflies and Stardust” by Kevin MacLeod Licensed under Creative Commons by Attribution 3.0 Earn 0.5 contact hours of nursing continuing professional development (NCPD) by listening to the full recording and completing an evaluation at courses.ons.org by May 9, 2026. The planners and faculty for this episode have no relevant financial relationships with ineligible companies to disclose. ONS is accredited as a provider of nursing continuing professional development by the American Nurses Credentialing Center's Commission on Accreditation. Learning outcome: Learners will report an increase in knowledge related to MET inhibitors. Episode Notes Complete this evaluation for free NCPD. ONS Podcast™ episodes: Pharmacology 101 series Episode 330: Stay Up to Date on Safe Handling of Hazardous Drugs ONS Voice articles: Oncology Drug Reference Sheet: Amivantamab-Vmjw Oncology Drug Reference Sheet: Cabozantinib Oncology Drug Reference Sheet: Capmatinib Oncology Drug Reference Sheet: Tepotinib Predictive and Diagnostic Biomarkers: Identifying Variants Helps Providers Tailor Cancer Surveillance Plans and Treatment Selection ONS books: Chemotherapy and Immunotherapy Guidelines and Recommendations for Practice (second edition) Clinical Guide to Antineoplastic Therapy: A Chemotherapy Handbook (fourth edition) Safe Handling of Hazardous Drugs (fourth edition) Telephone Triage for Oncology Nurses (third edition) ONS courses: Safe Handling Basics ONS Biomarker Database ONS Huddle Cards: Monoclonal Antibodies Targeted Therapy ONS Oral Anticancer Medication Learning Library ONS Oral Anticancer Medication Toolkit ONS and NCODA Oral Anticancer Medication Compass Oral Chemotherapy Education Sheets IV Chemotherapy Education Sheets Drugs@FDA To discuss the information in this episode with other oncology nurses, visit the ONS Communities. To find resources for creating an ONS Podcast Club in your chapter or nursing community, visit the ONS Podcast Library. To provide feedback or otherwise reach ONS about the podcast, email pubONSVoice@ons.org. Highlights From This Episode “The MET receptor was actually identified back in 1984. And it was actually identified as an oncogene in osteosarcoma. And so basically what that MET receptor does—it's a tyrosine kinase pathway, and the ligand that it attaches to is something called HGF/SF. That's hepatocyte growth factor/scatter factor. And so this MET pathway tyrosine kinase pathway is really important in tumor cell growth and migration. And it's expressed specifically on epithelial cells, so that's going to really help us in identifying how it can be a pathway for cancer treatments.” TS 1:35 “But in the particular classes, there kind of are some unique things that are with these MET inhibitors. For example, crizotinib, we found early on, causes some vision changes. Patients would report things like floaters or a little bit of blurry vision. For the capmatinib, things like elevation of amylase and lipase, fluid retention and bloating, and hypersensitivity reactions and photosensitivity.” TS 7:36 “Other things to teach for the TKI is the self-management strategies in terms of nausea management and dietary changes for the risk of peripheral edema. Having them do things like maybe doing daily weights, or at least weights every other day, and sometimes doing limb measurements so it can help us really quantify the amount of fluid retention they have. And then from a nursing perspective, meeting with these patients, is to do really good skin inspection. When people have peripheral edema, they're at risk for skin breakdown, and that can lead obviously to infection.” TS 16:06 “The biggest [misconception] is that people assume that all MET mutations are going to be equally responsive to the same targeted therapies, that all of the abnormalities are the same and react the same, and they really don't. We're really diving down and carving that pie thinner and thinner in terms of each individual MET abnormality, in terms of what drugs responds it to and what that means for patient outcomes and prognosis.” TS 25:21
In today's episode, host Chris Duffin dives deep into the fascinating world of cognitive enhancement with special guest Anthony Castor. We'll explore a range of nootropic peptides and supplements designed to boost brain function, resilience, and overall well-being. Chris and Anthony discuss such potent peptides as C Max and Celnac, revealing their roles in cognitive enhancement, neuroprotection, and stress resistance. We'll learn about Synapsin's ginsenoside RG3, and its anti-aging properties, and the intriguing nootropic properties of NewPEPT. Listen as Anthony shares personal anecdotes about using compounds like Dihexa for synapse formation and modafinil for enhancing wakefulness and cognitive performance. Throughout the conversation, we'll also delve into the science behind these compounds, examining their neurotransmitter modulation, neuroprotection, and practical applications for high-stress jobs, shift work, and productivity boosts. Additionally, we'll cover lifestyle practices that complement these cognitive enhancers, emphasizing the importance of sleep, hydration, and a balanced diet. This episode of the ARCHITECT of RESILIENCE podcast is available on Apple, Spotify & YouTube, and is sponsored by @marekhealth : Performance. Longevity. Optimization.
In this comprehensive video, we delve into various advanced therapies and supplements that can significantly enhance brain health and support recovery from brain injuries. Join us as we explore the science behind exogenous ketones, Dihexa, Cerebrolysin, Selank, Semax, plasmalogens, hyperbaric oxygen therapy (HBOT), and photobiomodulation. Learn how these innovative treatments work and their potential benefits for cognitive function and brain health. Topics Covered: Exogenous Ketones: Alternative energy source for the brain, anti-inflammatory effects, neuroprotection, and promotion of brain plasticity. Dihexa: Neurogenic and neurotrophic properties, enhancement of cognitive function, and promotion of synaptogenesis and neurogenesis. Cerebrolysin: Neurotrophic factors, neuroprotection, neuroplasticity, and cognitive function improvement. Selank and Semax: Anxiolytic and cognitive-enhancing effects, neuroprotection, and influence on neurotransmitter systems. Plasmalogens: Phospholipids, membrane integrity, oxidative stress reduction, and support for neurogenesis. Hyperbaric Oxygen Therapy (HBOT): Enhanced oxygen delivery, reduced inflammation, neuroprotection, and promotion of neurogenesis and angiogenesis. Photobiomodulation: Red and near-infrared light therapy, mitochondrial function enhancement, and neuroprotection. Research References: Cerebrolysin: - Study on Cerebrolysin and Neuroprotection in Stroke Journal of Neurology - Research on Cerebrolysin's impact on cognitive function and neuroplasticity. Dihexa: - Dihexa's Effects on Cognitive Enhancement and Neurogenesis Neuroscience Letters - Study on Dihexa and its binding to HGF receptors, promoting synaptogenesis. Selank and Semax: - Selank: Anxiolytic and Cognitive-Enhancing Properties - Semax: Neuroprotective and Cognitive-Enhancing Effects Journal of Molecular Neuroscience - Research on Selank and Semax's mechanisms and benefits. Hyperbaric Oxygen Therapy (HBOT): - HBOT for Stroke Recovery Journal of Neurotrauma - Studies on the effectiveness of HBOT in brain injury recovery and neuroprotection. Key Points: Exogenous ketones provide an alternative energy source and possess anti-inflammatory and neuroprotective properties. Dihexa enhances cognitive function by promoting neurogenesis and synaptogenesis. Cerebrolysin supports neuronal survival, neuroplasticity, and cognitive function. Selank and Semax offer anxiolytic and cognitive-enhancing benefits, influencing neurotransmitter systems and providing neuroprotection. Plasmalogens support membrane integrity, reduce oxidative stress, and promote neurogenesis. HBOT enhances oxygen delivery, reduces inflammation, promotes neuroprotection, and supports neurogenesis and angiogenesis. Photobiomodulation uses red and near-infrared light to enhance mitochondrial function and provide neuroprotection. Personalised Health Optimisation Consulting with Lisa Tamati Lisa offers solution focused coaching sessions to help you find the right answers to your challenges. Topics Lisa can help with: Lisa is a Genetics Practitioner, Health Optimisation Coach, High Performance and Mindset Coach. She is a qualified Ph360 Epigenetics coach and a clinician with The DNA Company and has done years of research into brain rehabilitation, neurodegenerative diseases and biohacking. She has extensive knowledge on such therapies as hyperbaric oxygen, intravenous vitamin C, sports performance, functional genomics, Thyroid, Hormones, Cancer and much more. She can assist with all functional medicine testing. Testing Options Comprehensive Thyroid testing DUTCH Hormone testing Adrenal Testing Organic Acid Testing Microbiome Testing Cell Blueprint Testing Epigenetics Testing DNA testing Basic Blood Test analysis Heavy Metals Nutristat Omega 3 to 6 status and more Lisa and her functional medicine colleagues in the practice can help you navigate the confusing world of health and medicine . She can also advise on the latest research and where to get help if mainstream medicine hasn't got the answers you are searching for whatever the challenge you are facing from cancer to gut issues, from depression and anxiety, weight loss issues, from head injuries to burn out to hormone optimisation to the latest in longevity science. Book your consultation with Lisa Join our Patron program and support the show Pushing the Limits' has been free to air for over 8 years. Providing leading edge information to anyone who needs it. But we need help on our mission. Please join our patron community and get exclusive member benefits (more to roll out later this year) and support this educational platform for the price of a coffee or two You can join by going to Lisa's Patron Community Or if you just want to support Lisa with a "coffee" go to https://www.buymeacoffee.com/LisaT to donate $3 Lisa's Anti-Aging and Longevity Supplements Lisa has spent years curating a very specialized range of exclusive longevity, health optimizing supplements from leading scientists, researchers and companies all around the world. This is an unprecedented collection. The stuff Lisa wanted for her family but couldn't get in NZ that's what it's in her range. Lisa is constantly researching and interviewing the top scientists and researchers in the world to get you the best cutting edge supplements to optimize your life. Subscribe to our popular Youtube channel with over 600 videos, millions of views, a number of full length documentaries, and much more. You don't want to miss out on all the great content on our Lisa's youtube channel. Youtube Order Lisa's Books Lisa has published 5 books: Running Hot, Running to Extremes, Relentless, What your oncologist isn't telling you and her latest "Thriving on the Edge" Check them all out at https://shop.lisatamati.com/collections/books Perfect Amino Supplement by Dr David Minkoff Introducing PerfectAmino PerfectAmino is an amino acid supplement that is 99% utilized by the body to make protein. PerfectAmino is 3-6x the protein of other sources with almost no calories. 100% vegan and non-GMO. The coated PerfectAmino tablets are a slightly different shape and have a natural, non-GMO, certified organic vegan coating on them so they will glide down your throat easily. Fully absorbed within 20-30 minutes! No other form of protein comes close to PerfectAminos Listen to the episode with Dr Minkoff here: Use code "tamati" at checkout to get a 10% discount on any of their devices. Red Light Therapy: Lisa is a huge fan of Red Light Therapy and runs a Hyperbaric and Red Light Therapy clinic. If you are wanting to get the best products try Flexbeam: A wearable Red Light Device https://recharge.health/product/flexbeam-aff/?ref=A9svb6YLz79r38 Or Try Vielights' advanced Photobiomodulation Devices Vielight brain photobiomodulation devices combine electrical engineering and neuroscience. To find out more about photobiomodulation, current studies underway and already completed and for the devices mentioned in this video go to www.vielight.com and use code “tamati” to get 10% off Enjoyed This Podcast? If you did, subscribe and share it with your friends! If you enjoyed tuning in, then leave us a review and share this with your family and friends. Have any questions? You can contact my team through email (support@lisatamati.com) or find me on Facebook, Twitter, Instagram and YouTube. For more episode updates, visit my website. You may also tune in on Apple Podcasts. To pushing the limits, Lisa and team
We love to hear from our listeners. Send us a message. Built on the back of hepatocyte growth factor discoveries by Harvard Drs. Reza Dana and Sunil Chauhan, ClarisBio is rewriting the ophthalmology rulebook. CEO Clark Atwell acknowledges that it's not the first to bring topically-administered biologic therapies to the front of the eye, but if successful in the clinic, its Neurotrophic Keratitis candidate will vastly improve the patient experience. It will also prove unequivocally that there's biotech business value in front-of-the-eye therapeutics, as opposed to just parenterally-administered back-of-the-eye biologics. On this episode of the Business of Biotech podcast, Atwell shares the stories of his career focus on the cornea, Claris' founding and funding progress, and why there's big, multi-indication opportunity for the company's novel HGF therapeutics in corneal diseases.Register for Bioprocess Online's Bio Expo Live, being held July 30th through August 1st . This inaugural expo is a fantastic opportunity for biopharma companies and contract manufacturers to evaluate the latest and greatest from the comfort of your desktop or mobile device. Conveniently, we've broken down the lineup into Upstream Solutions July 30th, Downstream Solutions July 31st, and Quality, Analytical, and Data Solutions August 1st. It's absolutely free to register for this series of short, digestible, and interactive sessions -- just hit the links above to register for Bio Expo Live today!
Please Subscribe and Review: Apple Podcasts | RSS Submit your questions for the podcast here News Topic: Anthony Fauci failed during the coronavirus response Show Notes: Type 1 Diabetes and CrossFit Is dietary intake associated with salt taste function and perception in adults? A systematic review Precision Health Reports Questions: Low Carb and CrossFit Brandon writes: Hey! I'm a Type 1 diabetic whom used to compete in powerlifting but whom now does mostly Crossfit and Hybrid sports. I've found low carb tends to work best in terms of blood sugar control and when I was powerlifting it didn't seem to hinder performance. However I've noticed I tend to see my performance hindered following a low carb approach while doing CrossFit. Is there a way to have the best of both worlds? I've experimented with glucose tabs and UCAN with some success. Right now I'm debating if getting 150ish carbs from UCAN or sweet potatoes would be a good compromise. Sodium Deficiency Teri writes: Hello Nicki & Robb- I've been a lover and subscriber of LMNT since it was released. I'm a mountain runner and love that I can get my sodium from something that tastes delicious & hydrates me instead of salt pills when I need it. Also the new sparkling LMNT is so good after a long workout. I have something I've wondered though, is it supposed to taste “salty”? To me it tastes more sweet than anything & it's why I usually mix it at about half-power because at full power it's just too sweet for me. I had my son taste it and he said it tasted salty to him. Could that mean I'm deficient if I don't taste it? I do not limit my salt outside of taking LMNT as I am very active and have very low blood pressure (90s/60s) so figure I need all the help I can get. However I do not track it either so I'm not sure how much sodium I get in a day. I eat a very non-strict but healthy, omnivorous diet, the only things I don't consume are gluten and alcohol. Thanks for the insight, and for all your amusing banter! Cardiovascular Risk Brett writes: I'm a 44yo lean male living in Vancouver, Canada - 6'2" 180lbs who is quite active (gardening, Ultimate frisbee, weights, walking, outdoor activities) and after a bout of Lyme disease 10 years ago I have been very careful with my diet and lifestyle. I do the AIP style of eating at least once a year, generally eating Paleo with more carbs over Summer when I am more active. I am a shift worker but try to avoid the midnight shifts where I can as I know the loss of sleep affects me; I have a family history of heart issues which of course raises my risk profile on most tests. About once a year I get bloodwork done to keep on top of my health as I get older. Recently I had a SmartHealth Dx test done with my Naturopath. My IL16, FAS, Eotaxin and HGF scores were elevated giving me a heart age of over 80 years old. General blood test at the same time had Hemoglobin A1C at 5.7%, cholesterol 7.11 mmol/L, LDL cholesterol 4.59 mmol/L, HDL cholesterol 2.38 mmol/L, Apoliprotein A-1 2.22 g/L, triglycerides 0.31 mmol/L. Any thoughts on how these results could be? I am very active, I do work hard but I try to be conscious of when I am overdoing it (as I am a list maker with many things "to do"!!) Thanks so much for reading. Sponsor: The Healthy Rebellion Radio is sponsored by our electrolyte company, LMNT. Proper hydration is more than just drinking water. You need electrolytes too! Check out The Healthy Rebellion Radio sponsor LMNT for grab-and-go electrolyte drink mix packets and the new LMNT Sparkling electrolyte performance beverage! Click here to get your LMNT electrolytes Transcript: Coming soon! .
Nessa live, eu conversei com os Neurologistas Dra. Ivna Lacerda (@IvnaLacerda) sobre Neuroimunologia. Ivna Lacerda é Médica pela Universidade de Fortaleza (UNIFOR). Tem Residência Médica em Neurologista pelo Hospital Geral de Fortaleza (HGF) E fellow em Neuroimunologia tamb ém pelo HGF. Atualmente é mestranda em Ciências Médicas na UNIFOR Acompanhe-nos em nosso Podcast Rebelião Saudável: Spotify: http://bit.ly/rebeliaosaudavelspotify Apple Podcasts: http://bit.ly/rebeliaosaudavelapplepodcasts Amazon: https://bit.ly/rebeliaosaudavelamazon Deezer: https://bit.ly/rebeliaosaudaveldeezer Estamos também no telegram com um grupo exclusivo que você pode participar. Lá no telegram eu consigo compartilhar materiais exclusivos que não dá para compartilhar no Instagram. Além disso, toda segunda feira às 7:00 da manhã temos a Reunião da Rebelião Saudável com a participação de Profissionais de Saúde. Na reunião discutimos assuntos relevantes a respeito de saúde e qualidade de vida. Você pode acessar o grupo no telegram em https://t.me/RebeliaoSaudavel. Se você gosta de nosso trabalho, se inscreva e divulgue nosso Canal. Essa atitude é muito importante para a Rebelião saudável e vai ajudar nosso movimento a chegar a cada vez mais pessoas.
The Government has postponed the upcoming patent referendum that was set to be held in early June alongside the local and European elections. Patent Attorney Marie Walsh of HGF discusses the implications of this latest setback on Irish businesses, start-ups and research performing organisations. The Midland Fertility Clinic is a female-led fertility clinic established to deliver personalised, high-quality fertility care and treatment for men and women in the Midlands and beyond. Founders Elizabeth Maree and Geraldine Emerson joined Ronan to discuss their journey to date. Leading by example, Kilsaran International has proudly announced the launch of two new electric concrete trucks as part of their commitment to sustainable and eco-friendly transport solutions. Ken Mulkerrins, Group Head of Innovation & Sustainability had all the details of this exciting move. Tourism Activators Mary Hensey (Offaly) and Regina Dunne (Laois) are hosting a joint public information evening April 24th in The Heritage Killenard. Mary is asking people to think big!
HGF Delivers the weekly breaches in “Whose Been Popped?” Oracle's macOS 14.4 Java hiccup, the ever-adapting landscape of ransomware warfare, the emerging threat of Loop DoS attacks, and the Biden-Harris administration's call to action for water sector cybersecurity. Original URLs: https://www.bleepingcomputer.com/news/apple/oracle-warns-that-macos-144-update-breaks-java-on-apple-cpus/ https://www.guidepointsecurity.com/blog/t-o-x-i-n-b-i-o-ransomware-recruitment-efforts-following-law-enforcement-disruption/ https://www.helpnetsecurity.com/2024/03/20/raas-recruit-affiliates/ https://thehackernews.com/2024/03/new-loop-dos-attack-impacts-hundreds-of.html https://cispa.de/en/loop-dos https://www.epa.gov/newsreleases/biden-harris-administration-engages-states-safeguarding-water-sector-infrastructure https://www.cybersecuritydive.com/news/warnings-state-linked-cyber-threats-water/710834/ Thanks to Jered Jones for providing the music for this episode. https://www.jeredjones.com/ Logo Design by https://www.zackgraber.com/ macOS 14.4, Java Issues, Oracle Warning, Ransomware Wars, Law Enforcement, Cybersecurity, Loop DoS Attack, Water Sector Cyber Threats, Biden-Harris Administration, Cyberattack Prevention, Mobile Security, Password Managers, Apple Silicon CPUs Search Phrases: macOS 14.4 Java problems Oracle advice on macOS update Ransomware recruitment post-crackdown Effects of law enforcement on ransomware Understanding Loop DoS attacks Cyber threats to water infrastructure Biden-Harris cyber security efforts Protecting against cyberattacks in the water sector How ransomware groups adapt Cybersecurity measures for water systems Impact of macOS updates on Java Dealing with ransomware wars New cybersecurity threats 2024 Administration's response to cybersecurity in infrastructure Cybersecurity tips for protecting critical infrastructure Transcript: mar 21 [00:00:00] offsetkeyz: welcome back to the Daily Decrypt. Today, we're joined by HotGirlFarmer, as she delivers last week's breaches in your favorite segment, Who's Been Popped. Also, the company Oracle alerts customers that the new Mac OS 14. 4 update will disrupt Java functionality and urges. Customers to postpone this update. Ransomware as a Service groups are upping their recruitment efforts, defying law enforcement disruptions. With cunning resilience. What are ransomware as a service groups and how are they recruiting? Stick around to find out. And the White House is really doubling down on water utilities, urging states and governors to collaborate to help protect this critical infrastructure. And finally, researchers have discovered a new loop denial of service attack that targets [00:01:00] UDP based application level protocols, putting an estimated 300, internet hosts at risk for continuous looping and unneeded stress. How will this affect everyday users? Alrighty, so before we get into the breaches with Hot Girl Farmer, I just wanted to warn macOS users to maybe postpone the most recent update to avoid any system disruptions. There are no current workarounds and Java isn't liking the new update. This isn't like how it used to be in the earlier 2000s where Java ran everything on your computer. It shouldn't affect you unless you're developing in Java. But besides Java issues, Updated users are reporting issues with their printer drivers, lost iCloud files, and connectivity issues with USB hubs and monitors. So let's just hold off on the new macOS 14. 4 upgrade for a few more days. [00:01:53] HGF: [00:02:00] First off, hackers targeted MediaWorks, a company in New Zealand, demanding a ransom in cryptocurrency from victims who just wanted to win a free radio contest. MediaWorks is out here like, sorry, your name, address, and birthday were part of our grand prize giveaway to some hackers. Hopping on a financial rollercoaster, the International Monetary Fund got their emails hacked. And these weren't just any emails, they were the kind that you use fancy words in hoping to sound smart. The IMF is like the person who insists on using a $10 word when a $1 word will do, and now everyone knows they've been using "Synergy" wrong this whole time. [00:02:41] HGF: Meanwhile in France, they've turned data breaches into an art form, with up to 43 million people affected. It's a breach so chic, it's practically wearing a striped shirt and smoking a cigarette. And let's not forget Alabama, where the state government websites faced a denial of service [00:03:00] attack. Alabama's like, Our websites are slower than molasses in January, but don't you worry, your data's as safe as a church potluck. Except in this case, the potluck's been crashed by every hacker in a 10 mile radius. So, what have we learned aside from the fact that the world is a hacker's oyster? Keep your friends close, your passwords closer, and maybe, try not to store your entire life on a device that could be hacked by a 12 year old with a grudge. In the grand scheme of things, we're all just trying to make it through this digital world. [00:03:32] transition: Thanks for watching! [00:03:38] offsetkeyz: We've been hearing a lot coming out of the White House about critical infrastructure, such as power and water. They've been providing a lot of guidance recently and encouraging collaboration to avoid cyber attacks. So what do they know that we don't know? It's starting to get me a little scared. So just two days ago, the Biden Harris administration released some more guidance on how to stay safe, but is [00:04:00] also urgently calling governors and state governments to start collaborating. and really hardening the systems of their critical water infrastructure. When we think about crippling cyber threats, we tend to think about big corporations and ransomware and things like that, but those may be where the money is, but those who are out to get the United States of America, like maybe China and maybe Russia, I'm not sure. We'll be targeting our critical infrastructure first Now, if you are working in it in a critical infrastructure like power or water, our hats are off to you. I know what you're up against and even. The White House knows what you're up against, which is why they're starting to step in. So keep doing the Lord's work out there and try to get it as secure as possible. Because, hey, we all need water to live. And I don't want to be making that Walmart run when my water stops working. That's going to be crazy. So part of the major efforts by the Biden Harris administration includes creating a cybersecurity task force between the EPA and the [00:05:00] NSC, promoting existing resources to protect against cyberattacks on water systems. According to the letter from the White House, there have been an increased amount of attacks on water systems driven by both countries or nation state actors and run of the mill cyber criminals. So I'm glad to see our federal government stepping in and helping where they can. But we might be reaching the point where we need to take our own health and wellbeing into our own hands, stock up on water, buy a nice filter, maybe get a rain bucket for outside. Make sure that you and your family are taken care of in the event that the water does go down. [00:05:40] offsetkeyz: Recently we've been seeing a lot of ransomware as a service groups being shut down by the FBI and other three letter organizations, which is great. But the FBI can only do so much, and what they've been doing is trying to capture individuals who are responsible for running these ransomware as a service groups or developers, [00:06:00] but mostly they're just shutting down dark web websites. with big banners that say claimed by the FBI. So in most instances, the individuals behind these ransomware as a service groups are just moving and creating new ransomware as a service groups, or joining others, strengthening their staffing. But let's back up for a second. What is ransomware as a service? Well, this is the new hot thing in ransomware, where it's essentially Cloud as a service, or something that you would sign up to use not really knowing how to make it yourself, but you want to use the tools to conduct a ransomware. So a good example of something you might use as a service is something like Squarespace, where if you don't know how to do web development, but you want a website, you would then pay for Squarespace's services and they give you some features, right? Depending on how much you're willing to pay. So Squarespace specifically is considered software as a service. Now ransomware as a service does exactly [00:07:00] that. I would like to ransomware somebody. So I go sign up for an account at one of these places. Such as Medusa or Cloak, as referenced in the article by HelpNet Security that's linked in our show notes below. And depending on the amount you want to pay for this service, you can get perks. Thanks. The amounts are surprisingly low between 800 to 1, 000 a year to access this product and they're getting lower. They're being pushed harder onto end users and the perks are getting better too. One of the lowest tiers is once you reach a million dollars in ransom payments, you get access to dumped hashes, you get access to a bunch of tools that make it easier to do the initial compromise. There have also been a string of Exit scams across the dark web, which is essentially when a company like Medusa or any ransomware as a service will Receive the ransom that you [00:08:00] went out and earned and then just close down their site keeping all of the money most ransomware as a services Set up the platform to receive the money And then they pay you about 85 percent of the ransom, as agreed upon before using the service. But now these groups are starting to let you collect the ransom, and then allow you to pay that 15 percent usage fee. helping to encourage people to use their services and not be so afraid of exit scams or other scams on the dark web. But what's so crazy about this is that they're literally just posting ads on the dark web. They're in forums and they are offering these perks and security researchers are able to see them in real time and see who's interacting with them. And the beauty of the dark web is that. If you're doing it correctly, it can be completely anonymous. Now I don't encourage you to get on the dark web to see this type of activity, but it is available to you. And if you'd like more information about the dark web, I released a talk about a week ago, maybe two weeks ago at this point, outlining at a high level how the dark web [00:09:00] works. [00:09:12] offsetkeyz: And finally, researchers have developed or discovered a new denial of service or DOS attack. that relies on UDP based application level protocols. And if you're not familiar, there are two main protocols on the transport layer that you interact with on a daily basis. UDP and TCP. UDP is the faster of the two, and it doesn't require any sort of verification that the data has been received. And this is often used when gaming online with your friends or talking, or even streaming like YouTube videos. Those rely heavily on UDP because you need to get the data as quickly as possible when streaming videos. And it doesn't really matter if every single frame is accounted for, you can occasionally drop frames, which might result in a little skip, but [00:10:00] overall, most of them are going to get through kind of like a shotgun spray. Whereas TCP is more for like text based communications or things where data needs to be verified on both ends, and it's a little slower due to the verification. So, UDP inherently doesn't verify, which is important to understand this type of attack, because this loop denial of service exploits UDP's lack of source IP validation to create endless communication loops between servers, eventually overwhelming them. Additionally, protocols like DNS, NTP, and TFTP are among those vulnerable to these attacks, potentially affecting basic internet functionalities. So this does tie back into the attack on DNS, which is essentially like a lookup of what you're trying to navigate to. So, when you navigate to facebook.com it reaches out to a DNS server and says, Hey, what the heck is facebook. com? And it replies with an address. Without those [00:11:00] DNS servers, we actually can't move about the internet like we do on the day to day. So this attack is easily triggered by a single spoofed message and can stress entire networks with 300, 000 hosts already at risk. There's no evidence of this loop denial of service being used in the wild, but its exploitation is considered trivial, affecting major vendors like Cisco and Microsoft. Now, these are likely a little further down the pipeline than you're familiar with as a regular user or even as a cybersecurity analyst. but you might notice slower internet speeds, stuff like that, if this happens, with the potential for it to completely shut down your internet connection. And on that note, not much is to be done on the user level. Just letting you know what's possible and what the attackers are doing. Hitting you from all kinds of angles. All right, and that is all we've got for you today. A little bit longer of an episode because we missed yesterday due to technical [00:12:00] issues, but we're back and better than ever, and we will talk to you some more tomorrow.
In today's episode, join offsetkeyz and guest Hot Girl Farmer as we delve into the complexities of Texas's new Age Verification Law (HB 1181) and PH's bold response. We explore the implications for privacy, data security, and censorship, bringing to light the challenges and debates sparked by this legislation. Discover insights from key sources, including the official Texas bill, critical analysis from the Washington Post, and research on the claims surrounding adult content and public health. Texas Bill HB 1181: https://capitol.texas.gov/tlodocs/88R/billtext/html/HB01181H.htm Scrubs Reference: https://youtu.be/c_o8vYUU-jo?si=MEqNmvs32MBeltI5 Washington Post Article: https://www.washingtonpost.com/nation/2024/03/15/pornhub-texas-age-verification-law/ Public Health Claims Analysis: https://ajph.aphapublications.org/doi/10.2105/AJPH.2019.305498 Texas Age Verification Law, PH, privacy, data security, censorship, Hot Girl Farmer, HB 1181, digital rights, adult content regulation, podcast episode, legal challenges, public health claims Search Phrases: Texas Age Verification Law podcast PH response to Texas law HB 1181 implications and discussion Privacy and censorship in digital age podcast Understanding Texas's adult content regulation Legal challenges to age verification laws podcast Exploring PH's stand against Texas law Public health claims against adult content podcast episode Data security concerns in age verification laws Transcript: Pornhub Episode [00:00:00] offsetkeyz: Alright, welcome back to the Daily Decrypt. Today we're joined by Hot Girl Farmer, and we're just covering one topic, the Texas Age Verification Law that passed back in June, and P.0.r.N.HU8's response. Now, this topic is vast and covers a lot of facets that the Daily Decrypt and its audience are interested in, such as data protection, such as censorship, all of these things. And so we're just going to be focusing on this one topic for the whole episode. And though it does revolve around P.0.r.N.HU8 as a company which inherently involves adult content, we won't be going into any sort of graphic detail or anything like that. There may be mention of certain things that go on on this website, but nothing too crazy. But if you're sensitive to The type of content P.0.r.N.HU8 provides, it might be in your best interest to skip this episode. Though we don't encourage it because it's going to be pretty juicy. [00:01:00] Okay, so on June 6th of last year, Texas Governor [00:01:07] offsetkeyz: Greg Abbott signed into law a requirement that any website that displays adult content must verify the consumer's age before they can see the content. So that was, what, nine, ten months ago? Which, [00:01:23] HGF: immediately I thought of when you go to an alcohol website and it asks you for your birthday. So I was like, oh, verification would be good. And nobody wants children to view P.0.r.N.Ography, literally no one wants that. And I would think most people also think it's best to be consumed over the age of 18. I was like, okay, I don't really understand the controversy yet. I feel like people can get on board with verifying your birthday. [00:01:48] offsetkeyz: Right, and if it was just that enter your birthday verification style, It might not be as big of an issue, but the law itself required more stringent data [00:02:00] verification, such as entering in your data on a third party site that then verifies your identity, but you know what data they require. We're not entirely sure or entering in a credit card number or entering in information from your mortgage or like very. poking and prodding for this data. So that was signed into law. Immediately a group of plaintiffs, one of which was P.0.r.N.HU8, sued the state of Texas for censorship. Fine. Just last week, the state of Texas and the Fifth Circuit sided with the law that Governor Greg Abbott put into place requiring age verification. And so P.0.r.N.HU8 decided to take its service offline in the state of Texas as a protest. P.0.r.N.HU8. is not against age verification. So I'm just going to get that out of the way up front. P.0.r.N.HU8 is very pro age verification, but they're pro age verification in ways that make sense and don't [00:03:00] censor users and don't hurt people. Don't put people's data at risk. They want it to be a streamlined process. They want it to at least be accurate. know, At this point, it's more of a formality than it is an accurate way of verifying age. [00:03:15] HGF: Yeah, the methods that were available were not potentially secure or divulge too much information. Like a lot of personal private data from a third party site, right? [00:03:25] offsetkeyz: Right. And you can imagine that if you are someone of the age that should not be consuming adult content, which I believe is anyone under 18 across the country? I'm a little older than 18, uh, so I don't really know firsthand. Doesn't affect me, I don't have kids, but I don't know. You could get your parent's credit card and enter it in. There's not going to be any charges. It's just a verification method. You could go into your parent's filing cabinet and get your parent's mortgage. You could get the deed to their house and enter in [00:04:00] information off of that. You could go sneak out and grab your parent's driver's license, which is another form of verification that they're allowing, which all you have to do is enter in your driver's license number. And you're verified. Not only is this method unsafe, for reasons we'll get into shortly, but it's not accurate. And that is what P.0.r.N.HU8 is protesting. Not age verification. I just want to be very clear about that, that regardless of whether or not you, agree with P.0.r.N.HU8 fundamentally for what it does. It is my opinion that they're not doing anything malicious by protesting age verification laws. They are pro age verification, anti this method. [00:04:43] HGF: Yeah. And, yeah. this is just not a good barrier to entry. I can totally see minors like in a group chat being like, this is the driver's license number I use. So I think this would lead to a lot more of your data being stolen and [00:05:00] misused by minors to gain access. It just, I'm not extremely familiar with the verification methods that, Texas is wanting to see, but I think it would lead to, more data theft. Of adults to minors. Like if I was still teaching in high schools, I would be so, I don't think I'd bring my ID in the building just because I wouldn't want them to look at it. And I mean, kids, kids will do anything to do what they want to do [00:05:26] offsetkeyz: Of course. Yeah, they know you have a driver's license, you drove to work, they know it's probably in your purse. They know you're walking around the classroom. So like they have if someone wants to find an adult's driver's license this law only encourages crime. It's not put in place to protect the safety of minors, though that's how it's masquerading. It's actually trying to remove P.0.r.N.Ography from the internet, which is a crime. Censorship. Regardless of how you feel about P.0.r.N.Ography, removing [00:06:00] P.0.r.N.Ography from the internet is censorship, and we don't stand for censorship. And if the P.0.r.N.Ography is requiring driver's licenses, the value of driver's licenses has gone up, encouraging crime. [00:06:13] HGF: This is just getting so in the weeds. This is just creating so many, this is opening a can of worms of issues that we are not prepared for, and the creativity it'll take and the different avenues people will get information they need to log in. I don't even think we can conceptualize it yet. So, good on P.0.r.N.HU8 for taking a stand and pulling their site from Texas. They're like, [00:06:35] offsetkeyz: They're [00:06:36] HGF: this is too much. We're not dealing with this. [00:06:38] offsetkeyz: 100 percent and yeah, we don't want an official stance to be that we stand with P.0.r.N.HU8, but we do agree with what they're doing in this avenue. [00:06:47] HGF: Anyone that takes user data seriously, we stand with, yeah, in that instance. [00:06:55] offsetkeyz: If you're going to enable age verification, make sure that it actually [00:07:00] verifies the age of the consumers. So, what P.0.r.N.HU8 is proposing, and what they've been proposing for years and years and years, is what's called device based age verification. Most people, at least in first world countries, like, United States and Canada and Europe and I don't know, have a device that's tied to their identity, whether that be a phone, whether that be an iPad, whether that be a laptop. And imagine if Your iPhone when you turned it on, verified what age you are. You only have to do that once and all that data stayed on your phone. It didn't go to the cloud. Yeah, it stayed on your phone, which you own. But using signatures and verification methods, your iPhone could then communicate just your age, which has been verified to you. to the site saying, Hey, yeah, this person is actually such and such age. And that's all they're, that's all they're going for. They [00:08:00] want to make sure that when age verification is implemented, it's implemented to actually verify the user's age. [00:08:05] HGF: Yeah, I think this is an issue left up to parental controls and just different [00:08:11] offsetkeyz: methods [00:08:12] HGF: methods within the device itself, and it creates a whole host of problems when we have that transferred over to third party identifying platforms. [00:08:24] offsetkeyz: The other main issue with this is that Texas is allowing for third party sites to step in and verify people's age. So, sounds great on the surface, but what it actually is, is you're just giving your data to more sites. There are very reputable sites out there that keep your data, quote, secure. id. me is one that comes to mind. That's to verify your entire identity, and it requires you to enter in a lot of information. your social security number, your driver's license number, credit cards, former addresses, all [00:09:00] kinds of data that is now with some third party site. First of all, P.0.r.N.HU8 users probably don't want their entire identity linked to their P.0.r.N.HU8 account. And nor should it be! It's just videos. It's is your whole identity linked to your YouTube account? Maybe, but should it be? Doesn't matter. I should be able to log onto YouTube and just look at things. That also increases the risk of that data being captured by the wrong people. The more you enter in these sensitive pieces of data across the internet, the risk increases exponentially with every site. And so with giving third parties this power to verify ages, opens up the door for scams. Right? Especially In the nature of the product that P.0.r.N.HU8 offers, there's somewhat of a sense of urgency when consuming it. And now all of a sudden you have to go to this third party site to [00:10:00] verify your age. So maybe you go to Google and you say age verification site, and you type that in. And the first thing that comes up is an ad for an age verification site. that looks good. And so you go to that, it says, yes, compatible with P.0.r.N.HU8. You enter in your social security number. And hey, turns out that was a scam site, but you were moving so quickly that you just went right for it. And you might not even notice that was a scam site. You might just be like, okay, it's not working. Let me try another site. And you might just keep going down the line until one works. You don't want to be haphazardly handling this type of data because it can end very poorly. [00:10:37] HGF: Yeah, people aren't in the frame of mind to be just extremely discerning. [00:10:43] offsetkeyz: Right. I'm trying to think of an example of something else where this might be the case. Like alcohol. [00:10:50] HGF: hungry. Ooh, when you're really hungry. She [00:10:53] offsetkeyz: she resonates with the gong of the Taco Bell. Fourth meal is very prevalent here in our [00:11:00] household. [00:11:00] HGF: If I'm hungry, it's just like, DoorDash, order here, 3 off, da da da da da. I'm just typing in whatever. I'm hungry. Anything your human desire is being driven to act. you're just not taking precautionary steps. [00:11:15] offsetkeyz: Great example so I know certain individuals don't have DoorDash, they've never used DoorDash, and they've always been able to find their food when they need it. But say they run into a situation in a snowstorm, and they have a flat tire, and they go download, or they go to Google and they search for DoorDash and they're trying to get someone to deliver them food and what they get is an ad that is not actually DoorDash. They sign up for an account on this fake site with their address and with their phone number and with their credit card information and all this stuff only to find out that isn't actually, you know, it's that sense of urgency that really dulls your perception of these fake sites. [00:11:58] HGF: that's concerning for [00:12:00] users. But yeah, our caveman brains, the way they're wired, anything that's creating a need and sense of urgency is just, we're gonna overlook things, [00:12:13] offsetkeyz: Alright, so we've touched on a lot of how we feel about this, but I want to take a step back and read a little bit from the Washington Post's reporting on the ruling and on P.0.r.N.HU8's reaction. So this is coming from the Washington Post, likely will be one of the first search results if you even search for any of the search terms. So P.0.r.N.HU8, one of the most popular websites in the world, blocked Texas based access. To its site, one week after the conservative U. S. Court of Appeals of the Fifth Circuit upheld the age verification portion of the state law. So P.0.r.N.HU8 has previously opposed such measures in states like Utah, arguing that age gating laws are ineffective, as we discussed, unfair, and punish the very [00:13:00] users the state wants to protect. For a myriad of reasons, right? And we've touched on a few. But it can harm people in so many different ways. Let's keep reading. Texas Attorney General Ken Paxton called the decision a victory over P.0.r.N. Companies and denied the state's law violates free speech laws, but free expression advocates, including those in the adult content industry, Warned that laws like the one in Texas are being weaponized to censor a variety of content, including reproductive rights, resources, and queer literature. [00:13:33] HGF: That's what I was saying. [00:13:35] offsetkeyz: It is reminding me a little bit of what's going on with TikTok as well. The fact that we can ban a content streaming platform because it's owners are from a different country is crazy. And hey, actually turns out we can't ban a content platform. We literally cannot do that. All we can do is place laws on other areas around it. So the [00:14:00] same tactics are being taken with age verification in Texas as they are with TikTok across the country, as they are with Things like abortion, like, hey, we might be able, might not be able to ban abortion, but we can find the crap out of doctors who perform it. [00:14:15] HGF: Yeah. Overarching, all of those have themes of some sort of censorship. In June, Texas Governor Greg Abbott signed into law HB1181, a bipartisan bill requiring companies that offer sexual material harmful to minors verify that its users are at least 18 years old. Companies that need to limit minors access, such as websites for liquor brands, commonly use age gating methods such as requiring a user to list their birthday. Texas's law required users to prove their age by either entering information from a government issued ID or using a third party system that uses public and private data such as employment, education, or mortgage information to verify age. [00:14:56] offsetkeyz: [00:15:00] of data that people can use to verify their age. They can use anything, any document laying around their parent's house to verify their age. Cool, very effective guys. [00:15:13] HGF: This is also, this might be getting too into the weeds and not as cyber security related, but I'm just curious. I need to look at this more. How many studies do we have showing that it causes irreparable harm to people's psyche? Like it says that right here, it says, HB 1181 also required P.0.r.N. Sites to display a controversial health warning, which the law's opponents called pseudoscientific and included language like Texas Health and Human Services Warning. P.0.r.N.Ography increases the demand for prostitution, child exploitation, and child P. It says that in the warning. Do we have the data to back that up? That it's a gateway to other illicit sexual consumption? Jen? [00:15:55] offsetkeyz: skeptical [00:15:55] HGF: I'm a little bit skeptical that we have data that P.0.r.N.Ography increases [00:16:00] the demand for child p. pornography. more you work with data, the more you realize that you can make this type of data look however you want it to look, but when it comes down to it, P.0.r.N.Ography is adjacent to child [00:16:13] offsetkeyz: p sexual crimes, and sexual crimes are adjacent. You know, Child p is a subset of P.0.r.N.Ography and without P.0.r.N.Ography, there's no demand for child p. It reminds me of a joke. I'm trying to remember who said it. But the joke is, I think it's Scrubs. Oh boy, [00:16:37] HGF: Oh [00:16:37] offsetkeyz: I'm back on scrubs Dr. Cox is talking about how They're trying to ban P.0.r.N.Ography from the web, and if they do ban P.0.r.N.Ography, there will only be one website left, and it will be called Bring Back the P.0.r.N.Ography. Regardless of whether or not we ban P.0.r.N.Ography, there's gonna be a demand for it. [00:16:57] HGF: Yeah. I bet you could skew [00:17:00] data to say that without it there's increased violence toward women. [00:17:04] offsetkeyz: Mm hmm. [00:17:06] HGF: hmm. Like, the repression creates more issues. I just think that you can skew data any way you like. I'm very skeptical that there's a verified study that Consuming content on P.0.r.N.HU8 increases demand for child p. pornography. [00:17:23] offsetkeyz: Mm hmm. [00:17:23] HGF: That's wild. That, the [00:17:25] offsetkeyz: they surveying? [00:17:26] HGF: the state is just publishing that. It's not citing, in the warning, it's not citing any specific clinical trials or studies. I just feel like we're, the age of the internet, we have access to a lot. We have access to a lot of information and articles. And it's hard to be discerning what's true or what's not, and that's why we really need to rely on peer reviewed, verified, studied information. [00:17:55] offsetkeyz: We do. Our little lizard brains are likely to believe whatever we [00:18:00] hear. And so we're going to do our part on this podcast and drop a lot of links in the show notes below, and we really encourage you to go in and read them for yourselves, not just believe what we're saying on this podcast. If you keep reading Hot Girl Farmer, you will see that the court, the Fifth Circuit, uh, of appeals denied the health label. So, So they sided with requiring age verification, but they did deny forcing adult websites to have this health label on them. Thank goodness, probably for the reasons that you mentioned, but we will verify that in the show notes as well. [00:18:39] HGF: Okay. Well, that's good. [00:18:40] offsetkeyz: I wonder, I You can spin anything, any way you want. There was another comedian that I watched the other day because of daylight savings time. [00:18:52] HGF: Yikes! Yeah, it's been kicking my ass. [00:18:54] offsetkeyz: Where, It's all about how you spin it, right? If the government came on and they're like, Hey, you're going to actually have to be at work an [00:19:00] hour earlier tomorrow, and you're going to have to wake up an hour earlier. It's going to be dark, and it's going to be light when you try to go to bed, like all these things. Everyone would be like, no, but instead the government's just like, Hey, you know what? Just once a year, we think it'd be cute if we just set our clocks back an hour. Everyone's like, I guess. Yeah, sounds great. So the attorney general is saying. This is a victory, but imagine if P.0.r.N.HU8 had an office in San Antonio, the capital of Texas, that employed 100, 000 people. Imagine that! Now all those people are out of a job! Is that a victory? You're, yeah. You're actually shutting down jobs for one of the top websites on the internet. Like Facebook is up there, Google's up there, and P.0.r.N.HU8 is up there, and you are shutting down jobs. Doesn't sound like a victory to me, governor. [00:19:55] HGF: Yeah, it just is from what angle is this a victory? With the ease of use of VPNs, [00:20:00] I, most people know how to use them and get around this age verification anyway. So I would say people that, that want to go on the site can still go on the site. You have to be like 2 percent tech savvy to use the VPN. And then I still think it's going to encourage minors to commit data theft. And so I wouldn't really call this a victory, , if you're against. this site. [00:20:24] offsetkeyz: Yeah, instead maybe work with them. They have really good ideas and they have a lot of resources to implement those ideas. They have a lot of money, and so if P.0.r.N.HU8 is willing to work with the state of Texas to develop state of the art proprietary age verification methods, why not do that? You're like actually saying no to innovation. Where you could have maybe a patent tied to your name that helps keep P.0.r.N. Out, like actually helps keep P.0.r.N. Out of the eyes of minors, but instead you're just encouraging lying, cheating, and stealing new dark [00:21:00] markets to pop up so maybe think about that. [00:21:02] HGF: This is a weird haphazard band aid that just creates more problems. This is not the solution that they're looking for. And again, no one wants miners to consume this. And I just, we really think that age verification on the device itself is secure and a good way to go. [00:21:21] offsetkeyz: Absolutely, and P.0.r.N.HU8 does not disagree either. [00:21:36] offsetkeyz: So we've covered a lot. Of our thoughts and our feelings, as well as what's actually happening in the state of Texas and with the state of P.0.r.N.HU8 and censorship and data laws. And just to recap, I want to go over what happened again timeline wise, but there was one more point that the Washington Post article makes, [00:22:00] and that is that P.0.r.N.HU8 is potentially the most reputable of sites to consume adult content. They take the privacy of not only the creators, but the users very seriously. They take complaints very seriously. They're not, they're filtering out their content so that nothing illegal is on there. They're doing a lot of good things. They're making sure that when you watch these videos, there's no way for bad actors to embed malware. They have firewalls. They have anti malware. Like I said, they have all these protections because they're the most reputable of sites. So now these measures have caused P.0.r.N.HU8 to take their services off. Offline in Texas, but what are people who are seeking adult content going to do from there? They're going to go look for other websites that maybe aren't as reputable. Maybe have more sketchy content because it's not being filtered like child p or a [00:23:00] list of other kinds of things and might be laden with malware or downloadable whatever. Like if you click on a link in one of these sites maybe it redirects quickly to something and you're infected. Making these requirements are only fiscally achievable by companies that have the resources to achieve them. Like the age verification is what I'm talking about here. P.0.r.N.HU8, I don't know any other reputable sites, but they would all have the means to implement these things. So, people who are blocked by age verification will now start going to sites that don't have the means to implement age verification. And those sites are much more likely to have malware and lurkers and inappropriate content. So thanks to the Washington Post, they, I mean, they didn't bring up all that, but they brought up a little bit of it. So thanks for bringing up that point. There's just, where's the good? [00:23:55] HGF: Yeah. [00:23:56] offsetkeyz: All I see is bad. [00:23:57] HGF: We get what they're going for, but [00:24:00] this is just not achieving that at all, unfortunately. [00:24:02] offsetkeyz: And it's actually a step in the wrong direction. So any of my Texas people who back this bill, you might think it's a step in the right direction, even if it's not solving all the problems, it's actually a step in the wrong direction due to all the reasons listed in this episode, is a step backwards. So you're actually shooting yourself in the foot. So just to recap, in June, Texas passed a law requiring any website that displays adult content to be disabled. Verify the consumer's age using pretty in depth methods, not just enter in your birthday like they do on liquor sites. A bunch of people, P.0.r.N.HU8 one of them, sues the state of Texas over censorship laws. Just last week, the courts in Texas sided with the state of Texas and P.0.r.N.HU8, in reaction to this ruling, pulled their services from the state of Texas. You can no longer access the website P.0.r.N.HU8 in the state of Texas. P.0.r.N.HU8 is pro age verification. They are very for [00:25:00] it, but they want it to actually verify age and not just attempt to censor content. And we think that the state of Texas, the government of the United States, should work with companies like this to implement effective age verification using any method. This is where creativity comes into play. We need to find a method that will effectively verify users age, not just verify that they have access to documents that verify somebody's age. And they need to work together to make sure That's what's implemented. Not taking these half assed, band aid approaches that actually hurt the people they're trying to protect. [00:25:39] HGF: Yeah, thank you guys for tuning in with us to discuss this pretty controversial, really interesting topic. This is really interesting to us. There's a lot of nuance in here. There's a lot of gray area, which is something that I enjoy to discuss. And so thanks for sticking with us, keeping an open mind, and just, we're just trying to focus on the [00:26:00] facts, the law, what's going on, and keeping you guys up to date with cyber news. And this one just came up and feels pretty pressing to discuss. [00:26:08] offsetkeyz: There's definitely some other things in the news that we're going to touch on tomorrow, but yeah, thank you for giving us the opportunity to talk about this. We threw a lot at you and that is just to get thinking about reasons this bill might be good or this bill might be bad. Whatever, you are entitled to making your own opinion. Again, we encourage you to check out the resources we're providing in the show notes and to think for yourself. Thanks so much for listening to the Daily Decrypt. Thanks for Hot Girl Farmer for being here on this, and we will talk to you some more tomorrow. [00:26:36] HGF: See you guys. [00:27:00] [00:28:00]
Today, we uncover a Roblox malware scam, explore the rise of FakeBat through malvertising, and highlight Tor's innovative WebTunnel for evading censorship. From the playful realms of Roblox to the frontlines of digital freedom with Tor, this episode is a journey through the evolving challenges and solutions in our online world. Protect your digital footprint and join the conversation on cybersecurity, privacy, and the relentless quest for a free internet. Article URLs: Roblox: https://www.zscaler.com/blogs/security-research/tweaks-stealer-targets-roblox-users-through-youtube-and-discord FakeBat: https://www.malwarebytes.com/blog/threat-intelligence/2024/03/fakebat-delivered-via-several-active-malvertising-campaigns TOR: https://www.bleepingcomputer.com/news/security/tors-new-webtunnel-bridges-mimic-https-traffic-to-evade-censorship/ Thanks to Jered Jones for providing the music for this episode. https://www.jeredjones.com/ Logo Design by https://www.zackgraber.com/ Tags: Roblox, malware, cybersecurity, digital privacy, FakeBat, malvertising, Tor, WebTunnel, online security, internet censorship, gaming, digital rights, data protection, hacking, antivirus Search Phrases: How to protect against Roblox malware Understanding malvertising and FakeBat malware Tor's WebTunnel for bypassing internet censorship Latest cybersecurity threats 2024 Safe gaming practices for parents and children Fighting digital surveillance and censorship Effective antivirus and malware protection tips Digital privacy concerns in online platforms Strategies for secure internet browsing Overcoming hacking in gaming communities Enhancements in Tor for secure communication Detecting and preventing online ad-based malware Innovations in digital privacy and security Techniques for safeguarding personal data online Analysis of current cyber threats and solutions Transcript: Mar 14 [00:00:00] offsetkeyz: A nefarious malware targets Roblox users, tricking them with the false promise of enhanced gameplay, only to steal personal information. [00:00:12] HGF: Fake bat malware leaps from the shadows of online ads, preying on unsuspecting victims with the disguise of legitimacy. [00:00:20] offsetkeyz: Tor Project unveils WebTunnel, a masterstroke in digital disguise. Outmaneuvering censorship with a stealthy sophistication. In the digital playground of Roblox, a new villain lurks. Not in the game, but in the guise of a performance boost. [00:00:42] HGF: Oh, Roblox, where my niece says she's gonna be the next digital Picasso. But really, what is it? Just a bunch of blocky characters bumping into each other? [00:00:50] offsetkeyz: It's more than that. Roblox is a sprawling online platform that lets users design, play, and share their own games and experiences. Think of it as [00:01:00] a digital Lego set, but with infinite pieces and possibilities. [00:01:04] HGF: Infinite pieces? You're saying if I wanted to build a castle with a moat filled with laser sharks, I could? Mmm, [00:01:11] offsetkeyz: sharky. Absolutely! Roblox provides the tools and the canvas. Your imagination brings it to life! Roblox It's powered by a robust game development system that lets creators script events, design levels, and even monetize their creations. [00:01:27] HGF: Monetize? So kids are making bank on this? My lemonade stand suddenly seems less impressive. [00:01:34] offsetkeyz: Yep, gone of the days of lemonade stands. Some developers on Roblox earn serious money through in game purchases using a virtual currency called Robux. It's a whole economy. Roblox is a vibrant community with millions of user generated games. There's something for everyone, from obstacle courses and simulators, to role playing games and beyond. But here's the twist. Discovered by Zscaler's Threat [00:02:00] Labs, attackers are exploiting platforms like YouTube and Discord to distribute a malware called Tweaks, or Tweaker. It promises to optimize your frames per second, but instead it's a one way ticket to Hacksville. So, [00:02:15] HGF: it's like ordering a performance enhancing smoothie but ending up with a bellyache that steals your wallet? [00:02:21] offsetkeyz: Oh yeah, there are tummyache survivors out there. But this PowerShell based malware silently siphons off sensitive data. Think Wi Fi passwords, location, Roblox IDs, and even in game currency. Like [00:02:35] HGF: a digital pickpocket. But wait, PowerShell? Is that like a superhero power? [00:02:40] offsetkeyz: Quite. PowerShell is a scripting language for Windows, often used by system administrators for automation, but in our villain's hands, it becomes a tool for theft. [00:02:51] HGF: I see, so they're using PowerShell for evil. Got it. How bad is this [00:02:57] offsetkeyz: breach? Given Roblox's [00:03:00] massive user base, where 45 percent are under 13, the scale is concerning. It's not just gamers at risk, it's potentially their parents and even corporations, thanks to remote work blurring the lines between personal and professional devices. [00:03:15] HGF: Yikes, so my quest for smoother gameplay could put dad's spreadsheets in jeopardy? [00:03:21] offsetkeyz: Precisely! The attackers cleverly disguised their malicious intent, using legitimate looking videos and discord communities to spread tweaks. They even offer a free version to lure users into their trap. Free? [00:03:36] HGF: Sounds like the only thing free about it is the trip to hackerland. What can the good folks at home do to protect themselves? [00:03:43] offsetkeyz: The golden rule is stick to reputable sources for game enhancements, avoid disabling antivirus software for dubious downloads, and maintain skepticism towards too good to be true offers on social platforms. Got [00:03:57] HGF: it. Keep it legit or risk a cyber hit. [00:04:00] Any word from the digital knights at Zscaler? [00:04:03] offsetkeyz: Zscaler's Threat Labs is on the front line. Their sandbox technology uncovering the murky tactics and techniques of this malware campaign. It's a reminder of the constant cat and mouse game in cyber security. [00:04:15] HGF: So the moral of the story, if an FPS booth sounds too good to be true on Discord or YouTube, it probably is. [00:04:29] offsetkeyz: February saw a surge in search based malvertising. with Fakebat leading the charge. A cunning malware distributed through ads for popular software, which was reported by Malwarebytes on Tuesday. See the link in the show notes. [00:04:44] HGF: Fakebat? That sounds like a villain from a Saturday morning cartoon. So what, now I can't even click on things I search for with [00:04:51] offsetkeyz: Google? Remember, if you're searching for something specific, try not to click on the advertisement results. Anyone can buy these advertisement [00:05:00] spaces, and trick you into clicking them by impersonating the site you're trying to find. This malware has been impersonating brands like Parsec and FreeCAD. Both are cutting edge technologies in their respective fields. Like a wolf in sheep's [00:05:14] HGF: clothing. How do they even get these ads in front of people? [00:05:18] offsetkeyz: malvertising campaign gets creative., They've leveraged URL shorteners and even compromised legitimate websites, making these malicious ads appear trustworthy. Victims are lured into clicking, which kicks off a redirect chain ending in malware installation. Once installed, Fakebat reaches out to its command and control servers, putting victims data at risk. So, what's [00:05:41] HGF: the digital equivalent of locking our doors and windows? [00:05:44] offsetkeyz: The key is caution. Avoid clicking on ads for software downloads, and ensure your system's security measures are up to date. Utilizing tools like Threat Down DNS Filter can block malicious ads at the source, offering a layer [00:06:00] of protection. Got [00:06:01] HGF: it. Be skeptical of too good to be true ads and maybe invest in a cyber guard dog. How is Google dealing with this ad [00:06:09] offsetkeyz: apocalypse? The incidents have been reported to Google, highlighting the ongoing battle between security researchers and malvertisers. It's a digital cat and mouse game. with each side constantly evolving their strategies. [00:06:23] HGF: This actually happened to me when I was shopping for a pan at our place. It was like a website. I clicked on the sponsored one and it was like at our place. com and it almost got me, but the font looked a little bit off. Really? Yeah. I think I sent it to, this is like last year, but I'll never forget how identical to the site it looked, but everything was on super sale and it was like, hurry, act now. And they never do that. And I was like, Good [00:06:50] offsetkeyz: catch. I actually had a friend order shoes at my recommendation from my favorite shoe store called Vivo Barefoot. Except he went [00:07:00] and googled it, and it, the first one on Google was vivobarefootusa. com, and he actually ordered shoes from them. And never got [00:07:09] HGF: them. [00:07:10] offsetkeyz: And never [00:07:12] transition: Uh, uh, uh, uh, uh, uh. [00:07:24] offsetkeyz: The Tor Project has just unveiled their latest innovation, WebTunnel. A new bridge designed to camouflage Tor connections amidst regular HTTPS traffic, making it a formidable foe against censorship. Tor is all about privacy and overcoming digital barriers. Bridges in the Tor network are like secret pathways that aren't listed in the public directory, helping users connect without drawing attention. However, countries with tight censorship have gotten better at spotting these connections, Causes the need for WebTunnel, which disguises Tor traffic to look just like any other HTTPS web traffic.[00:08:00] This makes it much harder for these countries to block without also disrupting HTTPS connections, which are vital for a secure internet. How does this magic work? It's all about the art of disguise. WebTunnel wraps Tor's data packets in a layer that mimics WebSocket like HTTPS connections. To any observer on the network, it appears as if the user is simply visiting websites, making it difficult to distinguish and block Tor users specifically. And what about [00:08:29] HGF: those living under the watchful eye of Big Brother? Any luck for [00:08:33] offsetkeyz: them? That is the heart of the matter. WebTunnel proving to be effective in countries who govern internet usage, but some of them, like China and Iran, are figuring out ways to detect it. Tor recommends adding a layer of obfuscation using the OBFS4 protocol. [00:08:52] HGF: OBFS what? Sounds like something out of a spy novel. [00:08:56] offsetkeyz: Not far off, oBFS4, or as I like to [00:09:00] call it, the OB4 Skater, is a protocol designed to disguise internet traffic, making it difficult for third parties to determine what's being transmitted. This is crucial in places where censorship is rampant and access to information is restricted. [00:09:15] HGF: Hide and seek with your internet connection. If I'm in a country that's not too fond of free information, it's OBFS4 could be my ticket to [00:09:23] offsetkeyz: the wider world. Exactly, yeah. OBFS4 is a critical tool for those in oppressive regimes, offering a lifeline to unrestricted information. It exemplifies the ongoing battle for digital freedom, ensuring that the internet remains open and accessible to all. A lot of companies IT departments block Tor on their network. For good reason. So, the main purpose of the WebSocket is to allow citizens of oppressive regimes to Access the internet unrestricted, but I'm wondering what the implications will be for IT departments trying to detect [00:10:00] this type of traffic on their networks. It will blend in with everything else, which could open some, some floodgates for some activity. And that's all we've got for you today. Huge thanks to Hot Girl Farmer for joining us and delivering the news. And we will talk to you some more tomorrow.
Today, we explore how Magnet Goblin, a cyber threat actor, exploits 1-day vulnerabilities for financial gain, targeting systems like Ivanti Connect Secure VPN and Magento. Learn about the widespread WordPress plugin vulnerability that left over 3,300 sites compromised with malware. Plus, unravel the complexities of Stored XSS, a persistent cyber threat lurking in databases and forums. Original Articles: For Magnet Goblin's exploits: https://research.checkpoint.com/2024/magnet-goblin-targets-publicly-facing-servers-using-1-day-vulnerabilities/ WordPress plugin vulnerabilities: https://www.bleepingcomputer.com/news/security/hackers-exploit-wordpress-plugin-flaw-to-infect-3-300-sites-with-malware/ Microsoft's chilly hack: https://www.theverge.com/2024/3/8/24094287/microsoft-hack-russian-security-attack-stolen-source-code Swiss government's ransomware dilemma: https://therecord.media/play-ransomware-leaked-government-files-swiss Duvel Moortgat Brewery's production pause: https://www.vrt.be/vrtnws/en/2024/03/06/cyber-attack-brings-production-at-duvel-moortgat-breweries-to-a/ FINTRAC's cyber incident: https://globalnews.ca/news/10335818/fintrac-cyber-incident/ Hamilton's ransomware attack: https://www.cbc.ca/news/canada/hamilton/ransomware-attack-1.7133457 Music: https://www.jeredjones.com/ Logo Design: https://www.zackgraber.com/ Tags: Magnet Goblin, WordPress Vulnerabilities, Popup Builder Plugin, CVE-2023-6000, Cybersecurity, HGF, 1-Day Vulnerabilities, Cross-Site Scripting, XSS, Malware Infections, Cyber Threat Actors, Web Security, Sucuri, Plugin Security, Website Hacking, Stored XSS, Cyber Attacks, Data Breach Search Phrases: Magnet Goblin cyber attacks WordPress Popup Builder plugin vulnerability Handling 1-Day vulnerabilities in cybersecurity Cross-Site Scripting attacks and prevention Latest malware infections in WordPress sites Cyber threat actors exploiting web vulnerabilities Sucuri reports on WordPress security How to secure websites against XSS vulnerabilities Understanding Stored XSS and its impacts Data breaches involving HGF this week Cybersecurity updates on WordPress plugins Protecting against Popup Builder CVE-2023-6000 Recent cyber attacks on web platforms Transcript: Mar 11 [00:00:00] transition: Welcome to The Daily Decrypt, the go to podcast for all things cyber security. Get ready to decrypt the complexities of cyber safety and stay informed. Stand at the frontier of cyber security news, where every insight is a key to unlocking the mysteries of the digital domain. Your voyage through the cyber news vortex starts now. [00:00:29] offsetkeyz: Welcome back to the daily decrypt. Today we're joined by hot girl farmer. Who's going to. Help recap the breaches from the last week. your favorite segment who's been popped. Then we're going to be talking about the magnet goblins gobbling up one day vulnerabilities. And finally. The word, press pop-up plugin vulnerability persists popping approximately 3,300 sites. [00:00:54] transition: Thanks for [00:01:00] watching! [00:01:00] hgf: first up on our list is a chili tail from the tech giant Microsoft on March 9th. Microsoft announced that Russian hackers, chilly from their previous solar winds attack, decided to warm up by spying on some emails of Microsoft, senior leaders. The hack evolved into a frosty situation with some of Microsoft secure source code stolen. Switching over to Switzerland where things got a bit too neutral for their liking on March 8th, the Swiss government found itself in a knot tighter than a Swiss wristwatch. A ransomware attack leaked 65,000 government documents. It appears the hackers played their cards, right with the play ransomware gang, proving that sometimes neutrality attracts more than just peace. You know, what if only they had some witches watching those Swiss wristwatches, which, which would, which, where, which Swiss watch. There were three witches. And there were three Swiss wristwatches, which witch would watch which Swiss wristwatch. Absolutely not. [00:02:00] Now pour one out for the Duvel Moortgat brewery on March 9th found its production as stale as the beer in a forgotten glass. The brewery known for its spirited, Duvel faced a ransomware attack that halted it's hops. It's a sobering reminder that no industry is immune and perhaps it's time for cyber attackers to barley there. Brew up some better hobbies, maybe. They be brewing up something. Yikes. March six, brought a cold front to Canada's fin track freezing some of it systems or the cyber incident as crisp as the Canadian winter, while their intelligence system stayed snug and warm. It's a stark reminder that even those guarding the treasure need to watch their own chest. Lastly Hamilton, a Canadian city got a taste of digital disruption, but services paralyzed faster than a moose caught in headlights. The ransomware attack confirmed on March 5th has shown that even city services can get frozen over in the cyber blizzard. It's a digital reminder that in the game of cybersecurity, sometimes you go hockey stick and sometimes you're [00:03:00] the puck. Mm. Canadians love hockey. Us too. That's what I hear anyways. [00:03:06] transition: Thanks for watching! [00:03:12] offsetkeyz: All right. So the magnet goblins are gobbling up one day. Vulnerabilities. This. Is coming to you from checkpoint research. Published on March 8th, check the show notes for the URL. But if financially motivated cyber threat actor called magnet goblin. Is getting really good at exploiting one day vulnerabilities. And one day vulnerabilities are essentially vulnerabilities that are announced. And discovered already. But not yet patched. So the one day signifies about how much time attackers have to exploit these vulnerabilities before they get patched. And the magnet goblets have gotten really good at exploiting one day vulnerabilities.. The magnet goblins have targeted such systems as Ivanti connect, secure VPN, Magento ClixSense and. [00:04:00] Potentially Apache active MQ. And they use these vulnerabilities to deploy a variety of malware, including the novel Linux version of nerdy and rat, which is a remote access Trojan and warp wire, a JavaScript credential stealer. Magnet goblins, rapid adoption of one day. Vulnerabilities really just emphasizes the problem we have with patching. And the need for it. There. Operations have historically centered around financial gain. As opposed to some other motivations, like. Political or social or hacktivism. They're all about the money. And they usually use techniques. Revolving around data theft to include ransomware. Really whatever they can use to get their money. There isn't much news here other than the fact that the magnet goblins. Are out there and we really. Are behind. On our practices of updating as well as on our updates. . So as soon as a one day vulnerability comes out, make sure to check. The specifics of [00:05:00] that vulnerability and look for the indicators of compromise surrounding it. [00:05:15] offsetkeyz: Alright, and to wrap up today's stories, We're going to be talking about that. WordPress pop-up plugin. Vulnerability that was announced last November. Recently seen an uptick. In exploits. It's impacting. The plugin version is 4.2 0.3 and older. And involves a cross site, scripting vulnerability. And really highlights the reluctance of WordPress users to update their plugins. So if you're a WordPress administrater or consumer of WordPress websites, which most of us are one of those two things. If not, both. The WordPress plugin must be active and also creating popups on your site. So for example, this plugin is enabled by default. When you. Launch a new WordPress website, which we don't [00:06:00] love. But the good news is that even though it's enabled by default, It must be creating pop-ups in order for it to be. Exploited. My fear when reading this was that, yes, this is a default plugin. And since it's a default plugin, there are what 300,000 WordPress sites out there, all with this plugin, just chilling, probably on updated. And unutilized but luckily it must be utilized as well as enabled. And that's because the attackers inject PHP code into one of the events. That triggers the pop-up. And that PHP code is then stored on the server, alongside the WordPress site, making it a stored cross site, scripting vulnerability. Which means that anyone who accesses the site and sees the pop-up. Is vulnerable. To that malicious PHP code. And that code can do many things. It can try to hijack your session cookie, which. Is the ultimate goal, because then the attacker is you [00:07:00] without actually having to log in. Or it could redirect you to fishing sites or really anything that they want. So if you're a WordPress admin, obviously update or disable. I'm going to lean towards disabled because pop-ups are really annoying. Especially since they're now vulnerable. Go ahead and use a banner. Go ahead and open up a new tab somewhere, but don't. Pop up right. As I'm about to click something on your website, I'm immediately going to navigate away from your website. If there's a, pop-up sorry for the rant. If you're a consumer. Try grabbing a pop-up blocker from Google Chrome app store. I think Google Chrome even comes with a built in app. For blocking pop-ups. And whether or not it blocks the specific pop-up on the site that you're visiting. It will at least alert you that there is a pop-up. And allow you to confirm or deny pop-ups on that site. So better than nothing. But yeah. Totally against pop-ups as a practice, I'm really glad my WordPress site doesn't have any popups for this reason. . And [00:08:00] also for the reason to not annoy the crap out of the few website, visitors that I get. If you'd like to visit a website with no popups, no advertisements. Go ahead and check out. Daily decrypt.news. Just the words, daily decrypt.news, and you will find words and pictures and sounds. But no ads. And no pop-ups. All right. That's all we've got for you today. Quick episode. Huge. Thanks to hot girl farmer for coming on and delivering the hot breaches in who's been popped. We will talk to you some more tomorrow. [00:09:00]
Mark Litton, President and CEO of Athira Pharma, discusses advancements in treating neurodegenerative diseases, highlighting the challenges in treating these diseases. Athira's approach uses the body's natural repair mechanism to enhance the repair and protection of nerve cells. Their lead molecule, fosgonimeton, enhances the hepatocyte growth factor (HGF) and crosses the blood-brain barrier to effectively target neurodegeneration. Mark explains, "At Athira, we're taking a completely novel approach where we're using the body's natural repair mechanism to help repair. We have spent many years designing molecules that enhance this mechanism. This is what we call the HGF/MET biology. This is a biology that has been known for over 30 years. It was originally discovered coming from the liver. What we know about it is that it's important in repairing, protecting, healing, and developing nerve cells." "What we found in a lot of neurodegenerative diseases is that this repair mechanism is impaired, or it slows down as we get older. One of the keys is you've got a molecule, and it's HGF, and then it binds its receptor, the MET receptor. When it binds that receptor, that's when the cell gets activated and starts repairing. There are numerous factors that happen along the way. There are two places one could enhance the receptor. We've decided to enhance the HGF, the protein itself, to help it bind to its receptor." #Athira #Alzheimers #Parkinsons #Dementia #ALS #AD #PD #NeurodegenerativeDiseases #Neurodegeneration #NeuronalHealth #Caregivers #PatientCommunity athira.com Download the transcript here
Mark Litton, President and CEO of Athira Pharma, discusses advancements in treating neurodegenerative diseases, highlighting the challenges in treating these diseases. Athira's approach uses the body's natural repair mechanism to enhance the repair and protection of nerve cells. Their lead molecule, fosgonimeton, enhances the hepatocyte growth factor (HGF) and crosses the blood-brain barrier to effectively target neurodegeneration. Mark explains, "At Athira, we're taking a completely novel approach where we're using the body's natural repair mechanism to help repair. We have spent many years designing molecules that enhance this mechanism. This is what we call the HGF/MET biology. This is a biology that has been known for over 30 years. It was originally discovered coming from the liver. What we know about it is that it's important in repairing, protecting, healing, and developing nerve cells." "What we found in a lot of neurodegenerative diseases is that this repair mechanism is impaired, or it slows down as we get older. One of the keys is you've got a molecule, and it's HGF, and then it binds its receptor, the MET receptor. When it binds that receptor, that's when the cell gets activated and starts repairing. There are numerous factors that happen along the way. There are two places one could enhance the receptor. We've decided to enhance the HGF, the protein itself, to help it bind to its receptor." #Athira #Alzheimers #Parkinsons #Dementia #ALS #AD #PD #NeurodegenerativeDiseases #Neurodegeneration #NeuronalHealth #Caregivers #PatientCommunity athira.com Listen to the podcast here
Intellectual Property is a vital part of the strategic tool-kit for business. Patent Attorney Marie Walsh from HGF explains why businesses must protect their IP and details why Ireland is lagging behind Europe in adopting the Unified Patent Court Luke Dully from Coosan established the clothing brand Walker and Hunt in 2019 and his range is already stocked in twenty-five stores and he has ambitious expansion plans. The opportunities and challenges of hybrid working explored with Workplace Leadership Architect Teresa Hand- Campbell. The mouth watering gastric event coming up in the midlands in September on Mount Briscoe Organic Farm.
Nessa live conversei com a médica neurologista Hellen Lacerda (@HellenLacerda.Neuro) Hellen é Médica formada pela UNIFOR. Neurologista com especialização em doenças cerebrovasculares pelo Hospital Geral de Fortaleza. Mestranda em ciência médicas - Unifor. Atua no HGF e em consultório e rede particular. Você também pode nos acompanhar no instagram, http://www.instagram.com/henriqueautran. E em nosso canal do YouTube: https://youtube.com/c/henriqueautran. Estamos também no telegram com um grupo exclusivo que você pode participar. Lá no telegram eu consigo compartilhar materiais exclusivos que não dá para compartilhar no Instagram. Além disso, toda quarta feira às 7:00 da manhã temos a Reunião da Rebelião Saudável com a participação de Profissionais de Saúde. Na reunião discutimos assuntos relevantes a respeito de saúde e qualidade de vida. Você pode acessar o grupo no telegram em https://t.me/RebeliaoSaudavel. Se você gosta de nosso trabalho, deixe um review 5 estrelas e faça um comentário no seu app de podcast. Essa atitude é muito importante para a Rebelião saudável e vai ajudar nosso movimento a chegar a cada vez mais pessoas.
Mariana Ferrão | Tom Almeida | Juliana Dantas | Bruno Oliveira | Luciana Dadalto | Maria Paula Bandeira | Silvana Aquino | Sabrina Ribeiro No dia 1º de junho de 2023, realizamos um encontro muito especial: uma homenagem à jornalista e escritora Ana Michelle Soares, que faleceu em janeiro, aos 40 anos, logo após finalizar o manuscrito de seu terceiro livro. AnaMi, como era chamada, tornou-se uma especialista em finitude e Cuidados Paliativos após descobrir um câncer de mama aos 28 anos de idade. E compartilhou a experiência e suas descobertas em palestras, livros, no perfil @paliativas (com 208 mil seguidores). Para celebrar esse legado e trazer ao público suas palavras, foi dada a largada ao “Instituto Ana Michelle Soares - A revolução paliativa”. Mariana Ferrão se formou em jornalismo pela PUC-SP. Trabalhou por 19 anos em TV, onde apresentou o Jornal da Band ao lado de Ricardo Boechat e Joelmir Beting. Especializou-se em saúde e participou da criação do programa Bem Estar da TV Globo, que apresentou durante quase uma década. É palestrante do TEDx, fundadora da welltech http://Soul.Me e criadora do Unboxing.Me, uma jornada de autoconhecimento que já transformou a vida de mais de 2 mil pessoas. Tom Almeida é fundador do movimento inFINITO, Diretor do “Death Over Dinner Brazil” e idealizador do Festival inFINITO, Cineclube da Morte, “A Morte no Jantar”, “Death over Drinks”, Podcast Conversas Sinceras sobre Viver e Morrer, colunista do Podcast FINITUDE e co-autor dos livros “Lutos por perdas não legitimadas na atualidade” e “Quando a morte chega em casa”, Ed Summus com curso de aprimoramento em Luto pelo Quatro Estações Instituto de Psicologia. Juliana Dantas é jornalista, locutora, apresentadora do podcast Finitude e diretora de comunicação do movimento inFINITO. Foi indicada ao Prêmio Comunique-se 2021 e é uma das 25 jornalistas do Prêmio Einstein +Admirados da Imprensa de Saúde, Ciência e Bem-estar, tanto em 2021 quanto em 2022. A jornalista assina o roteiro do documentário Esquina do Mundo. Passou pelas redações do Jornalismo da TV Gazeta, da Record News, da Rádio BandNews FM, foi editora e voz-padrão da Brasil Radio, de Orlando, e coordenou o Jornalismo da Alpha FM. Silvana Maria Aquino da Silva é Mestre em Sexologia pela UGF. Especialista em Psicologia Oncológica pelo Instituto Nacional de Câncer. Docente e Tutora do curso de Pós graduação em Cuidados Paliativos pelo Américas/IPEMED. Membro do Comitê de Psicologia, de Oncologia e de Pós Graduação da ANCP. Psicóloga com atuação em Oncologia e Cuidados Paliativos e GEP Cuidados Paliativos e População Negra da FIOCRUZ. Luciana Dadalto é Doutora em Ciências da Saúde pela faculdade de Medicina da UFMG. Mestre em Direito Privado pela PUCMinas. Consultora jurídica e advogada na Dadalto & Mascarenhas Sociedade de Advogados e administradora do portal http://www.testamentovital.com.br Bruno Oliveira é Doutorando em Filosofia (UERJ), Mestre em Ciência da Religião (UFJF), Licenciado em Filosofia (UCAM), Bacharel em Teologia (STBSB / BENNETT), Capelão titular do INCA HC4, Assistente espiritual do Placi, Professor Universitário. Sabrina Ribeiro é Médica especialista em Emergência e Terapia Intensiva com área de atuação em Cuidado Paliativo. Doutora em Ciências pela FMUSP. Professora de Cuidados Paliativos da plataforma Medmastery. Médica intensivista na unidade crítica de emergência do HCFMUSP e na unidade de terapia intensiva do HGF. Maria Paula Bandeira tem 36 anos é advogada, paciente com Câncer de Mama Metastático, idealizadora do @lencododia, membro da Casa Paliativa, entusiasta da vivência do momento presente. ➡ Conversa do Lançamento do Instituto Ana Michelle Soares - A revolução paliativa ▪ ▶ Aperte o play para ouvir!
Link to bioRxiv paper: http://biorxiv.org/cgi/content/short/2023.03.18.533289v1?rss=1 Authors: Deng, Y., Zhao, Z., Sheldon, M., Zhao, Y., Teng, H., Martinez, C., Zhang, J., Lin, C., Sun, Y., Yao, F., Zhu, H., Ma, L. Abstract: The molecular links between tissue repair and tumorigenesis remain elusive. Here, we report that loss of the liver tumor suppressor Lifr in mouse hepatocytes impairs the recruitment and activity of reparative neutrophils, resulting in the inhibition of liver regeneration after partial hepatectomy or toxic injuries. On the other hand, overexpression of LIFR promotes liver repair and regeneration after injury. Interestingly, LIFR deficiency or overexpression does not affect hepatocyte proliferation ex vivo or in vitro. In response to physical or chemical damage to the liver, LIFR from hepatocytes promotes the secretion of the neutrophil chemoattractant CXCL1 (which binds CXCR2 to recruit neutrophils) and cholesterol in a STAT3-dependent manner. Cholesterol, in turn, acts on the recruited neutrophils to secrete hepatocyte growth factor (HGF) to accelerate hepatocyte proliferation and regeneration. Altogether, our findings reveal a LIFR-STAT3-CXCL1-CXCR2 axis and a LIFR-STAT3-cholesterol-HGF axis that mediate hepatic damage-induced crosstalk between hepatocytes and neutrophils to repair and regenerate the liver. Copy rights belong to original authors. Visit the link for more info Podcast created by Paper Player, LLC
Link to bioRxiv paper: http://biorxiv.org/cgi/content/short/2023.02.24.529873v1?rss=1 Authors: Matchett, K. P., Wilson-Kanamori, J. W., Portman, J. R., Kapourani, A., Fercoq, F., May, S., Mackey, J. B., Brice, M., Zajdel, E., Beltran-Sierra, M., Sutherland, E. F., Wilson, G. C., Wallace, S. J., Kitto, L., Younger, N. T., Dobie, R., Oniscu, G. C., Wigmore, S. J., Ramachandran, P., Vallejos, C. A., Carragher, N., Simpson, K. J., Kendall, T. J., Rule, J. A., Lee, W. J., Hoare, M., Weston, C. J., Marioni, J. C., Teichmann, S., Bird, T. G., Carlin, L. M., Henderson, N. C. Abstract: The liver has a unique ability to regenerate however in the setting of acute liver failure (ALF) this regenerative capacity is often overwhelmed and emergency liver transplantation is the only curative option. To advance our understanding of human liver regeneration and to inform design of pro-regenerative therapies, we use paired single-nuclei RNA sequencing (snRNAseq)combined with spatial profiling of healthy and ALF explant human livers to generate the first single-cell, pan-lineage atlas of human liver regeneration. We uncover a novel ANXA2+ migratory hepatocyte subpopulation which emerges during human liver regeneration, and a corollary migratory hepatocyte subpopulation in a mouse model of acetaminophen (APAP)-induced liver regeneration. Importantly, interrogation of necrotic wound closure and hepatocyte proliferation across multiple timepoints following APAP-induced liver injury in mice demonstrates that wound closure precedes hepatocyte proliferation. 4-D intravital imaging of APAP-induced mouse liver injury identifies motile hepatocytes at the edge of the necrotic area, enabling collective migration of the hepatocyte sheet to effect wound closure. Depletion of hepatocyte ANXA2 expression reduces HGF-induced human and mouse hepatocyte migration in vitro, and abrogates necrotic wound closure following APAP-induced mouse liver injury. Taken together, our work dissects unanticipated aspects of liver regeneration, demonstrating an uncoupling of wound closure and hepatocyte proliferation and uncovering a novel migratory hepatocyte subpopulation which mediates wound closure following liver injury. Therapies designed to promote rapid reconstitution of normal hepatic microarchitecture and reparation of the gut-liver barrier may open up new areas of therapeutic discovery in regenerative medicine. Copy rights belong to original authors. Visit the link for more info Podcast created by Paper Player, LLC
Kanazawa University NanoLSI Podcast: Biological lasso: Enhanced drug delivery to the brainTranscript of this podcastHello and welcome to the NanoLSI podcast. Thank you for joining us today. In this episode we feature the latest research by Kunio Matsumoto and colleagues at the Kanazawa University NanoLSI. The research described in this podcast was published in the journal Nature Biomedical Engineering in November 2022 Kanazawa University NanoLSI website https://nanolsi.kanazawa-u.ac.jp/en/Biological lasso: Enhanced drug delivery to the brainIn a study recently published in the journal Nature Biomedical Engineering, researchers from Kanazawa University use a method called “lasso-grafting” to design therapeutics with enhanced longevity and brain penetration. Cell growth and repair are stimulated by biomolecules known as cytokines and growth factors. Unfortunately, delivering adequate concentrations of these molecules to the brain for treating neurological conditions like Alzheimer's disease is challenging as they are either cleared out of the blood very quickly or do not penetrate neural tissue effectively. A research team led by Kunio Matsumoto and Katsuya Sakai at Kanazawa University in collaboration with Junichi Takagi, Osaka University and Hiroaki Suga, the University of Tokyo has now used a technique called “lasso-grafting” to design molecules that replicate growth factors with longer retention in the body and brain penetration.The team synthesized a molecular entity comprising two components: macrocyclic peptides inserted into antibody fragments (known as Fc). Macrocyclic peptides are truncated proteins which can be engineered to resemble growth factors. Using lasso-grafting, a method previously developed by the researchers, the selected peptides were inserted into loops found on Fc. Now, lasso-grafting ensures that the macrocyclic peptides are easily exposed while keeping the structural integrity and function of both the peptide and Fc intact. Fc was used for this purpose as it remains in the body long enough and can easily add functionality of the Fab of choice.Using this process, a designer molecule replicating the hepatocyte growth factor (HGF) was first created. HGF binds a docking protein known as Met on the surface of cells to initiate signaling for cell growth and survival. Thus, aMD4 and aMD5, two macrocyclic peptides that can also bind to Met were first identified. They were then grafted into various sites on Fc until optimum insertion sites were found. When exposed to cells, Fc(aMD4) and Fc(aMD5) indeed latched onto Met receptors and initiated cellular signaling akin to HGF (Fig. 1b). Next, the longevity of Fc(aMD4) compared to Fc and HGF alone, was examined. When administered to mice, concentrations of HGF dwindled significantly after an hour while Fc(aMD4) persisted at levels enough to activate Met, for up to 200 hours. Markers for cellular replication were also active in these mice. Fc(aMD4) thus showed longevity and bioactivity. The final step was to determine the brain penetration of these designer molecules. For this purpose, aMD4 was inserted into an Fc of anti-transferrin receptor (TfR) antibody which accumulates in the mouse brain after peripheral administration (Fig. 1c). Indeed, TfR(aMD4) showed high accumulation and retention within the brain tissues of mice compared to Fc(aMD4) alone.This study depicts a novel strategy of inducing the effects of growth factors and cytokines with enhanced retention in brain tissues. What's more, based on the macrocyclic peptides and antibodies selected, this technique can be applied to imitate several growth factors. “Thus, lasso-grafting enables the design of protein therapeutics with thNanoLSI Podcast website
Mighty lioness hear me roar ! Celebrating the birth of a new beginning and the rebirth of the traveler, I love me a baddie but is it good for your health? Living in love and light why just admire it? Welcoming back to the stage Precious with HGF.
Nessa live conversei com o Dr. Neudson Alcântara (@Neudson_Neuro). Dr. Neudson é Neurologista, membro da Sociedade Brasileira de Cefaleias. Atua como Neurologista no Ambulatório de Cefaleias e Neuroemergência no Hospital Geral de Fortaleza, HGF, referência em Neurologia no Estado. Você também pode nos acompanhar no instagram, http://www.instagram.com/henriqueautran. E em nosso canal do YouTube: https://youtube.com/c/henriqueautran. Estamos também no telegram com um grupo exclusivo que você pode participar. Lá no telegram eu consigo compartilhar materiais exclusivos que não dá para compartilhar no Instagram. Além disso, toda quarta feira às 6:30 da manhã temos a Reunião da Rebelião Saudável com a participação de Profissionais de Saúde. Na reunião discutimos assuntos relevantes a respeito de saúde e qualidade de vida. Você pode acessar o grupo no telegram em https://t.me/RebeliaoSaudavel. Se você gosta de nosso trabalho, deixe um review 5 estrelas e faça um comentário no seu app de podcast. Essa atitude é muito importante para a Rebelião saudável e vai ajudar nosso movimento a chegar a cada vez mais pessoas.
Today is the day, Hot Girl Finance officially kicks off on September 19th! Hot Girl Finance is our 20 day audio program aimed at leveling up your life (from relationships, work, confidence, money, and more!). If you want to learn more or are are still on the fence on if it is the best fit for you, this week Chloe is sharing one of the Hot Girl Finances episodes on the podcast so you can get a feel for what HGF is all about.Ready to join the party? Sign up for Hot Girl Finance here: https://www.deeperthanmoney.com/hot-girl-finance
Richard tries out a BYO phone booth and Jo pauses on some tricky home maintenance. Richard is in awe of Jeremiah 31:20 and Jo makes a note in the margin of her book. Our 100th episode is coming up! Please send stories of how HGF has encourage you to homegrownfaith@hunterbiblechurch.orgJeremiah 31:20If Only, Jennie PollockSupport the show
Join Sean, Tom and very special guest Gemma Bastiani as they look at a BIG AFLW Grand Final and another edition of the HGF cup while asking the most important sporting question of all; How Good's Footy? Email us at howgoodsfooty@gmail.comYou can physically send us stuff to PO BOX 7127, Reservoir East, Victoria, 3073.Join our facebook group here or join our Discord here.Want to help support the show?Sanspants+ | Shop | TeesWant to get in contact with us?Twitter | Website | Facebook | RedditOr individually at;Sean | Tom | Duscher | Gemma See acast.com/privacy for privacy and opt-out information.
Welcome to Cannabis Daily - Your daily guide to cannabis news, industry trends, and trade ideas in under 5 mins.Elliot's Winners for the day:Tune Into our podcast episode to learn the 5 Cannabis Stocks Wall Street Predicts Will SkyrocketThe Biggest Cannabis Event of The Year Is Upon UsMy Winners for the dayAGFYHBORFHosted & Produced By:Elliot LaneAaron ThomasContact us at: cannabishour@benzinga.comFollow Benzinga Cannabis On Social MediaInstagramTwitterYouTubeLinkedInSubscribe to all Benzinga Podcasts at https://www.benzinga.com/podcastsSubscribe to the Cannabis Insider Newsletter to get more cannabis news and trending links delivered to your inbox.Tune in weekly to Cannabis Hour at 4 pm ET every Thursday for Cannabis News & Executive Interviews at bzcannabishour.comHit us up at https://www.benzinga.com/cannabis/ for more news today, tomorrow, and everyday.Access All The Cannabis Daily Episodes HereFor Top Gainers & Losers Cannabis stocks of the day check out https://www.benzinga.com/cannabis/stocksNOT FINANCIAL ADVICETo start the week, ladies and gentlemen, this is going to be a short week as good Friday does close the markets on Friday. So no need to talk about the public cannabis markets then. And next week Benzinga has cannabis capital conference, April 20th and 21st Benzing as psychedelic capital conference, April 19th will affect the schedule of this show, but we will have shows for you next week.So tune in, they'll just be a little bit of a different format. We're excited to finish April off with some unique content. What you all came for? Maryland's governor says he will not stand in the way of marijuana legalization. If voters approve it on the ballot, this November, the reform legislation would take effect without his signature.So he's not standing in the way, but not. Off pro-marijuana moment Harbor side and pylorus equity group Harbor site is H B O R F on the OTC Polaris equity group is private, but one of the leading lenders in the cannabis space, they complete a $77.3 million debt financing, an interest rate of 10.2, 5%, not the highest and not the lowest percentage rate I've heard.So overall I think decently fair and. The funding contained three separate loans and the final traunch was made available upon final closing of the three way merger that will transform Harbor side into the company. State houses is when with urban leaf and loud pack really expanding the footprint for Harbor side and pylorus equity group making that happen through a re real estate.HGF why on the NASDAQ announces their first total turnkey agreement with New Jersey based company, loud pack wellness, which is a cultivation and manufacturer operator aloud is one of eight Ortiz of both class one and class two manufacturer licenses. In the state through this total turnkey solution as we've been talking to Raymond Chang a few times about this, as he developed it in 2021 in early 20, 22, they will install 500 vertical farm units.They will use their fully integrated software platform. Aggregate insights. This will also include architectural and engineering services, operations consulting, and brand licensing. So AgriFood by really getting in there and becoming a full partner to the companies that utilize AgriFood services, green thumb industries, opening its 77th retail location.This is another rise dispensary on April 14th, GTB I F on the OTC. They are a tier one MSO have been forever. Hey, my soul being a multi-state operator. 77 locations is not as many as that, a Verano or curely for truly. So it's interesting to see how their revenue compares. And it seems that their retail locations have high value in comparison to a lot of the industry, something to continue to watch them as they open new dispensary's and get that, maybe six to 12 month run rate to get these revenues streams.Per stock news.com five cannabis stocks wall street predicts will skyrocket. These stocks are NASDAQ listed, G N L N. This is green lane and insulary house of brands provider. They are pretty massive when it comes to that Verano, V R N O F another multi-state operator, Cara therapeutics, C a R a Corbus pharmacy RBP, both biopharmaceutical company.In or completing their phase two trials and flora growth court, NASDAQ listed FLDC and international player. I think that one to me. Definitely a safe watch list are for sure. Flora growth Corp. One of the most aggressive international companies, both in the CBD and THC markets. And I think they're doing it very well in terms of being the first to export from Columbia, so on and so forth.So they have a large international scene with a footprint in the U S via. The federal trade commission. FTC is now treating consumer complaints regarding hemp and marijuana businesses. Similar to complaints against businesses in other industries increasing the amount of litigation against cannabis and hemp companies.They are looking for to septic or unfair advertising practices per Harris, brick and.com. Obviously, this is now. For this industry to grow for these products to be taken seriously, they must have in what they say they have in there. They must do what they say they do. And I would imagine this will increase the amount of companies that.Reprimanded and find, especially on the hemp side, not having what they say they have in their per see in S news, several Republican senators coming out against marijuana legalization. Senator Rick Scott does not support cannabis legalization saying he has family members that have drug problems. Senator Cruz says cannabis is illegal and harmful to you.And Senator Lankford, a Republican from Oklahoma says he absolutely does not use cannabis and claims. If you follow the science of cannabis, you will see. It is harmful. So a massive lack of education for all three of these guys. When it comes to cannabis per MJ, biz cannabis will add nearly $100 billion to the U S economy in 2022 for every $10 consumers spend at retail locations around $18 is injected back into the economy.Mostly local. Some of this is from taxes, but some is from transportation to these dispensaries and retail locations. Entertainment day-to-day needs from consumers. Finally last but not least that Kentucky governor, I always got to give a shout out to my Kentucky brethren. Andy Beshear may utilize an executive order to make medical cannabis accessible if he can.Of course, if the bill dies in the states house of representatives. So that would be a first unique and interesting move for the cannabis space. And. An executive order utilized for the cannabis space, but I think it would be met with massive popularity seeing as how marijuana, the state's gambling laws.They're all pretty in the dark ages there. This is a Kentucky in, I can safely say that. So with that being said, if I'm looking at winners today, I got to look at AGL. On the NASDAQ. I got to look at H B O R F on the OTC would be my two winners and also take a look at stock news dot comes, five cannabis stocks that wall street predicts will sky rocket.With that being said, thanks so much for tuning in you all. We will see you again tomorrow.Support this podcast at — https://redcircle.com/cannabis-daily/donationsAdvertising Inquiries: https://redcircle.com/brandsPrivacy & Opt-Out: https://redcircle.com/privacy
Welcome to Cannabis Daily - Your daily guide to cannabis news, industry trends and trade ideas in under 5 mins.Episode Summary:Mike Tyson in his 'Tyson 2.0' launch will bring 'Knockout OG' marijuana to Michigan dispensary.Urban gro UGR on the NASDAQ, announces another expansion to their stock repurchase program by another one and a half million.Stocks Mentioned In The Episode:DLTNFTCNNFERBBAVCNFElliot's Winners of The Day:Agrify(NASDAQ: AGFY)Flora Growth(NASDAQ: FLGC)Urban-gro(NASDAQ: UGRO)Curaleaf Holdings(OTCQX: CURLF)Hosted & Produced By:Elliot LaneAaron Thomas Contact us at: cannabishour@benzinga.comFollow Benzinga Cannabis On Social MediaInstagramTwitterYouTubeLinkedInSubscribe to all Benzinga Podcasts at https://www.benzinga.com/podcastsSubscribe to the Cannabis Insider Newsletter to get more cannabis news and trending links delivered to your inbox.Tune in weekly to Cannabis Hour at 4 pm ET every Thursday for Cannabis News & Executive Interviews at bzcannabishour.comHit us up at https://www.benzinga.com/cannabis/ for more news today, tomorrow, and everyday.Access All The Cannabis Daily Episodes HereFor Top Gainers & Losers Cannabis stocks of the day check out https://www.benzinga.com/cannabis/stocksNOT FINANCIAL ADVICEThe Information Contained on this Podcast is not intended as, and shall not be understood or construed as, financial adviceUnedited Transcript: My, my Mike what's up. It's good hump day. I hope I don't get fined or sued for that. This is Elliot lane, host of cannabis daily. Hope you guys are having a wonderful morning starting your day off, obviously with news and insights on the cannabis markets. Thanks as always to Aaron Thomas for producing the show.And Benzing for hosting. We want to bring you daily insights on what to look for in cannabis stocks and the industry as at large. So let's dive right in tons to look at today. AgriFood, they make news about once a week, so we should come to expect them here. A G F Y listed on the NASDAQ is set to acquire lab society.This is a company specializing in distillation and solvent separation solutions for Canada. Extraction. I did not understand those words either. But I do know there are very necessary parts of the processing part of cannabis oils and more, this further enhances Agrifoods position as a leader in extraction alongside their massive hydroponics arm, genetics.Basically is becoming an all around partner to cannabis operators and helping them grow their business at, in magnanimous levels. So props to Raymond Chang and team over there, edge HGF why continues to be. A very strong company to keep on your watch list. Mike Tyson in his Tyson, 2.0 launch will bring knockout O G marijuana flour to Michigan dispensary.So if you are in the Michigan market or you'd like to take little road trips to Michigan, make sure you keep an eye for knockout OJI on the shelves. That is Mike Tyson's flour, the safe banking bill. As we covered earlier this week, the text was added to a broader legislation bill for the house rules committee. It did get approved. So that's wonderful. This will be the sixth time safe has made it through some sort of house vote. It will now go to the house for to be voted on there. So props to representative ed Perlmutter, who is pushing this through as fast and as, as much as he can, before he goes out of this.Delta nine. This is DLT and F on the OTC announces a 32 million non-dilutive credit facility with connect first credit union connect. First in the news a lot lately with their loans to cannabis companies especially in Canada, obviously Delta nine will utilize capital to optimize its capital structure.So there we go. This includes a 23 mortgage $23 million mortgage. 5 million acquisition facility and the 4 million authorized overdraft. So a Delta nine seeking some lovely capital flow there. Next up we have Cura leaf. Can't forget about them. When they make news, we try to never do that. For who? All C U R L F on the OTC forms a partnership.Rep sleep. This is a retail execution software meant to help CPG teams with data-driven insights. CPG of course, being consumer packaged goods, which is the direction cannabis has been headed by many perspectives of the industry. But is a well-known brand or well-known company. They work with brands such as Kraft, Heinz Adidas, L'Oreal beyond meat, Mattel, and AB InBev. So really interesting and unique and powerful partnership from curely. They're truly TC NNF F celebrates a statewide rebrand in Maryland. This comes on the heels of rebranding, their Pence of Pennsylvania. Dispensary's. They're looking to get the truly name out there. Have a consumer and loyalty base. I believe they're referring to as true leavers. It makes sense to me, Columbia carry to the same thing in Florida as as we mentioned before, alongside this and. Many cannabis companies are doing similar things at the moment. Urban gro UGR on the NASDAQ, announces another expansion to their stock repurchase program by another one and a half million.This builds upon the already in place 7 million that was previously expanded earlier in January. So they are there. This of course is not a guarantee that they will repurchase the stocks, but it is an expansion. And if they do repurchase that as quite interesting, especially for shareholders of you grow a few earnings news here, we have American green.It says E R B on the OTC revenue is up 20% year over year in Q2 2022 to 515,000. They did release some. Of expecting it to grow another 55% in the next year, by the Q2 20. That, that ends next you do. So interesting young company there keep an eye on them. But they do have a pretty well-known cannabis brand that seems Africana, ABC and F announces Q4 2021 earnings, a record revenue of 1.3 million.What's interesting here, this. Fourth consecutive sequential increase of at least 3,000. So in four quarters, they keep growing by at least 30%, a super impressive 20 20, 20, 20 21 revenue is around 3.3 million up 133% year over year. And finally, last bit of news. We'll call out for the day flora growth Corp with some interesting news here, seeking approval from I N V I M a.This is basically the Colombian FDA they're seeking emergency use authorization under COVID 19 protocols. This will be for a cannabinoid based formula that they're researching with preventative applications to help with COVID-19. Super interesting. They're also seeking IP at the same time. So keep an eye on FLDC obviously probably not going to move it today.Maybe it will, but it that's the first, I believe for cannabis in Latin American market. So everybody, this is cannabis daily. Thanks so much for tuning in my winners for the day. Obviously you have to mention . I think curely probably gets a shout out in flora growth Corp and. So for winners today, keep an eye on him.We'll do this two more times this week rate and review us, let us know what you think. Hit BZ, cannabis.com to come meet me and Aaron Thomas in person in Miami. We really want to hear from you and meet you there until then. Y'all Hey investors. Thanks so much for tuning in to. Cannabis daily stock picks and news podcast everyday.Pre-market once again, this is not financial advice. Please do your own research. We hope we bring you the best and most efficient news for your investing. Continue to find us on benzinga.com/cannabis. Benzinga a.com/podcasts or on YouTube on Benzing has channel.Support this podcast at — https://redcircle.com/cannabis-daily/donationsAdvertising Inquiries: https://redcircle.com/brandsPrivacy & Opt-Out: https://redcircle.com/privacy
Welcome to Cannabis Daily - Your daily guide to cannabis news, industry trends and trade ideas in under 5 mins.Episode Summary:Say "I DO" at Planet 13 Hldgs(OTCQX:PLNHF) in their Las Vegas Superstore, also known as the world's largest dispensary. Elliot's Winners of The Day:High Tide(NASDAQ:HITI)Agrify (NASDAQ:AGFY)Zoned Props(OTCQB:ZDPY)Check out our April Cannabis Event in Miami. Hosted & Produced By:Elliot LaneAaron Thomas Contact us at: cannabishour@benzinga.comFollow Benzinga Cannabis On Social MediaInstagramTwitterYouTubeLinkedInSubscribe to all Benzinga Podcasts at https://www.benzinga.com/podcastsSubscribe to the Cannabis Insider Newsletter to get more cannabis news and trending links delivered to your inbox.Tune in weekly to Cannabis Hour at 4 pm ET every Thursday for Cannabis News & Executive Interviews at bzcannabishour.comHit us up at https://www.benzinga.com/cannabis/ for more news today, tomorrow, and everyday.Access All The Cannabis Daily Episodes HereFor Top Gainers & Losers Cannabis stocks of the day check out https://www.benzinga.com/cannabis/stocksNOT FINANCIAL ADVICEThe Information Contained on this Podcast is not intended as, and shall not be understood or construed as, financial adviceUnedited Transcript:Good morning investors, happy Wednesday. This is Elliot lane, host of cannabis daily. Thanks as always to our producer, Aaron Thomas, who makes everything happen as well as Benzinger for the platform. The show brings you a quick five to six minutes of cannabis investing news and or industry centric news, every single weekday.So let's dive right in, starting off. We have high tide, H I T I on the NASDAQ exchange. They opened two new can of cabana locations in Regina to begin selling adult use cannabis on January 27th. This brings their total brick and mortars to 109. So high tide continuing their aggressive expansion AgriFood.HGF why on the NASDAQ announces a $27.3 million. Private placement AgriFood will issue roundabouts 4 million, 20,994 shares of common stock at a combined purchase price of $6 and 80 cents per share. What's interesting to me about this is CEO along with other members of management and the board participated in the.However they did. So at $6 and 90 cents. So 10 cents more, I think this is a huge shot of confidence in from internally from Agra. I think it's aggressive. I think it's strong. I love this. So props to on this release next up, after having announced it would stop testing most employees for cannabis and backing a democratic led bill to legalize cannabis.Amazon is now backing Nancy mace, the freshmen Republican Congresswoman from South Carolina and her bill, the state's reform act. So I think this continues to be a boon for cannabis to have large tech and e-commerce plays. Join the fold, Mississippi lawmakers in the state, Senate and state house. Come to an agreed.And send their newly revised medical cannabis bill to governor Tate Reeves desk. The final passage of which is expected to today. I love this. I think it's fantastic to see more Southern states joined the fold. Mississippi would not have been my guest to be the first one of many. But th this is a boon, in my opinion, for sure that the amendment, I believe coverage, zoning restrict.For licensees planet 13, probably the most fun news of the day. That's PLN, H F on the OTC. Now allowing couples to say I do in their Las Vegas Superstore, also known as the world's largest dispensary. You can also. I exchanged vows at their cultivation facility, which is not super far from the Las Vegas strip.They are tiered packages, everybody. So if you're planning on doing this wedding, start at $400 for a quickie, you can also go at $600 and $800 and so on and so forth for further packages. So planet 13, continuing to innovate, continuing to look beyond the norms of the cannabis. And be a leader at drawing in tourism to their to their dispensary, to their brand.Truly TC in NF is rebranding all their Pennsylvania retail locations. This is somewhat to me, similar to what Columbia care did with their Florida dispensaries to camp. But they want to unite true leavers everywhere. And they're starting here with Pennsylvania or continuing here with Pennsylvania schwas or S H w Z on the OTC closes their acquisition of drift cannabis, which consists of two dispensary's and Boulder, Colorado.This brings their total number of stores in the states two 20. The cost of the acquisition was around three and a half million. Pretty evenly split between cash and common stock. This seems like a solid acquisition to me, perhaps, to Schwab as their next step. A decently interesting company that we don't talk about a whole lot.They really only put out news when they have news, which is a nice change of pace. But zone properties or Z D P Y on the OTC. And announced as their final completion of expansion at the Chino valley cultivation facility, this zone properties first and foremost is a leading real estate development firm in this space.And this will significantly increase the rental revenue with further opportunities to increase revenue down the line from this specific facility. So great news for zone properties, a great news for the future for CDP. Private multi-state operator elevate holistics over the course of 2021 donated $70,000 to treat veterans and Medicare members.So I love talking about stories like this. I love talking about giving back to the community and giving back to the medical cannabis community specifically that has fought so hard for cannabis legalization last but not least South Dakota law. Are looking to repeal part of their citizen backed bill for the specifically the home cultivation rights can imagine this is going to go over well. Home cultivation rights are a huge battleground in this industry. Anybody who is for cannabis, legalization, and wants to have some sort of support from the OJI community needs to be behind cultivation rights for individuals and home cultivation rights. This is not going to be popular. And those companies that are behind a bill such as this will not be popular.So just keep an eye on this. We'll see where this goes. And what's what comes of this for that community? Actually, I didn't lie. Hexo did provide an update that for their path forward plan saying they're ready, can products will increase in markets and expansion there. So Hexo NASDAQ listed.This is Elliot. With Benzinga host of your cannabis daily. Check us out. benzinga.com/cannabis all day. You'll get updates on the news throughout the day. There from Javier Hassein and his team of wonderful writers. Also check us out bzannabis.com. Come meet me in person. Come tell me you love me. Can tell you, Hey, come tell me you hate me.It doesn't matter, but we want to see you in Miami. You hear from industry leaders like Tilray sundial, Cura leaf, and more in April. Talk to you about. Hey investors. Thanks so much for tuning in to Benzing. As cannabis daily stock picks and news podcast every day. Pre-market once again, this is not financial advice.Please do your own research. We hope we bring you the best and most efficient news for your investing. Continue to find us on benzinga.com/cannabis, spending a.com/podcasts or on YouTube on Benzinga channel.Support this podcast at — https://redcircle.com/cannabis-daily/donationsAdvertising Inquiries: https://redcircle.com/brandsPrivacy & Opt-Out: https://redcircle.com/privacy
According to the Centers for Disease Control and Prevention (CDC), colorectal cancer is the second leading cause of cancer death in the United States. Researchers have observed elevated levels of the macrophage inflammatory protein CCL20 in colorectal cancer. Interactions between CCL20 and its receptor, CCR6, promote colorectal cancer through effects on neoplastic epithelial cells and modulation of the tumor microenvironment. However, the mechanism of these effects are not yet fully understood. “In particular, CCL20 acting on CCR6 expressed by colorectal cancer neoplastic epithelial cells induces proliferation, migration, and initiates an auto-feedback loop by inducing further secretion of CCL20. The mechanisms through which CCL20-CCR6 interactions elicit these effects is poorly understood.” Researchers—from the VA Boston Healthcare System, Harvard Medical School, Beth Israel Deaconess Medical Center, Dana-Farber Cancer Institute, and Brigham and Women's Hospital—conducted a study investigating the signaling pathways and mechanisms that underlie this colorectal cancer-promoting molecule. In 2021, the team authored a research paper, which was chosen as the cover paper of Oncotarget's Volume 12, Issue 24, and entitled, “CCL20 induces colorectal cancer neoplastic epithelial cell proliferation, migration, and further CCL20 production through autocrine HGF-c-Met and MSP-MSPR signaling pathways." Full blog - https://www.oncotarget.org/2021/11/24/new-study-investigation-of-colorectal-cancer-promoting-protein/ Sign up for free Altmetric alerts about this article - https://oncotarget.altmetric.com/details/email_updates?id=10.18632%2Foncotarget.28131 DOI - https://doi.org/10.18632/oncotarget.28131 Full text - https://www.oncotarget.com/article/28131/text/ Correspondence to - Jason S. Gold - jgold@bwh.harvard.edu Keywords - CCL20, CCR6, HGF, MSP, colorectal cancer About Oncotarget Oncotarget is a bi-weekly, peer-reviewed, open access biomedical journal covering research on all aspects of oncology. To learn more about Oncotarget, please visit https://www.oncotarget.com or connect with: SoundCloud - https://soundcloud.com/oncotarget Facebook - https://www.facebook.com/Oncotarget/ Twitter - https://twitter.com/oncotarget Instagram - https://www.instagram.com/oncotargetjrnl/ YouTube - https://www.youtube.com/c/OncotargetYouTube/ LinkedIn - https://www.linkedin.com/company/oncotarget Pinterest - https://www.pinterest.com/oncotarget/ Reddit - https://www.reddit.com/user/Oncotarget/ Oncotarget is published by Impact Journals, LLC please visit https://www.ImpactJournals.com or connect with @ImpactJrnls Media Contact MEDIA@IMPACTJOURNALS.COM 18009220957
Listen to short summaries of the latest oncology-focused research published in this week's issue of Oncotarget, Volume 12, Issue 24. https://www.oncotarget.com/archive/v12/i24/ Research Paper (Cover) - “CCL20 induces colorectal cancer neoplastic epithelial cell proliferation, migration, and further CCL20 production through autocrine HGF-c-Met and MSP-MSPR signaling pathways” https://doi.org/10.18632/oncotarget.28131 Research Paper - “The potential of PIVKA-II as a treatment response biomarker in hepatocellular carcinoma: a prospective United Kingdom cohort study” https://doi.org/10.18632/oncotarget.28136 Research Paper - “Caloric restriction causes a distinct reorganization of the lipidome in quiescent and non-quiescent cells of budding yeast” https://doi.org/10.18632/oncotarget.28133 Research Paper - “Optimization of tumor spheroid model in mesothelioma and lung cancers and anti-cancer drug testing in H2052/484 spheroids” https://doi.org/10.18632/oncotarget.28134 Research Paper - “Circulating low density neutrophils of breast cancer patients are associated with their worse prognosis due to the impairment of T cell responses” https://doi.org/10.18632/oncotarget.28135 Research Paper - “Regional and temporal heterogeneity of epithelial ovarian cancer tumor biopsies: implications for therapeutic strategies” https://doi.org/10.18632/oncotarget.10505 Editorial - “Undetected Barrett's esophagus: how do we improve early detection?” https://doi.org/10.18632/oncotarget.28005 (PDF Download) Research Perspective - “Hepatitis B x antigen (HBx) is an important therapeutic target in the pathogenesis of hepatocellular carcinoma” https://doi.org/10.18632/oncotarget.28077 Keywords - CCL20, colorectal cancer, hepatocellular carcinoma, biomarker, cellular aging, cellular quiescence, cancer patient, lung tumor, breast cancer, ovarian cancer, Barrett's esophagus, chronic liver disease, cancer, science, research, oncology About Oncotarget Oncotarget is a bi-weekly, peer-reviewed, open access biomedical journal covering research on all aspects of oncology. To learn more about Oncotarget, please visit https://www.oncotarget.com/ or connect with: SoundCloud - https://soundcloud.com/oncotarget Facebook - https://www.facebook.com/Oncotarget/ Twitter - https://twitter.com/oncotarget LinkedIn - https://www.linkedin.com/company/oncotarget Instagram - https://www.instagram.com/oncotargetjrnl/ YouTube - https://www.youtube.com/oncotargetyoutube Pinterest - https://www.pinterest.com/oncotarget/ Reddit - https://www.reddit.com/user/Oncotarget Oncotarget is published by Impact Journals, LLC. Please visit https://www.impactjournals.com/ or connect with @ImpactJrnls Media Contact MEDIA@IMPACTJOURNALS.COM 18009220957
Welcome to Cannabis Daily - Your daily guide to cannabis news, industry trends and trade ideas in under 5 mins.Episode Summary:Today On Cannabis Daily, host Elliot Lane goes over Earnings, which companies fell short and which excelled.Curaleaf Holdings (OTCQX:CURLF)Agrify (NASDAQ:AGFY)Goodness Growth Holdings (OTCQX:GDNSF)Aurora Cannabis (NASDAQ:ACB)MedMen Enterprises (OTCQX:MMNFF)Urban-gro (NASDAQ:UGRO)Village Farms Intl (NASDAQ:VFF)Cronos Group (NASDAQ:CRON)TerrAscend (OTCQX:TRSSF)Hosted & Produced By:Elliot LaneAaron Thomas Contact us at: cannabishour@benzinga.comFollow Benzinga Cannabis On Social MediaInstagramTwitterYouTubeLinkedInSubscribe to all Benzinga Podcasts at https://www.benzinga.com/podcastsSubscribe to the Cannabis Insider Newsletter to get more cannabis news and trending links delivered to your inbox.Tune in weekly to Cannabis Hour at 4 pm ET every Thursday for Cannabis News & Executive Interviews at bzcannabishour.comHit us up at https://www.benzinga.com/cannabis/ for more news today, tomorrow, and everyday.Access All The Cannabis Daily Episodes HereFor Top Gainers & Losers Cannabis stocks of the day check out https://www.benzinga.com/cannabis/stocksNOT FINANCIAL ADVICEThe Information Contained on this Podcast is not intended as, and shall not be understood or construed as, financial adviceUnedited Transcript:Good morning, investors. Hope you guys are having a wonderful week. Apologies for missing cannabis. Daily. Yesterday, we were hosting our seventh annual global FinTech awards. If you missed it, go back and see which brokerages, which trade techs, uh, took home the awards, but we're back to it today. And I'm going to go for a Guinness world book of records for the most earnings releases in the shortest amount of time.So that is my goal today. Uh, listen up. There are some big names that have come out so far. This. Uh, that I think are worth mentioning. So let's go ahead and dive right in with a couple other bits of news to follow as always thanks to Benzinger and Aaron Thomas for making this happen. Y'all all right.Earnings Cura leaf. We'll start big, go bigger, go home, right. And clearly see you RLF revenue. 30 317 million in Q3, 2021. That is up 2% sequentially quarter over quarter and 74% year over year. Not a whole lot of other news to really touch on. They opened a few dispensary's did make the acquisition of Trek that we covered before as well as Los Suenos farms.So, uh, those acquisitions are covered outside of that. A really big number. So clearly continuing to lead the space, uh, in that regard AgriFood, HGF why really considered recently to be the darling anciliary company of the space revenue up 460% year over year up three or up 33% quarter over quarter. It's a 15.8 million, uh, this past quarter with a backlog of business.That is now up to over 117 million, I think over 30 million of that was added just last quarter. And they're expecting to replicate that addition in this next quarter. So AgriFood is not slowing down. At all. Uh, I do not see this company. I'm going backward, at least within the next three months. Goodness growth, GD NSF, formerly Vireo health revenue increased 28% year over year, uh, excluding their divested assets in the quarter.So they did divest some assets, uh, or a subsidy. Uh, if you include those, um, assets, they really only increased 7%, uh, however, uh, or sorry. Yeah, 7% if you exclude those assets. So the numbers moving forward are a little bit less inflated. Then I think their press release would show. Um, but overall their numbers were apparently negatively affected by Arizona monsoon like weather.Uh, their total revenue was 13.8 million. So this is what I'm going to keep an eye on. I find this to be an overly negative press release, but normally you don't hear about the weather, uh, and in a press release. However, they are, uh, agricultural and outdoor in the, in the Arizona market. So, uh, we'll keep an eye on.You're Aurora cannabis. That's ACB Q1, a fiscal year 2022. There are medical cannabis revenue is at 23% year over year to 41 million. Their recreational cannabis revenue is down 44% year over year to 19.1 million last quarter. It was 19.5 million. So. Overall, we knew they were going to transition to a more medically dominant revenue driving company.Uh, especially in the international markets, Europe, they are expanding aggressively there in the Netherlands, uh, so on, so forth, but, uh, ACB. It's not, um, surprising that their overall revenue is somewhat down due to their recreational, uh, lack of recreational revenue. But I do want to see the medical cannabis side really take off, uh, otherwise, uh, you know, what's the point?So ACB another one that is always under the spotlight, uh, Madman we'll touch on them. Briefly. MMN F F Q1 fiscal year 2022 revenue increased 13.4% year over year to just under 40. And worth mentioning, uh, decreased margins due to more promotional activities. So they are getting out there a little bit more, uh, is what I take from that, which I like, I think they need to put their names back out there as one of the OGs in the space.Uh, they do have a net loss of over 55 million. So, uh, that number I'd like to see. Uh, next next quarter, of course you grow that's urban grow, UGR grow record Q3 revenue up 119% year over year to 18.3 million, uh, worth noting organic growth accounted for 106% of that. 119% growth. Uh, so no. 40 and a half million in cash on hand, and they raised their yearly guidance over 60 million.So it kill or earnings for urban growth. UGR on the NASDAQ Cronos group, uh, delays their filing due to impairment charge for us CBD operations. There are some rumors going around that they were about to get fully acquired by. Um, not the case, I would say, uh, we'll come back to them. I think more in the coming days, village farms, that's VFS on the NASDAQ, completed their acquisition of balanced health botanicals.This past quarter, their combined company, cannabis sales are over 31. Making about 43% of village farms, total company sales, pure sun farms is the top selling dried flower brand and Ontario, Alberta, and British Columbia. And that specific brands revenue increased 53% year over year, 13% quarter over quarter to 27.4 million us last one, holy moly, five and a half minutes.And that's a lot of earnings at five and a half minutes. Somebody sent me a. Um, we have, I ant this IDH U F revenue up 21% year over year down, 9% quarter over quarter. It's a 49.3 million. Their net loss is 15 million, which is actually 10 million less than their net loss was this time last year. So I liked seeing that.I think I, and this has been on the right path. Uh, the quarter over quarter is interesting to me, the decrease there. Uh, once again, I think I'd like to not see that trend. All right. Y'all come on. Todd ton of, uh, earnings, I think for me, AgriFood and urban growth, take the cake purely for main steady goodness growth, Aurora.Um, and uh, I ant this I'm keeping an eye on. Uh, there is a lot more earnings to come, but really quickly to touch on a few others tilt holdings, T L LTF expands their partnership with Aero brands to manufacture and distribute more inhalation products in Massachusetts terrorists in TRS RSSF looks to expedite the acquisition of gage cannabis.That's G AEG F with an amendment to their acquisition. Uh, they implore voters or shareholders to vote on that. Legislatively Seth Rogen and Sarah Silverman pushing senators for legalization. Uh, there was a bit of a click baity headline saying the Biden administration continued to deny public housing.If you do see that floating around, read the article, that's not really what it is. Um, can they, the federal law continues to be the. Um, deciding factor for public housing. Um, and right now the federal law is what it is. I think you can blame the Biden ministration, if you want for not acting quicker on legalizing cannabis.That is totally fair. Um, but when it comes to denying public housing, that's not something that's actively happening. That being said, um, obviously they need to change the stupid rule, uh, and, and let marijuana, uh, occur, especially in legal state markets. Oh, all right. Y'all Elliot lane, cannabis daily. I'm out of breath.I needed some water. Hope you enjoyed it. I will look forward to doing this the rest of the week. No more events this week. So you will hear from me on time. Moving forward. Talk to you tomorrow.Support this podcast at — https://redcircle.com/cannabis-daily/donationsAdvertising Inquiries: https://redcircle.com/brandsPrivacy & Opt-Out: https://redcircle.com/privacy
Welcome to Cannabis Daily - Your daily guide to cannabis news, industry trends and trade ideas in under 5 mins.Subscribe to all Benzinga Podcasts at https://www.benzinga.com/podcastsSubscribe to the Cannabis Insider Newsletter to get more cannabis news and trending links delivered to your inbox. Tune in daily to Cannabis Hour at 4:30 p.m. ET for Cannabis News at bzcannabishour.com.Hit us up at https://www.benzinga.com/cannabis/ for more news today, tomorrow, and everyday.Episode Summary:High Tide Confirms Inclusion In Fourth Cannabis ETF Since Its NASDAQ DebutJushi Holdings price target was downgraded to $4 from $4 .80. The Aurora Cannabis price targets is upgraded to $9.50 Canadian Dollars from $8.30 due to increased export projections, Analysts expecting roughly 9 million in exports to Israel in the December quarter, and also expects Aurora to be a key player in Germany, Poland, and France.Heritage Cannabis Holding (OTCQX:HERTF)Akerna(NASDAQ:KERNJushi Holdings(OTCQX:JUSHF)Aurora Cannabis(NASDAQ:ACB)GrowGeneration(NASDAQ:GRWG)HEXO(NASDAQ:HEXO)High Tide(NASDAQ:HITI)Flora Growth(NASDAQ:FLGC)Agrify (NASDAQ:AGFY)BENZINGA CANNABIS CAPITAL CONFERENCEThe premier gathering of cannabis entrepreneurs and investors in North America returns for a 2-Day Hybrid Event on October 14-15.Hosted & Produced By: Elliot LaneAaron Thomas Contact us at: cannabishour@benzinga.comFollow Benzinga Cannabis On Social MediaInstagramTwitterYouTubeLinkedInAccess All The Cannabis Daily Episodes HereAlso Join us at the Benzinga Cannabis Hour Podcast, weekly on Thursdays at 4 PM EST.For Top Gainers & Losers Cannabis stocks of the day check out https://www.benzinga.com/cannabis/stocksNOT FINANCIAL ADVICEThe Information Contained on this Podcast is not intended as, and shall not be understood or construed as, financial adviceUnedited Transcript:Friends. It is Wednesday. It is another hump day here. Welcome to cannabis daily. This is Elliot lane from Ben Zynga as always thanks to Aaron Thomas and our friends for helping. Happen. We've got a lot to cover today from earlier this week, as well as news that is coming overnight. So let's jump into the cannabis space here a little earlier this week, shots a heritage, Candace.I did not mention this, but H R T F is now supplying Australian companies with medical cannabis products. They have truly, uh, just dove in the past few months, uh, and through expansion and getting their name out there, uh, working in new partnerships, expanding. I'm really liking what I'm seeing out of her.Uh, Corona a couple news items this week. Uh, they are K E R N on the NASDAQ, their current investors reinvested $20 million via convertible debt financing into the company. Uh, and, and they completed the acquisition of 365 cannabis, which I believe was about 17 million. Uh, so two. Really nice bits of news for Corona there this week.Uh, I'd love to see their stock trend up a little bit because I think they've earned it to be quite honest with you guys. I think Jessica does a pretty fantastic job over there. Uh, interesting bit of news that isn't necessarily directly related to a stock. The former med men. Exactly. Uh, filed a suit against their new work company.I should say coastal holdings, there are no longer directly associated, but they say they have a right to approve the sale or. To the parent company, they filed a lawsuit with their company or former company, coastal holdings. I gotta tell you, these guys are just not really ever in the news for the right reasons.Uh, interesting bit of news there though. Cantor Fitzgerald releases two reports. Jewishy price target was downgraded to $4 from $4 and 80 cents. Uh, however Pablo remained neutral on them. The Aurora price targets. Upgraded that's NASDAQ listed ACB to $9 and 50 cents Canadian from $8 and 30 cents Canadian due to increased export projections, Pablo expecting roughly 9 million in exports to Israel in the December quarter, and also expects Aurora to be a key player in Germany, Poland, and France, honestly, y'all this is the first bit of good news for ACB.I have. In some time. Uh, so, you know, Pablo. Not necessarily giving up hope, uh, on their numbers, on their projections. Uh, I think, I think this is interesting for more shareholders and hopefully can, can battle some of that dilution we've seen recently urban grow their stock is Eugene borrow on the national.Uh, is up their stock is up on the announcement of the launch of its financial services division. The end game here being to provide its clients cap ex leasing solutions. And this is happening with a partnership with X S financial fire and flower. That is F F L w F on the OTC advances, their partnership with circle caves, parent company to open new fire and flower.Dispensary's adjacent. To existing circle K stores in Canada. The first of these will be an Alberta, Saskatchewan, and Manitoba. This is I think, a massive potential here for fire and flower, a circle K obviously being a pretty regular store in the states as well. So, uh, the idea here being to extend this into the U S and when the opportunity arises.Probably after federal legalization plays out a nice little article on benzinga.com/cannabis yesterday, grow generation that's G RWG once, uh, this year, and maybe still considered by some, to be the cannabis. Has a better five-year return then get this game. Stop AMC and Blackberry. So GRW G better five-year return the game, stop and Blackberry head to benzinga.com/cannabis for that full article in diva, that's in D V a F borrows, an additional eight and a half million from sundial, S N D L sun stream.Bancorp, as I've said before I applaud sundial and what they've done, uh investment-wise and putting their. Uh, in back into the space, uh, and helping and really taking advantage of that mean stock status, uh, to grow different aspects of their business. I love this partnership. Uh, am I, once again, applaud it.Hexo hex partnership with Molson. Uh, for their very Vel CBD beverage is now expanding to 17 states. Uh, once again, Hexo, you know, we've seen some cool news sustainability wise, uh, but not really, um, visible for all the right reasons this year, since, uh, especially since their acquisition. Um, I believe it was, um, um, xenopus it was their acquisition of cannabis, but, uh, this is a great bit of news for them.A couple more here. Y'all high tide hit. I listed on the NASDAQ has been added to the bud X ETF on the nicey for growth forms for a pharma and launches global clinical trials utilizing. Uh, artificial intelligence and machine learning to help develop drugs from the cannabis plant that interact with certain gene targets responsible for specific diseases and conditions, just incredibly broad.Nobody knows what that means other than they are enacting a biotech arm. Uh, but I'm all for R and D whenever we can get it. So let's see how this, um, this grows and evolves there. Uh, last bit of news stock wise that I'll announce today. buys cannabis and hemp extract. Uh, equipment companies for 50 million that is cascade and precision extraction solutions, both in incredible companies.And precision is a powerhouse. They've, they've been a private powerhouse for a long time, and , in my opinion is making an incredible acquisition here. Uh, again, that's NASDAQ listed. HGF why, so y'all a ton of news today, uh, covering some from earlier this week, but a lot from, uh, over in the night as well.Uh, once again, this is Elliot lane with cannabis daily. Thanks again to Erin Thomas y'all check out B Z cannabis.com. That's BZ cannabis.com. Our event is next Thursday and Friday. You can attend virtually or in New York city, incredible lineup of speakers, and we hope to see you there. Thanks so much. You all see.Support this podcast at — https://redcircle.com/cannabis-daily/donationsAdvertising Inquiries: https://redcircle.com/brandsPrivacy & Opt-Out: https://redcircle.com/privacy
Combining his medical expertise with his business acumen, Angion's CEO, Dr. Jay Venkatesan, is focused on meaningfully improving both health outcomes for patients in need and economic outcomes for the healthcare system. After successes at McKinsey, Bain, Ayer Capital, and Alpine BioVentures, Dr. Venkatesan is now seizing on what he describes as a rare opportunity to lead Angion, whose products have the potential to transform care for millions of patients. He was originally attracted to Angion – a 20-year old biotech company – as an investor due to its HGF mimetic technology being developed to treat acute organ injuries, including acute kidney injury. Dr. Venkatesan then joined Angion as its CEO after realizing the true potential of Angion's science and its rich research and clinical development pipeline. I spoke with Dr. Venkatesan recently, ahead of two key Q4 data readouts from Angion's lead HGF mimetic program.
On this Artist Spotlight episode we welcome the Co-Founding Directors of the Higher Ground Festival, Temple Kemezis & Pablo Francisco Ruvalcaba. The Higher Ground Festival brings Northern Manhattan artists together to network and create interdisciplinary, stage-based collaborations produced by the festival and present them locally during the annual HG Premiere Performance. Since their inaugural year in 2015, Higher Ground has brought over 150 artists together through their programming and have produced 27 Premiere Collaborations presented free to the Uptown Community. Additionally, they have presented over 10 new works and works-in-progress outside the HGF season. Tune in to hear what Higher Ground brings Uptown NYC and then check out their work at www.creatinghigherground.com
The Chinese will be celebrating the hungry ghost festival very soon. Let us explore Hungry Ghost Festival.Traditionally HGF falls on the 15th day of the seventh month of the lunar calendar. During this period, many Chinese worship their ancestors and make offerings to wandering souls that roam the earth. There is a slight difference in ideology of the way Taoist and Buddhist followers observe HGF. Taoists focus on appeasing the wandering souls released from the netherworld, while the emphasis of the Buddhists is filial piety. Join Wraith in this paranormal mystery journey where you will think and find whether which are fact and which are fiction....If you have any stories of your own and want Wraith to share to all our listeners,Do email at latenightmysteries@gmail.comSUBSCRIBE US ON YOUTUBEhttps://www.youtube.com/channel/UCYeg3nLF4mexguxo7RMPkOwLIKE OUR FACEBOOK PAGE: https://www.facebook.com/LateNightMysteriesSupport the show (https://www.patreon.com/LateNightMysteries)
Research suggests quercetin can alleviate pulmonary arterial hypertension by regulating inflammatory cytokines Zhejiang Provincial People’ s Hospital (China), April 9, 2021 According to news reporting originating in Zhejiang, People’s Republic of China, research stated, “This study aimed to investigate the effects of quercetin in the treatment of pulmonary arterial hypertension (PAH) in a murine model. Thirty-six adult male rats were randomly divided into three groups: the control group (saline), monocrotaline (MCT) - induced PAH group (MCT group) and quercetin treatment group (prevention group).” The news reporters obtained a quote from the research from Zhejiang Provincial People’ s Hospital, “After modelling, the animals from prevention group received 100 mg/(kg bw/day quercetin by gavage and the gavage for 20 days, while the animals from the other two groups received the same amount of 0.9% sodium chloride saline solution. The mean pulmonary artery pressure, right ventricular index and relative expression levels of HIF-1 (hypoxia-inducible factor 1), ET-1(vascular endothelin-1), TGF-beta 1 (transforming growth factor-beta 1), VEGF (vascular endothelial growth factor), IL-1 (interleukin-1), IL-6 (interleukin-6) and TNF-alpha (tumour necrosis factor alpha) in lung tissues significantly increased in MCT group compared with the control group, 21 days after modelling. The levels of HGF (hepatocyte growth factor) and NAC (N-acetyl-L-cysteine) significantly increased compared with the control group. The treatment with quercetin significantly decreased the level of mean PAH, right ventricular index and relative expression levels of H1F-1, ET-1, TGF-beta 1, VEGF, IL-1, IL-6 and TNF-alpha in lung tissues compared with MCT group and significantly decreased the levels of HGF and NAC. In vitro experiment with PCEC (pulmonary capillary endothelial cells) from the three groups showed that in the MCT group the cell proliferation was significantly decreased and the apoptosis was significantly increased compared with the control group, while the quercetin treatment inhibited the MCT-induced cell apoptosis and promoted cell proliferation.” According to the news reporters, the research concluded: “Quercetin can alleviate PAH by regulating the inflammatory cytokines, promoting cell proliferation and inhibition of cell apoptosis.” This research has been peer-reviewed. Intermittent fasting shown to provide broad range of health benefits in new study Texas State University, April 7, 2021 Intermittent fasting may provide significant health benefits, including improved cardiometabolic health, improved blood chemistry and reduced risk for diabetes, new research conducted in part at Texas State University indicates. Matthew McAllister, assistant professor in the Department of Health and Human Performance, co-authored the study with Liliana Renteria, graduate research assistant in the Department of Health and Human Performance, along with Brandon Pigg and Hunter Waldman of the Department of Kinesiology at Mississippi State University. Their research, "Time-restricted feeding improves markers of Cardiometabolic health in physically active college-age men: A 4-week randomized pre-post pilot study," is published in the journal Nutrition Research (https://doi.org/10.1016/j.nutres.2019.12.001). "What we are doing is time-restricted feeding. It is a way to use fasting each day to promote various aspects of cardiometabolic health," McAllister said. Time-restricted feeding (TRF) has been shown to improve body composition and blood lipids, as well as reduce markers of inflammation and oxidative stress. However, those results originated from rodent models and studies with small human samples. In the Texas State study, 22 men were divided into two groups to complete a 28-day study. Subjects ate daily during one eight-hour period, for example, between 9 a.m. and 5 p.m. or between noon and 8 p.m. For 16 hours of the day, they did not eat or drink anything other than water. While both groups underwent TRF, one group's caloric intake was controlled during meal periods to ensure they ate the same amount as before the study, while members of the other group were allowed to eat as much as they wanted. "My initial thought was that if you are going to restrict the time, you would eat fewer calories. And the reduction of daily calories would cause weight loss and other health benefits," McAllister said. "But these benefits are found with no change in caloric intake—things like loss in body fat, reduced blood pressure, reduced inflammation.” Fasting blood samples were analyzed for glucose and lipids, as well as adiponectin, human growth hormone, insulin, cortisol, c-reactive protein, superoxide dismutase, total nitrate/nitrite and glutathione. Results showed that both groups experienced significant reductions in body fat, blood pressure and significant increases in adiponectin and HDL-c. No change in caloric intake was detected among members of either group. The COVID-19 pandemic has been linked with six unhealthy eating behaviors University of Minnesota Medical School, April 12, 2021 A new probe into the lingering impacts of the COVID-19 pandemic revealed correlations to six unhealthy eating behaviors, according to a study by the University of Minnesota Medical School and School of Public Health. Researchers say the most concerning finding indicates a slight increase or the re-emergence of eating disorders, which kill roughly 10,200 people every year -- about one person every 52 minutes. U of M Medical School's Melissa Simone, PhD, a postdoctoral research fellow in the Department of Psychiatry and Behavioral Sciences, collaborated with School of Public Health professor and head of the Division of Epidemiology and Community Health, Dianne Neumark-Sztainer, PhD, MPH, to learn from study participants in Neumark-Sztainer's Project EATbetween April and May 2020. "The COVID-19 pandemic has resulted in the rapid implementation of public health policies to reduce transmission of the virus. While these protections are necessary, the disruptions to daily life associated with the ongoing pandemic may have significant negative consequences for the risk of eating disorders and symptoms," said Simone, who is the lead author of the study. "Eating disorders have one of the highest mortality rates across all psychiatric health concerns, and therefore, it is important to try to make links between the consequences of the pandemic and disordered eating behaviors. The study aimed to understand potential associations between stress, psychological distress, financial difficulties and changes in eating behaviors during the COVID-19 pandemic through the analysis of both qualitative and quantitative data. Simone's findings, published in theInternational Journal of Eating Disorders, found six key themes of eating behavior changes: Mindless eating and snacking; Increased food consumption; Generalized decrease in appetite or dietary intake; Eating to cope; Pandemic-related reductions in dietary intake; And, a re-emergence or marked increase in eating disorder symptoms. Approximately 8% of those studied reported extreme unhealthy weight control behaviors, 53% had less extreme unhealthy weight control behaviors and 14% reported binge eating. The study revealed that these outcomes were significantly associated with poorer stress management, greater depressive symptoms and moderate or extreme financial difficulties. "There has been a lot of focus on obesity and its connection with COVID-19. It is also important to focus on the large number of people who have been engaging in disordered eating and are at risk for eating disorders during and following the pandemic," said Neumark-Sztainer, who is the principal investigator of Project EAT. "The majority of the young adults in our study are from diverse ethnic/racial and lower income backgrounds, who often do not receive the services they need. To ensure health inequities do not increase, we need to meet the needs of these populations." Simone added, "The economic consequences of the COVID-19 pandemic will likely persist long beyond the dissemination of a vaccine. Because our findings suggest that moderate or severe financial difficulties may be linked with disordered eating behaviors, it is essential that eating disorder preventive interventions and treatment efforts be affordable, easily accessible and widely disseminated to those at heightened risk. As such, online or mobile-based interventions may prove to be effective and accessible modes for targeted intervention efforts." This study was funded by the National Heart, Lung, and Blood Institute (R01HL116892, R35HL139853: Principal Investigator: D. Neumark-Sztainer), the National Center for Advancing Translational Sciences (TL1R002493, UL1TR002494), and the National Institute of Mental Health (T32MH082761). Ginseng and anti-obesity: Does Asian variety offer greater weight loss hope? Tennessee State University, April 5, 2021 Studies comparing the differing anti-obesity effects of Asian and American ginseng are urgently needed, it has been claimed, not least because they are thought to have opposite medical effects in Traditional Chinese Medicine (TCM). Writing in a review in the Journal of Nutritional Biochemistry, scientists from Tennessee State University said a number of investigations had been conducted on ginseng in preventing and treating of obesity. However, the effect and the relevant mechanisms behind how ginseng works as an anti-obesity treatment are still controversial, they added, and the issue is clouded by the differing uses of American and Asian ginseng in TCM. The former is used to treat yin manifestations of Qi (life energy), while the latter tackle yang manifestations. Therefore, Asian ginseng has often been used to help treat, fatigue, poor appetite, diarrhoea, breath shortness, feeble pulse, spontaneous perspiration, febrile diseases, amnesia, insomnia and impotence. On the other hand, American ginseng is used to treat diseases such as cough, blood sputum, dysphoria, fatigue and thirst. “Although the potential anti-obesity effect of Asian ginseng has been investigated in mice and humans in Asia in the last several decades, the anti-obesity effect and mechanism of ginseng are still not fully understood, especially in humans,” wrote the researchers. “Moreover, high-quality studies of the effects of ginseng in the United States are rare, particularly whether and how American ginseng prevents obesity is almost blank.” They said this was area ripe for further investigation, and pointed to their own unpublished data which showed that while Asian ginseng significantly inhibited fat accumulation in 3T3-L1 cells, American ginseng has no such effect at the same concentration (1 mg/ml). They suggest this could be due increased fat accumulation caused by one of the major ginsenosides in American ginseng that is not detectable in Asian ginseng “The different anti-obesity effect between American ginseng and Asian ginseng may also result from the different profiles of other ginsenosides,” they added. “There is only one study showing that Asian ginseng extract intake exerted a weight loss effect in obese women,” they wrote. “American ginseng extract or whole plant/berry has not been investigated for anti-obesity in humans. In addition, there is no report using human primary cells investigating the antiobesity effect of ginseng and ginsenosides.” They argue that standardised ginseng production is sorely needed to overcome the fact that the results of existing studies “are controversial”. “These controversial results at least partly come from the variety of the quality of ginseng, especially the whole extract and juice. The quantity and composition of ginsenosides in ginseng plants are dramatically influenced by species, age, and part of the plant, cultivation methods, harvesting season, preservation methods and geographical distribution,” they state. “However, almost all ginsenosides or extracts in these studies were prepared in the individual labs or from different companies, it is almost impossible to keep the quality at the same level, particularly the whole extract.” The authors concluded; “Although Asian and American ginsengs have similar profiles of active ingredients, the different percentage of crude saponins (4.8%–5.2% in Asian ginseng vs. 7.0%–7.3% in American ginseng) and the specific ginsenoside (Rf only in Asian ginseng, F11 only in American ginseng) may contribute to the different functions of these two ginsengs.” “Therefore, it is very important to compare the medical effects using modern scientific approaches.” Study links prenatal phthalate exposure to altered information processing in infants University of Illinois, April 6, 2021 Exposure to phthalates, a class of chemicals widely used in packaging and consumer products, is known to interfere with normal hormone function and development in human and animal studies. Now researchers have found evidence linking pregnant women's exposure to phthalates to altered cognitive outcomes in their infants. Most of the findings involved slower information processing among infants with higher phthalate exposure levels, with males more likely to be affected depending on the chemical involved and the order of information presented to the infants. Reported in the journal Neurotoxicology, the study is part of the Illinois Kids Development Study, which tracks the effects of hormone-disrupting chemicals on children's physical and behavioral development from birth to middle childhood. Now in its seventh year, IKIDS has enrolled hundreds of participants and is tracking chemical exposures in pregnant women and developmental outcomes in their children. Susan Schantz, a neurotoxicologist and professor emerita of comparative biosciences at the University of Illinois Urbana-Champaign, is the principal investigator of the study. She is a faculty member in the Beckman Institute for Advanced Science and Technology, which houses the IKIDS program at Illinois. "IKIDS is part of a larger initiative funded by the National Institutes of Health, the Environmental Influences on Child Health Outcomes program. It is tracking the impact of prenatal chemical exposures and maternal psychosocial stress on children's growth and development over time," Schantz said. "We measure numerous birth outcomes, including birth weight and gestational age. We also assess infants' cognition by studying their looking behavior. This allows us to get measures of working memory, attention and information-processing speed." The researchers analyzed metabolites of three commonly occurring phthalates in urine samples regularly collected from the pregnant women in the study. The chemical exposure data were used in combination with assessments of the women's infants when the children were 7.5 months old. The researchers used a well-established method that gives insight into the reasoning of children too young to express themselves verbally: Infants typically look longer at unfamiliar or unexpected images or events. The team used an infrared eye-tracker to follow each infant's gaze during several laboratory trials. With the infant sitting on a caregiver's lap, researchers first familiarized the child with two identical images of a face. After the infant learned to recognize the face, the researchers showed that same face paired with an unfamiliar one. "In repeated trials, half of the 244 infants tested saw one set of faces as familiar, and half learned to recognize a different set of faces as familiar," Schantz said. "By analyzing the time spent looking at the faces, we could determine both the speed with which the infants processed new information and assess their ability to pay attention." The assessment linked pregnant women's exposure to most of the phthalates that were assessed with slower information processing in their infants, but the outcome depended on the specific chemical, the sex of the infant and which set of faces the infant viewed as familiar. Male infants, in particular, tended to process information more slowly if their mothers had been exposed to higher concentrations of phthalates known to interfere with androgenic hormones. The specific characteristics of faces presented to the infants in the familiarization trials also appeared to play a role in the outcome, the researchers reported. Phthalate-exposed children who were first familiarized with faces from Set 2 were more likely to experience slower processing speed than those familiarized with faces from Set 1. The finding is perplexing, Schantz said, but is likely related to differences in the infants' preferences for the faces in the two sets. It also may be an indication that familiarization with the Set 2 faces is a more sensitive detector of changes in processing speed related to phthalate exposure. "Most previous studies of the relationship between prenatal exposure to phthalates and cognition have focused on early and middle childhood," Schantz said. "This new work suggests that some of these associations can be detected much earlier in a child's life." Heart failure and stroke rising in men under 40 University of Gothenburg (Germany), April 8, 2021 Heart failure and stroke are unusual diagnoses among younger people. But they are now clearly on the rise in men below the age of 40, according to a University of Gothenburg study. The scientists have found links to obesity and low fitness in the upper teens. The present study, published in Journal of Internal Medicine, includes data on 1,258,432 men who, at an average age of 18.3 years, enlisted for military service in Sweden between 1971 and 1995. Particulars of the men's weight, height and physical fitness on enlistment were merged with data in the National Board of Health and Welfare's National Patient Register and Cause of Death Register for the period 1991-2016. From when they enlisted, the men were thus monitored over a period exceeding 20 years. The proportion of participants who were overweight at the time of enlistment, i.e. with a body mass index (BMI) of 25-30, increased from 6.6 to 11.2 percent between 1971 and 1995, while the proportion with obesity (BMI over 30) rose from 1.0 to 2.6 percent. During the same period, their fitness level at the time of enlistment also declined slightly. "These factors -- that is, overweight, obesity and low fitness -- partly explain the large increase in heart failure we see in the study, and the rise in stroke as well," states David Åberg. An Associate Professor at Sahlgrenska Academy, University of Gothenburg, and specialist doctor at Sahlgrenska University Hospital, Åberg is the study's first author. "It's pleasing to see, despite rising obesity, a fairly sharp fall in heart attacks among these younger men, and also their reduced mortality from cardiovascular diseases," he continues. Heart-failure cases within 21 years of enlistment rose, according to the study, by 69 percent -- from 0.49 per 1,000 of the men who had enlisted in the first five years (1971-75) to 0.83/1,000 of those who enlisted in the last five (1991-95). The number of stroke cases -- cerebral infarction and cerebral hemorrhage -- showed a similar trend. The increase for cerebral infarction was 32 percent, from 0.68 for the first five-year cohort to 0.9 per 1,000 for the last. For cerebral hemorrhage the rise was 20 percent, from 0.45 to 0.54 per 1,000. In contrast, heart attacks within 21 years of enlistment fell by 43 percent, from 1.4 to 0.8 per 1,000, of the cohorts enlisting first and last respectively. The proportion of deaths from all cardiovascular disease also decreased, by 50 percent -- from 1.5 to 0.74 per 1,000. The fact that the trends for cardiovascular diseases move in differing directions over time suggests that other, unknown factors are involved as well. According to the researchers, post-enlistment weight trends may be one such factor, but stress and drug use may be others. Especially for heart attacks, researchers believe that a sharp fall in smoking underlies the decline. The fact remains, however, that overweight and obesity are influential. "We see that heart attacks would have decreased even more if it hadn't been for the rise in overweight and obesity. Our results thus provide strong support for thinking that obesity and, to some extent, low fitness by the age of 18 affect early-onset cardiovascular disease. So at societal level, it's important to try to get more physical activity, and to have already established good eating habits by adolescence, while being less sedentary," David Åberg concludes. Clinical trial shows benefit of yoga for side effects of prostate cancer treatment University of Pennsylvania, April 7, 2021 Men who attended a structured yoga class twice a week during prostate cancer radiation treatment reported less fatigue and better sexual and urinary function than those who didn't, according to a clinical trial led by the Perelman School of Medicine at the University of Pennsylvania. It is the first randomized trial to look at the effect of twice-weekly yoga on the side-effects and quality of life issues caused by prostate cancer treatment. The results published in the International Journal of Radiation Oncology, Biology, and Physics. All of the patients in the trial underwent between six and nine weeks of external beam radiation therapy for prostate cancer. The patients were randomized into two groups: one arm participated in a yoga class that met twice a week and the other arm served as a control group. Patients who already practiced yoga on their own were not eligible for the study, nor were patients with a history of prior radiation therapy or those with metastatic disease. Only two instructors led classes for this study, with the lead instructor teaching 75 percent of the classes. Each session lasted 75 minutes, beginning with five minutes of breathing and centering techniques and ending with five minutes of Savasana, a common yoga position. Typical sessions incorporated sitting, standing, and reclining positions that were modified using props to adapt to each patient's needs and restrictions. Patients were primarily evaluated on their level of fatigue. Each man filled out a nine-item questionnaire assessing fatigue severity and impact on daily life. The first questionnaire was given between two and three weeks before the start of radiotherapy, then twice a week while receiving radiotherapy, with a final survey filled out within a week of their last yoga class or last radiation treatment, depending on the assigned study arm. "At their baseline, before patients started treatment, patients in both groups were on the lower end of the scale, meaning they reported lower amounts of fatigue," said the trial's principal investigator Neha Vapiwala, MD, an associate professor of Radiation Oncology. "But as treatment went on, we observed a difference in the two groups." Patients in the yoga group reported lower fatigue scores over time, as they attended more yoga sessions, relative to where they started. Patients who did not participate in yoga trended in the opposite direction, reporting greater fatigue as treatment progressed. "Levels of patient-reported fatigue are expected to increase by around the fourth or fifth week of a typical treatment course, but that did not happen in the yoga group," Vapiwala said. "Both the severity of the fatigue as well as the patients' ability to go about their normal lives appeared to be positively impacted in the yoga group." Researchers also evaluated both groups in terms of their sexual health. Sexual dysfunction - including but not limited to erectile dysfunction (ED) - is reported by up to 85 percent of radiation therapy patients during treatment, often due to the concurrent use of androgen deprivation therapy (ADT). The study utilized the International Index of Erectile Function (IIEF) questionnaire, in which scores range from 0-25. Scores greater than 21 are considered normal and scores below 12 indicate moderate to severe ED. Both groups started out with scores of around 11, and were balanced in terms of ADT exposure; but while the yoga group's score ended up largely unchanged from baseline, the non-yoga group saw a decline over the course of treatment. "Yoga is known to strengthen pelvic floor muscles, which is one of several postulated theories that may explain why this group did not demonstrate declining scores, as seen in the control group," Vapiwala said. "That may also explain the yoga patients' improved urinary function scores, another finding of this trial." Vapiwala pointed out that the findings on improved or stable urinary function are consistent with other research on the effects of physical therapy on pelvic floor muscles. The trial also found that while the emotional well-being of both groups increased as patients progressed through treatment, the evaluation scores in the yoga group rose more rapidly than in the control group. An evaluation of physical well-being showed a similar pattern Spanking may affect the brain development of a child Study shows it could alter a child's neural responses to their environment in similar ways to a child experiencing more severe violence Harvard University, April, 12, 2021 Spanking may affect a child's brain development in similar ways to more severe forms of violence, according to a new study led by Harvard researchers. The research, published recently in the journal Child Development, builds on existing studies that show heightened activity in certain regions of the brains of children who experience abuse in response to threat cues. The group found that children who had been spanked had a greater neural response in multiple regions of the prefrontal cortex (PFC), including in regions that are part of the salience network. These areas of the brain respond to cues in the environment that tend to be consequential, such as a threat, and may affect decision-making and processing of situations. "We know that children whose families use corporal punishment are more likely to develop anxiety, depression, behavior problems, and other mental health problems, but many people don't think about spanking as a form of violence," said Katie A. McLaughlin, John L. Loeb Associate Professor of the Social Sciences, director of the Stress & Development Lab in the Department of Psychology, and the senior researcher on the study. "In this study, we wanted to examine whether there was an impact of spanking at a neurobiological level, in terms of how the brain is developing." According to the study's authors, corporal punishment has been linked to the development of mental health issues, anxiety, depression, behavioral problems, and substance use disorders. And recent studies show that approximately half of parents in U.S. studies reported spanking their children in the past year and one-third in the past week. However, the relationship between spanking and brain activity has not previously been studied. McLaughlin and her colleagues--including Jorge Cuartas, first author of the study and a doctoral candidate in the Harvard Graduate School of Education, and David Weissman, a post-doctoral fellow in the Department of Psychology's Stress & Development Lab--analyzed data from a large study of children between the ages of three and 11. They focused on 147 children around ages 10 and 11 who had been spanked, excluding children who had also experienced more severe forms of violence. Each child lay in an MRI machine and watched a computer screen on which were displayed different images of actors making "fearful" and "neutral" faces. A scanner captured the child's brain activity in response to each kind of face, and those images were analyzed to determine whether the faces sparked different patterns of brain activity in children who were spanked compared to those who were not. "On average, across the entire sample, fearful faces elicited greater activation than neutral faces in many regions throughout the brain... and children who were spanked demonstrated greater activation in multiple regions of PFC to fearful relative to neutral faces than children who were never spanked," researchers wrote. By contrast, "(t)here were no regions of the brain where activation to fearful relative to neutral faces differed between children who were abused and children who were spanked." The findings are in line with similar research conducted on children who had experienced severe violence, suggesting that "while we might not conceptualize corporal punishment to be a form of violence, in terms of how a child's brain responds, it's not all that different than abuse," said McLaughlin. "It's more a difference of degree than of type." Researchers said the study is a first step towards further interdisciplinary analysis of spanking's potential effects on children's brain development and lived experiences. "These findings aligned with the predictions from other perspectives on the potential consequences of corporal punishment," studied in fields such as developmental psychology and social work, said Cuartas. "By identifying certain neural pathways that explain the consequences of corporal punishment in the brain, we can further suggest that this kind of punishment might be detrimental to children and we have more avenues to explore it." However, they noted that their findings are not applicable to the individual life of each child. "It's important to consider that corporal punishment does not impact every child the same way, and children can be resilient if exposed to potential adversities," said Cuartas. "But the important message is that corporal punishment is a risk that can increase potential problems for children's development, and following a precautionary principle, parents and policymakers should work toward trying to reduce its prevalence." Ultimately, added McLaughlin, "we're hopeful that this finding may encourage families not to use this strategy, and that it may open people's eyes to the potential negative consequences of corporal punishment in ways they haven't thought of before."
In this edition of the Business Day Spotlight, we talk about small business funding with a venture capital fund. Our host Mudiwa Gavaza is joined by the team from Hlayisani Growth Fund (HGF): Dr Reuel Khoza, chairman and Dr Eugene van Rensburg, a partner. HGF is an investment firm that has raised R350m to invest in small, technology backed businesses that have the potential for high growth. The discussion centres around the rationale for creating HGF, what the main thrust will be for the fund, problems of raising capital for small businesses, the investment philosophy and thesis for HG, and what type of businesses they are looking to invest in?
Ainda no programa de hoje: quase 4.900 vidas já foram perdidas no Ceará por causa do novo coronavírus; sistema drive-thru para testagem da Covid-19 começa a operar no HGF; número de mortes violentas dobra durante o mês de maio no Ceará.
Lockdown has disrupted life for everyone. But for students revising for exams that have been cancelled for 12 months, it has delayed a vital stage of their professional development. Co-hosts Lee Davies and Gwilym Roberts speak with three student patent attorneys: Carolyn Palmer of Schlich who is Honorary Secretary of the CIPA Informals (an informal association of all trainees and a committee of CIPA); Kevin Rich of Potter Clarkson and Joel Briscoe of HGF. They discuss the frustrations of having a year added to their training and call on the Patent Examination Board to introduce online examinations, in line with many other legal professions. We also learn that Lee's tortoise, Albert Treacle, is trying to mate with an old pair of Crocs™.
To be fair, ‘Isn’t It Romantic’ is a charming flick full of laugh out loud moments and clever wit; however, to say the film lacks irony would be an understatement. *Spoiler alert* For instance, when contrasting real life to rom coms, our protagonist is clear she hates happy endings because they occur whenever convenient for the plot and conceal more than they reveal. The funny thing: This is exactly what ‘Isn’t It Romantic’ does on the issue of self-love which begs the question… Does self-love actually exist? As I discuss in this episode, the answer can’t be addressed in a vacuum. While secular voices can only go so far in their quest not to offend, one must wonder if we, as a culture, are synonymizing love and esteem as much as we are love and tolerance… YouTube: https://youtu.be/I91ERlvGgRM For more HGF podcasts, click here: https://hisgirlfryday.com/podcasts
Ever heard of the Hope Global Forums? If not, this is the perfect time to learn about it. Do NOT miss this next year! Here's three fun and quick convos with participants - 2 of whom are first-timers (just like me) and one whose been to EVERY one since they started nearly a decade ago. Amazing!! Plus, we included star-power snippets from some of the celebrities who graced the stage at the event with Hope Global Forums founder John Hope Bryant. [ Plus, we throw in some bonus admirable points on branding and experience about the event - for you event planners out there ]. Check out our lineup of interviews and snippets below: 4:16 Jay Hicks, Global Asset Development - first-timer at HGF 8:08 Laura Sims, Operation Hope - first-timer at HGF 13:35 Tony Ressler, Atlanta Hawks Owner 14:36 Judy J. Chapa, Chapa Consulting - experienced HGF attendee interviews ME about ADS! 27:03 Jack Dorsey, CEO & Co-Founder of both Square & Twitter 33:01 My takeaways on Jack Dorsey's daily 5 miles
Warten - Daniel Queißer - 17 12 2017 HGF by Landeskirchliche Gemeinschaft
Stuart Yuspa explains how increased signaling through the tyrosine kinase receptor MET promotes squamous cell carcinoma.
Multiple Sclerosis Discovery: The Podcast of the MS Discovery Forum
[intro music] Host – Dan Keller Hello, and welcome to Episode Sixty-One of Multiple Sclerosis Discovery, the Podcast of the MS Discovery Forum. I’m Dan Keller. In this podcast, Dr. Yanming Wang of Case Western Reserve University in Cleveland, Ohio, discusses a solution to the vexing problem of how to track changes in myelin in the brain and spinal cord, a measurement believed to be especially important for new candidate drugs to restore this insulating sheathing around axons. First, here are some new items in the MS Discovery Forum. A new data visualization showcases the collaborations among authors who published papers reporting the results of clinical trials in progressive forms of multiple sclerosis in the last 30 years. You can find the network map on msdiscovery.org under “Research Resources.” You can mouse over circles in the graphic to find researchers' names. Click and drag the circles to animate the map and reveal connections. In research news, a Swedish team took the first steps toward finding potential disease markers in the immune cells of asymptomatic people with MS and with seasonal allergies. The study pinpointed three key proteins that may transform normally protective T cells into ones that attack myelin in the case of MS. The three proteins are transcription factors, which glom on to DNA and control which genes turn on and off. According to data from genome studies, the proteins are more common in genetic regions associated with disease, strengthening the case for their role in MS. Finally, the three proteins act differently in people with immune-related diseases, including multiple sclerosis, according to tests on blood samples. Ultimately, the researchers want to learn if they can detect multiple sclerosis and other autoimmune conditions much earlier. [transition music] And now to our interview. MSDF caught up with Dr. Yanming Wang last month at the 2015 World Congress of Neurology meeting in Santiago, Chile. We discussed his solution to what has been a missing link in MS research and practice; that is, how to image myelin -- not just lesions on an MRI, but how to tag the substance itself using a biomarker for molecular imaging called M-E-D-A-S, or "mee-das." Going beyond diagnosis, Dr. Wang told us it may eventually allow clinicians to get a better handle on disease progression and efficacy of treatments. Interviewer – Dan Keller You had referred to molecular imaging of myelin as the missing link. Why is this the missing link? Interviewee – Yanming Wang Because molecular imaging has really transformed how we practice medicine today, and it has become a standard care for virtually many neurological diseases. However, in multiple sclerosis, there's still no effective imaging technique in place that can help physicians to monitor not just for diagnosis, but also to monitor the disease progression. MSDF And would this be useful also in monitoring potential therapies? Dr. Wang Exactly. There's a lack of imaging technique that allow people to monitor the drug efficacy, particularly for those drugs that try to repair the myelin damage in the CNS. MSDF How would this differ from MRI imaging, what you see there, versus having a radioactive biomarker? Dr. Wang Currently, MRI is the commonly used imaging modality in MS, however MRI provides only anatomical information and also detect brain lesions. However, those lesions detected on MRI are not specific for myelin pathology. MSDF You do have a compound now, [11C]MeDAS, which would be specific for myelin. Is that right, is it very specific for myelin? Dr. Wang Exactly. It's very specific for myelin, because the advantage it has over MRI is that that is truly a molecular imaging modality which uses myelin-specific radiotracers that allow to quantitatively monitor the myelin damage and myelin distribution in the brain. So for this reason, we developed a specific radiotracer that can selectively bind to myelin with high affinity, so that we could directly image the myelin distribution. MSDF How quickly does it reach the CNS and you can image? Dr. Wang It takes minutes, literally, for the radiotracer to penetrate the BBB and enter the brain, and then the whole process takes only 60 minutes. MSDF Can you briefly describe your rat model where you're using lysolecithin as an MS model, and then what you did with your marker? Dr. Wang Lysolecithin model is an established model of focal demyelination in the brain, so we used that model to test our compounds to monitor the demyelination and remyelination. So after injection of MeDAS, the compounds could readily enter the brain and selectively bind to the myelin. And then at the peak of the disease, which is a peak of the demyelination, the brain uptake of the compounds is lowest, versus when the brain is recovered, then the brain uptake of the compounds is increased. So this demonstrated the in vivo specificity of the radiotracer for myelin. MSDF And you can image myelin on the way down and on the way up; you have this hepatocyte growth factor which causes some remyelination? Dr. Wang Right, exactly. In collaboration with my colleague, Bob Miller. So we'd use this imaging modality to see if we can monitor the drug efficacy for remyelination. So we'd give this HGF, which is a growth factor that promotes remyelination, and then we could use this imaging technique just to monitor the increase of remyelination after the drug treatment. MSDF Everything right now is in animals. Do you have plans for any human trials? Dr. Wang Yes, we are working on this paperwork required by FDA to put these compounds in humans. MSDF Is the compound so far nontoxic; it's diamino stilbene, is that right? Does it have any estrogenic effects or other toxic effects? Dr. Wang No. We have done systematic toxicity studies and there's any adverse effects in animal models so far. MSDF What do you see as the clinical utility of this if it enters the human realm? Dr. Wang It's going to be a very powerful tool for diagnosis and prognosis, and also particularly for evaluation of drug efficacy. As you know, currently pharmaceutical companies and academic investigators are all trying to develop new drugs that can repair myelin damage in order to restore the biological functions. However, there's a lack of imaging tools in place that allow them to monitor such myelin repair therapies, and this could provide the missing link for this endeavor. MSDF Does PET imaging with this compound correlate at all with what's seen on MRI, especially in a kinetic sense following time course? Dr. Wang Well, yes. In the wonderful publication in Annual Neurology a couple years ago, we did demonstrate that this PET imaging technique can be used as an imaging marker that correlates with the disease progression in terms of the severity of the symptoms in animal models, in the EAE models. The EAE rat, for example, its appearance, the relapsing or remitting stage, and that we could use this imaging marker to correlate nicely with the symptoms. And this is one of important application if we put this into clinical use. MSDF Is this compound the end-all and be-all, or are you developing others, or have some gone by the wayside for various reasons? Dr. Wang This compound, and also this imaging technique, could be used not just only in MS, but can also be used in many other neurological diseases, such as Alzheimer's disease, spinal cord injury, and stroke, for example, because all of these neurological diseases are associated to some degree with the myelin damage. MSDF Have we missed anything important, anything to add? Dr. Wang Again, I think the imaging technique, particularly molecular imaging technique based on positron emission tomography, is lagged behind in the field of neurological diseases because of the complexities of the brain and the lack of molecular probes that could advance our understanding, also facilitate the drug discovery. MSDF I appreciate it. Thank you. Dr. Wang Oh, thank you very much then. [transition music] MSDF Thank you for listening to Episode Sixty-One of Multiple Sclerosis Discovery. This Podcast was produced by the MS Discovery Forum, MSDF, the premier source of independent news and information on MS research. MSDF’s executive editor is Carol Cruzan Morton. Heather McDonald curated the MSDF drug database updates. Msdiscovery.org is part of the nonprofit Accelerated Cure Project for Multiple Sclerosis. Robert McBurney is our President and CEO, and Hollie Schmidt is Vice President of Scientific Operations. Msdiscovery.org aims to focus attention on what is known and not yet known about the causes of MS and related conditions, their pathological mechanisms, and potential ways to intervene. By communicating this information in a way that builds bridges among different disciplines, we hope to open new routes toward significant clinical advances. We’re interested in your opinions. Please join the discussion on one of our online forums or send comments, criticisms, and suggestions to editor@msdiscovery.org. For Multiple Sclerosis Discovery, I'm Dan Keller. [outro music]
Medizinische Fakultät - Digitale Hochschulschriften der LMU - Teil 16/19
Mesenchymale Stammzellen (MSCs) besitzen eine Vielzahl einzigartiger Eigenschaften, hierunter ihr Differenzierungs- und immunregulatorisches Potenzial, die sie sehr interessant für die biomedizinische Forschung machen. Ziel der vorliegenden Arbeit war es zu untersuchen, welche Mechanismen der immunmodulierenden Wirkung der MSCs zugrunde liegen. Zu diesem Zweck wurden mesenchymale Stammzellen aus dem Knochenmark von 5-16 Wochen alten Balb/c-Mäusen isoliert und in der Zellkultur expandiert. Das Oberflächenmarkerprofil der Zellen wurde durch Durchflusszytometrie (FACS) charakterisiert und die Expression potenziell immunsuppressiver Faktoren durch ELISA, Reverse Transkriptase-PCR beziehungsweise Western-Blot bestimmt. Für die Untersuchung der MSC-vermittelten Immunmodulation wurde ein Proliferationsassay etabliert, in dem Lymphozyten aus C57Bl/6-Mäusen durch das Mitogen ConA stimuliert und mit den murinen MSCs kokultiviert wurden. Durch die Zugabe spezifischer Inhibitoren gegen TGFβ, die Prostaglandin E2-Synthese (Indomethacin), den HGF-Rezeptor und den Adenosinrezeptor (SCH58261) wurde die Vermittlung der immunmodulierenden Effekte durch die MSCs untersucht. In der Studie konnte eine reine Population muriner MSCs mit charakteristischen Oberflächenmarkern (CD29, CD73, CD90, CD105, CD140b, Sca-1) expandiert werden, die in vitro starke immunsuppressive Effekte im Proliferationsassay aufwies. Die Untersuchungen potenzieller Effektormoleküle zeigten, dass bei den murinen MSCs TGFβ, HGF und das Enzym IDO keine entscheidende Rolle spielten und von den bekannten Mechanismen vor allem die Produktion von PGE2 die Lymphozytenproliferation hemmte. Als wichtigstes Ergebnis kann der Nachweis, dass die murinen MSCs die Ektonukleotidasen CD39 und CD73 koexprimieren, die extrazelluläres ATP über 5’-AMP in das extrem stark immunsuppressiv wirkende Adenosin konvertieren können, angesehen werden. Zusammenfassend wurde in der vorliegenden Arbeit erstmals die Expression von CD39 auf murinen MSCs beschrieben. Die Koexpression von CD39/CD73 auf den MSCs und die daraus folgende Produktion von Adenosin stellt einen neuen Ansatz dar, um die Funktion der MSCs besser zu verstehen. Die CD39+/CD73+-MSCs sind demnach eine vielversprechende Zellpopulation für die Behandlung von Autoimmunerkrankungen und für die Entwicklung neuer lokaler oder systemischer Therapien zur Toleranzinduktion nach Transplantation.
MET is the only known receptor for hepatocyte growth factor (HGF). Activation of the MET receptor by HGF binding triggers a large, multistep, tightly regulated and intricated signal transduction cascade. These signalling events also culminate in initiating almost all cellular processes defining the malignant phenotype. The goal of this V-learning module is to provide a scientific overview of the multidomain structure of MET and HGF, milestones in MET and HGF discoveries, to show signalling cascade and subsequently triggered processes in an animated model to enhance understanding, to provide an update on dysregulation of the MET signalling pathway which occurs in a wide range of human cancers, to review selected MET inhibitors and their inhibitory targets in the MET pathway, and provide a scientific rationale on data from recent clinical studies in different tumour types, but with a special emphasis on non-small cell lung cancer.
Epidemiological studies have indicated a relationship between coronary heart disease (CHD) and periodontitis. Recently, CDKN2BAS was reported as a shared genetic risk factor of CHD and aggressive periodontitis (AgP), but the causative variant has remained unknown. To identify and validate risk variants in different European populations, we first explored 150 kb of the genetic region of CDKN2BAS including the adjacent genes CDKN2A and CDKN2B, covering 51 tagging single nucleotide polymorphisms (tagSNPs) in AgP and chronic periodontitis (CP) in individuals of Dutch origin (n=313). In a second step, we tested the significant SNP associations in an independent AgP and CP population of German origin (n=1264). For the tagSNPs rs1360590, rs3217992, and rs518394, we could validate the associations with AgP before and after adjustment for the covariates smoking, gender and diabetes, with SNP rs3217992 being the most significant (OR 1.48, 95% CI 1.19 to 1.85; p=0.0004). We further showed in vivo gene expression of CDKN2BAS, CDKN2A, CDKN2B, and CDK4 in healthy and inflamed gingival epithelium (GE) and connective tissue (CT), and detected a significantly higher expression of CDKN2BAS in healthy CT compared to GE (p=0.004). After 24 h of stimulation with Porphyromonas gingivalis in Streptococcus gordonii pre-treated gingival fibroblast (HGF) and cultured gingival epithelial cells (GECs), we observed a 25-fold and fourfold increase of CDKN2BAS gene expression in HGFs (p=0.003) and GECs (p=0.004), respectively. Considering the global importance of CDKN2BAS in the disease risk of CHD, this observation supports the theory of inflammatory components in the disease physiology of CHD.
Medizinische Fakultät - Digitale Hochschulschriften der LMU - Teil 06/19
Unter den Prognosefaktoren beim kolorektalen Karzinom hat das Tumorstaging den größten Stellenwert und dient der weiteren Therapieplanung. In den letzten Jahren wurden zunehmend auch Tumormarker hinsichtlich der prognostischen Aussagekraft untersucht, es existieren aber kaum Studien, die an großer Fallzahl mehrere Tumormarker im Vergleich zu den etablierten Prognosefaktoren multivariat evaluiert haben. In der vorliegenden Arbeit wurden die Tumormarker CEA, CA 19-9, CA 242, CA 72-4, CYFRA 21-1, hCGß, S100 und HGF hinsichtlich ihrer prognostischen Wertigkeit beim kolorektalen Karzinom analysiert. Die präoperativen Tumormarkerwerte von CEA und CA 19-9 lagen bei 1089 Patienten (Kollektiv I) vor. Bei einem Teil dieser Patienten (n=450) waren Restproben vorhanden, so dass retrospektiv zusätzlich die Tumormarker CA 242, CA 72-4, CYFRA 21-1, hCGß, S100 und HGF analysiert werden konnten (Kollektiv II). Es zeigte sich bei allen Tumormarkern eine höhere Freisetzung mit zunehmender Tumorinfiltrationstiefe. Bei CEA und CA 19-9 wurde außerdem ein signifikanter Zusammenhang zwischen der Serumkonzentration und dem Lymphknotenstatus festgestellt. Bezüglich der Korrelation der Tumormarker untereinander wurde der höchste Koeffizient für CA 19-9 und CA 242 errechnet (rs=0.79). Basierend auf den aktuellen Empfehlungen für adjuvante Therapien beim kolorektalen Karzinom wurde eine Unterteilung in Prognosegruppen vorgenommen: In der günstigen Prognosegruppe (GPG) befanden sich Patienten mit einem Kolonkarzinom Stadium I-II oder Rektumkarzinom Stadium I, in der ungünstigen Prognosegruppe (UPG) befanden sich Patienten mit einem Kolonkarzinom Stadium III oder einem Rektumkarzinom Stadium II oder III. In Anlehnung an eine Studie von Harrison et al wurden zusätzlich alle Patienten mit einem Kolonkarzinom ohne Lymphknotenbefall gesondert betrachtet. Ziel unserer Studie war es zu untersuchen, ob durch Berücksichtigung von Tumormarkern innerhalb der Prognosegruppen eine detailliertere prognostische Einschätzung mit entsprechender therapeutischer Konsequenz erfolgen kann. Dabei war unser primäres Zielkriterium das rezidivfreie Intervall, zusätzlich untersuchten wir das tumorbedingte Gesamtüberleben. 161 In der statistischen Auswertung wurde zunächst überprüft, ob eine lineare Abhängigkeit zwischen der Serumkonzentration der Tumormarker und dem Rezidivrisiko besteht. Eine solche Linearität konnte nur für CEA gezeigt werden, es ging daher in logarithmierter Form in die multivariate Analyse ein. Bei den übrigen Tumormarkern musste ein Cut-Off gesucht werden, wobei in der vorliegenden Arbeit weder die herstellerüblichen Cut-Off-Werte verwendet wurden, noch nach dem für das Kollektiv optimalen Cut-Off gesucht wurde. Vielmehr wurde versucht, mittels Bootstrapverfahren reproduzierbare Cut-Offs zu ermitteln. Nach unseren Ergebnissen ist CEA zu Recht als Kategorie I Prognosemarker klassifiziert worden. Dies konnte an großer Fallzahl und unter Berücksichtigung verschiedener anderer Tumormarker bestätigt werden. Auch in der Gruppe der Patienten mit einer günstigen Prognose sowie der N0-Kolontumoren erwies sich CEA als unabhängiger Prognosefaktor. Die Patienten dieser Gruppen erhalten laut dem aktuellen Konsensus keine adjuvante Therapie. Basierend auf den Ergebnissen dieser Arbeit sollte CEA jedoch in den Leitlinien der American Society of Clinical Oncology als prognostisch relevanter Parameter berücksichtigt werden und auch in die Therapieplanung mit eingehen. In der multivariaten Analyse hat sich darüber hinaus beim Kollektiv I gezeigt, dass neben CEA auch CA 19-9 ein stadienunabhängiger Prognosefaktor ist, jedoch nur für die ungünstige Prognosegruppe. Innerhalb des Kollektivs II erreichten die Tumormarker CEA, CA 19-9, CA 242, CA 72-4, S100 und HGF Signifikanz. Die beiden neuen und wenig erforschten Tumormarker S100 und HGF waren starke unabhängige Prädiktoren in der günstigen Prognosegruppe dieser Auswertung, sogar stärker als CEA. Dieses Ergebnis muss durch prospektive große Studien bestätigt werden. Im Gegensatz zu S100 erreichte HGF auch in der ungünstigen Prognosegruppe Signifikanz, war aber bezüglich der prognostischen Aussagekraft dem CA 242 bzw. CA 19-9 unterlegen. Gerade im Rahmen kommender Therapiestudien, bei denen der Einfluss neuer Medikamente auf die Angiogenese untersucht wird, könnte HGF von grossem Interesse sein. Der Tumormarker CA 242 kann als äquivalenter Marker zum CA 19-9 gesehen werden, so dass die parallele Bestimmung beider Tumormarker primär nicht sinnvoll ist. CA 72-4 erreichte in der uni- und multivariaten Analyse nur für das Überleben innerhalb der ungünstigen Prognosegruppe Signifikanz. 162 Die beiden Tumormarker hCGß und CYFRA 21-1 zeigten in dieser Arbeit keinerlei prognostische Bedeutung. Um unsere Ergebnisse für die klinische Anwendung zusammenzufassen, wurde für alle prognostisch relevanten Faktoren ein Prognoseindex entwickelt und zwar zunächst anhand des großen Kollektivs I. In der günstigen Prognosegruppe beinhaltet dieser Score derzeit lediglich T und logCEA, in der ungünstigen Prognosegruppe T, N, Lokalisation des Primärtumors, logCEA und CA 19-9 (Cut-off 55 U/ml). Eine Einteilung der Patienten bezüglich dieser Prognose-Scores zeigt eine deutliche Überlappung der ursprünglichen Prognosegruppen im Bezug auf das rezidivfreie Intervall. Daraus geht eindeutig hervor, dass die Bestimmung und Bewertung beider Tumormarker, also von CEA und von CA 19-9, sinnvoll ist und eine sehr viel genauere Prognoseabschätzung ermöglicht.
Fakultät für Biologie - Digitale Hochschulschriften der LMU - Teil 02/06
Hepatocyte Growth Factor (HGF) is a pleiotropic factor acting on cells expressing the Met receptor tyrosine kinase. HGF/Met signaling has been described in detail and it is known to control cell migration, growth and differentiation in several embryonic organs and to be implicated in human cancer. Conversely, little is known about the transcriptional targets that lead to Met-mediated biological functions. Also, little is known about the physiological mechanisms that attenuate Met signaling. This work provides the results of a screen for genes transcriptionally regulated by Met in several cell lines and addresses the functions of the highly inducible gene Mig6 (Mitogen-inducible-gene6, also called Gene 33 and RALT). By the use of Met loss of function mutant mice Met is shown to be the major inducer of mig6 in hepatocytes and lungs of E13.5 embryos. Mig6 is shown in turn to negatively regulate HGF/Met-induced cell migration. The effect is observed by Mig6 overexpression and reversed by Mig6 siRNA knock down experiments indicating that endogenous Mig6 is part of a mechanism that inhibits Met signaling. Mig6 functions in cells of hepatic origin and in neurons suggesting a role for Mig6 in different cell lineages. Mechanistically, Mig6 requires an intact Cdc42/Rho interactive binding (CRIB) domain to exert its inhibitory action suggesting that Mig6 acts at least in part distally from Met possibly by sequestering Rho-like GTPases. Because Mig6 is also induced by HGF stimulation, this work provides evidence that Mig6 is part of a negative feedback loop that attenuates Met functions in different contexts and cell types.
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