POPULARITY
Categories
Michelle is climbing the bougie power rankings. Why do the 49ers NOT have a QB controversy? Have the standards lowered for the Steelers? BREAKING NEWS: Jayden Daniels has NOT been placed on IR. We play Can He or Canty and there's a word Nuno is having a tough time pronouncing. Canty's Best Bet & UnSportsmanLike Moments of the Day: Olivier Rioux is very tall! Learn more about your ad choices. Visit podcastchoices.com/adchoices
Michelle is climbing the bougie power rankings. Why do the 49ers NOT have a QB controversy? Have the standards lowered for the Steelers? BREAKING NEWS: Jayden Daniels has NOT been placed on IR. We play Can He or Canty and there's a word Nuno is having a tough time pronouncing. Canty's Best Bet & UnSportsmanLike Moments of the Day: Olivier Rioux is very tall! Learn more about your ad choices. Visit podcastchoices.com/adchoices
Dive into the somber NFL world with the latest on a tragic loss and key roster insights as the Packers gear up for a Monday night battle against the Eagles. We break down Philadelphia's strengths and vulnerabilities, from Jalen Hurts' up-and-down play to their dominant defensive tackles, while touching on Packers' injury updates that offer some optimism. It's a comprehensive look at what Green Bay faces in this pivotal matchup. Heartbreaking details on Cowboys' Marshawn Kneeland's passing and resources for mental health support NFL updates including Kyler Murray on IR, Sauce Gardner's return, and Packers' practice notes with Matthew Golden day-to-day In-depth Eagles roster analysis: Hurts' elite passer rating, explosive receivers like AJ Brown and Devonta Smith, Saquon Barkley's recent surge, and a formidable defense led by Jalen Carter and Zach Baun Quick hits on Eagles' special teams and potential Packers exploitation opportunities This episode is brought to you by PrizePicks! Use code PACKDADDY and visit https://prizepicks.onelink.me/LME0/PACKDADDY to get started with America's #1 fantasy sports app. Subscribe, rate, and review on your favorite platform to stay updated on all things Packers—your support keeps us going! Follow @Pack_Daddy on X for more discussions and join the conversation with #PackernetPodcast. To advertise on this podcast please email: ad-sales@libsyn.com Or go to: https://advertising.libsyn.com/packernetpodcast
The Seahawks have a couple injuries to their receiver room but thankfully picked up Rashid Shaheed at the trade deadline. Bump & Stacy break down what this means for the Seahawks offense going into week 10. // Headline Rewrites: The Broncos beat the Raiders 10-7 in one of the worst games of football since the invention of the forward pass. Unbelievably Jayden Daniels isn’t expected to land on IR after he dislocated his elbow against the Seahawks. The 6-2 Rams take on the 6-3 49ers on Sunday. // Bump & Stacy talk about the Mariners offseason intentions after hearing some comments from Mariners GM Justin Hollander. Hollander made it clear that Josh Naylor is priority number one. // It’s time to be bold and give our takes for this Sunday’s Seahawks game vs the Cardinals in Bold Take Friday!
Prospect Insider’s Jason Churchill joins the show to talk about the market in the MLB offseason. Are there many high priced talents available on the free agent market or will it be more of a trade-style offseason for most teams? Who is Jason looking forward to see make the jump to the big leagues from the minor? // Headline Rewrites: The Broncos beat the Raiders 10-7 in one of the worst games of football since the invention of the forward pass. Unbelievably Jayden Daniels isn’t expected to land on IR after he dislocated his elbow against the Seahawks. The 6-2 Rams take on the 6-3 49ers on Sunday. // NFL Headlines: How did Sauce Gardner end up on the Colts? He never asked for a trade but was traded away. Sean Payton is not thrilled with his team’s offensive struggles and penalties. // Bump & Stacy go through the NFL Week 10 storylines, one being are the Colts about to go on a skid?
Michelle is climbing the bougie power rankings. Why do the 49ers NOT have a QB controversy? Have the standards lowered for the Steelers? BREAKING NEWS: Jayden Daniels has NOT been placed on IR. We play Can He or Canty and there's a word Nuno is having a tough time pronouncing. Canty's Best Bet & UnSportsmanLike Moments of the Day: Olivier Rioux is very tall! Learn more about your ad choices. Visit podcastchoices.com/adchoices
Michelle is climbing the bougie power rankings. Why do the 49ers NOT have a QB controversy? Have the standards lowered for the Steelers? BREAKING NEWS: Jayden Daniels has NOT been placed on IR. We play Can He or Canty and there's a word Nuno is having a tough time pronouncing. Canty's Best Bet & UnSportsmanLike Moments of the Day: Olivier Rioux is very tall! Learn more about your ad choices. Visit podcastchoices.com/adchoices
Dive into the somber NFL world with the latest on a tragic loss and key roster insights as the Packers gear up for a Monday night battle against the Eagles. We break down Philadelphia's strengths and vulnerabilities, from Jalen Hurts' up-and-down play to their dominant defensive tackles, while touching on Packers' injury updates that offer some optimism. It's a comprehensive look at what Green Bay faces in this pivotal matchup. Heartbreaking details on Cowboys' Marshawn Kneeland's passing and resources for mental health support NFL updates including Kyler Murray on IR, Sauce Gardner's return, and Packers' practice notes with Matthew Golden day-to-day In-depth Eagles roster analysis: Hurts' elite passer rating, explosive receivers like AJ Brown and Devonta Smith, Saquon Barkley's recent surge, and a formidable defense led by Jalen Carter and Zach Baun Quick hits on Eagles' special teams and potential Packers exploitation opportunities This episode is brought to you by PrizePicks! Use code PACKDADDY and visit https://prizepicks.onelink.me/LME0/PACKDADDY to get started with America's #1 fantasy sports app. Subscribe, rate, and review on your favorite platform to stay updated on all things Packers—your support keeps us going! Follow @Pack_Daddy on X for more discussions and join the conversation with #PackernetPodcast. To advertise on this podcast please email: ad-sales@libsyn.com Or go to: https://advertising.libsyn.com/packernetpodcast
In hour 2 of The Drive, Zach and Phil dive into Bo Nix's performance from last night. We compare Nix's stats this season through 10 games to Russell Wilson's 2023 stats through 10 games. How much blame does Sean Payton deserve for Nix's poor play? Did Payton jump the gun when calling his shot that Nix would be a top quarterback in the NFL and that he develops quarterbacks better than other people? Today's "Three Count" features the Broncos already having four games this season with double-digit penalties, the news that Jayden Daniels will not need surgery and will not go on IR making it a possibility he plays against Denver, and Colin Cowherd suggesting the Broncos could look for a replacement for Bo Nix. What are the guys looking for from the Nuggets tonight as they take on the Warriors?
Michelle is climbing the bougie power rankings. Why do the 49ers NOT have a QB controversy? Have the standards lowered for the Steelers? BREAKING NEWS: Jayden Daniels has NOT been placed on IR. We play Can He or Canty and there's a word Nuno is having a tough time pronouncing. Canty's Best Bet & UnSportsmanLike Moments of the Day: Olivier Rioux is very tall! Learn more about your ad choices. Visit podcastchoices.com/adchoices
00:00 - 11:13 - Coach Bob Lovell from Indiana Sports Talk joins the show! Coach Lovell and JMV discuss the weekend of high school football, and also talk some college football/basketball! 11:14 - 29:30 - Joel Erickson from the IndyStar joins the show live from Berlin ahead of the Colts showdown with the Falcons in Germany! They talk about the news that DeForest Buckner is heading to IR, and if the Colts will see him back on the field this season. 29:31 - 41:43 - Mike Wells from ESPN Radio joins the show! Mike and JMV discuss the impact the IU football turnaround has had on the campus and enthusiasm in Bloomington.Support the show: https://1075thefan.com/the-ride-with-jmv/See omnystudio.com/listener for privacy information.
00:00 – 24:53 – JMV is out at Twin Peaks in Greenwood for a Bud Light Blue Friday! He kicks things off by previewing Colts-Falcons in Berlin! He also discusses the Pacers and some of the moves they have made recently. 24:54 – 39:09 – Coach Bob Lovell from Indiana Sports Talk joins the show! Coach Lovell and JMV discuss the weekend of high school football, and also talk some college football/basketball! 39:10 – 44:25 – JMV wraps up the 1st hour of the show! 44:26 – 1:07:20 – Joel Erickson from the IndyStar joins the show live from Berlin ahead of the Colts showdown with the Falcons in Germany! They talk about the news that DeForest Buckner is heading to IR, and if the Colts will see him back on the field this season. 1:07:21 – 1:20:44 – Mike Wells from ESPN Radio joins the show! Mike and JMV discuss the impact the IU football turnaround has had on the campus and enthusiasm in Bloomington. 1:20:45 – 1:25:10 - JMV wraps up another hour of the show! 1:25:11 – 1:46:47 – JMV takes some calls from listeners of the show! 1:46:47 – 1:55:48 – JMV continues the show by reflecting on some more German songs, as well as remembering his friend Robin Miller. 1:55:49 – 2:07:24 - JMV wraps up another edition of the show! Support the show: https://1075thefan.com/the-ride-with-jmv/See omnystudio.com/listener for privacy information.
Yahoo Sports' Jason Fitz and Charles Robinson break down the Cardinals' placement of Kyler Murray on IR and what that means for him as well as the franchise moving forward. The guys also discuss Sauce Gardner's "tradeable" contract extension with the Jets and how it affects his move to the Colts. Plus, is Daniel Jones Indy's QB of the future? And is Kevin Stefanski giving up playcalling for the Browns a bad sign? Closing out the show the guys discuss what coaches are on the hot seat and Tom Brady's wild move to clone his pet dog. Also, Derrick Henry joins Andrew Siciliano to discuss the Baltimore Ravens 2-game win streak and more. Hear about it all on the latest episode of Inside Coverage!(0:48) - Cardinals place QB Kyler Murray on IR(10:49) - Jets made Sauce Gardner's contract "tradeable"(19:25) - Is Daniel Jones the long term QB for Indy?(25:07) - Derrick Henry joins the show!(34:12) - Kevin Stefanski gives up playcalling for the Browns(43:36) - What coaches are on the hot seat?(51:53) - Jayden Daniels' injury saga continues(56:51) - Tom Brady cloned his pet dog!?
(0:00) Cowboys-Quinnen Williams trade grade, Kyler Murray on IR (37:32:) Ja Morant's lack of trade value (48:53) Nick's Tiers (01:10:08) Must-Win (01:23:44) Luka vs. Wemby (01:30:08) Sauce Gardner's debut (01:33:54) Matthew Stafford MVP race, Caleb Williams (01:54:56) Ben Johnson joins (02:16:01: Why trades are good for football Learn more about your ad choices. Visit podcastchoices.com/adchoices
Evan, Canty, & Michelle can't figure out how LeBron James will fit into a Lakers team that's 7-2 after a 118-116 win over the Spurs last night. Kyler Murray was placed on IR and Canty believes this is a soft benching leading to a long goodbye. Nuno was angrily tweeting about Benfica yesterday and there's a conspiracy against Evan at the NYC office. How many players have been unable to shake the label attached to them? Learn more about your ad choices. Visit podcastchoices.com/adchoices
Ben Maller talks about Kyler Murray landing on the IR with the Cardinals claiming he has a foot injury, is there more to the story? Also, Jets RB Breece Hall saying he never formally requested a trade from the Jets but refused to say if he wanted one, if the Colts should take it slow with Sauce Gardner, and much more!See omnystudio.com/listener for privacy information.
Evan, Canty, & Michelle can't figure out how LeBron James will fit into a Lakers team that's 7-2 after a 118-116 win over the Spurs last night. Kyler Murray was placed on IR and Canty believes this is a soft benching leading to a long goodbye. Nuno was angrily tweeting about Benfica yesterday and there's a conspiracy against Evan at the NYC office. How many players have been unable to shake the label attached to them? Learn more about your ad choices. Visit podcastchoices.com/adchoices
(0:00) Big Shield talk(9:00) Jets trade Sauce Gardner & Quinnen Williams(17:00) Shane Steichen “really excited” to add Sauce Gardner(21:00) Daniel Jones on Gardner(24:00) ESPN/YouTube TV dilemma(26:00) Rico Dowdle fined for TD celebration(28:30) Kyler Murray placed on IR(40:00) Derrick Henry joins the show Hosted by Simplecast, an AdsWizz company. See pcm.adswizz.com for information about our collection and use of personal data for advertising.
Dive into the frustrating world of Packers critiques where stats clash with fan myths, exposing why arbitrary opinions fall flat against real data. Ryan unpacks the shotgun vs. under center debate, tears apart Eric Hubbs' bold claims on LaFleur's play calling, and explores Benjamin Solak's take on Green Bay's missing dominance. From execution breakdowns to overlooked truths, this episode challenges everything you thought you knew about the offense. Dusty Evely's stats reveal shotgun's edge over under center, debunking calls for change with hard numbers on yards and success rates. Hubbs' article gets roasted: "Matt LaFleur has no balls" meets reality checks on fourth-down risks and passing depths. Solak's analysis highlights execution friction—why soft defenses force dinks and dunks, but Packers lack YAC without Tucker Kraft. Quick hits on news like Kraft on IR, new tight end signings, and minor roster moves, plus a tease on Thursday's Raiders-Broncos matchup. This episode is brought to you by PrizePicks! Use code PACKDADDY and visit https://prizepicks.onelink.me/LME0/PACKDADDY to get started with America's #1 fantasy sports app. Drop your hot takes on LaFleur's play calling or these stats in the comments—let's debate! Subscribe, rate, and review to keep the Packernet Podcast rolling strong. Catch tomorrow's episode for more on roster updates and game previews. To advertise on this podcast please email: ad-sales@libsyn.com Or go to: https://advertising.libsyn.com/packernetpodcast Help keep the show growing and check out everything I'm building across the Packers and NFL world: Support: Patreon: www.patreon.com/pack_daddy Venmo: @Packernetpodcast CashApp: $packpod Projects: Grade NFL Players ➜ fanfocus-teamgrades.lovable.app Packers Hub ➜ packersgames.com Create NFL Draft Big Boards ➜ nfldraftgrades.com Watch Draft Prospects ➜ draftflix.com Screen Record ➜ pause-play-capture.lovable.app Global Economics Hub ➜ global-economic-insight-hub.lovable.app
Evan, Canty, & Michelle can't figure out how LeBron James will fit into a Lakers team that's 7-2 after a 118-116 win over the Spurs last night. Kyler Murray was placed on IR and Canty believes this is a soft benching leading to a long goodbye. Nuno was angrily tweeting about Benfica yesterday and there's a conspiracy against Evan at the NYC office. How many players have been unable to shake the label attached to them? Learn more about your ad choices. Visit podcastchoices.com/adchoices
Primetime with Isaac and Suke: Kyler Murray headed to IR, World Series Ratings, Blazers vs OKC, and Who's that new face behind the board?
Evan, Canty, & Michelle can't figure out how LeBron James will fit into a Lakers team that's 7-2 after a 118-116 win over the Spurs last night. Kyler Murray was placed on IR and Canty believes this is a soft benching leading to a long goodbye. Nuno was angrily tweeting about Benfica yesterday and there's a conspiracy against Evan at the NYC office. How many players have been unable to shake the label attached to them? Learn more about your ad choices. Visit podcastchoices.com/adchoices
Dive into the frustrating world of Packers critiques where stats clash with fan myths, exposing why arbitrary opinions fall flat against real data. Ryan unpacks the shotgun vs. under center debate, tears apart Eric Hubbs' bold claims on LaFleur's play calling, and explores Benjamin Solak's take on Green Bay's missing dominance. From execution breakdowns to overlooked truths, this episode challenges everything you thought you knew about the offense. Dusty Evely's stats reveal shotgun's edge over under center, debunking calls for change with hard numbers on yards and success rates. Hubbs' article gets roasted: "Matt LaFleur has no balls" meets reality checks on fourth-down risks and passing depths. Solak's analysis highlights execution friction—why soft defenses force dinks and dunks, but Packers lack YAC without Tucker Kraft. Quick hits on news like Kraft on IR, new tight end signings, and minor roster moves, plus a tease on Thursday's Raiders-Broncos matchup. This episode is brought to you by PrizePicks! Use code PACKDADDY and visit https://prizepicks.onelink.me/LME0/PACKDADDY to get started with America's #1 fantasy sports app. Drop your hot takes on LaFleur's play calling or these stats in the comments—let's debate! Subscribe, rate, and review to keep the Packernet Podcast rolling strong. Catch tomorrow's episode for more on roster updates and game previews. To advertise on this podcast please email: ad-sales@libsyn.com Or go to: https://advertising.libsyn.com/packernetpodcast Help keep the show growing and check out everything I'm building across the Packers and NFL world: Support: Patreon: www.patreon.com/pack_daddy Venmo: @Packernetpodcast CashApp: $packpod Projects: Grade NFL Players ➜ fanfocus-teamgrades.lovable.app Packers Hub ➜ packersgames.com Create NFL Draft Big Boards ➜ nfldraftgrades.com Watch Draft Prospects ➜ draftflix.com Screen Record ➜ pause-play-capture.lovable.app Global Economics Hub ➜ global-economic-insight-hub.lovable.app
NEWS: Judkins healthy; Kyler to IR; Bucky? Dowdle
Evan, Canty, & Michelle can't figure out how LeBron James will fit into a Lakers team that's 7-2 after a 118-116 win over the Spurs last night. Kyler Murray was placed on IR and Canty believes this is a soft benching leading to a long goodbye. Nuno was angrily tweeting about Benfica yesterday and there's a conspiracy against Evan at the NYC office. How many players have been unable to shake the label attached to them? Learn more about your ad choices. Visit podcastchoices.com/adchoices
Kramer Sansone is back to discuss the Cardinals' placing Kyler Murray on IR and rolling with Jacoby Brissett for at least the next 4 weeks. CJ Stroud is likely out in Week 10, and the biggest impact players from the NFL trade deadline. We wrap it up with the waiver watcher and the top plays in Week 10. Subscribe: https://youtu.be/eBK-2IGrt5c Learn more about your ad choices. Visit megaphone.fm/adchoices
Wolf and Luke react to Kyler Murray going to the IR and discuss what type of boost Jalen Green could give the Phoenix Suns.
Dr. Monty Pal and Dr. Pauline Funchain discuss the latest efforts to diagnose, prevent, and treat the series of immune-related adverse events that have emerged in the era of immunotherapy. TRANSCRIPT Dr. Monty Pal: Hello, and welcome to the ASCO Daily News Podcast. I am Monty Pal, a medical oncologist, professor and vice chair of medical oncology at the City of Hope Comprehensive Cancer Center in Los Angeles, California. Now, it is probably no surprise to this audience that immunotherapy has transformed the treatment landscape for multiple cancer types. It remains a pillar of modern oncology. Having said that, I think we have all been baffled by certain toxicities that we run into in the clinic. Today, I am delighted to be joined by Dr Pauline Funchain to discuss some of the checkpoint inhibitor toxicities that people struggle with most. And we will also touch on some side effects of immunotherapy beyond checkpoint inhibitors: CAR-T cells, bispecifics, so on and so forth. Dr Funchain is a dear friend, and she is an associate professor and associate director of cancer research training and education at the Stanford Cancer Institute. She is co-director of the Immunotherapy Toxicity Program and the Skin Cancer Genomics Program at Stanford, where she also serves as associate program director of hematology and oncology fellowship. Dr. Funchain is also the co-founder of ASPIRE, and we are going to talk about that a little bit today, the Alliance for the Support and Prevention of Immune-Related Events. FYI for listeners, if you are interested in our disclosures, they are available at the transcript of this episode. Pauline, thanks so much for joining us today. Dr. Pauline Funchain: Monty, thank you for this invitation. It is always great to talk. Dr. Monty Pal: So, for the audience, Pauline and I know each other from my days as a fellow at City of Hope. She was a resident at Harbor UCLA and a stellar resident at that. It has just been amazing to sort of see your career grow and blossom and to witness all the cool things that you are doing. ASPIRE, in particular, sort of caught my eye. So again, for listeners, this is the Alliance for the Support and Prevention of Immune-Related Events. Can you tell us a little bit briefly about the genesis of that, how that came about? Dr. Pauline Funchain: So, there was a bunch of us who were really struggling, I mean, all of us have struggled with these immune-related adverse events, these irAEs. You know, they are new disease states, and even though they look like autoimmune diseases, they tend to need a whole lot more steroid than autoimmune diseases do and they do not totally present in the same way. And in fact, you know, Triple-M, or Triple-M overlap syndrome, is a completely new irAE, a new immune state that we have never had before the advent of checkpoint inhibitor. And so a Triple-M, for those of you who are not as familiar, that is the constellation of myocarditis, myositis, and myasthenia gravis, something that never occurs as a natural autoimmune disease. So we were starting to realize that there were some major differences with these irAEs and autoimmune diseases. We could not treat them the right way. We really needed to learn more about them. And a bunch of us who had interest in this said, "Look, we really need to be all in one space to talk about what we are doing," because all of our treatments were our own little homegrown brews, and we needed to really get together and understand how to treat these things, how to diagnose them, and then learn more about them. So, Dr. Alexa Meara from Ohio State, Dr. Kerry Reynolds from Mass Gen, we put together this research consortium, brought together all of our irAE friends, got our best subspecialists together in a research consortium, which is now only about a year and a half old. And we made this research consortium, the Alliance for Support of Prevention of Immune-Related Events, and we reached out to ASCO, and ASCO was so kind to grant us a [Alliance for Support and Prevention of Immune-Related adverse Events (ASPIRE)] Community of Practice. So we met for the first time as a Community of Practice at the ASCO Annual Meeting just this past June and really got an ASCO community together to really think about how to again, diagnose, prevent, treat irAEs. Dr Monty Pal: This is interesting to me. The ASCO Community of Practice phenomenon is something that I was not super familiar with. Can you explain to our listenership what is the ASCO Community of Practice model? If you have particular interests, how do you sort of get one started? Dr Pauline Funchain: Yeah, so ASCO has an entire page on their Community of Practice. There are multiple Community of Practice groups or COPs. There are ones for Supportive Oncology and Survivorship. There is Women in Oncology. There is a group for International Medical Graduates. And there is about, I think 10 or 12 now that have a physical presence at ASCO but also a virtual presence on the ASCO Community of Practice site. So, if you were interested in any one of these, and you can see them on the ASCO Communities of Practice sites, you would ask to become a member. Once granted membership, then there is a whole webpage of postings and conversations that people can have. You can get email digests of conversations that happen on the website, and then you can anchor it with in-person participation at the Annual Meeting. Dr Monty Pal: That is awesome, and I can think of so many different foci within oncology that really sort of deserve a Community of Practice. This definitely being one of them. You know, it strikes me as being so interesting. I mean, the checkpoint inhibitors have been around for a while now. I think when you and I were in training, gosh, back then, these were just a little bit of a pipe dream, right? But having said that, I would probably say that more than half of my kidney cancer practice is either on checkpoint inhibitors, and the vast majority have been on one at some point in their past, right? With that in mind, you know, we have all treated a lot of patients with these drugs. Why is it that we still struggle to manage the toxicities? And just to take that one step further, what are some of the toxicities that, perhaps through ASPIRE or through your experience, people struggle with the most? Dr Pauline Funchain: So, I think we are still struggling with these because again, they are new disease states, right? This is what we all experienced with COVID, a brand-new virus and a brand-new syndrome. We now have 20-plus of these as irAEs. And what we have realized about them is the immune activation that happens with these is so much more than what we have seen with autoimmune diseases. So for instance, if you have a Crohn's or ulcerative colitis, you will top out at 40 to 60 milligrams of prednisone if a Crohn's flare or ulcerative colitis flare happens. But for our severe IR colitises, you know, it is at least 1 mg per kg, often goes up to 2 mg per kg. We, in some cases, have done 1 gram pulses if we are worried that somebody is going to perforate. So that was sort of like the first 5 years of treating irAE, and then now in the sort of second 5 years of treating irAE, we have realized that that is a lot of immunosuppression, and we might be able to get away with less with the newer biologics that are on board. So, we are struggling to try to get the data for some of these irAEs that we knew, we have known for a while, but to try to get newer treatments that may immunosuppress less so that you may still be able to retain that tumor response. And in fact, some of the preclinical studies suggest that some of these biologics may actually synergize with the immunotherapy and actually make the immunotherapy more effective from a tumor perspective and calm down the irAE as sort of the bystander effect. So we are still trying to optimize those. Getting up trials in the space has been very difficult. That is one of the reasons for the genesis of ASPIRE because we realized we needed to band together to have a bigger voice in that realm. Then there are other things that are brand new. So we talked about Triple-M. So Triple-M, again, with Triple-M or any myocarditis or myasthenia, I mean, there is about a 50% chance of death from irAE based on the literature. I think we are getting better at recognizing this, and so at Stanford we have some data to say that if you serially follow troponin, that maybe your outcomes are better. You can potentially lower the percentage of cases that are fatal because you can catch them early. I mean, this is all preliminary data, but again, these are all things that are evolving, and we do not all have the right answer. I mean, even the serial troponin thing, I think, is pretty controversial. And in fact, at one of our quarterly Zoom meetings that we are doing in ASPIRE in December is going to sort of flush out that controversy about serial troponin measuring and what is the best thing to use? Would you use something like abatacept or would you use ruxolitinib? Which one is better? I think there is a lot of controversy still about these things. Dr Monty Pal: You have really piqued my curiosity here because you think about the cons of treating irAEs, right? And I worry exactly about what you had mentioned, right, which is, "Gosh, what is going on with this tumor in terms of immunosuppression?" But you think about some of the newer agents, you mentioned ruxolitinib, I have heard of dasatinib, for instance, in this setting. Frankly speaking, a lot of these, as you point out, are really thought of as being also anticancer drugs. So you have really got me thinking about the potential synergy between perhaps suppressing an irAE and augmenting antitumor activity, which I think is very interesting. Am I on the right track with that? Dr Pauline Funchain: I think so, but you will find that a lot of people will not even go there because they are worried about how much immunosuppression you are going to cause. I am at heart a geneticist, but I think an immunologist will happily tell you that the immune system is very complex. There are multiple pathways, and these drugs do not all target the same immune pathways. So if we understand a little bit more about the pathways we are targeting and pick apart the pathways that are really, really tumor relevant and the other pathways that are not tumor relevant, you may be able to piece together a better marriage of tumor response and irAE control. Dr Monty Pal: Kind of on this topic, and again, leaning on your background in genetics, where are we in terms of predicting these irAEs? I mean, you would think the holy grail would be picking out a snip or something of this for it, right, that could potentially identify that patient who is going to get Triple-M or, you know, at the very least a significant high-grade irAE event. Are we anywhere closer to that in 2025? Dr Pauline Funchain: There have been data published. There have been some big GWAS studies. All of the effect sizes are pretty small. So there are some prediction algorithms, but none of them are clinically useful. And I think when you look at the odds ratios, they will increase risk by maybe 20%. I think one of the things that we found in a very small series and supported anecdotally is something as easy as family history of autoimmune disease is probably more predictive at this point than any of those types of markers. I think we will get there, but we are not anywhere near where we would like to be. Things like TMB also, actually, there is some good data about higher TMB, higher risk of irAE too. Dr Monty Pal: Interesting. I see all this data coming through, IL-8 polymorphisms, etc. And I just wondered if any of that was ready for prime time. But I mean, this is a good message for the practicing clinician. Sounds like we are not quite there yet. And I could probably keep you on for another entire podcast to talk about this topic, but let us see if we can at least skim the surface. I never thought I would see the day when BiTEs and CAR-Ts were entering into my kidney cancer practice, but in fact, it is really become central to a lot of our clinical trials in RCC these days. I would be lying if I did not say that I was not struggling with the toxicities and so forth associated with these drugs. Can you give us a quick primer, maybe just good resources that people can go to for managing toxicity with BiTEs and with CAR and with some of these novel therapeutic modalities that we are using in the oncology clinics? Dr Pauline Funchain: I know there is a recently published toxicity manual for BiTEs in hematologic malignancies, I think it was in Blood. CAR-T is covered in many irAE guidelines. So ASCO guidelines actually has a CAR-T [cell therapy guideline], and I would be remiss not to point out that actually ASCO has a, I am a little biased, but a wonderful guideline on irAE that is actually being updated as we speak. We are hoping for publication next year. I find the format of that, there are many guidelines out there, actually. There is ASCO, SITC, ESMO has a guideline for irAE, but I find the formatting of the ASCO guideline to be much easier to flip through during clinic, just because of the visual format of the tables. But that is going to be updated next year. And with CAR-T, there is now multiple publications also in terms of guidelines. But what I will say about bispecifics and CAR-T, so they have very similar toxicities in terms of the cytokine release and also with the ICANS, so the neurotoxicity. But what we have been finding that is really interesting with BiTEs and CAR-T, and actually even with TIL, cytokine release is very similar to some of the IL-2 toxicities but not identical that we see with TIL treatment. But now we are starting to see overlap. So patients who have been treated with immunotherapy and then go on to get a bispecific or then go on to get TIL, so I have seen some colitises that have occurred after the fact. Some of the newer CAR-Ts without checkpoint have been causing some really interesting, probably not in a good way, but interesting biologically, colitises that are really refractory. So we are starting to see some overlap, and again, I think this field is just evolving constantly. Dr Monty Pal: Yeah, no, I almost think I need to go back to that fellowship that you and I did together 20 years ago and, you know, and see if I could repeat some coursework on CAR-T management. You know, Pauline, I could probably keep you on the horn for hours, but this has just been terrific. Thank you so much for sharing all of your insights with us today on the ASCO Daily News Podcast. Dr Pauline Funchain: Thank you for the invitation. It was wonderful to talk about this, and it was wonderful to catch up a little bit, Monty. Dr Monty Pal: Same here, same here. And thanks to our listeners too. If you value the insights you heard today on the ASCO Daily News Podcast, please rate, review, and subscribe wherever you get your podcasts. Disclaimer: The purpose of this podcast is to educate and to inform. This is not a substitute for professional medical care and is not intended for use in the diagnosis or treatment of individual conditions. Guests on this podcast express their own opinions, experience, and conclusions. Guest statements on the podcast do not express the opinions of ASCO. The mention of any product, service, organization, activity, or therapy should not be construed as an ASCO endorsement. Find out more about today's speakers: Dr. Monty Pal @montypal Dr. Pauline Funchain @FunchainMD Follow ASCO on social media: @ASCO on Twitter ASCO on Bluesky ASCO on Facebook ASCO on LinkedIn Disclosures: Dr. Monty Pal: Speakers' Bureau: MJH Life Sciences, IntrisiQ, Peerview Research Funding (Inst.): Exelixis, Merck, Osel, Genentech, Crispr Therapeutics, Adicet Bio, ArsenalBio, Xencor, Miyarsian Pharmaceutical Travel, Accommodations, Expenses: Crispr Therapeutics, Ipsen, Exelixis Dr. Pauline Funchain: Consulting or Advisory Role: Merck, Replimune, Sanofi/Regeneron, Immunocore, Tempus Research Funding (Inst.): Pfizer, Bristol-Myers Squibb, IDEAYA Biosciences, Linnaeus Therapeutics Travel, Accommodations, Expenses: Merck
It's official: The Kyler Murray era is on hold. On today's episode of The Valley Verdict, we break down the day-by-day drama that led to the Cardinals placing Kyler Murray on Injured Reserve and handing the starting job to Jacoby Brissett for the rest of the season.We trace the dramatic shift through the coach's own words:The Defining Moment: We analyze Jonathan Gannon's explosive comments to Burns and Gambo on 98.7 FM, where he confirmed that even if Kyler were healthy, he would have stuck with Jacoby, stating: "I like where we're at right now with the offense moving forward."The Unveiling: We dissect Gannon's media availability on Wednesday, where he confirmed the news that Kyler has been moved to IR, making the QB decision for the remainder of the season official.Jacoby's Approach: We hear from Jacoby Brissett on his mindset and approach now that he is the undisputed starter for the rest of the year.The Franchise Fallout: We dive into the conversations on Bickley and Marotta and Burns and Gambo, discussing the biggest question now facing the franchise: Have we truly seen the last of Kyler Murray in a Cardinals uniform?Don't miss our full analysis of what this decision means for the future of the Cardinals organization! Subscribe to The Valley Verdict and follow us on Facebook [@thevalleyverdict], Instagram [@thevalleyverdictpodcast], and YouTube [@thevalleyverdict] for more analysis.
12th Man Roundtable with HUGH MILLEN & GREGG BELL (Tacoma News Tribune) We have a trade to talk about! Why did the Hawks trade for Shaheed and what does he bring to this offense that's already having success? :30- The Seahawks host the Cardinals on Sunday and the biggest story is what's going on with Kyler Murray? Jacoby Brissett was named the starter for Arizona and Murray was sent to IR. What's really going on and are the Cardinals a better team without Murray? :45- We wrap up the Roundtable with Bucky's prediction, Gregg's key to the game and one last thing from Hugh Millen. See omnystudio.com/listener for privacy information.
- Lumberbuck is back! Have we been underestimating the Seahawks? Usually we are guilty of thinking our teams are better than the National folks give them credit for, but this time, we might need to be the ones to catch up. National talking heads are saying things like the Seahawks are at the front of the line as far as SB teams, and how will anyone defend them now? NFL has them #1 in their power rankings this week! We were positive this team would be better than the preseason talk and rankings had them listed, but even we couldn't predict this. :30- Jorge Polanco declined his option with the Mariners and will test free agency, but the Mariners could still bring him back if the price is right. Murakami is the latest Japanese sensation to head to the US and the Mariners are being mentioned in every conversation regarding the corner infielder, what would it cost? :45- Kyler Murray has been sent to IR, but how did it come to this? From supposedly getting ready to start on MNF, to the IR in just days, is it really the injury or was Arizona just done with the former first-round pick? See omnystudio.com/listener for privacy information.
Valsts drošība ir šobrīd galvenā prioritāte Latvijā. Krustpunktā izvaicājam aizsardzības ministru Andri Sprūdu (Progresīvie). Jautājumus kopā ar raidījuma vadītāju uzdod TV24 žurnālists Romāns Meļņiks un Latvijas Radio Pētnieciskās žurnālistikas daļas žurnālists Kārlis Arājs. Pēdējo dienu kaislības ap Saeimas lēmumiem bijušas tik skaļas, ka ir arī bijis pamats domāt par valdības krīzi. Liekas, ka vien nākamā gada budžeta pieņemšana kavē politiķus rīkoties radikālāk. Tas tāpēc, ka saspringta situācija nav tikai Latvijas iekšpolitikā, visas Eiropas drošības jomā ir pamatīgi izaicinājumi. Ir jāpieņem budžets, kurā īpaša prioritāte ir atvēlēta aizsardzības jomai. Par krīzēm, par izaicinājumiem, to, kā sevi sargāsim, saruna Krustpunktā ar Andri Sprūdu.
Ir noslēdzies protesta mītiņš pret Latvijas izstāšanos no Stambulas konvencijas. Krustpunktā diskutējam par izskanējušo. Sazināmies ar politisko partiju pārtāvjiem. Studijā diskutē domnīcas "Providus" direktore Sanda Liepiņa un politologs Andis Kudors. Viedokli izsaka Armands Krauze no Zaļo un zemnieku savienības, Edgars Tavars no Apvienotā saraksta, Edmunds Jurēvics no Jaunās Vienotības.
Naujausiame Pemzos epizode šįkart turime makabrišką meilės istoriją, kurios epicentre – vokietis radiologas Carlas Tanzleris ir sapnuose jam į žmonas pažadėta moteris, kurios rolę atliko Amerikos kubietė Elena de Hoyos. Deja, Elena greitai mirė, tačiau Karlo meilė jai tik dar labiau sustiprėjo. Lengvai besitrinanti linija tarp genialumo ir beprotybės, tamsias paslaptis savy saugojęs besparnis lėktuvas, daug muilo, ir dar daugiau formalino. Istorijos įvykiai tik užduosiantys dar daugiau klausimų. Kokios yra gedėjimo ribos? Ar Carlo sukurti įrankiai gali nubraukti jo groteskiškus darbelius? Ir prie ko čia karšta jautienos arbata? Sužinosite įsijungę epizodą! Diskusijas sukėlęs Carlo lėktuvas: https://imgur.com/a/T04SfKx Iliustracija: @tinymischiefs. Muzika: Abydos_Music, DELOSound, Gregor Quendel, HitsLab, lorenzobuczek, Lydia Mendoza, TheFealdoProject.
The Cardinals stunned the Cowboys with Jacoby Brissett under center. Kyler is on the IR. What does this mean for the Seahawks game and the rest of the season? Hosted by Simplecast, an AdsWizz company. See pcm.adswizz.com for information about our collection and use of personal data for advertising.
No podcast ‘Notícia No Seu Tempo’, confira em áudio as principais notícias da edição impressa do jornal ‘O Estado de S.Paulo’ desta quinta-feira (06/11/2025): A operação que deixou 121 mortos em morros do Rio, o governo de Cláudio Castro (PL) recebeu carta da gestão Donald Trump em que o governo dos EUA lamenta a morte de quatro policiais e se coloca “à disposição para qualquer apoio necessário”. O líder do PT na Câmara, Lindbergh Farias (RJ), pediu ao STF abertura de inquérito para apurar a conduta do governador fluminense. O petista acusa Castro de crime de traição e atentado à soberania nacional. De acordo com o deputado, o governador encaminhou à Embaixada dos EUA documentos sobre a atuação do Comando Vermelho e pede que a facção seja classificada como organização terrorista. E mais: Metrópole: Cúpula de Belém começa sob desafios e sem líderes claros Economia: Senado aprova isenção de IR até R$ 5 mil e taxação maior de alta renda Internacional: Lula vai à cúpula da Celac em solidariedade à Venezuela Cultura: Intensidade e fragilidade de Chorão ganham as telasSee omnystudio.com/listener for privacy information.
Cúpula dos Líderes antes da COP 30 começa hoje. Senado aprova isenção do IR para quem ganha até R$ 5 mil. Câmara aprova projeto que pode dificultar aborto legal em crianças vítimas de estupro. Black Friday: madrugada é horário preferido dos golpistas, diz Serasa. Alok, Eminem, Ozzy, Britney: veja quantos brasileiros têm nomes de estrelas da música.
Primer episodio del nuevo formato de psicofilia, qué nervios! Espero lo disfruten. Irá mejorando la producción, lo prometo.
Jau daudzus gadus redzam, cik ļoti informācijas tehnoloģijas un saziņas kanāli ietekmē informācijas apriti un iedzīvotāju noskaņojumu. Kā vairot sabiedrības noturību pret jauno tehnoloģiju radītajiem drošības riskiem? Par to diskusija Krustpunktā. Analizē Latvijas Universitātes rektors Gundars Bērziņš, mākslīgā intelekta attīstītājs un startup uzņēmējs Zigmārs Bērziņš, Vidzemes Augstskolas asociētā profesore un Latvijas Nacionālās aizsardzības akadēmijas vadošā pētniece Ieva Bērziņa un Rīgas Stradiņa universitātes RSU asociētā profesore Ilva Skulte. Pēdējo dienu notikumi ap Stambulas konvenciju ļoti spilgti izgaismo riskus, par kuriem esam runājuši jau iepriekš. Proti, ar mums var itin viegli manipulēt. Konvencija ir sašķēlusi sabiedrību divās pretējās nometnēs, abas puses viena otru vaino muļķībā, nespējā kritiski domāt. Ir argumenti, kas parādās publiskajā telpā, kuri reizēm liek saķert galvu. Ir skaidrs, ka mūsu spēja pašiem lasīt, izšķirt, pieņemt kādus atbildīgus lēmumus vismaz daļā sabiedrības ir ļoti vāja. Ja runa būtu tikai par konvenciju, varētu kaut kā vieglāk samierināties. Bet stāsts jau nav tikai par viena dokumenta lasīšanu. Tehnoloģijām attīstoties, mūsu spēja pamanīt apmānu nonāk arvien lielākā riska zonā. Notikumi citās valstīs rāda, ka tas var kļūt pat par nacionālās drošības jautājumu. Vai ir iespējams kaut ko darīt, lai paaugstinātu mūsu spēju pretoties apzinātiem nodomiem mūs apkrāpt, piemuļķot, varbūt pat pakļaut?
Rafael Mariano Grossi é o convidado do Podcast ONU News; desde 2022, ele tem servido como mediador entre Ucrânia e Rússia sobre a segurança da central nuclear de Zaporizhzhya, a maior da Europa, que já foi bombardeada no conflito entre os dois países; outra prioridade para o líder da Agência Internacional de Energia Atômica é o retorno das inspeções nucleares ao Irã, que deixou de cooperar com a agência; nesta entrevista, Grossi também fala de liderança feminina, combate ao câncer, ação climática, Copa do Mundo e planos de concorrer a líder máximo da organização.
In the final hour of The Chris Russell Show on The Team 980, Chris pulls in A-MAC to break down Jayden Daniels and the Commanders' regression, analyzing why the team has struggled this season. The conversation continues with takes on RGIII's irrelevance and the impact of old players and injuries on the team's performance. Chris and the audience also discuss Kyler Murray's "soft benching" as he gets placed on IR. The hour wraps with the always-entertaining Dumb Dumb of the Day, highlighting one of the week's wildest stories.
The Chris Russell Show kicks off with Chris voicing his disappointment over the Commanders' lack of moves before the trade deadline, while also taking a look at the NFC East's New York Giants, who similarly stood pat. Fans call in to share their frustration and weigh in on what they would have wanted the Commanders to do. The conversation then shifts to Kurt Warner's critique of Jayden Daniels' second-year performance, with Chris agreeing on Daniels' regression and breaking down what it means for Washington moving forward. Listeners join in, offering reactions and sparking debate on the quarterback's development. Chris and A-MAC continue analyzing the Commanders' struggles, examining the impact of injuries, veteran players, and past team decisions, while also touching on Kyler Murray's “soft benching” after being placed on IR. The show wraps with the Dumb Dumb of the Day, highlighting one of the week's most head-scratching stories.
Passando a Limpo: Nesta quarta-feira (5), Igor Maciel e a bancada do programa conversam com o Analista Político e Diretor Executivo do Livres, Magno Karl, sobre a CPI do Crime. A Gerente Geral de Planejamento e Desenvolvimento de Cargos e Carreiras, Heliane Lima, conversa sobre o Concurso Público Unificado de Pernambuco. O Advogado tributarista, Alexandre Albuquerque, repercute a votação do projeto de isenção do IR até R$ 5 mil. O programa também conta a participação do correspondente em Portugal, Antônio Martins.
Farnaz Ohadi nació en Irán, allí fue donde aprovechó cada oportunidad para acercarse a la música y descubrió su auténtica voz artística. Comenzó́ a estudiar piano a los cinco años, participó en coros y producciones escolares. Emigró a Canadá y allí formó su voz en la tradición occidental, en el ámbito operístico, pero también ahondó en la tradición persa. Fue cuando el flamenco se cruzó en su vida, y desde entonces lo incorpora a su música, buscando un elocuente cruce entre la potencia emocional de ese género y la sensibilidad de la poesía persa. Ohadi ha estado comprometida con dar voz a las mujeres iraníes, que aún enfrentan restricciones en las actuaciones públicas, al tiempo que explora en su obra temas de justicia social, empoderamiento femenino e historias personales.Escuchar audio
En un mundo interconectado donde las decisiones individuales y colectivas moldean el destino de naciones enteras, la falta de ética emerge como una sombra silenciosa pero devastadora. No se trata solo de escándalos mediáticos —corrupción en gobiernos, fraudes corporativos o violaciones en redes sociales—, sino de un deterioro profundo en los principios morales que guían nuestras acciones cotidianas. ¿Qué sucede cuando el "yo primero" suplanta al bien común? Banda sonora: Drop the Tapes - Biblioteca de audio de YouTube Donaciones local: https://iglesiadeciudadreal.es/donaciones Web: http://iglesiadeciudadreal.es/ Podcast: http://www.ivoox.com/podcast-iglesia-. YouTube: https://www.youtube.com/channel/UCPq8l9Q7KcX7j6iOGDPP_zg x (antes Twitter): https://x.com/home?lang=es Instagram: https://www.instagram.com/ Facebook: https://www.facebook.com/IglesiaCristianaEvangelicaDeCiudadReal Nota informativa: En todos nuestros videos se pueden traducir los SUBTÍTULOS a cualquier idioma. Ir a configuración y elegir idioma de subtitulo. 01/11/2025 - DÍA DE LA REFORMA PROTESTANTE La falta de ética, con sus ramificaciones en desigualdad, desconfianza y crisis existenciales, nos confronta con una verdad ineludible: sin un marco moral sólido, el progreso humano se convierte en un espejismo ilusorio. Hemos visto cómo sociedades enteras se desmoronan bajo el peso de la avaricia y la indiferencia, pero también cómo actos de integridad — valientes y movimientos ciudadanos— encienden la esperanza de cambio. En última instancia, combatir esta lacra exige no solo leyes más estrictas, sino un renacer ético en cada uno de nosotros: educar en valores, fomentar la empatía y priorizar la integridad sobre el beneficio inmediato. Solo así, reconociendo que la ética no es un lujo, sino el cimiento de la civilización, podremos forjar un futuro donde la humanidad prevalezca sobre el egoísmo.
El declive de la iglesia y del evangelio, aunque alarmante en sus cifras y consecuencias, no es el veredicto final sobre el plan divino, sino un llamado profético a la renovación. Donde la institución flaquea por complacencia o hipocresía, el evangelio puro —centrado en la cruz, la gracia y la misión— persiste como semilla de resurrección, recordándonos que la verdadera iglesia no se mide por números, sino por fidelidad. Banda sonora: Drop the Tapes - Biblioteca de audio de YouTube Donaciones local: https://iglesiadeciudadreal.es/donaciones Web: http://iglesiadeciudadreal.es/ Podcast: http://www.ivoox.com/podcast-iglesia-. YouTube: https://www.youtube.com/channel/UCPq8l9Q7KcX7j6iOGDPP_zg x (antes Twitter): https://x.com/home?lang=es Instagram: https://www.instagram.com/ Facebook: https://www.facebook.com/IglesiaCristianaEvangelicaDeCiudadReal Nota informativa: En todos nuestros videos se pueden traducir los SUBTÍTULOS a cualquier idioma. Ir a configuración y elegir idioma de subtitulo. 01/11/2025 - DÍA DE LA REFORMA PROTESTANTE Enfrentando un mundo hostil, los creyentes deben priorizar la oración ferviente, la evangelización audaz y la unidad en Cristo, transformando la crisis en catalizador para un avivamiento global. Al fin, como en tiempos pasados de apostasía, Dios soberano preserva un remanente fiel; el desafío es unirnos a él, no para lamentar el ayer, sino para proclamar un mañana donde el evangelio no decline, sino que conquiste corazones sedientos de verdad eterna.
Hire Yourself Podcast with Pete GilfillanWhen you look in the mirror, do you see someone truly happy? Someone in control of their life, time, and destiny?In this powerful episode, Pete Gilfillan shares a deeply personal story about his own mirror moment—the night he realized his high-paying corporate career was costing him everything that mattered. From endless travel to missing family milestones, Pete faced the truth: success on paper meant nothing without control, balance, and fulfillment. That realization pushed him to walk away from corporate life and build a business—and a life—on his own terms.Now, he helps other executives do the same through franchise ownership.In this episode, Pete discusses:1. The Mirror TestHow asking yourself hard questions about happiness, time, and control can reveal if you're truly fulfilled—or just surviving.2. The Wake-Up MomentPete's personal story of sitting in a hotel room, lost in the grind, and realizing he wasn't living the life he wanted.3. The Cost of Corporate SuccessThe hidden price executives pay in health, family time, and personal freedom when they chase the next promotion instead of purpose.4. The Power of OwnershipWhy entrepreneurship—especially through franchising—gives you control over your destiny, schedule, and income.5. Life on Your TermsHow franchise ownership can help you reclaim your time, your family, and your sense of purpose.Key Takeaways:Climbing the corporate ladder can come at the cost of your freedom and happiness.Real success starts when you take control of your time, wealth, and life direction.Your “mirror moment” can be the start of your transformation.Franchising offers a proven path to entrepreneurship—with structure and support.The best time to take back your life is now.“Your mirror doesn't lie. If you don't like what you see—it's time to change the reflection.” — Pete GilfillanCONNECT WITH PETE GILFILLAN:
Irónicamente para tener suerte toca actuar sin pensar.
The guys share their thoughts on the Jaguars passing game going forward as Travis Hunter is sent to IR and Brian Thomas Jr. looks set to miss some time. Whether it's the biggest stars in the league or new rookies bursting on the scene, you won't get better wideout information anywhere else. Along the way, they'll break down the biggest stories in the NFL and offer up a few big-picture fantasy football thoughts. Follow the guys on Twitter @JamesDKoh and @MattHarmon_BYB. Follow Reception Perception @RecepPerception. Download and Subscribe to the Reception Perception Show anywhere you get your podcasts. Watch segments of the show on YouTube at Matt Harmon!! To learn more about listener data and our privacy practices visit: https://www.audacyinc.com/privacy-policy Learn more about your ad choices. Visit https://podcastchoices.com/adchoices
LaVar Arrington & TJ Houshmandzadeh talk about former LSU head coach Brian Kelly's firing, the expectations at LSU, and more! Plus, the Dolphins fire their GM but not their head coach, Travis Hunter heads to IR, and more! #2pros #fsrweekendsSee omnystudio.com/listener for privacy information.