Podcasts about exeter medical school

Aphantasia is the inability to see with your mind's eye. And its discovery has made scientists ask a surprising question: What is the mind's eye even for? (First published in 2022.) Guests: Alice Coles, artist; Adam Zeman, cognitive neurologist at the University of Exeter Medical School; Joel Pearson, professor of neuroscience at the University of New South Wales; Emily Holmes, professor of psychology at Uppsala University For show transcripts, go to ⁠⁠⁠vox.com/unxtranscripts⁠⁠⁠ For more, go to ⁠⁠⁠vox.com/unexplainable⁠⁠⁠ And please email us! ⁠⁠unexplainable@vox.com⁠⁠ We read every email. Support Unexplainable (and get ad-free episodes) by becoming a Vox Member today: ⁠⁠⁠vox.com/members Learn more about your ad choices. Visit podcastchoices.com/adchoices

This episode focuses on monogenic diabetes, diabetes research, and inspiring the next generation of nurses. Jonathan is joined by Maggie Shepherd, Honorary Clinical Professor at the University of Exeter Medical School, UK. The pair explore how we can strengthen the research influence of nurses, including the 70@70 programme, as well as Shepherd's initiatives to encourage a career in nursing and research in nursing. Use the following timestamps to navigate our episode! (00:00)-Introduction  (03:43)-Entering into diabetes research (04:27)-Monogenic diabetes  (07:01)-70@70 initiative  (11:00)-Aster Guardians Global Nursing award (12.32)-Successes, challenges, and opportunities in monogenic diabetes (14:48)-Patient care during COVID-19  (17:30)-‘1 in 6 Billion' podcast (19:56)-Inspiring the next generation (23:09)-Maggie's wishes for the future of healthcare 

This is Garrison Hardie with your CrossPolitic Daily News Brief for Friday, December 1st, 2023. Pub Membership Plug: Public Houses, or Pubs, are not just places to drink beer, wine, cider or even something a little stronger. It is also a unique social centre, very often the focus of community life in villages, towns and cities throughout the length and breadth of the world. We here at CrossPolitic hope to emulate that for you and yours. That’s why you should grab yourself a pub membership at fightlaughfeast.com… we need you on this ride with us. So pull up a chair, grab a pint, and join us on this ride at fightlaughfeast.com - that’s fightlaughfeast.com. https://www.theblaze.com/news/damning-study-suggests-pandemic-lockdowns-accelerated-significant-memory-and-cognitive-decline-in-seniors Damning study suggests pandemic lockdowns accelerated 'significant' memory and cognitive decline in seniors The lockdowns and societal restrictions championed by teachers' unions and other leftists during the pandemic were not just ruinous for the mental health of children and teens. A new study out of the U.K. indicates pandemic restrictions also had a deleterious impact on the minds of the elderly. Dr. Anne Corbett of the University of Exeter Medical School and her team examined neuropsychology data from 3,142 individuals, all 50 years of age or over, who had been participating in a multi-decade dementia study in Britain. The researchers compared data on this cohort collected before the pandemic, early in the pandemic, then once more toward the tail end of the pandemic. The researchers observed "[s]ignificant worsening of executive function and working memory" in the first year of the pandemic across the whole cohort, the average age of which was 67.5. Working memory continued to worsen across the whole cohort in the second year of the pandemic. By the time restrictions had ultimately been eased, the damage had been done. According to the study, cognitive decline was significantly associated with reduced exercise and increased drinking across the whole cohort. Depression, another driving factor of cognitive decline, was notable amongst those who contracted COVID-19. Loneliness proved especially detrimental to those with mild cognitive impairment. "People aged 50 years and older in the UK had accelerated decline in executive function and working memory during the first year of the COVID-19 pandemic, during which the UK was subjected to three societal lockdowns for a total period of 6 months," said the study, published in the Lancet journal Healthy Longevity. The British government, which funded this study via the National Institute for Health and Care Research, not only limited the number of times citizens could exercise outside during the pandemic, but shuttered gyms, golf courses, sports courts, swimming pools, and indoor sports facilities. "The scale of change is also of note, with all groups—the whole cohort and the individual subgroups—showing more than a 50% greater decline in working memory and executive function and many effect sizes reaching a clinically significant threshold of greater than 0·3," said the researchers. The researchers further stressed that "[t]hese factors map closely to the population-wide changes in health and lifestyle seen during and after the lockdowns, raising the important question of the effect of the pandemic on cognitive health and risk across populations." https://www.foxnews.com/politics/appeals-court-reinstates-gag-order-trump-fraud-case Appeals court reinstates gag order in Trump fraud case A New York appeals court reinstated a gag order preventing former President Donald Trump from maligning court staffers on Thursday. New York Judge Arthur Engoron had initially issued the gag order in early October after Trump lashed out at one of his law clerks on social media. Trump is currently fighting accusations of business fraud leveled by New York Attorney General Letitia James. Appeals court Judge David Friedman had issued a stay on Engoron's gag order on Nov. 16, saying it potentially infringed on Trump's First Amendment rights. By that time, Engoron had already fined Trump $5,000 for violating the order on social media on Oct. 20, and did so again on Oct. 25 for another $10,000 before threatening imprisonment if further violations were committed. Trump took the stand to testify personally in early November. He repeatedly cast James’ yearslong investigation and lawsuit as a "disgrace" and an attack on his business and his family. Trump has denied any wrongdoing and insists his assets were actually undervalued. Trump has repeatedly said his financial statements had disclaimers requesting that the numbers be evaluated by the banks. Engoron ruled in September that both Trump and his company had committed fraud by deceiving banks, insurers and others by overvaluing his assets and exaggerating his net worth on paperwork used in making deals and securing financing. Trump has attacked Engoron and James — both Democrats — as politically biased "operatives." "They are defending the Worst and Least Respected Attorney General in the United States, Letitia James, who is a Worldwide disgrace, as is her illegal Witch Hunt against me. The Radical and Unprecedented actions of Judge Engoron will keep BUSINESSES and JOBS forever out of New York State," Trump wrote in a recent social media post. https://www.justfactsdaily.com/1-in-every-39-americans-will-die-of-a-drug-overdose-at-current-rate 1 in Every 39 Americans Will Die of a Drug Overdose at Current Rate Despite the passage of state and federal laws that were supposed to reduce fatal drug overdoses, the annual U.S. drug overdose death rate has quintupled over recent decades: Over the most current year of available data, more than 110,000 people in the U.S. died of drug overdoses, a rate of 33 per 100,000 population. In order to measure these deaths in clear, relevant terms, Just Facts enlisted the expertise of a licensed actuary and a Ph.D. mathematician to calculate, double-check, and triple-check the average lifetime odds of dying of a drug overdose. The shocking result of these calculations is that 1 in 39 people will have their lives cut short by drug overdoses if the rate of such deaths stays at the current level. Those odds will become far worse if the rising trend continues. The lifetime risks of tragic events are much more revealing than the raw numbers or annual rates commonly reported by government agencies and the media. This is partly because the U.S. is the third-most populous nation in the world, so tens, hundreds, or even thousands of events may amount to a very low risk. The other reason, which is less obvious, is explained by a 1987 Department of Justice report on the likelihood of being a crime victim: Annual victimization rates alone do not convey the full impact of crime as it affects people. No one would express his or her concern by saying, “I am terribly afraid of being mugged between January and December of this year.” People are worried about the possibility that at some time in their lives they will be robbed or raped or assaulted, or their houses will be burglarized. Each month, the CDC estimates drug overdose deaths based on data reported by the 50 states and the District of Columbia. The latest estimates, which include deaths up through June 2023, show that 111,877 people died of a drug overdose in the prior 12 months. To place such figures into the broader context of the U.S. population and people’s lifespans, Just Facts asked a licensed actuary to develop a method for calculating the average lifetime risk of death from various causes. The actuary used two separate methods, both of which yielded the same results. To further ensure accuracy, Just Facts had a Ph.D. mathematician check the formulas. Applying this methodology to the CDC’s latest estimates of overdose deaths, roughly 1 in every 39 people will die of drug overdose if the rate of such deaths stays at its current level. Beyond lifetime risk, another important measure of a mortal danger is the years of life that it robs from its victims. Because humans cannot prevent death but only delay it, there is a material difference between the tragic premature deaths of a 20-year-old in the prime of her life and a 90-year-old in poor health. Although some leading medical scholars ignored that vital fact during the Covid-19 pandemic, a 1983 CDC report about fatal accidents explains that the “the allocation of health resources must consider not only the number of deaths by cause but also by age.” The average age of people who die of drug overdoses is about 43 years, while the average U.S. lifespan is about 77 years. In contrast, the average age of people whose deaths involved Covid-19 is about 75 years. Yet, government officials locked down entire states for extended periods to prevent the spread of Covid, causing multitudes of collateral deaths. This likely included overdoses, which soared in the wake of these measures. https://www.foxnews.com/sports/jets-aaron-rodgers-takes-big-step-hopeful-return-achilles-injury Jets' Aaron Rodgers takes big step in hopeful return from Achilles injury The New York Jets opened the 21-day practice window for Aaron Rodgers on Wednesday, sparking hope the quarterback could return this season just mere months after tearing his Achilles. Jets head coach Robert Saleh told reporters that it doesn’t necessarily mean Rodgers is going to come back and play, but is rather a "progression in his rehab." "For Aaron, what he would be doing in practice is no different than what he’d be doing on the field with regard to certain drills in the individual – instead of throwing with staff members, he’s throwing with teammates," Saleh told reporters. "There’s no added risk to it. There’s certain things he’s been cleared for that we’re going to allow him to do." Saleh lauded Rodgers’ drive and motivation for pushing himself to get back to where he is and the want and need for him to be with his teammates. "He’s sacrificed so much already for the organization and himself and his teammates and he’s doing it again. I think it’s a testament to who he is as a human," Saleh added. Rodgers’ timeline is still really unclear. He tried to lay it out the best he could in his appearance on "The Pat McAfee Show" this week. "Once I'm healthy, then it's where we're at, are we alive, are we in it… It's health first, and are we alive for the playoffs second.". New York is 4-7 entering Week 13 and their playoff hopes are dwindling.

This is Garrison Hardie with your CrossPolitic Daily News Brief for Friday, December 1st, 2023. Pub Membership Plug: Public Houses, or Pubs, are not just places to drink beer, wine, cider or even something a little stronger. It is also a unique social centre, very often the focus of community life in villages, towns and cities throughout the length and breadth of the world. We here at CrossPolitic hope to emulate that for you and yours. That’s why you should grab yourself a pub membership at fightlaughfeast.com… we need you on this ride with us. So pull up a chair, grab a pint, and join us on this ride at fightlaughfeast.com - that’s fightlaughfeast.com. https://www.theblaze.com/news/damning-study-suggests-pandemic-lockdowns-accelerated-significant-memory-and-cognitive-decline-in-seniors Damning study suggests pandemic lockdowns accelerated 'significant' memory and cognitive decline in seniors The lockdowns and societal restrictions championed by teachers' unions and other leftists during the pandemic were not just ruinous for the mental health of children and teens. A new study out of the U.K. indicates pandemic restrictions also had a deleterious impact on the minds of the elderly. Dr. Anne Corbett of the University of Exeter Medical School and her team examined neuropsychology data from 3,142 individuals, all 50 years of age or over, who had been participating in a multi-decade dementia study in Britain. The researchers compared data on this cohort collected before the pandemic, early in the pandemic, then once more toward the tail end of the pandemic. The researchers observed "[s]ignificant worsening of executive function and working memory" in the first year of the pandemic across the whole cohort, the average age of which was 67.5. Working memory continued to worsen across the whole cohort in the second year of the pandemic. By the time restrictions had ultimately been eased, the damage had been done. According to the study, cognitive decline was significantly associated with reduced exercise and increased drinking across the whole cohort. Depression, another driving factor of cognitive decline, was notable amongst those who contracted COVID-19. Loneliness proved especially detrimental to those with mild cognitive impairment. "People aged 50 years and older in the UK had accelerated decline in executive function and working memory during the first year of the COVID-19 pandemic, during which the UK was subjected to three societal lockdowns for a total period of 6 months," said the study, published in the Lancet journal Healthy Longevity. The British government, which funded this study via the National Institute for Health and Care Research, not only limited the number of times citizens could exercise outside during the pandemic, but shuttered gyms, golf courses, sports courts, swimming pools, and indoor sports facilities. "The scale of change is also of note, with all groups—the whole cohort and the individual subgroups—showing more than a 50% greater decline in working memory and executive function and many effect sizes reaching a clinically significant threshold of greater than 0·3," said the researchers. The researchers further stressed that "[t]hese factors map closely to the population-wide changes in health and lifestyle seen during and after the lockdowns, raising the important question of the effect of the pandemic on cognitive health and risk across populations." https://www.foxnews.com/politics/appeals-court-reinstates-gag-order-trump-fraud-case Appeals court reinstates gag order in Trump fraud case A New York appeals court reinstated a gag order preventing former President Donald Trump from maligning court staffers on Thursday. New York Judge Arthur Engoron had initially issued the gag order in early October after Trump lashed out at one of his law clerks on social media. Trump is currently fighting accusations of business fraud leveled by New York Attorney General Letitia James. Appeals court Judge David Friedman had issued a stay on Engoron's gag order on Nov. 16, saying it potentially infringed on Trump's First Amendment rights. By that time, Engoron had already fined Trump $5,000 for violating the order on social media on Oct. 20, and did so again on Oct. 25 for another $10,000 before threatening imprisonment if further violations were committed. Trump took the stand to testify personally in early November. He repeatedly cast James’ yearslong investigation and lawsuit as a "disgrace" and an attack on his business and his family. Trump has denied any wrongdoing and insists his assets were actually undervalued. Trump has repeatedly said his financial statements had disclaimers requesting that the numbers be evaluated by the banks. Engoron ruled in September that both Trump and his company had committed fraud by deceiving banks, insurers and others by overvaluing his assets and exaggerating his net worth on paperwork used in making deals and securing financing. Trump has attacked Engoron and James — both Democrats — as politically biased "operatives." "They are defending the Worst and Least Respected Attorney General in the United States, Letitia James, who is a Worldwide disgrace, as is her illegal Witch Hunt against me. The Radical and Unprecedented actions of Judge Engoron will keep BUSINESSES and JOBS forever out of New York State," Trump wrote in a recent social media post. https://www.justfactsdaily.com/1-in-every-39-americans-will-die-of-a-drug-overdose-at-current-rate 1 in Every 39 Americans Will Die of a Drug Overdose at Current Rate Despite the passage of state and federal laws that were supposed to reduce fatal drug overdoses, the annual U.S. drug overdose death rate has quintupled over recent decades: Over the most current year of available data, more than 110,000 people in the U.S. died of drug overdoses, a rate of 33 per 100,000 population. In order to measure these deaths in clear, relevant terms, Just Facts enlisted the expertise of a licensed actuary and a Ph.D. mathematician to calculate, double-check, and triple-check the average lifetime odds of dying of a drug overdose. The shocking result of these calculations is that 1 in 39 people will have their lives cut short by drug overdoses if the rate of such deaths stays at the current level. Those odds will become far worse if the rising trend continues. The lifetime risks of tragic events are much more revealing than the raw numbers or annual rates commonly reported by government agencies and the media. This is partly because the U.S. is the third-most populous nation in the world, so tens, hundreds, or even thousands of events may amount to a very low risk. The other reason, which is less obvious, is explained by a 1987 Department of Justice report on the likelihood of being a crime victim: Annual victimization rates alone do not convey the full impact of crime as it affects people. No one would express his or her concern by saying, “I am terribly afraid of being mugged between January and December of this year.” People are worried about the possibility that at some time in their lives they will be robbed or raped or assaulted, or their houses will be burglarized. Each month, the CDC estimates drug overdose deaths based on data reported by the 50 states and the District of Columbia. The latest estimates, which include deaths up through June 2023, show that 111,877 people died of a drug overdose in the prior 12 months. To place such figures into the broader context of the U.S. population and people’s lifespans, Just Facts asked a licensed actuary to develop a method for calculating the average lifetime risk of death from various causes. The actuary used two separate methods, both of which yielded the same results. To further ensure accuracy, Just Facts had a Ph.D. mathematician check the formulas. Applying this methodology to the CDC’s latest estimates of overdose deaths, roughly 1 in every 39 people will die of drug overdose if the rate of such deaths stays at its current level. Beyond lifetime risk, another important measure of a mortal danger is the years of life that it robs from its victims. Because humans cannot prevent death but only delay it, there is a material difference between the tragic premature deaths of a 20-year-old in the prime of her life and a 90-year-old in poor health. Although some leading medical scholars ignored that vital fact during the Covid-19 pandemic, a 1983 CDC report about fatal accidents explains that the “the allocation of health resources must consider not only the number of deaths by cause but also by age.” The average age of people who die of drug overdoses is about 43 years, while the average U.S. lifespan is about 77 years. In contrast, the average age of people whose deaths involved Covid-19 is about 75 years. Yet, government officials locked down entire states for extended periods to prevent the spread of Covid, causing multitudes of collateral deaths. This likely included overdoses, which soared in the wake of these measures. https://www.foxnews.com/sports/jets-aaron-rodgers-takes-big-step-hopeful-return-achilles-injury Jets' Aaron Rodgers takes big step in hopeful return from Achilles injury The New York Jets opened the 21-day practice window for Aaron Rodgers on Wednesday, sparking hope the quarterback could return this season just mere months after tearing his Achilles. Jets head coach Robert Saleh told reporters that it doesn’t necessarily mean Rodgers is going to come back and play, but is rather a "progression in his rehab." "For Aaron, what he would be doing in practice is no different than what he’d be doing on the field with regard to certain drills in the individual – instead of throwing with staff members, he’s throwing with teammates," Saleh told reporters. "There’s no added risk to it. There’s certain things he’s been cleared for that we’re going to allow him to do." Saleh lauded Rodgers’ drive and motivation for pushing himself to get back to where he is and the want and need for him to be with his teammates. "He’s sacrificed so much already for the organization and himself and his teammates and he’s doing it again. I think it’s a testament to who he is as a human," Saleh added. Rodgers’ timeline is still really unclear. He tried to lay it out the best he could in his appearance on "The Pat McAfee Show" this week. "Once I'm healthy, then it's where we're at, are we alive, are we in it… It's health first, and are we alive for the playoffs second.". New York is 4-7 entering Week 13 and their playoff hopes are dwindling.

This is Garrison Hardie with your CrossPolitic Daily News Brief for Friday, December 1st, 2023. Pub Membership Plug: Public Houses, or Pubs, are not just places to drink beer, wine, cider or even something a little stronger. It is also a unique social centre, very often the focus of community life in villages, towns and cities throughout the length and breadth of the world. We here at CrossPolitic hope to emulate that for you and yours. That’s why you should grab yourself a pub membership at fightlaughfeast.com… we need you on this ride with us. So pull up a chair, grab a pint, and join us on this ride at fightlaughfeast.com - that’s fightlaughfeast.com. https://www.theblaze.com/news/damning-study-suggests-pandemic-lockdowns-accelerated-significant-memory-and-cognitive-decline-in-seniors Damning study suggests pandemic lockdowns accelerated 'significant' memory and cognitive decline in seniors The lockdowns and societal restrictions championed by teachers' unions and other leftists during the pandemic were not just ruinous for the mental health of children and teens. A new study out of the U.K. indicates pandemic restrictions also had a deleterious impact on the minds of the elderly. Dr. Anne Corbett of the University of Exeter Medical School and her team examined neuropsychology data from 3,142 individuals, all 50 years of age or over, who had been participating in a multi-decade dementia study in Britain. The researchers compared data on this cohort collected before the pandemic, early in the pandemic, then once more toward the tail end of the pandemic. The researchers observed "[s]ignificant worsening of executive function and working memory" in the first year of the pandemic across the whole cohort, the average age of which was 67.5. Working memory continued to worsen across the whole cohort in the second year of the pandemic. By the time restrictions had ultimately been eased, the damage had been done. According to the study, cognitive decline was significantly associated with reduced exercise and increased drinking across the whole cohort. Depression, another driving factor of cognitive decline, was notable amongst those who contracted COVID-19. Loneliness proved especially detrimental to those with mild cognitive impairment. "People aged 50 years and older in the UK had accelerated decline in executive function and working memory during the first year of the COVID-19 pandemic, during which the UK was subjected to three societal lockdowns for a total period of 6 months," said the study, published in the Lancet journal Healthy Longevity. The British government, which funded this study via the National Institute for Health and Care Research, not only limited the number of times citizens could exercise outside during the pandemic, but shuttered gyms, golf courses, sports courts, swimming pools, and indoor sports facilities. "The scale of change is also of note, with all groups—the whole cohort and the individual subgroups—showing more than a 50% greater decline in working memory and executive function and many effect sizes reaching a clinically significant threshold of greater than 0·3," said the researchers. The researchers further stressed that "[t]hese factors map closely to the population-wide changes in health and lifestyle seen during and after the lockdowns, raising the important question of the effect of the pandemic on cognitive health and risk across populations." https://www.foxnews.com/politics/appeals-court-reinstates-gag-order-trump-fraud-case Appeals court reinstates gag order in Trump fraud case A New York appeals court reinstated a gag order preventing former President Donald Trump from maligning court staffers on Thursday. New York Judge Arthur Engoron had initially issued the gag order in early October after Trump lashed out at one of his law clerks on social media. Trump is currently fighting accusations of business fraud leveled by New York Attorney General Letitia James. Appeals court Judge David Friedman had issued a stay on Engoron's gag order on Nov. 16, saying it potentially infringed on Trump's First Amendment rights. By that time, Engoron had already fined Trump $5,000 for violating the order on social media on Oct. 20, and did so again on Oct. 25 for another $10,000 before threatening imprisonment if further violations were committed. Trump took the stand to testify personally in early November. He repeatedly cast James’ yearslong investigation and lawsuit as a "disgrace" and an attack on his business and his family. Trump has denied any wrongdoing and insists his assets were actually undervalued. Trump has repeatedly said his financial statements had disclaimers requesting that the numbers be evaluated by the banks. Engoron ruled in September that both Trump and his company had committed fraud by deceiving banks, insurers and others by overvaluing his assets and exaggerating his net worth on paperwork used in making deals and securing financing. Trump has attacked Engoron and James — both Democrats — as politically biased "operatives." "They are defending the Worst and Least Respected Attorney General in the United States, Letitia James, who is a Worldwide disgrace, as is her illegal Witch Hunt against me. The Radical and Unprecedented actions of Judge Engoron will keep BUSINESSES and JOBS forever out of New York State," Trump wrote in a recent social media post. https://www.justfactsdaily.com/1-in-every-39-americans-will-die-of-a-drug-overdose-at-current-rate 1 in Every 39 Americans Will Die of a Drug Overdose at Current Rate Despite the passage of state and federal laws that were supposed to reduce fatal drug overdoses, the annual U.S. drug overdose death rate has quintupled over recent decades: Over the most current year of available data, more than 110,000 people in the U.S. died of drug overdoses, a rate of 33 per 100,000 population. In order to measure these deaths in clear, relevant terms, Just Facts enlisted the expertise of a licensed actuary and a Ph.D. mathematician to calculate, double-check, and triple-check the average lifetime odds of dying of a drug overdose. The shocking result of these calculations is that 1 in 39 people will have their lives cut short by drug overdoses if the rate of such deaths stays at the current level. Those odds will become far worse if the rising trend continues. The lifetime risks of tragic events are much more revealing than the raw numbers or annual rates commonly reported by government agencies and the media. This is partly because the U.S. is the third-most populous nation in the world, so tens, hundreds, or even thousands of events may amount to a very low risk. The other reason, which is less obvious, is explained by a 1987 Department of Justice report on the likelihood of being a crime victim: Annual victimization rates alone do not convey the full impact of crime as it affects people. No one would express his or her concern by saying, “I am terribly afraid of being mugged between January and December of this year.” People are worried about the possibility that at some time in their lives they will be robbed or raped or assaulted, or their houses will be burglarized. Each month, the CDC estimates drug overdose deaths based on data reported by the 50 states and the District of Columbia. The latest estimates, which include deaths up through June 2023, show that 111,877 people died of a drug overdose in the prior 12 months. To place such figures into the broader context of the U.S. population and people’s lifespans, Just Facts asked a licensed actuary to develop a method for calculating the average lifetime risk of death from various causes. The actuary used two separate methods, both of which yielded the same results. To further ensure accuracy, Just Facts had a Ph.D. mathematician check the formulas. Applying this methodology to the CDC’s latest estimates of overdose deaths, roughly 1 in every 39 people will die of drug overdose if the rate of such deaths stays at its current level. Beyond lifetime risk, another important measure of a mortal danger is the years of life that it robs from its victims. Because humans cannot prevent death but only delay it, there is a material difference between the tragic premature deaths of a 20-year-old in the prime of her life and a 90-year-old in poor health. Although some leading medical scholars ignored that vital fact during the Covid-19 pandemic, a 1983 CDC report about fatal accidents explains that the “the allocation of health resources must consider not only the number of deaths by cause but also by age.” The average age of people who die of drug overdoses is about 43 years, while the average U.S. lifespan is about 77 years. In contrast, the average age of people whose deaths involved Covid-19 is about 75 years. Yet, government officials locked down entire states for extended periods to prevent the spread of Covid, causing multitudes of collateral deaths. This likely included overdoses, which soared in the wake of these measures. https://www.foxnews.com/sports/jets-aaron-rodgers-takes-big-step-hopeful-return-achilles-injury Jets' Aaron Rodgers takes big step in hopeful return from Achilles injury The New York Jets opened the 21-day practice window for Aaron Rodgers on Wednesday, sparking hope the quarterback could return this season just mere months after tearing his Achilles. Jets head coach Robert Saleh told reporters that it doesn’t necessarily mean Rodgers is going to come back and play, but is rather a "progression in his rehab." "For Aaron, what he would be doing in practice is no different than what he’d be doing on the field with regard to certain drills in the individual – instead of throwing with staff members, he’s throwing with teammates," Saleh told reporters. "There’s no added risk to it. There’s certain things he’s been cleared for that we’re going to allow him to do." Saleh lauded Rodgers’ drive and motivation for pushing himself to get back to where he is and the want and need for him to be with his teammates. "He’s sacrificed so much already for the organization and himself and his teammates and he’s doing it again. I think it’s a testament to who he is as a human," Saleh added. Rodgers’ timeline is still really unclear. He tried to lay it out the best he could in his appearance on "The Pat McAfee Show" this week. "Once I'm healthy, then it's where we're at, are we alive, are we in it… It's health first, and are we alive for the playoffs second.". New York is 4-7 entering Week 13 and their playoff hopes are dwindling.

It's our Podcast series 7 finalé and our guest this week is a friend of ours Dr Rebecca Walker, she is an experienced GP with expertise in Menopause care, Migraine and Headache medicine, we talk all things migraine and Dr Becky de-bunks myths surrounding migraines. Find out how a migraine is diagnosed, and could your dizzy spells be vestibular migraine? Dr Becky tells us about the newest migraine medication and how migraines can develop or worsen in peri menopause. We ask if different HRT preparations affect different types of migraine. And do you think a migraine is always a headache? The answer may surprise you. Dr Walker works as an NHS GP in Devon and is part of a team of specialist GPs at the Exeter Headache Clinic, a National Health service for people with complex headache conditions. Becky is also a senior clinician with the National Migraine Centre, a specialist charity supporting people with migraine. As if that's not enough she is part of the team at Myla Health who provide individualised private menopause support. Dr Walker enjoys sharing her learning and teaches on Headache Medicine and Menopause to GPs, and to students at Exeter Medical School. She has also written articles on menopause and migraine. We've been fortunate enough to meet with Becky several times in the past few months since she moved to Devon, and what a pleasure it has been so we asked her to join us on the podcast to talk about migraines and hormones, particularly in menopause. You can watch the full interview on our YouTube channel: https://www.youtube.com/channel/UCFgmHLcdx28eco-XlkWYwUA   Have you heard of the Malaya Lola's? These were a group of teens and children snatched from their homes and imprisoned and raped during WW2. These girls were called ‘comfort women' and were abused by Japanese soldiers in the Japanese Imperial Army. Jinty uncovers the Filipino women's story.   Foodie - as we conclude our theme for this month we have a traditional shortbread recipe from Sainsbury's. Click the link for the full recipe: https://www.sainsburysmagazine.co.uk/recipes/baking/classic-shortbread Find out how Lou got it so very wrong!   Book Collective we announce our book for series 8 and it's from the wonderful Caro Giles: Twelve Moons. A Year Under A Shared Sky published by Harper Collins.   There's a new WI that you can get involved in, there's an inspirational quote from Jinty and have you ever experienced an eargasms? It's another episode brimming with chat, your comments, and all the usual shenanigans. So, settle in for this hour(ish) podcast full of meaningful chat.   Our campaign for a Menopause Clinic in Devon is moving closer but we still need signatures on our petition: https://www.change.org/p/wheresmyclinic Or to send your testimonials please email us: menopauseclinicdc@gmail.com And finally, if you would like the templates to send to your MP or CCG please visit our website: https://menopauseclinicfordevon.co.uk   Dr Rebecca Walker: I: dr_rebeccawalker W: https://www.nationalmigrainecentre.org.uk/ --- Send in a voice message: https://podcasters.spotify.com/pod/show/womenkindcollectivepodcast/message

A new wave of so-called anti-obesity drugs are promising a full-proof way of losing weight. And their popularity is growing. But how safe are they? Guests: Prof Alex Miras Professor and Consultant in Endocrinology, Ulster University Dr Bharat Pankhania Senior Clinical Lecturer at University of Exeter Medical School. Sarah Dosanjh Psychotherapist who studies binge eating Rosemary Conley Health and Fitness expert Roundtable is a discussion programme with an edge. Broadcast out of London and presented by Philip Hampsheir, it's about bringing people to the table, listening to every opinion, and analysing every point of view. From fierce debate to reflective thinking, Roundtable discussions offer a different perspective on the issues that matter to you. Watch it every weekday at 15:00 GMT on TRT World.

Są ludzie, którzy nie potrafią wolicjonalnie kreować (albo robią to rzadko) obrazów w swojej wyobraźni. Takie zjawisko nazywa się afantazją wizualną. To pojęcie wprowadził w 2015 r. do dyskursu naukowego prof. Adam Zeman z University of Exeter Medical School. Więcej o afantazji wizualnej, metodach badania działania naszej wyobraźni oraz jak zróżnicowane może być postrzeganie świata i wspomnień w rozmowie z Jerzym Jeziorskim, absolwentem kierunku kognitywistyka na Uniwersytecie Jagiellońskim. Zaprasza Paweł Chlastacz

We've talked about the subject of behavior change on the Wellness Paradox many times before, but this time of year it is particularly important given the New Year's resolution crowd rushing to find fitness professionals to help them achieve their goals.  Our guest in episode 88, Natalie Grinvalds, knows this topic well as her area of both research and practice focuses on physical activity and health behavior. In this episode we'll dive into a discussion around how to collaborate with clients to ensure the behavior changes they're looking to make are sustainable in the long-term. Natalie does a great job of providing practical, evidence-based, suggestions that you can implement with your clients today to ensure those behaviors they're so motivated to implement now, stick for longer than just the next couple of weeks. Have your notebook handy for this conversation, as Natalie provides a master class on behavior change for fitness professionals.Show Notes Page: https://www.wellnessparadoxpod.com/podcast/episode/88Our Guest: Dr. Natalie Grinvalds, Ph.D. Natalie Grinvalds is currently a health behaviour change scientist and physical activity researcher. She is working in a knowledge transfer partnership with University of Exeter Medical School and Health and Care Innovations to embed behaviour science into their app designed to help people manage living with multiple long-term conditions.Alongside this she is a fitness professional, freelance assessor (for personal training, gym instruction and exercise referral qualifications) and visiting lecturer.She is passionate about applying behaviour science, sport psychology, sport science and love for music in her indoor cycling classes and fitness instruction and loves helping people to reframe their mindset about exercise, nutrition and what it means to live a healthy life. She currently teaches fitness classes at Exeter Leisure, including the UK's first Passivhaus Leisure Centre and University of Exeter Sport and previously at University of Sheffield's, Sport Sheffield.Follow us on social at the links below: https://www.facebook.com/wellnessparadox https://www.instagram.com/wellnessparadox/ https://www.linkedin.com/company/wellness-paradox-podcast https://twitter.com/WellnessParadox

We recorded this episode live at the 2022 Canadian Surgical Forum in Toronto, Canada. We managed to catch up with the globetrotting colorectal surgeon, Dr. Neil Smart, right after his in-depth session at CSF on parastomal hernias. Dr. Smart is based out of Exeter, UK and is the current Editor-in-Chief of the journal Colorectal Disease. In this masterclass episode we delved deep into the management of parastomal hernias, covering stoma formation itself to the surgical management of this complex disease. Be sure to check out the links to Dr. Smart's study in the show notes. Neil Smart Twitter handle: @Neil_J_Smart Links: 1. Cohort study to Investigate the prevention of Parastomal Hernia (CIPHER) study: Cohort study to Investigate the prevention of Parastomal Hernia (CIPHER) 2. Twitter link to CIPHER study: https://twitter.com/TheCIPHERStudy?s=20&t=ECwhYqAUrf43WN9h0SuFzw 3. PROPHER study: https://www.escp.eu.com/research/cohort-studies/2019-patient-reported-outcomes-after-parastomal-hernia-treatment 4. Twitter link to PROPHER study: https://www.escp.eu.com/research/cohort-studies/2019-patient-reported-outcomes-after-parastomal-hernia-treatment Bio (from https://www.europeanherniasociety.eu/new-ehs-wing-members): Neil Smart is an academic surgeon at the Royal Devon & Exeter hospital & Honorary Associate Professor at the University of Exeter Medical School. His clinical practice includes subspecialty interests in rectal cancer, hernia prophylaxis, incisional hernia repair / complex abdominal wall reconstruction and parastomal & perineal hernias. Neil has been involved in hernia research for over 15 years, leading a range of study designs from clinical to translational studies, and participating in RCTs and qualitative research. Most notably: • generated over £1.3 million total in research funds directed primarily at hernia research. • Chief Investigator of the NIHR funded CIPHER study on parastomal hernia. • translational work into mesh characteristics. • co-applicant of research onto parastomal hernia repair, incisional hernia outcomes reporting and the impact of Covid on hernia surgery. Neil has published extensively in the field of hernia surgery and mesh, including 3 hernia related guidelines for EHS & ACPGBI on parastomal & perineal hernias. He has been a specialty advisor to NICE for mesh & stomas since 2018. Neil is Editor in Chief of the journal Colorectal Disease and has provided peer review for over 20 other journals. He has provided peer review for grant awarding bodies including NIHR / MRC / RCUK / AMRC.

An interview with Dr Phil Evans, an academic GP, associate professor at the University of Exeter Medical School, National Institute Health Research (NIHR) Primary Care lead and recently appointed as a deputy medical director of NIHR Clinical Research Network.    A wide ranging conversation including the benefits of continuity of care in General Practice. To find out more about the benefits of continuity for patients and doctors see the St Leonard's Research Practice website https://www.continuitycounts.com/patient-information   Host: Dr Daniel Butler @danielnbutler      

In this episode we talk to Dr Sarah Price who is a research fellow at the University of Exeter Medical School. Paper: Intra-abdominal cancer risk with abdominal pain: a prospective cohort primary care study https://doi.org/10.3399/BJGP.2021.0552 (https://doi.org/10.3399/BJGP.2021.0552) Abdominal pain is a non-specific symptom, which may portend serious disease, including intra-abdominal cancers. There is no unified pathway for investigation. This paper reports the 1-year cumulative incidence risk of intra-abdominal cancer with or without concurrent clinical features for men and women aged 40–59, 60–69 and ≥70 years. Results show that patient demographics and type of concurrent feature effects the cancer risk. These results will inform appropriate testing strategies and specialist referral.

The World Health Organization says nearly 15 million people died in the first two years of the pandemic, mostly as a result of the virus itself - but also because people couldn't get proper treatment since hospitals were overwhelmed. The WHO says it's a wake up call for countries to invest in data and their healthcare systems to make them resilient to crises. So, what lessons should be learned? Join host Adrian Finighan. Guests: Bharat Pankhania - Senior Clinical Lecturer at the University of Exeter Medical School. Azeddine Ibrahimi - Professor of Medical Biotechnology at the Rabat Medical School. T. Sundararaman - Health Systems Expert.  

2021 saw the global rollout of vaccines against COVID-19. They have had a significant effect in reducing infection, illness and deaths although the Omicron variant may reduce their efficacy. New anti-viral treatments are also being approved and will be distributed at the start of 2022. But not everyone in the world has had access to vaccines with a significant shortage of supply in the developing world. Scientists say for as long as that is the case, the emergence of new variants like Omicron will remain a serious threat. Doctor Bharat Pankhania is a senior clinical lecturer at the University of Exeter Medical School. He told us more about how developed countries have failed to deliver their promises of immunising the rest of the world. #Vaccine #CovidVariants #CovidTreatment

Can we keep our schools open in January or does the surge of Omicron signal more disruption for children and their families? In this episode, ITV News Presenter and Reporter Faye Barker talks to Dr David Strain, a senior clinical lecturer at the University of Exeter Medical School, to find out if we can send our children back to school with confidence.He tells us what we need to know, discusses how Omicron may be more dangerous for children and how delaying the start of the new school term in 2022 may benefit us all.Stay up to date with the latest Coronavirus news, information and advice at itv.com/news

In this podcast, Jo Raven, Senior Manager of Research and Engagements at FAIRR is joined by Professor Will Gaze, of the University of Exeter Medical School and David Tsoupros, Vice President of Senior Research Analyst at AllianceBernstein asset management, to discuss what the UN has called the “silent pandemic” within our food system that's threatening food security, the environment, industries from farming to pharmaceuticals, and global public health.Antimicrobial resistance, or AMR, is the emergence of superbugs that are resistant to antibiotics. It's currently responsible for around 700 thousand deaths a year and the World Bank estimates it could wipe 11% off the world's GDP by 2050.Animal farming is a key contributor to this crisis, given that an estimated 70% of all antimicrobial use happens within animal agriculture. Without tackling the widespread overuse, and misuse, of antibiotics in livestock, it's likely AMR could become the next global pandemic. In the first of a two-part series on AMR, this podcast looks looking at the environmental impacts of this crisis and what investors are doing to address this risk. FAIRR's latest report, Feeding Resistance: Antimicrobial stewardship in the animal health industry, is available on their website and explores the role of animal pharmaceuticals in driving AMR, and how investors can engage the sector to drive better stewardship. See acast.com/privacy for privacy and opt-out information.

How much is the summer festival season to blame for the current rise in cases? What can be done to make crowded events safer? And are young people getting together en masse really aware of the risks of Covid and long covid?Faye Barker puts those questions to Dr David Strain, an acute physician and lecturer at the University of Exeter Medical School, who has been playing a leading role in the British Medical Association's Covid response, in particular Long Covid with the NHS taskforce.We also hear what the organiser of the Leeds Festival told ITV News in defence of holding mass gatherings in a pandemic, plus from 16-year-old Tilly from east Devon, who was among several thousand festivalgoers to catch Covid at this summer's Boardmasters festival in Cornwall. She describes her Covid-era festival experience, when it became clear that the soar throat she returned with hadn't come from five days of screaming and shouting, and why she'd still do it all over again.

The disparity in access to COVID vaccines is deepening as health officials begin recommending booster shots for fully vaccinated people. The World Health Organization says giving booster shots to people who are already fully vaccinated is like handing out extra life jackets to people already wearing one. Guests: Dr Annelies Wilder Smith Professor of Emerging Infectious Diseases at the London School of Hygiene and Tropical Medicine and Consultant to the World Health Organization Dr Archie Clements Professor of Health Sciences at Curtin University and Director of the Research School of Population Health at the Australian National University Dr Bharat Pankhania Senior Clinical Lecturer at University of Exeter Medical School

Pessimism of the Intellect, Optimism of the Will Bill Gates Partnered Chinese To Conduct Gain-Of-Function Research Delta Variant Far Less Deadly than Previous Variants, According to TrialSite Analysis CDC and Media Say 61% of Americans are Vaxxed, but Data Shows it is 32% What Will Segregated Society Look Like for the Unvaxxed? IPCC climate report: Profound changes are underway in Earth's oceans and ice – a lead author explains what the warnings mean Ohio judge orders man to get a COVID-19 vaccine as part of his sentence Youth, the pandemic and a global mental health crisis A Different World Order   Today's Videos 1.  Vaccine Stories  2. A MESSAGE TO THE EDINBURG CISD SCHOOL BOARD 3.AGUIRRE HAWAII COVID WHISTLEBLOWER 4. ARE PEOPLE DYING MISDIAGNOSED? DR. BRYAN ARDIS, DR. REINER FUELLMICH AND DR. WOLFGANG WODARG   Strawberries improve cognition in a randomized, double-blind, placebo-controlled trial of older adults Tufts University, August 8, 2021 According to news originating from Boston, Massachusetts, research stated, “Functional changes in the brain during ageing can alter learning and memory, gait and balance - in some cases leading to early cognitive decline, disability or injurious falls among older adults. Dietary interventions with strawberry (SB) have been associated with improvements in neuronal, psychomotor and cognitive functions in rodent models of ageing.” Our news journalists obtained a quote from the research from Tufts University, “We hypothesised that dietary supplementation with SB would improve mobility and cognition among older adults. In this study, twenty-two men and fifteen women, between the ages of 60 and 75 years, were recruited into a randomised, double-blind, placebo-controlled trial in which they consumed either freeze-dried SB (24 g/d, equivalent to two cups of fresh SB) or a SB placebo for 90 d. Participants completed a battery of balance, gait and cognitive tests at baseline and again at 45 and 90 d of intervention. Significant supplement group by study visit interactions were observed on tests of learning and memory. Participants in the SB group showed significantly shorter latencies in a virtual spatial navigation task (P = 0.020,.p2 = 0.106) and increased word recognition in the California Verbal Learning test (P = 0.014,.p2 = 0.159) across study visits relative to controls. However, no improvement in gait or balance was observed.” According to the news editors, the research concluded: “These findings show that the addition of SB to the diets of healthy, older adults can improve some aspects of cognition, but not gait or balance, although more studies with a larger sample size and longer follow-up are needed to confirm this finding.” This research has been peer-reviewed.   Growing evidence of vitamin K benefits for heart health Edith Cowan University (Australia), August 10, 2021 New Edith Cowan University (ECU) research has found that people who eat a diet rich in vitamin K have up to a 34 percent lower risk of atherosclerosis-related cardiovascular disease (conditions affecting the heart or blood vessels). Researchers examined data from more than 50,000 people taking part in the Danish Diet, Cancer, and Health study over a 23-year period. They investigated whether people who ate more foods containing vitamin K had a lower risk of cardiovascular disease related to atherosclerosis (plaque build-up in the arteries). There are two types of vitamin K found in foods we eat: vitamin K1 comes primarily from green leafy vegetables and vegetable oils while vitamin K2 is found in meat, eggs and fermented foods such as cheese. The study found that people with the highest intakes of vitamin K1 were 21 percent less likely to be hospitalized with cardiovascular disease related to atherosclerosis. For vitamin K2, the risk of being hospitalized was 14 percent lower. This lower risk was seen for all types of heart disease related to atherosclerosis, particularly for peripheral artery disease at 34 percent. ECU researcher and senior author on the study Dr. Nicola Bondonno said the findings suggest that consuming more vitamin K may be important for protection against atherosclerosis and subsequent cardiovascular disease. "Current dietary guidelines for the consumption of vitamin K are generally only based on the amount of vitamin K1 a person should consume to ensure that their blood can coagulate," she said. "However, there is growing evidence that intakes of vitamin K above the current guidelines can afford further protection against the development of other diseases, such as atherosclerosis. "Although more research is needed to fully understand the process, we believe that vitamin K works by protecting against the calcium build-up in the major arteries of the body leading to vascular calcification." University of Western Australia researcher Dr. Jamie Bellinge, the first author on the study, said the role of vitamin K in cardiovascular health and particularly in vascular calcification is an area of research offering promising hope for the future. "Cardiovascular disease remains a leading cause of death in Australia and there's still a limited understanding of the importance of different vitamins found in foodand their effect on heart attacks, strokes and peripheral artery disease," Dr. Bellinge said. "These findings shed light on the potentially important effect that vitamin K has on the killer disease and reinforces the importance of a healthy diet in preventing it." Dr. Bondonno said that while databases on the vitamin K1 content of foods are very comprehensive, there is currently much less data on the vitamin K2 content of foods. Furthermore, there are 10 forms of vitamin K2 found in our diet and each of these may be absorbed and act differently within our bodies. "The next phase of the research will involve developing and improving databases on the vitamin K2 content of foods. "More research into the different dietary sources and effects of different types of vitamin K2 is a priority," Dr. Bondonno said. Additionally, there is a need for an Australian database on the vitamin K content of Australian foods (e.g. vegemite and kangaroo). To address this need, Dr. Marc Sim, a collaborator on the study, has just finished developing an Australian database on the vitamin K content of foods which will be published soon. The paper "Vitamin K intake and atherosclerotic cardiovascular disease in the Danish Diet Cancer and Health Study' was published in the Journal of the American Heart Association. High BMI causes depression, both physical and social factors play a role University of Exeter (UK), August 9, 2021 A large-scale study provides further evidence that being overweight causes depression and lowers wellbeing and indicates both social and physical factors may play a role in the effect. With one in four adults estimated to be obese in the UK, and growing numbers of children affected, obesity is a global health challenge. While the dangers of being obese on physical health is well known, researchers are now discovering that being overweight can also have a significant impact on mental health.  The new study, published in Human Molecular Genetics, sought to investigate why a body of evidence now indicates that higher BMI causes depression. The team used genetic analysis, known as Mendelian Randomisation, to examine whether the causal link is the result of psychosocial pathways, such as societal influences and social stigma, or physical pathways, such as metabolic conditions linked to higher BMI. Such conditions include high blood pressure, type 2 diabetes and cardiovascular disease. In research led by the University of Exeter and funded by the Academy of Medical Sciences, the team examined genetic data from more than 145,000 participants from the UK Biobank with detailed mental health data available. In a multifaceted study, the researchers analyzed genetic variants linked to higher BMI, as well as outcomes from a clinically-relevant mental health questionnaire designed to assess levels of depression, anxiety and wellbeing. To examine which pathways may be active in causing depression in people with higher BMI, the team also interrogated two sets of previously discovered genetic variants. One set of genes makes people fatter, yet metabolically healthier, meaning they were less likely to develop conditions linked to higher BMI, such as high blood pressure and type 2 diabetes. The second set of genes analyzed make people fatter and metabolically unhealthy, or more prone to such conditions. The team found little difference between the two sets of genetic variants, indicating that both physical and social factors play a role in higher rates of depression and poorer wellbeing. Lead author Jess O'Loughlin, at the University of Exeter Medical School, said: "Obesity and depression are both major global health challenges, and our study provides the most robust evidence to date that higher BMI causes depression. Understanding whether physical or social factors are responsible for this relationship can help inform effective strategies to improve mental health and wellbeing. Our research suggests that being fatter leads to a higher risk of depression, regardless of the role of metabolic health. This suggests that both physical health and social factors, such as social stigma, both play a role in the relationship between obesity and depression." Lead author Dr. Francesco Casanova, of the University of Exeter Medical School, said, "This is a robust study, made possible by the quality of UK Biobank data. Our research adds to a body of evidence that being overweight causes depression. Finding ways to support people to lose weight could benefit their mental health as well as their physical health." The study, titled "Higher adiposity and mental health: causal inference using Mendelian Randomisation," is published in Human Molecular Genetics.   Protective effects of saffron compound against amyloid beta-induced neurotoxicity Guangdong Medical University (China), August 4, 2021 According to news reporting from Dongguan, People's Republic of China, research stated, “Alzheimer's disease (AD) is a most common neurodegenerative disorder worldwide. Because of its complex pathogenesis, the prevention and therapies of AD still are a severe challenge.” The news correspondents obtained a quote from the research from Guangdong Medical University, “Evidence suggested that crocin, the major component of saffron, exhibited neuroprotective effects in AD. As such, in this study, N2a/APP695swe cells were enrolled to investigate the effects of crocin on endogenous A beta-induced neurotoxicity. Crocin (100 and 200 mu M) could ameliorate cytotoxicity according to CCK-8 assay and reduce apoptosis in line with Hoechst 33,342 staining and Annexin V-FITC/PI double staining in N2a/APP695swe cells. Reduced ROS generation and elevated MMP were found in N2a/APP695swe cells treated with crocin (100 and 200 mu M). Additionally, crocin at concentrations of 100 and 200 mu M inhibited the release of cytochrome and attenuated caspases-3 activity in N2a/APP695swe cells. Furthermore, succinylation, crotonylation, 2-hydroxyisobutyrylation, malonylation, and phosphorylation were significantly reduced, while a slight increase of acetylation was found in 100-mu M crocin treated N2a/APP695swe cells.” According to the news reporters, the research concluded: “Taken together, crocin may be a promising natural product candidate for the effective cure of AD.” This research has been peer-reviewed.   Microbes have potential to reverse aging in the brain University College Cork (Ireland), August 10, 2021 Microbiome Ireland, a world leading SFI Research Centre, have found that aging-associated changes in the immune system of old mice were reversed by the transfer of gut microbiota from the young mice. The researchers saw improved behavior of older mice in several cognitive tests for learning, memory and anxiety. Credit: Clare Keogh Research from APC Microbiome Ireland (APC) at University College Cork (UCC) published today in the leading international scientific journal Nature Agingintroduces a novel approach to reverse aspects of aging-related deterioration in the brain and cognitive function via the microbes in the gut. As our population ages one of the key global challenges is to develop strategies to maintain healthy brain function. This ground-breaking  research opens up a potentially new therapeutic avenues  in the form of microbial-based interventions to slow down brain aging and associated cognitive problems.  The work was carried out by researchers in the Brain-Gut-Microbiota lab in APC led by Prof John F. Cryan, Vice President for Research & Innovation, University College Cork as well as a Principal Investigator at APC Microbiome Ireland  an SFI Research Centre,  based in in University College Cork and Teagasc Moorepark. There is a growing appreciation of the importance of the microbes in the gut on all aspects of physiology and medicine. In this latest mouse study the authors show that by transplanting microbes from young into old animals they could rejuvenate aspects of brain and immune function. Prof John F. Cryan, says "Previous research published by the APC and other groups internationally has shown that the  gut microbiome plays a key role in aging and the aging process. This new research is a potential game changer , as we have established that the microbiome can be harnessed to reverse age-related brain deterioration. We also see evidence of improved learning ability and cognitive function". Although very exciting Cryan cautions that "it is still early days and much more work is needed to see how these findings could be translated in humans".   APC Director Prof Paul Ross stated that "This research of Prof. Cryan and colleagues further demonstrates the importance of the gut microbiome in many aspects of health, and particularly across across the brain/gut axis where brain functioning can be positively influenced. The study opens up possibilities in the future to modulate gut microbiota as a therapeutic target to influence brain health" The study was led by co-first authors Dr. Marcus Boehme along with Ph.D. students Katherine E. Guzzetta, and Thomaz Bastiaansen. Even quick meditation aids cognitive skills Yale University & Swarthmore College, August 7, 2018  College students who listen to a 10-minute meditation tape complete simple cognitive tasks more quickly and accurately than peers who listen to a "control" recording on a generic subject, researchers at Yale University and Swarthmore College report. The study, published in the journal Frontiers of Neuroscience, shows even people who have never meditated before can benefit from even a short meditation practice. "We have known for awhile that people who practice meditation for a few weeks or months tend to perform better on cognitive tests, but now we know you don't have to spend weeks practicing to see improvement," said Yale's Hedy Kober, associate professor of psychiatry and psychology and senior author of the study. The research team headed by Kober and Catherine Norris at Swarthmore randomly divided college students into two groups. One group listened to a 10-minute recording on meditation prior to performing cognitive tests and the second group listened to a similarly produced tape about sequoia trees. Both groups were then given simple tasks designed to measure cognitive dexterity. Those who listened to the meditation recording performed significantly better, across two studies. There was one exception, however. Those who scored highest in measurements of neuroticism—"I worry all the time"—did not benefit from listening to the meditation tape. "We don't know if longer meditation sessions, or multiple sessions, would improve their cognitive scores, and we look forward to testing that in future studies," Kober said.   Physical activity protects children from the adverse effects of digital media on their weight later in adolescence University of Helsinki (Finland), August 9, 2021   Children's heavy digital media use is associated with a risk of being overweight later in adolescence. Physical activity protects children from the adverse effects of digital media on their weight later in adolescence. A recently completed study shows that six hours of leisure-time physical activity per week at the age of 11 reduces the risk of being overweight at 14 years of age associated with heavy use of digital media. Obesity in children and adolescents is one of the most significant health-related challenges globally. A study carried out by the Folkhälsan Research Center and the University of Helsinki investigated whether a link exists between the digital media use of Finnish school-age children and the risk of being overweight later in adolescence. In addition, the study looked into whether children's physical activity has an effect on this potential link. The results were published in the Journal of Physical Activity and Health. More than six hours of physical activity per week appears to reverse adverse effects of screen time The study involved 4,661 children from the Finnish Health in Teens (Fin-HIT) study. The participating children reported how much time they spent on sedentary digital media use and physical activity outside school hours. The study demonstrated that heavy use of digital media at 11 years of age was associated with a heightened risk of being overweight at 14 years of age in children who reported engaging in under six hours per week of physical activity in their leisure time. In children who reported being physically active for six or more hours per week, such a link was not observed. The study also took into account other factors potentially impacting obesity, such as childhood eating habits and the amount of sleep, as well as the amount of digital media use and physical activity in adolescence. In spite of the confounding factors, the protective role of childhood physical activity in the connection between digital media use in childhood and being overweight later in life was successfully confirmed. "The effect of physical activity on the association between digital media use and being overweight has not been extensively investigated in follow-up studies so far," says Postdoctoral Researcher Elina Engberg. Further research is needed to determine in more detail how much sedentary digital media use increases the risk of being overweight, and how much physical activity is needed, and at what intensity, to ward off such a risk. In this study, the amount of physical activity and use of digital media was reported by the children themselves, and the level of their activity was not surveyed, so there is a need for further studies. "A good rule of thumb is to adhere to the physical activity guidelines for children and adolescents, according to which school-aged children and adolescents should be physically active in a versatile, brisk and strenuous manner for at least 60 minutes a day in a way that suits the individual, considering their age," says Engberg. In addition, excessive and extended sedentary activity should be avoided.

For many Long COVID patients the debilitating long-term symptoms they experience emerged after what, at first, appeared to be a mild COVID-19 infection. Professor David Strain, Senior Clinical Lecturer at University of Exeter Medical School and Honorary Consultant in Medicine, speaks to Patrick about the patterns he saw emerge while working on the frontline of the pandemic. From the first time David attended a meeting about COVID-19, at a 3am webinar broadcast from China, to working with Sano to help identify the genetic markers of Long COVID, they discuss the still emerging impact of the condition, from the first use of the term 'Long COVID' in May 2020, up until today.

For many Long COVID patients the debilitating long-term symptoms they experience emerged after what, at first, appeared to be a mild COVID-19 infection. Professor David Strain, Senior Clinical Lecturer at University of Exeter Medical School and Honorary Consultant in Medicine, speaks to Patrick about the patterns he saw emerge while working on the frontline of the pandemic. From the first time David attended a meeting about COVID-19, at a 3am webinar broadcast from China, to working with Sano to help identify the genetic markers of Long COVID, they discuss the still emerging impact of the condition, from the first use of the term 'Long COVID' in May 2020, up until today.

On this episode of the Ikigai Podcast, Dr. Holly Sugg, a Lecturer in Education and Research for the Academy of Nursing at the University of Exeter Medical School, talks to Nick about Morita therapy. How it is different from the western approach and its similarities to the ikigai concept.Holly co-authored a paper titled “What is Morita Therapy? The Nature, Origins, and Cross‐Cultural Application of a Unique Japanese Psychotherapy”.

Peter talks us through managing patients that display counter intuitive behaviours. How can we look at causes but, more importantly, how can we safely manage patients who are violent, want to run away or who do not look at the responder as help.     Top tips    1) Always have and practice an exit strategy, identify who can help and where that person needs to be    2) Can you upskill to recognise a person who is vulnerable    3) Can you ask the right questions?    4) Listen well, this is an art but is fundamental in helping people with counterintuitive behavior    Biography   Dr Peter Aitken MRCGP FRCPsych is Director of Research & Development and executive lead for suicide prevention at Devon Partnership NHS Trust and Honorary Associate Professor, University of Exeter Medical School.   He is chair of the Medical Committee at the RNLl, mental health adviser to the National Association of Primary Care, trustee at the Lions Barber Collective, and member of the steering group for Zero Suicide Alliance. He is a past chair of the Faculty of Liaison Psychiatry at the Royal College of Psychiatrists and Psychiatrist of the Year in 2016 for his work with NHS England leading the design and delivery of Core24 Liaison Psychiatry Services for all English Hospitals with an Emergency Department.   As an executive and clinical leader, he trained in quality improvement with the US Institute for Health Improvement Patient Safety Program and the NHS program for Advanced Improvement in Quality & Safety. He has published in suicide prevention and has an experience of drawing learning from the national confidential inquiry into effective action for change in services and hard to reach communities.  

In celebration of Rare Disease Day, we hear from a panel of five inspiring guests - all who share their unique perspectives about one particular rare condition called Congenital Hyperinsulinism. Join us to hear these valuable insights from Julie Raskin – Co-Founder and Executive Director, Congenital Hyperinsulinism International (CHI), New Jersey, and mom to Ben who has congenital hyperinsulinism; Sheila Bose – Vice President of the Board of Directors for CHI and parent to 3 children born with congenital hyperinsulinism; Dr Sarah Flanagan - Associate Professor in Genomic Medicine at the University of Exeter Medical School; Dr. Diva De León-Crutchlow - Chief of Endocrinology and Diabetes and Director of the Congenital Hyperinsulinism Center at Children's Hospital of Philadelphia; and Dr. Paul Thornton – Medical Director of the Endocrine and Diabetes Program at Cook Children’s Medical Center, Texas.

Governments and corporations around the world are planning to give so-called vaccine passports to people inoculated against COVID-19. These aim to revive the travel industry, and could eventually be crucial to reopening the rest of the global economy. But as Paolo Montecillo reports, policymakers will have to make sure the schemes are implemented in such a way that no one is left behind. For more, we spoke to Doctor Bharat Pankhania in the British city of Bath. He's a senior clinical lecturer at the University of Exeter Medical School, with extensive experience in advising on national communicable disease control plans. #VaccinePassport #Denmark #BusinessTravellers

Mark Hannaford is an honorary associate professor awarded for his work in Extreme Medicine by the University of Exeter Medical School and is the founding director of World Extreme Medicine, an International Fellow of the prestigious New York-based Explorers Club, and Fellow of both the Royal Geographical Society and the Royal Society of Arts. He founded an Msc Program in Extreme Medicine at Exeter University. The UK.

Gary takes on the real issues that the mainstream media is afraid to tackle. Tune in to find out the latest about health news, healing, politics, and the economy. Meta-analysis finds dietary supplements improve sleep quality Hong Kong Polytechnic University, January 27 2021.    A systematic review and meta-analysis published on January 13, 2021 in Postgraduate Medical Journal found benefits for supplemental vitamin D, melatonin and amino acids in improving the quality of sleep among men and women.  The meta-analysis included 15 randomized, controlled trials that examined the association between subjective sleep quality as assessed by the Pittsburgh Sleep Quality Index (PSQI) and supplementation with amino acids, the hormone melatonin, omega 3 fatty acids and vitamin D. Pooled data for the two studies involving amino acid supplements, seven studies involving melatonin, and four studies involving vitamin D each showed significant differences between supplemented and control groups, with more favorable PSQI scores occurring among those who received the supplements. The two studies that evaluated omega 3 did not reveal significant differences between the treatment and control groups. Two reviewed trials that were not eligible for inclusion in the meta-analysis added evidence to the benefit of melatonin in sleep quality. Other non-included trials found a benefit for nitrate-containing beetroot juice, resveratrol and zinc supplements. Co-supplementation with melatonin, magnesium and zinc was also associated with a significant benefit in comparison with a placebo.  “Although we found a significant improvement in sleep quality by dietary supplementation, randomized, controlled trials with longer duration and larger sample size should be conducted to verify our findings,” noted authors Vicky Chan and Kenneth Lo of The Hong Kong Polytechnic University. “Furthermore, dose–response effect of different supplements on sleep quality has not yet been evaluated.” “Amino acids, vitamin D and melatonin supplements were significantly beneficial to improve sleep quality,” they concluded. “Further research on the effect of magnesium, zinc, resveratrol and nitrate supplementation on improving sleep quality is required.”     Green coffee extract and silymarin protect against carbon tetrachloride-induced liver toxicity University of Tabuk (Saudi Arabia), January 26, 2021   According to news originating from the University of Tabuk research stated, “During the last few decades, patients worldwide have been interested in using alternative medicine in treating diseases to avoid the increased side effects of chemical medications. Green coffee is unroasted coffee seeds that have higher amounts of chlorogenic acid compared to roasted coffee.” Our news journalists obtained a quote from the research from University of Tabuk: “Green coffee was successfully used to protect against obesity, Alzheimer disease, high blood pressure and bacterial infection. This study aimed to investigate the probable protective activity of the green coffee methanolic extract, silymarin and their combination on CCl4-induced liver toxicity in male rats. Thirty Sprague - Dawley male albino rats were divided into 5 groups; control negative (G1) just got the vehicle (olive oil) and the other four groups received CCl4 dissolved in olive oil through an intraperitoneal injection and were divided into untreated control positive group (G2), the third group (G3) was treated with green coffee methanolic extract, the fourth group (G4) was treated with silymarin, and the fifth group (G5) was treated with a combination of green coffee methanolic extract and silymarin. In the positive control group treated with CCl4 (G2), the CCl4-induced toxicity increased lipid peroxidation, IL-6, kidney function parameters, liver function enzymes, total cholesterol, triglycerides and low-density lipoproteins, and decreased irisin, antioxidants, CYP450 and high-density lipoprotein levels. Hepatic tissues were also injured. However, treating the injured rats in G3, G4 and G5 significantly improved the altered parameters and hepatic tissues.” According to the news reporters, the research concluded: “Green coffee methanolic extract, silymarin, and their combination succeeded in protecting the male rats against CCl4 hepatotoxicity due to their antioxidant activity. Effect of green coffee methanolic extract mixed with silymarin in G5 was more efficient than that of green coffee methanolic extract in G3 or silymarin in G4.”     Vitamin D status and outcomes for hospitalised older patients with COVID-19 NHS Foundation Trust and University of Cyprus, January 21, 2021   Purpose Older adults are more likely to be vitamin D deficient. The aim of the study was to determine whether these patients have worse outcomes with COVID-19. Methods We conducted a prospective cohort study between 1 March and 30 April 2020 to assess the importance of vitamin D deficiency in older patients with COVID-19. The cohort consisted of patients aged ≥65 years presenting with symptoms consistent with COVID-19 (n=105). All patients were tested for serum 25-hydroxyvitamin D (25(OH)D) levels during acute illness. Diagnosis of COVID-19 was confirmed via viral reverse transcriptase PCR swab or supporting radiological evidence. COVID-19-positive arm (n=70) was sub-divided into vitamin D-deficient (≤30 nmol/L) (n=39) and -replete groups (n=35). Subgroups were assessed for disease severity using biochemical, radiological and clinical markers. Primary outcome was in-hospital mortality. Secondary outcomes were laboratory features of cytokine storm, thoracic imaging changes and requirement of non-invasive ventilation (NIV). Results COVID-19-positive arm demonstrated lower median serum 25(OH)D level of 27 nmol/L (IQR=20–47 nmol/L) compared with COVID-19-negative arm, with median level of 52 nmol/L (IQR=31.5–71.5 nmol/L) (p value=0.0008). Among patients with vitamin D deficiency, there was higher peak D-dimer level (1914.00 μgFEU/L vs 1268.00 μgFEU/L) (p=0.034) and higher incidence of NIV support and high dependency unit admission (30.77% vs 9.68%) (p=0.042). No increased mortality was observed between groups. Conclusion Older adults with vitamin D deficiency and COVID-19 may demonstrate worse morbidity outcomes. Vitamin D status may be a useful prognosticator.   Mental Disorders Forecast Chronic Physical Diseases, Premature Death University of Michigan, January 22, 2021 Poor early-life mental health may jeopardize later-life physical health, according to a new study led by a University of Michigan researcher. The study, published in the journal JAMA Network Open, indicates that people who experience psychiatric conditions when they are young are likely to experience excess age-related physical diseases when they are older. Leah Richmond-Rakerd, U-M assistant professor of psychology, and colleagues found that this association cannot be explained by preexisting physical illness; they ruled out the possibility of reverse causation in which having a physical illness precipitates mental health problems. Prior studies had not taken this into account. This association is present across different mental disorders and different physical diseases, she said. The researchers conducted a nationwide hospital-register study of 2.3 million New Zealanders—aged 10-60 years at baseline—followed across three decades (1988 to 2018). They tested whether individuals with mental disorders are at increased risk for subsequent chronic physical diseases and premature mortality. Richmond-Rakerd and colleagues collected information about hospital admissions for different mental disorders, such as substance use disorders, psychotic disorders, mood disorders, anxiety disorders and self-harm behavior. In addition, researchers collected information about hospital admissions for different chronic physical diseases, ranging from coronary heart disease to cancer. Across the 30-year period, individuals with mental disorders were more likely to develop subsequent physical diseases and they also died earlier than people without mental disorders, the study showed. They also experienced more medical hospitalizations, spent more time in hospitals for physical-disease treatment and accumulated more associated health care costs. These associations were present across all age groups and in both men and women. The findings indicate that addressing mental health problems in early life might be a window of opportunity for preventing future physical diseases, Richmond-Rakerd said. They also suggest the importance of joined-up services, or integrated care. “Our health care system often divides treatment between the brain and the body,” she said. “Integrating the two could benefit population health.” Richmond-Rakerd said they chose New Zealand because there it is possible to link hospital registers and other administrative databases for the entire population of the country. The study’s co-authors are Stephanie D’Souza and Barry Milne of the University of Auckland, Avshalom Caspi and Terrie Moffitt of Duke University and King’s College London.   'Aging well' greatly affected by hopes and fears for later life, study finds Oregon State University, January 21, 2021   If you believe you are capable of becoming the healthy, engaged person you want to be in old age, you are much more likely to experience that outcome, a recent Oregon State University study shows. "How we think about who we're going to be in old age is very predictive of exactly how we will be," said Shelbie Turner, a doctoral student in OSU's College of Public Health and Human Sciences and co-author on the study. Previous studies on aging have found that how people thought about themselves at age 50 predicted a wide range of future health outcomes up to 40 years later -- cardiovascular events, memory, balance, will to live, hospitalizations; even mortality.  "Previous research has shown that people who have positive views of aging at 50 live 7.5 years longer, on average, than people who don't," said Karen Hooker, co-author of the study and the Jo Anne Leonard Petersen Endowed Chair in Gerontology and Family Studies at OSU.  Because self-perceptions of aging are linked to so many major health outcomes, Hooker and Turner wanted to understand what influences those perceptions. Their study looked specifically at the influence of two factors: self-efficacy associated with possible selves, meaning a person's perceived ability to become the person they want to be in the future; and optimism as a general personality trait.  The researchers measured self-perception of aging by having respondents say how strongly they agreed or disagreed with statements such as, "Things keep getting worse as I get older," "I have as much pep as I had last year," "As you get older, you are less useful." They measured optimism in a similar way, with respondents ranking their agreement with statements like "In uncertain times I usually expect the best."  To measure self-efficacy, the study used a dataset that compiled survey responses from older adults where they listed two "hoped-for" future selves and two "feared" future selves, and ranked how capable they felt of becoming the person they hoped to be and avoiding becoming the person they feared to be.  Among the "hoped for" selves were things like "A social person with a strong network of friends" and "A healthy, active person." Examples of "feared" selves were "Chronically sick and in pain," "Being dependent on others for my day-to-day needs" and "A cranky, angry old woman."  Results showed that, as predicted, higher optimism was associated with more positive self-perception of aging. Both "hoped-for" self-efficacy and "feared" self-efficacy were also significantly associated with self-perception of aging, above and beyond optimism as a trait.  A major factor in how people see their own aging selves is internalizing ageist stereotypes, the researchers said. Examples of such stereotypes include assumptions that older adults are bad drivers, or suffer memory problems, or are unable to engage in physical activity anymore.  "Kids as young as 4 years old already have negative stereotypes about old people," Hooker said. "Then, of course, if you're lucky enough to live to old age, they eventually apply to you."  Those stereotypes get reinforced every time an older adult forgets something and jokes, "Another senior moment!" But the researchers say these thought patterns can do real harm. "People need to realize that some of the negative health consequences in later life might not be biologically driven. The mind and the body are all interwoven," Hooker said. "If you believe these bad things are going to happen, over time that can erode people's willingness or maybe even eventually their ability to engage in those health behaviors that are going to keep them as healthy as they can be."  A way to mitigate those negative stereotypes about aging is to promote intergenerational relationships, so younger people can see older adults enjoying happy, healthy lives.  "The more you're around older people, the more you realize that it's not all bad," Turner said. "Older people can do some things better than young people do. Increasing opportunities for intergenerational relationships is one way we can make people more optimistic about aging."   Over half of cannabis users with Parkinson's disease report clinical benefits University Medical Center Hamburg-Eppendorf (Germany), January 26, 2021   With medicinal cannabis now legalized in many parts of the world, there is growing interest in its use to alleviate symptoms of many illnesses including Parkinson's disease (PD). According to results of a survey of PD patients in Germany in the Journal of Parkinson's Disease, over 8% of patients with PD reported using cannabis products and more than half of those users (54%) reported a beneficial clinical effect. Cannabis products containing THC (tetrahydrocannabinol, the main psychoactive compound of cannabis) can be prescribed in Germany when previous therapies are unsuccessful or not tolerated, and where cannabis can be expected with not a very unlikely chance to relieve disabling symptoms. CBD (pure cannabidiol, derived directly from the hemp plant, a cousin of the marijuana plant) is available without a prescription from pharmacies and on the internet. "Medical cannabis was legally approved in Germany in 2017 when approval was given for therapy-resistant symptoms in severely affected patients independent of diagnosis and without clinical evidence-based data," explained lead investigator Prof. Dr. med. Carsten Buhmann, Department of Neurology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany. "PD patients fulfilling these criteria are entitled to be prescribed medical cannabis, but there are few data about which type of cannabinoid and which route of administration might be promising for which PD patient and which symptoms. We also lack information about the extent to which the PD community is informed about medicinal cannabis and whether they have tried cannabis and, if so, with what result." Investigators aimed to assess patient perceptions of medicinal cannabis as well as evaluate the experiences of patients already using cannabis products. They performed a nationwide, cross-sectional, questionnaire-based survey among members of the German Parkinson Association (Deutsche Parkinson Vereinigung e.V.), which is the largest consortium of PD patients in German-speaking countries with nearly 21,000 members. Questionnaires were sent out in April 2019 with the association's membership journal and were also distributed in the investigators' clinic. Over 1,300 questionnaires were analyzed; results showed that interest in the PD community in medical cannabis was high, but knowledge about different types of products was limited. Fifty-one percent of respondents were aware of the legality of medicinal cannabis, and 28% were aware of the various routes of administration (inhaling versus oral administration), but only 9% were aware of the difference between THC and CBD.  More than 8% of patients were already using cannabinoids and more than half of these users (54%) reported that it had a beneficial clinical effect. The overall tolerability was good. Over 40% of users reported that it helped manage pain and muscle cramps, and more than 20% of users reported a reduction of stiffness (akinesia), freezing, tremor, depression, anxiety, and restless legs. Patients reported that inhaled cannabis products containing THC were more efficient in treating stiffness than oral products containing CBD but were slightly less well tolerated.  Patients using cannabis tended to be younger, living in large cities, and more aware of the legal and clinical aspects of medicinal cannabis. Sixty-five percent of non-users were interested in using medicinal cannabis, but lack of knowledge and fear of side effects were reported as main reasons for not trying it.  "Our data confirm that PD patients have a high interest in treatment with medicinal cannabis but lacked knowledge about how to take it and especially the differences between the two main cannabinoids, THC and CBD," noted Prof. Dr. med. Buhmann. "Physicians should consider these aspects when advising their patients about treatment with medicinal cannabis. The data reported here may help physicians decide which patients could benefit, which symptoms could be addressed, and which type of cannabinoid and route of administration might be suitable." "Cannabis intake might be related to a placebo effect because of high patient expectations and conditioning, but even that can be considered as a therapeutic effect. It has to be stressed, though, that our findings are based on subjective patient reports and that clinically appropriate studies are urgently needed," he concluded.  Bastiaan R. Bloem, MD, PhD, Director, Radboudumc Center of Expertise for Parkinson & Movement Disorders, Nijmegen, The Netherlands, and Co-Editor-in Chief of the Journal of Parkinson's Disease, added: "These findings are interesting in that they confirm a widespread interest among patients in the use of cannabis as a potential treatment for people living with PD. It is important to emphasize that more research is needed before cannabis can be prescribed as a treatment, and that guidelines currently recommend against the use of cannabis, even as self-medication, because the efficacy is not well established, and because there are safety concerns (adverse effects include among others sedation and hallucinations). As such, the present paper mainly serves to emphasize the need for carefully controlled clinical trials to further establish both the efficacy and safety of cannabis treatment."   Covid lockdown loneliness linked to more depressive symptoms in older adults University of Exeter (UK), January 22, 2021   Loneliness in adults aged 50 and over during the COVID-19 lockdown was linked to worsening depressive and other mental health symptoms, according to a large-scale online study.  Loneliness emerged as a key factor linked to worsening symptoms of depression and anxiety in a study of more than 3,000 people aged 50 or over led by the University of Exeter and King's College London, and funded by The National Institute for Health Research (NIHR) Maudsley Biomedical Research Centre (BRC) .  Researchers had access to data going back to 2015 for participants of the PROTECT online study. They also found that a decrease in physical activity since the start of the pandemic was associated with worsening symptoms of depression and anxiety during the pandemic. Other factors included being female and being retired.  Dr Byron Creese, of the University of Exeter Medical School, who led the study, said: "Even before the pandemic, loneliness and physical activity levels were a huge issue in society, particularly among older people. Our study enabled us to compare mental health symptoms before and after COVID-19 in a large group of people aged 50 and over. We found that during lockdown, loneliness and decreased physical activity were associated with more symptoms of poor mental health, especially depression. It's now crucial that we build on this data to find new ways to mitigate risk of worsening mental health during the pandemic." The study found that before the pandemic, lonely people would report an average of two symptoms of depression for at least several days over the previous last two weeks. During lockdown, lonely people reported either an increase in frequency of depressive symptoms, to more than half the days in the two week period, or a new symptom for at least several days in that timeframe. In people who were not lonely, levels of depressive symptoms were unaffected.  PROTECT began in 2011, and has 25,000 participants signed up. Designed to understand the factors involved in healthy ageing, the innovative study combines detailed lifestyle questionnaires with cognitive tests that assess aspects of brain function including memory, judgment and reasoning over time. In May, researchers included a new questionnaire designed to assess the impact of COVID-19 on health and wellbeing. Running from May 13 to June 8, the questionnaire was completed by 3,300 people, of which 1,900 were long-standing PROTECT participants. The study is continuing to run so that longer term outcomes can be assessed.  Zunera Khan, Research Portfolio Lead at Institute of Psychiatry, Psychology & Neuroscience said "We've found links between loneliness and a drop in physical exercise and worsening mental health symptoms. It should be within our power to find ways of keeping people socially engaged and active. Our online PROTECT platform ultimately aims to find new ways to engage people in their homes, however, technology can only be part of the picture. We need to ensure we can find new ways to help people stay active and social, whether they are online or not." Professor Clive Ballard, Executive Dean and Pro-Vice Chancellor of the University of Exeter Medical School, who leads PROTECT, said: "We are only just beginning to learn the impact that COVID-19 is having on the health and wellbeing of older people. For example, the effect of any economic impact may not yet have emerged. Our large scale study will span a number of years, and will help us understand some of the longer-term effects of COVID-19 on mental health and wellbeing, and ultimately, on whether this has any knock-on effect on aspects of ageing, such as brain function and memory. " The study plans to conduct further analysis on groups at particularly high risk, such as people with cognitive impairment and those with caring rolesG

With five different systems for the suppression of resurgent Covid now in operation across the UK and Ireland, Alex Salmond asks two world-ranking public health experts what approach might work. Newly elected President of the BMA Professor Sir Harry Burns and Dr Bharat Pankhania from the University of Exeter Medical School suggest a way through the mixed messages which have courted disaster.

Everyday People Living Inspirational Lives is a podcast that shares the inspirational stories of some amazing people who live in the communities that we are all part of. We were super lucky to be approached by host Ian Pitchford, who sat down (remotely, of course!) with WEM Founder Mark Hannaford to discuss the who, what and why of WEM.  ** The abstract below is taken from the Everyday People Living Inspirational Lives podcast:  Mark is world’s first honorary associate professor awarded for his work in Extreme Medicine by the University of Exeter Medical School and is the founding director of World Extreme Medicine and Across the Divide Expeditions and a Fellow of both the Royal Geographical Society and the Royal Society of Arts.   A former special forces reserve soldier, a professional photographer, dogsled guide, remote boat handler and peripatetic explorer, Mark has been involved with expeditions for over 30 years and has led and organised expeditions to all of the world’s continents, in the desert and marine environments but also in polar regions, at altitude and has been involved in adventurous pursuits on all of the worlds five continents. Mark is also an award-winning photographer with images published in the Sunday Times, Telegraph, Rough Guides and National Geographic. He is also honorary aquanaut, an International Fellow of the famous Explorers Club of New York, a faculty member of the Space and Aviation Medicine course at the University of Texas Medical Board and Pacific University, Oregon. At A Mind 4 Adventure, we are very proud to be associated with Mark. Listen what inspires him as he is so key in the inspiration of others within the community he serves. ** Hear from more Everyday People Living Inspirational Lives via Ian's podcast, available here.   Mark will open this years Virtual World Extreme Medicine Conference, 17th and 18th October, as well as chairing sessions with a host of other incredible people living inspirational lives. Grab your tickets today > http://bit.ly/BookWEM20  

Dr Megan O’Hare interviews Professor Bart De Strooper and Professor David Llewellyn, discussing the new UK Dementia Research Institute and DEMON Network partnership to unlock the potential of Artificial Intelligence (AI). Professor Bart De Strooper is National Director and Group Leader at the UK Dementia Research Institute and Group Leader in his own research he looks at the cellular and molecular mechanisms underlying Alzheimer’s disease and other neurodegenerative disorders. Professor David Llewellyn is the DEMON Network Director and an Associate Professor at the University of Exeter Medical School and a Fellow at the Alan Turing Institute. His research aims to enhance the timely detection of dementia, with a focus on developing strategies for primary and secondary prevention using machine learning. The Deep Dementia Phenotyping (DEMON) Network brings together academics, clinicians and other partners from across the world, and now it has joined forced with the UK Dementia Research Institute. The aim of this new collaboration is to rapidly speed up the transformation of data into clinical and biologically relevant knowledge in neurodegeneration research, to strengthen links with clinical researchers and industry, and to drive forward experimental dementia research using data science and artificial intelligence. There is no universally agreed definition of AI. The term broadly refers to computing technologies that resemble processes associated with human intelligence, such as reasoning, learning and adaptation, sensory understanding, and interaction. An important feature of contemporary AI technologies is that they are increasingly able to make sense of varied and unstructured kinds of data – so what could happen when you combine AI with large amounts of health and societal data? The potential is amazing, and could be the key to unlocking improved dementia risk analysis, diagnosis and treatments. You can find out more about our panellists, and their work on our website www.dementiaresearcher.nihr.ac.uk. A transcript of this podcast is also available here https://www.dementiaresearcher.nihr.ac.uk/podcast-gate-and-dementia Like what you hear? Please review, like, and share our podcast - and don't forget to subscribe to ensure you never miss an episode. _____________________________________________________________________ For more information on the collaboration visit: https://ukdri.ac.uk/news-and-events/new-partnership-with-the-demon-network-will-drive-forward-experimental-dementia-research To join the DEMON Network visit: http://demondementia.com/ _____________________________________________________________________ This podcast is brought to you in association with Alzheimer's Research UK and Alzheimer's Society, who we thank for their ongoing support.

The United Kingdom, the country which pioneered public health legislation in the Victorian era, has struggled to test and trace in its efforts to tackle the challenge of coronavirus. Alex turns to Dr Bharat Pankhania of Exeter Medical School. With 20 years of expertise in infectious disease control, he details the problems of centralization and under-resourcing which have hampered the fight against the virus – particularly in England. Alex then speaks to Dr Christiansen and Kristina Hafoss MP, who explain how the tiny Faroe Islands have conquered Covid-19 – not once, but twice – through local knowledge and rapid response.

A simple blood test to diagnose Alzheimer's disease -- on the wish list of many doctors, researchers and patients -- may be closer to becoming a reality, according to the results of studies presented virtually this week during the Alzheimer's Association International Conference 2020.In a study presented Tuesday at the conference and published in JAMA, a blood test to detect the tau protein, one of the hallmark signs of Alzheimer's, was as accurate as a spinal tap or a positron emission tomography (PET) scan, which are the current gold standards of diagnosis while a person is living.The test could also differentiate between different types of cognitive dementia and even flag early signs of Alzheimer's. While more research is required and such a test is likely still years away from being available, experts say the results are encouraging."This research represents an exciting step towards developing a blood test that could help identify Alzheimer's disease by focusing on specific sub-types of tau, one of the key proteins that becomes abnormal as part of the Alzheimer's disease changes in the brain," said Clive Ballard, professor of age-related disease at the University of Exeter Medical School, in the UK, who was not involved in the study."A reliable blood test for Alzheimer's disease would be a huge boost for dementia research, allowing scientists to test treatments at a much earlier stage which in turn could lead to a breakthrough for those living with dementia," said Dr. Rosa Sancho, head of research at Alzheimer's Research UK, who was also not involved in the study.Looking for a mutant proteinIn a three-part study, researchers from the United States and Sweden measured an abnormal version of the tau protein called p-tau217 and found more of that modified tau in the blood of people with Alzheimer's disease than in healthy participants.How does tau get into blood? It appears to cross the blood-brain barrier."Tau protein is modified and clumps abnormally in the brains of people with Alzheimer's disease and some frontotemporal dementias, and some of this tau protein leaks out of the brain into the blood," said Tara Spires-Jones, the deputy director of the Centre for Discovery Brain Sciences at the University of Edinburgh, who was not involved in the study.The researchers report the blood test can distinguish Alzheimer's disease from other types of dementia and Parkinson's with a high degree of accuracy -- 89% to 98%.Additionally, measuring p-tau217 levels may also be able to detect brain changes 20 years before dementia symptoms occur."This test, once verified and confirmed, opens the possibility of early diagnosis of Alzheimer's before the dementia stage, which is very important for clinical trials evaluating novel therapies that might stop or slow down the disease process," the researchers, led by Dr. Oskar Hansson from Lund University in Sweden, wrote.Another study, published Tuesday in the Journal of Experimental Medicine, also verified that p-tau217 was more closely related to amyloid buildup in the brain than other chemicals that have been investigated."These two papers add to increasing evidence that modified tau proteins in the blood can accurately reflect Alzheimer's disease in processes occurring in the brain," said Amanda Heslegrave, a senior research fellow at the UK Dementia Research Institute at University College London, who was not involved in the study.In your doctor's officeThe formation of brain proteins, amyloid and tau, into clumps of amyloid plaques and tau tangles are defining physical features of Alzheimer's disease, but they are hard to detect without expensive PET scans or invasive spinal taps, neither of which is routinely covered by insurance.Doctors are left with verbal and written tests of memory and cognitive impairment, combined with interviews with patients' family members and caregivers about their behavior. That approach makes it tough to accurately diagnosis Alzheimer's...

Boris Johnson's plan to get Britain back to work has been unveiled but how cautious should we be about easing the lockdown? Nick speaks to Andrew Griffith, Former chief business advisor to Boris Johnson and Conservative MP for Arundel and South Downs who suggeest we need to end lockdown now. On the other side of the debate is Dr Bharat Pankhania, Senior Clinical Lecturer at the University of Exeter Medical School and Former Public Health Consultant in communicable disease control who says now is not the time. Plus Secretary of State for Defence Ben Wallace speaks on behalf of the Government.

This podcast includes content funded by The British Podcast Awards and Wellcome Trust. How important is socialising for a person living with dementia? Penny visits a scheme in Devon which provides what it calls a different kind of day care. The Filo Project offers a high quality experience for small groups of older people in an intimate home setting. www.thefiloproject.co.uk Penny chats to co-founders, Libby Price and Liz Dennis, meets staff and clients, and experiences a Filo day for herself. She also talks to Linda Clare, Professor of Clinical Psychology of Ageing and Dementia at the University of Exeter Medical School, about her study exploring people’s experiences of living well with dementia. www.idealproject.org.uk With thanks to The British Podcast Awards and Wellcome Trust for including Discovering Dementia as part of the Pulse Award. Please complete the survey to give your views on the podcast at www.podcastviews.com This episode of Discovering Dementia was produced and presented by Penny Bell, with additional editing by Cheeka Eyers, and original music by Leila Mitwally. To get in touch, say hello on instagram @discoveringdementia Join the facebook group @dementiapodcast And check out twitter @dementiapodcast www.discoveringdementia.co.uk

Ira Pastor, ideaXme exponential health ambassador, interviews Dr. Magomed Khaidakov, Assistant Research Professor, Department of Internal Medicine, University of Arkansas for the Medical Sciences. https://www.amazon.com/Pessimistic-Gu... Ira Pastor Comments: Today we are going to be talking about mitochondria, among many other longevity and anti-aging themed topics. We're also going to talk a little bit about the role of pessimism and realism when it comes to the human translation of certain technologies, and why it is important to limit "messianic thinking" as much as possible. Mitochondria The mitochondria are double-membrane-bound organelles found in most eukaryotic organisms and are responsible for generating most of the cell's supply of adenosine triphosphate (ATP), used as a source of chemical energy. Thus mitochondria is termed the "powerhouse of the cell." Damage and subsequent dysfunction in mitochondria is an important factor in a range of human diseases due to their influence in cell metabolism. Mitochondrial disorders often present themselves as neurological disorders, but can also manifest as myopathies, diabetes, multiple endocrinopathy, and a variety of other systemic disorders. The mitochondrial genome represents the full genetic complement of a mitochondria and contains approximately 16,600 base pairs, encoding 37 genes, and the polypeptides it codes for are all subunits of enzyme complexes of the oxidative phosphorylation system. Also, mitochondrial dysfunction can not only be driven based on damage to these genes, but also to mitochondrial genes in the nucleus, leading to many rare diseases such as Friedreich's ataxia, hereditary spastic paraplegia, and Wilson's disease. Dr. Magomed Khaidakov: To discuss this, and many other topics, I am joined by Dr. Magomed Khaidakov, Assistant Research Professor, Department of Internal Medicine, University of Arkansas for the Medical Sciences. Dr. Khaidakov obtained his Doctor of Medicine (MD) from 1st Medical Institute, Moscow, Russia, his PhD in Molecular Biology, from the University of Victoria (UVIC), British Columbia, Canada and for the last few decades his primary research interests have been the biology of aging and degenerative pathologies, as well as identification and correction of biological design flaws that limit mammalian lifespan. He is also the author of the recently published book "Pessimistic Guide To Anti-Aging Research." We will hear from Dr. Khaidakov: About his background and an overview of the importance of mitochondria in both health and degenerative disease. An overview of his theories related to species-specific lifespans and the correlation with accumulation of large deletions in mitochondrial DNA. Other important areas of anti-aging research, and their limitations. A futuristic view of anti-aging technologies. Finally, his perspective on the longevity biotech community and places for pessimism and realism to have a role in critical thinking of novel approaches. Credits: Ira Pastor interview video, text, and audio. Follow Ira Pastor on Twitter:@IraSamuelPastor If you liked this interview, be sure to check out ourinterview with Dr. Lorna Harries, Professor of Molecular Genetics at University of Exeter Medical School. Follow ideaXme on Twitter:@ideaxm On Instagram:@ideaxme Find ideaXme across the internet including oniTunes, Stitcher, SoundCloud,YouTube, Radio Public,TuneIn Radio,I Heart Radio, Google Podcasts, Spotify and more. www.radioideaxme.com ideaXme is a global podcast, creator series and mentor programme. Our mission: Move the human story forward!™ ideaXme Ltd.

Áine Ní Tighearnaigh In Conversation with Professor Sotiris Vardoularkis, Professor of Global Environmental Health at the ANU National Centre for Epidemiology and Population Health. – Climate Change, the Canberra Air Quality Crisis and the Impact of Vulnerable Communities. We discuss climate change, the impact on vulnerable communities, the elderly, people with mental illness, the current Canberra Air Quality Crisis and the short and long-term impacts of bushfire smoke on health and mental well-being. Professor Vardoulakis also provides guidance on what measures we need to take individually, as a community and as a nation to address climate change into the future. "Sotiris is founding co-chair of the International Consortium for Urban Environmental Health and Sustainability (Healthy-Polis) and Honorary Professor at the European Centre for Environment and Human Health at University of Exeter Medical School. Previously he was Head of the Environmental Change Department at Public Health England and held academic positions at the London School of Hygiene and Tropical Medicine and the University of Birmingham. He was one of the lead authors of the first UK Climate Change Risk Assessment and contributor to the National Adaptation Programme. He served as a member of the NICE (National Institute for Health and Care Excellence, UK) Public Health Advisory Committee on Air Pollution. Over the last 20 years, he has advised national and local governments and international organizations, such as the World Health Organization and the European Parliament, on the health effects of climate change and air pollution, and on environmental sustainability and urban health. Sotiris has been involved in numerous research projects, including field studies, environmental modelling, risk assessment and policy analysis in Europe, Africa, Asia, Australia and the Pacific".

Ira Pastor, ideaXme exponential health ambassador and founder of Bioquark, interview Dr. Lorna Harries, Professor of Molecular Genetics at University of Exeter Medical School. Ira Pastor Comments Today as we continue our discussions on ideaXme pertaining to the biological hierarchy of life, we are going to journey into what I refer to as the "metabolic architecture of the cell", and all of the fascinating dynamics that surround our genomes and allow the information encoded within to impact the on-going physiological states of our health, disease, and aging processes. In doing so we will segue into a discussion around a category of biologic entities, broadly known as Ribonucleic acids (or RNA). RNA RNA is a polymeric molecule essential in various biological roles including coding, decoding, regulation and expression of genes. Cellular organisms use one of the primary forms of RNA, messenger RNA (mRNA) to convey genetic information from our DNA to direct synthesis of specific proteins integral in appropriate gene expression across our cell lineages. RNA silencing or "RNA interference" (RNAi) is the process by which protein production from a gene is turned off. The term "RNA therapeutics" means either the use of one of the other forms of regulatory RNAs (e.g., siRNAs, microRNA) directly as a therapeutic agent and/or the modulation of RNA-based processes with more traditional drugs (e.g. small molecules). Because RNA is central to all biological processes, there are numerous potential avenues for addressing human disorders at the RNA level including many chronic degenerative diseases, infections, and even aging processes themselves. Our guest today, who is an expert in this unique domain of biology and is going to take us further into the topic, is Professor Lorna Harries, Professor of Molecular Genetics, University of Exeter Medical School. Dr. Lorna Harries Dr. Harries has a PhD in Molecular Genetics from University College London, and set up the "RNA-Mediated Mechanisms of Disease Group" at the University of Exeter Medical School in 2006. Her team has a special focus on how RNA biology can influence both normal and disease states, from large-scale "omics" approaches, down to detailed assessment of specific mechanisms in specific genes. Dr. Harries leads the group's investigation into how and why we age, and the reason age is a major risk factor in diseases like Type-2 Diabetes. Her goal is to use the information the group uncovers to develop a new generation of anti-degenerative drugs. As many age-related diseases have common roots, causes and mechanisms, which arise from the failure of a few basic health-maintenance mechanisms that decline in efficiency as we age, the Harries lab feels by focusing and by targeting them, they will eventually be able to target multiple age-related diseases at once. Dr. Harries has written over 90 peer-reviewed articles and was awarded the Diabetes UK RD Lawrence Prize Lectureship in 2011. She is coordinator of the annual UEMS "Men in White" school outreach with Dr. John Chilton, an event that brings in year 9 students from schools stretching from South Devon to North Somerset and gives them hands-on experience of work in a research laboratory. Dr. Harries is also is a STEMnet ambassador as well as an Exeter Catalyst Champion for Public Engagement. On this show we will hear from Dr. Harries: About her background, how she became interested in science, molecular biology, and how she finds herself at the forefront of RNA biology and therapeutics. The history of RNA therapeutics and why according to her recent Nature article "It's Time for Scientists to Shout About RNA Therapies." An overview of RNA splicing, the spliceosome, splicing factors, and their respective roles in human ageing. Her work in RNA regulation of human cellular senescence. Her work in RNA regulation of Type-2 Diabetes. Her future visions for her work. Dr. Lorna Harries will be speaking at the following upcoming conferences: 6th Annual Middle East Diabetes Conference Dubai 29-30 Jan 2020 Splicing 2020 meeting Capirica 12-16 July 2020  Allergan Science of Aging meeting Monaco 30th March - 1st April 2020 (dates provisional!) Longevity Leaders London April 21-22 2020  

The UK has just seen it's hottest July on record, including the highest ever temperature recorded. With climate change in the forefront of our minds, it's timely that we have two editorials on the sustainability and health. Michael Depledge, emeritus professor of environment and human health at University of Exeter Medical School, and author of the editorial Time and Tide, explains how closely the oceans and seas are linked to human health. Also Gillian Leng, deputy chief executive and director of health and social care at NICE has ideas about what the NHS can do to become more sustainable, and how we could evaluate the impact treatments have on the planet. Read the two editorials Time and tide - https://www.bmj.com/content/366/bmj.l4671 A more sustainable NHS - https://www.bmj.com/content/366/bmj.l4930

Dr David Llewellyn from the University of Exeter Medical School answers our questions about his research on dementia misclassification when using brief cognitive assessments.

Professor Tamsin Ford, Professor of Child and Adolescent Psychiatry, University of Exeter Medical School, talks to Jo Carlowe, psychology journalist, about attachment and early intervention, and explains why schools are an important setting in relation to child mental health. Tamsin's work focuses on the effectiveness of interventions and services for children with poor mental health, such as the Incredible Years Classroom Management Course that is tested in the STARS trial. Tamsin will be speaking at the [Emanuel Miller Memorial Lecture and National Conference](https://www.acamh.org/event/miller19/), in London on Friday 8 March. Her discussion will be on 'The incredible years teacher programme – update on recent trials .'

In this podcast Adam Smith from University College London talks to Chris Roberts, Jayne Goodrick and Hilary Doxford. Three fantastic people who directly and indirectly live with the effects of dementia every days, and have spent many years, campaigning to improve dementia awareness and championing the importance of research. In this two part special filmed on location at University of Exeter Medical School, the panel give advice to early career researchers. Exploring their personal experiences as research participants, and what they would like to see done better.

In this podcast Adam Smith from University College London talks to Chris Roberts, Jayne Goodrick and Hilary Doxford. Three fantastic people who directly and indirectly live with the effects of dementia every days, and have spent many years, campaigning to improve dementia awareness and championing the importance of research. In this two part special filmed on location at University of Exeter Medical School, the panel give advice to early career researchers. Exploring their personal experiences as research participants, and what they would like to see done better.

Professor Tamsin Ford from Exeter Medical School and Professor Neil Humphrey from the Manchester Institute of Education talk about the STARS trial of the effectiveness and cost-effectiveness of the Incredible Years® Teacher Classroom Management programme in primary school children

Tamsin Ford is a Professor of Child and Adolescent Psychiatry at the University of Exeter Medical School. While Tamsin set out on her career path aiming to become an old age psychiatrist working as a clinician, she ended up as a child psychiatrist working in research. Discover more about Tamsin's career and her research group assessing the effectiveness of services and interventions which aim to support the mental health and wellbeing of children and young people.

The first prevalence studies estimated one in 2,500 children were autistic whereas the latest figures indicate around one in every 39 children is reported to have an autism diagnosis. Dr Ginny Russell discusses why we may have seen such an increase. Dr Ginny Russell is a Senior Research Fellow at the University of Exeter Medical School and the Department of Sociology. She will be speaking about time trends in diagnosis of autism at ACAMH’s upcoming Jack Tizard Memorial Lecture and National Conference.

Sebastian OLTEAN, Institute of Biomedical & Clinical Sciences University of Exeter Medical School, Exeter, UK speaks on "Novel anti-angiogenic compounds based on modulation of VEGF splicing". This movie has been recorded at ICGEB Trieste.

In 1880 Sir Francis Galton first identified a phenomenon in which people cannot visualize. Reports suggested that as much as 2.5% of the population may live this experience daily. Until now this phenomenon has remained largely unexplored. However, Cognitive neurologist Professor Adam Zeman, at the University of Exeter Medical School, has revisited this recently, including coining of the term "Aphantasia to describe the experience. In this episode, Abraham and RYANO talk about Aphantasia, in their typical "consumable psychology" style. Listen in, and remember that you can reach us directly at 775.525.0908, at info@wwdwwdpodcast.com, through the comments below OR on social via @wwdwwdpodcast or #wwdwwdpodcast.

Where do antibiotics end up after we've used them? The answer is almost everywhere – in our soils and crops, in our rivers and in our drinking water. Is this something we should be concerned about? And is it driving the evolution of resistance? In this Microbe Talk Extra, we spoke to Dr Will Gaze from the University of Exeter Medical School about antimicrobial resistance in the environment, and his lab's research on water treatment plants, coastal waters, and surfers' bums.

In this podcast Dr Raj Persaud discusses the cognitive assessment with Professor Adam Zeman, Professor of Cognitive and Behavioural Neurology at the University of Exeter Medical School.

The neurological examination is often approached with trepidation by psychiatrists but can be done quickly and reliably with practice. The best approach is to keep doing them as often as possible, but in order for them to be useful, and conducted without fear, it's advantageous to a have an understanding of what you are trying to achieve. In this podcast Professor Adam Zeman, Professor of Cognitive and Behavioural Neurology at the University of Exeter Medical School, explains to Dr Raj Persaud how to conduct a neurological examination.

Discussion led by Peter Baxter, editor of Developmental Medicine & Child Neurology, with Dr Christopher Morris of University of Exeter Medical School, UK and Prof. Christine Cans Epidemiologist at Grenoble University Hospital, France. Read the paper here: http://onlinelibrary.wiley.com/doi/10.1111/dmcn.12218/pdf

Throughout February, The Parents' Show will focus on ADHD and all its aspects for our parents, children and wider community. We have invited experts from around the UK to support us, provide best practice and help us promote greater understanding. First up, we are speaking to Dr Abby Russell from the University of Exeter Medical School indepth about ADHD. She will be answering a comprehensive list of questions. We are proudly sponsored by Rayden Solicitors